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Valentina Factor

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Jens U Marquardt; Daekwan Seo; Koichi Uchida; Elizabeth A Conner; Valentina M Factor; Matthew C Gillen; Luis E Gómez-Quiroz; Pal Kaposi-Novak; Mitsuteru Kitade; Snorri S Thorgeirsson
Loss of c-Met accelerates development of liver fibrosis in response to CCl(4) exposure through deregulation of multiple molecular pathways.
Seung Bum Lee; Jens U Marquardt; Kye-Yoon Park; Daekwan Seo; Dongho Choi; Elizabeth A Conner; Valentina M Factor; Agnes Holczbauer; Snorri S Thorgeirsson
Contribution of hepatic lineage stage-specific donor memory to the differential potential of induced mouse pluripotent stem cells.
Jesper B andersen; Itzhak Avital; Andrew Barbour; Boris R Blechacz; Elizabeth A Conner; Valentina M Factor; Matthew C Gillen; Mina Komuta; Lewis R Roberts; Tania Roskams; Bart Spee; Snorri S Thorgeirsson
Genomic and genetic characterization of cholangiocarcinoma identifies therapeutic targets for tyrosine kinase inhibitors.

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2012: Jens U Marquardt; Daekwan Seo; Koichi Uchida; Elizabeth A Conner; Valentina M Factor; Matthew C Gillen; Luis E Gómez-Quiroz; Pal Kaposi-Novak; Mitsuteru Kitade; Snorri S Thorgeirsson
Loss of c-Met accelerates development of liver fibrosis in response to CCl(4) exposure through deregulation of multiple molecular pathways.
Biochimica et biophysica acta 2012;1822(6):942-51.
2012: Seung Bum Lee; Jens U Marquardt; Kye-Yoon Park; Daekwan Seo; Dongho Choi; Elizabeth A Conner; Valentina M Factor; Agnes Holczbauer; Snorri S Thorgeirsson
Contribution of hepatic lineage stage-specific donor memory to the differential potential of induced mouse pluripotent stem cells.
Stem cells (Dayton, Ohio) 2012;30(5):997-1007.
2012: Jesper B andersen; Itzhak Avital; Andrew Barbour; Boris R Blechacz; Elizabeth A Conner; Valentina M Factor; Matthew C Gillen; Mina Komuta; Lewis R Roberts; Tania Roskams; Bart Spee; Snorri S Thorgeirsson
Genomic and genetic characterization of cholangiocarcinoma identifies therapeutic targets for tyrosine kinase inhibitors.
Gastroenterology 2012;142(4):1021-1031.e15.
2012: Tsuyoshi Ishikawa; Mitsuteru Kitade; Jens U Marquardt; Chiara Raggi; Daekwan Seo; Elizabeth A Conner; Valentina M Factor; Snorri S Thorgeirsson
Hepatocyte growth factor/c-met signaling is required for stem-cell-mediated liver regeneration in mice.
Hepatology (Baltimore, Md.) 2012;55(4):1215-26.
2011: Y-H Lee; Ian MacLachlan; J U Marquardt; C Raggi; D Seo; Jesper B andersen; I Avital; E A Conner; Valentina M Factor; L E Gómez-Quiroz; T Ishikawa; A D Judge; B-K Kim; M Kitade; Snorri S Thorgeirsson
Molecular targeting of CSN5 in human hepatocellular carcinoma: a mechanism of therapeutic response.
Oncogene 2011;30(40):4175-84.
2011: Cedric Coulouarn; Valentina M Factor; Elizabeth A Conner; Snorri S Thorgeirsson
Genomic modeling of tumor onset and progression in a mouse model of aggressive human liver cancer.
Carcinogenesis 2011;32(10):1434-40.
2011: Diego F Calvisi; Sara Ladu; Elizabeth A Conner; Daekwan Seo; Jer-Tsong Hsieh; Valentina M Factor; Snorri S Thorgeirsson
Inactivation of Ras GTPase-activating proteins promotes unrestrained activity of wild-type Ras in human liver cancer.
Journal of hepatology 2011;54(2):311-9.
2010: Yun-Han Lee; Jesper B andersen; Ho-Taek Song; Adam D Judge; Daekwan Seo; Tsuyoshi Ishikawa; Jens U Marquardt; Mitsuteru Kitade; Marian E Durkin; Chiara Raggi; hyun goo woo; Elizabeth A Conner; Itzhak Avital; Ian Maclachlan; Valentina M Factor; Snorri S Thorgeirsson
Definition of ubiquitination modulator COP1 as a novel therapeutic target in human hepatocellular carcinoma.
Cancer research 2010;70(21):8264-9.
2010: Jesper B andersen; Valentina M Factor; Jens U Marquardt; Chiara Raggi; Yun-Han Lee; Daekwan Seo; Elizabeth A Conner; Snorri S Thorgeirsson
An integrated genomic and epigenomic approach predicts therapeutic response to zebularine in human liver cancer.
Science translational medicine 2010;2(54):54ra77.
2010: J U Marquardt; Valentina M Factor; Snorri S Thorgeirsson
Epigenetic regulation of cancer stem cells in liver cancer: current concepts and clinical implications.
Journal of hepatology 2010;53(3):568-77.
2010: Jesper B andersen; Roberto Loi; Andrea Perra; Valentina M Factor; Giovanna M Ledda-Columbano; amedeo columbano; Snorri S Thorgeirsson
Progenitor-derived hepatocellular carcinoma model in the rat.
Hepatology (Baltimore, Md.) 2010;51(4):1401-9.
2010: Valentina M Factor; Daekwan Seo; Tsuyoshi Ishikawa; Pal Kaposi-Novak; Jens U Marquardt; Jesper B andersen; Elizabeth A Conner; Snorri S Thorgeirsson
Loss of c-Met disrupts gene expression program required for G2/M progression during liver regeneration in mice.
PloS one 2010;5(9):.
2009: Cedric Coulouarn; Valentina M Factor; Jesper B andersen; Marian E Durkin; Snorri S Thorgeirsson
Loss of miR-122 expression in liver cancer correlates with suppression of the hepatic phenotype and gain of metastatic properties.
Oncogene 2009;28(40):3526-36.
2009: Drazen Zimonjic; Veronika Ullmannova-Benson; Valentina M Factor; Snorri S Thorgeirsson; Nicholas C Popescu
Recurrent and nonrandom DNA copy number and chromosome alterations in Myc transgenic mouse model for hepatocellular carcinogenesis: implications for human disease.
Cancer genetics and cytogenetics 2009;191(1):17-26.
2009: Pal Kaposi-Novak; Louis Libbrecht; hyun goo woo; Yun-Han Lee; Nathaniel C Sears; Cedric Coulouarn; Elizabeth A Conner; Valentina M Factor; Tania Roskams; Snorri S Thorgeirsson
Central role of c-Myc during malignant conversion in human hepatocarcinogenesis.
Cancer research 2009;69(7):2775-82.
2008: Sara Ladu; Diego F Calvisi; Elizabeth A Conner; Miriam Farina; Valentina M Factor; Snorri S Thorgeirsson
E2F1 inhibits c-Myc-driven apoptosis via PIK3CA/Akt/mTOR and COX-2 in a mouse model of human liver cancer.
Gastroenterology 2008;135(4):1322-32.
2008: Cedric Coulouarn; Valentina M Factor; Snorri S Thorgeirsson
Transforming growth factor-beta gene expression signature in mouse hepatocytes predicts clinical outcome in human cancer.
Hepatology (Baltimore, Md.) 2008;47(6):2059-67.
2008: Luis E Gómez-Quiroz; Valentina M Factor; Pal Kaposi-Novak; Cedric Coulouarn; Elizabeth A Conner; Snorri S Thorgeirsson
Hepatocyte-specific c-Met deletion disrupts redox homeostasis and sensitizes to Fas-mediated apoptosis.
The Journal of biological chemistry 2008;283(21):14581-9.
2008: Gaelle del Castillo; Valentina M Factor; Margarita Fernández; Alberto Alvarez-Barrientos; Isabel Fabregat; Snorri S Thorgeirsson; Aránzazu Sánchez
Deletion of the Met tyrosine kinase in liver progenitor oval cells increases sensitivity to apoptosis in vitro.
The American journal of pathology 2008;172(5):1238-47.
2007: Taro Takami; Pal Kaposi-Novak; Koichi Uchida; Luis E Gomez-Quiroz; Elizabeth A Conner; Valentina M Factor; Snorri S Thorgeirsson
Loss of hepatocyte growth factor/c-Met signaling pathway accelerates early stages of N-nitrosodiethylamine induced hepatocarcinogenesis.
Cancer research 2007;67(20):9844-51.
2007: Diego F Calvisi; Sara Ladu; Alexis Gorden; Miriam Farina; Ju Seog Lee; Elizabeth A Conner; Insa S Schroeder; Valentina M Factor; Snorri S Thorgeirsson
Mechanistic and prognostic significance of aberrant methylation in the molecular pathogenesis of human hepatocellular carcinoma.
The Journal of clinical investigation 2007;117(9):2713-22.
2006: Jeonghoon Heo; Valentina M Factor; Tania Uren; Yasushi Takahama; Ju Seog Lee; Marian E Major; Stephen M Feinstone; Snorri S Thorgeirsson
Hepatic precursors derived from murine embryonic stem cells contribute to regeneration of injured liver.
Hepatology (Baltimore, Md.) 2006;44(6):1478-86.
2006: Cedric Coulouarn; Luis E Gomez-Quiroz; Ju Seog Lee; Pal Kaposi-Novak; Elizabeth A Conner; Tatyana A Goldina; Galina E Onishchenko; Valentina M Factor; Snorri S Thorgeirsson
Oncogene-specific gene expression signatures at preneoplastic stage in mice define distinct mechanisms of hepatocarcinogenesis.
Hepatology (Baltimore, Md.) 2006;44(4):1003-11.
2006: Pal Kaposi-Novak; Ju Seog Lee; Luis Gòmez-Quiroz; Cedric Coulouarn; Valentina M Factor; Snorri S Thorgeirsson
Met-regulated expression signature defines a subset of human hepatocellular carcinomas with poor prognosis and aggressive phenotype.
The Journal of clinical investigation 2006;116(6):1582-95.
2006: Diego F Calvisi; Sara Ladu; Alexis Gorden; Miriam Farina; Elizabeth A Conner; Ju Seog Lee; Valentina M Factor; Snorri S Thorgeirsson
Ubiquitous activation of Ras and Jak/Stat pathways in human HCC.
Gastroenterology 2006;130(4):1117-28.
2005: Sergey V Novoselov; Diego F Calvisi; Vyacheslav Labunskyy; Valentina M Factor; Bradley A Carlson; Dmitri E Fomenko; Mohamed E Moustafa; Dolph L Hatfield; Vadim N Gladyshev
Selenoprotein deficiency and high levels of selenium compounds can effectively inhibit hepatocarcinogenesis in transgenic mice.
Oncogene 2005;24(54):8003-11.
2005: Lakita G Cavin; Fang Wang; Valentina M Factor; Swayamjot Kaur; Manickam Venkatraman; Snorri S Thorgeirsson; Marcello Arsura
Transforming growth factor-alpha inhibits the intrinsic pathway of c-Myc-induced apoptosis through activation of nuclear factor-kappaB in murine hepatocellular carcinomas.
Molecular cancer research : MCR 2005;3(7):403-12.
2005: Diego F Calvisi; Elizabeth A Conner; Sara Ladu; Eric R Lemmer; Valentina M Factor; Snorri S Thorgeirsson
Activation of the canonical Wnt/beta-catenin pathway confers growth advantages in c-Myc/E2F1 transgenic mouse model of liver cancer.
Journal of hepatology 2005;42(6):842-9.
2005: Daniel J Schoeffner; Shannon L Matheny; Takemi Akahane; Valentina M Factor; Adam Berry; Glenn Merlino; Unnur P Thorgeirsson
VEGF contributes to mammary tumor growth in transgenic mice through paracrine and autocrine mechanisms.
Laboratory investigation; a journal of technical methods and pathology 2005;85(5):608-23.
2004: Diego F Calvisi; Sara Ladu; Koji Hironaka; Valentina M Factor; Snorri S Thorgeirsson
Vitamin E down-modulates iNOS and NADPH oxidase in c-Myc/TGF-alpha transgenic mouse model of liver cancer.
Journal of hepatology 2004;41(5):815-22.
2004: Shoshiro Oe; Eric R Lemmer; Elizabeth A Conner; Valentina M Factor; Per Levéen; Jonas Larsson; Stefan Karlsson; Snorri S Thorgeirsson
Intact signaling by transforming growth factor beta is not required for termination of liver regeneration in mice.
Hepatology (Baltimore, Md.) 2004;40(5):1098-105.
2004: Lakita G Cavin; Manickam Venkatraman; Valentina M Factor; Swayamjot Kaur; Insa S Schroeder; Frank Mercurio; Amer A Beg; Snorri S Thorgeirsson; Marcello Arsura
Regulation of alpha-fetoprotein by nuclear factor-kappaB protects hepatocytes from tumor necrosis factor-alpha cytotoxicity during fetal liver development and hepatic oncogenesis.
Cancer research 2004;64(19):7030-8.
2004: Aránzazu Sánchez; Valentina M Factor; Luis A Espinoza; Insa S Schroeder; Snorri S Thorgeirsson
In vitro differentiation of rat liver derived stem cells results in sensitization to TNFalpha-mediated apoptosis.
Hepatology (Baltimore, Md.) 2004;40(3):590-9.
2004: Diego F Calvisi; Sara Ladu; Elizabeth A Conner; Valentina M Factor; Snorri S Thorgeirsson
Disregulation of E-cadherin in transgenic mouse models of liver cancer.
Laboratory investigation; a journal of technical methods and pathology 2004;84(9):1137-47.
2004: Diego F Calvisi; Sara Ladu; Valentina M Factor; Snorri S Thorgeirsson
Activation of beta-catenin provides proliferative and invasive advantages in c-myc/TGF-alpha hepatocarcinogenesis promoted by phenobarbital.
Carcinogenesis 2004;25(6):901-8.
2004: Diego F Calvisi; Valentina M Factor; Sara Ladu; Elizabeth A Conner; Snorri S Thorgeirsson
Disruption of beta-catenin pathway or genomic instability define two distinct categories of liver cancer in transgenic mice.
Gastroenterology 2004;126(5):1374-86.
2004: Chang-Goo Huh; Valentina M Factor; Aránzazu Sánchez; Koichi Uchida; Elizabeth A Conner; Snorri S Thorgeirsson
Hepatocyte growth factor/c-met signaling pathway is required for efficient liver regeneration and repair.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(13):4477-82.
2004: Aránzazu Sánchez; Valentina M Factor; Insa S Schroeder; Péter Nagy; Snorri S Thorgeirsson
Activation of NF-kappaB and STAT3 in rat oval cells during 2-acetylaminofluorene/partial hepatectomy-induced liver regeneration.
Hepatology (Baltimore, Md.) 2004;39(2):376-85.
2003: Lakita G Cavin; Raphaëlle Romieu-Mourez; Ganesh R Panta; Jiyuan Sun; Valentina M Factor; Snorri S Thorgeirsson; Gail E Sonenshein; Marcello Arsura
Inhibition of CK2 activity by TGF-beta1 promotes IkappaB-alpha protein stabilization and apoptosis of immortalized hepatocytes.
Hepatology (Baltimore, Md.) 2003;38(6):1540-51.
2003: Koji Hironaka; Valentina M Factor; Diego F Calvisi; Elizabeth A Conner; Snorri S Thorgeirsson
Dysregulation of DNA repair pathways in a transforming growth factor alpha/c-myc transgenic mouse model of accelerated hepatocarcinogenesis.
Laboratory investigation; a journal of technical methods and pathology 2003;83(5):643-54.
2003: Michael Rugaard Jensen; Valentina M Factor; A Fantozzi; Kristian Helin; Chang-Goo Huh; Snorri S Thorgeirsson
Reduced hepatic tumor incidence in cyclin G1-deficient mice.
Hepatology (Baltimore, Md.) 2003;37(4):862-70.
2003: Elizabeth A Conner; Eric R Lemmer; Aránzazu Sánchez; Valentina M Factor; Snorri S Thorgeirsson
E2F1 blocks and c-Myc accelerates hepatic ploidy in transgenic mouse models.
Biochemical and biophysical research communications 2003;302(1):114-20.
2003: Marcello Arsura; Ganesh R Panta; Jennifer D Bilyeu; Lakita G Cavin; Mika A Sovak; Aundrea A Oliver; Valentina M Factor; Rainer Heuchel; Frank Mercurio; Snorri S Thorgeirsson; Gail E Sonenshein
Transient activation of NF-kappaB through a TAK1/IKK kinase pathway by TGF-beta1 inhibits AP-1/SMAD signaling and apoptosis: implications in liver tumor formation.
Oncogene 2003;22(3):412-25.
2001: YH Im; Heung Tae Kim; Isaac Yi Kim; Valentina M Factor; Ki-Baik Hahm; Mario A Anzano; Ja-June Jang; Kathleen C Flanders; Diana C Haines; Snorri S Thorgeirsson; A Sizeland; Seong-Jin Kim
Heterozygous mice for the transforming growth factor-beta type II receptor gene have increased susceptibility to hepatocellular carcinogenesis.
Cancer research 2001;61(18):6665-8.
2001: Valentina M Factor; A L Oliver; Ganesh R Panta; Snorri S Thorgeirsson; Gail E Sonenshein; Marcello Arsura
Roles of Akt/PKB and IKK complex in constitutive induction of NF-kappaB in hepatocellular carcinomas of transforming growth factor alpha/c-myc transgenic mice.
Hepatology (Baltimore, Md.) 2001;34(1):32-41.
2001: Diego F Calvisi; Valentina M Factor; R Loi; Snorri S Thorgeirsson
Activation of beta-catenin during hepatocarcinogenesis in transgenic mouse models: relationship to phenotype and tumor grade.
Cancer research 2001;61(5):2085-91.
2001: Qi-An Sun; F Zappacosta; Valentina M Factor; PJ Wirth; Dolph L Hatfield; Vadim N Gladyshev
Heterogeneity within animal thioredoxin reductases. Evidence for alternative first exon splicing.
The Journal of biological chemistry 2001;276(5):3106-14.
2001: Drazen Zimonjic; H Zhang; Z Shan; Valentina M Factor; Jeffrey M. Trent; Snorri S Thorgeirsson; Nicholas C Popescu
DNA amplification associated with double minutes originating from chromosome 19 in mouse hepatocellular carcinoma.
Cytogenetics and cell genetics 2001;93(1-2):114-6.
2000: Elizabeth A Conner; Eric R Lemmer; M Omori; PJ Wirth; Valentina M Factor; Snorri S Thorgeirsson
Dual functions of E2F-1 in a transgenic mouse model of liver carcinogenesis.
Oncogene 2000;19(44):5054-62.
2000: Michael Rugaard Jensen; T Audolfsson; Valentina M Factor; Snorri S Thorgeirsson
In vivo expression and genomic organization of the mouse cyclin I gene (Ccni).
Gene 2000;256(1-2):59-67.
2000: Snorri S Thorgeirsson; Valentina M Factor; Elizabeth G Snyderwine
Transgenic mouse models in carcinogenesis research and testing.
Toxicology letters 2000;112-113():553-5.
2000: Valentina M Factor; D Laskowska; Michael Rugaard Jensen; JT Woitach; Nicholas C Popescu; Snorri S Thorgeirsson
Vitamin E reduces chromosomal damage and inhibits hepatic tumor formation in a transgenic mouse model.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(5):2196-201.
1999: E Santoni-Rugiu; Michael Rugaard Jensen; Valentina M Factor; Snorri S Thorgeirsson
Acceleration of c-myc-induced hepatocarcinogenesis by Co-expression of transforming growth factor (TGF)-alpha in transgenic mice is associated with TGF-beta1 signaling disruption.
The American journal of pathology 1999;154(6):1693-700.
1999: K H Preisegger; Valentina M Factor; Andrea Fuchsbichler; Conny Stumptner; Helmut Denk; Snorri S Thorgeirsson
Atypical ductular proliferation and its inhibition by transforming growth factor beta1 in the 3,5-diethoxycarbonyl-1,4-dihydrocollidine mouse model for chronic alcoholic liver disease.
Laboratory investigation; a journal of technical methods and pathology 1999;79(2):103-9.
1998: Vadim N Gladyshev; Valentina M Factor; Franck Housseau; Dolph L Hatfield
Contrasting patterns of regulation of the antioxidant selenoproteins, thioredoxin reductase, and glutathione peroxidase, in cancer cells.
Biochemical and biophysical research communications 1998;251(2):488-93.
1998: Michael Rugaard Jensen; Valentina M Factor; Snorri S Thorgeirsson
Regulation of cyclin G1 during murine hepatic regeneration following Dipin-induced DNA damage.
Hepatology (Baltimore, Md.) 1998;28(2):537-46.
1998: Valentina M Factor; A Kiss; JT Woitach; PJ Wirth; Snorri S Thorgeirsson
Disruption of redox homeostasis in the transforming growth factor-alpha/c-myc transgenic mouse model of accelerated hepatocarcinogenesis.
The Journal of biological chemistry 1998;273(25):15846-53.
1998: Snorri S Thorgeirsson; T Teramoto; Valentina M Factor
Dysregulation of apoptosis in hepatocellular carcinoma.
Seminars in liver disease 1998;18(2):115-22.
1997: Valentina M Factor; Michael Rugaard Jensen; Snorri S Thorgeirsson
Coexpression of C-myc and transforming growth factor alfa in the liver promotes early replicative senescence and diminishes regenerative capacity after partial hepatectomy in transgenic mice.
Hepatology (Baltimore, Md.) 1997;26(6):1434-43.
1997: Michael Rugaard Jensen; Valentina M Factor; Drazen Zimonjic; M J Miller; CL Keck; Snorri S Thorgeirsson
Chromosome localization and structure of the murine cyclin G1 gene promoter sequence.
Genomics 1997;45(2):297-303.
1997: Valentina M Factor; C Y Kao; E Santoni-Rugiu; JT Woitach; Michael Rugaard Jensen; Snorri S Thorgeirsson
Constitutive expression of mature transforming growth factor beta1 in the liver accelerates hepatocarcinogenesis in transgenic mice.
Cancer research 1997;57(11):2089-95.
1996: E Santoni-Rugiu; Péter Nagy; Michael Rugaard Jensen; Valentina M Factor; Snorri S Thorgeirsson
Evolution of neoplastic development in the liver of transgenic mice co-expressing c-myc and transforming growth factor-alpha.
The American journal of pathology 1996;149(2):407-28.
1996: Erwin P Böttinger; Valentina M Factor; M L Tsang; J A Weatherbee; Jeffrey B Kopp; S W Qian; Lalage M Wakefield; Anita B Roberts; Snorri S Thorgeirsson; Michael B. Sporn
The recombinant proregion of transforming growth factor beta1 (latency-associated peptide) inhibits active transforming growth factor beta1 in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(12):5877-82.
1996: Jeffrey B Kopp; Valentina M Factor; Miklós Mózes; Péter Nagy; N Sanderson; Erwin P Böttinger; Paul Klotman; Snorri S Thorgeirsson
Transgenic mice with increased plasma levels of TGF-beta 1 develop progressive renal disease.
Laboratory investigation; a journal of technical methods and pathology 1996;74(6):991-1003.
1996: C Y Kao; Valentina M Factor; Snorri S Thorgeirsson
Reduced growth capacity of hepatocytes from c-myc and c-myc/TGF-alpha transgenic mice in primary culture.
Biochemical and biophysical research communications 1996;222(1):64-70.
1995: N Sanderson; Valentina M Factor; Péter Nagy; J Kopp; P Kondaiah; Lalage M Wakefield; Anita B Roberts; Michael B. Sporn; Snorri S Thorgeirsson
Hepatic expression of mature transforming growth factor beta 1 in transgenic mice results in multiple tissue lesions.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(7):2572-6.