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Jérôme Fagart

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Junaid A Khan; Marc Lombès; Hugues Loosfelt; Geri Meduri; Mouad Alami; Larbi Amazit; Jean-Daniel Brion; Nathalie Chabbert-Buffet; Jérôme Fagart; Michel Fay; abdallah hamze; Abdellatif Tikad; Marie-Edith Rafestin-Oblin
A new strategy for selective targeting of progesterone receptor with passive antagonists.
Pauline Gaignard; Natalia Niemir; Jean Philippe Puech; Emilie Azouguene; Jeanne Dussau; Jérôme Fagart; Catherine Caillaud
Characterization of seven novel mutations on the HEXB gene in French Sandhoff patients.
Frédéric Brioude; Laurent Combettes; Jérôme Fagart; Bruno Francou; Marc Lombès; Ronan Roussel; say viengchareun; Jacques Young; Jérôme BOULIGAND; Sylvie Brailly-Tabard; Anne Guiochon-Mantel
Two families with normosmic congenital hypogonadotropic hypogonadism and biallelic mutations in KISS1R (KISS1 receptor): clinical evaluation and molecular characterization of a novel mutation.

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All Publications

2013: Junaid A Khan; Marc Lombès; Hugues Loosfelt; Geri Meduri; Mouad Alami; Larbi Amazit; Jean-Daniel Brion; Nathalie Chabbert-Buffet; Jérôme Fagart; Michel Fay; abdallah hamze; Abdellatif Tikad; Marie-Edith Rafestin-Oblin
A new strategy for selective targeting of progesterone receptor with passive antagonists.
Molecular endocrinology (Baltimore, Md.) 2013;27(6):909-24.
2013: Pauline Gaignard; Natalia Niemir; Jean Philippe Puech; Emilie Azouguene; Jeanne Dussau; Jérôme Fagart; Catherine Caillaud
Characterization of seven novel mutations on the HEXB gene in French Sandhoff patients.
Gene 2013;512(2):521-6.
2013: Frédéric Brioude; Laurent Combettes; Jérôme Fagart; Bruno Francou; Marc Lombès; Ronan Roussel; say viengchareun; Jacques Young; Jérôme BOULIGAND; Sylvie Brailly-Tabard; Anne Guiochon-Mantel
Two families with normosmic congenital hypogonadotropic hypogonadism and biallelic mutations in KISS1R (KISS1 receptor): clinical evaluation and molecular characterization of a novel mutation.
PloS one 2013;8(1):e53896.
2012: Jessica Huyet; Grégory PINON; Marie-Edith Rafestin-Oblin; Michel Raymond Fay; Jérôme Fagart
Structural determinants of ligand binding to the mineralocorticoid receptor.
Molecular and cellular endocrinology 2012;350(2):187-95.
2011: Camille Taillé; Sabine Grootenboer-Mignot; Céline Boursier; Laurence Michel; Marie-Pierre Debray; Jérôme Fagart; Lorena Barrientos; Arnaud Mailleux; Natacha Cigna; Florence Tubach; Joëlle Marchal-Sommé; Paul Soler; Sylvie Chollet-Martin; Bruno Crestani
Identification of periplakin as a new target for autoreactivity in idiopathic pulmonary fibrosis.
American journal of respiratory and critical care medicine 2011;183(6):759-66.
2011: Fábio L Fernandes-Rosa; Edwige-Ludiwyne Hubert; Jérôme Fagart; Nicolas Tchitchek; Debora Gomes; Elodie Jouanno; Arndt Benecke; Marie-Edith Rafestin-Oblin; Xavier Jeunemaitre; Sonir R Antonini; Maria-Christina Zennaro
Mineralocorticoid receptor mutations differentially affect individual gene expression profiles in pseudohypoaldosteronism type 1.
The Journal of clinical endocrinology and metabolism 2011;96(3):E519-27.
2011: Bruno Francou; Anne Guiochon-Mantel; Pierre Lecomte; Geri Meduri; Séverine Trabado; Adela Voican; Larbi Amazit; Jérôme BOULIGAND; Sylvie Brailly-Tabard; Philippe Chanson; Jérôme Fagart; Jacques Young
Normosmic congenital hypogonadotropic hypogonadism due to TAC3/TACR3 mutations: characterization of neuroendocrine phenotypes and novel mutations.
PloS one 2011;6(10):e25614.
2010: Jérôme Fagart; Alexander Hillisch; Jessica Huyet; Lars Bärfacker; Michel Fay; Ulrich Pleiss; Elisabeth Pook; Stefan Schäfer; Marie-Edith Rafestin-Oblin; Peter Kolkhof
A new mode of mineralocorticoid receptor antagonism by a potent and selective nonsteroidal molecule.
The Journal of biological chemistry 2010;285(39):29932-40.
2009: Isabelle Petit-Topin; Nathalie Turque; Jérôme Fagart; Michel Fay; André Ulmann; Erin Gainer; Marie-Edith Rafestin-Oblin
Met909 plays a key role in the activation of the progesterone receptor and also in the high potency of 13-ethyl progestins.
Molecular pharmacology 2009;75(6):1317-24.
2007: Jessica Huyet; Grégory PINON; Michel R Fay; Jérôme Fagart; Marie-Edith Rafestin-Oblin
Structural basis of spirolactone recognition by the mineralocorticoid receptor.
Molecular pharmacology 2007;72(3):563-71.
2007: Armelle-Natsuo Takeda; Grégory PINON; Marcelle Bens; Jérôme Fagart; Marie-Edith Rafestin-Oblin; Alain Vandewalle
The synthetic androgen methyltrienolone (r1881) acts as a potent antagonist of the mineralocorticoid receptor.
Molecular pharmacology 2007;71(2):473-82.
2007: Lucie Pujo; Jérôme Fagart; Françoise Gary; Dimitris T Papadimitriou; Aurélie Claës; Xavier Jeunemaître; Maria-Christina Zennaro
Mineralocorticoid receptor mutations are the principal cause of renal type 1 pseudohypoaldosteronism.
Human mutation 2007;28(1):33-40.
2005: Jérôme Fagart; Jessica Huyet; Grégory PINON; Marina Rochel; Claudine MAYER; Marie-Edith Rafestin-Oblin
Crystal structure of a mutant mineralocorticoid receptor responsible for hypertension.
Nature structural & molecular biology 2005;12(6):554-5.
2005: Jérôme Fagart; Cendrine Seguin; Grégory PINON; Marie-Edith Rafestin-Oblin
The Met852 residue is a key organizer of the ligand-binding cavity of the human mineralocorticoid receptor.
Molecular pharmacology 2005;67(5):1714-22.
2005: Armin Sturm; Nicolas R Bury; L Dengreville; Jérôme Fagart; G Flouriot; Marie-Edith Rafestin-Oblin; Patrick Prunet
11-deoxycorticosterone is a potent agonist of the rainbow trout (Oncorhynchus mykiss) mineralocorticoid receptor.
Endocrinology 2005;146(1):47-55.
2004: Vanessa Mynard; Olivier Latchoumanin; Laurence Guignat; Jocelyne Devin-Leclerc; Xavier Bertagna; Benjamin Barré; Jérôme Fagart; Olivier Coqueret; Maria Grazia Catelli
Synergistic signaling by corticotropin-releasing hormone and leukemia inhibitory factor bridged by phosphorylated 3',5'-cyclic adenosine monophosphate response element binding protein at the Nur response element (NurRE)-signal transducers and activators of transcription (STAT) element of the proopiomelanocortin promoter.
Molecular endocrinology (Baltimore, Md.) 2004;18(12):2997-3010.
2004: Paola Sartorato; Françoise Cluzeaud; Jérôme Fagart; Say Viengchareun; Marc Lombès; Maria-Christina Zennaro
New naturally occurring missense mutations of the human mineralocorticoid receptor disclose important residues involved in dynamic interactions with deoxyribonucleic acid, intracellular trafficking, and ligand binding.
Molecular endocrinology (Baltimore, Md.) 2004;18(9):2151-65.
2004: Jérôme Fagart; Grégory PINON; Marie-Edith Rafestin-Oblin
[Agonists and antagonists of mineralocorticoids. The relation between structure and activity].
Annales de cardiologie et d'angéiologie 2004;53(3):154-7.
2004: Grégory PINON; Jérôme Fagart; Anny Souque; Gilles Auzou; Alain Vandewalle; Marie-Edith Rafestin-Oblin
Identification of steroid ligands able to inactivate the mineralocorticoid receptor harboring the S810L mutation responsible for a severe form of hypertension.
Molecular and cellular endocrinology 2004;217(1-2):181-8.
2003: Brigitte Bocchi; Jérôme Fagart; Françoise Cluzeaud; Michèle Fay; Marie-Edith Rafestin-Oblin; Nicolette Farman
Glucocorticoid metabolism by 11-beta hydroxysteroid dehydrogenase type 2 modulates human mineralocorticoid receptor transactivation activity.
The Journal of steroid biochemistry and molecular biology 2003;84(2-3):239-44.
2003: Marie-Edith Rafestin-Oblin; Anny Souque; Brigitte Bocchi; Grégory PINON; Jérôme Fagart; Alain Vandewalle
The severe form of hypertension caused by the activating S810L mutation in the mineralocorticoid receptor is cortisone related.
Endocrinology 2003;144(2):528-33.
2002: Marie-Edith Rafestin-Oblin; Jérôme Fagart; Anny Souque; Cendrine Seguin; Marcelle Bens; Alain Vandewalle
11beta-hydroxyprogesterone acts as a mineralocorticoid agonist in stimulating Na+ absorption in mammalian principal cortical collecting duct cells.
Molecular pharmacology 2002;62(6):1306-13.
2000: Gilles Auzou; Jérôme Fagart; Anny Souque; C Hellal-Lévy; Jean-Marie Wurtz; Dino Moras; Marie-Edith Rafestin-Oblin
A single amino acid mutation of ala-773 in the mineralocorticoid receptor confers agonist properties to 11beta-substituted spirolactones.
Molecular pharmacology 2000;58(4):684-91.
2000: C Hellal-Levy; Jérôme Fagart; Anny Souque; Jean-Marie Wurtz; Dino Moras; Marie-Edith Rafestin-Oblin
Crucial role of the H11-H12 loop in stabilizing the active conformation of the human mineralocorticoid receptor.
Molecular endocrinology (Baltimore, Md.) 2000;14(8):1210-21.
2000: Jean-Marie Wurtz; B Guillot; Jérôme Fagart; Dino Moras; K Tietjen; M Schindler
A new model for 20-hydroxyecdysone and dibenzoylhydrazine binding: a homology modeling and docking approach.
Protein science : a publication of the Protein Society 2000;9(6):1073-84.
2000: C Hellal-Levy; Jérôme Fagart; Anny Souque; Marie-Edith Rafestin-Oblin
Mechanistic aspects of mineralocorticoid receptor activation.
Kidney international 2000;57(4):1250-5.
1999: C Hellal-Levy; B Couette; Jérôme Fagart; Anny Souque; C Gomez-Sanchez; Marie-Edith Rafestin-Oblin
Specific hydroxylations determine selective corticosteroid recognition by human glucocorticoid and mineralocorticoid receptors.
FEBS letters 1999;464(1-2):9-13.
1999: C Hellal-Levy; Jérôme Fagart; Anny Souque; Marie-Edith Rafestin-Oblin
[Corticosteroid hormones: mechanisms involved in the recognition of aldosterone by mineralocorticoid receptors].
Journal de la Société de biologie 1999;193(4-5):355-60.
1998: Jérôme Fagart; B Couette; Anny Souque; Elisabeth Davioud; Andrée Marquet; Marie-Edith Rafestin-Oblin
Photoaffinity labelling of the human mineralocorticoid receptor with steroids having a reactive group at position 3, 18 or 21.
Biochimica et biophysica acta 1998;1388(1):35-44.
1998: Jérôme Fagart; Jean-Marie Wurtz; Anny Souque; C Hellal-Levy; Dino Moras; Marie-Edith Rafestin-Oblin
Antagonism in the human mineralocorticoid receptor.
The EMBO journal 1998;17(12):3317-25.
1998: B Couette; Stéphan Jalaguier; C Hellal-Levy; B Lupo; Jérôme Fagart; Gilles Auzou; Marie-Edith Rafestin-Oblin
Folding requirements of the ligand-binding domain of the human mineralocorticoid receptor.
Molecular endocrinology (Baltimore, Md.) 1998;12(6):855-63.
1996: Elisabeth Davioud; Jérôme Fagart; Anny Souque; Marie-Edith Rafestin-Oblin; Andrée Marquet
New steroidal diazo ketones as potential photoaffinity labeling reagents for the mineralocorticoid receptor: synthesis and biological activities.
Journal of medicinal chemistry 1996;39(14):2860-4.
1996: B Couette; Jérôme Fagart; Stéphan Jalaguier; M Lombes; Anny Souque; Marie-Edith Rafestin-Oblin
Ligand-induced conformational change in the human mineralocorticoid receptor occurs within its hetero-oligomeric structure.
The Biochemical journal 1996;315 ( Pt 2)():421-7.
1996: Anny Souque; Jérôme Fagart; B Couette; Marie-Edith Rafestin-Oblin
Sulfhydryl groups are involved in the binding of agonists and antagonists to the human mineralocorticoid receptor.
The Journal of steroid biochemistry and molecular biology 1996;57(5-6):315-21.
1995: Anny Souque; Jérôme Fagart; B Couette; Elisabeth Davioud; Franck Sobrio; Andrée Marquet; Marie-Edith Rafestin-Oblin
The mineralocorticoid activity of progesterone derivatives depends on the nature of the C18 substituent.
Endocrinology 1995;136(12):5651-8.