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Ramin Faghih

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John Malysz; Jens Halvard Grønlien; David J Anderson; Monika Håkerud; Kirsten Thorin-Hagene; Hilde Ween; Caroline Wetterstrand; Jens Halvard Gronlien; Ramin Faghih; William H Bunnelle; Murali Gopalakrishnan
In vitro pharmacological characterization of a novel allosteric modulator of alpha 7 neuronal acetylcholine receptor, 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744), exhibiting unique pharmacological profile.
Ramin Faghih; Sujatha M Gopalakrishnan; Jens Halvard Gronlien; John Malysz; Jens Halvard Gronlien; Caroline Wetterstrand; Hilde Ween; Michael P Curtis; Kathy A Sarris; Gregory A Gfesser; Rachid El Kouhen; Holly M Robb; Richard J Radek; Kennan Marsh; William H Bunnelle; Murali Gopalakrishnan
Discovery of 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744) as a novel positive allosteric modulator of the alpha7 nicotinic acetylcholine receptor.
Ramin Faghih; Murali Gopalakrishnan; Clark A Briggs
Allosteric modulators of the alpha7 nicotinic acetylcholine receptor.

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2009: John Malysz; Jens Halvard Grønlien; David J Anderson; Monika Håkerud; Kirsten Thorin-Hagene; Hilde Ween; Caroline Wetterstrand; Jens Halvard Gronlien; Ramin Faghih; William H Bunnelle; Murali Gopalakrishnan
In vitro pharmacological characterization of a novel allosteric modulator of alpha 7 neuronal acetylcholine receptor, 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744), exhibiting unique pharmacological profile.
The Journal of pharmacology and experimental therapeutics 2009;330(1):257-67.
2009: Ramin Faghih; Sujatha M Gopalakrishnan; Jens Halvard Gronlien; John Malysz; Jens Halvard Gronlien; Caroline Wetterstrand; Hilde Ween; Michael P Curtis; Kathy A Sarris; Gregory A Gfesser; Rachid El Kouhen; Holly M Robb; Richard J Radek; Kennan Marsh; William H Bunnelle; Murali Gopalakrishnan
Discovery of 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744) as a novel positive allosteric modulator of the alpha7 nicotinic acetylcholine receptor.
Journal of medicinal chemistry 2009;52(10):3377-84.
2008: Ramin Faghih; Murali Gopalakrishnan; Clark A Briggs
Allosteric modulators of the alpha7 nicotinic acetylcholine receptor.
Journal of medicinal chemistry 2008;51(4):701-12.
2007: Ramin Faghih; Gregory A Gfesser; Murali Gopalakrishnan
Advances in the discovery of novel positive allosteric modulators of the alpha7 nicotinic acetylcholine receptor.
Recent patents on CNS drug discovery 2007;2(2):99-106.
2007: Marlon D Cowart; Gregory A Gfesser; Kaitlin E Browman; Ramin Faghih; Thomas R Miller; Ivan Milicic; John L Baranowski; Kathleen M Krueger; David G Witte; Angela L Molesky; Victoria A Komater; Michael J Buckley; Gilbert J Diaz; Gerard Gagne; Deliang Zhou; Xiaoqing Deng; Liping Pan; Ellen M Roberts; Marilyn S Diehl; Jill M Wetter; Kennan Marsh; Gerard B Fox; Jorge D Brioni; Timothy A Esbenshade; Arthur A Hancock
Novel heterocyclic-substituted benzofuran histamine H3 receptor antagonists: in vitro properties, drug-likeness, and behavioral activity.
Biochemical pharmacology 2007;73(8):1243-55.
2006: David G Witte; Betty B Yao; Thomas R Miller; Tracy L Carr; Steven C Cassar; Rahul Sharma; Ramin Faghih; Bruce W Surber; Timothy A Esbenshade; Arthur A Hancock; Kathleen M Krueger
Detection of multiple H3 receptor affinity states utilizing [3H]A-349821, a novel, selective, non-imidazole histamine H3 receptor inverse agonist radioligand.
British journal of pharmacology 2006;148(5):657-70.
2006: Betty B Yao; David G Witte; Thomas R Miller; Tracy L Carr; Chae Hee Kang; Steven C Cassar; Ramin Faghih; Youssef L Bennani; Bruce W Surber; Arthur A Hancock; Timothy A Esbenshade
Use of an inverse agonist radioligand [3H]A-317920 reveals distinct pharmacological profiles of the rat histamine H3 receptor.
Neuropharmacology 2006;50(4):468-78.
2005: Minghua Sun; Chen Zhao; Gregory A Gfesser; Christine Thiffault; Thomas R Miller; Kennan Marsh; Jill M Wetter; Michael Curtis; Ramin Faghih; Timothy A Esbenshade; Arthur A Hancock; Marlon D Cowart
Synthesis and SAR of 5-amino- and 5-(aminomethyl)benzofuran histamine H3 receptor antagonists with improved potency.
Journal of medicinal chemistry 2005;48(20):6482-90.
2005: Min Zhang; Michael Ballard; Liping Pan; Stanley Roberts; Ramin Faghih; Marlon D Cowart; Timothy A Esbenshade; Gerard B Fox; Michael W Decker; Arthur A Hancock; Lynne E Rueter
Lack of cataleptogenic potentiation with non-imidazole H3 receptor antagonists reveals potential drug-drug interactions between imidazole-based H3 receptor antagonists and antipsychotic drugs.
Brain research 2005;1045(1-2):142-9.
2005: Gregory A Gfesser; Ramin Faghih; Youssef L Bennani; Michael P Curtis; Timothy A Esbenshade; Arthur A Hancock; Marlon D Cowart
Structure-activity relationships of arylbenzofuran H3 receptor antagonists.
Bioorganic & medicinal chemistry letters 2005;15(10):2559-63.
2005: Timothy A Esbenshade; Betty B Yao; David G Witte; Tracy L Carr; Rahul Sharma; John L Baranowski; Kathleen M Krueger; Thomas R Miller; Bruce W Surber; Ramin Faghih; Arthur A Hancock
Use of novel, non-imidazole inverse agonist radioligands to define histamine H3 receptor pharmacology.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2005;54 Suppl 1():S46-7.
2005: Arthur A Hancock; Marilyn S Diehl; Thomas A Fey; Eugene N Bush; Ramin Faghih; Thomas R Miller; Kathleen M Krueger; John K Pratt; Marlon D Cowart; RW Dickinson; Robin Shapiro; Victoria Knourek-Segel; Brian A Droz; C A McDowell; G Krishna; Michael E Brune; Timothy A Esbenshade; Peer B Jacobson
Antiobesity evaluation of histamine H3 receptor (H3R) antagonist analogs of A-331440 with improved safety and efficacy.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2005;54 Suppl 1():S27-9.
2005: Marlon D Cowart; Ramin Faghih; Gregory A Gfesser; Michael Curtis; Minghua Sun; Chen Zhao; Youssef L Bennani; Jill M Wetter; Kennan Marsh; Thomas R Miller; K Krueger; Jia Bao Pan; Karla U Drescher; Gerard B Fox; Timothy A Esbenshade; Arthur A Hancock
Achievement of behavioral efficacy and improved potency in new heterocyclic analogs of benzofuran H3 antagonists.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2005;54 Suppl 1():S25-6.
2005: Gerard B Fox; Timothy A Esbenshade; Jia Bao Pan; Kaitlin E Browman; Min Zhang; Michael Ballard; Richard J Radek; Holly M Miner; Robert S Bitner; Kathleen M Krueger; Betty B Yao; Ramin Faghih; Lynne E Rueter; Victoria A Komater; Karla U Drescher; Michael J Buckley; James P Sullivan; Marlon D Cowart; Michael W Decker; Arthur A Hancock
Selective H3 receptor (H3R) blockade: broad efficacy in cognition and schizophrenia.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2005;54 Suppl 1():S23-4.
2005: Gerard B Fox; Timothy A Esbenshade; Jia Bao Pan; Richard J Radek; Kathleen M Krueger; Betty B Yao; Kaitlin E Browman; Michael J Buckley; Michael Ballard; Victoria A Komater; Holly M Miner; Min Zhang; Ramin Faghih; Lynne E Rueter; Robert S Bitner; Karla U Drescher; Jill M Wetter; Kennan Marsh; Martine Lemaire; Roger D Porsolt; Youssef L Bennani; James P Sullivan; Marlon D Cowart; Michael W Decker; Arthur A Hancock
Pharmacological properties of ABT-239 [4-(2-{2-[(2R)-2-Methylpyrrolidinyl]ethyl}-benzofuran-5-yl)benzonitrile]: II. Neurophysiological characterization and broad preclinical efficacy in cognition and schizophrenia of a potent and selective histamine H3 receptor antagonist.
The Journal of pharmacology and experimental therapeutics 2005;313(1):176-90.
2005: Marlon D Cowart; Ramin Faghih; Michael P Curtis; Gregory A Gfesser; Youssef L Bennani; Lawrence A Black; Liping Pan; Kennan Marsh; James P Sullivan; Timothy A Esbenshade; Gerard B Fox; Arthur A Hancock
4-(2-[2-(2(R)-methylpyrrolidin-1-yl)ethyl]benzofuran-5-yl)benzonitrile and related 2-aminoethylbenzofuran H3 receptor antagonists potently enhance cognition and attention.
Journal of medicinal chemistry 2005;48(1):38-55.
2004: Marlon D Cowart; Robert J Altenbach; Lawrence Black; Ramin Faghih; Chen Zhao; Arthur A Hancock
Medicinal chemistry and biological properties of non-imidazole histamine H3 antagonists.
Mini reviews in medicinal chemistry 2004;4(9):979-92.
2004: Arthur A Hancock; Marilyn S Diehl; Ramin Faghih; Eugene N Bush; Kathleen M Krueger; Gopala Krishna; Thomas R Miller; Denise M Wilcox; Phong Nguyen; John K Pratt; Marlon D Cowart; Timothy A Esbenshade; Peer B Jacobson
In vitro optimization of structure activity relationships of analogues of A-331440 combining radioligand receptor binding assays and micronucleus assays of potential antiobesity histamine H3 receptor antagonists.
Basic & clinical pharmacology & toxicology 2004;95(3):144-52.
2004: Timothy A Esbenshade; Gerard B Fox; Kathleen M Krueger; John L Baranowski; Thomas R Miller; Chae Hee Kang; Lynne I Denny; David G Witte; Betty B Yao; Jia Bao Pan; Ramin Faghih; Youssef L Bennani; Michael Williams; Arthur A Hancock
Pharmacological and behavioral properties of A-349821, a selective and potent human histamine H3 receptor antagonist.
Biochemical pharmacology 2004;68(5):933-45.
2004: Michael P Curtis; Wesley Dwight; John Pratt; Marlon D Cowart; Timothy A Esbenshade; Kathleen M Krueger; Gerard B Fox; Jia Bao Pan; Thomas G Pagano; Arthur A Hancock; Ramin Faghih; Youssef L Bennani
D-amino acid homopiperazine amides: discovery of A-320436, a potent and selective non-imidazole histamine H(3)-receptor antagonist.
Archiv der Pharmazie 2004;337(4):219-29.
2004: Arthur A Hancock; Youssef L Bennani; Eugene N Bush; Timothy A Esbenshade; Ramin Faghih; Gerard B Fox; Peer Jacobson; Victoria Knourek-Segel; Kathleen M Krueger; Merrill E Nuss; Jia Bao Pan; Robin Shapiro; David G Witte; Betty B Yao
Antiobesity effects of A-331440, a novel non-imidazole histamine H3 receptor antagonist.
European journal of pharmacology 2004;487(1-3):183-97.
2004: Ramin Faghih; Timothy A Esbenshade; Kathleen M Krueger; Betty B Yao; David G Witte; T M Miller; Chae Hee Kang; Gerard B Fox; Marlon D Cowart; Youssef L Bennani; Arthur A Hancock
Structure-activity relationships of A-331440: a new histamine-3 antagonist with anti-obesity properties.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2004;53 Suppl 1():S79-80.
2004: Betty B Yao; Rahul Sharma; Steven C Cassar; Ramin Faghih; Youssef L Bennani; Timothy A Esbenshade; Arthur A Hancock
Molecular and pharmacological characterization of the monkey histamine H(3) receptor.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2004;53 Suppl 1():S75-6.
2004: Marlon D Cowart; Ramin Faghih; Gregory A Gfesser; Michael Curtis; John K Pratt; Youssef L Bennani; Gerard B Fox; Timothy A Esbenshade; Arthur A Hancock
The medicinal chemistry of novel H(3) antagonists.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2004;53 Suppl 1():S69-70.
2004: Gerard B Fox; Jia Bao Pan; A M Lewis; Kaitlin E Browman; Victoria A Komater; Michael J Buckley; Peter Curzon; Richard J Radek; Ramin Faghih; Timothy A Esbenshade; Marlon D Cowart; Michael W Decker; Arthur A Hancock
Cognition enhancing effects of novel H(3) receptor (H(3)R) antagonists in several animal models.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2004;53 Suppl 1():S49-50.
2004: Arthur A Hancock; Eugene N Bush; Peer B Jacobson; Ramin Faghih; Timothy A Esbenshade
Histamine H(3) antagonists in models of obesity.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2004;53 Suppl 1():S47-8.
2004: Gregory A Gfesser; Henry Zhang; Jurgen Dinges; Gerard B Fox; Jia Bao Pan; Timothy A Esbenshade; Betty B Yao; David Witte; Thomas R Miller; Chae Hee Kang; Kathleen M Krueger; Youssef L Bennani; Arthur A Hancock; Ramin Faghih
Structure-activity relationships of non-imidazole H(3) receptor ligands. Part 3: 5-Substituted 3-phenyl-1,2,4-oxadiazoles as potent antagonists.
Bioorganic & medicinal chemistry letters 2004;14(3):673-6.
2003: Timothy A Esbenshade; Kathleen M Krueger; Thomas R Miller; Chae Hee Kang; Lynne I Denny; David G Witte; Betty B Yao; Gerard B Fox; Ramin Faghih; Youssef L Bennani; Michael Williams; Arthur A Hancock
Two novel and selective nonimidazole histamine H3 receptor antagonists A-304121 and A-317920: I. In vitro pharmacological effects.
The Journal of pharmacology and experimental therapeutics 2003;305(3):887-96.
2003: Gerard B Fox; Jia Bao Pan; Richard J Radek; Angela M Lewis; Robert S Bitner; Timothy A Esbenshade; Ramin Faghih; Youssef L Bennani; Michael Williams; Betty B Yao; Michael W Decker; Arthur A Hancock
Two novel and selective nonimidazole H3 receptor antagonists A-304121 and A-317920: II. In vivo behavioral and neurophysiological characterization.
The Journal of pharmacology and experimental therapeutics 2003;305(3):897-908.
2003: Ramin Faghih; Wesley Dwight; Jia Bao Pan; Gerard B Fox; Kathleen M Krueger; Timothy A Esbenshade; Jill M McVey; Kennan Marsh; Youssef L Bennani; Arthur A Hancock
Synthesis and SAR of aminoalkoxy-biaryl-4-carboxamides: novel and selective histamine H3 receptor antagonists.
Bioorganic & medicinal chemistry letters 2003;13(7):1325-8.
2003: Ramin Faghih; Kathleen M Phelan; Timothy A Esbenshade; Thomas R Miller; Chae Hee Kang; Kathleen M Krueger; Betty B Yao; Gerard B Fox; Youssef L Bennani; Arthur A Hancock
D-alanine piperazine-amides: novel non-imidazole antagonists of the histamine H3 receptor.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2003;52 Suppl 1():S47-8.
2003: Betty B Yao; David G Witte; Thomas R Miller; Kathleen M Krueger; Tracy L Carr; Chae Hee Kang; Ramin Faghih; Youssef L Bennani; Timothy A Esbenshade; Arthur A Hancock
In vitro pharmacological properties of two novel non-imidazole H3 receptor (H3R) antagonists.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2003;52 Suppl 1():S45-6.
2003: Gerard B Fox; Jia Bao Pan; Ramin Faghih; Timothy A Esbenshade; A Lewis; Robert S Bitner; Lawrence A Black; Youssef L Bennani; Michael W Decker; Arthur A Hancock
Identification of novel H3 receptor (H3R) antagonists with cognition enhancing properties in rats.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2003;52 Suppl 1():S31-2.
2002: Ramin Faghih; Wesley Dwight; Anil Vasudevan; Jurgen Dinges; Scott E Conner; Timothy A Esbenshade; Youssef L Bennani; Arthur A Hancock
Aminoalkoxybiphenylnitriles as histamine-3 receptor ligands.
Bioorganic & medicinal chemistry letters 2002;12(21):3077-9.
2002: Anil Vasudevan; Scott E Conner; Robert Gentles; Ramin Faghih; Huaqing Liu; Wesley Dwight; Lynne Ireland; Chae Hee Kang; Timothy A Esbenshade; Youssef L Bennani; Arthur A Hancock
Synthesis and evaluation of potent pyrrolidine H(3) antagonists.
Bioorganic & medicinal chemistry letters 2002;12(21):3055-8.
2002: Ramin Faghih; Wesley Dwight; Lawrence Black; Huaqing Liu; Robert Gentles; Kathleen M Phelan; Timothy A Esbenshade; Lynne Ireland; Thomas R Miller; Chae Hee Kang; Kathleen M Krueger; Gerard B Fox; Arthur A Hancock; Youssef L Bennani
Structure-activity relationships of non-imidazole H(3) receptor ligands. Part 2: binding preference for D-amino acids motifs.
Bioorganic & medicinal chemistry letters 2002;12(15):2035-7.
2002: Ramin Faghih; Wesley Dwight; Robert Gentles; Kathleen M Phelan; Timothy A Esbenshade; Lynne Ireland; Thomas R Miller; Chae Hee Kang; Gerard B Fox; Sujatha M Gopalakrishnan; Arthur A Hancock; Youssef L Bennani
Structure-activity relationships of non-imidazole H(3) receptor ligands. Part 1.
Bioorganic & medicinal chemistry letters 2002;12(15):2031-4.
2002: Gerard B Fox; Jia Bao Pan; Timothy A Esbenshade; Robert S Bitner; Arthur L Nikkel; Tom Miller; Chae Hee Kang; Youssef L Bennani; Lawrence A Black; Ramin Faghih; Arthur A Hancock; Michael W Decker
Differential in vivo effects of H3 receptor ligands in a new mouse dipsogenia model.
Pharmacology, biochemistry, and behavior 2002;72(3):741-50.
2002: Gerard B Fox; Jia Bao Pan; Timothy A Esbenshade; Youssef L Bennani; Lawrence A Black; Ramin Faghih; Arthur A Hancock; Michael W Decker
Effects of histamine H(3) receptor ligands GT-2331 and ciproxifan in a repeated acquisition avoidance response in the spontaneously hypertensive rat pup.
Behavioural brain research 2002;131(1-2):151-61.
2000: V E Cowles; Hugh Nellans; Terese R Seifert; L M Besecke; Jason A Segreti; Kurt M Mohning; Ramin Faghih; Marleen Verlinden; Craig D Wegner
Effect of novel motilide ABT-229 versus erythromycin and cisapride on gastric emptying in dogs.
The Journal of pharmacology and experimental therapeutics 2000;293(3):1106-11.
1998: Ramin Faghih; Paul Lartey; Hugh Nellans; L Seif; C Burnell-Curty; Larry Klein; P Thomas; A Petersen; A Borre; Thomas G Pagano; Ki H Kim; Matthew Heindel; Youssef L Bennani; Jacob J Plattner
Synthesis of 9-deoxo-4''-deoxy-6,9-epoxyerythromycin derivatives: novel and acid-stable motilides.
Journal of medicinal chemistry 1998;41(18):3402-8.
1998: Ramin Faghih; Hugh Nellans; Paul Lartey; A Petersen; Kennan Marsh; Youssef L Bennani; Jacob J Plattner
Preparation of 9-deoxo-4"-deoxy-6,9-epoxyerythromycin lactams "motilactides": potent and orally active prokinetic agents.
Bioorganic & medicinal chemistry letters 1998;8(7):805-10.
1996: Ramin Faghih; L Freiberg; J Leonard; Jacob J Plattner; Paul Lartey
Synthesis and antibacterial activity of 6-deoxysporeamicin A.
The Journal of antibiotics 1996;49(5):493-5.
1995: Paul Lartey; Ramin Faghih; T Pagano; Hugh Nellans; A Petersen; Jacob J Plattner
Stereoselective deoxygenation of erythromycin A at C-12: effect of structure and conformation on prokinetic activity.
The Journal of antibiotics 1995;48(7):730-2.
1995: Paul Lartey; Hugh Nellans; Ramin Faghih; A Petersen; C M Edwards; L Freiberg; S Quigley; Kennan Marsh; Larry Klein; Jacob J Plattner
Synthesis of 4"-deoxy motilides: identification of a potent and orally active prokinetic drug candidate.
Journal of medicinal chemistry 1995;38(10):1793-8.
1992: Paul Lartey; S L DeNinno; Ramin Faghih; D J Hardy; J J Clement; Jacob J Plattner
Synthesis and activity of C-21 alkylamino derivatives of (9R)-erythromycylamine.
The Journal of antibiotics 1992;45(3):380-5.
1991: Paul Lartey; S L DeNinno; Ramin Faghih; D J Hardy; J J Clement; Jacob J Plattner; R L Stephens
Synthesis and antibacterial activities of C-21 functionalized derivatives of (9R)-9-amino-9-deoxoerythromycins A and B.
Journal of medicinal chemistry 1991;34(12):3390-5.
1990: Ramin Faghih; M Buytendorp; R Stephens; D Hardy; Jacob J Plattner; Paul Lartey
Synthesis and antibacterial activity of (9S)-9-dihydroclarithromycin.
The Journal of antibiotics 1990;43(10):1334-6.