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James Fagin

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Ian Ganly; Ronald A Ghossein; Kasthuri Kannan; Yupu Liang; Qianxing Mo; Luc G Morris; Julio Ricarte Filho; Nicholas Socci; Stephanie Eng; James A Fagin; Timothy Chan
Genomic dissection of hurthle cell carcinoma reveals a unique class of thyroid malignancy.
Mona M Sabra; R Michael Tuttle; J M Dominguez; Ronald A Ghossein; Ravinder K Grewal; S M Larson; James A Fagin
Clinical outcomes and molecular profile of differentiated thyroid cancers with radioiodine-avid distant metastases.
Cristina Montero-Conde; Neal Rosen; Sergio Ruiz-Llorente; Mabel Ryder; Eric J Sherman; Agnes Viale; Jose M Dominguez; Ronald A Ghossein; Jeffrey A Knauf; James A Fagin
Relief of Feedback Inhibition of HER3 Transcription by RAF and MEK Inhibitors Attenuates Their Antitumor Effects in BRAF-Mutant Thyroid Carcinomas.

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2013: Ian Ganly; Ronald A Ghossein; Kasthuri Kannan; Yupu Liang; Qianxing Mo; Luc G Morris; Julio Ricarte Filho; Nicholas Socci; Stephanie Eng; James A Fagin; Timothy Chan
Genomic dissection of hurthle cell carcinoma reveals a unique class of thyroid malignancy.
The Journal of clinical endocrinology and metabolism 2013;98(5):E962-72.
2013: Mona M Sabra; R Michael Tuttle; J M Dominguez; Ronald A Ghossein; Ravinder K Grewal; S M Larson; James A Fagin
Clinical outcomes and molecular profile of differentiated thyroid cancers with radioiodine-avid distant metastases.
The Journal of clinical endocrinology and metabolism 2013;98(5):E829-36.
2013: Cristina Montero-Conde; Neal Rosen; Sergio Ruiz-Llorente; Mabel Ryder; Eric J Sherman; Agnes Viale; Jose M Dominguez; Ronald A Ghossein; Jeffrey A Knauf; James A Fagin
Relief of Feedback Inhibition of HER3 Transcription by RAF and MEK Inhibitors Attenuates Their Antitumor Effects in BRAF-Mutant Thyroid Carcinomas.
Cancer discovery 2013;3(5):520-33.
2013: Mabel Ryder; Ronald Ghossein; Matti Gild; Tobias M Hohl; Johanna A Joyce; Jeff Knauf; Eric Pamer; James A Fagin
Genetic and pharmacological targeting of CSF-1/CSF-1R inhibits tumor-associated macrophages and impairs BRAF-induced thyroid cancer progression.
PloS one 2013;8(1):e54302.
2012: Piro Lito; Taha Merghoub; Poulikos I Poulikakos; Christine A Pratilas; Margaret K Callahan; Sarat Chandarlapaty; Elisa de Stanchina; James A Fagin; Ensar Halilovic; Alan Huang; Eric W Joseph; Madhavi Tadi; Jedd D Wolchok; Wai Lin Wong; Matthew Zubrowski; Neal Rosen
Relief of profound feedback inhibition of mitogenic signaling by RAF inhibitors attenuates their activity in BRAFV600E melanomas.
Cancer cell 2012;22(5):668-82.
2012: Julio Ricarte-Filho; Michael Rivera; Ashok Shaha; R Michael Tuttle; James A Fagin; Weimin Fu; Ian Ganly; Nora Katabi; Ronald A Ghossein
Papillary thyroid carcinomas with cervical lymph node metastases can be stratified into clinically relevant prognostic categories using oncogenic BRAF, the number of nodal metastases, and extra-nodal extension.
Thyroid : official journal of the American Thyroid Association 2012;22(6):575-84.
2012: Julio C Ricarte-Filho; Mabel Ryder; Shunichi Yamashita; Ronald A Ghossein; Marc Ladanyi; Christopher Lau; Michiko Matsuse; Norisato Mitsutake; Eijun Nishihara; James A Fagin
Absence of common activating mutations of the epidermal growth factor receptor gene in thyroid cancers from American and Japanese patients.
International journal of cancer. Journal international du cancer 2012;130(9):2215-7; author reply 2217-8.
2012: Lars Wichmann Madsen; Katia Manova-Todorova; Anne Marie Moelck; Niels C Berg Nyborg; Andrew Pilling; Ingrid Sjögren; Sushil Vundavalli; Anne Sietske de Boer; Lotte Bjerre Knudsen; Lene Andersen; Søren Andersen; Afsar Barlas; Carsten Gotfredsen; Jeffrey A Knauf; James A Fagin
GLP-1 receptor agonists and the thyroid: C-cell effects in mice are mediated via the GLP-1 receptor and not associated with RET activation.
Endocrinology 2012;153(3):1538-47.
2011: Geneviève Rondeau; James A Fagin; Stephanie Fish; Lucy E Hann; R Michael Tuttle
Ultrasonographically detected small thyroid bed nodules identified after total thyroidectomy for differentiated thyroid cancer seldom show clinically significant structural progression.
Thyroid : official journal of the American Thyroid Association 2011;21(8):845-53.
2011: H Tala; James A Fagin; S M Larson; R Robbins; R Michael Tuttle
Five-year survival is similar in thyroid cancer patients with distant metastases prepared for radioactive iodine therapy with either thyroid hormone withdrawal or recombinant human TSH.
The Journal of clinical endocrinology and metabolism 2011;96(7):2105-11.
2011: Donata Vitagliano; Valentina De Falco; Anna Tamburrino; Sabrina Coluzzi; Giancarlo Troncone; Gennaro Chiappetta; Fortunato Ciardiello; Giampaolo Tortora; James A Fagin; Anderson J Ryan; Francesca Carlomagno; Massimo Santoro
The tyrosine kinase inhibitor ZD6474 blocks proliferation of RET mutant medullary thyroid carcinoma cells.
Endocrine-related cancer 2011;18(1):1-11.
2011: Aime T Franco; Roberta Malaguarnera; Samuel Refetoff; Xiao-Hui Liao; Emma Lundsmith; Shioko Kimura; Catrin Pritchard; Richard Marais; Terry F Davies; Lee S Weinstein; Min Chen; Neal Rosen; Ronald A Ghossein; Jeffrey A Knauf; James A Fagin
Thyrotrophin receptor signaling dependence of Braf-induced thyroid tumor initiation in mice.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(4):1615-20.
2010: R Michael Tuttle; Hernan Tala; Jatin P Shah; Rebecca Leboeuf; Ronald A Ghossein; Mithat Gonen; Matvey Brokhin; Gal Omry; James A Fagin; Ashok Shaha
Estimating risk of recurrence in differentiated thyroid cancer after total thyroidectomy and radioactive iodine remnant ablation: using response to therapy variables to modify the initial risk estimates predicted by the new American Thyroid Association staging system.
Thyroid : official journal of the American Thyroid Association 2010;20(12):1341-9.
2010: Michael Rivera; Julio Ricarte-Filho; R Michael Tuttle; Ian Ganly; Ashok Shaha; Jeffrey Knauf; James A Fagin; Ronald A Ghossein
Molecular, morphologic, and outcome analysis of thyroid carcinomas according to degree of extrathyroid extension.
Thyroid : official journal of the American Thyroid Association 2010;20(10):1085-93.
2010: Michael Rivera; Julio Ricarte-Filho; Jeff Knauf; Ashok Shaha; Michael Tuttle; James A Fagin; Ronald A Ghossein
Molecular genotyping of papillary thyroid carcinoma follicular variant according to its histological subtypes (encapsulated vs infiltrative) reveals distinct BRAF and RAS mutation patterns.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2010;23(9):1191-200.
2010: Manickam Janakiraman; Efsevia Vakiani; Zhaoshi Zeng; Christine A Pratilas; Barry S Taylor; Dhananjay Chitale; Ensar Halilovic; Manda Wilson; Kety Huberman; Julio Cezar Ricarte Filho; Yogindra Persaud; Douglas A Levine; James A Fagin; Suresh C Jhanwar; John M Mariadason; Alex E Lash; Marc Ladanyi; Leonard B Saltz; Adriana Heguy; Philip B Paty; David B Solit
Genomic and biological characterization of exon 4 KRAS mutations in human cancer.
Cancer research 2010;70(14):5901-11.
2010: James A Fagin; R Michael Tuttle; David G Pfister
Harvesting the low-hanging fruit: kinase inhibitors for therapy of advanced medullary and nonmedullary thyroid cancer.
The Journal of clinical endocrinology and metabolism 2010;95(6):2621-4.
2010: Michael Rivera; Julio Ricarte-Filho; Snehal G Patel; Michael Tuttle; Ashok Shaha; Jatin P Shah; James A Fagin; Ronald A Ghossein
Encapsulated thyroid tumors of follicular cell origin with high grade features (high mitotic rate/tumor necrosis): a clinicopathologic and molecular study.
Human pathology 2010;41(2):172-80.
2010: Katherine A Rauen; Lisa Schoyer; Frank McCormick; Angela E Lin; Judith E Allanson; David A Stevenson; Karen W Gripp; Giovanni Neri; John C Carey; Eric Legius; Marco Tartaglia; Suzanne Schubbert; Amy E Roberts; Bruce D Gelb; Kevin Shannon; David H Gutmann; Martin McMahon; Carmen Guerra; James A Fagin; Benjamin Yu; Yoko Aoki; Benjamin G Neel; Allan Balmain; Richard R Drake; Garry P Nolan; Martin Zenker; Gideon Bollag; Judith Leopold; Jackson B Gibbs; Alcino J Silva; E Elizabeth Patton; David H Viskochil; Mark W Kieran; Bruce R Korf; Randi J Hagerman; Roger J Packer; Teri Melese
Proceedings from the 2009 genetic syndromes of the Ras/MAPK pathway: From bedside to bench and back.
American journal of medical genetics. Part A 2010;152A(1):4-24.
2009: Selvaraju Veeriah; Cameron Brennan; Shasha Meng; Bhuvanesh Singh; James A Fagin; David B Solit; Philip B Paty; Dan Rohle; Igor Vivanco; Juliann Chmielecki; William Pao; Marc Ladanyi; William L Gerald; Linda Liau; Timothy C Cloughesy; Paul Mischel; Chris Sander; Barry Taylor; Nikolaus Schultz; John Major; Adriana Heguy; Fang Fang; Ingo K Mellinghoff; Timothy Chan
The tyrosine phosphatase PTPRD is a tumor suppressor that is frequently inactivated and mutated in glioblastoma and other human cancers.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(23):9435-40.
2009: R Michael Tuttle; James A Fagin
Can risk-adapted treatment recommendations replace the 'one size fits all' approach for early-stage thyroid cancer patients?
Oncology (Williston Park, N.Y.) 2009;23(7):592, 600, 603.
2009: Julio C Ricarte-Filho; Mabel M Ryder; Dhananjay A Chitale; Michael Rivera; Adriana Heguy; Marc Ladanyi; Manickam Janakiraman; David B Solit; Jeffrey A Knauf; R Michael Tuttle; Ronald A Ghossein; James A Fagin
Mutational profile of advanced primary and metastatic radioactive iodine-refractory thyroid cancers reveals distinct pathogenetic roles for BRAF, PIK3CA, and AKT1.
Cancer research 2009;69(11):4885-93.
2009: Yuri E Nikiforov; David L Steward; Toni M Robinson-Smith; Bryan R Haugen; Joshua Klopper; Zhaowen Zhu; James A Fagin; Mercedes Falciglia; Katherine Weber; Marina N Nikiforova
Molecular testing for mutations in improving the fine-needle aspiration diagnosis of thyroid nodules.
The Journal of clinical endocrinology and metabolism 2009;94(6):2092-8.
2009: Xu Chen; Norisato Mitsutake; Krista LaPerle; Nagako Akeno; Pat Zanzonico; Valerie A Longo; Shin Mitsutake; Edna T Kimura; Hartmut Geiger; Eugenio Santos; Hans-Guido Wendel; Aime Franco; Jeffrey A Knauf; James A Fagin
Endogenous expression of Hras(G12V) induces developmental defects and neoplasms with copy number imbalances of the oncogene.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(19):7979-84.
2009: Jeffrey A Knauf; James A Fagin
Role of MAPK pathway oncoproteins in thyroid cancer pathogenesis and as drug targets.
Current opinion in cell biology 2009;21(2):296-303.
2008: James A Fagin; Nicholas Mitsiades
Molecular pathology of thyroid cancer: diagnostic and clinical implications.
Best practice & research. Clinical endocrinology & metabolism 2008;22(6):955-69.
2008: Mabel M Ryder; Ronald A Ghossein; Julio C M Ricarte-Filho; Jeffrey A Knauf; James A Fagin
Increased density of tumor-associated macrophages is associated with decreased survival in advanced thyroid cancer.
Endocrine-related cancer 2008;15(4):1069-74.
2008: Rebecca E Schweppe; Joshua Klopper; Christopher Korch; Umarani Pugazhenthi; Miriam Benezra; Jeffrey A Knauf; James A Fagin; Laura A Marlow; John A Copland; Robert C Smallridge; Bryan R Haugen
Deoxyribonucleic acid profiling analysis of 40 human thyroid cancer cell lines reveals cross-contamination resulting in cell line redundancy and misidentification.
The Journal of clinical endocrinology and metabolism 2008;93(11):4331-41.
2008: David G Pfister; James A Fagin
Refractory thyroid cancer: a paradigm shift in treatment is not far off.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008;26(29):4701-4.
2008: Mickey Croyle; Nagako Akeno; Jeffrey A Knauf; Doriano Fabbro; Xu Chen; Jacqueline E Baumgartner; Heidi A Lane; James A Fagin
RET/PTC-induced cell growth is mediated in part by epidermal growth factor receptor (EGFR) activation: evidence for molecular and functional interactions between RET and EGFR.
Cancer research 2008;68(11):4183-91.
2008: Rebecca Leboeuf; Jacqueline E Baumgartner; Miriam Benezra; Roberta Malaguarnera; David B Solit; Christine A Pratilas; Neal Rosen; Jeffrey A Knauf; James A Fagin
BRAFV600E mutation is associated with preferential sensitivity to mitogen-activated protein kinase kinase inhibition in thyroid cancer cell lines.
The Journal of clinical endocrinology and metabolism 2008;93(6):2194-201.
2007: James G Simmons; Y Ling; Heather R Wilkins; C Randall Fuller; Augustine D'ercole; James A Fagin; P Kay Lund
Cell-specific effects of insulin receptor substrate-1 deficiency on normal and IGF-I-mediated colon growth.
American journal of physiology. Gastrointestinal and liver physiology 2007;293(5):G995-1003.
2007: Nagako Akeno-Stuart; Mickey Croyle; Jeffrey A Knauf; Roberta Malaguarnera; Donata Vitagliano; Massimo Santoro; Christine Stephan; Konstantina Grosios; Markus Wartmann; Robert Cozens; Giorgio Caravatti; Doriano Fabbro; Heidi A Lane; James A Fagin
The RET kinase inhibitor NVP-AST487 blocks growth and calcitonin gene expression through distinct mechanisms in medullary thyroid cancer cells.
Cancer research 2007;67(14):6956-64.
2007: James A Fagin; Laura S Ward; Edna T Kimura
[Thyroid cancer: past, present and future].
Arquivos brasileiros de endocrinologia e metabologia 2007;51(5):641-2.
2007: Mabel M Ryder; Yuri E Nikiforov; James A Fagin
Follicular variant papillary thyroid carcinoma arising within an ovarian teratoma.
Thyroid : official journal of the American Thyroid Association 2007;17(2):179-80.
2007: James A Fagin
The Jeremiah Metzger Lecture: intelligent design of cancer therapy: trials and tribulations.
Transactions of the American Clinical and Climatological Association 2007;118():253-61.
2006: Cleo Mesa; mana mirza; Norisato Mitsutake; Maureen Sartor; Mario Medvedovic; Craig R Tomlinson; Jeffrey A Knauf; Georg F Weber; James A Fagin
Conditional activation of RET/PTC3 and BRAFV600E in thyroid cells is associated with gene expression profiles that predict a preferential role of BRAF in extracellular matrix remodeling.
Cancer research 2006;66(13):6521-9.
2006: Lionel Groussin; James A Fagin
Significance of BRAF mutations in papillary thyroid carcinoma: prognostic and therapeutic implications.
Nature clinical practice. Endocrinology & metabolism 2006;2(4):180-1.
2006: Bin Ouyang; Jeffrey A Knauf; Eric P Smith; Lei Zhang; Tim Ramsey; Naeem Yusuff; David Batt; James A Fagin
Inhibitors of Raf kinase activity block growth of thyroid cancer cells with RET/PTC or BRAF mutations in vitro and in vivo.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(6):1785-93.
2006: Jeffrey A Knauf; Bin Ouyang; Erik S Knudsen; Kenji Fukasawa; George Babcock; James A Fagin
Oncogenic RAS induces accelerated transition through G2/M and promotes defects in the G2 DNA damage and mitotic spindle checkpoints.
The Journal of biological chemistry 2006;281(7):3800-9.
2006: Norisato Mitsutake; Makoto Miyagishi; Shin Mitsutake; Nagako Akeno; Cleo Mesa; Jeffrey A Knauf; Lei Zhang; Kazunari Taira; James A Fagin
BRAF mediates RET/PTC-induced mitogen-activated protein kinase activation in thyroid cells: functional support for requirement of the RET/PTC-RAS-BRAF pathway in papillary thyroid carcinogenesis.
Endocrinology 2006;147(2):1014-9.
2005: Efisio Puxeddu; Jeffrey A Knauf; Maureen Sartor; Norisato Mitsutake; Eric P Smith; Mario Medvedovic; Craig R Tomlinson; Sonia Moretti; James A Fagin
RET/PTC-induced gene expression in thyroid PCCL3 cells reveals early activation of genes involved in regulation of the immune response.
Endocrine-related cancer 2005;12(2):319-34.
2005: Jeffrey A Knauf; Xiaolan Ma; Eric P Smith; Lei Zhang; Norisato Mitsutake; Xiao-Hui Liao; Samuel Refetoff; Yuri E Nikiforov; James A Fagin
Targeted expression of BRAFV600E in thyroid cells of transgenic mice results in papillary thyroid cancers that undergo dedifferentiation.
Cancer research 2005;65(10):4238-45.
2005: Raffaele Ciampi; Jeffrey A Knauf; Hartmut M Rabes; James A Fagin; Yuri E Nikiforov
BRAF kinase activation via chromosomal rearrangement in radiation-induced and sporadic thyroid cancer.
Cell cycle (Georgetown, Tex.) 2005;4(4):547-8.
2005: Norisato Mitsutake; Jeffrey A Knauf; Shin Mitsutake; Cleo Mesa; Lei Zhang; James A Fagin
Conditional BRAFV600E expression induces DNA synthesis, apoptosis, dedifferentiation, and chromosomal instability in thyroid PCCL3 cells.
Cancer research 2005;65(6):2465-73.
2005: Efisio Puxeddu; Guisheng Zhao; James R Stringer; Mario Medvedovic; Sonia Moretti; James A Fagin
Characterization of novel non-clonal intrachromosomal rearrangements between the H4 and PTEN genes (H4/PTEN) in human thyroid cell lines and papillary thyroid cancer specimens.
Mutation research 2005;570(1):17-32.
2005: James A Fagin
Genetics of papillary thyroid cancer initiation: implications for therapy.
Transactions of the American Clinical and Climatological Association 2005;116():259-69; discussion 269-71.
2005: Raffaele Ciampi; Jeffrey A Knauf; Roswitha Kerler; Manoj Gandhi; Zhaowen Zhu; Marina N Nikiforova; Hartmut M Rabes; James A Fagin; Yuri E Nikiforov
Oncogenic AKAP9-BRAF fusion is a novel mechanism of MAPK pathway activation in thyroid cancer.
The Journal of clinical investigation 2005;115(1):94-101.
2005: S Sanz; Jolanta B Pucilowska; S Liu; Carlos M Rodríguez-Ortigosa; P Kay Lund; David A Brenner; C Randall Fuller; James G Simmons; A Pardo; María L Martínez-Chantar; James A Fagin; Jesús Prieto
Expression of insulin-like growth factor I by activated hepatic stellate cells reduces fibrogenesis and enhances regeneration after liver injury.
Gut 2005;54(1):134-41.
2004: James A Fagin
How thyroid tumors start and why it matters: kinase mutants as targets for solid cancer pharmacotherapy.
The Journal of endocrinology 2004;183(2):249-56.
2004: Giuliana Salvatore; Riccardo Giannini; Pinuccia Faviana; Alessia Caleo; Ilenia Migliaccio; James A Fagin; Yuri E Nikiforov; Giancarlo Troncone; Lucio Palombini; Fulvio Basolo; Massimo Santoro
Analysis of BRAF point mutation and RET/PTC rearrangement refines the fine-needle aspiration diagnosis of papillary thyroid carcinoma.
The Journal of clinical endocrinology and metabolism 2004;89(10):5175-80.
2004: James A Fagin
Challenging dogma in thyroid cancer molecular genetics--role of RET/PTC and BRAF in tumor initiation.
The Journal of clinical endocrinology and metabolism 2004;89(9):4264-6.
2004: Andrew W Knott; Russell J Juno; Marcus D Jarboe; Sherri A Profitt; Christopher R Erwin; Eric P Smith; James A Fagin; Brad W Warner
Smooth muscle overexpression of IGF-I induces a novel adaptive response to small bowel resection.
American journal of physiology. Gastrointestinal and liver physiology 2004;287(3):G562-70.
2004: Marina N Nikiforova; Raffaele Ciampi; Giuliana Salvatore; Massimo Santoro; Manoj Gandhi; Jeffrey A Knauf; Gerry A Thomas; Steve Jeremiah; Tetyana I Bogdanova; Mykola D Tronko; James A Fagin; Yuri E Nikiforov
Low prevalence of BRAF mutations in radiation-induced thyroid tumors in contrast to sporadic papillary carcinomas.
Cancer letters 2004;209(1):1-6.
2004: Edna T Kimura; Vanessa Vanvooren; Jacqueline Van Sande; Yuri E Nikiforov; James A Fagin
Autonomously functioning thyroid nodules are not associated with BRAF mutations.
Clinical endocrinology 2004;60(3):394-6.
2003: Efisio Puxeddu; Norisato Mitsutake; Jeffrey A Knauf; Sonia Moretti; Hei W Kim; Karen A Seta; Diane E Brockman; Leslie Myatt; David E Millhorn; James A Fagin
Microsomal prostaglandin E2 synthase-1 is induced by conditional expression of RET/PTC in thyroid PCCL3 cells through the activation of the MEK-ERK pathway.
The Journal of biological chemistry 2003;278(52):52131-8.
2003: Marina N Nikiforova; Edna T Kimura; Manoj Gandhi; Paul Williams Biddinger; Jeffrey A Knauf; Fulvio Basolo; Zhaowen Zhu; Riccardo Giannini; Giuliana Salvatore; Alfredo Fusco; Massimo Santoro; James A Fagin; Yuri E Nikiforov
BRAF mutations in thyroid tumors are restricted to papillary carcinomas and anaplastic or poorly differentiated carcinomas arising from papillary carcinomas.
The Journal of clinical endocrinology and metabolism 2003;88(11):5399-404.
2003: Jeffrey A Knauf; Bin Ouyang; Mickey Croyle; Edna Kimura; James A Fagin
Acute expression of RET/PTC induces isozyme-specific activation and subsequent downregulation of PKCepsilon in PCCL3 thyroid cells.
Oncogene 2003;22(44):6830-8.
2003: Jeffrey A Knauf; Hiroaki Kuroda; Saswata Basu; James A Fagin
RET/PTC-induced dedifferentiation of thyroid cells is mediated through Y1062 signaling through SHC-RAS-MAP kinase.
Oncogene 2003;22(28):4406-12.
2003: Jianwei Wang; Jeffrey A Knauf; Saswata Basu; Efisio Puxeddu; Hiroaki Kuroda; Massimo Santoro; Alfredo Fusco; James A Fagin
Conditional expression of RET/PTC induces a weak oncogenic drive in thyroid PCCL3 cells and inhibits thyrotropin action at multiple levels.
Molecular endocrinology (Baltimore, Md.) 2003;17(7):1425-36.
2003: Edna T Kimura; Marina N Nikiforova; Zhaowen Zhu; Jeffrey A Knauf; Yuri E Nikiforov; James A Fagin
High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma.
Cancer research 2003;63(7):1454-7.
2003: Maria Domenica Castellone; Anna Maria Cirafici; Gabriella De Vita; Valentina De Falco; Luca Malorni; Giovanni Tallini; James A Fagin; Alfredo Fusco; Rosa Marina Melillo; Massimo Santoro
Ras-mediated apoptosis of PC CL 3 rat thyroid cells induced by RET/PTC oncogenes.
Oncogene 2003;22(2):246-55.
2002: Kristen L Williams; C Randall Fuller; James A Fagin; P Kay Lund
Mesenchymal IGF-I overexpression: paracrine effects in the intestine, distinct from endocrine actions.
American journal of physiology. Gastrointestinal and liver physiology 2002;283(4):G875-85.
2002: Mingyu Zhang; Eric P Smith; Hiroaki Kuroda; Walter Banach; Steven D Chernausek; James A Fagin
Targeted expression of a protease-resistant IGFBP-4 mutant in smooth muscle of transgenic mice results in IGFBP-4 stabilization and smooth muscle hypotrophy.
The Journal of biological chemistry 2002;277(24):21285-90.
2002: James A Fagin
Perspective: lessons learned from molecular genetic studies of thyroid cancer--insights into pathogenesis and tumor-specific therapeutic targets.
Endocrinology 2002;143(6):2025-8.
2002: Jeffrey A Knauf; Laura S Ward; Yuri E Nikiforov; Marina N Nikiforova; Efisio Puxeddu; Mario Medvedovic; Tamar Liron; Daria Mochly-Rosen; James A Fagin
Isozyme-specific abnormalities of PKC in thyroid cancer: evidence for post-transcriptional changes in PKC epsilon.
The Journal of clinical endocrinology and metabolism 2002;87(5):2150-9.
2002: James A Fagin
Minireview: branded from the start-distinct oncogenic initiating events may determine tumor fate in the thyroid.
Molecular endocrinology (Baltimore, Md.) 2002;16(5):903-11.
2002: Bin Ouyang; Jeffrey A Knauf; Kenneth B Ain; Benjamin Nacev; James A Fagin
Mechanisms of aneuploidy in thyroid cancer cell lines and tissues: evidence for mitotic checkpoint dysfunction without mutations in BUB1 and BUBR1.
Clinical endocrinology 2002;56(3):341-50.
2001: Eric P Smith; A Kamyar; W Niu; J Wang; B Cercek; Steven D Chernausek; James A Fagin
IGF-binding protein-4 expression and IGF-binding protein-4 protease activity are regulated coordinately in smooth muscle during postnatal development and after vascular injury.
Endocrinology 2001;142(10):4420-7.
2001: Binghua Zhu; G Zhao; David P Witte; David Y Hui; James A Fagin
Targeted overexpression of IGF-I in smooth muscle cells of transgenic mice enhances neointimal formation through increased proliferation and cell migration after intraarterial injury.
Endocrinology 2001;142(8):3598-606.
2001: Efisio Puxeddu; James A Fagin
Genetic markers in thyroid neoplasia.
Endocrinology and metabolism clinics of North America 2001;30(2):493-513, x.
2001: G Zhao; Roy L Sutliff; Craig S Weber; J Wang; J Lorenz; Richard J Paul; James A Fagin
Smooth muscle-targeted overexpression of insulin-like growth factor I results in enhanced vascular contractility.
Endocrinology 2001;142(2):623-32.
2001: James A Fagin
[Thyroid cancer: epidemiology and predisposing mechanisms due to ionizing radiation].
Medicina 2001;61(5 Pt 2):655-7.
2001: James A Fagin
Mouse genetic models to explore the function of IGF-I in smooth muscle.
Medicina 2001;61(5 Pt 2):653-4.
2001: Daria Mochly-Rosen; James A Fagin; Jeffrey A Knauf; Yuri E Nikiforov; Tamar Liron; Deborah Schechtman
Spontaneous occurrence of an inhibitor of protein kinase C localization in a thyroid cancer cell line: role in thyroid tumorigenesis.
Advances in enzyme regulation 2001;41():87-97.
2000: J M Shirokawa; R Elisei; Jeffrey A Knauf; T Hara; Jianwei Wang; Harold I Saavedra; James A Fagin
Conditional apoptosis induced by oncogenic ras in thyroid cells.
Molecular endocrinology (Baltimore, Md.) 2000;14(11):1725-38.
2000: Marina N Nikiforova; James R Stringer; Ruthann I Blough; Mario Medvedovic; James A Fagin; Yuri E Nikiforov
Proximity of chromosomal loci that participate in radiation-induced rearrangements in human cells.
Science (New York, N.Y.) 2000;290(5489):138-41.
2000: Maria Luisa Martelli; Maria Giuseppina Miano; C Battaglia; Francesco Trapasso; A Stella; Rodolfo Iuliano; Roberta Visconti; James A Fagin; Massimo Santoro; Alfredo Fusco
The highly malignant phenotype of anaplastic thyroid carcinoma cell lines is recessive.
European journal of endocrinology / European Federation of Endocrine Societies 2000;143(4):515-21.
2000: Harold I Saavedra; Jeffrey A Knauf; J M Shirokawa; Jianwei Wang; Bin Ouyang; R Elisei; Peter J Stambrook; James A Fagin
The RAS oncogene induces genomic instability in thyroid PCCL3 cells via the MAPK pathway.
Oncogene 2000;19(34):3948-54.
2000: William D Stuart; S Maeda; P Khera; James A Fagin; Thomas Landes Clemens
Parathyroid hormone-related protein induces G1 phase growth arrest of vascular smooth muscle cells.
American journal of physiology. Endocrinology and metabolism 2000;279(1):E60-7.
2000: G Zhao; Marie-Claude Monier-Faugere; M Chris Langub; Zhaopo Geng; T Nakayama; J Wesley Pike; Steven D Chernausek; Clifford J Rosen; L R Donahue; Hartmut H Malluche; James A Fagin; Thomas Landes Clemens
Targeted overexpression of insulin-like growth factor I to osteoblasts of transgenic mice: increased trabecular bone volume without increased osteoblast proliferation.
Endocrinology 2000;141(7):2674-82.
1999: Yuri E Nikiforov; Amy Koshoffer; Marina N Nikiforova; J Stringer; James A Fagin
Chromosomal breakpoint positions suggest a direct role for radiation in inducing illegitimate recombination between the ELE1 and RET genes in radiation-induced thyroid carcinomas.
Oncogene 1999;18(46):6330-4.
1999: Jeffrey A Knauf; R Elisei; Daria Mochly-Rosen; Tamar Liron; Xiao-Ning Chen; R Gonsky; Julie R Korenberg; James A Fagin
Involvement of protein kinase Cepsilon (PKCepsilon) in thyroid cell death. A truncated chimeric PKCepsilon cloned from a thyroid cancer cell line protects thyroid cells from apoptosis.
The Journal of biological chemistry 1999;274(33):23414-25.
1999: Marina N Nikiforova; Yuri E Nikiforov; Paul Williams Biddinger; D R Gnepp; L A Grosembacher; B L Wajchenberg; James A Fagin; R M Cohen
Frequent loss of heterozygosity at chromosome 3p14.2-3p21 in human pancreatic islet cell tumours.
Clinical endocrinology 1999;51(1):27-33.
1999: Jin Qian; John N Lorenz; S Maeda; Roy L Sutliff; C Weber; T Nakayama; Melissa C Colbert; Richard J Paul; James A Fagin; Thomas Landes Clemens
Reduced blood pressure and increased sensitivity of the vasculature to parathyroid hormone-related protein (PTHrP) in transgenic mice overexpressing the PTH/PTHrP receptor in vascular smooth muscle.
Endocrinology 1999;140(4):1826-33.
1999: S Maeda; Roy L Sutliff; Jin Qian; John N Lorenz; J Wang; H Tang; T Nakayama; C Weber; David Witte; AR Strauch; Richard J Paul; James A Fagin; Thomas Landes Clemens
Targeted overexpression of parathyroid hormone-related protein (PTHrP) to vascular smooth muscle in transgenic mice lowers blood pressure and alters vascular contractility.
Endocrinology 1999;140(4):1815-25.
1998: P Fainstein Day; James A Fagin; R M Vaglio; Leon Litwak; M F Picasso; RA Gutman
Growth hormone-insulin-like growth factor-I axis in adult insulin-dependent diabetic patients: evidence for central hypersensitivity to growth hormone-releasing hormone and peripheral resistance to growth hormone.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1998;30(12):737-42.
1998: R Elisei; M Shiohara; H P Koeffler; James A Fagin
Genetic and epigenetic alterations of the cyclin-dependent kinase inhibitors p15INK4b and p16INK4a in human thyroid carcinoma cell lines and primary thyroid carcinomas.
Cancer 1998;83(10):2185-93.
1998: Yuri E Nikiforov; Marina N Nikiforova; James A Fagin
Prevalence of minisatellite and microsatellite instability in radiation-induced post-Chernobyl pediatric thyroid carcinomas.
Oncogene 1998;17(15):1983-8.
1998: Silvia Ines Garcia; Thomas Landes Clemens; James A Fagin; Samuel Finkielman; Carlos J Pirola
Parathyroid hormone-related protein expression in vascular smooth muscle of spontaneously hypertensive rats: evidence for lack of response to angiotensin II.
Journal of hypertension 1998;16(10):1467-74.
1998: X Chen; Jeffrey A Knauf; R Gonsky; M Wang; E H Lai; S Chissoe; James A Fagin; Julie R Korenberg
From amplification to gene in thyroid cancer: a high-resolution mapped bacterial-artificial-chromosome resource for cancer chromosome aberrations guides gene discovery after comparative genome hybridization.
American journal of human genetics 1998;63(2):625-37.
1998: T Motomura; Yuri E Nikiforov; H Namba; Kiyoto Ashizawa; Shigenobu Nagataki; S Yamashita; James A Fagin
ret rearrangements in Japanese pediatric and adult papillary thyroid cancers.
Thyroid : official journal of the American Thyroid Association 1998;8(6):485-9.
1998: J Wang; W Niu; David P Witte; Steven D Chernausek; Yuri E Nikiforov; Thomas Landes Clemens; Behrooz G Sharifi; AR Strauch; James A Fagin
Overexpression of insulin-like growth factor-binding protein-4 (IGFBP-4) in smooth muscle cells of transgenic mice through a smooth muscle alpha-actin-IGFBP-4 fusion gene induces smooth muscle hypoplasia.
Endocrinology 1998;139(5):2605-14.
1998: S Naito; S Shimizu; S Maeda; J Wang; R Paul; James A Fagin
Ets-1 is an early response gene activated by ET-1 and PDGF-BB in vascular smooth muscle cells.
The American journal of physiology 1998;274(2 Pt 1):C472-80.
1998: L S Ward; G Brenta; Mario Medvedovic; James A Fagin
Studies of allelic loss in thyroid tumors reveal major differences in chromosomal instability between papillary and follicular carcinomas.
The Journal of clinical endocrinology and metabolism 1998;83(2):525-30.
1997: D W LaFleur; J Chiang; James A Fagin; Stephen M Schwartz; Prediman K Shah; Kurt Wallner; James S Forrester; Behrooz G Sharifi
Aortic smooth muscle cells interact with tenascin-C through its fibrinogen-like domain.
The Journal of biological chemistry 1997;272(52):32798-803.
1997: R Gonsky; Jeffrey A Knauf; R Elisei; J W Wang; S Su; James A Fagin
Identification of rapid turnover transcripts overexpressed in thyroid tumors and thyroid cancer cell lines: use of a targeted differential RNA display method to select for mRNA subsets.
Nucleic acids research 1997;25(19):3823-31.
1997: J Wang; W Niu; Yuri E Nikiforov; S Naito; Steven D Chernausek; David Witte; D LeRoith; AR Strauch; James A Fagin
Targeted overexpression of IGF-I evokes distinct patterns of organ remodeling in smooth muscle cell tissue beds of transgenic mice.
The Journal of clinical investigation 1997;100(6):1425-39.
1997: Yuri E Nikiforov; Jon M Rowland; Kevin E Bove; Hector L Monforte-Munoz; James A Fagin
Distinct pattern of ret oncogene rearrangements in morphological variants of radiation-induced and sporadic thyroid papillary carcinomas in children.
Cancer research 1997;57(9):1690-4.
1997: K Yumi; James A Fagin; M Yamashita; M C Fishbein; Prediman K Shah; S Kaul; W Niu; Jan Nilsson; Bojan Cercek
Direct effects of somatostatin analog octreotide on insulin-like growth factor-I in the arterial wall.
Laboratory investigation; a journal of technical methods and pathology 1997;76(3):329-38.
1997: James A Fagin
Familial nonmedullary thyroid carcinoma--the case for genetic susceptibility.
The Journal of clinical endocrinology and metabolism 1997;82(2):342-4.
1997: Yuri E Nikiforov; James A Fagin
Risk factors for thyroid cancer.
Trends in endocrinology and metabolism: TEM 1997;8(1):20-5.
1996: T Nakayama; M Ito; Akira Ohtsuru; S Naito; M Nakashima; James A Fagin; S Yamashita; I Sekine
Expression of the Ets-1 proto-oncogene in human gastric carcinoma: correlation with tumor invasion.
The American journal of pathology 1996;149(6):1931-9.
1996: D Spambalg; N Sharifi; R Elisei; J L Gross; G Medeiros-Neto; James A Fagin
Structural studies of the thyrotropin receptor and Gs alpha in human thyroid cancers: low prevalence of mutations predicts infrequent involvement in malignant transformation.
The Journal of clinical endocrinology and metabolism 1996;81(11):3898-901.
1996: Yuri E Nikiforov; Marina N Nikiforova; Douglas R Gnepp; James A Fagin
Prevalence of mutations of ras and p53 in benign and malignant thyroid tumors from children exposed to radiation after the Chernobyl nuclear accident.
Oncogene 1996;13(4):687-93.
1996: S Maeda; S Wu; H Jüppner; J Green; A M Aragay; James A Fagin; Thomas Landes Clemens
Cell-specific signal transduction of parathyroid hormone (PTH)-related protein through stably expressed recombinant PTH/PTHrP receptors in vascular smooth muscle cells.
Endocrinology 1996;137(8):3154-62.
1996: Anna Hultgårdh-Nilsson; Bojan Cercek; J W Wang; S Naito; C Lövdahl; Behrooz G Sharifi; James S Forrester; James A Fagin
Regulated expression of the ets-1 transcription factor in vascular smooth muscle cells in vivo and in vitro.
Circulation research 1996;78(4):589-95.
1996: James A Fagin; S H Tang; K Zeki; R Di Lauro; A Fusco; Rivkah Gonsky
Reexpression of thyroid peroxidase in a derivative of an undifferentiated thyroid carcinoma cell line by introduction of wild-type p53.
Cancer research 1996;56(4):765-71.
1996: J Cerutti; Francesco Trapasso; C Battaglia; L Zhang; Maria Luisa Martelli; Roberta Visconti; Maria Teresa Berlingieri; James A Fagin; Massimo Santoro; A Fusco
Block of c-myc expression by antisense oligonucleotides inhibits proliferation of human thyroid carcinoma cell lines.
Clinical cancer research : an official journal of the American Association for Cancer Research 1996;2(1):119-26.
1996: Shlomo Melmed; S Yamashita; H Yamasaki; James A Fagin; H Namba; H Yamamoto; M Weber; S Morita; J Webster; D Prager
IGF-I receptor signalling: lessons from the somatotroph.
Recent progress in hormone research 1996;51():189-215; discussion 215-6.
1996: Yuri E Nikiforov; Douglas R Gnepp; James A Fagin
Thyroid lesions in children and adolescents after the Chernobyl disaster: implications for the study of radiation tumorigenesis.
The Journal of clinical endocrinology and metabolism 1996;81(1):9-14.
1995: Sabrina Battista; Maria Luisa Martelli; Monica Fedele; Gennaro Chiappetta; Francesco Trapasso; Gabriella De Vita; C Battaglia; Massimo Santoro; Giuseppe Viglietto; James A Fagin
A mutated p53 gene alters thyroid cell differentiation.
Oncogene 1995;11(10):2029-37.
1995: Yuri E Nikiforov; C S Heffess; A V Korzenko; James A Fagin; Douglas R Gnepp
Characteristics of follicular tumors and nonneoplastic thyroid lesions in children and adolescents exposed to radiation as a result of the Chernobyl disaster.
Cancer 1995;76(5):900-9.
1995: K Okano; Carlos J Pirola; H M Wang; James S Forrester; James A Fagin; Thomas Landes Clemens
Involvement of cell cycle and mitogen-activated pathways in induction of parathyroid hormone-related protein gene expression in rat aortic smooth muscle cells.
Endocrinology 1995;136(4):1782-9.
1995: V Herman-Bonert; James A Fagin
Molecular pathogenesis of pituitary tumours.
Baillière's clinical endocrinology and metabolism 1995;9(2):203-23.
1995: James A Fagin
Tumor suppressor genes in human thyroid neoplasms: p53 mutations are associated undifferentiated thyroid cancers.
Journal of endocrinological investigation 1995;18(2):140-2.
1994: K Zeki; D Spambalg; N Sharifi; Rivkah Gonsky; James A Fagin
Mutations of the adenomatous polyposis coli gene in sporadic thyroid neoplasms.
The Journal of clinical endocrinology and metabolism 1994;79(5):1317-21.
1994: W L Bailey; D W LaFleur; James S Forrester; James A Fagin; Behrooz G Sharifi
Stimulation of rat vascular smooth muscle cell glycosaminoglycan production by angiotensin II.
Atherosclerosis 1994;111(1):55-64.
1994: K Okano; S Wu; X Huang; Carlos J Pirola; H Juppner; Abdul B Abou-Samra; G V Segre; K Iwasaki; James A Fagin; Thomas Landes Clemens
Parathyroid hormone (PTH)/PTH-related protein (PTHrP) receptor and its messenger ribonucleic acid in rat aortic vascular smooth muscle cells and UMR osteoblast-like cells: cell-specific regulation by angiotensin-II and PTHrP.
Endocrinology 1994;135(3):1093-9.
1994: D W LaFleur; James A Fagin; James S Forrester; S A Rubin; Behrooz G Sharifi
Cloning and characterization of alternatively spliced isoforms of rat tenascin. Platelet-derived growth factor-BB markedly stimulates expression of spliced variants of tenascin mRNA in arterial smooth muscle cells.
The Journal of biological chemistry 1994;269(32):20757-63.
1994: Carlos J Pirola; H M Wang; M I Strgacich; A Kamyar; B Cercek; James S Forrester; Thomas Landes Clemens; James A Fagin
Mechanical stimuli induce vascular parathyroid hormone-related protein gene expression in vivo and in vitro.
Endocrinology 1994;134(5):2230-6.
1994: A Kamyar; Carlos J Pirola; H M Wang; Behrooz G Sharifi; S Mohan; James S Forrester; James A Fagin
Expression and insulin-like growth factor-dependent proteolysis of insulin-like growth factor-binding protein-4 are regulated by cell confluence in vascular smooth muscle cells.
Circulation research 1994;74(4):576-85.
1994: James A Fagin
Molecular genetics of human thyroid neoplasms.
Annual review of medicine 1994;45():45-52.
1993: S Wu; Carlos J Pirola; J Green; D T Yamaguchi; K Okano; H Jueppner; James S Forrester; James A Fagin; Thomas Landes Clemens
Effects of N-terminal, midregion, and C-terminal parathyroid hormone-related peptides on adenosine 3',5'-monophosphate and cytoplasmic free calcium in rat aortic smooth muscle cells and UMR-106 osteoblast-like cells.
Endocrinology 1993;133(6):2437-44.
1993: K Matsuo; S H Tang; Behrooz G Sharifi; S A Rubin; R Schreck; James A Fagin
Growth factor production by human thyroid carcinoma cells: abundant expression of a platelet-derived growth factor-B-like protein by a human papillary carcinoma cell line.
The Journal of clinical endocrinology and metabolism 1993;77(4):996-1004.
1993: K Matsuo; S H Tang; K Zeki; RA Gutman; James A Fagin
Aberrant deoxyribonucleic acid methylation in human thyroid tumors.
The Journal of clinical endocrinology and metabolism 1993;77(4):991-5.
1993: K Matsuo; E Friedman; P V Gejman; James A Fagin
The thyrotropin receptor (TSH-R) is not an oncogene for thyroid tumors: structural studies of the TSH-R and the alpha-subunit of Gs in human thyroid neoplasms.
The Journal of clinical endocrinology and metabolism 1993;76(6):1446-51.
1993: Carlos J Pirola; H M Wang; A Kamyar; S Wu; H Enomoto; Behrooz G Sharifi; James S Forrester; Thomas Landes Clemens; James A Fagin
Angiotensin II regulates parathyroid hormone-related protein expression in cultured rat aortic smooth muscle cells through transcriptional and post-transcriptional mechanisms.
The Journal of biological chemistry 1993;268(3):1987-94.
1993: James A Fagin; K Matsuo; A Karmakar; D L Chen; S H Tang; H Phillip Koeffler
High prevalence of mutations of the p53 gene in poorly differentiated human thyroid carcinomas.
The Journal of clinical investigation 1993;91(1):179-84.
1992: James A Fagin
Genetic basis of endocrine disease 3: Molecular defects in thyroid gland neoplasia.
The Journal of clinical endocrinology and metabolism 1992;75(6):1398-400.
1992: Behrooz G Sharifi; D W LaFleur; Carlos J Pirola; James S Forrester; James A Fagin
Angiotensin II regulates tenascin gene expression in vascular smooth muscle cells.
The Journal of biological chemistry 1992;267(33):23910-5.
1992: M J Khorsandi; James A Fagin; Daniel Giannella-Neto; James S Forrester; B Cercek
Regulation of insulin-like growth factor-I and its receptor in rat aorta after balloon denudation. Evidence for local bioactivity.
The Journal of clinical investigation 1992;90(5):1926-31.
1992: Daniel Giannella-Neto; A Kamyar; Behrooz G Sharifi; Carlos J Pirola; J Kupfer; Ronald G Rosenfeld; James S Forrester; James A Fagin
Platelet-derived growth factor isoforms decrease insulin-like growth factor I gene expression in rat vascular smooth muscle cells and selectively stimulate the biosynthesis of insulin-like growth factor binding protein 4.
Circulation research 1992;71(3):646-56.
1992: M Khorsandi; James A Fagin; Michael C Fishbein; James S Forrester; Bojan Cercek
Effects of hypophysectomy on vascular insulin-like growth factor-I gene expression after balloon denudation in rats.
Atherosclerosis 1992;93(1-2):115-22.
1991: K Matsuo; S H Tang; James A Fagin
Allelotype of human thyroid tumors: loss of chromosome 11q13 sequences in follicular neoplasms.
Molecular endocrinology (Baltimore, Md.) 1991;5(12):1873-9.
1991: Rivkah Gonsky; V Herman; Shlomo Melmed; James A Fagin
Transforming DNA sequences present in human prolactin-secreting pituitary tumors.
Molecular endocrinology (Baltimore, Md.) 1991;5(11):1687-95.
1991: H Namba; J L Ross; D Goodman; James A Fagin
Solitary polyclonal autonomous thyroid nodule: a rare cause of childhood hyperthyroidism.
The Journal of clinical endocrinology and metabolism 1991;72(5):1108-12.
1991: James S Forrester; Michael C Fishbein; R Helfant; James A Fagin
A paradigm for restenosis based on cell biology: clues for the development of new preventive therapies.
Journal of the American College of Cardiology 1991;17(3):758-69.
1990: V Herman; James A Fagin; Rivkah Gonsky; K Kovacs; Shlomo Melmed
Clonal origin of pituitary adenomas.
The Journal of clinical endocrinology and metabolism 1990;71(6):1427-33.
1990: H Namba; S A Rubin; James A Fagin
Point mutations of ras oncogenes are an early event in thyroid tumorigenesis.
Molecular endocrinology (Baltimore, Md.) 1990;4(10):1474-9.
1990: H Namba; RA Gutman; K Matsuo; A Alvarez; James A Fagin
H-ras protooncogene mutations in human thyroid neoplasms.
The Journal of clinical endocrinology and metabolism 1990;71(1):223-9.
1990: H Namba; K Matsuo; James A Fagin
Clonal composition of benign and malignant human thyroid tumors.
The Journal of clinical investigation 1990;86(1):120-5.
1990: Bojan Cercek; Michael C Fishbein; James S Forrester; R H Helfant; James A Fagin
Induction of insulin-like growth factor I messenger RNA in rat aorta after balloon denudation.
Circulation research 1990;66(6):1755-60.
1989: James A Fagin; C Fernandez-Mejia; Shlomo Melmed
Pituitary insulin-like growth factor-I gene expression: regulation by triiodothyronine and growth hormone.
Endocrinology 1989;125(5):2385-91.
1989: James A Fagin; Charles T Roberts; D LeRoith; A T Brown
Coordinate decrease of tissue insulinlike growth factor I posttranscriptional alternative mRNA transcripts in diabetes mellitus.
Diabetes 1989;38(4):428-34.
1988: James A Fagin; A Brown; S Melmed
Regulation of pituitary insulin-like growth factor-I messenger ribonucleic acid levels in rats harboring somatomammotropic tumors: implications for growth hormone autoregulation.
Endocrinology 1988;122(5):2204-10.
1987: James A Fagin; K Ikejiri; S R Levin
Insulinotropic effects of vanadate.
Diabetes 1987;36(12):1448-52.
1987: James A Fagin; S Pixley; S Slanina; J Ong; S Melmed
Insulin-like growth factor I gene expression in GH3 rat pituitary cells: messenger ribonucleic acid content, immunocytochemistry, and secretion.
Endocrinology 1987;120(5):2037-43.
1987: S Melmed; James A Fagin
Acromegaly update--etiology, diagnosis and management.
The Western journal of medicine 1987;146(3):328-36.
1987: James A Fagin; S Melmed
Relative increase in insulin-like growth factor I messenger ribonucleic acid levels in compensatory renal hypertrophy.
Endocrinology 1987;120(2):718-24.
1986: S Yamashita; J Ong; James A Fagin; S Melmed
Expression of the myc cellular proto-oncogene in human thyroid tissue.
The Journal of clinical endocrinology and metabolism 1986;63(5):1170-3.
1986: S Melmed; James A Fagin; M Leung
Bromocriptine inhibits incorporation of [3H]thymidine into rat pituitary tumor cells.
Brain research 1986;369(1-2):83-90.
1986: James A Fagin; Leon Litwak; S Steiner; RA Gutman
Optimizing glycemic control: can insulin dependent diabetic patients rely on their perception of blood glucose fluctuations in order to make therapeutic decisions?
Diabetes research (Edinburgh, Scotland) 1986;3(3):139-44.
1986: S Melmed; James A Fagin
Isolation and characterization of rat-mouse somatic cell hybrids secreting growth hormone and prolactin.
Experimental cell research 1986;162(2):475-85.
1985: RA Gutman; Leon Litwak; James A Fagin; L Plantalech; S Steiner
[Insulin portable pump vs. intensified conventional injections in diabetes].
Medicina 1985;45(3):225-30.
1983: James A Fagin; Leon Litwak; RA Gutman
Economic realities of home blood glucose monitoring.
Lancet 1983;2(8351):682-3.
1983: P F Day; James A Fagin; RA Gutman
Transient glucose intolerance in rats after a single injection of serum from a diabetic patient with an unusual insulin resistance.
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 1983;37(7):354-7.
1981: James A Fagin; R Friedman; P Fireman
Allergic rhinitis.
Pediatric clinics of North America 1981;28(4):797-806.
1980: James A Fagin; J Bradley; D Williams
Carbon monoxide poisoning secondary to inhaling methylene chloride.
British medical journal 1980;281(6253):1461.