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Wayne Fairbrother

Research Profile

Concepts & Ideas

Genes & Molecular Sequences

Amino Acid Sequences

Phenomena

Chemicals & Drugs

Procedures

Anatomy

Cell Line

Living Beings

Bacillus subtilis

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Publications

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Guillaume Lessene; Kym N Lowes; Rebecca M Moss; John P Parisot; Brad E Sleebs; Brian J Smith; Ian P Street; Jerry M Adams; Jonathan B Baell; Peter M Colman; Peter Czabotar; Kurt Deshayes; Wayne J Fairbrother; John A Flygare; Paul Gibbons; David C S Huang; Wilhelmus J A Kersten; Sanji Kulasegaram; Hong Yang; Kerry Zobel; Keith G Watson
Structure-guided design of a selective BCL-XL inhibitor.
Toru Okamoto; Clifford Quan; Brian J Smith; Hong Yang; Kerry Zobel; Kurt Deshayes; Wayne J Fairbrother; Anna Fedorova; David C S Huang; Peter Czabotar
Stabilizing the pro-apoptotic BimBH3 helix (BimSAHB) does not necessarily enhance affinity or biological activity.
Eugene Varfolomeev; Jiping Zha; Kurt Deshayes; Jasmin Dynek; Wayne J Fairbrother; Anna V Fedorova; Jennifer Le Couter; Elham Moradi; Kim Newton; Domagoj Vucic
Characterization of ML-IAP protein stability and physiological role in vivo.

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All Publications

2013: Guillaume Lessene; Kym N Lowes; Rebecca M Moss; John P Parisot; Brad E Sleebs; Brian J Smith; Ian P Street; Jerry M Adams; Jonathan B Baell; Peter M Colman; Peter Czabotar; Kurt Deshayes; Wayne J Fairbrother; John A Flygare; Paul Gibbons; David C S Huang; Wilhelmus J A Kersten; Sanji Kulasegaram; Hong Yang; Kerry Zobel; Keith G Watson
Structure-guided design of a selective BCL-XL inhibitor.
Nature chemical biology 2013;9(6):390-7.
2013: Toru Okamoto; Clifford Quan; Brian J Smith; Hong Yang; Kerry Zobel; Kurt Deshayes; Wayne J Fairbrother; Anna Fedorova; David C S Huang; Peter Czabotar
Stabilizing the pro-apoptotic BimBH3 helix (BimSAHB) does not necessarily enhance affinity or biological activity.
ACS chemical biology 2013;8(2):297-302.
2012: Eugene Varfolomeev; Jiping Zha; Kurt Deshayes; Jasmin Dynek; Wayne J Fairbrother; Anna V Fedorova; Jennifer Le Couter; Elham Moradi; Kim Newton; Domagoj Vucic
Characterization of ML-IAP protein stability and physiological role in vivo.
The Biochemical journal 2012;447(3):427-36.
2011: Erin C Dueber; J Michael Elliott; Kurt Deshayes; Anna V Fedorova; Anthony M Giannetti; Sarah G Hymowitz; Andreas Lingel; Brigitte Maurer; Allyn J Schoeffler; Eugene Varfolomeev; Domagoj Vucic; Heidi J A Wallweber; Ping Wu; Kerry Zobel; Wayne J Fairbrother
Antagonists induce a conformational change in cIAP1 that promotes autoubiquitination.
Science (New York, N.Y.) 2011;334(6054):376-80.
2010: Jasmin Dynek; Tatiana Goncharov; Erin C Dueber; Anna V Fedorova; Anita Izrael-Tomasevic; Lilian Phu; Elizabeth Helgason; Wayne J Fairbrother; Kurt Deshayes; Donald Kirkpatrick; Domagoj Vucic
c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling.
The EMBO journal 2010;29(24):4198-209.
2009: Andreas Lingel; Wayne J Fairbrother
NMR assignments of the human cytokine interleukin-33.
Biomolecular NMR assignments 2009;3(2):223-5.
2009: Andreas Lingel; Thomas M Weiss; Marc Niebuhr; Borlan Pan; Brent A Appleton; Christian Wiesmann; J. Fernando Bazan; Wayne J Fairbrother
Structure of IL-33 and its interaction with the ST2 and IL-1RAcP receptors--insight into heterotrimeric IL-1 signaling complexes.
Structure (London, England : 1993) 2009;17(10):1398-410.
2009: Eric Bourhis; Andreas Lingel; Qui Phung; Wayne J Fairbrother; Andrea G Cochran
Phosphorylation of a borealin dimerization domain is required for proper chromosome segregation.
Biochemistry 2009;48(29):6783-93.
2009: John W Blankenship; Eugene Varfolomeev; Tatiana Goncharov; Anna V Fedorova; Donald Kirkpatrick; Anita Izrael-Tomasevic; Lilian Phu; David Arnott; Mariam Aghajan; Kerry Zobel; J. Fernando Bazan; Wayne J Fairbrother; Kurt Deshayes; Domagoj Vucic
Ubiquitin binding modulates IAP antagonist-stimulated proteasomal degradation of c-IAP1 and c-IAP2(1).
The Biochemical journal 2009;417(1):149-60.
2008: Eugene Varfolomeev; Tatiana Goncharov; Anna V Fedorova; Jasmin Dynek; Kerry Zobel; Kurt Deshayes; Wayne J Fairbrother; Domagoj Vucic
c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor alpha (TNFalpha)-induced NF-kappaB activation.
The Journal of biological chemistry 2008;283(36):24295-9.
2008: Jasmin Dynek; Sara M Chan; Jinfeng Liu; Jiping Zha; Wayne J Fairbrother; Domagoj Vucic
Microphthalmia-associated transcription factor is a critical transcriptional regulator of melanoma inhibitor of apoptosis in melanomas.
Cancer research 2008;68(9):3124-32.
2007: Eugene Varfolomeev; John W Blankenship; Sarah M Wayson; Anna V Fedorova; Nobuhiko Kayagaki; Parie Garg; Kerry Zobel; Jasmin Dynek; Linda O Elliott; Heidi J A Wallweber; John A Flygare; Wayne J Fairbrother; Kurt Deshayes; Xiaodong Huang; Domagoj Vucic
IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis.
Cell 2007;131(4):669-81.
2007: Domagoj Vucic; Wayne J Fairbrother
The inhibitor of apoptosis proteins as therapeutic targets in cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(20):5995-6000.
2007: Saloumeh Kadkhodayan; Linda O Elliott; Grace Mausisa; Heidi Ackerly Wallweber; Kurt Deshayes; Bainian Feng; Wayne J Fairbrother
Evaluation of assay technologies for the identification of protein-Peptide interaction antagonists.
Assay and drug development technologies 2007;5(4):501-13.
2006: Christian Wiesmann; Kenneth J Katschke; JianPing Yin; Karim Y Helmy; Micah Steffek; Wayne J Fairbrother; Scott McCallum; Lizette Embuscado; Laura DeForge; Philip E Hass; Menno van Lookeren Campagne
Structure of C3b in complex with CRIg gives insights into regulation of complement activation.
Nature 2006;444(7116):217-20.
2006: Scott McCallum; J. Fernando Bazan; Mark Merchant; JianPing Yin; Borlan Pan; Frederic J de Sauvage; Wayne J Fairbrother
Structure of SAP18: a ubiquitin fold in histone deacetylase complex assembly.
Biochemistry 2006;45(39):11974-82.
2006: Eugene Varfolomeev; Sarah M Wayson; Xiaodong Huang; Wayne J Fairbrother; Domagoj Vucic
The inhibitor of apoptosis protein fusion c-IAP2.MALT1 stimulates NF-kappaB activation independently of TRAF1 AND TRAF2.
The Journal of biological chemistry 2006;281(39):29022-9.
2006: Kerry Zobel; Lan Wang; Eugene Varfolomeev; Matthew C Franklin; Linda O Elliott; Heidi J A Wallweber; David C Okawa; John A Flygare; Domagoj Vucic; Wayne J Fairbrother; Kurt Deshayes
Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs.
ACS chemical biology 2006;1(8):525-33.
2006: Conrad Yap Edosada; Clifford Quan; Christian Wiesmann; Thuy Tran; Daniel Sutherlin; Mark A Reynolds; J Michael Elliott; Helga Raab; Wayne J Fairbrother; Beni B Wolf
Selective inhibition of fibroblast activation protein protease based on dipeptide substrate specificity.
The Journal of biological chemistry 2006;281(11):7437-44.
2006: Conrad Yap Edosada; Clifford Quan; Thuy Tran; Victoria Pham; Christian Wiesmann; Wayne J Fairbrother; Beni B Wolf
Peptide substrate profiling defines fibroblast activation protein as an endopeptidase of strict Gly(2)-Pro(1)-cleaving specificity.
FEBS letters 2006;580(6):1581-6.
2005: Scott McCallum; JianPing Yin; Wayne J Fairbrother
1H, 13C, and 15N resonance assignments of SAP18.
Journal of biomolecular NMR 2005;31(3):259.
2005: Domagoj Vucic; Matthew C Franklin; Heidi J A Wallweber; Kanad Das; Brendan P Eckelman; Hwain Shin; Linda O Elliott; Saloumeh Kadkhodayan; Kurt Deshayes; Guy S Salvesen; Wayne J Fairbrother
Engineering ML-IAP to produce an extraordinarily potent caspase 9 inhibitor: implications for Smac-dependent anti-apoptotic activity of ML-IAP.
The Biochemical journal 2005;385(Pt 1):11-20.
2004: Jennifer Stamos; Charles Eigenbrot; Gerald R Nakamura; Mark E Reynolds; JianPing Yin; Henry B Lowman; Wayne J Fairbrother; Melissa A Starovasnik
Convergent recognition of the IgE binding site on the high-affinity IgE receptor.
Structure (London, England : 1993) 2004;12(7):1289-301.
2003: Matthew C Franklin; Saloumeh Kadkhodayan; Heidi Ackerly; Daniela Alexandru; Mark D Distefano; Linda O Elliott; John A Flygare; Grace Mausisa; David C Okawa; Danny Ong; Domagoj Vucic; Kurt Deshayes; Wayne J Fairbrother
Structure and function analysis of peptide antagonists of melanoma inhibitor of apoptosis (ML-IAP).
Biochemistry 2003;42(27):8223-31.
2003: Nathaniel C Gordon; Borlan Pan; Sarah G Hymowitz; JianPing Yin; Robert F Kelley; Andrea G Cochran; Minhong Yan; Xiaodong Huang; Wayne J Fairbrother; Melissa A Starovasnik
BAFF/BLyS receptor 3 comprises a minimal TNF receptor-like module that encodes a highly focused ligand-binding site.
Biochemistry 2003;42(20):5977-83.
2003: Sachdev S Sidhu; Wayne J Fairbrother; Kurt Deshayes
Exploring protein-protein interactions with phage display.
Chembiochem : a European journal of chemical biology 2003;4(1):14-25.
2002: Domagoj Vucic; Kurt Deshayes; Heidi Ackerly; Maria Teresa Pisabarro; Saloumeh Kadkhodayan; Wayne J Fairbrother; Xiaodong Huang
SMAC negatively regulates the anti-apoptotic activity of melanoma inhibitor of apoptosis (ML-IAP).
The Journal of biological chemistry 2002;277(14):12275-9.
2002: Xiaoqing Sun; Jianping Yin; Melissa A Starovasnik; Wayne J Fairbrother; Xiaodong Huang
Identification of a novel homotypic interaction motif required for the phosphorylation of receptor-interacting protein (RIP) by RIP3.
The Journal of biological chemistry 2002;277(11):9505-11.
2002: Minhong Yan; Zemin Zhang; John Ridgway Brady; Sarah Schilbach; Wayne J Fairbrother; Xiaodong Huang
Identification of a novel death domain-containing adaptor molecule for ectodysplasin-A receptor that is mutated in crinkled mice.
Current biology : CB 2002;12(5):409-13.
2002: Borlan Pan; Bing Li; Stephen J Russell; Jeffrey Tom; Andrea G Cochran; Wayne J Fairbrother
Solution structure of a phage-derived peptide antagonist in complex with vascular endothelial growth factor.
Journal of molecular biology 2002;316(3):769-87.
2001: Wayne J Fairbrother; Nathaniel C Gordon; EW Humke; Karen M O'Rourke; Melissa A Starovasnik; Jian Ping Yin; Xiaodong Huang
The PYRIN domain: a member of the death domain-fold superfamily.
Protein science : a publication of the Protein Society 2001;10(9):1911-8.
2000: EW Humke; Stephanie Shriver; Melissa A Starovasnik; Wayne J Fairbrother; Xiaodong Huang
ICEBERG: a novel inhibitor of interleukin-1beta generation.
Cell 2000;103(1):99-111.
2000: D P Meininger; M Rance; Melissa A Starovasnik; Wayne J Fairbrother; Nicholas J Skelton
Characterization of the binding interface between the E-domain of Staphylococcal protein A and an antibody Fv-fragment.
Biochemistry 2000;39(1):26-36.
1999: Melissa A Starovasnik; MP O'Connell; Wayne J Fairbrother; Robert F Kelley
Antibody variable region binding by Staphylococcal protein A: thermodynamic analysis and location of the Fv binding site on E-domain.
Protein science : a publication of the Protein Society 1999;8(7):1423-31.
1998: Christian Wiesmann; Hans W Christinger; Andrea G Cochran; BC Cunningham; Wayne J Fairbrother; C J Keenan; Gloria Meng; Abraham M de Vos
Crystal structure of the complex between VEGF and a receptor-blocking peptide.
Biochemistry 1998;37(51):17765-72.
1998: Wayne J Fairbrother; Hans W Christinger; Andrea G Cochran; Germaine Fuh; C J Keenan; Clifford Quan; Stephanie Shriver; Jeffrey Tom; James A Wells; BC Cunningham
Novel peptides selected to bind vascular endothelial growth factor target the receptor-binding site.
Biochemistry 1998;37(51):17754-64.
1998: Wayne J Fairbrother; J Liu; Paul I Pisacane; Mark X Sliwkowski; A G Palmer
Backbone dynamics of the EGF-like domain of heregulin-alpha.
Journal of molecular biology 1998;279(5):1149-61.
1998: Wayne J Fairbrother; MA Champe; Hans W Christinger; BA Keyt; Melissa A Starovasnik
Solution structure of the heparin-binding domain of vascular endothelial growth factor.
Structure (London, England : 1993) 1998;6(5):637-48.
1998: MD Ballinger; JT Jones; Julie A Lofgren; Wayne J Fairbrother; Robert W Akita; Mark X Sliwkowski; James A Wells
Selection of heregulin variants having higher affinity for the ErbB3 receptor by monovalent phage display.
The Journal of biological chemistry 1998;273(19):11675-84.
1998: JT Jones; MD Ballinger; Paul I Pisacane; Julie A Lofgren; VD Fitzpatrick; Wayne J Fairbrother; James A Wells; Mark X Sliwkowski
Binding interaction of the heregulinbeta egf domain with ErbB3 and ErbB4 receptors assessed by alanine scanning mutagenesis.
The Journal of biological chemistry 1998;273(19):11667-74.
1997: Wayne J Fairbrother; MA Champe; Hans W Christinger; BA Keyt; Melissa A Starovasnik
1H, 13C, and 15N backbone assignment and secondary structure of the receptor-binding domain of vascular endothelial growth factor.
Protein science : a publication of the Protein Society 1997;6(10):2250-60.
1997: Henry B Lowman; Wayne J Fairbrother; P H Slagle; R Kabakoff; Jun Liu; S Shire; CA Hébert
Monomeric variants of IL-8: effects of side chain substitutions and solution conditions upon dimer formation.
Protein science : a publication of the Protein Society 1997;6(3):598-608.
1997: Wayne J Fairbrother; Henry B Lowman
Molecular approaches to structure-function analysis of interleukin-8.
Methods in enzymology 1997;287():45-58.
1996: Melissa A Starovasnik; Nicholas J Skelton; MP O'Connell; Robert F Kelley; D Reilly; Wayne J Fairbrother
Solution structure of the E-domain of staphylococcal protein A.
Biochemistry 1996;35(48):15558-69.
1996: Henry B Lowman; P H Slagle; L E DeForge; C M Wirth; B L Gillece-Castro; J H Bourell; Wayne J Fairbrother
Exchanging interleukin-8 and melanoma growth-stimulating activity receptor binding specificities.
The Journal of biological chemistry 1996;271(24):14344-52.
1996: N E Jacobsen; N Abadi; Mark X Sliwkowski; D Reilly; Nicholas J Skelton; Wayne J Fairbrother
High-resolution solution structure of the EGF-like domain of heregulin-alpha.
Biochemistry 1996;35(11):3402-17.
1996: N E Jacobsen; Wayne J Fairbrother; C R Kensil; A Lim; D A Wheeler; M F Powell
Structure of the saponin adjuvant QS-21 and its base-catalyzed isomerization product by 1H and natural abundance 13C NMR spectroscopy.
Carbohydrate research 1996;280(1):1-14.
1995: B Li; J Y Tom; D Oare; R Yen; Wayne J Fairbrother; James A Wells; BC Cunningham
Minimization of a polypeptide hormone.
Science (New York, N.Y.) 1995;270(5242):1657-60.
1995: R S McDowell; K A Elias; M S Stanley; D J Burdick; J P Burnier; K S Chan; Wayne J Fairbrother; R G Hammonds; G S Ingle; N E Jacobsen; DL Mortensen; T E Rawson; W B Won; R G Clark; T C Somers
Growth hormone secretagogues: characterization, efficacy, and minimal bioactive conformation.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(24):11165-9.
1995: Joseph Hesselgesser; C E Chitnis; Louis H Miller; D G Yansura; L C Simmons; Wayne J Fairbrother; C Kotts; C Wirth; B L Gillece-Castro; Richard Horuk
A mutant of melanoma growth stimulating activity does not activate neutrophils but blocks erythrocyte invasion by malaria.
The Journal of biological chemistry 1995;270(19):11472-6.
1994: Wayne J Fairbrother; D Reilly; T J Colby; Joseph Hesselgesser; Richard Horuk
The solution structure of melanoma growth stimulating activity.
Journal of molecular biology 1994;242(3):252-70.
1994: Wayne J Fairbrother; R S McDowell; BC Cunningham
Solution conformation of an atrial natriuretic peptide variant selective for the type A receptor.
Biochemistry 1994;33(30):8897-904.
1994: James A Wells; Wayne J Fairbrother; Jacek Otlewski; M Laskowski; J Burnier
A reinvestigation of a synthetic peptide (TrPepz) designed to mimic trypsin.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(10):4110-4.
1994: D Reilly; Wayne J Fairbrother
A novel isotope labeling protocol for bacterially expressed proteins.
Journal of biomolecular NMR 1994;4(3):459-62.
1993: Wayne J Fairbrother; D Reilly; T Colby; Richard Horuk
1H assignment and secondary structure determination of human melanoma growth stimulating activity (MGSA) by NMR spectroscopy.
FEBS letters 1993;330(3):302-6.
1993: Y Chen; J Reizer; M H Saier; Wayne J Fairbrother; Peter Wright
Mapping of the binding interfaces of the proteins of the bacterial phosphotransferase system, HPr and IIAglc.
Biochemistry 1993;32(1):32-7.
1993: Y Chen; Wayne J Fairbrother; Peter Wright
Three-dimensional structures of the central regulatory proteins of the bacterial phosphotransferase system, HPr and enzyme IIAglc.
Journal of cellular biochemistry 1993;51(1):75-82.
1992: Wayne J Fairbrother; Arthur G Palmer; Mark Rance; J Reizer; M H Saier; Peter Wright
Assignment of the aliphatic 1H and 13C resonances of the Bacillus subtilis glucose permease IIA domain using double- and triple-resonance heteronuclear three-dimensional NMR spectroscopy.
Biochemistry 1992;31(18):4413-25.
1992: M J Stone; Wayne J Fairbrother; Arthur G Palmer; J Reizer; M H Saier; Peter Wright
Backbone dynamics of the Bacillus subtilis glucose permease IIA domain determined from 15N NMR relaxation measurements.
Biochemistry 1992;31(18):4394-406.
1992: Wayne J Fairbrother; G P Gippert; J Reizer; M H Saier; Peter Wright
Low resolution solution structure of the Bacillus subtilis glucose permease IIA domain derived from heteronuclear three-dimensional NMR spectroscopy.
FEBS letters 1992;296(2):148-52.
1992: Arthur G Palmer; Wayne J Fairbrother; John Cavanagh; Peter Wright; Mark Rance
Improved resolution in three-dimensional constant-time triple resonance NMR spectroscopy of proteins.
Journal of biomolecular NMR 1992;2(1):103-8.
1991: Wayne J Fairbrother; John Cavanagh; H Jane Dyson; Arthur G Palmer; S L Sutrina; J Reizer; M H Saier; Peter Wright
Polypeptide backbone resonance assignments and secondary structure of Bacillus subtilis enzyme IIIglc determined by two-dimensional and three-dimensional heteronuclear NMR spectroscopy.
Biochemistry 1991;30(28):6896-907.