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Jirí Fajkus

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Jana Fulnecková; Eunsoo Kim; B Franz Lang; Martin Lukes; Alena Lukesová; Tereza Sevcíková; Marek Eliás; Jirí Fajkus; Cestmír Vlcek; Eva Sykorová
A broad phylogenetic survey unveils the diversity and evolution of telomeres in eukaryotes.
Lenka Činčárová; Pavla Šultesová; Jirí Fajkus; Lenka Fajkusová; Hana Konečná; Gabriela Lochmanová; Kateřina Nováková; Zbynek Zdráhal
A combined approach for the study of histone deacetylase inhibitors.
Katarina Visacka; Smaranda Willcox; Michaela Wimmerova; Jirí Fajkus; Jack D Griffith; Ctirad Hofr; Ivona Necasova; Jozef Nosek; Jana Pavlouskova; Regina Sepsiova; Lucia Simonicova; Lubomir Tomaska
Synergism of the two Myb domains of Tay1 protein results in high affinity binding to telomeres.

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All Publications

2013: Jana Fulnecková; Eunsoo Kim; B Franz Lang; Martin Lukes; Alena Lukesová; Tereza Sevcíková; Marek Eliás; Jirí Fajkus; Cestmír Vlcek; Eva Sykorová
A broad phylogenetic survey unveils the diversity and evolution of telomeres in eukaryotes.
Genome biology and evolution 2013;5(3):468-83.
2012: Lenka Činčárová; Pavla Šultesová; Jirí Fajkus; Lenka Fajkusová; Hana Konečná; Gabriela Lochmanová; Kateřina Nováková; Zbynek Zdráhal
A combined approach for the study of histone deacetylase inhibitors.
Molecular bioSystems 2012;8(11):2937-45.
2012: Katarina Visacka; Smaranda Willcox; Michaela Wimmerova; Jirí Fajkus; Jack D Griffith; Ctirad Hofr; Ivona Necasova; Jozef Nosek; Jana Pavlouskova; Regina Sepsiova; Lucia Simonicova; Lubomir Tomaska
Synergism of the two Myb domains of Tay1 protein results in high affinity binding to telomeres.
The Journal of biological chemistry 2012;287(38):32206-15.
2012: Eva Polanská; Zuzana Dobšáková; Martina Dvořáčková; Jirí Fajkus; Michal Stros
HMGB1 gene knockout in mouse embryonic fibroblasts results in reduced telomerase activity and telomere dysfunction.
Chromosoma 2012;121(4):419-31.
2012: Anna Ogrocká; Eva Sýkorová; Jirí Fajkus; Miloslava Fojtová
Developmental silencing of the AtTERT gene is associated with increased H3K27me3 loading and maintenance of its euchromatic environment.
Journal of experimental botany 2012;63(11):4233-41.
2012: Eva Sýkorová; Jirí Fajkus; Miloslava Fojtová; Jana Fulnečková; Petr Mokroš; Vratislav Peška
Three TERT genes in Nicotiana tabacum.
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology 2012;20(4):381-94.
2012: Jana Fulnecková; Alena Lukešová; Jirí Fajkus; Tereza Hasíková; Marek Eliáš; Eva Sýkorová
Dynamic evolution of telomeric sequences in the green algal order Chlamydomonadales.
Genome biology and evolution 2012;4(3):248-64.
2011: Eva Majerová; Iva Mozgová; Miroslava Bittová; Miloslava Fojtová; Jirí Fajkus
Hypomethylating drugs efficiently decrease cytosine methylation in telomeric DNA and activate telomerase without affecting telomere lengths in tobacco cells.
Plant molecular biology 2011;77(4-5):371-80.
2011: Miloslava Fojtová; Iva Mozgová; Vratislav Peška; Zuzana Dobšáková; Jirí Fajkus; Eva Sýkorová
Molecular analysis of T-DNA insertion mutants identified putative regulatory elements in the AtTERT gene.
Journal of experimental botany 2011;62(15):5531-45.
2011: Jana Majerská; Eva Sýkorová; Jirí Fajkus
Non-telomeric activities of telomerase.
Molecular bioSystems 2011;7(4):1013-23.
2011: Jirí Fajkus
Proteins in signalling pathways and chromosome stability in plants.
Current protein & peptide science 2011;12(2):74.
2011: Vratislav Peška; Petra Procházková Schrumpfová; Jirí Fajkus
Using the telobox to search for plant telomere binding proteins.
Current protein & peptide science 2011;12(2):75-83.
2011: Petra Procházková Schrumpfová; Miloslava Fojtová; Petr Mokroš; Klaus D Grasser; Jirí Fajkus
Role of HMGB proteins in chromatin dynamics and telomere maintenance in Arabidopsis thaliana.
Current protein & peptide science 2011;12(2):105-11.
2010: Miloslava Fojtová; Joseph T Y Wong; Martina Dvorácková; Kosmo T H Yan; Eva Sýkorová; Jirí Fajkus
Telomere maintenance in liquid crystalline chromosomes of dinoflagellates.
Chromosoma 2010;119(5):485-93.
2010: Iva Mozgová; Petr Mokros; Jirí Fajkus
Dysfunction of chromatin assembly factor 1 induces shortening of telomeres and loss of 45S rDNA in Arabidopsis thaliana.
The Plant cell 2010;22(8):2768-80.
2010: M Chester; E Sykorova; Jirí Fajkus; Andrew R Leitch
Single integration and spread of a Copia-like sequence nested in rDNA intergenic spacers of Allium cernuum (Alliaceae).
Cytogenetic and genome research 2010;129(1-3):35-46.
2010: Radan Goldmann; Lukás Tichý; Tomás Freiberger; Petra Zapletalová; Ondrej Letocha; Vladimír Soska; Jirí Fajkus; Lenka Fajkusová
Genomic characterization of large rearrangements of the LDLR gene in Czech patients with familial hypercholesterolemia.
BMC medical genetics 2010;11():115.
2009: Eva Sýkorová; Jirí Fajkus
Structure-function relationships in telomerase genes.
Biology of the cell / under the auspices of the European Cell Biology Organization 2009;101(7):375-92, 1 p following 392.
2009: Ctirad Hofr; Pavla Sultesová; Michal Zimmermann; Iva Mozgová; Petra Procházková Schrumpfová; Michaela Wimmerova; Jirí Fajkus
Single-Myb-histone proteins from Arabidopsis thaliana: a quantitative study of telomere-binding specificity and kinetics.
The Biochemical journal 2009;419(1):221-8, 2 p following 228.
2008: Zuzana Kunická; Igor Mucha; Jirí Fajkus
Telomerase activity in head and neck cancer.
Anticancer research 2008;28(5B):3125-9.
2008: Iva Mozgová; Petra Procházková Schrumpfová; Ctirad Hofr; Jirí Fajkus
Functional characterization of domains in AtTRB1, a putative telomere-binding protein in Arabidopsis thaliana.
Phytochemistry 2008;69(9):1814-9.
2008: Petra Procházková Schrumpfová; Milan Kuchar; Jan Palecek; Jirí Fajkus
Mapping of interaction domains of putative telomere-binding proteins AtTRB1 and AtPOT1b from Arabidopsis thaliana.
FEBS letters 2008;582(10):1400-6.
2008: Eva Růcková; Jirí Friml; Petra Procházková Schrumpfová; Jirí Fajkus
Role of alternative telomere lengthening unmasked in telomerase knock-out mutant plants.
Plant molecular biology 2008;66(6):637-46.
2008: V Peska; Eva Sýkorová; Jirí Fajkus
Two faces of Solanaceae telomeres: a comparison between Nicotiana and Cestrum telomeres and telomere-binding proteins.
Cytogenetic and genome research 2008;122(3-4):380-7.
2008: Jirí Fajkus; Martina Dvorácková; Eva Sýkorová
Analysis of telomeres and telomerase.
Methods in molecular biology (Clifton, N.J.) 2008;463():267-96.
2007: Gabriela Rotková; Eva Sýkorová; Jirí Fajkus
Characterization of nucleoprotein complexes in plants with human-type telomere motifs.
Plant physiology and biochemistry : PPB / Société française de physiologie végétale 2007;45(9):716-21.
2007: Eva Zapletalová; Petra Hedvicáková; Libor Kozák; Petr Vondrácek; Renata Gaillyová; Tat'ána Maríková; Zdenek Kalina; Vera Jüttnerová; Jirí Fajkus; Lenka Fajkusová
Analysis of point mutations in the SMN1 gene in SMA patients bearing a single SMN1 copy.
Neuromuscular disorders : NMD 2007;17(6):476-81.
2007: Kristýna Stehlíková; Eva Zapletalová; Jana Sedlácková; Markéta Hermanová; Petr Vondrácek; Tat'ána Maríková; Radim Mazanec; Josef Zámecník; Stanislav Vohánka; Jirí Fajkus; Lenka Fajkusová
Quantitative analysis of CAPN3 transcripts in LGMD2A patients: involvement of nonsense-mediated mRNA decay.
Neuromuscular disorders : NMD 2007;17(2):143-7.
2006: Jirí Fajkus
Detection of telomerase activity by the TRAP assay and its variants and alternatives.
Clinica chimica acta; international journal of clinical chemistry 2006;371(1-2):25-31.
2006: Eva Sykorová; Jirí Fajkus; Marie Mezníková; Kar Yoong Lim; Kamila Neplechová; Frank R Blattner; Mark W Chase; Andrew R Leitch
Minisatellite telomeres occur in the family Alliaceae but are lost in Allium.
American journal of botany 2006;93(6):814-23.
2006: Eva Sýkorová; Andrew R Leitch; Jirí Fajkus
Asparagales telomerases which synthesize the human type of telomeres.
Plant molecular biology 2006;60(5):633-46.
2005: Kamila Neplechová; Eva Sýkorová; Jirí Fajkus
Comparison of different kinds of probes used for analysis of variant telomeric sequences.
Biophysical chemistry 2005;117(3):225-31.
2005: Jirí Fajkus; Eva Sýkorová; Andrew R Leitch
Techniques in plant telomere biology.
BioTechniques 2005;38(2):233-43.
2005: Jirí Fajkus; Eva Sýkorová; Andrew R Leitch
Telomeres in evolution and evolution of telomeres.
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology 2005;13(5):469-79.
2004: Milan Kuchar; Jirí Fajkus
Interactions of putative telomere-binding proteins in Arabidopsis thaliana: identification of functional TRF2 homolog in plants.
FEBS letters 2004;578(3):311-5.
2004: Petra Schrumpfová; Milan Kuchar; Gabriela Miková; Lenka Skrísovská; Tatiana Kubicárová; Jirí Fajkus
Characterization of two Arabidopsis thaliana myb-like proteins showing affinity to telomeric DNA sequence.
Genome / National Research Council Canada = Génome / Conseil national de recherches Canada 2004;47(2):316-24.
2004: G Rotková; M Sklenicková; M Dvorácková; Eva Sýkorová; E Sýrová; Andrew R Leitch; Jirí Fajkus
An evolutionary change in telomere sequence motif within the plant section Asparagales had significance for telomere nucleoprotein complexes.
Cytogenetic and genome research 2004;107(1-2):132-8.
2004: Jan Malaska; Zuzana Kunická; M Borský; M Sklenicková; M Novotná; Lenka Fajkusová; Jan Zaloudík; Jirí Fajkus
Telomerase as a diagnostic and predictive marker in colorectal carcinoma.
Neoplasma 2004;51(2):90-6.
2003: Eva Sýkorová; K Yoong Lim; Jirí Fajkus; Andrew R Leitch
The signature of the Cestrum genome suggests an evolutionary response to the loss of (TTTAGGG)n telomeres.
Chromosoma 2003;112(4):164-72.
2003: Jirí Fajkus; Kvĕta Koppová; Zuzana Kunická
Dual-color real-time telomeric repeat amplification protocol.
BioTechniques 2003;35(5):912-4.
2003: Eva Sýkorová; K Yoong Lim; Zuzana Kunická; Mark W Chase; Michael D Bennett; Jirí Fajkus; Andrew R Leitch
Telomere variability in the monocotyledonous plant order Asparagales.
Proceedings. Biological sciences / The Royal Society 2003;270(1527):1893-904.
2003: M Sklenicková; Jirí Fajkus
[Telomere analysis in tumor cells using in situ techniques].
Casopís lékar̆ů c̆eských 2003;142(8):479-82.
2003: Eva Sykorova; K Yoong Lim; Mark W Chase; Sandra Knapp; Ilia Leitch; Andrew R Leitch; Jirí Fajkus
The absence of Arabidopsis-type telomeres in Cestrum and closely related genera Vestia and Sessea (Solanaceae): first evidence from eudicots.
The Plant journal : for cell and molecular biology 2003;34(3):283-91.
2003: Eva Sýkorová; J Cartagena; M Horáková; K Fukui; Jirí Fajkus
Characterization of telomere-subtelomere junctions in Silene latifolia.
Molecular genetics and genomics : MGG 2003;269(1):13-20.
2003: Jirí Fajkus; Marek Borsky; Zuzana Kunická; Martina Kovaríková; Dana Dvoráková; Jirina Hofmanová; Alois Kozubík
Changes in telomerase activity, expression and splicing in response to differentiation of normal and carcinoma colon cells.
Anticancer research 2003;23(2B):1605-12.
2002: Miloslava Fojtová; Jana Fulnecková; Jirí Fajkus; Ales Kovarík
Recovery of tobacco cells from cadmium stress is accompanied by DNA repair and increased telomerase activity.
Journal of experimental botany 2002;53(378):2151-8.
2002: Jirí Fajkus; M Simícková; Jan Malaska
Tiptoeing to chromosome tips: facts, promises and perils of today's human telomere biology.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2002;357(1420):545-62.
2001: Lenka Fajkusová; Zdenek Lukás; M Tvrdíková; Viera Kuhrová; J Hájek; Jirí Fajkus
Novel dystrophin mutations revealed by analysis of dystrophin mRNA: alternative splicing suppresses the phenotypic effect of a nonsense mutation.
Neuromuscular disorders : NMD 2001;11(2):133-8.
2001: Jirí Fajkus; E N Trifonov
Columnar packing of telomeric nucleosomes.
Biochemical and biophysical research communications 2001;280(4):961-3.
2001: Eva Sýkorová; Jirí Fajkus; M Ito; K Fukui
Transition between two forms of heterochromatin at plant subtelomeres.
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology 2001;9(4):309-23.
2000: Jan Malaska; M Sklenicková; K Krejcí; Lenka Fajkusová; M Bajer; Hana Hrstková; Jirí Fajkus
Telomerase activity and expression and telomere analysis in situ in the course of treatment of childhood leukemias.
Blood cells, molecules & diseases 2000;26(5):534-9.
2000: Karel Riha; Thomas D McKnight; Jirí Fajkus; Boris Vyskot; Dorothy E Shippen
Analysis of the G-overhang structures on plant telomeres: evidence for two distinct telomere architectures.
The Plant journal : for cell and molecular biology 2000;23(5):633-41.
2000: Lenka Fajkusová; Jirí Fajkus; K Polácková; J Fulnecek; Dana Dvoráková; E Krahulcová
Detailed mapping of methylcytosine positions at the CpG island surrounding the Pa promoter at the bcr-abl locus in CML patients and in two cell lines, K562 and BV173.
Blood cells, molecules & diseases 2000;26(3):193-204.
2000: M Horáková; Jirí Fajkus
TAS49--a dispersed repetitive sequence isolated from subtelomeric regions of Nicotiana tomentosiformis chromosomes.
Genome / National Research Council Canada = Génome / Conseil national de recherches Canada 2000;43(2):273-84.
2000: Jana Fulnecková; Jirí Fajkus
Inhibition of plant telomerase by telomere-binding proteins from nuclei of telomerase-negative tissues.
FEBS letters 2000;467(2-3):305-10.
1998: Jirí Fajkus; Jana Fulnecková; M Hulánová; K Berková; K Ríha; Roman Matyásek
Plant cells express telomerase activity upon transfer to callus culture, without extensively changing telomere lengths.
Molecular & general genetics : MGG 1998;260(5):470-4.
1998: Karel Riha; Jirí Fajkus; Jiri Siroky; Boris Vyskot
Developmental control of telomere lengths and telomerase activity in plants.
The Plant cell 1998;10(10):1691-8.
1998: Lenka Fajkusová; V Pekarík; J Hájek; Viera Kuhrová; M Blazková; Jirí Fajkus
Characterization of two nonsense mutations in the human dystrophin gene.
Journal of neurogenetics 1998;12(3):183-9.
1997: Roman Matyásek; B Gazdová; Jirí Fajkus; M Bezdek
NTRS, a new family of highly repetitive DNAs specific for the T1 chromosome of tobacco.
Chromosoma 1997;106(6):369-79.
1997: B Koukalová; Ales Kovarík; Jirí Fajkus; J Siroký
Chromatin fragmentation associated with apoptotic changes in tobacco cells exposed to cold stress.
FEBS letters 1997;414(2):289-92.
1997: Lenka Fajkusová; Viera Kuhrová; J Hájek; Jirí Fajkus
[Detection of extensive deletions and duplications in the dystrophin gene].
Casopís lékar̆ů c̆eských 1997;136(5):148-50.
1997: Lenka Fajkusová; V Kuhrovà; J Hájek; Jirí Fajkus
Distribution of dystrophin gene deletions mapped by multiplex PCR in the Moravian population.
Molecular and cellular probes 1997;11(1):85-7.
1996: Jirí Fajkus; Ales Kovarík; R Královics
Telomerase activity in plant cells.
FEBS letters 1996;391(3):307-9.
1996: Roman Matyásek; Jaroslav Fulnecek; Jirí Fajkus; M Bezdĕk
Evidence for a sequence-directed conformation periodicity in the genomic highly repetitive DNA detectable with single-strand-specific chemical probe potassium permanganate.
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology 1996;4(5):340-9.
1995: Jirí Fajkus; Ales Kovarík; R Královics; M Bezdĕk
Organization of telomeric and subtelomeric chromatin in the higher plant Nicotiana tabacum.
Molecular & general genetics : MGG 1995;247(5):633-8.
1995: B Gazdová; J Siroký; Jirí Fajkus; Bretislav Brzobohatý; A Kenton; A Parokonny; Pat (JS) Heslop-Harrison; Klaus Palme; M Bezdĕk
Characterization of a new family of tobacco highly repetitive DNA, GRS, specific for the Nicotiana tomentosiformis genomic component.
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology 1995;3(4):245-54.
1995: Jirí Fajkus; R Královics; Ales Kovarík; Lenka Fajkusová
The telomeric sequence is directly attached to the HRS60 subtelomeric tandem repeat in tobacco chromosomes.
FEBS letters 1995;364(1):33-5.
1995: R Kralovics; Jirí Fajkus; Ales Kovarík; M Bezdĕk
DNA curvature of the tobacco GRS repetitive sequence family and its relation to nucleosome positioning.
Journal of biomolecular structure & dynamics 1995;12(5):1103-19.
1992: Jirí Fajkus; Boris Vyskot; M Bezdĕk
Changes in chromatin structure due to hypomethylation induced with 5-azacytidine or DL-ethionine.
FEBS letters 1992;314(1):13-6.
1992: Jirí Fajkus; J Reich
Stable DNA-polypeptide complexes from eukaryotic nuclei purified on heparin Sepharose.
Folia biologica 1992;38(5):307-15.
1991: Jirí Fajkus; J Reich
Evaluation of restriction endonuclease cleavage of plant nuclear DNA using contaminating chloroplast DNA.
Folia biologica 1991;37(3-4):224-6.