John Falck

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Kunert Mary Pat; Friesma Jill; Falck John R; Lombard Julian H
CYP450 4A inhibition attenuates O2 induced arteriolar constriction in chronic but not acute Goldblatt hypertension.
Chawengsub Yuttana; Gauthier Kathryn M; Nithipatikom Kasem; Hammock Bruce D; Falck John R; Narsimhaswamy Dubasi; Campbell William B
Identification of 13-hydroxy-14,15-epoxyeicosatrienoic acid as an acid-stable endothelium-derived hyperpolarizing factor in rabbit arteries.
Falck J R; Bandyopadhyay Anish; Puli Narender; Kundu Abhijit; Reddy L Manmohan; Barma Deb K; He Anyu; Zhang Hongming; Kashinath Dhurke; Baati Rachid
Cascade synthesis of (E)-2-alkylidenecyclobutanols.

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All Publications

2009: Kunert Mary Pat; Friesma Jill; Falck John R; Lombard Julian H
CYP450 4A inhibition attenuates O2 induced arteriolar constriction in chronic but not acute Goldblatt hypertension.
Microvascular research 2009;78(3):442-6.
2009: Chawengsub Yuttana; Gauthier Kathryn M; Nithipatikom Kasem; Hammock Bruce D; Falck John R; Narsimhaswamy Dubasi; Campbell William B
Identification of 13-hydroxy-14,15-epoxyeicosatrienoic acid as an acid-stable endothelium-derived hyperpolarizing factor in rabbit arteries.
The Journal of biological chemistry 2009;284(45):31280-90.
2009: Falck J R; Bandyopadhyay Anish; Puli Narender; Kundu Abhijit; Reddy L Manmohan; Barma Deb K; He Anyu; Zhang Hongming; Kashinath Dhurke; Baati Rachid
Cascade synthesis of (E)-2-alkylidenecyclobutanols.
Organic letters 2009;11(20):4764-6.
2009: Inoue Kazuyoshi; Sodhi Komal; Puri Nitin; Gotlinger Katherine H; Cao Jiang; Rezzani Rita; Falck John R; Abraham Nader G; Laniado-Schwartzman Michal
Endothelial-specific CYP4A2 overexpression leads to renal injury and hypertension via increased production of 20-HETE.
American journal of physiology. Renal physiology 2009;297(4):F875-84.
2009: Akbulut Talha; Regner Kevin R; Roman Richard J; Avner Ellis D; Falck John R; Park Frank
20-HETE activates the Raf/MEK/ERK pathway in renal epithelial cells through an EGFR- and c-Src-dependent mechanism.
American journal of physiology. Renal physiology 2009;297(3):F662-70.
2009: Gross Garrett J; Gauthier Kathryn M; Moore Jeannine; Campbell William B; Falck John R; Nithipatikom Kasem
Evidence for role of epoxyeicosatrienoic acids in mediating ischemic preconditioning and postconditioning in dog.
American journal of physiology. Heart and circulatory physiology 2009;297(1):H47-52.
2009: Chaudhary Ketul R; Batchu Sri Nagarjun; Das Dipankar; Suresh Mavanur R; Falck John R; Graves Joan P; Zeldin Darryl C; Seubert John M
Role of B-type natriuretic peptide in epoxyeicosatrienoic acid-mediated improved post-ischaemic recovery of heart contractile function.
Cardiovascular research 2009;83(2):362-70.
2009: Sharma Mukut; McCarthy Ellen T; Reddy D Sudarshan; Patel Paresh K; Savin Virginia J; Medhora Meetha; Falck John R
8,9-Epoxyeicosatrienoic acid protects the glomerular filtration barrier.
Prostaglandins & other lipid mediators 2009;89(1-2):43-51.
2009: Bodiga Sreedhar; Zhang Rong; Jacobs Dexter E; Larsen Brandon T; Tampo Akihito; Manthati Vijay L; Kwok Wai-Meng; Zeldin Darryl C; Falck John R; Gutterman David D; Jacobs Elizabeth R; Medhora Meetha M
Protective actions of epoxyeicosatrienoic acid: dual targeting of cardiovascular PI3K and KATP channels.
Journal of molecular and cellular cardiology 2009;46(6):978-88.
2009: Katragadda D; Batchu S N; Cho W J; Chaudhary K R; Falck J R; Seubert J M
Epoxyeicosatrienoic acids limit damage to mitochondrial function following stress in cardiac cells.
Journal of molecular and cellular cardiology 2009;46(6):867-75.
2009: Kashinath Dhurke; Mioskowski Charles; Falck J R; Goli Mohan; Meunier Stéphane; Baati Rachid; Wagner Alain
Highly stereoselective synthesis of (Z,E)-1-halo-1,3-dienol esters via rearrangement of Fischer chromium chloro-carbenes using microwave irradiation.
Organic & biomolecular chemistry 2009;7(9):1771-4.
2009: Wang Jingli; Schmidt James R; Roman Richard J; Anjaiah Siddam; Falck John R; Lombard Julian H
Modulation of vascular O2 responses by cytochrome 450-4A omega-hydroxylase metabolites in Dahl salt-sensitive rats.
Microcirculation (New York, N.Y. : 1994) 2009;16(4):345-54.
2009: Dhanasekaran Anuradha; Bodiga Sreedhar; Gruenloh Stephanie; Gao Ying; Dunn Laurel; Falck John R; Buonaccorsi J Noelle; Medhora Meetha; Jacobs Elizabeth R
20-HETE increases survival and decreases apoptosis in pulmonary arteries and pulmonary artery endothelial cells.
American journal of physiology. Heart and circulatory physiology 2009;296(3):H777-86.
2009: Regner Kevin R; Zuk Anna; Van Why Scott K; Shames Brian D; Ryan Robert P; Falck John R; Manthati Vijay L; McMullen Meghan E; Ledbetter Steven R; Roman Richard J
Protective effect of 20-HETE analogues in experimental renal ischemia reperfusion injury.
Kidney international 2009;75(5):511-7.
2008: Rodella Luigi F; Vanella Luca; Peterson Stephen J; Drummond George; Rezzani Rita; Falck John R; Abraham Nader G
Heme oxygenase-derived carbon monoxide restores vascular function in type 1 diabetes.
Drug metabolism letters 2008;2(4):290-300.
2008: Liclican Elvira L; McGiff John C; Falck John R; Carroll Mairéad A
Failure to upregulate the adenosine2A receptor-epoxyeicosatrienoic acid pathway contributes to the development of hypertension in Dahl salt-sensitive rats.
American journal of physiology. Renal physiology 2008;295(6):F1696-704.
2008: Keserü Benjamin; Barbosa-Sicard Eduardo; Popp Rüdiger; Fisslthaler Beate; Dietrich Alexander; Gudermann Thomas; Hammock Bruce D; Falck John R; Weissmann Norbert; Busse Rudi; Fleming Ingrid
Epoxyeicosatrienoic acids and the soluble epoxide hydrolase are determinants of pulmonary artery pressure and the acute hypoxic pulmonary vasoconstrictor response.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(12):4306-15.
2008: Nayeem Mohammed A; Poloyac Samuel M; Falck John R; Zeldin Darryl C; Ledent Catherine; Ponnoth Dovenia S; Ansari Habib R; Mustafa S Jamal
Role of CYP epoxygenases in A2A AR-mediated relaxation using A2A AR-null and wild-type mice.
American journal of physiology. Heart and circulatory physiology 2008;295(5):H2068-78.
2008: Park Yoonjung; Capobianco Stefano; Gao Xue; Falck John R; Dellsperger Kevin C; Zhang Cuihua
Role of EDHF in type 2 diabetes-induced endothelial dysfunction.
American journal of physiology. Heart and circulatory physiology 2008;295(5):H1982-8.
2008: Webler Anke C; Michaelis U Ruth; Popp Rüdiger; Barbosa-Sicard Eduardo; Murugan Andiappan; Falck John R; Fisslthaler Beate; Fleming Ingrid
Epoxyeicosatrienoic acids are part of the VEGF-activated signaling cascade leading to angiogenesis.
American journal of physiology. Cell physiology 2008;295(5):C1292-301.
2008: Guo Austin M; Sheng Ju; Scicli Gloria M; Arbab Ali S; Lehman Norman L; Edwards Paul A; Falck John R; Roman Richard J; Scicli A Guillermo
Expression of CYP4A1 in U251 human glioma cell induces hyperproliferative phenotype in vitro and rapidly growing tumors in vivo.
The Journal of pharmacology and experimental therapeutics 2008;327(1):10-9.
2008: Chen Jian-Kang; Chen Jianchun; Imig John D; Wei Shouzuo; Hachey David L; Guthi Jagadeesh Setti; Falck John R; Capdevila Jorge H; Harris Raymond C
Identification of novel endogenous cytochrome p450 arachidonate metabolites with high affinity for cannabinoid receptors.
The Journal of biological chemistry 2008;283(36):24514-24.
2008: Rasko David A; Moreira Cristiano G; Li De Run; Reading Nicola C; Ritchie Jennifer M; Waldor Matthew K; Williams Noelle; Taussig Ron; Wei Shuguang; Roth Michael; Hughes David T; Huntley Jason F; Fina Maggy W; Falck John R; Sperandio Vanessa
Targeting QseC signaling and virulence for antibiotic development.
Science (New York, N.Y.) 2008;321(5892):1078-80.
2008: Liu Xiaoguang; Li Chunyuan; Falck John R; Roman Richard J; Harder David R; Koehler Raymond C
Interaction of nitric oxide, 20-HETE, and EETs during functional hyperemia in whisker barrel cortex.
American journal of physiology. Heart and circulatory physiology 2008;295(2):H619-31.
2008: Terashvili Maia; Tseng Leon F; Wu Hsiang-En; Narayanan Jayashree; Hart Lucas M; Falck John R; Pratt Phillip F; Harder David R
Antinociception produced by 14,15-epoxyeicosatrienoic acid is mediated by the activation of beta-endorphin and met-enkephalin in the rat ventrolateral periaqueductal gray.
The Journal of pharmacology and experimental therapeutics 2008;326(2):614-22.
2008: Jain Kavita; Siddam Anjaiah; Marathi Archana; Roy Uzzal; Falck J R; Balazy Michael
The mechanism of oleic acid nitration by *NO(2).
Free radical biology & medicine 2008;45(3):269-83.
2008: Jiang Houli; Zhu Angela G; Mamczur Magdalena; Morisseau Christophe; Hammock Bruce D; Falck John R; McGiff John C
Hydrolysis of cis- and trans-epoxyeicosatrienoic acids by rat red blood cells.
The Journal of pharmacology and experimental therapeutics 2008;326(1):330-7.
2008: Gross Garrett J; Gauthier Kathryn M; Moore Jeannine; Falck John R; Hammock Bruce D; Campbell William B; Nithipatikom Kasem
Effects of the selective EET antagonist, 14,15-EEZE, on cardioprotection produced by exogenous or endogenous EETs in the canine heart.
American journal of physiology. Heart and circulatory physiology 2008;294(6):H2838-44.
2008: Berezan Dellice J; Xu Yi; Falck John R; Kundu Asish P; Davidge Sandra T
Ovariectomy, but not estrogen deficiency, increases CYP4A modulation of alpha(1)-adrenergic vasoconstriction in aging female rats.
American journal of hypertension 2008;21(6):685-90.
2008: Wang ZhiJian; Wei Yuan; Falck John R; Atcha Krishnam Raju; Wang Wen-Hui
Arachidonic acid inhibits basolateral K channels in the cortical collecting duct via cytochrome P-450 epoxygenase-dependent metabolic pathways.
American journal of physiology. Renal physiology 2008;294(6):F1441-7.
2008: Medhora Meetha; Chen Yuenmu; Gruenloh Stephanie; Harland Daniel; Bodiga Sreedhar; Zielonka Jacek; Gebremedhin Debebe; Gao Ying; Falck John R; Anjaiah Siddam; Jacobs Elizabeth R
20-HETE increases superoxide production and activates NAPDH oxidase in pulmonary artery endothelial cells.
American journal of physiology. Lung cellular and molecular physiology 2008;294(5):L902-11.
2008: Cui Lijie; Isbell Marilyn A; Chawengsub Yuttana; Falck John R; Campbell William B; Nithipatikom Kasem
Structural characterization of monohydroxyeicosatetraenoic acids and dihydroxy- and trihydroxyeicosatrienoic acids by ESI-FTICR.
Journal of the American Society for Mass Spectrometry 2008;19(4):569-85.
2008: Berezan Dellice J; Dunn Kathryn M J; Falck John R; Davidge Sandra T
Aging increases cytochrome P450 4A modulation of alpha1-adrenergic vasoconstriction in mesenteric arteries.
Journal of cardiovascular pharmacology 2008;51(3):327-30.
2008: Michaelis U Ruth; Xia Ning; Barbosa-Sicard Eduardo; Falck John R; Fleming Ingrid
Role of cytochrome P450 2C epoxygenases in hypoxia-induced cell migration and angiogenesis in retinal endothelial cells.
Investigative ophthalmology & visual science 2008;49(3):1242-7.
2008: Falck J R; Gao Shuanhu; Prasad Ravi Naga; Koduru Sreenivasulu Reddy
Electrophilic alpha-thiocyanation of chiral and achiral N-acyl imides. A convenient route to 5-substituted and 5,5-disubstituted 2,4-thiazolidinediones.
Bioorganic & medicinal chemistry letters 2008;18(6):1768-71.
2008: Gauthier Kathryn M; Chawengsub Yuttana; Goldman Daniel H; Conrow Raymond E; Anjaiah Siddam; Falck J R; Campbell William B
11(R),12(S),15(S)-trihydroxyeicosa-5(Z),8(Z),13(E)-trienoic acid: an endothelium-derived 15-lipoxygenase metabolite that relaxes rabbit aorta.
American journal of physiology. Heart and circulatory physiology 2008;294(3):H1467-72.
2008: Chawengsub Yuttana; Aggarwal Nitin T; Nithipatikom Kasem; Gauthier Kathryn M; Anjaiah Siddam; Hammock Bruce D; Falck John R; Campbell William B
Identification of 15-hydroxy-11,12-epoxyeicosatrienoic acid as a vasoactive 15-lipoxygenase metabolite in rabbit aorta.
American journal of physiology. Heart and circulatory physiology 2008;294(3):H1348-56.
2008: Yang Wenqi; Tuniki Venugopal Raju; Anjaiah Siddam; Falck J R; Hillard Cecilia J; Campbell William B
Characterization of epoxyeicosatrienoic acid binding site in U937 membranes using a novel radiolabeled agonist, 20-125i-14,15-epoxyeicosa-8(Z)-enoic acid.
The Journal of pharmacology and experimental therapeutics 2008;324(3):1019-27.
2008: Imig John D; Dimitropoulou Christiana; Reddy D Sudarshan; White Richard E; Falck John R
Afferent arteriolar dilation to 11, 12-EET analogs involves PP2A activity and Ca2+-activated K+ Channels.
Microcirculation (New York, N.Y. : 1994) 2008;15(2):137-50.
2008: Cheng Jennifer; Ou Jing-Song; Singh Harpreet; Falck John R; Narsimhaswamy Dubasi; Pritchard Kirkwood A; Schwartzman Michal Laniado
20-hydroxyeicosatetraenoic acid causes endothelial dysfunction via eNOS uncoupling.
American journal of physiology. Heart and circulatory physiology 2008;294(2):H1018-26.
2008: Dhanasekaran Anuradha; Gruenloh Stephanie K; Buonaccorsi J Noelle; Zhang Rong; Gross Garrett J; Falck John R; Patel Paresh K; Jacobs Elizabeth R; Medhora Meetha
Multiple antiapoptotic targets of the PI3K/Akt survival pathway are activated by epoxyeicosatrienoic acids to protect cardiomyocytes from hypoxia/anoxia.
American journal of physiology. Heart and circulatory physiology 2008;294(2):H724-35.
2008: Li De Run; Murugan Andiappan; Falck J R
Enantioselective, organocatalytic oxy-michael addition to gamma/delta-hydroxy-alpha,beta-enones: boronate-amine complexes as chiral hydroxide synthons.
Journal of the American Chemical Society 2008;130(1):46-8.
2008: Larsen Brandon T; Gutterman David D; Sato Atsushi; Toyama Kazuyoshi; Campbell William B; Zeldin Darryl C; Manthati Vijay L; Falck John R; Miura Hiroto
Hydrogen peroxide inhibits cytochrome p450 epoxygenases: interaction between two endothelium-derived hyperpolarizing factors.
Circulation research 2008;102(1):59-67.
2008: Ishizuka Tsuneo; Cheng Jennifer; Singh Harpreet; Vitto Marco D; Manthati Vijay L; Falck John R; Laniado-Schwartzman Michal
20-Hydroxyeicosatetraenoic acid stimulates nuclear factor-kappaB activation and the production of inflammatory cytokines in human endothelial cells.
The Journal of pharmacology and experimental therapeutics 2008;324(1):103-10.
2008: Shi Yanrong; Liu Xiaoguang; Gebremedhin Debebe; Falck John R; Harder David R; Koehler Raymond C
Interaction of mechanisms involving epoxyeicosatrienoic acids, adenosine receptors, and metabotropic glutamate receptors in neurovascular coupling in rat whisker barrel cortex.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2008;28(1):111-25.
2008: Lu Biao; Falck John R
Efficient iridium-catalyzed C-H functionalization/silylation of heteroarenes.
Angewandte Chemie (International ed. in English) 2008;47(39):7508-10.
2008: He Anyu; Falck John R
Synthesis of enantioenriched alpha-(hydroxyalkyl)-tri-n-butylstannanes.
Angewandte Chemie (International ed. in English) 2008;47(35):6586-9.
2008: Li Jing; Carroll Mairead A; Chander Praveen N; Falck John R; Sangras Bhavani; Stier Charles T
Soluble epoxide hydrolase inhibitor, AUDA, prevents early salt-sensitive hypertension.
Frontiers in bioscience : a journal and virtual library 2008;13():3480-7.
2007: Illies Christopher; Gromada Jesper; Fiume Roberta; Leibiger Barbara; Yu Jia; Juhl Kirstine; Yang Shao-Nian; Barma Deb K; Falck John R; Saiardi Adolfo; Barker Christopher J; Berggren Per-Olof
Requirement of inositol pyrophosphates for full exocytotic capacity in pancreatic beta cells.
Science (New York, N.Y.) 2007;318(5854):1299-302.
2007: Hillard Cecilia J; Shi Leyu; Tuniki Venugopal Raju; Falck John R; Campbell William B
Studies of anandamide accumulation inhibitors in cerebellar granule neurons: comparison to inhibition of fatty acid amide hydrolase.
Journal of molecular neuroscience : MN 2007;33(1):18-24.
2007: Capdevila J H; Falck J R; Imig J D
Roles of the cytochrome P450 arachidonic acid monooxygenases in the control of systemic blood pressure and experimental hypertension.
Kidney international 2007;72(6):683-9.
2007: Endsley Michael P; Aggarwal Nitin; Isbell Marilyn A; Wheelock Craig E; Hammock Bruce D; Falck John R; Campbell William B; Nithipatikom Kasem
Diverse roles of 2-arachidonoylglycerol in invasion of prostate carcinoma cells: Location, hydrolysis and 12-lipoxygenase metabolism.
International journal of cancer. Journal international du cancer 2007;121(5):984-91.
2007: Jiang H; Zhu A G; Mamczur M; Falck J R; Lerea K M; McGiff J C
Stimulation of rat erythrocyte P2X7 receptor induces the release of epoxyeicosatrienoic acids.
British journal of pharmacology 2007;151(7):1033-40.
2007: Williams Jan Michael; Sharma Mukut; Anjaiahh Siddam; Falck John R; Roman Richard J
Role of endogenous CYP450 metabolites of arachidonic acid in maintaining the glomerular protein permeability barrier.
American journal of physiology. Renal physiology 2007;293(2):F501-5.
2007: Zhang David X; Gauthier Kathryn M; Falck John R; Siddam Anjaiah; Campbell William B
Steroid-producing cells regulate arterial tone of adrenal cortical arteries.
Endocrinology 2007;148(8):3569-76.
2007: Huang Hui; Morisseau Christophe; Wang JingFeng; Yang Tianxin; Falck John R; Hammock Bruce D; Wang Mong-Heng
Increasing or stabilizing renal epoxyeicosatrienoic acid production attenuates abnormal renal function and hypertension in obese rats.
American journal of physiology. Renal physiology 2007;293(1):F342-9.
2007: Ng Valerie Y; Huang Yong; Reddy L Manmohan; Falck John R; Lin Emil T; Kroetz Deanna L
Cytochrome P450 eicosanoids are activators of peroxisome proliferator-activated receptor alpha.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(7):1126-34.
2007: Pozzi Ambra; Ibanez Maria Raquel; Gatica Arnaldo E; Yang Shilin; Wei Shouzuo; Mei Shaojun; Falck John R; Capdevila Jorge H
Peroxisomal proliferator-activated receptor-alpha-dependent inhibition of endothelial cell proliferation and tumorigenesis.
The Journal of biological chemistry 2007;282(24):17685-95.
2007: Yang Wenqi; Holmes Blythe B; Gopal V Raj; Kishore R V Krishna; Sangras Bhavani; Yi Xiu-Yu; Falck J R; Campbell William B
Characterization of 14,15-epoxyeicosatrienoyl-sulfonamides as 14,15-epoxyeicosatrienoic acid agonists: use for studies of metabolism and ligand binding.
The Journal of pharmacology and experimental therapeutics 2007;321(3):1023-31.
2007: Yu Ming; Lopez Bernardo; Dos Santos Elisabete A; Falck John R; Roman Richard J
Effects of 20-HETE on Na+ transport and Na+ -K+ -ATPase activity in the thick ascending loop of Henle.
American journal of physiology. Regulatory, integrative and comparative physiology 2007;292(6):R2400-5.
2007: Falck J R; Reddy L Manmohan; Byun Kihwan; Campbell William B; Yi Xiu-Yu
Epoxygenase eicosanoids: synthesis of tetrahydrofuran-diol metabolites and their vasoactivity.
Bioorganic & medicinal chemistry letters 2007;17(9):2634-8.
2007: Chen Yue; Sprung Robert; Tang Yi; Ball Haydn; Sangras Bhavani; Kim Sung Chan; Falck John R; Peng Junmin; Gu Wei; Zhao Yingming
Lysine propionylation and butyrylation are novel post-translational modifications in histones.
Molecular & cellular proteomics : MCP 2007;6(5):812-9.
2007: Yi Xiu-Yu; Gauthier Kathryn M; Cui Lijie; Nithipatikom Kasem; Falck John R; Campbell William B
Metabolism of adrenic acid to vasodilatory 1alpha,1beta-dihomo-epoxyeicosatrienoic acids by bovine coronary arteries.
American journal of physiology. Heart and circulatory physiology 2007;292(5):H2265-74.
2007: Chen Jianchun; Chen Jian-Kang; Falck John R; Guthi Jagadeesh Setti; Anjaiah Siddam; Capdevila Jorge H; Harris Raymond C
Mitogenic activity and signaling mechanism of 2-(14,15- epoxyeicosatrienoyl)glycerol, a novel cytochrome p450 arachidonate metabolite.
Molecular and cellular biology 2007;27(8):3023-34.
2007: Gross Garrett J; Hsu Anna; Falck John R; Nithipatikom Kasem
Mechanisms by which epoxyeicosatrienoic acids (EETs) elicit cardioprotection in rat hearts.
Journal of molecular and cellular cardiology 2007;42(3):687-91.
2007: Campbell William B; Falck John R
Arachidonic acid metabolites as endothelium-derived hyperpolarizing factors.
Hypertension 2007;49(3):590-6.
2007: Dimitropoulou Christiana; West Lashondra; Field Mary B; White Richard E; Reddy L Manmohan; Falck John R; Imig John D
Protein phosphatase 2A and Ca2+-activated K+ channels contribute to 11,12-epoxyeicosatrienoic acid analog mediated mesenteric arterial relaxation.
Prostaglandins & other lipid mediators 2007;83(1-2):50-61.
2007: Falck J R; Patel Paresh K; Bandyopadhyay Anish
Stereospecific cross-coupling of alpha-(thiocarbamoyl)organostannanes with alkenyl, aryl, and heteroaryl iodides.
Journal of the American Chemical Society 2007;129(4):790-3.
2007: Fang Xiang; Dillon Joseph S; Hu Shanming; Harmon Shawn D; Yao Jianrong; Anjaiah Siddam; Falck J R; Spector Arthur A
20-carboxy-arachidonic acid is a dual activator of peroxisome proliferator-activated receptors alpha and gamma.
Prostaglandins & other lipid mediators 2007;82(1-4):175-84.
2007: Medhora Meetha; Dhanasekaran Anuradha; Gruenloh Stephanie K; Dunn Laurel K; Gabrilovich Michael; Falck John R; Harder David R; Jacobs Elizabeth R; Pratt Phillip F
Emerging mechanisms for growth and protection of the vasculature by cytochrome P450-derived products of arachidonic acid and other eicosanoids.
Prostaglandins & other lipid mediators 2007;82(1-4):19-29.
2007: Falck J R; Sangras Bhavani; Capdevila Jorge H
Preparation of N-tBoc L-glutathione dimethyl and di-tert-butyl esters: versatile synthetic building blocks.
Bioorganic & medicinal chemistry 2007;15(2):1062-6.
2007: Bejot Romain; He Anyu; Falck John R; Mioskowski Charles
Chromium-carbyne complexes: intermediates for organic synthesis.
Angewandte Chemie (International ed. in English) 2007;46(10):1719-22.
2006: Huang Hui; Chang Hsin-Hsin; Xu Yue; Reddy D Sudarshan; Du Juan; Zhou Yiqiang; Dong Zheng; Falck John R; Wang Mong-Heng
Epoxyeicosatrienoic Acid inhibition alters renal hemodynamics during pregnancy.
Experimental biology and medicine (Maywood, N.J.) 2006;231(11):1744-52.
2006: Ng Valerie Y; Morisseau Christophe; Falck John R; Hammock Bruce D; Kroetz Deanna L
Inhibition of smooth muscle proliferation by urea-based alkanoic acids via peroxisome proliferator-activated receptor alpha-dependent repression of cyclin D1.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(11):2462-8.
2006: Fang Xiang; Faraci Frank M; Kaduce Terry L; Harmon Shawn; Modrick Mary L; Hu Shanming; Moore Steven A; Falck J R; Weintraub Neal L; Spector Arthur A
20-Hydroxyeicosatetraenoic acid is a potent dilator of mouse basilar artery: role of cyclooxygenase.
American journal of physiology. Heart and circulatory physiology 2006;291(5):H2301-7.
2006: Falck J R; Bejot Romain; Barma Deb K; Bandyopadhyay Anish; Joseph Suju; Mioskowski Charles
Fe(0)-mediated synthesis of tri- and tetra-substituted olefins from carbonyls: an environmentally friendly alternative to Cr(II).
The Journal of organic chemistry 2006;71(21):8178-82.
2006: Falck J R; He Anyu; Reddy L Manmohan; Kundu Abhijit; Barma Deb K; Bandyopadhyay A; Kamila Sukanta; Akella Radha; Bejot Romain; Mioskowski Charles
Ring expansion/homologation--aldehyde condensation cascade using tert-trihalomethylcarbinols.
Organic letters 2006;8(20):4645-7.
2006: Harmon Shawn D; Fang Xiang; Kaduce Terry L; Hu Shanming; Raj Gopal V; Falck John R; Spector Arthur A
Oxygenation of omega-3 fatty acids by human cytochrome P450 4F3B: effect on 20-hydroxyeicosatetraenoic acid production.
Prostaglandins, leukotrienes, and essential fatty acids 2006;75(3):169-77.
2006: Chen Yuenmu; Medhora Meetha; Falck John R; Pritchard Kirkwood A; Jacobs Elizabeth R
Mechanisms of activation of eNOS by 20-HETE and VEGF in bovine pulmonary artery endothelial cells.
American journal of physiology. Lung cellular and molecular physiology 2006;291(3):L378-85.
2006: Nithipatikom Kasem; Moore Jeannine M; Isbell Marilyn A; Falck John R; Gross Garrett J
Epoxyeicosatrienoic acids in cardioprotection: ischemic versus reperfusion injury.
American journal of physiology. Heart and circulatory physiology 2006;291(2):H537-42.
2006: Baati Rachid; Mioskowski Charles; Barma Deb; Kache Rajashaker; Falck J R
Reductive olefination of aldehydes via chromium Brook rearrangement.
Organic letters 2006;8(14):2949-51.
2006: Carroll Mairéad A; Doumad Anabel B; Li Jing; Cheng Monica K; Falck J R; McGiff John C
Adenosine2A receptor vasodilation of rat preglomerular microvessels is mediated by EETs that activate the cAMP/PKA pathway.
American journal of physiology. Renal physiology 2006;291(1):F155-61.
2006: Rodella Luigi; Lamon Brian D; Rezzani Rita; Sangras Bhavani; Goodman Alvin I; Falck John R; Abraham Nader G
Carbon monoxide and biliverdin prevent endothelial cell sloughing in rats with type I diabetes.
Free radical biology & medicine 2006;40(12):2198-205.
2006: Nakagawa Kiyoshi; Holla Vijaykumar R; Wei Yuan; Wang Wen-Hui; Gatica Arnaldo; Wei Shouzou; Mei Shaojun; Miller Crystal M; Cha Dae Ryong; Price Edward; Zent Roy; Pozzi Ambra; Breyer Matthew D; Guan Youfei; Falck John R; Waterman Michael R; Capdevila Jorge H
Salt-sensitive hypertension is associated with dysfunctional Cyp4a10 gene and kidney epithelial sodium channel.
The Journal of clinical investigation 2006;116(6):1696-702.
2006: Wei Shouzou; Brittin James J; Falck John R; Anjaiah Siddam; Nithipatikom Kasem; Cui Lijie; Campbell William B; Capdevila Jorge H
Chiral resolution of the epoxyeicosatrienoic acids, arachidonic acid epoxygenase metabolites.
Analytical biochemistry 2006;352(1):129-34.
2006: Ye Dan; Zhou Wei; Lu Tong; Jagadeesh Setti G; Falck John R; Lee Hon-Chi
Mechanism of rat mesenteric arterial KATP channel activation by 14,15-epoxyeicosatrienoic acid.
American journal of physiology. Heart and circulatory physiology 2006;290(4):H1326-36.
2006: Jin Liming; Foss Clare E; Zhao Xueying; Mills Thomas M; Wang Mong-Heng; McCluskey Lynnette P; Yaddanapud Ganesh S S; Falck John R; Imig John D; Webb R Clinton
Cytochrome P450 epoxygenases provide a novel mechanism for penile erection.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(3):539-41.
2006: Larsen Brandon T; Miura Hiroto; Hatoum Ossama A; Campbell William B; Hammock Bruce D; Zeldin Darryl C; Falck John R; Gutterman David D
Epoxyeicosatrienoic and dihydroxyeicosatrienoic acids dilate human coronary arterioles via BK(Ca) channels: implications for soluble epoxide hydrolase inhibition.
American journal of physiology. Heart and circulatory physiology 2006;290(2):H491-9.
2006: Nithipatikom Kasem; Endsley Michael P; Moore Jeannine M; Isbell Marilyn A; Falck John R; Campbell William B; Gross Garrett J
Effects of selective inhibition of cytochrome P-450 omega-hydroxylases and ischemic preconditioning in myocardial protection.
American journal of physiology. Heart and circulatory physiology 2006;290(2):H500-5.
2006: Nandi Animesh; Sprung Robert; Barma Deb K; Zhao Yingxin; Kim Sung Chan; Falck John R; Zhao Yingming
Global identification of O-GlcNAc-modified proteins.
Analytical chemistry 2006;78(2):452-8.
2006: Du Liping; Yermalitsky Valery; Hachey David L; Jagadeesh Setti G; Falck John R; Keeney Diane S
A biosynthetic pathway generating 12-hydroxy-5,8,14-eicosatrienoic acid from arachidonic acid is active in mouse skin microsomes.
The Journal of pharmacology and experimental therapeutics 2006;316(1):371-9.
2006: Campbell William B; Holmes Blythe B; Falck John R; Capdevila Jorge H; Gauthier Kathryn M
Regulation of potassium channels in coronary smooth muscle by adenoviral expression of cytochrome P-450 epoxygenase.
American journal of physiology. Heart and circulatory physiology 2006;290(1):H64-71.
2006: Fang Xiang; Hu Shanming; Xu Bingkun; Snyder Gary D; Harmon Shawn; Yao Jianrong; Liu Yi; Sangras Bhavani; Falck J R; Weintraub Neal L; Spector Arthur A
14,15-Dihydroxyeicosatrienoic acid activates peroxisome proliferator-activated receptor-alpha.
American journal of physiology. Heart and circulatory physiology 2006;290(1):H55-63.
2006: Tang Xin; Edwards Erik M; Holmes Blythe B; Falck John R; Campbell William B
Role of phospholipase C and diacylglyceride lipase pathway in arachidonic acid release and acetylcholine-induced vascular relaxation in rabbit aorta.
American journal of physiology. Heart and circulatory physiology 2006;290(1):H37-45.
2006: Chan Kim Sung; Kho Yoonjung; Barma Deb; Falck John; Zhao Yingming
A tagging-via-substrate technology for genome-wide detection and identification of farnesylated proteins.
Methods in enzymology 2006;407():629-37.
2005: Huang Hui; Zhou Yiqiang; Raju Venugopal T; Du Juan; Chang Hsin-Hsin; Wang Cong-Yi; Brands Michael W; Falck John R; Wang Mong-Heng
Renal 20-HETE inhibition attenuates changes in renal hemodynamics induced by L-NAME treatment in pregnant rats.
American journal of physiology. Renal physiology 2005;289(5):F1116-22.
2005: Mezentsev Alexandre; Mastyugin Vladimir; Seta Francesca; Ashkar Silvia; Kemp Rowena; Reddy D Sudarshan; Falck John R; Dunn Michael W; Laniado-Schwartzman Michal
Transfection of cytochrome P4504B1 into the cornea increases angiogenic activity of the limbal vessels.
The Journal of pharmacology and experimental therapeutics 2005;315(1):42-50.
2005: Gross Garrett J; Falck John R; Gross Eric R; Isbell Marilyn; Moore Jeannine; Nithipatikom Kasem
Cytochrome P450 and arachidonic acid metabolites: role in myocardial ischemia/reperfusion injury revisited.
Cardiovascular research 2005;68(1):18-25.
2005: Collins Xixuan H; Harmon Shawn D; Kaduce Terry L; Berst Kristine B; Fang Xiang; Moore Steven A; Raju T Verugopal; Falck John R; Weintraub Neal L; Duester Gregg; Plapp Bryce V; Spector Arthur A
Omega-oxidation of 20-hydroxyeicosatetraenoic acid (20-HETE) in cerebral microvascular smooth muscle and endothelium by alcohol dehydrogenase 4.
The Journal of biological chemistry 2005;280(39):33157-64.
2005: Huang An; Sun Dong; Yan Changdong; Falck John R; Kaley Gabor
Contribution of 20-HETE to augmented myogenic constriction in coronary arteries of endothelial NO synthase knockout mice.
Hypertension 2005;46(3):607-13.
2005: Dunn Laurel K; Gruenloh Stephanie K; Dunn Bruce E; Reddy D Sudarshan; Falck John R; Jacobs Elizabeth R; Medhora Meetha
Chick chorioallantoic membrane as an in vivo model to study vasoreactivity: characterization of development-dependent hyperemia induced by epoxyeicosatrienoic acids (EETs).
The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology 2005;285(2):771-80.
2005: Liclican Elvira L; McGiff John C; Pedraza Paulina L; Ferreri Nicholas R; Falck John R; Carroll Mairead A
Exaggerated response to adenosine in kidneys from high salt-fed rats: role of epoxyeicosatrienoic acids.
American journal of physiology. Renal physiology 2005;289(2):F386-92.
2005: Pozzi Ambra; Macias-Perez Ines; Abair Tristin; Wei Shouzuo; Su Yan; Zent Roy; Falck John R; Capdevila Jorge H
Characterization of 5,6- and 8,9-epoxyeicosatrienoic acids (5,6- and 8,9-EET) as potent in vivo angiogenic lipids.
The Journal of biological chemistry 2005;280(29):27138-46.
2005: Drenjancevic-Peric Ines; Phillips Shane A; Falck John R; Lombard Julian H
Restoration of normal vascular relaxation mechanisms in cerebral arteries by chromosomal substitution in consomic SS.13BN rats.
American journal of physiology. Heart and circulatory physiology 2005;289(1):H188-95.
2005: Sprung Robert; Nandi Animesh; Chen Yue; Kim Sung Chan; Barma Deb; Falck John R; Zhao Yingming
Tagging-via-substrate strategy for probing O-GlcNAc modified proteins.
Journal of proteome research 2005;4(3):950-7.
2005: Li Volti Giovanni; Sacerdoti David; Sangras Bhavani; Vanella Angelo; Mezentsev Alexandre; Scapagnini Giovanni; Falck John R; Abraham Nader G
Carbon monoxide signaling in promoting angiogenesis in human microvessel endothelial cells.
Antioxidants & redox signaling 2005;7(5-6):704-10.
2005: Gauthier Kathryn M; Edwards Erik M; Falck John R; Reddy Dendi S; Campbell William B
14,15-epoxyeicosatrienoic acid represents a transferable endothelium-dependent relaxing factor in bovine coronary arteries.
Hypertension 2005;45(4):666-71.
2005: Yang Wenqi; Gauthier Kathryn M; Reddy L Manmohan; Sangras Bhavani; Sharma Kamalesh K; Nithipatikom Kasem; Falck John R; Campbell William B
Stable 5,6-epoxyeicosatrienoic acid analog relaxes coronary arteries through potassium channel activation.
Hypertension 2005;45(4):681-6.
2005: Wang Jingli; Roman Richard J; Falck John R; de la Cruz Lourdes; Lombard Julian H
Effects of high-salt diet on CYP450-4A omega-hydroxylase expression and active tone in mesenteric resistance arteries.
American journal of physiology. Heart and circulatory physiology 2005;288(4):H1557-65.
2005: Bejot Romain; Tisserand Steve; Reddy L Manmohan; Barma Deb K; Baati Rachid; Falck J R; Mioskowski Charles
Stereoselective transformations of trihalomethylcarbinols induced by chromous chloride.
Angewandte Chemie (International ed. in English) 2005;44(13):2008-11.
2005: Zhao Bin; Guengerich F Peter; Bellamine Aouatef; Lamb David C; Izumikawa Miho; Lei Li; Podust Larissa M; Sundaramoorthy Munirathinam; Kalaitzis John A; Reddy L Manmohan; Kelly Steven L; Moore Bradley S; Stec Donald; Voehler Markus; Falck John R; Shimada Tsutomu; Waterman Michael R
Binding of two flaviolin substrate molecules, oxidative coupling, and crystal structure of Streptomyces coelicolor A3(2) cytochrome P450 158A2.
The Journal of biological chemistry 2005;280(12):11599-607.
2005: Gauthier Kathryn M; Baewer David V; Hittner Sarah; Hillard Cecilia J; Nithipatikom Kasem; Reddy D Sudarshan; Falck J R; Campbell William B
Endothelium-derived 2-arachidonylglycerol: an intermediate in vasodilatory eicosanoid release in bovine coronary arteries.
American journal of physiology. Heart and circulatory physiology 2005;288(3):H1344-51.
2005: Huang An; Sun Dong; Jacobson Azita; Carroll Mairead A; Falck John R; Kaley Gabor
Epoxyeicosatrienoic acids are released to mediate shear stress-dependent hyperpolarization of arteriolar smooth muscle.
Circulation research 2005;96(3):376-83.
2005: Patel Sachin; Carrier Erica J; Ho W-S Vanessa; Rademacher David J; Cunningham Sonya; Reddy D Sudarshan; Falck J R; Cravatt Benjamin F; Hillard Cecilia J
The postmortal accumulation of brain N-arachidonylethanolamine (anandamide) is dependent upon fatty acid amide hydrolase activity.
Journal of lipid research 2005;46(2):342-9.
2005: Jiang Houli; Quilley John; Reddy L Manmohan; Falck John R; Wong Patrick Y K; McGiff John C
Red blood cells: reservoirs of cis- and trans-epoxyeicosatrienoic acids.
Prostaglandins & other lipid mediators 2005;75(1-4):65-78.
2005: Zhang Fan; Deng Huan; Kemp Rowena; Singh Harpreet; Gopal Venkat Raj; Falck John R; Laniado-Schwartzman Michal; Nasjletti Alberto
Decreased levels of cytochrome P450 2E1-derived eicosanoids sensitize renal arteries to constrictor agonists in spontaneously hypertensive rats.
Hypertension 2005;45(1):103-8.
2004: Nithipatikom Kasem; Endsley Michael P; Isbell Marilyn A; Falck John R; Iwamoto Yoshiki; Hillard Cecilia J; Campbell William B
2-arachidonoylglycerol: a novel inhibitor of androgen-independent prostate cancer cell invasion.
Cancer research 2004;64(24):8826-30.
2004: Gross Eric R; Nithipatikom Kasem; Hsu Anna K; Peart Jason N; Falck John R; Campbell William B; Gross Garrett J
Cytochrome P450 omega-hydroxylase inhibition reduces infarct size during reperfusion via the sarcolemmal KATP channel.
Journal of molecular and cellular cardiology 2004;37(6):1245-9.
2004: Wei Yuan; Lin Dao-Hong; Kemp Rowena; Yaddanapudi Ganesh S S; Nasjletti Alberto; Falck John R; Wang Wen-Hui
Arachidonic acid inhibits epithelial Na channel via cytochrome P450 (CYP) epoxygenase-dependent metabolic pathways.
The Journal of general physiology 2004;124(6):719-27.
2004: Zhao Xueying; Falck John R; Gopal V Raj; Inscho Edward W; Imig John D
P2X receptor-stimulated calcium responses in preglomerular vascular smooth muscle cells involves 20-hydroxyeicosatetraenoic acid.
The Journal of pharmacology and experimental therapeutics 2004;311(3):1211-7.
2004: Nithipatikom Kasem; Gross Eric R; Endsley Michael P; Moore Jeannine M; Isbell Marilyn A; Falck John R; Campbell William B; Gross Garrett J
Inhibition of cytochrome P450omega-hydroxylase: a novel endogenous cardioprotective pathway.
Circulation research 2004;95(8):e65-71.
2004: Falck J R; Barma Deb K; Mohapatra Suchismita; Bandyopadhyay A; Reddy Komandla Malla; Qi Jianjun; Campbell William B
Asymmetric synthesis of the stereoisomers of 11,12,15(S)-trihydroxyeicosa-5(Z),8(Z),13(E)-trienoic acid, a potent endothelium-derived vasodilator.
Bioorganic & medicinal chemistry letters 2004;14(19):4987-90.
2004: Zghibeh Chaza M; Raj Gopal V; Poff Candace D; Falck J R; Balazy Michael
Determination of trans-arachidonic acid isomers in human blood plasma.
Analytical biochemistry 2004;332(1):137-44.
2004: Zhang Fan; Wang Mong-Heng; Wang Ji-Shi; Zand Barbara; Gopal V Raj; Falck John R; Laniado-Schwartzman Michal; Nasjletti Alberto
Transfection of CYP4A1 cDNA decreases diameter and increases responsiveness of gracilis muscle arterioles to constrictor stimuli.
American journal of physiology. Heart and circulatory physiology 2004;287(3):H1089-95.
2004: Kho Yoonjung; Kim Sung Chan; Jiang Chen; Barma Deb; Kwon Sung Won; Cheng Jinke; Jaunbergs Janis; Weinbaum Carolyn; Tamanoi Fuyuhiko; Falck John; Zhao Yingming
A tagging-via-substrate technology for detection and proteomics of farnesylated proteins.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(34):12479-84.
2004: Kaide Jun-Ichi; Zhang Fan; Wei Yuan; Wang WenHui; Gopal Venkat Raj; Falck John R; Laniado-Schwartzman Michal; Nasjletti Alberto
Vascular CO counterbalances the sensitizing influence of 20-HETE on agonist-induced vasoconstriction.
Hypertension 2004;44(2):210-6.
2004: Jiang Houli; McGiff John C; Quilley John; Sacerdoti David; Reddy L Manmohan; Falck John R; Zhang Fan; Lerea Kenneth M; Wong Patrick Y-K
Identification of 5,6-trans-epoxyeicosatrienoic acid in the phospholipids of red blood cells.
The Journal of biological chemistry 2004;279(35):36412-8.
2004: Gauthier Kathryn M; Falck J R; Reddy L Manmohan; Campbell William B
14,15-EET analogs: characterization of structural requirements for agonist and antagonist activity in bovine coronary arteries.
Pharmacological research : the official journal of the Italian Pharmacological Society 2004;49(6):515-24.
2004: Xu Fengyun; Falck John R; Ortiz de Montellano Paul R; Kroetz Deanna L
Catalytic activity and isoform-specific inhibition of rat cytochrome p450 4F enzymes.
The Journal of pharmacology and experimental therapeutics 2004;308(3):887-95.
2004: Yu Ming; Cambj-Sapunar Liana; Kehl Franz; Maier Kristopher G; Takeuchi Kazuhiko; Miyata Noriyuki; Ishimoto Tsuyoshi; Reddy L Manmohan; Falck John R; Gebremedhin Debebe; Harder David R; Roman Richard J
Effects of a 20-HETE antagonist and agonists on cerebral vascular tone.
European journal of pharmacology 2004;486(3):297-306.
2004: Cheng M K; Doumad A B; Jiang H; Falck J R; McGiff J C; Carroll M A
Epoxyeicosatrienoic acids mediate adenosine-induced vasodilation in rat preglomerular microvessels (PGMV) via A2A receptors.
British journal of pharmacology 2004;141(3):441-8.
2004: Jiang Miao; Mezentsev Alexandre; Kemp Rowena; Byun Kihwan; Falck John R; Miano Joseph M; Nasjletti Alberto; Abraham Nader G; Laniado-Schwartzman Michal
Smooth muscle--specific expression of CYP4A1 induces endothelial sprouting in renal arterial microvessels.
Circulation research 2004;94(2):167-74.
2004: Huang An; Sun Dong; Wu Zhiping; Yan Changdong; Carroll Mairead A; Jiang Houli; Falck John R; Kaley Gabor
Estrogen elicits cytochrome P450--mediated flow-induced dilation of arterioles in NO deficiency: role of PI3K-Akt phosphorylation in genomic regulation.
Circulation research 2004;94(2):245-52.
2004: Kaduce Terry L; Fang Xiang; Harmon Shawn D; Oltman Christine L; Dellsperger Kevin C; Teesch Lynn M; Gopal V Raj; Falck J R; Campbell William B; Weintraub Neal L; Spector Arthur A
20-hydroxyeicosatetraenoic acid (20-HETE) metabolism in coronary endothelial cells.
The Journal of biological chemistry 2004;279(4):2648-56.
2004: Lombard Julian H; Frisbee Jefferson C; Roman Richard J; Falck John R
Evaluation of cytochrome P450-4A omega-hydroxylase and 20-hydroxyeicosatetraenoic acid as an O2 sensing mechanism in the microcirculation.
Methods in enzymology 2004;381():140-65.
2003: Mohapatra Suchismita; Bandyopadhyay A; Barma D K; Capdevila Jorge H; Falck J R
Chiral alpha,beta-dialkoxy- and alpha-alkoxy-beta-aminostannanes: preparation and copper-mediated cross-coupling.
Organic letters 2003;5(25):4759-62.
2003: Barma D K; Bandyopadhyay A; Capdevila Jorge H; Falck J R
Dimethylthiocarbamate (DMTC): an alcohol protecting group.
Organic letters 2003;5(25):4755-7.
2003: Falck J R; Reddy L Manmohan; Reddy Y Krishna; Bondlela Muralidhar; Krishna U Murali; Ji Yu; Sun Jianxin; Liao James K
11,12-epoxyeicosatrienoic acid (11,12-EET): structural determinants for inhibition of TNF-alpha-induced VCAM-1 expression.
Bioorganic & medicinal chemistry letters 2003;13(22):4011-4.
2003: Reddy Y Krishna; Reddy L Manmohan; Capdevila Jorge H; Falck J R
Practical, asymmetric synthesis of 16-hydroxyeicosa-5(Z),8(Z), 11(Z),14(Z)-tetraenoic acid (16-HETE), an endogenous inhibitor of neutrophil activity.
Bioorganic & medicinal chemistry letters 2003;13(21):3719-20.
2003: Gauthier Kathryn M; Jagadeesh Setti G; Falck John R; Campbell William B
14,15-epoxyeicosa-5(Z)-enoic-mSI: a 14,15- and 5,6-EET antagonist in bovine coronary arteries.
Hypertension 2003;42(4):555-61.
2003: Pomposiello Silvia I; Quilley John; Carroll Mairead A; Falck John R; McGiff John C
5,6-epoxyeicosatrienoic acid mediates the enhanced renal vasodilation to arachidonic acid in the SHR.
Hypertension 2003;42(4):548-54.
2003: Patel Sachin; Wohlfeil Eric R; Rademacher David J; Carrier Erica J; Perry LaToya J; Kundu Abhijit; Falck J R; Nithipatikom Kasem; Campbell William B; Hillard Cecilia J
The general anesthetic propofol increases brain N-arachidonylethanolamine (anandamide) content and inhibits fatty acid amide hydrolase.
British journal of pharmacology 2003;139(5):1005-13.
2003: Yu Ming; Alonso-Galicia Magdalena; Sun Cheng-Wen; Roman Richard J; Ono Naoya; Hirano Hitomi; Ishimoto Tsuyoshi; Reddy Y Krishna; Katipally Kishta Reddy; Reddy Komandla Malla; Gopal V Raj; Yu Ji; Takhi Mohamed; Falck J R
20-hydroxyeicosatetraenoic acid (20-HETE): structural determinants for renal vasoconstriction.
Bioorganic & medicinal chemistry 2003;11(13):2803-21.
2003: Pfister Sandra L; Spitzbarth Nancy; Nithipatikom Kasem; Falck John R; Campbell William B
Metabolism of 12-hydroperoxyeicosatetraenoic acid to vasodilatory trioxilin C3 by rabbit aorta.
Biochimica et biophysica acta 2003;1622(1):6-13.
2003: Kwon Sung Won; Kim Sung Chan; Jaunbergs Janis; Falck John R; Zhao Yingming
Selective enrichment of thiophosphorylated polypeptides as a tool for the analysis of protein phosphorylation.
Molecular & cellular proteomics : MCP 2003;2(4):242-7.
2003: Barma D K; Elayadi Anissa; Falck J R; Corey David R
Inhibition of telomerase by BIBR 1532 and related analogues.
Bioorganic & medicinal chemistry letters 2003;13(7):1333-6.
2003: Barma D K; Kundu Abhijit; Zhang Hongming; Mioskowski Charles; Falck J R
(Z)-alpha-haloacrylates: an exceptionally stereoselective preparation via Cr(II)-mediated olefination of aldehydes with trihaloacetates.
Journal of the American Chemical Society 2003;125(11):3218-9.
2003: Kaide Jun-Ichi; Wang Mong-Heng; Wang Ji-Shi; Zhang Fan; Gopal V Raj; Falck John R; Nasjletti Alberto; Laniado-Schwartzman Michal
Transfection of CYP4A1 cDNA increases vascular reactivity in renal interlobar arteries.
American journal of physiology. Renal physiology 2003;284(1):F51-6.
2003: Falck J R; Krishna U Murali; Reddy Y Krishna; Kumar P Srinagesh; Reddy K Malla; Hittner Sarah B; Deeter Christine; Sharma Kamalesh K; Gauthier Kathryn M; Campbell William B
Comparison of vasodilatory properties of 14,15-EET analogs: structural requirements for dilation.
American journal of physiology. Heart and circulatory physiology 2003;284(1):H337-49.
2002: Snyder Gary D; Krishna U Murali; Falck J R; Spector Arthur A
Evidence for a membrane site of action for 14,15-EET on expression of aromatase in vascular smooth muscle.
American journal of physiology. Heart and circulatory physiology 2002;283(5):H1936-42.
2002: Looft-Wilson Robin C; Falck John R; Krishna U Murali; Gisolfi Carl V
20-HETE pathway antagonists inhibit rat small mesenteric artery tone.
Microvascular research 2002;64(2):349-352.
2002: Cowart L Ashley; Wei Shouzuo; Hsu Mei-Hui; Johnson Eric F; Krishna Murali U; Falck John R; Capdevila Jorge H
The CYP4A isoforms hydroxylate epoxyeicosatrienoic acids to form high affinity peroxisome proliferator-activated receptor ligands.
The Journal of biological chemistry 2002;277(38):35105-12.
2002: Capdevila Jorge H; Falck John R
Biochemical and molecular properties of the cytochrome P450 arachidonic acid monooxygenases.
Prostaglandins & other lipid mediators 2002;68-69():325-44.
2002: Frisbee Jefferson C; Maier Kristopher G; Falck John R; Roman Richard J; Lombard Julian H
Integration of hypoxic dilation signaling pathways for skeletal muscle resistance arteries.
American journal of physiology. Regulatory, integrative and comparative physiology 2002;283(2):R309-19.
2002: Capdevila J H; Harris R C; Falck J R
Microsomal cytochrome P450 and eicosanoid metabolism.
Cellular and molecular life sciences : CMLS 2002;59(5):780-9.
2002: Gauthier Kathryn M; Deeter Christina; Krishna U Murali; Reddy Y Krishna; Bondlela Muralidhar; Falck J R; Campbell William B
14,15-Epoxyeicosa-5(Z)-enoic acid: a selective epoxyeicosatrienoic acid antagonist that inhibits endothelium-dependent hyperpolarization and relaxation in coronary arteries.
Circulation research 2002;90(9):1028-36.
2002: Campbell William B; Deeter Christine; Gauthier Kathryn M; Ingraham Richard H; Falck J R; Li Pin-Lan
14,15-Dihydroxyeicosatrienoic acid relaxes bovine coronary arteries by activation of K(Ca) channels.
American journal of physiology. Heart and circulatory physiology 2002;282(5):H1656-64.
2002: Zeng Wei-Zhong; Liou Horng-Huei; Krishna U Murali; Falck J R; Huang Chou-Long
Structural determinants and specificities for ROMK1-phosphoinositide interaction.
American journal of physiology. Renal physiology 2002;282(5):F826-34.
2002: Mezentsev Alexander; Seta Francesca; Dunn Michael W; Ono Naoya; Falck John R; Laniado-Schwartzman Michal
Eicosanoid regulation of vascular endothelial growth factor expression and angiogenesis in microvessel endothelial cells.
The Journal of biological chemistry 2002;277(21):18670-6.
2002: Barma D K; Kundu Abhijit; Baati Rachid; Mioskowski Charles; Falck J R
A convenient preparation of 3-substituted furans: synthesis of perillene and dendrolasin.
Organic letters 2002;4(8):1387-9.
2002: Reddy Y Krishna; Falck J R
Asymmetric total synthesis of (+)-fostriecin.
Organic letters 2002;4(6):969-71.
2001: Barma D K; Baati R; Valleix A; Mioskowski C; Falck J R
Chromium vinylidene carbenoids: stereospecific synthesis of (Z)-2-chloroalk-2-en-1-ols.
Organic letters 2001;3(26):4237-8.
2001: Kunert M P; Roman R J; Falck J R; Lombard J H
Differential effect of cytochrome P-450 omega-hydroxylase inhibition on O2-induced constriction of arterioles in SHR with early and established hypertension.
Microcirculation (New York, N.Y. : 1994) 2001;8(6):435-43.
2001: Zhang F; Wang M H; Krishna U M; Falck J R; Laniado-Schwartzman M; Nasjletti A
Modulation by 20-HETE of phenylephrine-induced mesenteric artery contraction in spontaneously hypertensive and Wistar-Kyoto rats.
Hypertension 2001;38(6):1311-5.
2001: Nithipatikom K; Grall A J; Holmes B B; Harder D R; Falck J R; Campbell W B
Liquid chromatographic-electrospray ionization-mass spectrometric analysis of cytochrome P450 metabolites of arachidonic acid.
Analytical biochemistry 2001;298(2):327-36.
2001: Frisbee J C; Krishna U M; Falck J R; Lombard J H
Role of prostanoids and 20-HETE in mediating oxygen-induced constriction of skeletal muscle resistance arteries.
Microvascular research 2001;62(3):271-83.
2001: Falck J R; Bondlela M; Venkataraman S K; Srinivas D
Bromo-boronolactonization of olefins.
The Journal of organic chemistry 2001;66(21):7148-50.
2001: Gu R M; Wei Y; Falck J R; Krishna U M; Wang W H
Effects of protein tyrosine kinase and protein tyrosine phosphatase on apical K(+) channels in the TAL.
American journal of physiology. Cell physiology 2001;281(4):C1188-95.
2001: Baati R; Barma D K; Falck J R; Mioskowski C
Chromium vinylidene carbenoids: generation, characterization, and reactivity. First evidence for an internal proton return phenomenon with vinylidene carbenoids.
Journal of the American Chemical Society 2001;123(37):9196-7.
2001: Krishna U M; Reddy M M; Xia J; Falck J R; Balazy M
Stereospecific synthesis of trans-arachidonic acids.
Bioorganic & medicinal chemistry letters 2001;11(18):2415-8.
2001: Frisbee J C; Roman R J; Krishna U M; Falck J R; Lombard J H
Relative contributions of cyclooxygenase- and cytochrome P450 omega-hydroxylase-dependent pathways to hypoxic dilation of skeletal muscle resistance arteries.
Journal of vascular research 2001;38(4):305-14.
2001: Capdevila J H; Falck J R
The CYP P450 arachidonic acid monooxygenases: from cell signaling to blood pressure regulation.
Biochemical and biophysical research communications 2001;285(3):571-6.
2001: Campbell W B; Falck J R; Gauthier K
Role of epoxyeicosatrienoic acids as endothelium-derived hyperpolarizing factor in bovine coronary arteries.
Medical science monitor : international medical journal of experimental and clinical research 2001;7(4):578-84.
2001: Huang A; Sun D; Carroll M A; Jiang H; Smith C J; Connetta J A; Falck J R; Shesely E G; Koller A; Kaley G
EDHF mediates flow-induced dilation in skeletal muscle arterioles of female eNOS-KO mice.
American journal of physiology. Heart and circulatory physiology 2001;280(6):H2462-9.
2001: Wu Y; Huang A; Sun D; Falck J R; Koller A; Kaley G
Gender-specific compensation for the lack of NO in the mediation of flow-induced arteriolar dilation.
American journal of physiology. Heart and circulatory physiology 2001;280(6):H2456-61.
2001: Nithipatikom K; DiCamelli R F; Kohler S; Gumina R J; Falck J R; Campbell W B; Gross G J
Determination of cytochrome P450 metabolites of arachidonic acid in coronary venous plasma during ischemia and reperfusion in dogs.
Analytical biochemistry 2001;292(1):115-24.
2001: Frisbee J C; Roman R J; Murali Krishna U; Falck J R; Lombard J H
Altered mechanisms underlying hypoxic dilation of skeletal muscle resistance arteries of hypertensive versus normotensive Dahl rats.
Microcirculation (New York, N.Y. : 1994) 2001;8(2):115-27.
2001: Holla V R; Adas F; Imig J D; Zhao X; Price E; Olsen N; Kovacs W J; Magnuson M A; Keeney D S; Breyer M D; Falck J R; Waterman M R; Capdevila J H
Alterations in the regulation of androgen-sensitive Cyp 4a monooxygenases cause hypertension.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(9):5211-6.
2001: Kunert M P; Roman R J; Alonso-Galicia M; Falck J R; Lombard J H
Cytochrome P-450 omega-hydroxylase: a potential O(2) sensor in rat arterioles and skeletal muscle cells.
American journal of physiology. Heart and circulatory physiology 2001;280(4):H1840-5.
2001: Cowart L A; Falck J R; Capdevila J H
Structural determinants of active site binding affinity and metabolism by cytochrome P450 BM-3.
Archives of biochemistry and biophysics 2001;387(1):117-24.
2001: Pomposiello S I; Carroll M A; Falck J R; McGiff J C
Epoxyeicosatrienoic acid-mediated renal vasodilation to arachidonic acid is enhanced in SHR.
Hypertension 2001;37(3):887-93.
2001: Frisbee J C; Roman R J; Krishna U M; Falck J R; Lombard J H
20-HETE modulates myogenic response of skeletal muscle resistance arteries from hypertensive Dahl-SS rats.
American journal of physiology. Heart and circulatory physiology 2001;280(3):H1066-74.
2001: Frisbee J C; Roman R J; Falck J R; Krishna U M; Lombard J H
20-HETE contributes to myogenic activation of skeletal muscle resistance arteries in Brown Norway and Sprague-Dawley rats.
Microcirculation (New York, N.Y. : 1994) 2001;8(1):45-55.
2000: Zhu D; Birks E K; Dawson C A; Patel M; Falck J R; Presberg K; Roman R J; Jacobs E R
Hypoxic pulmonary vasoconstriction is modified by P-450 metabolites.
American journal of physiology. Heart and circulatory physiology 2000;279(4):H1526-33.
2000: Hoch U; Falck J R; de Montellano P R
Molecular basis for the omega-regiospecificity of the CYP4A2 and CYP4A3 fatty acid hydroxylases.
The Journal of biological chemistry 2000;275(35):26952-8.
2000: Capdevila J H; Falck J R
Biochemical and molecular characteristics of the cytochrome P450 arachidonic acid monooxygenase.
Prostaglandins & other lipid mediators 2000;62(3):271-92.
2000: Falck J R; Krishna U M; Capdevila J H
Preparation of L-alpha-phosphatidyl-D-myo-inositol 3-phosphate (3-PIP) and 3,5-bisphosphate (3,5-PIP2).
Bioorganic & medicinal chemistry letters 2000;10(15):1711-3.
2000: Maier K G; Henderson L; Narayanan J; Alonso-Galicia M; Falck J R; Roman R J
Fluorescent HPLC assay for 20-HETE and other P-450 metabolites of arachidonic acid.
American journal of physiology. Heart and circulatory physiology 2000;279(2):H863-71.
2000: Sun C W; Falck J R; Okamoto H; Harder D R; Roman R J
Role of cGMP versus 20-HETE in the vasodilator response to nitric oxide in rat cerebral arteries.
American journal of physiology. Heart and circulatory physiology 2000;279(1):H339-50.
2000: Gebremedhin D; Lange A R; Lowry T F; Taheri M R; Birks E K; Hudetz A G; Narayanan J; Falck J R; Okamoto H; Roman R J; Nithipatikom K; Campbell W B; Harder D R
Production of 20-HETE and its role in autoregulation of cerebral blood flow.
Circulation research 2000;87(1):60-5.
2000: Quigley R; Baum M; Reddy K M; Griener J C; Falck J R
Effects of 20-HETE and 19(S)-HETE on rabbit proximal straight tubule volume transport.
American journal of physiology. Renal physiology 2000;278(6):F949-53.
2000: Popov S G; Krishna U M; Falck J R; Wilkie T M
Ca2+/Calmodulin reverses phosphatidylinositol 3,4, 5-trisphosphate-dependent inhibition of regulators of G protein-signaling GTPase-activating protein activity.
The Journal of biological chemistry 2000;275(25):18962-8.
2000: Frisbee J C; Falck J R; Lombard J H
Contribution of cytochrome P-450 omega-hydroxylase to altered arteriolar reactivity with high-salt diet and hypertension.
American journal of physiology. Heart and circulatory physiology 2000;278(5):H1517-26.
2000: Glouchankova L; Krishna U M; Potter B V; Falck J R; Bezprozvanny I
Association of the inositol (1,4,5)-trisphosphate receptor ligand binding site with phosphatidylinositol (4,5)-bisphosphate and adenophostin A.
Molecular cell biology research communications : MCBRC 2000;3(3):153-8.
2000: Baati R; Valleix A; Mioskowski C; Barma D K; Falck J R
A convenient synthesis of 2-tetrahydrofuranyl ethers.
Organic letters 2000;2(4):485-7.
2000: Capdevila J H; Falck J R; Harris R C
Cytochrome P450 and arachidonic acid bioactivation. Molecular and functional properties of the arachidonate monooxygenase.
Journal of lipid research 2000;41(2):163-81.
2000: Zhu D; Bousamra M; Zeldin D C; Falck J R; Townsley M; Harder D R; Roman R J; Jacobs E R
Epoxyeicosatrienoic acids constrict isolated pressurized rabbit pulmonary arteries.
American journal of physiology. Lung cellular and molecular physiology 2000;278(2):L335-43.
1999: Alonso-Galicia M; Falck J R; Reddy K M; Roman R J
20-HETE agonists and antagonists in the renal circulation.
The American journal of physiology 1999;277(5 Pt 2):F790-6.
1999: Nguyen X; Wang M H; Reddy K M; Falck J R; Schwartzman M L
Kinetic profile of the rat CYP4A isoforms: arachidonic acid metabolism and isoform-specific inhibitors.
The American journal of physiology 1999;276(6 Pt 2):R1691-700.
1999: Truan G; Komandla M R; Falck J R; Peterson J A
P450BM-3: absolute configuration of the primary metabolites of palmitic acid.
Archives of biochemistry and biophysics 1999;366(2):192-8.
1999: Capdevila J H; Holla V; Helvig C; Falck J R
Microsomal cytochrome P450 and eicosanoid metabolism.
Molecular aspects of medicine 1999;20(1-2):42-55, 56-137.
1999: Chen J K; Wang D W; Falck J R; Capdevila J; Harris R C
Transfection of an active cytochrome P450 arachidonic acid epoxygenase indicates that 14,15-epoxyeicosatrienoic acid functions as an intracellular second messenger in response to epidermal growth factor.
The Journal of biological chemistry 1999;274(8):4764-9.
1999: Jacobs E R; Effros R M; Falck J R; Reddy K M; Campbell W B; Zhu D
Airway synthesis of 20-hydroxyeicosatetraenoic acid: metabolism by cyclooxygenase to a bronchodilator.
The American journal of physiology 1999;276(2 Pt 1):L280-8.
1999: Lombard J H; Kunert M P; Roman R J; Falck J R; Harder D R; Jackson W F
Cytochrome P-450 omega-hydroxylase senses O2 in hamster muscle, but not cheek pouch epithelium, microcirculation.
The American journal of physiology 1999;276(2 Pt 2):H503-8.
1999: Sun C W; Falck J R; Harder D R; Roman R J
Role of tyrosine kinase and PKC in the vasoconstrictor response to 20-HETE in renal arterioles.
Hypertension 1999;33(1 Pt 2):414-8.
1999: Rzigalinski B A; Willoughby K A; Hoffman S W; Falck J R; Ellis E F
Calcium influx factor, further evidence it is 5, 6-epoxyeicosatrienoic acid.
The Journal of biological chemistry 1999;274(1):175-82.
1998: Vafeas C; Mieyal P A; Urbano F; Falck J R; Chauhan K; Berman M; Schwartzman M L
Hypoxia stimulates the synthesis of cytochrome P450-derived inflammatory eicosanoids in rabbit corneal epithelium.
The Journal of pharmacology and experimental therapeutics 1998;287(3):903-10.
1998: Sun C W; Alonso-Galicia M; Taheri M R; Falck J R; Harder D R; Roman R J
Nitric oxide-20-hydroxyeicosatetraenoic acid interaction in the regulation of K+ channel activity and vascular tone in renal arterioles.
Circulation research 1998;83(11):1069-79.
1998: Pfister S L; Spitzbarth N; Nithipatikom K; Edgemond W S; Falck J R; Campbell W B
Identification of the 11,14,15- and 11,12, 15-trihydroxyeicosatrienoic acids as endothelium-derived relaxing factors of rabbit aorta.
The Journal of biological chemistry 1998;273(47):30879-87.
1998: Chen J K; Falck J R; Reddy K M; Capdevila J; Harris R C
Epoxyeicosatrienoic acids and their sulfonimide derivatives stimulate tyrosine phosphorylation and induce mitogenesis in renal epithelial cells.
The Journal of biological chemistry 1998;273(44):29254-61.
1998: Alonso-Galicia M; Sun C W; Falck J R; Harder D R; Roman R J
Contribution of 20-HETE to the vasodilator actions of nitric oxide in renal arteries.
The American journal of physiology 1998;275(3 Pt 2):F370-8.
1998: Fulton D; Falck J R; McGiff J C; Carroll M A; Quilley J
A method for the determination of 5,6-EET using the lactone as an intermediate in the formation of the diol.
Journal of lipid research 1998;39(8):1713-21.
1998: Edgemond W S; Hillard C J; Falck J R; Kearn C S; Campbell W B
Human platelets and polymorphonuclear leukocytes synthesize oxygenated derivatives of arachidonylethanolamide (anandamide): their affinities for cannabinoid receptors and pathways of inactivation.
Molecular pharmacology 1998;54(1):180-8.
1998: Lupu V D; Kaznacheyeva E; Krishna U M; Falck J R; Bezprozvanny I
Functional coupling of phosphatidylinositol 4,5-bisphosphate to inositol 1,4,5-trisphosphate receptor.
The Journal of biological chemistry 1998;273(23):14067-70.
1998: Wang M H; Brand-Schieber E; Zand B A; Nguyen X; Falck J R; Balu N; Schwartzman M L
Cytochrome P450-derived arachidonic acid metabolism in the rat kidney: characterization of selective inhibitors.
The Journal of pharmacology and experimental therapeutics 1998;284(3):966-73.
1998: Pratt P F; Falck J R; Reddy K M; Kurian J B; Campbell W B
20-HETE relaxes bovine coronary arteries through the release of prostacyclin.
Hypertension 1998;31(1 Pt 2):237-41.
1997: Carroll M A; Balazy M; Huang D D; Rybalova S; Falck J R; McGiff J C
Cytochrome P450-derived renal HETEs: storage and release.
Kidney international 1997;51(6):1696-702.
1997: Nithipatikom K; Falck J R; Bhatt R K; Hanke C J; Campbell W B
Determination of 14,15-epoxyeicosatrienoic acid and 14,15-dihydroxyeicosatrienoic acid by fluoroimmunoassay.
Analytical biochemistry 1997;246(2):253-9.
1997: Alonso-Galicia M; Drummond H A; Reddy K K; Falck J R; Roman R J
Inhibition of 20-HETE production contributes to the vascular responses to nitric oxide.
Hypertension 1997;29(1 Pt 2):320-5.
1997: Graham-Lorence S; Truan G; Peterson J A; Falck J R; Wei S; Helvig C; Capdevila J H
An active site substitution, F87V, converts cytochrome P450 BM-3 into a regio- and stereoselective (14S,15R)-arachidonic acid epoxygenase.
The Journal of biological chemistry 1997;272(2):1127-35.
1997: Mao K; Reddy K K; Falck J R; McGiff J C; Balazy M
New group of lipid mediators containing omega-hydroxyarachadonic acid (20-HETE).
Advances in experimental medicine and biology 1997;433():55-9.
1996: Lu M; Zhu Y; Balazy M; Reddy K M; Falck J R; Wang W
Effect of angiotensin II on the apical K+ channel in the thick ascending limb of the rat kidney.
The Journal of general physiology 1996;108(6):537-47.
1996: Makita K; Falck J R; Capdevila J H
Cytochrome P450, the arachidonic acid cascade, and hypertension: new vistas for an old enzyme system.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1996;10(13):1456-63.
1996: Doerrler W T; Ye J; Falck J R; Lehrman M A
Acylation of glucosaminyl phosphatidylinositol revisited. Palmitoyl-CoA dependent palmitoylation of the inositol residue of a synthetic dioctanoyl glucosaminyl phosphatidylinositol by hamster membranes permits efficient mannosylation of the glucosamine residue.
The Journal of biological chemistry 1996;271(43):27031-8.
1996: Carroll M A; Balazy M; Margiotta P; Huang D D; Falck J R; McGiff J C
Cytochrome P-450-dependent HETEs: profile of biological activity and stimulation by vasoactive peptides.
The American journal of physiology 1996;271(4 Pt 2):R863-9.
1996: Capdevila J H; Wei S; Helvig C; Falck J R; Belosludtsev Y; Truan G; Graham-Lorence S E; Peterson J A
The highly stereoselective oxidation of polyunsaturated fatty acids by cytochrome P450BM-3.
The Journal of biological chemistry 1996;271(37):22663-71.
1996: Zou A P; Fleming J T; Falck J R; Jacobs E R; Gebremedhin D; Harder D R; Roman R J
Stereospecific effects of epoxyeicosatrienoic acids on renal vascular tone and K(+)-channel activity.
The American journal of physiology 1996;270(5 Pt 2):F822-32.
1996: Rosolowsky M; Falck J R; Campbell W B
Metabolism of arachidonic acid by canine polymorphonuclear leukocytes synthesis of lipoxygenase and omega-oxidized metabolites.
Biochimica et biophysica acta 1996;1300(2):143-50.
1996: Zou A P; Fleming J T; Falck J R; Jacobs E R; Gebremedhin D; Harder D R; Roman R J
20-HETE is an endogenous inhibitor of the large-conductance Ca(2+)-activated K+ channel in renal arterioles.
The American journal of physiology 1996;270(1 Pt 2):R228-37.
1996: Imig J D; Zou A P; Stec D E; Harder D R; Falck J R; Roman R J
Formation and actions of 20-hydroxyeicosatetraenoic acid in rat renal arterioles.
The American journal of physiology 1996;270(1 Pt 2):R217-27.
1995: Hildebrandt E; Albanesi J P; Falck J R; Campbell W B
Regulation of calcium influx and catecholamine secretion in chromaffin cells by a cytochrome P450 metabolite of arachidonic acid.
Journal of lipid research 1995;36(12):2599-608.
1995: Lin F; Rios A; Falck J R; Belosludtsev Y; Schwartzman M L
20-Hydroxyeicosatetraenoic acid is formed in response to EGF and is a mitogen in rat proximal tubule.
The American journal of physiology 1995;269(6 Pt 2):F806-16.
1995: Zeldin D C; DuBois R N; Falck J R; Capdevila J H
Molecular cloning, expression and characterization of an endogenous human cytochrome P450 arachidonic acid epoxygenase isoform.
Archives of biochemistry and biophysics 1995;322(1):76-86.
1995: Sakairi Y; Jacobson H R; Noland T D; Capdevila J H; Falck J R; Breyer M D
5,6-EET inhibits ion transport in collecting duct by stimulating endogenous prostaglandin synthesis.
The American journal of physiology 1995;268(5 Pt 2):F931-9.
1995: Zeldin D C; Plitman J D; Kobayashi J; Miller R F; Snapper J R; Falck J R; Szarek J L; Philpot R M; Capdevila J H
The rabbit pulmonary cytochrome P450 arachidonic acid metabolic pathway: characterization and significance.
The Journal of clinical investigation 1995;95(5):2150-60.
1995: Zou A P; Muirhead E E; Cowley A W; Mattson D L; Falck J R; Jiang J; Roman R J
Role of changes in renal hemodynamics and P-450 metabolites of arachidonic acid in the reversal of one-kidney, one clip hypertension.
Journal of hypertension 1995;13(5):557-66.
1995: Capdevila J H; Morrow J D; Belosludtsev Y Y; Beauchamp D R; DuBois R N; Falck J R
The catalytic outcomes of the constitutive and the mitogen inducible isoforms of prostaglandin H2 synthase are markedly affected by glutathione and glutathione peroxidase(s).
Biochemistry 1995;34(10):3325-37.
1995: Zeldin D C; Wei S; Falck J R; Hammock B D; Snapper J R; Capdevila J H
Metabolism of epoxyeicosatrienoic acids by cytosolic epoxide hydrolase: substrate structural determinants of asymmetric catalysis.
Archives of biochemistry and biophysics 1995;316(1):443-51.
1995: Conners M S; Schwartzman M L; Quan X; Heilman E; Chauhan K; Falck J R; Godfrey H P
Enhancement of delayed hypersensitivity inflammatory reactions in guinea pig skin by 12(R)-hydroxy-5,8,14-eicosatrienoic acid.
The Journal of investigative dermatology 1995;104(1):47-51.
1994: Makita K; Takahashi K; Karara A; Jacobson H R; Falck J R; Capdevila J H
Experimental and/or genetically controlled alterations of the renal microsomal cytochrome P450 epoxygenase induce hypertension in rats fed a high salt diet.
The Journal of clinical investigation 1994;94(6):2414-20.
1994: Laniado-Schwartzman M; Lavrovsky Y; Stoltz R A; Conners M S; Falck J R; Chauhan K; Abraham N G
Activation of nuclear factor kappa B and oncogene expression by 12(R)-hydroxyeicosatrienoic acid, an angiogenic factor in microvessel endothelial cells.
The Journal of biological chemistry 1994;269(39):24321-7.
1994: Zou A P; Imig J D; Ortiz de Montellano P R; Sui Z; Falck J R; Roman R J
Effect of P-450 omega-hydroxylase metabolites of arachidonic acid on tubuloglomerular feedback.
The American journal of physiology 1994;266(6 Pt 2):F934-41.
1994: Escalante B; Erlij D; Falck J R; McGiff J C
Cytochrome P-450 arachidonate metabolites affect ion fluxes in rabbit medullary thick ascending limb.
The American journal of physiology 1994;266(6 Pt 1):C1775-82.
1994: Harder D R; Gebremedhin D; Narayanan J; Jefcoat C; Falck J R; Campbell W B; Roman R
Formation and action of a P-450 4A metabolite of arachidonic acid in cat cerebral microvessels.
The American journal of physiology 1994;266(5 Pt 2):H2098-107.
1994: Yamamoto S; Nishimura M; Conners M S; Stoltz R A; Falck J R; Chauhan K; Laniado-Schwartzman M
Oxidation and keto reduction of 12-hydroxy-5,8,10,14-eicosatetraenoic acids in bovine corneal epithelial microsomes.
Biochimica et biophysica acta 1994;1210(2):217-25.
1993: Macica C; Balazy M; Falck J R; Mioskowski C; Carroll M A
Characterization of cytochrome P-450-dependent arachidonic acid metabolism in rabbit intestine.
The American journal of physiology 1993;265(4 Pt 1):G735-41.
1993: Imig J D; Falck J R; Gebremedhin D; Harder D R; Roman R J
Elevated renovascular tone in young spontaneously hypertensive rats. Role of cytochrome P-450.
Hypertension 1993;22(3):357-64.
1993: Karara A; Makita K; Jacobson H R; Falck J R; Guengerich F P; DuBois R N; Capdevila J H
Molecular cloning, expression, and enzymatic characterization of the rat kidney cytochrome P-450 arachidonic acid epoxygenase.
The Journal of biological chemistry 1993;268(18):13565-70.
1993: Carroll M A; Balazy M; Margiotta P; Falck J R; McGiff J C
Renal vasodilator activity of 5,6-epoxyeicosatrienoic acid depends upon conversion by cyclooxygenase and release of prostaglandins.
The Journal of biological chemistry 1993;268(17):12260-6.
1993: Escalante B; Omata K; Sessa W; Lee S G; Falck J R; Schwartzman M L
20-hydroxyeicosatetraenoic acid is an endothelium-dependent vasoconstrictor in rabbit arteries.
European journal of pharmacology 1993;235(1):1-7.
1993: Zeldin D C; Kobayashi J; Falck J R; Winder B S; Hammock B D; Snapper J R; Capdevila J H
Regio- and enantiofacial selectivity of epoxyeicosatrienoic acid hydration by cytosolic epoxide hydrolase.
The Journal of biological chemistry 1993;268(9):6402-7.
1993: Ma Y H; Gebremedhin D; Schwartzman M L; Falck J R; Clark J E; Masters B S; Harder D R; Roman R J
20-Hydroxyeicosatetraenoic acid is an endogenous vasoconstrictor of canine renal arcuate arteries.
Circulation research 1993;72(1):126-36.
1993: Escalante B; Erlij D; Falck J R; McGiff J C
Cytochrome P450-dependent arachidonate metabolites affect renal transport in the rabbit.
Journal of cardiovascular pharmacology 1993;22 Suppl 2():S106-8.
1992: Capdevila J H; Wei S; Kumar A; Kobayashi J; Snapper J R; Zeldin D C; Bhatt R K; Falck J R
Resolution of dihydroxyeicosanoates and of dihydroxyeicosatrienoates by chiral phase chromatography.
Analytical biochemistry 1992;207(2):236-40.
1992: Henrich W L; Falck J R; Campbell W B
Inhibition of renin secretion from rat renal cortical slices by (R)-12-HETE.
The American journal of physiology 1992;263(4 Pt 2):F665-70.
1992: Capdevila J H; Wei S; Yan J; Karara A; Jacobson H R; Falck J R; Guengerich F P; DuBois R N
Cytochrome P-450 arachidonic acid epoxygenase. Regulatory control of the renal epoxygenase by dietary salt loading.
The Journal of biological chemistry 1992;267(30):21720-6.
1992: Gebremedhin D; Ma Y H; Falck J R; Roman R J; VanRollins M; Harder D R
Mechanism of action of cerebral epoxyeicosatrienoic acids on cerebral arterial smooth muscle.
The American journal of physiology 1992;263(2 Pt 2):H519-25.
1992: Prakash C; Zhang J Y; Falck J R; Chauhan K; Blair I A
20-Hydroxyeicosatetraenoic acid is excreted as a glucuronide conjugate in human urine.
Biochemical and biophysical research communications 1992;185(2):728-33.
1992: Amruthesh S C; Falck J R; Ellis E F
Brain synthesis and cerebrovascular action of epoxygenase metabolites of arachidonic acid.
Journal of neurochemistry 1992;58(2):503-10.
1992: Karara A; Wei S; Spady D; Swift L; Capdevila J H; Falck J R
Arachidonic acid epoxygenase: structural characterization and quantification of epoxyeicosatrienoates in plasma.
Biochemical and biophysical research communications 1992;182(3):1320-5.
1992: Carroll M A; Garcia M P; Falck J R; McGiff J C
Cyclooxygenase dependency of the renovascular actions of cytochrome P450-derived arachidonate metabolites.
The Journal of pharmacology and experimental therapeutics 1992;260(1):104-9.
1992: Jajoo H K; Capdevila J H; Falck J R; Bhatt R K; Blair I A
Metabolism of 12(R)-hydroxyeicosatetraenoic acid by rat liver microsomes.
Biochimica et biophysica acta 1992;1123(1):110-6.
1992: Capdevila J H; Falck J R; Estabrook R W
Cytochrome P450 and the arachidonate cascade.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1992;6(2):731-6.
1991: Nishimura M; Schwartzman M L; Falck J R; Lumin S; Zirrolli J A; Murphy R C
Metabolism of 12(R)-hydroxy-5,8,10,14-eicosatetraenoic acid (12(R)-HETE) in corneal tissues: formation of novel metabolites.
Archives of biochemistry and biophysics 1991;290(2):326-35.
1991: Schwartzman M L; Omata K; Lin F M; Bhatt R K; Falck J R; Abraham N G
Detection of 20-hydroxyeicosatetraenoic acid in rat urine.
Biochemical and biophysical research communications 1991;180(1):445-9.
1991: Katoh T; Takahashi K; Capdevila J; Karara A; Falck J R; Jacobson H R; Badr K F
Glomerular stereospecific synthesis and hemodynamic actions of 8,9-epoxyeicosatrienoic acid in rat kidney.
The American journal of physiology 1991;261(4 Pt 2):F578-86.
1991: Pfister S L; Falck J R; Campbell W B
Enhanced synthesis of epoxyeicosatrienoic acids by cholesterol-fed rabbit aorta.
The American journal of physiology 1991;261(3 Pt 2):H843-52.
1991: Karara A; Dishman E; Falck J R; Capdevila J H
Endogenous epoxyeicosatrienoyl-phospholipids. A novel class of cellular glycerolipids containing epoxidized arachidonate moieties.
The Journal of biological chemistry 1991;266(12):7561-9.
1991: Campbell W B; Brady M T; Rosolowsky L J; Falck J R
Metabolism of arachidonic acid by rat adrenal glomerulosa cells: synthesis of hydroxyeicosatetraenoic acids and epoxyeicosatrienoic acids.
Endocrinology 1991;128(4):2183-94.
1991: Masferrer J L; Rimarachin J A; Gerritsen M E; Falck J R; Yadagiri P; Dunn M W; Laniado-Schwartzman M
12(R)-hydroxyeicosatrienoic acid, a potent chemotactic and angiogenic factor produced by the cornea.
Experimental eye research 1991;52(4):417-24.
1991: Bernstrom K; Malcolm K; McGee J; Maclouf J; Levy-Toledano S; Falck J R; Fitzpatrick F A
14, 15-cis-episulfide-eicosatrienoic acid, an 'epoxygenase' eicosanoid analog, inhibits ionophore- but not thrombin-induced platelet aggregation.
Molecular pharmacology 1991;39(2):114-9.
1991: Escalante B; Erlij D; Falck J R; McGiff J C
Effect of cytochrome P450 arachidonate metabolites on ion transport in rabbit kidney loop of Henle.
Science (New York, N.Y.) 1991;251(4995):799-802.
1991: Escalante B; Erlij D; Falck J R; McGiff J C
Ion transport inhibition in the medullary thick ascending limb of Henle's loop by cytochrome P450-arachidonic acid metabolites.
Advances in prostaglandin, thromboxane, and leukotriene research 1991;21A():209-12.
1991: Rosolowsky M; Falck J R; Campbell W B
Synthesis and biological activity of epoxyeicosatrienoic acids (EETs) by cultured bovine coronary artery endothelial cells.
Advances in prostaglandin, thromboxane, and leukotriene research 1991;21A():213-6.
1991: Capdevila J H; Dishman E; Karara A; Falck J R
Cytochrome P450 arachidonic acid epoxygenase: stereochemical characterization of epoxyeicosatrienoic acids.
Methods in enzymology 1991;206():441-53.
1990: Carroll M A; Garcia M P; Falck J R; McGiff J C
5,6-epoxyeicosatrienoic acid, a novel arachidonate metabolite. Mechanism of vasoactivity in the rat.
Circulation research 1990;67(5):1082-8.
1990: Escalante B; Sessa W C; Falck J R; Yadagiri P; Schwartzman M L
Cytochrome P450-dependent arachidonic acid metabolites, 19- and 20-hydroxyeicosatetraenoic acids, enhance sodium-potassium ATPase activity in vascular smooth muscle.
Journal of cardiovascular pharmacology 1990;16(3):438-43.
1990: Karara A; Dishman E; Jacobson H; Falck J R; Capdevila J H
Arachidonic acid epoxygenase. Stereochemical analysis of the endogenous epoxyeicosatrienoic acids of human kidney cortex.
FEBS letters 1990;268(1):227-30.
1990: Capdevila J H; Karara A; Waxman D J; Martin M V; Falck J R; Guenguerich F P
Cytochrome P-450 enzyme-specific control of the regio- and enantiofacial selectivity of the microsomal arachidonic acid epoxygenase.
The Journal of biological chemistry 1990;265(19):10865-71.
1990: Falck J R; Lumin S; Blair I; Dishman E; Martin M V; Waxman D J; Guengerich F P; Capdevila J H
Cytochrome P-450-dependent oxidation of arachidonic acid to 16-, 17-, and 18-hydroxyeicosatetraenoic acids.
The Journal of biological chemistry 1990;265(18):10244-9.
1990: Takahashi K; Capdevila J; Karara A; Falck J R; Jacobson H R; Badr K F
Cytochrome P-450 arachidonate metabolites in rat kidney: characterization and hemodynamic responses.
The American journal of physiology 1990;258(4 Pt 2):F781-9.
1990: Rosolowsky M; Falck J R; Willerson J T; Campbell W B
Synthesis of lipoxygenase and epoxygenase products of arachidonic acid by normal and stenosed canine coronary arteries.
Circulation research 1990;66(3):608-21.
1990: Junier M P; Dray F; Blair I; Capdevila J; Dishman E; Falck J R; Ojeda S R
Epoxygenase products of arachidonic acid are endogenous constituents of the hypothalamus involved in D2 receptor-mediated, dopamine-induced release of somatostatin.
Endocrinology 1990;126(3):1534-40.
1990: Henrich W L; Falck J R; Campbell W B
Inhibition of renin release by 14,15-epoxyeicosatrienoic acid in renal cortical slices.
The American journal of physiology 1990;258(2 Pt 1):E269-74.
1990: Capdevila J H; Falck J R; Dishman E; Karara A
Cytochrome P-450 arachidonate oxygenase.
Methods in enzymology 1990;187():385-94.
1990: Falck J R; Yadagiri P; Capdevila J
Synthesis of epoxyeicosatrienoic acids and heteroatom analogs.
Methods in enzymology 1990;187():357-64.
1990: Malcolm K; Falck J R; Fitzpatrick F A
Novel eicosanoids generated by cytochrome P450: effects on platelet aggregation and protein phosphorylation.
Advances in prostaglandin, thromboxane, and leukotriene research 1990;20():87-94.
1989: Hirt D L; Capdevila J; Falck J R; Breyer M D; Jacobson H R
Cytochrome P450 metabolites of arachidonic acid are potent inhibitors of vasopressin action on rabbit cortical collecting duct.
The Journal of clinical investigation 1989;84(6):1805-12.
1989: Hammonds T D; Blair I A; Falck J R; Capdevila J H
Resolution of epoxyeicosatrienoate enantiomers by chiral phase chromatography.
Analytical biochemistry 1989;182(2):300-3.
1989: Karara A; Dishman E; Blair I; Falck J R; Capdevila J H
Endogenous epoxyeicosatrienoic acids. Cytochrome P-450 controlled stereoselectivity of the hepatic arachidonic acid epoxygenase.
The Journal of biological chemistry 1989;264(33):19822-7.
1989: Belardetti F; Campbell W B; Falck J R; Demontis G; Rosolowsky M
Products of heme-catalyzed transformation of the arachidonate derivative 12-HPETE open S-type K+ channels in Aplysia.
Neuron 1989;3(4):497-505.
1989: Schwartzman M L; Falck J R; Yadagiri P; Escalante B
Metabolism of 20-hydroxyeicosatetraenoic acid by cyclooxygenase. Formation and identification of novel endothelium-dependent vasoconstrictor metabolites.
The Journal of biological chemistry 1989;264(20):11658-62.
1989: Ibe B O; Falck J R; Johnson A R; Campbell W B
Regulation of synthesis of prostacyclin and HETEs in human endothelial cells.
The American journal of physiology 1989;256(6 Pt 1):C1168-75.
1989: Escalante B; Sessa W C; Falck J R; Yadagiri P; Schwartzman M L
Vasoactivity of 20-hydroxyeicosatetraenoic acid is dependent on metabolism by cyclooxygenase.
The Journal of pharmacology and experimental therapeutics 1989;248(1):229-32.
1989: Falck J R; Lumin S; Yadagiri P; Shin D S
Chemical syntheses of trioxilins.
Advances in prostaglandin, thromboxane, and leukotriene research 1989;19():635-8.
1988: Murphy R C; Falck J R; Lumin S; Yadagiri P; Zirrolli J A; Balazy M; Masferrer J L; Abraham N G; Schwartzman M L
12(R)-hydroxyeicosatrienoic acid: a vasodilator cytochrome P-450-dependent arachidonate metabolite from the bovine corneal epithelium.
The Journal of biological chemistry 1988;263(32):17197-202.
1988: Escalante B; Falck J R; Yadagiri P; Sun L M; Laniado-Schwartzman M
19(S)-hydroxyeicosatetraenoic acid is a potent stimulator of renal Na+-K+-ATPase.
Biochemical and biophysical research communications 1988;152(3):1269-74.
1988: Lapuerta L; Chacos N; Falck J R; Jacobson H; Capdevila J H
Renal microsomal cytochrome P-450 and the oxidative metabolism of arachidonic acid.
The American journal of the medical sciences 1988;295(4):275-9.
1988: Capdevila J; Gil L; Orellana M; Marnett L J; Mason J I; Yadagiri P; Falck J R
Inhibitors of cytochrome P-450-dependent arachidonic acid metabolism.
Archives of biochemistry and biophysics 1988;261(2):257-63.
1988: Capdevila J H; Mosset P; Yadagiri P; Lumin S; Falck J R
NADPH-dependent microsomal metabolism of 14,15-epoxyeicosatrienoic acid to diepoxides and epoxyalcohols.
Archives of biochemistry and biophysics 1988;261(1):122-33.
1987: Falck J R; Schueler V J; Jacobson H R; Siddhanta A K; Pramanik B; Capdevila J
Arachidonate epoxygenase: identification of epoxyeicosatrienoic acids in rabbit kidney.
Journal of lipid research 1987;28(7):840-6.
1987: Capdevila J H; Kishore V; Dishman E; Blair I A; Falck J R
A novel pool of rat liver inositol and ethanolamine phospholipids contains epoxyeicosatrienoic acids (EETs).
Biochemical and biophysical research communications 1987;146(2):638-44.
1987: Toto R; Siddhanta A; Manna S; Pramanik B; Falck J R; Capdevila J
Arachidonic acid epoxygenase: detection of epoxyeicosatrienoic acids in human urine.
Biochimica et biophysica acta 1987;919(2):132-9.
1986: Capdevila J; Yadagiri P; Manna S; Falck J R
Absolute configuration of the hydroxyeicosatetraenoic acids (HETEs) formed during catalytic oxygenation of arachidonic acid by microsomal cytochrome P-450.
Biochemical and biophysical research communications 1986;141(3):1007-11.
1986: Snyder G; Lattanzio F; Yadagiri P; Falck J R; Capdevila J
5,6-Epoxyeicosatrienoic acid mobilizes Ca2+ in anterior pituitary cells.
Biochemical and biophysical research communications 1986;139(3):1188-94.
1985: Capdevila J; Kim Y R; Martin-Wixtrom C; Falck J R; Manna S; Estabrook R W
Influence of a fibric acid type of hypolipidemic agent on the oxidative metabolism of arachidonic acid by liver microsomal cytochrome P-450.
Archives of biochemistry and biophysics 1985;243(1):8-19.
1985: Spearman M E; Prough R A; Estabrook R W; Falck J R; Manna S; Leibman K C; Murphy R C; Capdevila J
Novel glutathione conjugates formed from epoxyeicosatrienoic acids (EETs).
Archives of biochemistry and biophysics 1985;242(1):225-30.
1985: Negro-Vilar A; Snyder G D; Falck J R; Manna S; Chacos N; Capdevila J
Involvement of eicosanoids in release of oxytocin and vasopressin from the neural lobe of the rat pituitary.
Endocrinology 1985;116(6):2663-8.
1984: Capdevila J; Pramanik B; Napoli J L; Manna S; Falck J R
Arachidonic acid epoxidation: epoxyeicosatrienoic acids are endogenous constituents of rat liver.
Archives of biochemistry and biophysics 1984;231(2):511-7.
1983: Falck J R; Manna S; Moltz J; Chacos N; Capdevila J
Epoxyeicosatrienoic acids stimulate glucagon and insulin release from isolated rat pancreatic islets.
Biochemical and biophysical research communications 1983;114(2):743-9.
1983: Capdevila J; Chacos N; Falck J R; Manna S; Negro-Vilar A; Ojeda S R
Novel hypothalamic arachidonate products stimulate somatostatin release from the median eminence.
Endocrinology 1983;113(1):421-3.
1983: Chacos N; Capdevila J; Falck J R; Manna S; Martin-Wixtrom C; Gill S S; Hammock B D; Estabrook R W
The reaction of arachidonic acid epoxides (epoxyeicosatrienoic acids) with a cytosolic epoxide hydrolase.
Archives of biochemistry and biophysics 1983;223(2):639-48.
1983: Snyder G D; Capdevila J; Chacos N; Manna S; Falck J R
Action of luteinizing hormone-releasing hormone: involvement of novel arachidonic acid metabolites.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(11):3504-7.
1982: Chacos N; Falck J R; Wixtrom C; Capdevila J
Novel epoxides formed during the liver cytochrome P-450 oxidation of arachidonic acid.
Biochemical and biophysical research communications 1982;104(3):916-22.

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