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John Falck

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Kathleen M Lukaszewicz; Vijaya L Manthati; John R Falck; Julian H Lombard
Introgression of Brown Norway CYP4A genes on to the Dahl salt-sensitive background restores vascular function in SS-5(BN) consomic rats.
Mohammed A Nayeem; Isha Pradhan; John R Falck; Christophe Morisseau; S Jamal Mustafa; Darryl C Zeldin
Adenosine A2A receptor modulates vascular response in soluble epoxide hydrolase-null mice through CYP-epoxygenases and PPARγ.
Garrett J Gross; Anna Hsu; John R Falck; Eric R Gross; Kasem Nithipatikom
Factors mediating remote preconditioning of trauma in the rat heart: central role of the cytochrome p450 epoxygenase pathway in mediating infarct size reduction.

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2013: Kathleen M Lukaszewicz; Vijaya L Manthati; John R Falck; Julian H Lombard
Introgression of Brown Norway CYP4A genes on to the Dahl salt-sensitive background restores vascular function in SS-5(BN) consomic rats.
Clinical science (London, England : 1979) 2013;124(5):333-42.
2013: Mohammed A Nayeem; Isha Pradhan; John R Falck; Christophe Morisseau; S Jamal Mustafa; Darryl C Zeldin
Adenosine A2A receptor modulates vascular response in soluble epoxide hydrolase-null mice through CYP-epoxygenases and PPARγ.
American journal of physiology. Regulatory, integrative and comparative physiology 2013;304(1):R23-32.
2013: Garrett J Gross; Anna Hsu; John R Falck; Eric R Gross; Kasem Nithipatikom
Factors mediating remote preconditioning of trauma in the rat heart: central role of the cytochrome p450 epoxygenase pathway in mediating infarct size reduction.
Journal of cardiovascular pharmacology and therapeutics 2013;18(1):38-45.
2012: Chen Zhu; Gongqiang Li; Daniel H Ess; John R Falck; László Kürti
Elusive metal-free primary amination of arylboronic acids: synthetic studies and mechanism by density functional theory.
Journal of the American Chemical Society 2012;134(44):18253-6.
2012: Maia Terashvili; John R Falck; M V Nostrand; P Sarkar; David R Harder
The protective effect of astrocyte-derived 14,15-epoxyeicosatrienoic acid on hydrogen peroxide-induced cell injury in astrocyte-dopaminergic neuronal cell line co-culture.
Neuroscience 2012;223():68-76.
2012: Elizabeth R Jacobs; Meetha Medhora; Irshad Ali; Sreedhar Bodiga; Aaron M Falck; John R Falck; Anuradha Dhanasekaran
Tissue protection and endothelial cell signaling by 20-HETE analogs in intact ex vivo lung slices.
Experimental cell research 2012;318(16):2143-52.
2012: Jennifer Cheng; Yan Ding; John R Falck; Victor Garcia; Errabelli Ramu; Krutanjali Thakar; Cheng-Chia Wu; Michal Laniado Schwartzman
Induction of angiotensin-converting enzyme and activation of the renin-angiotensin system contribute to 20-hydroxyeicosatetraenoic acid-mediated endothelial dysfunction.
Arteriosclerosis, thrombosis, and vascular biology 2012;32(8):1917-24.
2012: Komal Sodhi; John R Falck; Kazuyoshi Inoue; Nitin Puri; Michal L Schwartzman; Nader G Abraham
EET agonist prevents adiposity and vascular dysfunction in rats fed a high fat diet via a decrease in Bach 1 and an increase in HO-1 levels.
Prostaglandins & other lipid mediators 2012;98(3-4):133-42.
2012: Chen Zhu; Rui Wang; John R Falck
Mild and rapid hydroxylation of aryl/heteroaryl boronic acids and boronate esters with N-oxides.
Organic letters 2012;14(13):3494-7.
2012: Chen Zhu; Rui Wang; John R Falck
Amide-directed tandem C-C/C-N bond formation through C-H activation.
Chemistry, an Asian journal 2012;7(7):1502-14.
2012: Ishfaq A Bukhari; John R Falck; Kathryn M Gauthier; John D Imig; Sreenivasulu Reddy Koduru; Abdul Jabbar Shah; Katherine A Walsh; William B Campbell
11,12,20-Trihydroxy-eicosa-8(Z)-enoic acid: a selective inhibitor of 11,12-EET-induced relaxations of bovine coronary and rat mesenteric arteries.
American journal of physiology. Heart and circulatory physiology 2012;302(8):H1574-83.
2012: XIAOGUANG LIU; Chunyuan Li; John R Falck; David R Harder; Raymond C Koehler
Relative contribution of cyclooxygenases, epoxyeicosatrienoic acids, and pH to the cerebral blood flow response to vibrissal stimulation.
American journal of physiology. Heart and circulatory physiology 2012;302(5):H1075-85.
2012: Angela P H Burgess; John R Falck; Katherine Gotlinger; Nader G Abraham; Lars Bellner; Michal L Schwartzman; Luca Vanella; Attallah Kappas
Heme oxygenase (HO-1) rescue of adipocyte dysfunction in HO-2 deficient mice via recruitment of epoxyeicosatrienoic acids (EETs) and adiponectin.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2012;29(1-2):99-110.
2011: Garrett J Gross; Jeannine Moore; John E Baker; John R Falck; Kasem Nithipatikom
Abdominal surgical incision induces remote preconditioning of trauma (RPCT) via activation of bradykinin receptors (BK2R) and the cytochrome P450 epoxygenase pathway in canine hearts.
Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy 2011;25(6):517-22.
2011: Chen Zhu; Weiqing Xie; John R Falck
Rhodium-catalyzed annulation of N-benzoylsulfonamide with isocyanide through C-H activation.
Chemistry (Weinheim an der Bergstrasse, Germany) 2011;17(45):12591-5.
2011: Luca Vanella; IGNAZIO BARBAGALLO; Angela P Burgess; John R Falck; Dong Hyun Kim; Michal L Schwartzman; Komal Sodhi; Nader G Abraham
Crosstalk between EET and HO-1 downregulates Bach1 and adipogenic marker expression in mesenchymal stem cell derived adipocytes.
Prostaglandins & other lipid mediators 2011;96(1-4):54-62.
2011: Kathryn M Gauthier; David D Gutterman; Adam Harder; John D Imig; Marilyn Isbell; Lauren Olson; John R Falck; William B Campbell
Soluble epoxide hydrolase contamination of specific catalase preparations inhibits epoxyeicosatrienoic acid vasodilation of rat renal arterioles.
American journal of physiology. Renal physiology 2011;301(4):F765-72.
2011: Austin Meng Guo; Branislava Janic; Richard J Roman; Ali S Arbab; Paul A Edwards; John R Falck; Ju Sheng; A Guillermo Scicli
The cytochrome P450 4A/F-20-hydroxyeicosatetraenoic acid system: a regulator of endothelial precursor cells derived from human umbilical cord blood.
The Journal of pharmacology and experimental therapeutics 2011;338(2):421-9.
2011: Hao Li; John R Falck; Anyu He; Lanny S Liebeskind
Stereocontrolled synthesis of α-amino-α'-alkoxy ketones by a copper-catalyzed cross-coupling of peptidic thiol esters and α-alkoxyalkylstannanes.
Organic letters 2011;13(14):3682-5.
2011: Chen Zhu; John R Falck
Alternative pathways for Heck intermediates: palladium-catalyzed oxyarylation of homoallylic alcohols.
Angewandte Chemie (International ed. in English) 2011;50(29):6626-9.
2011: John R Falck; Robert Fischer; Mohan Goli; Anne Konkel; Dominik N Müller; Narender Puli; Michael Rothe; Cosima Arnold; Gerd Wallukat; Wolf-Hagen Schunck
17(R),18(S)-epoxyeicosatetraenoic acid, a potent eicosapentaenoic acid (EPA) derived regulator of cardiomyocyte contraction: structure-activity relationships and stable analogues.
Journal of medicinal chemistry 2011;54(12):4109-18.
2011: Houli Jiang; John Quilley; Anabel B Doumad; Angela G Zhu; John R Falck; Bruce D Hammock; Charles T Stier; Mairead A Carroll
Increases in plasma trans-EETs and blood pressure reduction in spontaneously hypertensive rats.
American journal of physiology. Heart and circulatory physiology 2011;300(6):H1990-6.
2011: Yuenmu Chen; John R Falck; Vijaya L Manthati; Jawahar Lal Jat; William B Campbell
20-Iodo-14,15-epoxyeicosa-8(Z)-enoyl-3-azidophenylsulfonamide: photoaffinity labeling of a 14,15-epoxyeicosatrienoic acid receptor.
Biochemistry 2011;50(18):3840-8.
2011: Cheng-Chia Wu; Jennifer Cheng; Frank Fan Zhang; Katherine Gotlinger; Mukul Kelkar; Yilun Zhang; Jawahar L Jat; John R Falck; Michal L Schwartzman
Androgen-dependent hypertension is mediated by 20-hydroxy-5,8,11,14-eicosatetraenoic acid-induced vascular dysfunction: role of inhibitor of kappaB Kinase.
Hypertension 2011;57(4):788-94.
2011: Hong Wang; Jeffrey L Garvin; Martin A D'Ambrosio; John R Falck; Pablo Leung; Ruisheng Liu; YiLin Ren; Oscar Carretero
Heme oxygenase metabolites inhibit tubuloglomerular feedback in vivo.
American journal of physiology. Heart and circulatory physiology 2011;300(4):H1320-6.
2011: Mohammed A Nayeem; Darryl C Zeldin; Matthew A Boegehold; John R Falck
Salt modulates vascular response through adenosine A(2A) receptor in eNOS-null mice: role of CYP450 epoxygenase and soluble epoxide hydrolase.
Molecular and cellular biochemistry 2011;350(1-2):101-11.
2011: Chen Zhu; John R Falck
N-acylsulfonamide assisted tandem C-H olefination/annulation: synthesis of isoindolinones.
Organic letters 2011;13(5):1214-7.
2011: Kathryn M Gauthier; Daniel H Goldman; Nitin T Aggarwal; Yuttana Chawengsub; John R Falck; William B Campbell
Role of arachidonic acid lipoxygenase metabolites in acetylcholine-induced relaxations of mouse arteries.
American journal of physiology. Heart and circulatory physiology 2011;300(3):H725-35.
2011: Phillip G Kopf; Kathryn M Gauthier; David X Zhang; John R Falck; William B Campbell
Angiotensin II regulates adrenal vascular tone through zona glomerulosa cell-derived EETs and DHETs.
Hypertension 2011;57(2):323-9.
2011: S N Batchu; S B Lee; R S Qadhi; Ketul R Chaudhary; H El-Sikhry; R Kodela; John R Falck; John M Seubert
Cardioprotective effect of a dual acting epoxyeicosatrienoic acid analogue towards ischaemia reperfusion injury.
British journal of pharmacology 2011;162(4):897-907.
2011: Mohan Goli; Anyu He; John R Falck
Pd-catalyzed cross-coupling of α-(acyloxy)-tri-n-butylstannanes with alkenyl, aryl, and heteroaryl electrophiles.
Organic letters 2011;13(2):344-6.
2011: Ishfaq A Bukhari; Kathryn M Gauthier; Jagadeesh Setti Guthi; Bhavani Sangras; John R Falck; William B Campbell
14,15-Dihydroxy-eicosa-5(Z)-enoic acid selectively inhibits 14,15-epoxyeicosatrienoic acid-induced relaxations in bovine coronary arteries.
The Journal of pharmacology and experimental therapeutics 2011;336(1):47-55.
2010: Kasem Nithipatikom; Daniel M Brody; Alan T Tang; Vijaya L Manthati; John R Falck; Carol L Williams; William B Campbell
Inhibition of carcinoma cell motility by epoxyeicosatrienoic acid (EET) antagonists.
Cancer science 2010;101(12):2629-36.
2010: Haruki Higashimori; Víctor M Blanco; Vengopal Raju Tuniki; John R Falck; Jessica Andrea Filosa
Role of epoxyeicosatrienoic acids as autocrine metabolites in glutamate-mediated K+ signaling in perivascular astrocytes.
American journal of physiology. Cell physiology 2010;299(5):C1068-78.
2010: Komal Sodhi; Cheng-Chia Wu; Jennifer Cheng; Katherine Gotlinger; Kazuyoshi Inoue; Mohan Goli; John R Falck; Nader G Abraham; Michal L Schwartzman
CYP4A2-induced hypertension is 20-hydroxyeicosatetraenoic acid- and angiotensin II-dependent.
Hypertension 2010;56(5):871-8.
2010: Gábor Raffai; Jingli Wang; Richard J Roman; Siddam Anjaiah; Brian Weinberg; John R Falck; Julian H Lombard
Modulation by cytochrome P450-4A ω-hydroxylase enzymes of adrenergic vasoconstriction and response to reduced PO₂ in mesenteric resistance arteries of Dahl salt-sensitive rats.
Microcirculation (New York, N.Y. : 1994) 2010;17(7):525-35.
2010: Peng Sun; Dao-Hong Lin; Peng Yue; Houli Jiang; Katherine Gotlinger; Michal L Schwartzman; John R Falck; Mohan Goli; Wen-Hui Wang
High potassium intake enhances the inhibitory effect of 11,12-EET on ENaC.
Journal of the American Society of Nephrology : JASN 2010;21(10):1667-77.
2010: Mohammed A Nayeem; Darryl C Zeldin; Matthew A Boegehold; Christophe Morisseau; Anne Marowsky; Dovenia S Ponnoth; Kevin P Roush; John R Falck
Modulation by salt intake of the vascular response mediated through adenosine A(2A) receptor: role of CYP epoxygenase and soluble epoxide hydrolase.
American journal of physiology. Regulatory, integrative and comparative physiology 2010;299(1):R325-33.
2010: Garrett J Gross; John E Baker; Anna Hsu; Hsiang-En Wu; John R Falck; Kasem Nithipatikom
Evidence for a role of opioids in epoxyeicosatrienoic acid-induced cardioprotection in rat hearts.
American journal of physiology. Heart and circulatory physiology 2010;298(6):H2201-7.
2010: Megan C Yap; Morris Kostiuk; Dale Martin; Maneka A Perinpanayagam; Pieter G Hak; Anjaiah Siddam; Janaki R Majjigapu; Gurram Rajaiah; Bernd Keller; Jennifer A Prescher; Peng Wu; Carolyn R Bertozzi; John R Falck; Luc G Berthiaume
Rapid and selective detection of fatty acylated proteins using omega-alkynyl-fatty acids and click chemistry.
Journal of lipid research 2010;51(6):1566-80.
2010: De Run Li; Anyu He; John R Falck
Enantioselective, organocatalytic reduction of ketones using bifunctional thiourea-amine catalysts.
Organic letters 2010;12(8):1756-9.
2010: Sreedhar Bodiga; Stephanie K Gruenloh; Ying Gao; Vijay L Manthati; Narsimhaswamy Dubasi; John R Falck; Meetha Medhora; Elizabeth R Jacobs
20-HETE-induced nitric oxide production in pulmonary artery endothelial cells is mediated by NADPH oxidase, H2O2, and PI3-kinase/Akt.
American journal of physiology. Lung cellular and molecular physiology 2010;298(4):L564-74.
2010: Biao Lu; John R Falck
Iridium-catalyzed (Z)-trialkylsilylation of terminal olefins.
The Journal of organic chemistry 2010;75(5):1701-5.
2010: Anyu He; John R Falck
Stereospecific Suzuki cross-coupling of alkyl alpha-cyanohydrin triflates.
Journal of the American Chemical Society 2010;132(8):2524-5.
2010: Phillip G Kopf; David X Zhang; Kathryn M Gauthier; Kasem Nithipatikom; Xiu-Yu Yi; John R Falck; William B Campbell
Adrenic acid metabolites as endogenous endothelium-derived and zona glomerulosa-derived hyperpolarizing factors.
Hypertension 2010;55(2):547-54.
2010: John D Imig; Ahmed A Elmarakby; Kasem Nithipatikom; Shouzou Wei; Jorge H Capdevila; Venugopal Raju Tuniki; Bhavani Sangras; Siddam Anjaiah; Vijaya L Manthati; D Sudarshan Reddy; John R Falck
Development of epoxyeicosatrienoic acid analogs with in vivo anti-hypertensive actions.
Frontiers in physiology 2010;1():157.
2010: Jennifer Cheng; Cheng-Chia Wu; Katherine H Gotlinger; Frank Zhang; John R Falck; Dubasi Narsimhaswamy; Michal L Schwartzman
20-hydroxy-5,8,11,14-eicosatetraenoic acid mediates endothelial dysfunction via IkappaB kinase-dependent endothelial nitric-oxide synthase uncoupling.
The Journal of pharmacology and experimental therapeutics 2010;332(1):57-65.
2009: Elvira L Liclican; Anabel B Doumad; Jianjin Wang; Jing Li; John R Falck; Charles T Stier; Mairead A Carroll
Inhibition of the adenosine2A receptor-epoxyeicosatrienoic acid pathway renders Dahl salt-resistant rats hypertensive.
Hypertension 2009;54(6):1284-90.
2009: Yuenmu Chen; John R Falck; Venugopal R Tuniki; William B Campbell
20-125Iodo-14,15-epoxyeicosa-5(Z)-enoic acid: a high-affinity radioligand used to characterize the epoxyeicosatrienoic acid antagonist binding site.
The Journal of pharmacology and experimental therapeutics 2009;331(3):1137-45.
2009: Mary Pat Kunert; Jill Friesma; John R Falck; Julian H Lombard
CYP450 4A inhibition attenuates O2 induced arteriolar constriction in chronic but not acute Goldblatt hypertension.
Microvascular research 2009;78(3):442-6.
2009: Yuttana Chawengsub; Kathryn M Gauthier; Kasem Nithipatikom; Bruce D Hammock; John R Falck; Dubasi Narsimhaswamy; William B Campbell
Identification of 13-hydroxy-14,15-epoxyeicosatrienoic acid as an acid-stable endothelium-derived hyperpolarizing factor in rabbit arteries.
The Journal of biological chemistry 2009;284(45):31280-90.
2009: John R Falck; Anish Bandyopadhyay; Narender Puli; Abhijit Kundu; L Manmohan Reddy; Deb K Barma; Anyu He; Hongming Zhang; Dhurke Kashinath; Rachid Baati
Cascade synthesis of (E)-2-alkylidenecyclobutanols.
Organic letters 2009;11(20):4764-6.
2009: Kazuyoshi Inoue; Komal Sodhi; Nitin Puri; Katherine H Gotlinger; Jiang Cao; Rita Rezzani; John R Falck; Nader G Abraham; Michal Laniado-Schwartzman
Endothelial-specific CYP4A2 overexpression leads to renal injury and hypertension via increased production of 20-HETE.
American journal of physiology. Renal physiology 2009;297(4):F875-84.
2009: Talha Akbulut; Kevin R Regner; Richard J Roman; Ellis D Avner; John R Falck; Frank Park
20-HETE activates the Raf/MEK/ERK pathway in renal epithelial cells through an EGFR- and c-Src-dependent mechanism.
American journal of physiology. Renal physiology 2009;297(3):F662-70.
2009: John R Falck; Ravinder Kodela; Rajkumar Manne; Krishnam Raju Atcha; Narender Puli; Narsimhaswamy Dubasi; Vijay L Manthati; Jorge H Capdevila; Xiu-Yu Yi; Daniel H Goldman; Christophe Morisseau; Bruce D Hammock; William B Campbell
14,15-Epoxyeicosa-5,8,11-trienoic acid (14,15-EET) surrogates containing epoxide bioisosteres: influence upon vascular relaxation and soluble epoxide hydrolase inhibition.
Journal of medicinal chemistry 2009;52(16):5069-75.
2009: Ketul R Chaudhary; Sri Nagarjun Batchu; Dipankar Das; Mavanur R Suresh; John R Falck; Joan P Graves; Darryl C Zeldin; John M Seubert
Role of B-type natriuretic peptide in epoxyeicosatrienoic acid-mediated improved post-ischaemic recovery of heart contractile function.
Cardiovascular research 2009;83(2):362-70.
2009: Garrett J Gross; Kathryn M Gauthier; Jeannine Moore; William B Campbell; John R Falck; Kasem Nithipatikom
Evidence for role of epoxyeicosatrienoic acids in mediating ischemic preconditioning and postconditioning in dog.
American journal of physiology. Heart and circulatory physiology 2009;297(1):H47-52.
2009: Mukut Sharma; Ellen T McCarthy; D Sudarshan Reddy; Paresh K Patel; Virginia J Savin; Meetha Medhora; John R Falck
8,9-Epoxyeicosatrienoic acid protects the glomerular filtration barrier.
Prostaglandins & other lipid mediators 2009;89(1-2):43-51.
2009: Sreedhar Bodiga; Rong Zhang; Dexter E Jacobs; Brandon T Larsen; Akihito Tampo; Vijay L Manthati; Wai-Meng Kwok; Darryl C Zeldin; John R Falck; David D Gutterman; Elizabeth R Jacobs; Meetha Medhora
Protective actions of epoxyeicosatrienoic acid: dual targeting of cardiovascular PI3K and KATP channels.
Journal of molecular and cellular cardiology 2009;46(6):978-88.
2009: D Katragadda; S N Batchu; Woo Jung Cho; Ketul R Chaudhary; John R Falck; John M Seubert
Epoxyeicosatrienoic acids limit damage to mitochondrial function following stress in cardiac cells.
Journal of molecular and cellular cardiology 2009;46(6):867-75.
2009: Dhurke Kashinath; Charles Mioskowski; John R Falck; Mohan Goli; Stéphane Meunier; Rachid Baati; Alain Wagner
Highly stereoselective synthesis of (Z,E)-1-halo-1,3-dienol esters via rearrangement of Fischer chromium chloro-carbenes using microwave irradiation.
Organic & biomolecular chemistry 2009;7(9):1771-4.
2009: Jingli Wang; James R Schmidt; Richard J Roman; Siddam Anjaiah; John R Falck; Julian H Lombard
Modulation of vascular O2 responses by cytochrome 450-4A omega-hydroxylase metabolites in Dahl salt-sensitive rats.
Microcirculation (New York, N.Y. : 1994) 2009;16(4):345-54.
2009: Anuradha Dhanasekaran; Sreedhar Bodiga; Stephanie K Gruenloh; Ying Gao; Laurel Dunn; John R Falck; J Noelle Buonaccorsi; Meetha Medhora; Elizabeth R Jacobs
20-HETE increases survival and decreases apoptosis in pulmonary arteries and pulmonary artery endothelial cells.
American journal of physiology. Heart and circulatory physiology 2009;296(3):H777-86.
2009: Kevin R Regner; Anna Zuk; Scott K Van Why; Brian D Shames; Robert P Ryan; John R Falck; Vijay L Manthati; Meghan E McMullen; Steven R Ledbetter; Richard J Roman
Protective effect of 20-HETE analogues in experimental renal ischemia reperfusion injury.
Kidney international 2009;75(5):511-7.
2008: Luigi Rodella; Luca Vanella; Stephen J Peterson; George Drummond; Rita Rezzani; John R Falck; Nader G Abraham
Heme oxygenase-derived carbon monoxide restores vascular function in type 1 diabetes.
Drug metabolism letters 2008;2(4):290-300.
2008: Elvira L Liclican; John C McGiff; John R Falck; Mairead A Carroll
Failure to upregulate the adenosine2A receptor-epoxyeicosatrienoic acid pathway contributes to the development of hypertension in Dahl salt-sensitive rats.
American journal of physiology. Renal physiology 2008;295(6):F1696-704.
2008: Benjamin Keserü; Eduardo Barbosa-Sicard; Rüdiger Popp; Beate Fisslthaler; Alexander Dietrich; Thomas Gudermann; Bruce D Hammock; John R Falck; Norbert Weissmann; Rudi Busse; Ingrid Fleming
Epoxyeicosatrienoic acids and the soluble epoxide hydrolase are determinants of pulmonary artery pressure and the acute hypoxic pulmonary vasoconstrictor response.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(12):4306-15.
2008: Mohammed A Nayeem; Samuel M Poloyac; John R Falck; Darryl C Zeldin; Catherine Ledent; Dovenia S Ponnoth; Habib R Ansari; S Jamal Mustafa
Role of CYP epoxygenases in A2A AR-mediated relaxation using A2A AR-null and wild-type mice.
American journal of physiology. Heart and circulatory physiology 2008;295(5):H2068-78.
2008: Yoonjung Park; Stefano Capobianco; Xue Gao; John R Falck; Kevin Dellsperger; Cuihua Zhang
Role of EDHF in type 2 diabetes-induced endothelial dysfunction.
American journal of physiology. Heart and circulatory physiology 2008;295(5):H1982-8.
2008: Anke C Webler; U Ruth Michaelis; Rüdiger Popp; Eduardo Barbosa-Sicard; Andiappan Murugan; John R Falck; Beate Fisslthaler; Ingrid Fleming
Epoxyeicosatrienoic acids are part of the VEGF-activated signaling cascade leading to angiogenesis.
American journal of physiology. Cell physiology 2008;295(5):C1292-301.
2008: Austin Meng Guo; Ju Sheng; GM Scicli; Arbab Ali; Norman Lehman; Paul A Edwards; John R Falck; Richard J Roman; A Guillermo Scicli
Expression of CYP4A1 in U251 human glioma cell induces hyperproliferative phenotype in vitro and rapidly growing tumors in vivo.
The Journal of pharmacology and experimental therapeutics 2008;327(1):10-9.
2008: Jian-Kang Chen; Jianchun Chen; John D Imig; Shouzuo Wei; David L Hachey; Jagadeesh Setti Guthi; John R Falck; Jorge H Capdevila; Raymond C Harris
Identification of novel endogenous cytochrome p450 arachidonate metabolites with high affinity for cannabinoid receptors.
The Journal of biological chemistry 2008;283(36):24514-24.
2008: David Rasko; Cristiano G Moreira; De Run Li; Nicola C Reading; Jennifer M Ritchie; Matthew K Waldor; Noelle Williams; Ron Taussig; Shuguang Wei; Michael Roth; David T Hughes; Jason Huntley; Maggy W Fina; John R Falck; Vanessa Sperandio
Targeting QseC signaling and virulence for antibiotic development.
Science (New York, N.Y.) 2008;321(5892):1078-80.
2008: XIAOGUANG LIU; Chunyuan Li; John R Falck; Richard J Roman; David R Harder; Raymond C Koehler
Interaction of nitric oxide, 20-HETE, and EETs during functional hyperemia in whisker barrel cortex.
American journal of physiology. Heart and circulatory physiology 2008;295(2):H619-31.
2008: Maia Terashvili; Leon F Tseng; Hsiang-En Wu; Jayashree Narayanan; Lucas M Hart; John R Falck; Phillip F Pratt; David R Harder
Antinociception produced by 14,15-epoxyeicosatrienoic acid is mediated by the activation of beta-endorphin and met-enkephalin in the rat ventrolateral periaqueductal gray.
The Journal of pharmacology and experimental therapeutics 2008;326(2):614-22.
2008: Kavita Jain; Anjaiah Siddam; Archana Marathi; Uzzal Roy; John R Falck; Michael Balazy
The mechanism of oleic acid nitration by *NO(2).
Free radical biology & medicine 2008;45(3):269-83.
2008: Houli Jiang; Angela G Zhu; Magdalena Mamczur; Christophe Morisseau; Bruce D Hammock; John R Falck; John C McGiff
Hydrolysis of cis- and trans-epoxyeicosatrienoic acids by rat red blood cells.
The Journal of pharmacology and experimental therapeutics 2008;326(1):330-7.
2008: Garrett J Gross; Kathryn M Gauthier; Jeannine Moore; John R Falck; Bruce D Hammock; William B Campbell; Kasem Nithipatikom
Effects of the selective EET antagonist, 14,15-EEZE, on cardioprotection produced by exogenous or endogenous EETs in the canine heart.
American journal of physiology. Heart and circulatory physiology 2008;294(6):H2838-44.
2008: Dellice J Berezan; Yi Xu; John R Falck; Asish P Kundu; Sandra T Davidge
Ovariectomy, but not estrogen deficiency, increases CYP4A modulation of alpha(1)-adrenergic vasoconstriction in aging female rats.
American journal of hypertension 2008;21(6):685-90.
2008: Zhijian Wang; Yuan Wei; John R Falck; Krishnam Raju Atcha; Wen-Hui Wang
Arachidonic acid inhibits basolateral K channels in the cortical collecting duct via cytochrome P-450 epoxygenase-dependent metabolic pathways.
American journal of physiology. Renal physiology 2008;294(6):F1441-7.
2008: Meetha Medhora; Yuenmu Chen; Stephanie K Gruenloh; Daniel Harland; Sreedhar Bodiga; Jacek Zielonka; Debebe Gebremedhin; Ying Gao; John R Falck; Siddam Anjaiah; Elizabeth R Jacobs
20-HETE increases superoxide production and activates NAPDH oxidase in pulmonary artery endothelial cells.
American journal of physiology. Lung cellular and molecular physiology 2008;294(5):L902-11.
2008: Lijie Cui; Marilyn A Isbell; Yuttana Chawengsub; John R Falck; William B Campbell; Kasem Nithipatikom
Structural characterization of monohydroxyeicosatetraenoic acids and dihydroxy- and trihydroxyeicosatrienoic acids by ESI-FTICR.
Journal of the American Society for Mass Spectrometry 2008;19(4):569-85.
2008: John R Falck; Shuanhu Gao; Ravi Naga Prasad; Sreenivasulu Reddy Koduru
Electrophilic alpha-thiocyanation of chiral and achiral N-acyl imides. A convenient route to 5-substituted and 5,5-disubstituted 2,4-thiazolidinediones.
Bioorganic & medicinal chemistry letters 2008;18(6):1768-71.
2008: Dellice J Berezan; Kathryn M J Dunn; John R Falck; Sandra T Davidge
Aging increases cytochrome P450 4A modulation of alpha1-adrenergic vasoconstriction in mesenteric arteries.
Journal of cardiovascular pharmacology 2008;51(3):327-30.
2008: U Ruth Michaelis; Ning Xia; Eduardo Barbosa-Sicard; John R Falck; Ingrid Fleming
Role of cytochrome P450 2C epoxygenases in hypoxia-induced cell migration and angiogenesis in retinal endothelial cells.
Investigative ophthalmology & visual science 2008;49(3):1242-7.
2008: Kathryn M Gauthier; Yuttana Chawengsub; Daniel H Goldman; Raymond E Conrow; Siddam Anjaiah; John R Falck; William B Campbell
11(R),12(S),15(S)-trihydroxyeicosa-5(Z),8(Z),13(E)-trienoic acid: an endothelium-derived 15-lipoxygenase metabolite that relaxes rabbit aorta.
American journal of physiology. Heart and circulatory physiology 2008;294(3):H1467-72.
2008: Yuttana Chawengsub; Nitin T Aggarwal; Kasem Nithipatikom; Kathryn M Gauthier; Siddam Anjaiah; Bruce D Hammock; John R Falck; William B Campbell
Identification of 15-hydroxy-11,12-epoxyeicosatrienoic acid as a vasoactive 15-lipoxygenase metabolite in rabbit aorta.
American journal of physiology. Heart and circulatory physiology 2008;294(3):H1348-56.
2008: Wenqi Yang; Venugopal Raju Tuniki; Siddam Anjaiah; John R Falck; Cecilia J Hillard; William B Campbell
Characterization of epoxyeicosatrienoic acid binding site in U937 membranes using a novel radiolabeled agonist, 20-125i-14,15-epoxyeicosa-8(Z)-enoic acid.
The Journal of pharmacology and experimental therapeutics 2008;324(3):1019-27.
2008: John D Imig; Christiana Dimitropoulou; D Sudarshan Reddy; Richard E White; John R Falck
Afferent arteriolar dilation to 11, 12-EET analogs involves PP2A activity and Ca2+-activated K+ Channels.
Microcirculation (New York, N.Y. : 1994) 2008;15(2):137-50.
2008: Jennifer Cheng; Jing-Song Ou; Harpreet Singh; John R Falck; Dubasi Narsimhaswamy; Kirkwood A Pritchard; Michal L Schwartzman
20-hydroxyeicosatetraenoic acid causes endothelial dysfunction via eNOS uncoupling.
American journal of physiology. Heart and circulatory physiology 2008;294(2):H1018-26.
2008: Anuradha Dhanasekaran; Stephanie K Gruenloh; J Noelle Buonaccorsi; Rong Zhang; Garrett J Gross; John R Falck; Paresh K Patel; Elizabeth R Jacobs; Meetha Medhora
Multiple antiapoptotic targets of the PI3K/Akt survival pathway are activated by epoxyeicosatrienoic acids to protect cardiomyocytes from hypoxia/anoxia.
American journal of physiology. Heart and circulatory physiology 2008;294(2):H724-35.
2008: De Run Li; Andiappan Murugan; John R Falck
Enantioselective, organocatalytic oxy-michael addition to gamma/delta-hydroxy-alpha,beta-enones: boronate-amine complexes as chiral hydroxide synthons.
Journal of the American Chemical Society 2008;130(1):46-8.
2008: Brandon T Larsen; David D Gutterman; Atsushi Sato; Kazuyoshi Toyama; William B Campbell; Darryl C Zeldin; Vijay L Manthati; John R Falck; Hiroto Miura
Hydrogen peroxide inhibits cytochrome p450 epoxygenases: interaction between two endothelium-derived hyperpolarizing factors.
Circulation research 2008;102(1):59-67.
2008: Biao Lu; John R Falck
Efficient iridium-catalyzed C-H functionalization/silylation of heteroarenes.
Angewandte Chemie (International ed. in English) 2008;47(39):7508-10.
2008: Anyu He; John R Falck
Synthesis of enantioenriched alpha-(hydroxyalkyl)-tri-n-butylstannanes.
Angewandte Chemie (International ed. in English) 2008;47(35):6586-9.
2008: Jing Li; Mairead A Carroll; Praveen N Chander; John R Falck; Bhavani Sangras; Charles T Stier
Soluble epoxide hydrolase inhibitor, AUDA, prevents early salt-sensitive hypertension.
Frontiers in bioscience : a journal and virtual library 2008;13():3480-7.
2008: Tsuneo Ishizuka; Jennifer Cheng; Harpreet Singh; Marco D Vitto; Vijay L Manthati; John R Falck; Michal Laniado-Schwartzman
20-Hydroxyeicosatetraenoic acid stimulates nuclear factor-kappaB activation and the production of inflammatory cytokines in human endothelial cells.
The Journal of pharmacology and experimental therapeutics 2008;324(1):103-10.
2008: Yanrong Shi; XIAOGUANG LIU; Debebe Gebremedhin; John R Falck; David R Harder; Raymond C Koehler
Interaction of mechanisms involving epoxyeicosatrienoic acids, adenosine receptors, and metabotropic glutamate receptors in neurovascular coupling in rat whisker barrel cortex.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2008;28(1):111-25.
2007: Christopher Illies; Jesper Gromada; Roberta Fiume; Barbara Leibiger; Jia Yu; Kirstine Juhl; Shao-Nian Yang; Deb K Barma; John R Falck; Adolfo Saiardi; Christopher J Barker; Per-Olof Berggren
Requirement of inositol pyrophosphates for full exocytotic capacity in pancreatic beta cells.
Science (New York, N.Y.) 2007;318(5854):1299-302.
2007: Cecilia J Hillard; Leyu Shi; Venugopal Raju Tuniki; John R Falck; William B Campbell
Studies of anandamide accumulation inhibitors in cerebellar granule neurons: comparison to inhibition of fatty acid amide hydrolase.
Journal of molecular neuroscience : MN 2007;33(1):18-24.
2007: Jorge H Capdevila; John R Falck; J D Imig
Roles of the cytochrome P450 arachidonic acid monooxygenases in the control of systemic blood pressure and experimental hypertension.
Kidney international 2007;72(6):683-9.
2007: Michael P Endsley; Nitin Aggarwal; Marilyn A Isbell; Craig E Wheelock; Bruce D Hammock; John R Falck; William B Campbell; Kasem Nithipatikom
Diverse roles of 2-arachidonoylglycerol in invasion of prostate carcinoma cells: Location, hydrolysis and 12-lipoxygenase metabolism.
International journal of cancer. Journal international du cancer 2007;121(5):984-91.
2007: Houli Jiang; A G Zhu; M Mamczur; John R Falck; Kenneth M Lerea; John C McGiff
Stimulation of rat erythrocyte P2X7 receptor induces the release of epoxyeicosatrienoic acids.
British journal of pharmacology 2007;151(7):1033-40.
2007: Jan Michael Williams; Mukut Sharma; Siddam Anjaiahh; John R Falck; Richard J Roman
Role of endogenous CYP450 metabolites of arachidonic acid in maintaining the glomerular protein permeability barrier.
American journal of physiology. Renal physiology 2007;293(2):F501-5.
2007: David X Zhang; Kathryn M Gauthier; John R Falck; Anjaiah Siddam; William B Campbell
Steroid-producing cells regulate arterial tone of adrenal cortical arteries.
Endocrinology 2007;148(8):3569-76.
2007: Hui Huang; Christophe Morisseau; JingFeng Wang; Tianxin Yang; John R Falck; Bruce D Hammock; Mong-Heng Wang
Increasing or stabilizing renal epoxyeicosatrienoic acid production attenuates abnormal renal function and hypertension in obese rats.
American journal of physiology. Renal physiology 2007;293(1):F342-9.
2007: Valerie Y Ng; Yong Huang; L Manmohan Reddy; John R Falck; Emil T Lin; Deanna L Kroetz
Cytochrome P450 eicosanoids are activators of peroxisome proliferator-activated receptor alpha.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(7):1126-34.
2007: Ambra Pozzi; Maria Raquel Ibanez; Arnaldo E Gatica; Shilin Yang; Shouzuo Wei; Shaojun Mei; John R Falck; Jorge H Capdevila
Peroxisomal proliferator-activated receptor-alpha-dependent inhibition of endothelial cell proliferation and tumorigenesis.
The Journal of biological chemistry 2007;282(24):17685-95.
2007: Wenqi Yang; Blythe B Holmes; Renju Gopal; R V Krishna Kishore; Bhavani Sangras; Xiu-Yu Yi; John R Falck; William B Campbell
Characterization of 14,15-epoxyeicosatrienoyl-sulfonamides as 14,15-epoxyeicosatrienoic acid agonists: use for studies of metabolism and ligand binding.
The Journal of pharmacology and experimental therapeutics 2007;321(3):1023-31.
2007: Ming Yu; Bernardo Lopez; Elisabete Forsberg; John R Falck; Richard J Roman
Effects of 20-HETE on Na+ transport and Na+ -K+ -ATPase activity in the thick ascending loop of Henle.
American journal of physiology. Regulatory, integrative and comparative physiology 2007;292(6):R2400-5.
2007: John R Falck; L Manmohan Reddy; Kihwan Byun; William B Campbell; Xiu-Yu Yi
Epoxygenase eicosanoids: synthesis of tetrahydrofuran-diol metabolites and their vasoactivity.
Bioorganic & medicinal chemistry letters 2007;17(9):2634-8.
2007: Yue Chen; Robert W. Sprung; Yi Tang; Haydn Ball; Bhavani Sangras; Sung Chan Kim; John R Falck; Junmin Peng; Wei Gu; Yingming Zhao
Lysine propionylation and butyrylation are novel post-translational modifications in histones.
Molecular & cellular proteomics : MCP 2007;6(5):812-9.
2007: Xiu-Yu Yi; Kathryn M Gauthier; Lijie Cui; Kasem Nithipatikom; John R Falck; William B Campbell
Metabolism of adrenic acid to vasodilatory 1alpha,1beta-dihomo-epoxyeicosatrienoic acids by bovine coronary arteries.
American journal of physiology. Heart and circulatory physiology 2007;292(5):H2265-74.
2007: Jianchun Chen; Jian-Kang Chen; John R Falck; Jagadeesh Setti Guthi; Siddam Anjaiah; Jorge H Capdevila; Raymond C Harris
Mitogenic activity and signaling mechanism of 2-(14,15- epoxyeicosatrienoyl)glycerol, a novel cytochrome p450 arachidonate metabolite.
Molecular and cellular biology 2007;27(8):3023-34.
2007: Garrett J Gross; Anna Hsu; John R Falck; Kasem Nithipatikom
Mechanisms by which epoxyeicosatrienoic acids (EETs) elicit cardioprotection in rat hearts.
Journal of molecular and cellular cardiology 2007;42(3):687-91.
2007: William B Campbell; John R Falck
Arachidonic acid metabolites as endothelium-derived hyperpolarizing factors.
Hypertension 2007;49(3):590-6.
2007: Christiana Dimitropoulou; Lashondra West; Mary B Field; Richard E White; L Manmohan Reddy; John R Falck; John D Imig
Protein phosphatase 2A and Ca2+-activated K+ channels contribute to 11,12-epoxyeicosatrienoic acid analog mediated mesenteric arterial relaxation.
Prostaglandins & other lipid mediators 2007;83(1-2):50-61.
2007: John R Falck; Paresh K Patel; Anish Bandyopadhyay
Stereospecific cross-coupling of alpha-(thiocarbamoyl)organostannanes with alkenyl, aryl, and heteroaryl iodides.
Journal of the American Chemical Society 2007;129(4):790-3.
2007: John R Falck; Bhavani Sangras; Jorge H Capdevila
Preparation of N-tBoc L-glutathione dimethyl and di-tert-butyl esters: versatile synthetic building blocks.
Bioorganic & medicinal chemistry 2007;15(2):1062-6.
2007: Romain Bejot; Anyu He; John R Falck; Charles Mioskowski
Chromium-carbyne complexes: intermediates for organic synthesis.
Angewandte Chemie (International ed. in English) 2007;46(10):1719-22.
2007: Xiang Fang; Joseph S Dillon; Shanming Hu; Shawn D Harmon; Jianrong Yao; Siddam Anjaiah; John R Falck; Arthur A Spector
20-carboxy-arachidonic acid is a dual activator of peroxisome proliferator-activated receptors alpha and gamma.
Prostaglandins & other lipid mediators 2007;82(1-4):175-84.
2007: Meetha Medhora; Anuradha Dhanasekaran; Stephanie K Gruenloh; Laurel K Dunn; Michael Gabrilovich; John R Falck; David R Harder; Elizabeth R Jacobs; Phillip F Pratt
Emerging mechanisms for growth and protection of the vasculature by cytochrome P450-derived products of arachidonic acid and other eicosanoids.
Prostaglandins & other lipid mediators 2007;82(1-4):19-29.
2006: Hui Huang; Hsin-Hsin Chang; Yue Xu; D Sudarshan Reddy; Juan Du; Yiqiang Zhou; Zheng Dong; John R Falck; Mong-Heng Wang
Epoxyeicosatrienoic Acid inhibition alters renal hemodynamics during pregnancy.
Experimental biology and medicine (Maywood, N.J.) 2006;231(11):1744-52.
2006: Valerie Y Ng; Christophe Morisseau; John R Falck; Bruce D Hammock; Deanna L Kroetz
Inhibition of smooth muscle proliferation by urea-based alkanoic acids via peroxisome proliferator-activated receptor alpha-dependent repression of cyclin D1.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(11):2462-8.
2006: Xiang Fang; Frank M Faraci; Terry L Kaduce; Shawn D Harmon; Mary L Modrick; Shanming Hu; Steven A Moore; John R Falck; Neal L Weintraub; Arthur A Spector
20-Hydroxyeicosatetraenoic acid is a potent dilator of mouse basilar artery: role of cyclooxygenase.
American journal of physiology. Heart and circulatory physiology 2006;291(5):H2301-7.
2006: John R Falck; Romain Bejot; Deb K Barma; Anish Bandyopadhyay; Suju Joseph; Charles Mioskowski
Fe(0)-mediated synthesis of tri- and tetra-substituted olefins from carbonyls: an environmentally friendly alternative to Cr(II).
The Journal of organic chemistry 2006;71(21):8178-82.
2006: John R Falck; Anyu He; L Manmohan Reddy; Abhijit Kundu; Deb K Barma; Anish Bandyopadhyay; SUKANTA KAMILA; Radha Akella; Romain Bejot; Charles Mioskowski
Ring expansion/homologation--aldehyde condensation cascade using tert-trihalomethylcarbinols.
Organic letters 2006;8(20):4645-7.
2006: Shawn D Harmon; Xiang Fang; Terry L Kaduce; Shanming Hu; V Raj Gopal; John R Falck; Arthur A Spector
Oxygenation of omega-3 fatty acids by human cytochrome P450 4F3B: effect on 20-hydroxyeicosatetraenoic acid production.
Prostaglandins, leukotrienes, and essential fatty acids 2006;75(3):169-77.
2006: Yuenmu Chen; Meetha Medhora; John R Falck; Kirkwood A Pritchard; Elizabeth R Jacobs
Mechanisms of activation of eNOS by 20-HETE and VEGF in bovine pulmonary artery endothelial cells.
American journal of physiology. Lung cellular and molecular physiology 2006;291(3):L378-85.
2006: Kasem Nithipatikom; Jeannine M Moore; Marilyn A Isbell; John R Falck; Garrett J Gross
Epoxyeicosatrienoic acids in cardioprotection: ischemic versus reperfusion injury.
American journal of physiology. Heart and circulatory physiology 2006;291(2):H537-42.
2006: Rachid Baati; Charles Mioskowski; Deb K Barma; Rajashaker Kache; John R Falck
Reductive olefination of aldehydes via chromium Brook rearrangement.
Organic letters 2006;8(14):2949-51.
2006: Mairead A Carroll; Anabel B Doumad; Jing Li; Monica K Cheng; John R Falck; John C McGiff
Adenosine2A receptor vasodilation of rat preglomerular microvessels is mediated by EETs that activate the cAMP/PKA pathway.
American journal of physiology. Renal physiology 2006;291(1):F155-61.
2006: Luigi Rodella; Brian D Lamon; Rita Rezzani; Bhavani Sangras; Alvin I Goodman; John R Falck; Nader G Abraham
Carbon monoxide and biliverdin prevent endothelial cell sloughing in rats with type I diabetes.
Free radical biology & medicine 2006;40(12):2198-205.
2006: Kiyoshi Nakagawa; Vijaykumar R Holla; Yuan Wei; Wen-Hui Wang; Arnaldo Gatica; Shouzou Wei; Shaojun Mei; Crystal M Miller; Dae Ryong Cha; Edward Price; Roy Zent; Ambra Pozzi; Matthew D Breyer; Youfei Guan; John R Falck; Michael R Waterman; Jorge H Capdevila
Salt-sensitive hypertension is associated with dysfunctional Cyp4a10 gene and kidney epithelial sodium channel.
The Journal of clinical investigation 2006;116(6):1696-702.
2006: Shouzou Wei; James J Brittin; John R Falck; Siddam Anjaiah; Kasem Nithipatikom; Lijie Cui; William B Campbell; Jorge H Capdevila
Chiral resolution of the epoxyeicosatrienoic acids, arachidonic acid epoxygenase metabolites.
Analytical biochemistry 2006;352(1):129-34.
2006: Dan Ye; Wei Zhou; Tong Lu; Jagadeesh Setti Guthi; John R Falck; Hon-Chi Lee
Mechanism of rat mesenteric arterial KATP channel activation by 14,15-epoxyeicosatrienoic acid.
American journal of physiology. Heart and circulatory physiology 2006;290(4):H1326-36.
2006: Liming Jin; Clare E Foss; Xueying _ Zhao; Thomas M Mills; Mong-Heng Wang; Lynnette McCluskey; Ganesh S S Yaddanapud; John R Falck; John D Imig; R Clinton Webb
Cytochrome P450 epoxygenases provide a novel mechanism for penile erection.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(3):539-41.
2006: Brandon T Larsen; Hiroto Miura; Ossama A Hatoum; William B Campbell; Bruce D Hammock; Darryl C Zeldin; John R Falck; David D Gutterman
Epoxyeicosatrienoic and dihydroxyeicosatrienoic acids dilate human coronary arterioles via BK(Ca) channels: implications for soluble epoxide hydrolase inhibition.
American journal of physiology. Heart and circulatory physiology 2006;290(2):H491-9.
2006: Kasem Nithipatikom; Michael P Endsley; Jeannine M Moore; Marilyn A Isbell; John R Falck; William B Campbell; Garrett J Gross
Effects of selective inhibition of cytochrome P-450 omega-hydroxylases and ischemic preconditioning in myocardial protection.
American journal of physiology. Heart and circulatory physiology 2006;290(2):H500-5.
2006: Animesh Nandi; Robert W. Sprung; Deb K Barma; Yingxin Zhao; Sung Chan Kim; John R Falck; Yingming Zhao
Global identification of O-GlcNAc-modified proteins.
Analytical chemistry 2006;78(2):452-8.
2006: Sung Chan Kim; Yoonjung Kho; Deb K Barma; John R Falck; Yingming Zhao
A tagging-via-substrate technology for genome-wide detection and identification of farnesylated proteins.
Methods in enzymology 2006;407():629-37.
2006: Liping Du; Valery Yermalitsky; David L Hachey; Jagadeesh Setti Guthi; John R Falck; Diane S Keeney
A biosynthetic pathway generating 12-hydroxy-5,8,14-eicosatrienoic acid from arachidonic acid is active in mouse skin microsomes.
The Journal of pharmacology and experimental therapeutics 2006;316(1):371-9.
2006: William B Campbell; Blythe B Holmes; John R Falck; Jorge H Capdevila; Kathryn M Gauthier
Regulation of potassium channels in coronary smooth muscle by adenoviral expression of cytochrome P-450 epoxygenase.
American journal of physiology. Heart and circulatory physiology 2006;290(1):H64-71.
2006: Xiang Fang; Shanming Hu; Bingkun Xu; Gary D Snyder; Shawn D Harmon; Jianrong Yao; Yi Liu; Bhavani Sangras; John R Falck; Neal L Weintraub; Arthur A Spector
14,15-Dihydroxyeicosatrienoic acid activates peroxisome proliferator-activated receptor-alpha.
American journal of physiology. Heart and circulatory physiology 2006;290(1):H55-63.
2006: Xin Tang; Erik M Edwards; Blythe B Holmes; John R Falck; William B Campbell
Role of phospholipase C and diacylglyceride lipase pathway in arachidonic acid release and acetylcholine-induced vascular relaxation in rabbit aorta.
American journal of physiology. Heart and circulatory physiology 2006;290(1):H37-45.
2005: Hui Huang; Yiqiang Zhou; Venugopal T Raju; Juan Du; Hsin-Hsin Chang; Cong-Yi Wang; Michael W Brands; John R Falck; Mong-Heng Wang
Renal 20-HETE inhibition attenuates changes in renal hemodynamics induced by L-NAME treatment in pregnant rats.
American journal of physiology. Renal physiology 2005;289(5):F1116-22.
2005: Alexandre Mezentsev; Vladimir Mastyugin; Francesca Seta; Silvia Ashkar; Rowena Kemp; D Sudarshan Reddy; John R Falck; Michael W Dunn; Michal Laniado-Schwartzman
Transfection of cytochrome P4504B1 into the cornea increases angiogenic activity of the limbal vessels.
The Journal of pharmacology and experimental therapeutics 2005;315(1):42-50.
2005: Garrett J Gross; John R Falck; Eric R Gross; Marilyn A Isbell; Jeannine Moore; Kasem Nithipatikom
Cytochrome P450 and arachidonic acid metabolites: role in myocardial ischemia/reperfusion injury revisited.
Cardiovascular research 2005;68(1):18-25.
2005: Xixuan H Collins; Shawn D Harmon; Terry L Kaduce; Kristine B Berst; Xiang Fang; Steven A Moore; T Verugopal Raju; John R Falck; Neal L Weintraub; Gregg Duester; Bryce V Plapp; Arthur A Spector
Omega-oxidation of 20-hydroxyeicosatetraenoic acid (20-HETE) in cerebral microvascular smooth muscle and endothelium by alcohol dehydrogenase 4.
The Journal of biological chemistry 2005;280(39):33157-64.
2005: An Huang; Dong Sun; Changdong Yan; John R Falck; Gabor Kaley
Contribution of 20-HETE to augmented myogenic constriction in coronary arteries of endothelial NO synthase knockout mice.
Hypertension 2005;46(3):607-13.
2005: Laurel K Dunn; Stephanie K Gruenloh; Bruce E Dunn; D Sudarshan Reddy; John R Falck; Elizabeth R Jacobs; Meetha Medhora
Chick chorioallantoic membrane as an in vivo model to study vasoreactivity: characterization of development-dependent hyperemia induced by epoxyeicosatrienoic acids (EETs).
The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology 2005;285(2):771-80.
2005: Elvira L Liclican; John C McGiff; Paulina L Pedraza; Nicholas R Ferreri; John R Falck; Mairead A Carroll
Exaggerated response to adenosine in kidneys from high salt-fed rats: role of epoxyeicosatrienoic acids.
American journal of physiology. Renal physiology 2005;289(2):F386-92.
2005: Ambra Pozzi; Ines Macias-Perez; Tristin Abair; Shouzuo Wei; Yan Su; Roy Zent; John R Falck; Jorge H Capdevila
Characterization of 5,6- and 8,9-epoxyeicosatrienoic acids (5,6- and 8,9-EET) as potent in vivo angiogenic lipids.
The Journal of biological chemistry 2005;280(29):27138-46.
2005: Ines Drenjancevic-Peric; Shane Phillips; John R Falck; Julian H Lombard
Restoration of normal vascular relaxation mechanisms in cerebral arteries by chromosomal substitution in consomic SS.13BN rats.
American journal of physiology. Heart and circulatory physiology 2005;289(1):H188-95.
2005: Robert W. Sprung; Animesh Nandi; Yue Chen; Sung Chan Kim; Deb K Barma; John R Falck; Yingming Zhao
Tagging-via-substrate strategy for probing O-GlcNAc modified proteins.
Journal of proteome research 2005;4(3):950-7.
2005: Giovanni Li Volti; David Sacerdoti; Bhavani Sangras; Angelo Vanella; Alexandre Mezentsev; giovanni scapagnini; John R Falck; Nader G Abraham
Carbon monoxide signaling in promoting angiogenesis in human microvessel endothelial cells.
Antioxidants & redox signaling 2005;7(5-6):704-10.
2005: Kathryn M Gauthier; Erik M Edwards; John R Falck; D Sudarshan Reddy; William B Campbell
14,15-epoxyeicosatrienoic acid represents a transferable endothelium-dependent relaxing factor in bovine coronary arteries.
Hypertension 2005;45(4):666-71.
2005: Wenqi Yang; Kathryn M Gauthier; L Manmohan Reddy; Bhavani Sangras; Kamalesh K Sharma; Kasem Nithipatikom; John R Falck; William B Campbell
Stable 5,6-epoxyeicosatrienoic acid analog relaxes coronary arteries through potassium channel activation.
Hypertension 2005;45(4):681-6.
2005: Jingli Wang; Richard J Roman; John R Falck; Lourdes de la Cruz; Julian H Lombard
Effects of high-salt diet on CYP450-4A omega-hydroxylase expression and active tone in mesenteric resistance arteries.
American journal of physiology. Heart and circulatory physiology 2005;288(4):H1557-65.
2005: Bin Zhao; F Peter Guengerich; Aouatef Bellamine; David C Lamb; Miho Izumikawa; Li Lei; Larissa M Podust; Munirathinam Sundaramoorthy; John A Kalaitzis; L Manmohan Reddy; Steven L Kelly; Bradley S Moore; Donald F Stec; Markus Voehler; John R Falck; Tsutomu Shimada; Michael R Waterman
Binding of two flaviolin substrate molecules, oxidative coupling, and crystal structure of Streptomyces coelicolor A3(2) cytochrome P450 158A2.
The Journal of biological chemistry 2005;280(12):11599-607.
2005: Romain Bejot; Steve Tisserand; L Manmohan Reddy; Deb K Barma; Rachid Baati; John R Falck; Charles Mioskowski
Stereoselective transformations of trihalomethylcarbinols induced by chromous chloride.
Angewandte Chemie (International ed. in English) 2005;44(13):2008-11.
2005: Kathryn M Gauthier; David V Baewer; Sarah Hittner; Cecilia J Hillard; Kasem Nithipatikom; D Sudarshan Reddy; John R Falck; William B Campbell
Endothelium-derived 2-arachidonylglycerol: an intermediate in vasodilatory eicosanoid release in bovine coronary arteries.
American journal of physiology. Heart and circulatory physiology 2005;288(3):H1344-51.
2005: An Huang; Dong Sun; Azita Jacobson; Mairead A Carroll; John R Falck; Gabor Kaley
Epoxyeicosatrienoic acids are released to mediate shear stress-dependent hyperpolarization of arteriolar smooth muscle.
Circulation research 2005;96(3):376-83.
2005: Sachin Patel; Erica J. Carrier; W-S Vanessa Ho; David J Rademacher; Sonya Cunningham; D Sudarshan Reddy; John R Falck; Benjamin F Cravatt; Cecilia J Hillard
The postmortal accumulation of brain N-arachidonylethanolamine (anandamide) is dependent upon fatty acid amide hydrolase activity.
Journal of lipid research 2005;46(2):342-9.
2005: Houli Jiang; John Quilley; L Manmohan Reddy; John R Falck; Patrick Y K Wong; John C McGiff
Red blood cells: reservoirs of cis- and trans-epoxyeicosatrienoic acids.
Prostaglandins & other lipid mediators 2005;75(1-4):65-78.
2005: Fan Zhang; Huan Deng; Rowena Kemp; Harpreet Singh; Renju Gopal; John R Falck; Michal Laniado-Schwartzman; Alberto Nasjletti
Decreased levels of cytochrome P450 2E1-derived eicosanoids sensitize renal arteries to constrictor agonists in spontaneously hypertensive rats.
Hypertension 2005;45(1):103-8.
2004: Kasem Nithipatikom; Michael P Endsley; Marilyn A Isbell; John R Falck; Yoshiki Iwamoto; Cecilia J Hillard; William B Campbell
2-arachidonoylglycerol: a novel inhibitor of androgen-independent prostate cancer cell invasion.
Cancer research 2004;64(24):8826-30.
2004: Eric R Gross; Kasem Nithipatikom; Anna K Hsu; Jason N Peart; John R Falck; William B Campbell; Garrett J Gross
Cytochrome P450 omega-hydroxylase inhibition reduces infarct size during reperfusion via the sarcolemmal KATP channel.
Journal of molecular and cellular cardiology 2004;37(6):1245-9.
2004: Yuan Wei; Dao-Hong Lin; Rowena Kemp; Ganesh S S Yaddanapudi; Alberto Nasjletti; John R Falck; Wen-Hui Wang
Arachidonic acid inhibits epithelial Na channel via cytochrome P450 (CYP) epoxygenase-dependent metabolic pathways.
The Journal of general physiology 2004;124(6):719-27.
2004: Xueying _ Zhao; John R Falck; Renju Gopal; Edward Inscho; John D Imig
P2X receptor-stimulated calcium responses in preglomerular vascular smooth muscle cells involves 20-hydroxyeicosatetraenoic acid.
The Journal of pharmacology and experimental therapeutics 2004;311(3):1211-7.
2004: Kasem Nithipatikom; Eric R Gross; Michael P Endsley; Jeannine M Moore; Marilyn A Isbell; John R Falck; William B Campbell; Garrett J Gross
Inhibition of cytochrome P450omega-hydroxylase: a novel endogenous cardioprotective pathway.
Circulation research 2004;95(8):e65-71.
2004: John R Falck; Deb K Barma; Suchismita Mohapatra; Anish Bandyopadhyay; Komandla Malla Reddy; Jianjun Qi; William B Campbell
Asymmetric synthesis of the stereoisomers of 11,12,15(S)-trihydroxyeicosa-5(Z),8(Z),13(E)-trienoic acid, a potent endothelium-derived vasodilator.
Bioorganic & medicinal chemistry letters 2004;14(19):4987-90.
2004: Chaza M Zghibeh; V Raj Gopal; Candace D Poff; John R Falck; Michael Balazy
Determination of trans-arachidonic acid isomers in human blood plasma.
Analytical biochemistry 2004;332(1):137-44.
2004: Fan Zhang; Mong-Heng Wang; Ji-Shi Wang; Barbara A Zand; Renju Gopal; John R Falck; Michal Laniado-Schwartzman; Alberto Nasjletti
Transfection of CYP4A1 cDNA decreases diameter and increases responsiveness of gracilis muscle arterioles to constrictor stimuli.
American journal of physiology. Heart and circulatory physiology 2004;287(3):H1089-95.
2004: Houli Jiang; John C McGiff; John Quilley; David Sacerdoti; L Manmohan Reddy; John R Falck; Fan Zhang; Kenneth M Lerea; Patrick Y-K Wong
Identification of 5,6-trans-epoxyeicosatrienoic acid in the phospholipids of red blood cells.
The Journal of biological chemistry 2004;279(35):36412-8.
2004: Yoonjung Kho; Sung Chan Kim; Chen Jiang; Deb K Barma; Sung Won Kwon; Jinke Cheng; Janis Jaunbergs; Carolyn Weinbaum; Fuyuhiko Tamanoi; John R Falck; Yingming Zhao
A tagging-via-substrate technology for detection and proteomics of farnesylated proteins.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(34):12479-84.
2004: Jun-Ichi Kaide; Fan Zhang; Yuan Wei; WenHui Wang; Renju Gopal; John R Falck; Michal Laniado-Schwartzman; Alberto Nasjletti
Vascular CO counterbalances the sensitizing influence of 20-HETE on agonist-induced vasoconstriction.
Hypertension 2004;44(2):210-6.
2004: Kathryn M Gauthier; John R Falck; L Manmohan Reddy; William B Campbell
14,15-EET analogs: characterization of structural requirements for agonist and antagonist activity in bovine coronary arteries.
Pharmacological research : the official journal of the Italian Pharmacological Society 2004;49(6):515-24.
2004: Fengyun Xu; John R Falck; Paul R. Ortiz de Montellano; Deanna L Kroetz
Catalytic activity and isoform-specific inhibition of rat cytochrome p450 4F enzymes.
The Journal of pharmacology and experimental therapeutics 2004;308(3):887-95.
2004: Ming Yu; Liana Cambj-Sapunar; Franz Kehl; Kristopher G Maier; Kazuhiko Takeuchi; Noriyuki Miyata; Tsuyoshi Ishimoto; L Manmohan Reddy; John R Falck; Debebe Gebremedhin; David R Harder; Richard J Roman
Effects of a 20-HETE antagonist and agonists on cerebral vascular tone.
European journal of pharmacology 2004;486(3):297-306.
2004: Miao Jiang; Alexandre Mezentsev; Rowena Kemp; Kihwan Byun; John R Falck; Joseph M Miano; Alberto Nasjletti; Nader G Abraham; Michal Laniado-Schwartzman
Smooth muscle--specific expression of CYP4A1 induces endothelial sprouting in renal arterial microvessels.
Circulation research 2004;94(2):167-74.
2004: An Huang; Dong Sun; Zhiping Wu; Changdong Yan; Mairead A Carroll; Houli Jiang; John R Falck; Gabor Kaley
Estrogen elicits cytochrome P450--mediated flow-induced dilation of arterioles in NO deficiency: role of PI3K-Akt phosphorylation in genomic regulation.
Circulation research 2004;94(2):245-52.
2004: Monica K Cheng; Anabel B Doumad; Houli Jiang; John R Falck; John C McGiff; Mairead A Carroll
Epoxyeicosatrienoic acids mediate adenosine-induced vasodilation in rat preglomerular microvessels (PGMV) via A2A receptors.
British journal of pharmacology 2004;141(3):441-8.
2004: Terry L Kaduce; Xiang Fang; Shawn D Harmon; Christine L Oltman; Kevin Dellsperger; Lynn M Teesch; Renju Gopal; John R Falck; William B Campbell; Neal L Weintraub; Arthur A Spector
20-hydroxyeicosatetraenoic acid (20-HETE) metabolism in coronary endothelial cells.
The Journal of biological chemistry 2004;279(4):2648-56.
2004: Julian H Lombard; Jefferson C Frisbee; Richard J Roman; John R Falck
Evaluation of cytochrome P450-4A omega-hydroxylase and 20-hydroxyeicosatetraenoic acid as an O2 sensing mechanism in the microcirculation.
Methods in enzymology 2004;381():140-65.
2003: Suchismita Mohapatra; Anish Bandyopadhyay; Deb K Barma; Jorge H Capdevila; John R Falck
Chiral alpha,beta-dialkoxy- and alpha-alkoxy-beta-aminostannanes: preparation and copper-mediated cross-coupling.
Organic letters 2003;5(25):4759-62.
2003: Deb K Barma; Anish Bandyopadhyay; Jorge H Capdevila; John R Falck
Dimethylthiocarbamate (DMTC): an alcohol protecting group.
Organic letters 2003;5(25):4755-7.
2003: John R Falck; L Manmohan Reddy; Y Krishna Reddy; Muralidhar Bondlela; U Murali Krishna; Yu Ji; Jianxin Sun; James K Liao
11,12-epoxyeicosatrienoic acid (11,12-EET): structural determinants for inhibition of TNF-alpha-induced VCAM-1 expression.
Bioorganic & medicinal chemistry letters 2003;13(22):4011-4.
2003: Y Krishna Reddy; L Manmohan Reddy; Jorge H Capdevila; John R Falck
Practical, asymmetric synthesis of 16-hydroxyeicosa-5(Z),8(Z), 11(Z),14(Z)-tetraenoic acid (16-HETE), an endogenous inhibitor of neutrophil activity.
Bioorganic & medicinal chemistry letters 2003;13(21):3719-20.
2003: Kathryn M Gauthier; Jagadeesh Setti Guthi; John R Falck; William B Campbell
14,15-epoxyeicosa-5(Z)-enoic-mSI: a 14,15- and 5,6-EET antagonist in bovine coronary arteries.
Hypertension 2003;42(4):555-61.
2003: Silvia I Pomposiello; John Quilley; Mairead A Carroll; John R Falck; John C McGiff
5,6-epoxyeicosatrienoic acid mediates the enhanced renal vasodilation to arachidonic acid in the SHR.
Hypertension 2003;42(4):548-54.
2003: Ming Yu; Magdalena Alonso-Galicia; Cheng-Wen Sun; Richard J Roman; Naoya Ono; Hitomi Hirano; Tsuyoshi Ishimoto; Y Krishna Reddy; Kishta Reddy Katipally; Komandla Malla Reddy; Renju Gopal; Ji Yu; Mohamed Takhi; John R Falck
20-hydroxyeicosatetraenoic acid (20-HETE): structural determinants for renal vasoconstriction.
Bioorganic & medicinal chemistry 2003;11(13):2803-21.
2003: Sachin Patel; Eric R Wohlfeil; David J Rademacher; Erica J. Carrier; LaToya J Perry; Abhijit Kundu; John R Falck; Kasem Nithipatikom; William B Campbell; Cecilia J Hillard
The general anesthetic propofol increases brain N-arachidonylethanolamine (anandamide) content and inhibits fatty acid amide hydrolase.
British journal of pharmacology 2003;139(5):1005-13.
2003: Sandra L Pfister; Nancy Spitzbarth; Kasem Nithipatikom; John R Falck; William B Campbell
Metabolism of 12-hydroperoxyeicosatetraenoic acid to vasodilatory trioxilin C3 by rabbit aorta.
Biochimica et biophysica acta 2003;1622(1):6-13.
2003: Deb K Barma; Anissa N Elayadi; John R Falck; David R Corey
Inhibition of telomerase by BIBR 1532 and related analogues.
Bioorganic & medicinal chemistry letters 2003;13(7):1333-6.
2003: Sung Won Kwon; Sung Chan Kim; Janis Jaunbergs; John R Falck; Yingming Zhao
Selective enrichment of thiophosphorylated polypeptides as a tool for the analysis of protein phosphorylation.
Molecular & cellular proteomics : MCP 2003;2(4):242-7.
2003: Deb K Barma; Abhijit Kundu; Hongming Zhang; Charles Mioskowski; John R Falck
(Z)-alpha-haloacrylates: an exceptionally stereoselective preparation via Cr(II)-mediated olefination of aldehydes with trihaloacetates.
Journal of the American Chemical Society 2003;125(11):3218-9.
2003: Jun-Ichi Kaide; Mong-Heng Wang; Ji-Shi Wang; Fan Zhang; Renju Gopal; John R Falck; Alberto Nasjletti; Michal Laniado-Schwartzman
Transfection of CYP4A1 cDNA increases vascular reactivity in renal interlobar arteries.
American journal of physiology. Renal physiology 2003;284(1):F51-6.
2003: John R Falck; U Murali Krishna; Y Krishna Reddy; P Srinagesh Kumar; Komandla Malla Reddy; Sarah B Hittner; Christine Deeter; Kamalesh K Sharma; Kathryn M Gauthier; William B Campbell
Comparison of vasodilatory properties of 14,15-EET analogs: structural requirements for dilation.
American journal of physiology. Heart and circulatory physiology 2003;284(1):H337-49.
2002: Gary D Snyder; U Murali Krishna; John R Falck; Arthur A Spector
Evidence for a membrane site of action for 14,15-EET on expression of aromatase in vascular smooth muscle.
American journal of physiology. Heart and circulatory physiology 2002;283(5):H1936-42.
2002: L Ashley Cowart; Shouzuo Wei; Mei-Hui Hsu; Eric F Johnson; Murali U Krishna; John R Falck; Jorge H Capdevila
The CYP4A isoforms hydroxylate epoxyeicosatrienoic acids to form high affinity peroxisome proliferator-activated receptor ligands.
The Journal of biological chemistry 2002;277(38):35105-12.
2002: Robin C Looft-Wilson; John R Falck; U Murali Krishna; Carl V Gisolfi
20-HETE pathway antagonists inhibit rat small mesenteric artery tone.
Microvascular research 2002;64(2):349-352.
2002: Jorge H Capdevila; John R Falck
Biochemical and molecular properties of the cytochrome P450 arachidonic acid monooxygenases.
Prostaglandins & other lipid mediators 2002;68-69():325-44.
2002: Jefferson C Frisbee; Kristopher G Maier; John R Falck; Richard J Roman; Julian H Lombard
Integration of hypoxic dilation signaling pathways for skeletal muscle resistance arteries.
American journal of physiology. Regulatory, integrative and comparative physiology 2002;283(2):R309-19.
2002: Alexandre Mezentsev; Francesca Seta; Michael W Dunn; Naoya Ono; John R Falck; Michal Laniado-Schwartzman
Eicosanoid regulation of vascular endothelial growth factor expression and angiogenesis in microvessel endothelial cells.
The Journal of biological chemistry 2002;277(21):18670-6.
2002: Kathryn M Gauthier; Christine Deeter; U Murali Krishna; Y Krishna Reddy; Muralidhar Bondlela; John R Falck; William B Campbell
14,15-Epoxyeicosa-5(Z)-enoic acid: a selective epoxyeicosatrienoic acid antagonist that inhibits endothelium-dependent hyperpolarization and relaxation in coronary arteries.
Circulation research 2002;90(9):1028-36.
2002: Jorge H Capdevila; Raymond C Harris; John R Falck
Microsomal cytochrome P450 and eicosanoid metabolism.
Cellular and molecular life sciences : CMLS 2002;59(5):780-9.
2002: William B Campbell; Christine Deeter; Kathryn M Gauthier; Richard H Ingraham; John R Falck; Pin-Lan Li
14,15-Dihydroxyeicosatrienoic acid relaxes bovine coronary arteries by activation of K(Ca) channels.
American journal of physiology. Heart and circulatory physiology 2002;282(5):H1656-64.
2002: Wei-Zhong Zeng; Horng-Huei Liou; U Murali Krishna; John R Falck; Chou-Long Huang
Structural determinants and specificities for ROMK1-phosphoinositide interaction.
American journal of physiology. Renal physiology 2002;282(5):F826-34.
2002: Deb K Barma; Abhijit Kundu; Rachid Baati; Charles Mioskowski; John R Falck
A convenient preparation of 3-substituted furans: synthesis of perillene and dendrolasin.
Organic letters 2002;4(8):1387-9.
2002: Y Krishna Reddy; John R Falck
Asymmetric total synthesis of (+)-fostriecin.
Organic letters 2002;4(6):969-71.
2001: Deb K Barma; Rachid Baati; Alain Valleix; Charles Mioskowski; John R Falck
Chromium vinylidene carbenoids: stereospecific synthesis of (Z)-2-chloroalk-2-en-1-ols.
Organic letters 2001;3(26):4237-8.
2001: Mary Pat Kunert; Richard J Roman; John R Falck; Julian H Lombard
Differential effect of cytochrome P-450 omega-hydroxylase inhibition on O2-induced constriction of arterioles in SHR with early and established hypertension.
Microcirculation (New York, N.Y. : 1994) 2001;8(6):435-43.
2001: Fan Zhang; Mong-Heng Wang; U Murali Krishna; John R Falck; Michal Laniado-Schwartzman; Alberto Nasjletti
Modulation by 20-HETE of phenylephrine-induced mesenteric artery contraction in spontaneously hypertensive and Wistar-Kyoto rats.
Hypertension 2001;38(6):1311-5.
2001: Kasem Nithipatikom; A J Grall; Blythe B Holmes; David R Harder; John R Falck; William B Campbell
Liquid chromatographic-electrospray ionization-mass spectrometric analysis of cytochrome P450 metabolites of arachidonic acid.
Analytical biochemistry 2001;298(2):327-36.
2001: Jefferson C Frisbee; U Murali Krishna; John R Falck; Julian H Lombard
Role of prostanoids and 20-HETE in mediating oxygen-induced constriction of skeletal muscle resistance arteries.
Microvascular research 2001;62(3):271-83.
2001: John R Falck; Muralidhar Bondlela; S K Venkataraman; D Srinivas
Bromo-boronolactonization of olefins.
The Journal of organic chemistry 2001;66(21):7148-50.
2001: Rui-Min Gu; Yuan Wei; John R Falck; U Murali Krishna; Wen-Hui Wang
Effects of protein tyrosine kinase and protein tyrosine phosphatase on apical K(+) channels in the TAL.
American journal of physiology. Cell physiology 2001;281(4):C1188-95.
2001: Rachid Baati; Deb K Barma; John R Falck; Charles Mioskowski
Chromium vinylidene carbenoids: generation, characterization, and reactivity. First evidence for an internal proton return phenomenon with vinylidene carbenoids.
Journal of the American Chemical Society 2001;123(37):9196-7.
2001: U Murali Krishna; M Muralidhar Reddy; J Xia; John R Falck; Michael Balazy
Stereospecific synthesis of trans-arachidonic acids.
Bioorganic & medicinal chemistry letters 2001;11(18):2415-8.
2001: Jorge H Capdevila; John R Falck
The CYP P450 arachidonic acid monooxygenases: from cell signaling to blood pressure regulation.
Biochemical and biophysical research communications 2001;285(3):571-6.
2001: Jefferson C Frisbee; Richard J Roman; U Murali Krishna; John R Falck; Julian H Lombard
Relative contributions of cyclooxygenase- and cytochrome P450 omega-hydroxylase-dependent pathways to hypoxic dilation of skeletal muscle resistance arteries.
Journal of vascular research 2001;38(4):305-14.
2001: William B Campbell; John R Falck; Kathryn M Gauthier
Role of epoxyeicosatrienoic acids as endothelium-derived hyperpolarizing factor in bovine coronary arteries.
Medical science monitor : international medical journal of experimental and clinical research 2001;7(4):578-84.
2001: An Huang; Dong Sun; Mairead A Carroll; Houli Jiang; Carolyn J Smith; JA Connetta; John R Falck; Edward Shesely; Ákos Koller; Gabor Kaley
EDHF mediates flow-induced dilation in skeletal muscle arterioles of female eNOS-KO mice.
American journal of physiology. Heart and circulatory physiology 2001;280(6):H2462-9.
2001: Y Wu; An Huang; Dong Sun; John R Falck; Ákos Koller; Gabor Kaley
Gender-specific compensation for the lack of NO in the mediation of flow-induced arteriolar dilation.
American journal of physiology. Heart and circulatory physiology 2001;280(6):H2456-61.
2001: Kasem Nithipatikom; RF DiCamelli; S Kohler; Richard J Gumina; John R Falck; William B Campbell; Garrett J Gross
Determination of cytochrome P450 metabolites of arachidonic acid in coronary venous plasma during ischemia and reperfusion in dogs.
Analytical biochemistry 2001;292(1):115-24.
2001: Vijaykumar R Holla; F Adas; J D Imig; Xueying _ Zhao; Edward Price; Nancy Olsen; William Kovacs; Mark Magnuson; Diane S Keeney; Matthew D Breyer; John R Falck; Michael R Waterman; Jorge H Capdevila
Alterations in the regulation of androgen-sensitive Cyp 4a monooxygenases cause hypertension.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(9):5211-6.
2001: Jefferson C Frisbee; Richard J Roman; U Murali Krishna; John R Falck; Julian H Lombard
Altered mechanisms underlying hypoxic dilation of skeletal muscle resistance arteries of hypertensive versus normotensive Dahl rats.
Microcirculation (New York, N.Y. : 1994) 2001;8(2):115-27.
2001: Mary Pat Kunert; Richard J Roman; Magdalena Alonso-Galicia; John R Falck; Julian H Lombard
Cytochrome P-450 omega-hydroxylase: a potential O(2) sensor in rat arterioles and skeletal muscle cells.
American journal of physiology. Heart and circulatory physiology 2001;280(4):H1840-5.
2001: L Ashley Cowart; John R Falck; Jorge H Capdevila
Structural determinants of active site binding affinity and metabolism by cytochrome P450 BM-3.
Archives of biochemistry and biophysics 2001;387(1):117-24.
2001: S I Pomposiello; Mairead A Carroll; John R Falck; John C McGiff
Epoxyeicosatrienoic acid-mediated renal vasodilation to arachidonic acid is enhanced in SHR.
Hypertension 2001;37(3):887-93.
2001: Jefferson C Frisbee; Richard J Roman; U Murali Krishna; John R Falck; Julian H Lombard
20-HETE modulates myogenic response of skeletal muscle resistance arteries from hypertensive Dahl-SS rats.
American journal of physiology. Heart and circulatory physiology 2001;280(3):H1066-74.
2001: Jefferson C Frisbee; Richard J Roman; John R Falck; U Murali Krishna; Julian H Lombard
20-HETE contributes to myogenic activation of skeletal muscle resistance arteries in Brown Norway and Sprague-Dawley rats.
Microcirculation (New York, N.Y. : 1994) 2001;8(1):45-55.
2000: Daling Zhu; EK Birks; C A Dawson; M Patel; John R Falck; Kenneth W Presberg; Richard J Roman; Elizabeth R Jacobs
Hypoxic pulmonary vasoconstriction is modified by P-450 metabolites.
American journal of physiology. Heart and circulatory physiology 2000;279(4):H1526-33.
2000: Ute R Hoch; John R Falck; Paul R Ortiz de Montellano
Molecular basis for the omega-regiospecificity of the CYP4A2 and CYP4A3 fatty acid hydroxylases.
The Journal of biological chemistry 2000;275(35):26952-8.
2000: John R Falck; U Murali Krishna; Jorge H Capdevila
Preparation of L-alpha-phosphatidyl-D-myo-inositol 3-phosphate (3-PIP) and 3,5-bisphosphate (3,5-PIP2).
Bioorganic & medicinal chemistry letters 2000;10(15):1711-3.
2000: Jorge H Capdevila; John R Falck
Biochemical and molecular characteristics of the cytochrome P450 arachidonic acid monooxygenase.
Prostaglandins & other lipid mediators 2000;62(3):271-92.
2000: Kristopher G Maier; L Henderson; Jayashree Narayanan; Magdalena Alonso-Galicia; John R Falck; Richard J Roman
Fluorescent HPLC assay for 20-HETE and other P-450 metabolites of arachidonic acid.
American journal of physiology. Heart and circulatory physiology 2000;279(2):H863-71.
2000: Debebe Gebremedhin; AR Lange; Timothy F Lowry; M R Taheri; EK Birks; Anthony G Hudetz; Jayashree Narayanan; John R Falck; Hirotsugu Okamoto; Richard J Roman; Kasem Nithipatikom; William B Campbell; David R Harder
Production of 20-HETE and its role in autoregulation of cerebral blood flow.
Circulation research 2000;87(1):60-5.
2000: Cheng-Wen Sun; John R Falck; Hirotsugu Okamoto; David R Harder; Richard J Roman
Role of cGMP versus 20-HETE in the vasodilator response to nitric oxide in rat cerebral arteries.
American journal of physiology. Heart and circulatory physiology 2000;279(1):H339-50.
2000: Popov Serguei; U Murali Krishna; John R Falck; Thomas Wilkie
Ca2+/Calmodulin reverses phosphatidylinositol 3,4, 5-trisphosphate-dependent inhibition of regulators of G protein-signaling GTPase-activating protein activity.
The Journal of biological chemistry 2000;275(25):18962-8.
2000: Raymond Quigley; Michel Baum; Komandla Malla Reddy; James C Griener; John R Falck
Effects of 20-HETE and 19(S)-HETE on rabbit proximal straight tubule volume transport.
American journal of physiology. Renal physiology 2000;278(6):F949-53.
2000: Jefferson C Frisbee; John R Falck; Julian H Lombard
Contribution of cytochrome P-450 omega-hydroxylase to altered arteriolar reactivity with high-salt diet and hypertension.
American journal of physiology. Heart and circulatory physiology 2000;278(5):H1517-26.
2000: Lyuba Glouchankova; U Murali Krishna; B V Potter; John R Falck; Ilya Bezprozvanny
Association of the inositol (1,4,5)-trisphosphate receptor ligand binding site with phosphatidylinositol (4,5)-bisphosphate and adenophostin A.
Molecular cell biology research communications : MCBRC 2000;3(3):153-8.
2000: Rachid Baati; Alain Valleix; Charles Mioskowski; Deb K Barma; John R Falck
A convenient synthesis of 2-tetrahydrofuranyl ethers.
Organic letters 2000;2(4):485-7.
2000: Jorge H Capdevila; John R Falck; Raymond C Harris
Cytochrome P450 and arachidonic acid bioactivation. Molecular and functional properties of the arachidonate monooxygenase.
Journal of lipid research 2000;41(2):163-81.
2000: Daling Zhu; Michael Bousamra; Darryl C Zeldin; John R Falck; Mary I Townsley; David R Harder; Richard J Roman; Elizabeth R Jacobs
Epoxyeicosatrienoic acids constrict isolated pressurized rabbit pulmonary arteries.
American journal of physiology. Lung cellular and molecular physiology 2000;278(2):L335-43.
1999: Magdalena Alonso-Galicia; John R Falck; Komandla Malla Reddy; Richard J Roman
20-HETE agonists and antagonists in the renal circulation.
The American journal of physiology 1999;277(5 Pt 2):F790-6.
1999: Gilles Truan; M R Komandla; John R Falck; Julian A Peterson
P450BM-3: absolute configuration of the primary metabolites of palmitic acid.
Archives of biochemistry and biophysics 1999;366(2):192-8.
1999: X Nguyen; Mong-Heng Wang; K M Reddy; John R Falck; Michal L Schwartzman
Kinetic profile of the rat CYP4A isoforms: arachidonic acid metabolism and isoform-specific inhibitors.
The American journal of physiology 1999;276(6 Pt 2):R1691-700.
1999: Jian-Kang Chen; D W Wang; John R Falck; Jorge Capdevila; Raymond C Harris
Transfection of an active cytochrome P450 arachidonic acid epoxygenase indicates that 14,15-epoxyeicosatrienoic acid functions as an intracellular second messenger in response to epidermal growth factor.
The Journal of biological chemistry 1999;274(8):4764-9.
1999: Jorge H Capdevila; Vijaykumar R Holla; christian helvig; John R Falck
Microsomal cytochrome P450 and eicosanoid metabolism.
Molecular aspects of medicine 1999;20(1-2):42-55, 56-137.
1999: Elizabeth R Jacobs; Richard M Effros; John R Falck; Komandla Malla Reddy; William B Campbell; Daling Zhu
Airway synthesis of 20-hydroxyeicosatetraenoic acid: metabolism by cyclooxygenase to a bronchodilator.
The American journal of physiology 1999;276(2 Pt 1):L280-8.
1999: Julian H Lombard; Mary Pat Kunert; Richard J Roman; John R Falck; David R Harder; William F Jackson
Cytochrome P-450 omega-hydroxylase senses O2 in hamster muscle, but not cheek pouch epithelium, microcirculation.
The American journal of physiology 1999;276(2 Pt 2):H503-8.
1999: Cheng-Wen Sun; John R Falck; David R Harder; Richard J Roman
Role of tyrosine kinase and PKC in the vasoconstrictor response to 20-HETE in renal arterioles.
Hypertension 1999;33(1 Pt 2):414-8.
1999: Beverly A Rzigalinski; Karen A Willoughby; SW Hoffman; John R Falck; Earl F Ellis
Calcium influx factor, further evidence it is 5, 6-epoxyeicosatrienoic acid.
The Journal of biological chemistry 1999;274(1):175-82.
1998: C Vafeas; Paul A Mieyal; F Urbano; John R Falck; K Chauhan; M Berman; Michal L Schwartzman
Hypoxia stimulates the synthesis of cytochrome P450-derived inflammatory eicosanoids in rabbit corneal epithelium.
The Journal of pharmacology and experimental therapeutics 1998;287(3):903-10.
1998: Cheng-Wen Sun; Magdalena Alonso-Galicia; M R Taheri; John R Falck; David R Harder; Richard J Roman
Nitric oxide-20-hydroxyeicosatetraenoic acid interaction in the regulation of K+ channel activity and vascular tone in renal arterioles.
Circulation research 1998;83(11):1069-79.
1998: Sandra L Pfister; Nancy Spitzbarth; Kasem Nithipatikom; WS Edgemond; John R Falck; William B Campbell
Identification of the 11,14,15- and 11,12, 15-trihydroxyeicosatrienoic acids as endothelium-derived relaxing factors of rabbit aorta.
The Journal of biological chemistry 1998;273(47):30879-87.
1998: Jian-Kang Chen; John R Falck; K M Reddy; Jorge Capdevila; Raymond C Harris
Epoxyeicosatrienoic acids and their sulfonimide derivatives stimulate tyrosine phosphorylation and induce mitogenesis in renal epithelial cells.
The Journal of biological chemistry 1998;273(44):29254-61.
1998: Magdalena Alonso-Galicia; Cheng-Wen Sun; John R Falck; David R Harder; Richard J Roman
Contribution of 20-HETE to the vasodilator actions of nitric oxide in renal arteries.
The American journal of physiology 1998;275(3 Pt 2):F370-8.
1998: David J Fulton; John R Falck; John C McGiff; Mairead A Carroll; John Quilley
A method for the determination of 5,6-EET using the lactone as an intermediate in the formation of the diol.
Journal of lipid research 1998;39(8):1713-21.
1998: WS Edgemond; Cecilia J Hillard; John R Falck; Christopher S Kearn; William B Campbell
Human platelets and polymorphonuclear leukocytes synthesize oxygenated derivatives of arachidonylethanolamide (anandamide): their affinities for cannabinoid receptors and pathways of inactivation.
Molecular pharmacology 1998;54(1):180-8.
1998: Vitalie Lupu; Elena Kaznacheyeva; U Murali Krishna; John R Falck; Ilya Bezprozvanny
Functional coupling of phosphatidylinositol 4,5-bisphosphate to inositol 1,4,5-trisphosphate receptor.
The Journal of biological chemistry 1998;273(23):14067-70.
1998: Mong-Heng Wang; E Brand-Schieber; Barbara A Zand; X Nguyen; John R Falck; N Balu; Michal L Schwartzman
Cytochrome P450-derived arachidonic acid metabolism in the rat kidney: characterization of selective inhibitors.
The Journal of pharmacology and experimental therapeutics 1998;284(3):966-73.
1998: Phillip F Pratt; John R Falck; Komandla Malla Reddy; Joseph Kurian; William B Campbell
20-HETE relaxes bovine coronary arteries through the release of prostacyclin.
Hypertension 1998;31(1 Pt 2):237-41.
1997: Mairead A Carroll; Michael Balazy; D D Huang; S Rybalova; John R Falck; John C McGiff
Cytochrome P450-derived renal HETEs: storage and release.
Kidney international 1997;51(6):1696-702.
1997: Kasem Nithipatikom; John R Falck; R K Bhatt; Craig J Hanke; William B Campbell
Determination of 14,15-epoxyeicosatrienoic acid and 14,15-dihydroxyeicosatrienoic acid by fluoroimmunoassay.
Analytical biochemistry 1997;246(2):253-9.
1997: SE Graham-Lorence; Gilles Truan; Julian A Peterson; John R Falck; S Wei; christian helvig; Jorge H Capdevila
An active site substitution, F87V, converts cytochrome P450 BM-3 into a regio- and stereoselective (14S,15R)-arachidonic acid epoxygenase.
The Journal of biological chemistry 1997;272(2):1127-35.
1997: K Mao; K K Reddy; John R Falck; John C McGiff; Michael Balazy
New group of lipid mediators containing omega-hydroxyarachadonic acid (20-HETE).
Advances in experimental medicine and biology 1997;433():55-9.
1997: Magdalena Alonso-Galicia; Heather A Drummond; K K Reddy; John R Falck; Richard J Roman
Inhibition of 20-HETE production contributes to the vascular responses to nitric oxide.
Hypertension 1997;29(1 Pt 2):320-5.
1996: M Lu; Y Zhu; Michael Balazy; K M Reddy; John R Falck; Wenhui Wang
Effect of angiotensin II on the apical K+ channel in the thick ascending limb of the rat kidney.
The Journal of general physiology 1996;108(6):537-47.
1996: K Makita; John R Falck; Jorge H Capdevila
Cytochrome P450, the arachidonic acid cascade, and hypertension: new vistas for an old enzyme system.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1996;10(13):1456-63.
1996: W T Doerrler; J Ye; John R Falck; Mark A Lehrman
Acylation of glucosaminyl phosphatidylinositol revisited. Palmitoyl-CoA dependent palmitoylation of the inositol residue of a synthetic dioctanoyl glucosaminyl phosphatidylinositol by hamster membranes permits efficient mannosylation of the glucosamine residue.
The Journal of biological chemistry 1996;271(43):27031-8.
1996: Mairead A Carroll; Michael Balazy; P Margiotta; D D Huang; John R Falck; John C McGiff
Cytochrome P-450-dependent HETEs: profile of biological activity and stimulation by vasoactive peptides.
The American journal of physiology 1996;271(4 Pt 2):R863-9.
1996: Jorge H Capdevila; S Wei; christian helvig; John R Falck; Y Belosludtsev; Gilles Truan; S E Graham-Lorence; Julian A Peterson
The highly stereoselective oxidation of polyunsaturated fatty acids by cytochrome P450BM-3.
The Journal of biological chemistry 1996;271(37):22663-71.
1996: Ai-Ping Zou; J T Fleming; John R Falck; Elizabeth R Jacobs; Debebe Gebremedhin; David R Harder; Richard J Roman
Stereospecific effects of epoxyeicosatrienoic acids on renal vascular tone and K(+)-channel activity.
The American journal of physiology 1996;270(5 Pt 2):F822-32.
1996: M Rosolowsky; John R Falck; W B Campbell
Metabolism of arachidonic acid by canine polymorphonuclear leukocytes synthesis of lipoxygenase and omega-oxidized metabolites.
Biochimica et biophysica acta 1996;1300(2):143-50.
1996: Ai-Ping Zou; J T Fleming; John R Falck; Elizabeth R Jacobs; Debebe Gebremedhin; David R Harder; Richard J Roman
20-HETE is an endogenous inhibitor of the large-conductance Ca(2+)-activated K+ channel in renal arterioles.
The American journal of physiology 1996;270(1 Pt 2):R228-37.
1996: J D Imig; Ai-Ping Zou; D E Stec; David R Harder; John R Falck; Richard J Roman
Formation and actions of 20-hydroxyeicosatetraenoic acid in rat renal arterioles.
The American journal of physiology 1996;270(1 Pt 2):R217-27.
1995: E Hildebrandt; Joseph P Albanesi; John R Falck; W B Campbell
Regulation of calcium influx and catecholamine secretion in chromaffin cells by a cytochrome P450 metabolite of arachidonic acid.
Journal of lipid research 1995;36(12):2599-608.
1995: F Lin; A Rios; John R Falck; Y Belosludtsev; Michal L Schwartzman
20-Hydroxyeicosatetraenoic acid is formed in response to EGF and is a mitogen in rat proximal tubule.
The American journal of physiology 1995;269(6 Pt 2):F806-16.
1995: D C Zeldin; Raymond DuBois; John R Falck; Jorge H Capdevila
Molecular cloning, expression and characterization of an endogenous human cytochrome P450 arachidonic acid epoxygenase isoform.
Archives of biochemistry and biophysics 1995;322(1):76-86.
1995: Y Sakairi; H R Jacobson; T D Noland; Jorge H Capdevila; John R Falck; Matthew D Breyer
5,6-EET inhibits ion transport in collecting duct by stimulating endogenous prostaglandin synthesis.
The American journal of physiology 1995;268(5 Pt 2):F931-9.
1995: D C Zeldin; J D Plitman; J Kobayashi; R F Miller; JR Snapper; John R Falck; J L Szarek; R M Philpot; Jorge H Capdevila
The rabbit pulmonary cytochrome P450 arachidonic acid metabolic pathway: characterization and significance.
The Journal of clinical investigation 1995;95(5):2150-60.
1995: Ai-Ping Zou; E E Muirhead; Allen W Cowley; David L Mattson; John R Falck; J Jiang; Richard J Roman
Role of changes in renal hemodynamics and P-450 metabolites of arachidonic acid in the reversal of one-kidney, one clip hypertension.
Journal of hypertension 1995;13(5):557-66.
1995: Jorge H Capdevila; J D Morrow; Y Y Belosludtsev; D R Beauchamp; Raymond DuBois; John R Falck
The catalytic outcomes of the constitutive and the mitogen inducible isoforms of prostaglandin H2 synthase are markedly affected by glutathione and glutathione peroxidase(s).
Biochemistry 1995;34(10):3325-37.
1995: D C Zeldin; S Wei; John R Falck; B D Hammock; JR Snapper; Jorge H Capdevila
Metabolism of epoxyeicosatrienoic acids by cytosolic epoxide hydrolase: substrate structural determinants of asymmetric catalysis.
Archives of biochemistry and biophysics 1995;316(1):443-51.
1995: M S Conners; Michal L Schwartzman; X Quan; E Heilman; K Chauhan; John R Falck; H P Godfrey
Enhancement of delayed hypersensitivity inflammatory reactions in guinea pig skin by 12(R)-hydroxy-5,8,14-eicosatrienoic acid.
The Journal of investigative dermatology 1995;104(1):47-51.
1994: K Makita; K Takahashi; A Karara; H R Jacobson; John R Falck; Jorge H Capdevila
Experimental and/or genetically controlled alterations of the renal microsomal cytochrome P450 epoxygenase induce hypertension in rats fed a high salt diet.
The Journal of clinical investigation 1994;94(6):2414-20.
1994: Michal Laniado-Schwartzman; Y Lavrovsky; R A Stoltz; M S Conners; John R Falck; K Chauhan; Nader G Abraham
Activation of nuclear factor kappa B and oncogene expression by 12(R)-hydroxyeicosatrienoic acid, an angiogenic factor in microvessel endothelial cells.
The Journal of biological chemistry 1994;269(39):24321-7.
1994: Ai-Ping Zou; J D Imig; Paul R. Ortiz de Montellano; Z Sui; John R Falck; Richard J Roman
Effect of P-450 omega-hydroxylase metabolites of arachidonic acid on tubuloglomerular feedback.
The American journal of physiology 1994;266(6 Pt 2):F934-41.
1994: Bruno A Escalante; D Erlij; John R Falck; John C McGiff
Cytochrome P-450 arachidonate metabolites affect ion fluxes in rabbit medullary thick ascending limb.
The American journal of physiology 1994;266(6 Pt 1):C1775-82.
1994: David R Harder; Debebe Gebremedhin; Jayashree Narayanan; C Jefcoat; John R Falck; William B Campbell; Richard J Roman
Formation and action of a P-450 4A metabolite of arachidonic acid in cat cerebral microvessels.
The American journal of physiology 1994;266(5 Pt 2):H2098-107.
1994: S Yamamoto; M Nishimura; M S Conners; R A Stoltz; John R Falck; K Chauhan; Michal Laniado-Schwartzman
Oxidation and keto reduction of 12-hydroxy-5,8,10,14-eicosatetraenoic acids in bovine corneal epithelial microsomes.
Biochimica et biophysica acta 1994;1210(2):217-25.
1993: C Macica; Michael Balazy; John R Falck; C Mioskowski; Mairead A Carroll
Characterization of cytochrome P-450-dependent arachidonic acid metabolism in rabbit intestine.
The American journal of physiology 1993;265(4 Pt 1):G735-41.
1993: J D Imig; John R Falck; Debebe Gebremedhin; David R Harder; Richard J Roman
Elevated renovascular tone in young spontaneously hypertensive rats. Role of cytochrome P-450.
Hypertension 1993;22(3):357-64.
1993: A Karara; K Makita; H R Jacobson; John R Falck; F Peter Guengerich; Raymond DuBois; Jorge H Capdevila
Molecular cloning, expression, and enzymatic characterization of the rat kidney cytochrome P-450 arachidonic acid epoxygenase.
The Journal of biological chemistry 1993;268(18):13565-70.
1993: Mairead A Carroll; Michael Balazy; P Margiotta; John R Falck; John C McGiff
Renal vasodilator activity of 5,6-epoxyeicosatrienoic acid depends upon conversion by cyclooxygenase and release of prostaglandins.
The Journal of biological chemistry 1993;268(17):12260-6.
1993: Bruno A Escalante; K Omata; William C Sessa; S G Lee; John R Falck; Michal L Schwartzman
20-hydroxyeicosatetraenoic acid is an endothelium-dependent vasoconstrictor in rabbit arteries.
European journal of pharmacology 1993;235(1):1-7.
1993: D C Zeldin; J Kobayashi; John R Falck; B S Winder; B D Hammock; JR Snapper; Jorge H Capdevila
Regio- and enantiofacial selectivity of epoxyeicosatrienoic acid hydration by cytosolic epoxide hydrolase.
The Journal of biological chemistry 1993;268(9):6402-7.
1993: Y H Ma; Debebe Gebremedhin; M L Schwartzman; John R Falck; J E Clark; Bettie Sue Masters; David R Harder; Richard J Roman
20-Hydroxyeicosatetraenoic acid is an endogenous vasoconstrictor of canine renal arcuate arteries.
Circulation research 1993;72(1):126-36.
1993: Bruno A Escalante; D Erlij; John R Falck; John C McGiff
Cytochrome P450-dependent arachidonate metabolites affect renal transport in the rabbit.
Journal of cardiovascular pharmacology 1993;22 Suppl 2():S106-8.
1992: Jorge H Capdevila; S Wei; A Kumar; J Kobayashi; JR Snapper; D C Zeldin; R K Bhatt; John R Falck
Resolution of dihydroxyeicosanoates and of dihydroxyeicosatrienoates by chiral phase chromatography.
Analytical biochemistry 1992;207(2):236-40.
1992: Jorge H Capdevila; S Wei; J Yan; A Karara; H R Jacobson; John R Falck; F Peter Guengerich; Raymond DuBois
Cytochrome P-450 arachidonic acid epoxygenase. Regulatory control of the renal epoxygenase by dietary salt loading.
The Journal of biological chemistry 1992;267(30):21720-6.
1992: William Henrich; John R Falck; W B Campbell
Inhibition of renin secretion from rat renal cortical slices by (R)-12-HETE.
The American journal of physiology 1992;263(4 Pt 2):F665-70.
1992: Debebe Gebremedhin; Y H Ma; John R Falck; Richard J Roman; M VanRollins; David R Harder
Mechanism of action of cerebral epoxyeicosatrienoic acids on cerebral arterial smooth muscle.
The American journal of physiology 1992;263(2 Pt 2):H519-25.
1992: C Prakash; J Y Zhang; John R Falck; K Chauhan; Ian A Blair
20-Hydroxyeicosatetraenoic acid is excreted as a glucuronide conjugate in human urine.
Biochemical and biophysical research communications 1992;185(2):728-33.
1992: A Karara; S Wei; D Spady; Larry L Swift; Jorge H Capdevila; John R Falck
Arachidonic acid epoxygenase: structural characterization and quantification of epoxyeicosatrienoates in plasma.
Biochemical and biophysical research communications 1992;182(3):1320-5.
1992: S C Amruthesh; John R Falck; Earl F Ellis
Brain synthesis and cerebrovascular action of epoxygenase metabolites of arachidonic acid.
Journal of neurochemistry 1992;58(2):503-10.
1992: Jorge H Capdevila; John R Falck; R W Estabrook
Cytochrome P450 and the arachidonate cascade.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1992;6(2):731-6.
1992: H K Jajoo; Jorge H Capdevila; John R Falck; R K Bhatt; Ian A Blair
Metabolism of 12(R)-hydroxyeicosatetraenoic acid by rat liver microsomes.
Biochimica et biophysica acta 1992;1123(1):110-6.
1992: Mairead A Carroll; M P Garcia; John R Falck; John C McGiff
Cyclooxygenase dependency of the renovascular actions of cytochrome P450-derived arachidonate metabolites.
The Journal of pharmacology and experimental therapeutics 1992;260(1):104-9.
1991: M Nishimura; Michal L Schwartzman; John R Falck; S Lumin; J A Zirrolli; Robert C Murphy
Metabolism of 12(R)-hydroxy-5,8,10,14-eicosatetraenoic acid (12(R)-HETE) in corneal tissues: formation of novel metabolites.
Archives of biochemistry and biophysics 1991;290(2):326-35.
1991: Michal L Schwartzman; K Omata; F M Lin; R K Bhatt; John R Falck; Nader G Abraham
Detection of 20-hydroxyeicosatetraenoic acid in rat urine.
Biochemical and biophysical research communications 1991;180(1):445-9.
1991: T Katoh; K Takahashi; Jorge Capdevila; A Karara; John R Falck; H R Jacobson; KAMAL BADR
Glomerular stereospecific synthesis and hemodynamic actions of 8,9-epoxyeicosatrienoic acid in rat kidney.
The American journal of physiology 1991;261(4 Pt 2):F578-86.
1991: S L Pfister; John R Falck; W B Campbell
Enhanced synthesis of epoxyeicosatrienoic acids by cholesterol-fed rabbit aorta.
The American journal of physiology 1991;261(3 Pt 2):H843-52.
1991: A Karara; E Dishman; John R Falck; Jorge H Capdevila
Endogenous epoxyeicosatrienoyl-phospholipids. A novel class of cellular glycerolipids containing epoxidized arachidonate moieties.
The Journal of biological chemistry 1991;266(12):7561-9.
1991: W B Campbell; Michael T Brady; L J Rosolowsky; John R Falck
Metabolism of arachidonic acid by rat adrenal glomerulosa cells: synthesis of hydroxyeicosatetraenoic acids and epoxyeicosatrienoic acids.
Endocrinology 1991;128(4):2183-94.
1991: J L Masferrer; J A Rimarachin; M E Gerritsen; John R Falck; P Yadagiri; Michael W Dunn; Michal Laniado-Schwartzman
12(R)-hydroxyeicosatrienoic acid, a potent chemotactic and angiogenic factor produced by the cornea.
Experimental eye research 1991;52(4):417-24.
1991: Bruno A Escalante; D Erlij; John R Falck; John C McGiff
Effect of cytochrome P450 arachidonate metabolites on ion transport in rabbit kidney loop of Henle.
Science (New York, N.Y.) 1991;251(4995):799-802.
1991: K Bernstrom; K Malcolm; J McGee; J Maclouf; S Levy-Toledano; John R Falck; F A Fitzpatrick
14, 15-cis-episulfide-eicosatrienoic acid, an 'epoxygenase' eicosanoid analog, inhibits ionophore- but not thrombin-induced platelet aggregation.
Molecular pharmacology 1991;39(2):114-9.
1991: Bruno A Escalante; D Erlij; John R Falck; John C McGiff
Ion transport inhibition in the medullary thick ascending limb of Henle's loop by cytochrome P450-arachidonic acid metabolites.
Advances in prostaglandin, thromboxane, and leukotriene research 1991;21A():209-12.
1991: M Rosolowsky; John R Falck; W B Campbell
Synthesis and biological activity of epoxyeicosatrienoic acids (EETs) by cultured bovine coronary artery endothelial cells.
Advances in prostaglandin, thromboxane, and leukotriene research 1991;21A():213-6.
1991: Jorge H Capdevila; E Dishman; A Karara; John R Falck
Cytochrome P450 arachidonic acid epoxygenase: stereochemical characterization of epoxyeicosatrienoic acids.
Methods in enzymology 1991;206():441-53.
1990: Mairead A Carroll; M P Garcia; John R Falck; John C McGiff
5,6-epoxyeicosatrienoic acid, a novel arachidonate metabolite. Mechanism of vasoactivity in the rat.
Circulation research 1990;67(5):1082-8.
1990: Bruno A Escalante; William C Sessa; John R Falck; P Yadagiri; Michal L Schwartzman
Cytochrome P450-dependent arachidonic acid metabolites, 19- and 20-hydroxyeicosatetraenoic acids, enhance sodium-potassium ATPase activity in vascular smooth muscle.
Journal of cardiovascular pharmacology 1990;16(3):438-43.
1990: A Karara; E Dishman; H Jacobson; John R Falck; Jorge H Capdevila
Arachidonic acid epoxygenase. Stereochemical analysis of the endogenous epoxyeicosatrienoic acids of human kidney cortex.
FEBS letters 1990;268(1):227-30.
1990: Jorge H Capdevila; A Karara; D J Waxman; M V Martin; John R Falck; F P Guenguerich
Cytochrome P-450 enzyme-specific control of the regio- and enantiofacial selectivity of the microsomal arachidonic acid epoxygenase.
The Journal of biological chemistry 1990;265(19):10865-71.
1990: John R Falck; S Lumin; I Blair; E Dishman; M V Martin; D J Waxman; F P Guengerich; Jorge H Capdevila
Cytochrome P-450-dependent oxidation of arachidonic acid to 16-, 17-, and 18-hydroxyeicosatetraenoic acids.
The Journal of biological chemistry 1990;265(18):10244-9.
1990: K Takahashi; Jorge Capdevila; A Karara; John R Falck; H R Jacobson; KAMAL BADR
Cytochrome P-450 arachidonate metabolites in rat kidney: characterization and hemodynamic responses.
The American journal of physiology 1990;258(4 Pt 2):F781-9.
1990: M Rosolowsky; John R Falck; James T Willerson; W B Campbell
Synthesis of lipoxygenase and epoxygenase products of arachidonic acid by normal and stenosed canine coronary arteries.
Circulation research 1990;66(3):608-21.
1990: M P Junier; F Dray; I Blair; J Capdevila; E Dishman; John R Falck; Sergio R Ojeda
Epoxygenase products of arachidonic acid are endogenous constituents of the hypothalamus involved in D2 receptor-mediated, dopamine-induced release of somatostatin.
Endocrinology 1990;126(3):1534-40.
1990: William Henrich; John R Falck; W B Campbell
Inhibition of renin release by 14,15-epoxyeicosatrienoic acid in renal cortical slices.
The American journal of physiology 1990;258(2 Pt 1):E269-74.
1990: Jorge H Capdevila; John R Falck; E Dishman; A Karara
Cytochrome P-450 arachidonate oxygenase.
Methods in enzymology 1990;187():385-94.
1990: John R Falck; P Yadagiri; J Capdevila
Synthesis of epoxyeicosatrienoic acids and heteroatom analogs.
Methods in enzymology 1990;187():357-64.
1990: K Malcolm; John R Falck; F A Fitzpatrick
Novel eicosanoids generated by cytochrome P450: effects on platelet aggregation and protein phosphorylation.
Advances in prostaglandin, thromboxane, and leukotriene research 1990;20():87-94.
1989: D L Hirt; Jorge Capdevila; John R Falck; Matthew D Breyer; H R Jacobson
Cytochrome P450 metabolites of arachidonic acid are potent inhibitors of vasopressin action on rabbit cortical collecting duct.
The Journal of clinical investigation 1989;84(6):1805-12.
1989: A Karara; E Dishman; I Blair; John R Falck; Jorge H Capdevila
Endogenous epoxyeicosatrienoic acids. Cytochrome P-450 controlled stereoselectivity of the hepatic arachidonic acid epoxygenase.
The Journal of biological chemistry 1989;264(33):19822-7.
1989: T D Hammonds; Ian A Blair; John R Falck; Jorge H Capdevila
Resolution of epoxyeicosatrienoate enantiomers by chiral phase chromatography.
Analytical biochemistry 1989;182(2):300-3.
1989: F Belardetti; W B Campbell; John R Falck; G Demontis; M Rosolowsky
Products of heme-catalyzed transformation of the arachidonate derivative 12-HPETE open S-type K+ channels in Aplysia.
Neuron 1989;3(4):497-505.
1989: Michal L Schwartzman; John R Falck; P Yadagiri; Bruno A Escalante
Metabolism of 20-hydroxyeicosatetraenoic acid by cyclooxygenase. Formation and identification of novel endothelium-dependent vasoconstrictor metabolites.
The Journal of biological chemistry 1989;264(20):11658-62.
1989: B O Ibe; John R Falck; A R Johnson; W B Campbell
Regulation of synthesis of prostacyclin and HETEs in human endothelial cells.
The American journal of physiology 1989;256(6 Pt 1):C1168-75.
1989: John R Falck; S Lumin; P Yadagiri; D S Shin
Chemical syntheses of trioxilins.
Advances in prostaglandin, thromboxane, and leukotriene research 1989;19():635-8.
1989: Bruno A Escalante; William C Sessa; John R Falck; P Yadagiri; Michal L Schwartzman
Vasoactivity of 20-hydroxyeicosatetraenoic acid is dependent on metabolism by cyclooxygenase.
The Journal of pharmacology and experimental therapeutics 1989;248(1):229-32.
1988: Robert C Murphy; John R Falck; S Lumin; P Yadagiri; J A Zirrolli; Michael Balazy; J L Masferrer; Nader G Abraham; Michal L Schwartzman
12(R)-hydroxyeicosatrienoic acid: a vasodilator cytochrome P-450-dependent arachidonate metabolite from the bovine corneal epithelium.
The Journal of biological chemistry 1988;263(32):17197-202.
1988: Bruno A Escalante; John R Falck; P Yadagiri; L M Sun; Michal Laniado-Schwartzman
19(S)-hydroxyeicosatetraenoic acid is a potent stimulator of renal Na+-K+-ATPase.
Biochemical and biophysical research communications 1988;152(3):1269-74.
1988: L Lapuerta; N Chacos; John R Falck; H Jacobson; Jorge H Capdevila
Renal microsomal cytochrome P-450 and the oxidative metabolism of arachidonic acid.
The American journal of the medical sciences 1988;295(4):275-9.
1988: J Capdevila; Lionel Gil; Myriam Orellana; Lawrence J Marnett; J I Mason; P Yadagiri; John R Falck
Inhibitors of cytochrome P-450-dependent arachidonic acid metabolism.
Archives of biochemistry and biophysics 1988;261(2):257-63.
1988: Jorge H Capdevila; P Mosset; P Yadagiri; S Lumin; John R Falck
NADPH-dependent microsomal metabolism of 14,15-epoxyeicosatrienoic acid to diepoxides and epoxyalcohols.
Archives of biochemistry and biophysics 1988;261(1):122-33.
1987: Jorge H Capdevila; V Kishore; E Dishman; Ian Blair; John R Falck
A novel pool of rat liver inositol and ethanolamine phospholipids contains epoxyeicosatrienoic acids (EETs).
Biochemical and biophysical research communications 1987;146(2):638-44.
1987: John R Falck; V J Schueler; H R Jacobson; A K Siddhanta; B Pramanik; J Capdevila
Arachidonate epoxygenase: identification of epoxyeicosatrienoic acids in rabbit kidney.
Journal of lipid research 1987;28(7):840-6.
1987: R Toto; A Siddhanta; S Manna; B Pramanik; John R Falck; J Capdevila
Arachidonic acid epoxygenase: detection of epoxyeicosatrienoic acids in human urine.
Biochimica et biophysica acta 1987;919(2):132-9.
1986: J Capdevila; P Yadagiri; S Manna; John R Falck
Absolute configuration of the hydroxyeicosatetraenoic acids (HETEs) formed during catalytic oxygenation of arachidonic acid by microsomal cytochrome P-450.
Biochemical and biophysical research communications 1986;141(3):1007-11.
1986: G Snyder; F Lattanzio; P Yadagiri; John R Falck; J Capdevila
5,6-Epoxyeicosatrienoic acid mobilizes Ca2+ in anterior pituitary cells.
Biochemical and biophysical research communications 1986;139(3):1188-94.
1985: J Capdevila; Y R Kim; C Martin-Wixtrom; John R Falck; S Manna; Ronald W Estabrook
Influence of a fibric acid type of hypolipidemic agent on the oxidative metabolism of arachidonic acid by liver microsomal cytochrome P-450.
Archives of biochemistry and biophysics 1985;243(1):8-19.
1985: M E Spearman; Russell A Prough; Ronald W Estabrook; John R Falck; S Manna; K C Leibman; R C Murphy; J Capdevila
Novel glutathione conjugates formed from epoxyeicosatrienoic acids (EETs).
Archives of biochemistry and biophysics 1985;242(1):225-30.
1985: andres negro vilar; G D Snyder; John R Falck; S Manna; N Chacos; J Capdevila
Involvement of eicosanoids in release of oxytocin and vasopressin from the neural lobe of the rat pituitary.
Endocrinology 1985;116(6):2663-8.
1984: J Capdevila; B Pramanik; J L Napoli; S Manna; John R Falck
Arachidonic acid epoxidation: epoxyeicosatrienoic acids are endogenous constituents of rat liver.
Archives of biochemistry and biophysics 1984;231(2):511-7.
1983: John R Falck; S Manna; J Moltz; N Chacos; J Capdevila
Epoxyeicosatrienoic acids stimulate glucagon and insulin release from isolated rat pancreatic islets.
Biochemical and biophysical research communications 1983;114(2):743-9.
1983: J Capdevila; N Chacos; John R Falck; S Manna; andres negro vilar; Sergio R Ojeda
Novel hypothalamic arachidonate products stimulate somatostatin release from the median eminence.
Endocrinology 1983;113(1):421-3.
1983: N Chacos; J Capdevila; John R Falck; S Manna; C Martin-Wixtrom; S S Gill; B D Hammock; Ronald W Estabrook
The reaction of arachidonic acid epoxides (epoxyeicosatrienoic acids) with a cytosolic epoxide hydrolase.
Archives of biochemistry and biophysics 1983;223(2):639-48.
1983: gary snyder; J Capdevila; N Chacos; S Manna; John R Falck
Action of luteinizing hormone-releasing hormone: involvement of novel arachidonic acid metabolites.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(11):3504-7.
1982: N Chacos; John R Falck; C Wixtrom; J Capdevila
Novel epoxides formed during the liver cytochrome P-450 oxidation of arachidonic acid.
Biochemical and biophysical research communications 1982;104(3):916-22.