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Michela Falco

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Mariella Della Chiesa; Michela Falco; Francesco Frassoni; Franco Locatelli; Lorenzo Moretta; Marina Podestà; Alessandro Moretta
Phenotypic and functional heterogeneity of human NK cells developing after umbilical cord blood transplantation: a role for human cytomegalovirus?
Simona Sivori; Simona Carlomagno; Michela Falco; Elisa Romeo; Lorenzo Moretta; Alessandro Moretta
Natural killer cells expressing the KIR2DS1-activating receptor efficiently kill T-cell blasts and dendritic cells: implications in haploidentical HSCT.
Simona Sivori; Michela Falco; Simona Carlomagno; Elisa Romeo; Cristiana Soldani; Armand Bensussan; Antonella Viola; Lorenzo Moretta; Alessandro Moretta
A novel KIR-associated function: evidence that CpG DNA uptake and shuttling to early endosomes is mediated by KIR3DL2.

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All Publications

2012: Mariella Della Chiesa; Michela Falco; Francesco Frassoni; Franco Locatelli; Lorenzo Moretta; Marina Podestà; Alessandro Moretta
Phenotypic and functional heterogeneity of human NK cells developing after umbilical cord blood transplantation: a role for human cytomegalovirus?
Blood 2012;119(2):399-410.
2011: Simona Sivori; Simona Carlomagno; Michela Falco; Elisa Romeo; Lorenzo Moretta; Alessandro Moretta
Natural killer cells expressing the KIR2DS1-activating receptor efficiently kill T-cell blasts and dendritic cells: implications in haploidentical HSCT.
Blood 2011;117(16):4284-92.
2010: Simona Sivori; Michela Falco; Simona Carlomagno; Elisa Romeo; Cristiana Soldani; Armand Bensussan; Antonella Viola; Lorenzo Moretta; Alessandro Moretta
A novel KIR-associated function: evidence that CpG DNA uptake and shuttling to early endosomes is mediated by KIR3DL2.
Blood 2010;116(10):1637-47.
2010: Simona Sivori; Michela Falco; Lorenzo Moretta; Alessandro Moretta
Extending killer Ig-like receptor function: from HLA class I recognition to sensors of microbial products.
Trends in immunology 2010;31(8):289-94.
2010: Mariella Della Chiesa; Michela Falco; Silvia Parolini; Francesca Bellora; Andrea Petretto; Elisa Romeo; Mirna Balsamo; Marco Gambarotti; Francesca Scordamaglia; Giovanna Tabellini; Fabio Facchetti; william vermi; Cristina Bottino; Alessandro Moretta; Massimo Vitale
GPR56 as a novel marker identifying the CD56dull CD16+ NK cell subset both in blood stream and in inflamed peripheral tissues.
International immunology 2010;22(2):91-100.
2009: Paolo Carrega; Gaetana Pezzino; Paola Queirolo; Irene Bonaccorsi; Michela Falco; Giuseppe Vita; Daniela Pende; Aldo Misefari; Alessandro Moretta; Maria Cristina Mingari; Lorenzo Moretta; Guido Ferlazzo
Susceptibility of human melanoma cells to autologous natural killer (NK) cell killing: HLA-related effector mechanisms and role of unlicensed NK cells.
PloS one 2009;4(12):e8132.
2008: Emanuela Marcenaro; Bruna Ferranti; Michela Falco; Lorenzo Moretta; Alessandro Moretta
Human NK cells directly recognize Mycobacterium bovis via TLR2 and acquire the ability to kill monocyte-derived DC.
International immunology 2008;20(9):1155-67.
2008: Mariella Della Chiesa; Elisa Romeo; Michela Falco; Mirna Balsamo; Raffaella Augugliaro; Lorenzo Moretta; Cristina Bottino; Alessandro Moretta; Massimo Vitale
Evidence that the KIR2DS5 gene codes for a surface receptor triggering natural killer cell function.
European journal of immunology 2008;38(8):2284-9.
2007: Simona Sivori; Michela Falco; Simona Carlomagno; Elisa Romeo; Lorenzo Moretta; Alessandro Moretta
Heterogeneity of TLR3 mRNA transcripts and responsiveness to poly (I:C) in human NK cells derived from different donors.
International immunology 2007;19(12):1341-8.
2007: Chiara Romagnani; Kerstin Juelke; Michela Falco; Barbara Morandi; Antonella D'Agostino; Roberta Costa; Giovanni B Ratto; Giuseppe Forte; Paolo Carrega; Gabrielle Lui; Romana Conte; Till Strowig; Alessandro Moretta; Christian Münz; Andreas Thiel; Lorenzo Moretta; Guido Ferlazzo
CD56brightCD16- killer Ig-like receptor- NK cells display longer telomeres and acquire features of CD56dim NK cells upon activation.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(8):4947-55.
2006: Paola Vacca; Gabriella Pietra; Michela Falco; Elisa Romeo; Cristina Bottino; Francesca Bellora; Federico Prefumo; Ezio Fulcheri; Pier Luigi Venturini; mauro costa; Alessandro Moretta; Lorenzo Moretta; Maria Cristina Mingari
Analysis of natural killer cells isolated from human decidua: Evidence that 2B4 (CD244) functions as an inhibitory receptor and blocks NK-cell function.
Blood 2006;108(13):4078-85.
2006: Hilary L Hoare; Lucy C Sullivan; Gabriella Pietra; Craig S Clements; Eleanor J Lee; Lauren K Ely; Travis Beddoe; Michela Falco; Lars Kjer-Nielsen; Hugh Reid; James McCluskey; Lorenzo Moretta; Jamie Rossjohn; Andrew G Brooks
Structural basis for a major histocompatibility complex class Ib-restricted T cell response.
Nature immunology 2006;7(3):256-64.
2005: Paola Mazzarino; Gabriella Pietra; Paola Vacca; Michela Falco; Didier Colau; Pierre G Coulie; Lorenzo Moretta; Maria Cristina Mingari
Identification of effector-memory CMV-specific T lymphocytes that kill CMV-infected target cells in an HLA-E-restricted fashion.
European journal of immunology 2005;35(11):3240-7.
2005: Barbara Morandi; Roberta Costa; Michela Falco; Silvia Parolini; Andrea De Maria; Giovanni B Ratto; Maria Cristina Mingari; Giovanni Melioli; Alessandro Moretta; Guido Ferlazzo
Distinctive lack of CD48 expression in subsets of human dendritic cells tunes NK cell activation.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(6):3690-7.
2005: Daniela Pende; Grazia Maria Spaggiari; Stefania Marcenaro; Stefania Martini; Paola Rivera; Andrea Capobianco; Michela Falco; Edoardo Lanino; Ivana Pierri; Renato Zambello; Andrea Bacigalupo; Maria Cristina Mingari; Alessandro Moretta; Lorenzo Moretta
Analysis of the receptor-ligand interactions in the natural killer-mediated lysis of freshly isolated myeloid or lymphoblastic leukemias: evidence for the involvement of the Poliovirus receptor (CD155) and Nectin-2 (CD112).
Blood 2005;105(5):2066-73.
2004: Massimo Vitale; Simona Carlomagno; Michela Falco; Daniela Pende; Elisa Romeo; Paola Rivera; Mariella Della Chiesa; Domenico Mavilio; Alessandro Moretta
Isolation of a novel KIR2DL3-specific mAb: comparative analysis of the surface distribution and function of KIR2DL2, KIR2DL3 and KIR2DS2.
International immunology 2004;16(10):1459-66.
2004: Simona Sivori; Michela Falco; Mariella Della Chiesa; Simona Carlomagno; Massimo Vitale; Lorenzo Moretta; Alessandro Moretta
CpG and double-stranded RNA trigger human NK cells by Toll-like receptors: induction of cytokine release and cytotoxicity against tumors and dendritic cells.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(27):10116-21.
2004: Michela Falco; Emanuela Marcenaro; Elisa Romeo; Francesca Bellora; Daniele Marras; Frédéric Vély; Géraldine Ferracci; Lorenzo Moretta; Alessandro Moretta; Cristina Bottino
Homophilic interaction of NTBA, a member of the CD2 molecular family: induction of cytotoxicity and cytokine release in human NK cells.
European journal of immunology 2004;34(6):1663-72.
2004: Chiara Romagnani; Gabriella Pietra; Michela Falco; Paola Mazzarino; Lorenzo Moretta; Maria Cristina Mingari
HLA-E-restricted recognition of human cytomegalovirus by a subset of cytolytic T lymphocytes.
Human immunology 2004;65(5):437-45.
2003: Emanuela Marcenaro; Raffaella Augugliaro; Michela Falco; Roberta Castriconi; Silvia Parolini; Simona Sivori; Elisa Romeo; Romano Millo; Lorenzo Moretta; Cristina Bottino; Alessandro Moretta
CD59 is physically and functionally associated with natural cytotoxicity receptors and activates human NK cell-mediated cytotoxicity.
European journal of immunology 2003;33(12):3367-76.
2003: Roberto Biassoni; Claudia Cantoni; D Marras; Julien Giron-Michel; Michela Falco; Lorenzo Moretta; Nazzareno Dimasi
Human natural killer cell receptors: insights into their molecular function and structure.
Journal of cellular and molecular medicine 2003;7(4):376-87.
2003: Gabriella Pietra; Chiara Romagnani; Paola Mazzarino; Michela Falco; Enrico Millo; Alessandro Moretta; Lorenzo Moretta; Maria Cristina Mingari
HLA-E-restricted recognition of cytomegalovirus-derived peptides by human CD8+ cytolytic T lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(19):10896-901.
2003: Renato Zambello; Michela Falco; Mariella Della Chiesa; Livio Trentin; Davide Carollo; Roberta Castriconi; Giovanna Cannas; Simona Carlomagno; Anna Cabrelle; Thierry Lamy; Carlo Agostini; Alessandro Moretta; Gianpietro Semenzato; Massimo Vitale
Expression and function of KIR and natural cytotoxicity receptors in NK-type lymphoproliferative diseases of granular lymphocytes.
Blood 2003;102(5):1797-805.
2002: Chiara Romagnani; Gabriella Pietra; Michela Falco; Enrico Millo; Paola Mazzarino; Roberto Biassoni; Alessandro Moretta; Lorenzo Moretta; Maria Cristina Mingari
Identification of HLA-E-specific alloreactive T lymphocytes: a cell subset that undergoes preferential expansion in mixed lymphocyte culture and displays a broad cytolytic activity against allogeneic cells.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(17):11328-33.
2002: Simona Sivori; Michela Falco; Emanuela Marcenaro; Silvia Parolini; Roberto Biassoni; Cristina Bottino; Lorenzo Moretta; Alessandro Moretta
Early expression of triggering receptors and regulatory role of 2B4 in human natural killer cell precursors undergoing in vitro differentiation.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(7):4526-31.
2001: Gabriella Pietra; Chiara Romagnani; Michela Falco; Massimo Vitale; Roberta Castriconi; Daniela Pende; Enrico Millo; S Anfossi; Roberto Biassoni; Lorenzo Moretta; Maria Cristina Mingari
The analysis of the natural killer-like activity of human cytolytic T lymphocytes revealed HLA-E as a novel target for TCR alpha/beta-mediated recognition.
European journal of immunology 2001;31(12):3687-93.
2001: Cristina Bottino; Michela Falco; Silvia Parolini; Emanuela Marcenaro; Raffaella Augugliaro; Simona Sivori; E Landi; Roberto Biassoni; Luigi D Notarangelo; Lorenzo Moretta; Alessandro Moretta
NTB-A [correction of GNTB-A], a novel SH2D1A-associated surface molecule contributing to the inability of natural killer cells to kill Epstein-Barr virus-infected B cells in X-linked lymphoproliferative disease.
The Journal of experimental medicine 2001;194(3):235-46.
2001: Maria Cristina Mingari; Chiara Vitale; Chiara Romagnani; Michela Falco; Lorenzo Moretta
p75/AIRM1 and CD33, two sialoadhesin receptors that regulate the proliferation or the survival of normal and leukemic myeloid cells.
Immunological reviews 2001;181():260-8.
2001: Cristina Bottino; Silvia Parolini; Roberto Biassoni; Michela Falco; Luigi D Notarangelo; Alessandro Moretta
X-linked lymphoproliferative disease: the dark side of 2b4 function.
Advances in experimental medicine and biology 2001;495():63-7.
2001: Maria Cristina Mingari; Chiara Vitale; Chiara Romagnani; Michela Falco; Lorenzo Moretta
Regulation of myeloid cell proliferation and survival by p75/AIRM1 and CD33 surface receptors.
Advances in experimental medicine and biology 2001;495():55-61.
2001: Massimo Vitale; Michela Falco; Roberta Castriconi; Silvia Parolini; Renato Zambello; G Semenzato; Roberto Biassoni; Cristina Bottino; Lorenzo Moretta; Alessandro Moretta
Identification of NKp80, a novel triggering molecule expressed by human NK cells.
European journal of immunology 2001;31(1):233-42.
2000: Roberto Biassoni; Claudia Cantoni; Michela Falco; Daniela Pende; Romano Millo; Lorenzo Moretta; Cristina Bottino; Alessandro Moretta
Human natural killer cell activating receptors.
Molecular immunology 2000;37(17):1015-24.
2000: Cristina Bottino; Michela Falco; Simona Sivori; Lorenzo Moretta; Alessandro Moretta; Roberto Biassoni
Identification and molecular characterization of a natural mutant of the p50.2/KIR2DS2 activating NK receptor that fails to mediate NK cell triggering.
European journal of immunology 2000;30(12):3569-74.
2000: Silvia Parolini; Cristina Bottino; Michela Falco; Raffaella Augugliaro; Silvia Giliani; R Franceschini; H D Ochs; H Wolf; J Y Bonnefoy; Roberto Biassoni; Lorenzo Moretta; Luigi D Notarangelo; Alessandro Moretta
X-linked lymphoproliferative disease. 2B4 molecules displaying inhibitory rather than activating function are responsible for the inability of natural killer cells to kill Epstein-Barr virus-infected cells.
The Journal of experimental medicine 2000;192(3):337-46.
2000: Simona Sivori; Silvia Parolini; Michela Falco; Emanuela Marcenaro; Roberto Biassoni; Cristina Bottino; Lorenzo Moretta; Alessandro Moretta
2B4 functions as a co-receptor in human NK cell activation.
European journal of immunology 2000;30(3):787-93.
1999: Chiara Vitale; Chiara Romagnani; Michela Falco; M Ponte; Massimo Vitale; Alessandro Moretta; Andrea Bacigalupo; Lorenzo Moretta; Maria Cristina Mingari
Engagement of p75/AIRM1 or CD33 inhibits the proliferation of normal or leukemic myeloid cells.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(26):15091-6.
1999: Michela Falco; Roberto Biassoni; Cristina Bottino; Massimo Vitale; Simona Sivori; Raffaella Augugliaro; Lorenzo Moretta; Alessandro Moretta
Identification and molecular cloning of p75/AIRM1, a novel member of the sialoadhesin family that functions as an inhibitory receptor in human natural killer cells.
The Journal of experimental medicine 1999;190(6):793-802.
1999: Claudia Cantoni; Michela Falco; A Pessino; Alessandro Moretta; Lorenzo Moretta; Roberto Biassoni
P49, a putative HLA-G1 specific inhibitory NK receptor belonging to the immunoglobulin Superfamily.
Journal of reproductive immunology 1999;43(2):157-65.
1999: Michela Falco; Claudia Cantoni; Cristina Bottino; Alessandro Moretta; Roberto Biassoni
Identification of the rat homologue of the human NKp46 triggering receptor.
Immunology letters 1999;68(2-3):411-4.
1998: Claudia Semino; Gabriella Pietra; A Semino; Michela Falco; Marco Varaldo; Giovanni Melioli
Normal epithelial cells modulating HLA class I surface molecules are susceptible to lysis mediated by CD3(+) and CD3(-) "nonspecific" killer cells.
Cellular immunology 1998;190(2):183-90.
1998: Claudia Cantoni; S Verdiani; Michela Falco; A Pessino; Michele Cilli; Romana Conte; Daniela Pende; M Ponte; M S Mikaelsson; Lorenzo Moretta; Roberto Biassoni
p49, a putative HLA class I-specific inhibitory NK receptor belonging to the immunoglobulin superfamily.
European journal of immunology 1998;28(6):1980-90.
1997: Daniela Pende; Simona Sivori; L Accame; L Pareti; Michela Falco; D Geraghty; P Le Bouteiller; Lorenzo Moretta; Alessandro Moretta
HLA-G recognition by human natural killer cells. Involvement of CD94 both as inhibitory and as activating receptor complex.
European journal of immunology 1997;27(8):1875-80.
1996: Cristina Bottino; Simona Sivori; M Vitale; Claudia Cantoni; Michela Falco; Daniela Pende; L Morelli; Raffaella Augugliaro; G Semenzato; Roberto Biassoni; Lorenzo Moretta; Alessandro Moretta
A novel surface molecule homologous to the p58/p50 family of receptors is selectively expressed on a subset of human natural killer cells and induces both triggering of cell functions and proliferation.
European journal of immunology 1996;26(8):1816-24.
1996: Daniela Pende; Roberto Biassoni; Claudia Cantoni; S Verdiani; Michela Falco; C di Donato; L Accame; Cristina Bottino; Alessandro Moretta; Lorenzo Moretta
The natural killer cell receptor specific for HLA-A allotypes: a novel member of the p58/p70 family of inhibitory receptors that is characterized by three immunoglobulin-like domains and is expressed as a 140-kD disulphide-linked dimer.
The Journal of experimental medicine 1996;184(2):505-18.
1996: Roberto Biassoni; Claudia Cantoni; Michela Falco; S Verdiani; Cristina Bottino; M Vitale; R Conte; Alessandro Poggi; Alessandro Moretta; Lorenzo Moretta
The human leukocyte antigen (HLA)-C-specific "activatory" or "inhibitory" natural killer cell receptors display highly homologous extracellular domains but differ in their transmembrane and intracytoplasmic portions.
The Journal of experimental medicine 1996;183(2):645-50.
1996: Claudia Cantoni; S Verdiani; Michela Falco; R Conte; Roberto Biassoni
Molecular structures of HLA-specific human NK cell receptors.
Chemical immunology 1996;64():88-103.
1995: Roberto Biassoni; Michela Falco; A Cambiaggi; P Costa; S Verdiani; Daniela Pende; R Conte; C Di Donato; P Parham; Lorenzo Moretta
Amino acid substitutions can influence the natural killer (NK)-mediated recognition of HLA-C molecules. Role of serine-77 and lysine-80 in the target cell protection from lysis mediated by "group 2" or "group 1" NK clones.
The Journal of experimental medicine 1995;182(2):605-9.
1992: G Angelini; G Morozzi; Laura Delfino; C Pera; Michela Falco; R Marcolongo; S Giannelli; G Ratti; S Ricci; G Fanetti
Analysis of HLA DP, DQ, and DR alleles in adult Italian rheumatoid arthritis patients.
Human immunology 1992;34(2):135-41.
1992: M Vitale; Maria Pia Pistillo; Pier Luigi Tazzari; Michela Falco; P F Sun; Stefano Mantero; Giovanni Battista Ferrara
Production and characterization of murine monoclonal antibodies recognizing HLA-DQ polymorphisms obtained by immunizing mice with transfected L cells.
Human immunology 1992;34(2):126-34.
1991: O Mazzoleni; Maria Pia Pistillo; Michela Falco; Pier Luigi Tazzari; Giovanni Battista Ferrara
Characterization of two human monoclonal antibodies recognizing HLA-A30 and HLA-A3 + A31, respectively.
Tissue antigens 1991;38(5):224-7.
1991: Maria Pia Pistillo; Pier Luigi Tazzari; O Mazzoleni; A Urlacher; Michela Falco; M Vitale; R W Karr; Giovanni Battista Ferrara
Analysis of HLA specificity of human monoclonal antibodies by cytofluorimetry and cell ELISA.
European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics 1991;18(5-6):345-53.
1991: Maria Pia Pistillo; O Mazzoleni; L Kun; Michela Falco; Pier Luigi Tazzari; Giovanni Battista Ferrara
Production of two human hybridomas secreting antibodies to HLA-DRw11 and--DRw8+w12 specificities.
Human immunology 1991;31(2):86-93.