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Maria Falkenberg

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Chemicals & Drugs

Physiology

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Publications

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Sjoerd Wanrooij; Claes M Gustafsson; Nils-Göran Larsson; Javier Miralles Fusté; Tore Samuelsson; James B Stewart; Paulina Wanrooij; Maria Falkenberg
In vivo mutagenesis reveals that OriL is essential for mitochondrial DNA replication.
Géraldine Farge; Martina Gaspari; Claes M Gustafsson; Niels Laurens; Erwin J G Peterman; Siet M J L van den Wildenberg; Onno D Broekmans; Linda C M Dekker; Maria Falkenberg; Gijs J L Wuite
Protein sliding and DNA denaturation are essential for DNA organization by human mitochondrial transcription factor A.
Elisabeth Jemt; Stefan Bäckström; Géraldine Farge; Claes M Gustafsson; Teresa Holmlund; Maria Falkenberg
The mitochondrial DNA helicase TWINKLE can assemble on a closed circular template and support initiation of DNA synthesis.

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All Publications

2012: Sjoerd Wanrooij; Claes M Gustafsson; Nils-Göran Larsson; Javier Miralles Fusté; Tore Samuelsson; James B Stewart; Paulina Wanrooij; Maria Falkenberg
In vivo mutagenesis reveals that OriL is essential for mitochondrial DNA replication.
EMBO reports 2012;13(12):1130-7.
2012: Géraldine Farge; Martina Gaspari; Claes M Gustafsson; Niels Laurens; Erwin J G Peterman; Siet M J L van den Wildenberg; Onno D Broekmans; Linda C M Dekker; Maria Falkenberg; Gijs J L Wuite
Protein sliding and DNA denaturation are essential for DNA organization by human mitochondrial transcription factor A.
Nature communications 2012;3():1013.
2011: Elisabeth Jemt; Stefan Bäckström; Géraldine Farge; Claes M Gustafsson; Teresa Holmlund; Maria Falkenberg
The mitochondrial DNA helicase TWINKLE can assemble on a closed circular template and support initiation of DNA synthesis.
Nucleic acids research 2011;39(21):9238-49.
2011: Magnus K Bjursell; Henk J Blom; Göran Brandberg; Jordi Asin Cayuela; Martin L Engvall; Maria Falkenberg; Claes M Gustafsson; Maria Halldin; Cornelis Jakobs; Nicole Lesko; Joakim Lundeberg; Desiree Smith; Eduard Struys; Ulrika von Döbeln; Shanti Balasubramaniam; Anna Wedell
Adenosine kinase deficiency disrupts the methionine cycle and causes hypermethioninemia, encephalopathy, and abnormal liver function.
American journal of human genetics 2011;89(4):507-15.
2011: Neli Atanassova; Javier Miralles Fusté; Sjoerd Wanrooij; Bertil Macao; Steffi Goffart; Stefan Bäckström; Géraldine Farge; Ivan Khvorostov; Nils-Göran Larsson; Johannes N Spelbrink; Maria Falkenberg
Sequence-specific stalling of DNA polymerase γ and the effects of mutations causing progressive ophthalmoplegia.
Human molecular genetics 2011;20(6):1212-23.
2010: Sjoerd Wanrooij; Maria Falkenberg
The human mitochondrial replication fork in health and disease.
Biochimica et biophysica acta 2010;1797(8):1378-88.
2010: Javier Miralles Fusté; Sjoerd Wanrooij; Elisabeth Jemt; Caroline E Granycome; Tricia J Cluett; Yonghong Shi; Neli Atanassova; Ian J Holt; Claes M Gustafsson; Maria Falkenberg
Mitochondrial RNA polymerase is needed for activation of the origin of light-strand DNA replication.
Molecular cell 2010;37(1):67-78.
2009: Teresa Holmlund; Géraldine Farge; Vineet Pande; Jenny Korhonen; Lennart Nilsson; Maria Falkenberg
Structure-function defects of the twinkle amino-terminal region in progressive external ophthalmoplegia.
Biochimica et biophysica acta 2009;1792(2):132-9.
2008: Sjoerd Wanrooij; Javier Miralles Fusté; Géraldine Farge; Yonghong Shi; Claes M Gustafsson; Maria Falkenberg
Human mitochondrial RNA polymerase primes lagging-strand DNA synthesis in vitro.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(32):11122-7.
2008: Jenny A Korhonen; Vineet Pande; Teresa Holmlund; Géraldine Farge; Xuan Hoi Pham; Lennart Nilsson; Maria Falkenberg
Structure-function defects of the TWINKLE linker region in progressive external ophthalmoplegia.
Journal of molecular biology 2008;377(3):691-705.
2008: Géraldine Farge; Teresa Holmlund; Julia Khvorostova; Reza Rofougaran; Anders Hofer; Maria Falkenberg
The N-terminal domain of TWINKLE contributes to single-stranded DNA binding and DNA helicase activities.
Nucleic acids research 2008;36(2):393-403.
2007: Chan Bae Park; Jorge Asin-Cayuela; Yolanda Cámara; Yonghong Shi; Mina Pellegrini; Martina Gaspari; Rolf Wibom; Kjell Hultenby; Hediye Erdjument-Bromage; Paul Tempst; Maria Falkenberg; Claes M Gustafsson; Nils-Göran Larsson
MTERF3 is a negative regulator of mammalian mtDNA transcription.
Cell 2007;130(2):273-85.
2007: Maria Falkenberg; Nils-Göran Larsson; Claes M Gustafsson
DNA replication and transcription in mammalian mitochondria.
Annual review of biochemistry 2007;76():679-99.
2007: Géraldine Farge; Xuan Hoi Pham; Teresa Holmlund; Ivan Khorostov; Maria Falkenberg
The accessory subunit B of DNA polymerase gamma is required for mitochondrial replisome function.
Nucleic acids research 2007;35(3):902-11.
2006: Xuan Hoi Pham; Géraldine Farge; Yonghong Shi; Martina Gaspari; Claes M Gustafsson; Maria Falkenberg
Conserved sequence box II directs transcription termination and primer formation in mitochondria.
The Journal of biological chemistry 2006;281(34):24647-52.
2005: Tomas Linder; Chan Bae Park; Jordi Asin-Cayuela; Mina Pellegrini; Nils-Göran Larsson; Maria Falkenberg; Tore Samuelsson; Claes M Gustafsson
A family of putative transcription termination factors shared amongst metazoans and plants.
Current genetics 2005;48(4):265-9.
2004: Martina Gaspari; Maria Falkenberg; Nils-Göran Larsson; Claes M Gustafsson
The mitochondrial RNA polymerase contributes critically to promoter specificity in mammalian cells.
The EMBO journal 2004;23(23):4606-14.
2004: Jenny A Korhonen; Xuan Hoi Pham; Mina Pellegrini; Maria Falkenberg
Reconstitution of a minimal mtDNA replisome in vitro.
The EMBO journal 2004;23(12):2423-9.
2004: Aleksandra Trifunovic; Anna Wredenberg; Maria Falkenberg; Johannes N Spelbrink; Anja T Rovio; Carl Bruder; Mohammad Bohlooly-Y; Sebastian Gidlöf; Anders Oldfors; Rolf Wibom; Jan Törnell; Howard T Jacobs; Nils-Göran Larsson
Premature ageing in mice expressing defective mitochondrial DNA polymerase.
Nature 2004;429(6990):417-23.
2004: Mats I Ekstrand; Maria Falkenberg; Anja Rantanen; Chan Bae Park; Martina Gaspari; Kjell Hultenby; Pierre Rustin; Claes M Gustafsson; Nils-Göran Larsson
Mitochondrial transcription factor A regulates mtDNA copy number in mammals.
Human molecular genetics 2004;13(9):935-44.
2003: Jenny A Korhonen; Martina Gaspari; Maria Falkenberg
TWINKLE Has 5' -> 3' DNA helicase activity and is specifically stimulated by mitochondrial single-stranded DNA-binding protein.
The Journal of biological chemistry 2003;278(49):48627-32.
2003: Anja Rantanen; Martina Gaspari; Maria Falkenberg; Claes M Gustafsson; Nils-Göran Larsson
Characterization of the mouse genes for mitochondrial transcription factors B1 and B2.
Mammalian genome : official journal of the International Mammalian Genome Society 2003;14(1):1-6.
2002: Maria Falkenberg; Martina Gaspari; Anja Rantanen; Aleksandra Trifunovic; Nils-Göran Larsson; Claes M Gustafsson
Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA.
Nature genetics 2002;31(3):289-94.