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Xianjun Fang

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Shuying Liu; Makiko Umezu-Goto; Mandi Murph; Yiling Lu; Wenbin Liu; Fan Zhang; Shuangxing Yu; L Clifton Stephens; Xiaojiang Cui; George Murrow; Kevin Coombes; William Muller; Mien-Chie Hung; Charles M Perou; Adrian V Lee; Xianjun Fang; Gordon B Mills
Expression of autotaxin and lysophosphatidic acid receptors increases mammary tumorigenesis, invasion, and metastases.
Shuangxing Yu; Mandi Murph; Yiling Lu; Shuying Liu; Hassan S Hall; Jinsong Liu; Clifton Stephens; Xianjun Fang; Gordon B Mills
Lysophosphatidic acid receptors determine tumorigenicity and aggressiveness of ovarian cancer cells.
Shuying Liu; Xianjun Fang; Hassan Hall; Shuangxing Yu; Debra Smith; Zhimin Lu; Dexing Fang; Jinsong Liu; L Clifton Stephens; James R Woodgett; Gordon B Mills
Homozygous deletion of glycogen synthase kinase 3beta bypasses senescence allowing Ras transformation of primary murine fibroblasts.

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2009: Shuying Liu; Makiko Umezu-Goto; Mandi Murph; Yiling Lu; Wenbin Liu; Fan Zhang; Shuangxing Yu; L Clifton Stephens; Xiaojiang Cui; George Murrow; Kevin Coombes; William Muller; Mien-Chie Hung; Charles M Perou; Adrian V Lee; Xianjun Fang; Gordon B Mills
Expression of autotaxin and lysophosphatidic acid receptors increases mammary tumorigenesis, invasion, and metastases.
Cancer cell 2009;15(6):539-50.
2008: Shuangxing Yu; Mandi Murph; Yiling Lu; Shuying Liu; Hassan S Hall; Jinsong Liu; Clifton Stephens; Xianjun Fang; Gordon B Mills
Lysophosphatidic acid receptors determine tumorigenicity and aggressiveness of ovarian cancer cells.
Journal of the National Cancer Institute 2008;100(22):1630-42.
2008: Shuying Liu; Xianjun Fang; Hassan Hall; Shuangxing Yu; Debra Smith; Zhimin Lu; Dexing Fang; Jinsong Liu; L Clifton Stephens; James R Woodgett; Gordon B Mills
Homozygous deletion of glycogen synthase kinase 3beta bypasses senescence allowing Ras transformation of primary murine fibroblasts.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(13):5248-53.
2004: Shuying Liu; Shuangxing Yu; Yutaka Hasegawa; Ruth Lapushin; Hong-Ji Xu; James R Woodgett; Gordon B Mills; Xianjun Fang
Glycogen synthase kinase 3beta is a negative regulator of growth factor-induced activation of the c-Jun N-terminal kinase.
The Journal of biological chemistry 2004;279(49):51075-81.
2004: Yasunari Takada; Xianjun Fang; Md Saha Jamaluddin; Douglas D Boyd; Bharat B Aggarwal
Genetic deletion of glycogen synthase kinase-3beta abrogates activation of IkappaBalpha kinase, JNK, Akt, and p44/p42 MAPK but potentiates apoptosis induced by tumor necrosis factor.
The Journal of biological chemistry 2004;279(38):39541-54.
2004: Xianjun Fang; Shuangxing Yu; Robert C Bast; Shuying Liu; Hong-Ji Xu; Shi-Xue Hu; Ruth Lapushin; Francois Claret; Bharat B Aggarwal; Yiling Lu; Gordon B Mills
Mechanisms for lysophosphatidic acid-induced cytokine production in ovarian cancer cells.
The Journal of biological chemistry 2004;279(10):9653-61.
2003: Yiling Lu; Qinghua Yu; Jue Hui Liu; Jinyi Zhang; Hongwei Wang; Dimpy Koul; John S McMurray; Xianjun Fang; W K Alfred Yung; Katherine A Siminovitch; Gordon B Mills
Src family protein-tyrosine kinases alter the function of PTEN to regulate phosphatidylinositol 3-kinase/AKT cascades.
The Journal of biological chemistry 2003;278(41):40057-66.
2003: Gordon B Mills; Elise C Kohn; Yiling Lu; Astrid Eder; Xianjun Fang; Hongwei Wang; Robert C Bast; Joe Gray; Robert Jaffe; Gabriel Hortobagyi
Linking molecular diagnostics to molecular therapeutics: targeting the PI3K pathway in breast cancer.
Seminars in oncology 2003;30(5 Suppl 16):93-104.
2003: Robert Z Luo; Xianjun Fang; Rebecca T Marquez; Shu-Ying Liu; Gordon B Mills; Warren S-L Liao; Yinhua Yu; Robert C Bast
ARHI is a Ras-related small G-protein with a novel N-terminal extension that inhibits growth of ovarian and breast cancers.
Oncogene 2003;22(19):2897-909.
2003: Yutaka Hasegawa; James R Erickson; Graham J Goddard; Shuangxing Yu; Shuying Liu; Kwai Wa Cheng; Astrid Eder; Koji Bandoh; Junken Aoki; Renata Jarosz; Andrew D Schrier; Kevin R Lynch; Gordon B Mills; Xianjun Fang
Identification of a phosphothionate analogue of lysophosphatidic acid (LPA) as a selective agonist of the LPA3 receptor.
The Journal of biological chemistry 2003;278(14):11962-9.
2003: Janos L Tanyi; Andrew J Morris; Judith K Wolf; Xianjun Fang; Yutaka Hasegawa; Ruth Lapushin; Nelly Auersperg; Yury J Sigal; Robert A Newman; Edward Felix; E Neely Atkinson; Gordon B Mills
The human lipid phosphate phosphatase-3 decreases the growth, survival, and tumorigenesis of ovarian cancer cells: validation of the lysophosphatidic acid signaling cascade as a target for therapy in ovarian cancer.
Cancer research 2003;63(5):1073-82.
2003: Gordon B Mills; Xianjun Fang; Yiling Lu; Yutaka Hasegawa; Astrid Eder; Janos L Tanyi; Fazal H Tabassam; Muling Mao; Hongwei Wang; Kwai Wa Cheng; Yasuhisa Nakayama; Wenlin Kuo; Jim Erickson; David M Gershenson; Elise C Kohn; Robert Jaffe; Robert C Bast; Joe Gray
Specific keynote: molecular therapeutics in ovarian cancer.
Gynecologic oncology 2003;88(1 Pt 2):S88-92; discussion S93-6.
2002: Xianjun Fang; Michel Schummer; Muling Mao; Shuangxing Yu; Fazal H Tabassam; Ramona Swaby; Yutaka Hasegawa; Janos L Tanyi; Ruth Lapushin; Astrid Eder; Robert Jaffe; Jim Erickson; Gordon B Mills
Lysophosphatidic acid is a bioactive mediator in ovarian cancer.
Biochimica et biophysica acta 2002;1582(1-3):257-64.
2002: Xianjun Fang; Shuangxing Yu; Janos L Tanyi; Yiling Lu; James R Woodgett; Gordon B Mills
Convergence of multiple signaling cascades at glycogen synthase kinase 3: Edg receptor-mediated phosphorylation and inactivation by lysophosphatidic acid through a protein kinase C-dependent intracellular pathway.
Molecular and cellular biology 2002;22(7):2099-110.
2002: Gordon B Mills; Astrid Eder; Xianjun Fang; Yutaka Hasegawa; Muling Mao; Yiling Lu; Janos L Tanyi; Fazal H Tabassam; Jon R Wiener; Ruth Lapushin; Shiangxing Yu; Jeff A Parrott; Tim Compton; Walter Tribley; David Fishman; M Sharon Stack; Douglas Gaudette; Robert Jaffe; Tatsuro Furui; Junken Aoki; James R Erickson
Critical role of lysophospholipids in the pathophysiology, diagnosis, and management of ovarian cancer.
Cancer treatment and research 2002;107():259-83.