FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

David Abraham

Research Profile

Anatomy

Disorders

Chemicals & Drugs

Living Beings

Mouse

Physiology

Phenomena

Phosphorylation

Co-author Network

Publications

TOP 3
Carmel J Stock; Athol U Wells; Anne-Marie Russell; Hiroe Sato; David J Abraham; Huzaifa Adamali; Winston A S Banya; Christopher P Denton; Carmen Fonseca; David M Hansell; Gisela E Lindahl; Toby M Maher; Philip L Molyneaux; Andrew G Nicholson; Elisabetta A Renzoni
Mucin 5B promoter polymorphism is associated with idiopathic pulmonary fibrosis but not with development of lung fibrosis in systemic sclerosis or sarcoidosis.
Angelo De Lauretis; Christopher P Denton; Nicole S L Goh; David M Hansell; Laureen Hector; Rachel Hoyles; Peter Kelleher; Toby M Maher; Voon H Ong; Panagiotis Pantelidis; Piersante Sestini; Dina Visca; Athol U Wells; Christopher J Zappala; David J Abraham; Elisabetta A Renzoni
Serum interleukin 6 is predictive of early functional decline and mortality in interstitial lung disease associated with systemic sclerosis.
Xu Shi-wen; Katherine Thompson; Murray Baron; Christopher P Denton; Korsa Khan; Andrew Leask; Shangxi Liu; Hannah Murphy-Marshman; David J Abraham
Focal adhesion kinase and reactive oxygen species contribute to the persistent fibrotic phenotype of lesional scleroderma fibroblasts.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of David Abraham (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Carmel J Stock; Athol U Wells; Anne-Marie Russell; Hiroe Sato; David J Abraham; Huzaifa Adamali; Winston A S Banya; Christopher P Denton; Carmen Fonseca; David M Hansell; Gisela E Lindahl; Toby M Maher; Philip L Molyneaux; Andrew G Nicholson; Elisabetta A Renzoni
Mucin 5B promoter polymorphism is associated with idiopathic pulmonary fibrosis but not with development of lung fibrosis in systemic sclerosis or sarcoidosis.
Thorax 2013;68(5):436-41.
2013: Angelo De Lauretis; Christopher P Denton; Nicole S L Goh; David M Hansell; Laureen Hector; Rachel Hoyles; Peter Kelleher; Toby M Maher; Voon H Ong; Panagiotis Pantelidis; Piersante Sestini; Dina Visca; Athol U Wells; Christopher J Zappala; David J Abraham; Elisabetta A Renzoni
Serum interleukin 6 is predictive of early functional decline and mortality in interstitial lung disease associated with systemic sclerosis.
The Journal of rheumatology 2013;40(4):435-46.
2012: Xu Shi-wen; Katherine Thompson; Murray Baron; Christopher P Denton; Korsa Khan; Andrew Leask; Shangxi Liu; Hannah Murphy-Marshman; David J Abraham
Focal adhesion kinase and reactive oxygen species contribute to the persistent fibrotic phenotype of lesional scleroderma fibroblasts.
Rheumatology (Oxford, England) 2012;51(12):2146-54.
2011: Sunil K Parapuram; Xu Shi-wen; Ian D Welch; David J Abraham; Murray Baron; Christopher P Denton; Christopher Elliott; Helen Jones; Andrew Leask
Loss of PTEN expression by dermal fibroblasts causes skin fibrosis.
The Journal of investigative dermatology 2011;131(10):1996-2003.
2011: Alan M Holmes; Markella Ponticos; Xu Shi-wen; Christopher P Denton; David J Abraham
Elevated CCN2 expression in scleroderma: a putative role for the TGFβ accessory receptors TGFβRIII and endoglin.
Journal of cell communication and signaling 2011;5(3):173-7.
2011: Dhiraj Joshi; Hemanshu Patel; Xu Shiwen; David J Abraham; Daryll M Baker; Janice C Tsui
Development of an in vitro model of myotube ischemia.
Laboratory investigation; a journal of technical methods and pathology 2011;91(8):1241-52.
2011: Michael R Dashwood; Audrey Dooley; Xu Shi-wen; David J Abraham; Mats Dreifaldt; Domingos S R Souza
Perivascular fat-derived leptin: a potential role in improved vein graft performance in coronary artery bypass surgery.
Interactive cardiovascular and thoracic surgery 2011;12(2):170-3.
2011: Rachel K Hoyles; Emma C Derrett-Smith; Korsa Khan; Xu Shiwen; Sarah L Howat; Athol U Wells; David J Abraham; Christopher P Denton
An essential role for resident fibroblasts in experimental lung fibrosis is defined by lineage-specific deletion of high-affinity type II transforming growth factor β receptor.
American journal of respiratory and critical care medicine 2011;183(2):249-61.
2011: Matthew McCann; Roxana Monemdjou; Sunil K Parapuram; Gemma Perez; Xu Shi-wen; David J Abraham; Leslie J Crofford; Christopher P Denton; Hassan Fahmi; Parisa Ghassemi-Kakroodi; Fumiaki Kojima; Andrew Leask; Shangxi Liu; Johanne Martel-Pelletier; Mohit Kapoor
mPGES-1 null mice are resistant to bleomycin-induced skin fibrosis.
Arthritis research & therapy 2011;13(1):R6.
2011: Shangxi Liu; Xu Shi-wen; David J Abraham; Andrew Leask
CCN2 is required for bleomycin-induced skin fibrosis in mice.
Arthritis and rheumatism 2011;63(1):239-46.
2010: Shangxi Liu; Shi-wen Xu; Katrin Blumbach; Mark Eastwood; Christopher P Denton; Beate Eckes; Thomas Krieg; David J Abraham; Andrew Leask
Expression of integrin beta1 by fibroblasts is required for tissue repair in vivo.
Journal of cell science 2010;123(Pt 21):3674-82.
2010: Audrey Dooley; Xu Shi-wen; Nima Aden; Thomas Tranah; Nirupa Desai; Christopher P Denton; David J Abraham; Richard Bruckdorfer
Modulation of collagen type I, fibronectin and dermal fibroblast function and activity, in systemic sclerosis by the antioxidant epigallocatechin-3-gallate.
Rheumatology (Oxford, England) 2010;49(11):2024-36.
2010: Nima Aden; Anna Nuttall; Xu Shiwen; Patricia de Winter; Andrew Leask; Carol M Black; Christopher P Denton; David J Abraham; Richard Stratton
Epithelial cells promote fibroblast activation via IL-1alpha in systemic sclerosis.
The Journal of investigative dermatology 2010;130(9):2191-200.
2010: Dhiraj Joshi; Janice C S Tsui; Teik K Ho; Sadasivam Selvakumar; David J Abraham; Daryll M Baker
Review of the role of erythropoietin in critical leg ischemia.
Angiology 2010;61(6):541-50.
2010: Teik K Ho; Janice Tsui; Shiwen Xu; Patricia Leoni; David J Abraham; Daryll M Baker
Angiogenic effects of stromal cell-derived factor-1 (SDF-1/CXCL12) variants in vitro and the in vivo expressions of CXCL12 variants and CXCR4 in human critical leg ischemia.
Journal of vascular surgery 2010;51(3):689-99.
2010: Xu Shi-wen; Mark Eastwood; Richard J Stratton; Christopher P Denton; Andrew Leask; David J Abraham
Rosiglitazone alleviates the persistent fibrotic phenotype of lesional skin scleroderma fibroblasts.
Rheumatology (Oxford, England) 2010;49(2):259-63.
2009: Mohit Kapoor; Matthew McCann; Shangxi Liu; Kun Huh; Christopher P Denton; David J Abraham; Andrew Leask
Loss of peroxisome proliferator-activated receptor gamma in mouse fibroblasts results in increased susceptibility to bleomycin-induced skin fibrosis.
Arthritis and rheumatism 2009;60(9):2822-9.
2009: Shangxi Liu; Mohit Kapoor; Christopher P Denton; David J Abraham; Andrew Leask
Loss of beta1 integrin in mouse fibroblasts results in resistance to skin scleroderma in a mouse model.
Arthritis and rheumatism 2009;60(9):2817-21.
2009: Markella Ponticos; holmes alan; Xu Shi-wen; Patricia Leoni; Korsa Khan; Vineeth S Rajkumar; Rachel K Hoyles; George Bou-Gharios; Carol M Black; Christopher P Denton; David J Abraham; Andrew Leask; Gisela E Lindahl
Pivotal role of connective tissue growth factor in lung fibrosis: MAPK-dependent transcriptional activation of type I collagen.
Arthritis and rheumatism 2009;60(7):2142-55.
2009: David J Abraham; T Krieg; J Distler; O Distler
Overview of pathogenesis of systemic sclerosis.
Rheumatology (Oxford, England) 2009;48 Suppl 3():iii3-7.
2009: Xu Shiwen; Andrew Leask; David J Abraham; C Fonseca
Endothelin receptor selectivity: evidence from in vitro and pre-clinical models of scleroderma.
European journal of clinical investigation 2009;39 Suppl 2():19-26.
2009: Andrew Leask; Sunil K Parapuram; Xu Shi-wen; David J Abraham
Connective tissue growth factor (CTGF, CCN2) gene regulation: a potent clinical bio-marker of fibroproliferative disease?
Journal of cell communication and signaling 2009;3(2):89-94.
2009: Xu Shiwen; Vineeth Rajkumar; Christopher P Denton; Andrew Leask; David J Abraham
Pericytes display increased CCN2 expression upon culturing.
Journal of cell communication and signaling 2009;3(1):61-4.
2009: Voon H Ong; Maria Teresa Carulli; Shiwen Xu; Korsa Khan; Gisela Lindahl; David J Abraham; Christopher P Denton
Cross-talk between MCP-3 and TGFbeta promotes fibroblast collagen biosynthesis.
Experimental cell research 2009;315(2):151-61.
2009: Shi-wen Xu; Shangxi Liu; Mark Eastwood; Sonali Sonnylal; Christopher P Denton; David J Abraham; Andrew Leask
Rac inhibition reverses the phenotype of fibrotic fibroblasts.
PloS one 2009;4(10):e7438.
2009: Xu Shi-wen; Sunil K Parapuram; Daphne Pala; Yunliang Chen; David E Carter; Mark Eastwood; Christopher P Denton; David J Abraham; Andrew Leask
Requirement of transforming growth factor beta-activated kinase 1 for transforming growth factor beta-induced alpha-smooth muscle actin expression and extracellular matrix contraction in fibroblasts.
Arthritis and rheumatism 2009;60(1):234-41.
2008: Andrew Leask; Xu Shi-wen; Korsa Khan; Yunliang Chen; holmes alan; Mark Eastwood; Christopher P Denton; Carol M Black; David J Abraham
Loss of protein kinase Cepsilon results in impaired cutaneous wound closure and myofibroblast function.
Journal of cell science 2008;121(Pt 20):3459-67.
2008: Mohit Kapoor; Shangxi Liu; Xu Shi-wen; Kun Huh; Matthew McCann; Christopher P Denton; James R Woodgett; David J Abraham; Andrew Leask
GSK-3beta in mouse fibroblasts controls wound healing and fibrosis through an endothelin-1-dependent mechanism.
The Journal of clinical investigation 2008;118(10):3279-90.
2008: Shangxi Liu; Mohit Kapoor; Xu Shi-wen; Laura Kennedy; Christopher P Denton; Glogauer Michael; David J Abraham; Andrew Leask
Role of Rac1 in a bleomycin-induced scleroderma model using fibroblast-specific Rac1-knockout mice.
Arthritis and rheumatism 2008;58(7):2189-95.
2008: Laura Kennedy; Xu Shi-wen; David E Carter; David J Abraham; Andrew Leask
Fibroblast adhesion results in the induction of a matrix remodeling gene expression program.
Matrix biology : journal of the International Society for Matrix Biology 2008;27(4):274-81.
2008: Rachel K Hoyles; Korsa Khan; Xu Shiwen; Sarah L Howat; Gisela E Lindahl; Patricia Leoni; Roland M Du Bois; Athol U Wells; Carol M Black; David J Abraham; Christopher P Denton
Fibroblast-specific perturbation of transforming growth factor beta signaling provides insight into potential pathogenic mechanisms of scleroderma-associated lung fibrosis: exaggerated response to alveolar epithelial injury in a novel mouse model.
Arthritis and rheumatism 2008;58(4):1175-88.
2008: Audrey Dooley; Sylvia Y Low; holmes alan; Asmeret G Kidane; David J Abraham; Carol M Black; K Richard Bruckdorfer
Nitric oxide synthase expression and activity in the tight-skin mouse model of fibrosis.
Rheumatology (Oxford, England) 2008;47(3):272-80.
2008: Yunliang Chen; Andrew Leask; David J Abraham; Daphne Pala; Xu Shiwen; Korsa Khan; Shangxi Liu; David E Carter; Sarah Wilcox-Adelman; Paul Goetinck; Christopher P Denton; Carol M Black; Andrew A Pitsillides; Catherine E Sarraf; Mark Eastwood
Heparan sulfate-dependent ERK activation contributes to the overexpression of fibrotic proteins and enhanced contraction by scleroderma fibroblasts.
Arthritis and rheumatism 2008;58(2):577-85.
2007: Xu Shi-wen; Laura Kennedy; Elisabetta A Renzoni; George Bou-Gharios; Roland M Du Bois; Carol M Black; Christopher P Denton; David J Abraham; Andrew Leask
Endothelin is a downstream mediator of profibrotic responses to transforming growth factor beta in human lung fibroblasts.
Arthritis and rheumatism 2007;56(12):4189-94.
2007: Xu Shi-wen; Elisabetta A Renzoni; Laura Kennedy; Sarah Howat; Yunliang Chen; Jeremy Pearson; George Bou-Gharios; Michael R Dashwood; Roland M Du Bois; Carol M Black; Christopher P Denton; David J Abraham; Andrew Leask
Endogenous endothelin-1 signaling contributes to type I collagen and CCN2 overexpression in fibrotic fibroblasts.
Matrix biology : journal of the International Society for Matrix Biology 2007;26(8):625-32.
2007: Carmen Fonseca; Gisela E Lindahl; Markella Ponticos; Piersante Sestini; Elisabetta A Renzoni; holmes alan; Paolo Spagnolo; P Pantelidis; Patricia Leoni; Neil McHugh; Carmel J Stock; Xu Shi-wen; Christopher P Denton; Carol M Black; Kenneth I Welsh; Roland M Du Bois; David J Abraham
A polymorphism in the CTGF promoter region associated with systemic sclerosis.
The New England journal of medicine 2007;357(12):1210-20.
2007: Audrey Dooley; Beirong Gao; Xu Shi-wen; David J Abraham; Carol M Black; Michael Jacobs; K Richard Bruckdorfer
Effect of nitric oxide and peroxynitrite on type I collagen synthesis in normal and scleroderma dermal fibroblasts.
Free radical biology & medicine 2007;43(2):253-64.
2007: Shangxi Liu; Shi-wen Xu; Laura Kennedy; Daphne Pala; Yunliang Chen; Mark Eastwood; David E Carter; Carol M Black; David J Abraham; Andrew Leask
FAK is required for TGFbeta-induced JNK phosphorylation in fibroblasts: implications for acquisition of a matrix-remodeling phenotype.
Molecular biology of the cell 2007;18(6):2169-78.
2007: Laura Kennedy; Shangxi Liu; Xu Shi-wen; Yunliang Chen; Mark Eastwood; Mojhgan Sabetkar; David E Carter; Karen M Lyons; Carol M Black; David J Abraham; Andrew Leask
CCN2 is necessary for the function of mouse embryonic fibroblasts.
Experimental cell research 2007;313(5):952-64.
2007: Michael R Dashwood; Audrey Dooley; Xu Shi-wen; David J Abraham; Domingos S R Souza
Does periadventitial fat-derived nitric oxide play a role in improved saphenous vein graft patency in patients undergoing coronary artery bypass surgery?
Journal of vascular research 2007;44(3):175-81.
2006: Vineeth Rajkumar; Xu Shiwen; Maria Bostrom; Patricia Leoni; John Muddle; Mikael Ivarsson; Bengt Gerdin; Christopher P Denton; George Bou-Gharios; Carol M Black; David J Abraham
Platelet-derived growth factor-beta receptor activation is essential for fibroblast and pericyte recruitment during cutaneous wound healing.
The American journal of pathology 2006;169(6):2254-65.
2006: Andrew Leask; David J Abraham
All in the CCN family: essential matricellular signaling modulators emerge from the bunker.
Journal of cell science 2006;119(Pt 23):4803-10.
2006: Teik K Ho; David J Abraham; Carol M Black; Daryll M Baker
Hypoxia-inducible factor 1 in lower limb ischemia.
Vascular 2006;14(6):321-7.
2006: Teik K Ho; Vineeth Rajkumar; Carol M Black; David J Abraham; Daryll M Baker
Increased angiogenic response but deficient arteriolization and abnormal microvessel ultrastructure in critical leg ischaemia.
The British journal of surgery 2006;93(11):1368-76.
2006: Xu Shi-wen; Fernando Rodríguez-Pascual; Santiago Lamas; holmes alan; Sarah Howat; Jeremy Pearson; Michael R Dashwood; Roland M Du Bois; Christopher P Denton; Carol M Black; David J Abraham; Andrew Leask
Constitutive ALK5-independent c-Jun N-terminal kinase activation contributes to endothelin-1 overexpression in pulmonary fibrosis: evidence of an autocrine endothelin loop operating through the endothelin A and B receptors.
Molecular and cellular biology 2006;26(14):5518-27.
2006: Audrey Dooley; Beirong Gao; NJ Bradley; David J Abraham; Carol M Black; Michael Jacobs; K Richard Bruckdorfer
Abnormal nitric oxide metabolism in systemic sclerosis: increased levels of nitrated proteins and asymmetric dimethylarginine.
Rheumatology (Oxford, England) 2006;45(6):676-84.
2006: Rajesh P Menon; Malini R Menon; Xu Shi-wen; Elisabetta A Renzoni; George Bou-Gharios; Carol M Black; David J Abraham
Hammerhead ribozyme-mediated silencing of the mutant fibrillin-1 of tight skin mouse: insight into the functional role of mutant fibrillin-1.
Experimental cell research 2006;312(9):1463-74.
2006: Xu Shi-wen; Lee-Anne Stanton; Laura Kennedy; Daphne Pala; Yunliang Chen; Sarah Howat; Elisabetta A Renzoni; David E Carter; George Bou-Gharios; Richard J Stratton; Jeremy Pearson; Frank Beier; Karen M Lyons; Carol M Black; David J Abraham; Andrew Leask
CCN2 is necessary for adhesive responses to transforming growth factor-beta1 in embryonic fibroblasts.
The Journal of biological chemistry 2006;281(16):10715-26.
2006: Yunliang Chen; Xu Shi-wen; Mark Eastwood; Carol M Black; Christopher P Denton; Andrew Leask; David J Abraham
Contribution of activin receptor-like kinase 5 (transforming growth factor beta receptor type I) signaling to the fibrotic phenotype of scleroderma fibroblasts.
Arthritis and rheumatism 2006;54(4):1309-16.
2006: Christopher P Denton; Carol M Black; David J Abraham
Mechanisms and consequences of fibrosis in systemic sclerosis.
Nature clinical practice. Rheumatology 2006;2(3):134-44.
2006: Charlotte E Waters; Xu Shi-wen; Christopher P Denton; David J Abraham; Jeremy Pearson
Signaling pathways regulating intercellular adhesion molecule 1 expression by endothelin 1: comparison with interleukin-1beta in normal and scleroderma dermal fibroblasts.
Arthritis and rheumatism 2006;54(2):649-60.
2006: Teik K Ho; Vineeth Rajkumar; Markella Ponticos; Patricia Leoni; Dame Carol M Black; David J Abraham; Daryll M Baker
Increased endogenous angiogenic response and hypoxia-inducible factor-1alpha in human critical limb ischemia.
Journal of vascular surgery 2006;43(1):125-33.
2005: Maria Teresa Carulli; Voon H Ong; Markella Ponticos; Xu Shiwen; David J Abraham; Carol M Black; Christopher P Denton
Chemokine receptor CCR2 expression by systemic sclerosis fibroblasts: evidence for autocrine regulation of myofibroblast differentiation.
Arthritis and rheumatism 2005;52(12):3772-82.
2005: Yunliang Chen; Xu Shi-wen; Jonathan van Beek; Laura Kennedy; Marilyn McLeod; Elisabetta A Renzoni; George Bou-Gharios; Sarah Wilcox-Adelman; Paul F Goetinck; Mark Eastwood; Carol M Black; David J Abraham; Andrew Leask
Matrix contraction by dermal fibroblasts requires transforming growth factor-beta/activin-linked kinase 5, heparan sulfate-containing proteoglycans, and MEK/ERK: insights into pathological scarring in chronic fibrotic disease.
The American journal of pathology 2005;167(6):1699-711.
2005: Magdalena Dziadzio; R E Smith; David J Abraham; Carol M Black; Christopher P Denton
Circulating levels of active transforming growth factor beta1 are reduced in diffuse cutaneous systemic sclerosis and correlate inversely with the modified Rodnan skin score.
Rheumatology (Oxford, England) 2005;44(12):1518-24.
2005: Michael R Dashwood; Kay Savage; Audrey Dooley; Xu Shi-wen; David J Abraham; Domingos S R Souza
Effect of vein graft harvesting on endothelial nitric oxide synthase and nitric oxide production.
The Annals of thoracic surgery 2005;80(3):939-44.
2005: Christopher P Denton; Gisela E Lindahl; Korsa Khan; Xu Shiwen; Voon H Ong; Nicholas J Gaspar; Konstantinos Lazaridis; Dylan R Edwards; Andrew Leask; Mark Eastwood; Patricia Leoni; Elisabetta A Renzoni; George Bou-Gharios; David J Abraham; Carol M Black
Activation of key profibrotic mechanisms in transgenic fibroblasts expressing kinase-deficient type II Transforming growth factor-{beta} receptor (T{beta}RII{delta}k).
The Journal of biological chemistry 2005;280(16):16053-65.
2005: Vineeth Rajkumar; Kevin Howell; Katalin Csiszar; Christopher P Denton; Carol M Black; David J Abraham
Shared expression of phenotypic markers in systemic sclerosis indicates a convergence of pericytes and fibroblasts to a myofibroblast lineage in fibrosis.
Arthritis research & therapy 2005;7(5):R1113-23.
2004: Yunliang Chen; David J Abraham; Xu Shi-wen; Jeremy Pearson; Carol M Black; Karen M Lyons; Andrew Leask
CCN2 (connective tissue growth factor) promotes fibroblast adhesion to fibronectin.
Molecular biology of the cell 2004;15(12):5635-46.
2004: Markella Ponticos; Terence A Partridge; Carol M Black; David J Abraham; George Bou-Gharios
Regulation of collagen type I in vascular smooth muscle cells by competition between Nkx2.5 and deltaEF1/ZEB1.
Molecular and cellular biology 2004;24(14):6151-61.
2004: Christopher P Denton; David J Abraham
Transgenic analysis of scleroderma: understanding key pathogenic events in vivo.
Autoimmunity reviews 2004;3(4):285-93.
2004: Xu Shi-wen; Yunliang Chen; Christopher P Denton; Mark Eastwood; Elisabetta A Renzoni; George Bou-Gharios; Jeremy Pearson; Michael R Dashwood; Roland M Du Bois; Carol M Black; Andrew Leask; David J Abraham
Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac/phosphoinositide 3-kinase/Akt-dependent pathway and is essential for the enhanced contractile phenotype of fibrotic fibroblasts.
Molecular biology of the cell 2004;15(6):2707-19.
2004: Shi-wen Xu; Sarah Howat; Elisabetta A Renzoni; holmes alan; Jeremy Pearson; Michael R Dashwood; George Bou-Gharios; Christopher P Denton; Roland M Du Bois; Carol M Black; Andrew Leask; David J Abraham
Endothelin-1 induces expression of matrix-associated genes in lung fibroblasts through MEK/ERK.
The Journal of biological chemistry 2004;279(22):23098-103.
2004: Magdalena Dziadzio; R E Smith; David J Abraham; R J Stratton; Armando Gabrielli; Carol M Black; Christopher P Denton
Serological assessment of type I collagen burden in scleroderma spectrum disorders: a systematic review.
Clinical and experimental rheumatology 2004;22(3):356-67.
2004: Andrew Leask; David J Abraham
TGF-beta signaling and the fibrotic response.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(7):816-27.
2004: Elisabetta A Renzoni; David J Abraham; Sarah Howat; Xu Shi-wen; Piersante Sestini; George Bou-Gharios; Athol U Wells; Srihari Veeraraghavan; Andrew G Nicholson; Christopher P Denton; Andrew Leask; Jeremy Pearson; Carol M Black; Kenneth I Welsh; Roland M Du Bois
Gene expression profiling reveals novel TGFbeta targets in adult lung fibroblasts.
Respiratory research 2004;5():24.
2004: Andrew Leask; Christopher P Denton; David J Abraham
Insights into the molecular mechanism of chronic fibrosis: the role of connective tissue growth factor in scleroderma.
The Journal of investigative dermatology 2004;122(1):1-6.
2003: holmes alan; David J Abraham; Youjun Chen; Christopher P Denton; Xu Shi-wen; Carol M Black; Andrew Leask
Constitutive connective tissue growth factor expression in scleroderma fibroblasts is dependent on Sp1.
The Journal of biological chemistry 2003;278(43):41728-33.
2003: Christopher P Denton; Bing Zheng; Lowri A Evans; Xu Shi-wen; Voon H Ong; Ivan B Fisher; Konstantinos Lazaridis; David J Abraham; Carol M Black; Benoit de Crombrugghe
Fibroblast-specific expression of a kinase-deficient type II transforming growth factor beta (TGFbeta) receptor leads to paradoxical activation of TGFbeta signaling pathways with fibrosis in transgenic mice.
The Journal of biological chemistry 2003;278(27):25109-19.
2003: Voon H Ong; Lowri A Evans; Xu Shiwen; Ivan B Fisher; Vineeth Rajkumar; David J Abraham; Carol M Black; Christopher P Denton
Monocyte chemoattractant protein 3 as a mediator of fibrosis: Overexpression in systemic sclerosis and the type 1 tight-skin mouse.
Arthritis and rheumatism 2003;48(7):1979-91.
2002: Richard Stratton; Vineeth Rajkumar; Markella Ponticos; Blake Nichols; Xu Shiwen; Carol M Black; David J Abraham; Andrew Leask
Prostacyclin derivatives prevent the fibrotic response to TGF-beta by inhibiting the Ras/MEK/ERK pathway.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(14):1949-51.
2002: Youjun Chen; Ingrid E Blom; Susan Sa; roel goldschmeding; David J Abraham; Andrew Leask
CTGF expression in mesangial cells: involvement of SMADs, MAP kinase, and PKC.
Kidney international 2002;62(4):1149-59.
2002: Andrew Leask; David J Abraham; D R Finlay; holmes alan; D Pennington; Xu Shi-wen; Y Chen; K Venstrom; X Dou; Markella Ponticos; C Black; C Bernabeu; J K Jackman; P R Findell; M Kari Connolly
Dysregulation of transforming growth factor beta signaling in scleroderma: overexpression of endoglin in cutaneous scleroderma fibroblasts.
Arthritis and rheumatism 2002;46(7):1857-65.
2002: Jennifer E Morgan; Jacqueline G Gross; Charles N Pagel; Jonathan R Beauchamp; Ariberto Fassati; Adrian J Thrasher; James P Di Santo; Ivan B Fisher; Xu Shiwen; David J Abraham; Terence A Partridge
Myogenic cell proliferation and generation of a reversible tumorigenic phenotype are triggered by preirradiation of the recipient site.
The Journal of cell biology 2002;157(4):693-702.
2002: Andrew Leask; holmes alan; David J Abraham
Connective tissue growth factor: a new and important player in the pathogenesis of fibrosis.
Current rheumatology reports 2002;4(2):136-42.
2001: Christopher P Denton; David J Abraham
Transforming growth factor-beta and connective tissue growth factor: key cytokines in scleroderma pathogenesis.
Current opinion in rheumatology 2001;13(6):505-11.
2001: Andrew Leask; Susan Sa; holmes alan; Xu Shiwen; C M Black; David J Abraham
The control of ccn2 (ctgf) gene expression in normal and scleroderma fibroblasts.
Molecular pathology : MP 2001;54(3):180-3.
2001: holmes alan; David J Abraham; Susan Sa; Xu Shiwen; Carol M Black; Andrew Leask
CTGF and SMADs, maintenance of scleroderma phenotype is independent of SMAD signaling.
The Journal of biological chemistry 2001;276(14):10594-601.
2001: Xu Shi-wen; Christopher P Denton; Michael R Dashwood; holmes alan; George Bou-Gharios; Jeremy Pearson; Carol M Black; David J Abraham
Fibroblast matrix gene expression and connective tissue remodeling: role of endothelin-1.
The Journal of investigative dermatology 2001;116(3):417-25.
2000: Xu Shi-wen; D Pennington; holmes alan; Andrew Leask; D Bradham; J R Beauchamp; Carmen Fonseca; Roland M Du Bois; G R Martin; Carol M Black; David J Abraham
Autocrine overexpression of CTGF maintains fibrosis: RDA analysis of fibrosis genes in systemic sclerosis.
Experimental cell research 2000;259(1):213-24.
2000: David J Abraham; Xu Shiwen; Carol M Black; Susan Sa; Y Xu; Andrew Leask
Tumor necrosis factor alpha suppresses the induction of connective tissue growth factor by transforming growth factor-beta in normal and scleroderma fibroblasts.
The Journal of biological chemistry 2000;275(20):15220-5.
1999: Vineeth Rajkumar; C Sundberg; David J Abraham; K Rubin; Carol M Black
Activation of microvascular pericytes in autoimmune Raynaud's phenomenon and systemic sclerosis.
Arthritis and rheumatism 1999;42(5):930-41.
1998: Shi-wen Xu; Christopher P Denton; Michael R Dashwood; David J Abraham; Carol M Black
Endothelin-1 regulation of intercellular adhesion molecule-1 expression in normal and sclerodermal fibroblasts.
Journal of cardiovascular pharmacology 1998;31 Suppl 1():S545-7.
1998: S Xu; Christopher P Denton; holmes alan; Michael R Dashwood; David J Abraham; Carol M Black
Endothelins: effect on matrix biosynthesis and proliferation in normal and scleroderma fibroblasts.
Journal of cardiovascular pharmacology 1998;31 Suppl 1():S360-3.
1997: David J Abraham; R Vancheeswaran; Michael R Dashwood; Vineeth Rajkumar; P Pantelides; Shi-wen Xu; Roland M Du Bois; Carol M Black
Increased levels of endothelin-1 and differential endothelin type A and B receptor expression in scleroderma-associated fibrotic lung disease.
The American journal of pathology 1997;151(3):831-41.
1997: Xu Shi-wen; Christopher P Denton; A McWhirter; George Bou-Gharios; David J Abraham; Roland M Du Bois; Carol M Black
Scleroderma lung fibroblasts exhibit elevated and dysregulated type I collagen biosynthesis.
Arthritis and rheumatism 1997;40(7):1237-44.
1992: Jonathan R Beauchamp; David J Abraham; George Bou-Gharios; Terence A Partridge; I Olsen
Expression and function of heterotypic adhesion molecules during differentiation of human skeletal muscle in culture.
The American journal of pathology 1992;140(2):387-401.
1991: David J Abraham; George Bou-Gharios; Jonathan R Beauchamp; C Plater-Zyberk; R N Maini; I Olsen
Function and regulation of the murine lymphocyte CD2 receptor.
Journal of leukocyte biology 1991;49(4):329-41.