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Douglas Andres

Research Profile

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TOP 3
Shawn M Crump; Douglas A Andres; Gail Sievert; Satin Jonathan
The cardiac L-type calcium channel distal carboxy terminus autoinhibition is regulated by calcium.
Weikang Cai; Jennifer L Rudolph; Tomoko Sengoku; Douglas A Andres
Rit GTPase regulates a p38 MAPK-dependent neuronal survival pathway.
Geng-Xian Shi; Weikang Cai; Douglas A Andres
Rit-mediated stress resistance involves a p38-mitogen- and stress-activated protein kinase 1 (MSK1)-dependent cAMP response element-binding protein (CREB) activation cascade.

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All Publications

2013: Shawn M Crump; Douglas A Andres; Gail Sievert; Satin Jonathan
The cardiac L-type calcium channel distal carboxy terminus autoinhibition is regulated by calcium.
American journal of physiology. Heart and circulatory physiology 2013;304(3):H455-64.
2012: Weikang Cai; Jennifer L Rudolph; Tomoko Sengoku; Douglas A Andres
Rit GTPase regulates a p38 MAPK-dependent neuronal survival pathway.
Neuroscience letters 2012;531(2):125-30.
2012: Geng-Xian Shi; Weikang Cai; Douglas A Andres
Rit-mediated stress resistance involves a p38-mitogen- and stress-activated protein kinase 1 (MSK1)-dependent cAMP response element-binding protein (CREB) activation cascade.
The Journal of biological chemistry 2012;287(47):39859-68.
2012: Thangaiah Subramanian; Yuta Suzuki; Jerry Troutman; Douglas A Andres; Carol A Fierke; Karunai Leela Subramanian; Suxia Liu; June E Pais; H Peter Spielmann
Farnesyl diphosphate analogues with aryl moieties are efficient alternate substrates for protein farnesyltransferase.
Biochemistry 2012;51(41):8307-19.
2012: Weikang Cai; Shaun W Carlson; Catherine E Mannon; Carole L Moncman; Kathryn E Saatman; Jennifer M Brelsfoard; Douglas A Andres
Rit GTPase signaling promotes immature hippocampal neuronal survival.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(29):9887-97.
2012: Janos Magyar; Steven Niederer; Geng-Xian Shi; Gail Sievert; Nic Smith; Douglas A Andres; Weikang Cai; Shawn M Crump; Carmen E Kiper; Liren Li; Satin Jonathan
Rem-GTPase regulates cardiac myocyte L-type calcium current.
Channels (Austin, Tex.) 2012;6(3):166-73.
2011: Weikang Cai; Aubrey L Frantz; Douglas A Harrison; Susan M W Harrison; Ling Jin; Jennifer L Rudolph; Douglas A Andres
An evolutionarily conserved Rit GTPase-p38 MAPK signaling pathway mediates oxidative stress resistance.
Molecular biology of the cell 2011;22(17):3231-41.
2011: Geng-Xian Shi; Douglas A Andres; Weikang Cai
Ras family small GTPase-mediated neuroprotective signaling in stroke.
Central nervous system agents in medicinal chemistry 2011;11(2):114-37.
2011: Geng-Xian Shi; Ling Jin; Douglas A Andres
A rit GTPase-p38 mitogen-activated protein kinase survival pathway confers resistance to cellular stress.
Molecular and cellular biology 2011;31(10):1938-48.
2010: Chunyan Pang; Shawn M Crump; Ling Jin; Robert N Correll; Brian S Finlin; Satin Jonathan; Douglas A Andres
Rem GTPase interacts with the proximal CaV1.2 C-terminus and modulates calcium-dependent channel inactivation.
Channels (Austin, Tex.) 2010;4(3):192-202.
2010: Geng-Xian Shi; Ling Jin; Douglas A Andres
Src-dependent TrkA transactivation is required for pituitary adenylate cyclase-activating polypeptide 38-mediated Rit activation and neuronal differentiation.
Molecular biology of the cell 2010;21(9):1597-608.
2008: Douglas A Andres; Geng-Xian Shi; Donald Bruun; Chris Barnhart; Pamela J Lein
Rit signaling contributes to interferon-gamma-induced dendritic retraction via p38 mitogen-activated protein kinase activation.
Journal of neurochemistry 2008;107(5):1436-47.
2008: Thangaiah Subramanian; Suxia Liu; Jerry Troutman; Douglas A Andres; H Peter Spielmann
Protein farnesyltransferase-catalyzed isoprenoid transfer to peptide depends on lipid size and shape, not hydrophobicity.
Chembiochem : a European journal of chemical biology 2008;9(17):2872-82.
2008: William C Lester; Elizabeth A Schroder; Don E Burgess; Doug Yozwiak; Douglas A Andres; Satin Jonathan
Steady-state coupling of plasma membrane calcium entry to extrusion revealed by novel L-type calcium channel block.
Cell calcium 2008;44(4):353-62.
2008: Geng-Xian Shi; Ling Jin; Douglas A Andres
Pituitary adenylate cyclase-activating polypeptide 38-mediated Rin activation requires Src and contributes to the regulation of HSP27 signaling during neuronal differentiation.
Molecular and cellular biology 2008;28(16):4940-51.
2008: Robert N Correll; Chunyan Pang; Dana M Niedowicz; Satin Jonathan; Douglas A Andres
Calmodulin binding is dispensable for Rem-mediated Ca2+ channel inhibition.
Molecular and cellular biochemistry 2008;310(1-2):103-10.
2008: Robert N Correll; Gregory J Botzet; Satin Jonathan; Douglas A Andres; Brian S Finlin
Analysis of the Rem2 - voltage dependant calcium channel beta subunit interaction and Rem2 interaction with phosphorylated phosphatidylinositide lipids.
Cellular signalling 2008;20(2):400-8.
2008: Robert N Correll; Chunyan Pang; Dana M Niedowicz; Brian S Finlin; Douglas A Andres
The RGK family of GTP-binding proteins: regulators of voltage-dependent calcium channels and cytoskeleton remodeling.
Cellular signalling 2008;20(2):292-300.
2007: Jennifer L Rudolph; Geng-Xian Shi; Eda Erdogan; Alan P Fields; Douglas A Andres
Rit mutants confirm role of MEK/ERK signaling in neuronal differentiation and reveal novel Par6 interaction.
Biochimica et biophysica acta 2007;1773(12):1793-800.
2007: Jerry Troutman; Douglas A Andres; H Peter Spielmann
Protein farnesyl transferase target selectivity is dependent upon peptide stimulated product release.
Biochemistry 2007;46(40):11299-309.
2007: Jerry Troutman; Thangaiah Subramanian; Douglas A Andres; H Peter Spielmann
Selective modification of CaaX peptides with ortho-substituted anilinogeranyl lipids by protein farnesyl transferase: competitive substrates and potent inhibitors from a library of farnesyl diphosphate analogues.
Biochemistry 2007;46(40):11310-21.
2007: Robert N Correll; Chunyan Pang; Brian S Finlin; Alexandria M Dailey; Satin Jonathan; Douglas A Andres
Plasma membrane targeting is essential for Rem-mediated Ca2+ channel inhibition.
The Journal of biological chemistry 2007;282(39):28431-40.
2007: Pamela J Lein; Xin Guo; Geng-Xian Shi; Melissa Moholt-Siebert; Donald Bruun; Douglas A Andres
The novel GTPase Rit differentially regulates axonal and dendritic growth.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(17):4725-36.
2007: Elizabeth A Schroder; János Magyar; Don Burgess; Douglas A Andres; Satin Jonathan
Chronic verapamil treatment remodels ICa,L in mouse ventricle.
American journal of physiology. Heart and circulatory physiology 2007;292(4):H1906-16.
2007: Thomas Dechat; Takeshi Shimi; Stephen Adam; Antonio Rusiñol; Douglas A Andres; H Peter Spielmann; Michael S Sinensky; Robert D Goldman
Alterations in mitosis and cell cycle progression caused by a mutant lamin A known to accelerate human aging.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(12):4955-60.
2006: Michael J Roberts; Jerry Troutman; Kareem A H Chehade; Hyuk C Cha; Joseph Kao; Xiaoqin Huang; Chang-Guo Zhan; Yuri K Peterson; Thangaiah Subramanian; Srinivasan Kamalakkannan; Douglas A Andres; H Peter Spielmann
Hydrophilic anilinogeranyl diphosphate prenyl analogues are Ras function inhibitors.
Biochemistry 2006;45(51):15862-72.
2006: Geng-Xian Shi; Holger Rehmann; Douglas A Andres
A novel cyclic AMP-dependent Epac-Rit signaling pathway contributes to PACAP38-mediated neuronal differentiation.
Molecular and cellular biology 2006;26(23):9136-47.
2006: Shawn M Crump; Robert N Correll; Elizabeth A Schroder; William C Lester; Brian S Finlin; Douglas A Andres; Satin Jonathan
L-type calcium channel alpha-subunit and protein kinase inhibitors modulate Rem-mediated regulation of current.
American journal of physiology. Heart and circulatory physiology 2006;291(4):H1959-71.
2006: Brian S Finlin; Robert N Correll; Chunyan Pang; Shawn M Crump; Satin Jonathan; Douglas A Andres
Analysis of the complex between Ca2+ channel beta-subunit and the Rem GTPase.
The Journal of biological chemistry 2006;281(33):23557-66.
2006: Douglas A Andres; Jennifer L Rudolph; Tomoko Sengoku; Geng-Xian Shi
Analysis of Rit signaling and biological activity.
Methods in enzymology 2006;407():499-512.
2006: Douglas A Andres; Shawn M Crump; Robert N Correll; Satin Jonathan; Brian S Finlin
Analyses of Rem/RGK signaling and biological activity.
Methods in enzymology 2006;407():484-98.
2005: Brian S Finlin; Amber L Mosley; Shawn M Crump; Robert N Correll; Sabire Ozcan; Satin Jonathan; Douglas A Andres
Regulation of L-type Ca2+ channel activity and insulin secretion by the Rem2 GTPase.
The Journal of biological chemistry 2005;280(51):41864-71.
2005: Geng-Xian Shi; Jiahuai Han; Douglas A Andres
Rin GTPase couples nerve growth factor signaling to p38 and b-Raf/ERK pathways to promote neuronal differentiation.
The Journal of biological chemistry 2005;280(45):37599-609.
2005: Jerry Troutman; Michael J Roberts; Douglas A Andres; H Peter Spielmann
Tools to analyze protein farnesylation in cells.
Bioconjugate chemistry 2005;16(5):1209-17.
2005: Thangaiah Subramanian; Zhongwen Wang; Jerry Troutman; Douglas A Andres; H Peter Spielmann
Directed library of anilinogeranyl analogues of farnesyl diphosphate via mixed solid- and solution-phase synthesis.
Organic letters 2005;7(11):2109-12.
2005: Susan M W Harrison; Jennifer L Rudolph; Michael L Spencer; Paul D Wes; Craig Montell; Douglas A Andres; Douglas A Harrison
Activated RIC, a small GTPase, genetically interacts with the Ras pathway and calmodulin during Drosophila development.
Developmental dynamics : an official publication of the American Association of Anatomists 2005;232(3):817-26.
2005: Geng-Xian Shi; Douglas A Andres
Rit contributes to nerve growth factor-induced neuronal differentiation via activation of B-Raf-extracellular signal-regulated kinase and p38 mitogen-activated protein kinase cascades.
Molecular and cellular biology 2005;25(2):830-46.
2004: Jerry Troutman; Kareem A H Chehade; Katarzyna Kiegiel; Douglas A Andres; H Peter Spielmann
Synthesis of acyloxymethyl ester prodrugs of the transferable protein farnesyl transferase substrate farnesyl methylenediphosphonate.
Bioorganic & medicinal chemistry letters 2004;14(19):4979-82.
2004: Douglas A Andres
Nonradioactive methods for detecting activation of Ras-related small G proteins.
Methods in molecular biology (Clifton, N.J.) 2004;284():163-73.
2003: Brian S Finlin; Shawn M Crump; Satin Jonathan; Douglas A Andres
Regulation of voltage-gated calcium channel activity by the Rem and Rad GTPases.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(24):14469-74.
2003: Dianna L Hynds; Michael L Spencer; Douglas A Andres; Diane M Snow
Rit promotes MEK-independent neurite branching in human neuroblastoma cells.
Journal of cell science 2003;116(Pt 10):1925-35.
2002: Kareem A H Chehade; Katarzyna Kiegiel; Richard J Isaacs; Jennifer S Pickett; Katherine E Bowers; Carol A Fierke; Douglas A Andres; H Peter Spielmann
Photoaffinity analogues of farnesyl pyrophosphate transferable by protein farnesyl transferase.
Journal of the American Chemical Society 2002;124(28):8206-19.
2002: Michael L Spencer; Haipeng Shao; Douglas A Andres
Induction of neurite extension and survival in pheochromocytoma cells by the Rit GTPase.
The Journal of biological chemistry 2002;277(23):20160-8.
2002: Michael L Spencer; Haipeng Shao; H Michael Tucker; Douglas A Andres
Nerve growth factor-dependent activation of the small GTPase Rin.
The Journal of biological chemistry 2002;277(20):17605-15.
2001: Brian S Finlin; Chia-Ling Gau; G A Murphy; Haipeng Shao; T Kimel; R S Seitz; Yen-Feng Chiu; D Botstein; P O Brown; Channing J Der; Fuyuhiko Tamanoi; Douglas A Andres; Charles M Perou
RERG is a novel ras-related, estrogen-regulated and growth-inhibitory gene in breast cancer.
The Journal of biological chemistry 2001;276(45):42259-67.
2001: E Micali; Kareem A H Chehade; Richard J Isaacs; Douglas A Andres; H Peter Spielmann
Protein farnesyltransferase isoprenoid substrate discrimination is dependent on isoprene double bonds and branched methyl groups.
Biochemistry 2001;40(41):12254-65.
2001: C Than; H Morimoto; P G Williams; Kareem A H Chehade; Douglas A Andres; H Peter Spielmann
Preparation, NMR characterization, and labeling reactions of tritiated triacetoxy sodium borohydride.
The Journal of organic chemistry 2001;66(10):3602-5.
2001: Douglas A Andres
Expression cloning to identify monomeric GTP-binding proteins by GTP overlay.
Methods in enzymology 2001;332():203-10.
2001: Douglas A Andres
Expression cloning of farnesylated proteins.
Methods in enzymology 2001;332():195-202.
2000: Haipeng Shao; Douglas A Andres
A novel RalGEF-like protein, RGL3, as a candidate effector for rit and Ras.
The Journal of biological chemistry 2000;275(35):26914-24.
2000: Kareem A H Chehade; Douglas A Andres; H Morimoto; H Peter Spielmann
Design and synthesis of a transferable farnesyl pyrophosphate analogue to Ras by protein farnesyltransferase.
The Journal of organic chemistry 2000;65(10):3027-33.
2000: Brian S Finlin; Haipeng Shao; K Kadono-Okuda; N Guo; Douglas A Andres
Rem2, a new member of the Rem/Rad/Gem/Kir family of Ras-related GTPases.
The Biochemical journal 2000;347 Pt 1():223-31.
1999: Haipeng Shao; K Kadono-Okuda; Brian S Finlin; Douglas A Andres
Biochemical characterization of the Ras-related GTPases Rit and Rin.
Archives of biochemistry and biophysics 1999;371(2):207-19.
1999: Brian S Finlin; Douglas A Andres
Phosphorylation-dependent association of the Ras-related GTP-binding protein Rem with 14-3-3 proteins.
Archives of biochemistry and biophysics 1999;368(2):401-12.
1999: Douglas A Andres; Dean Crick; Brian S Finlin; Charles J Waechter
Rapid identification of cysteine-linked isoprenyl groups by metabolic labeling with [3H]farnesol and [3H]geranylgeraniol.
Methods in molecular biology (Clifton, N.J.) 1999;116():107-23.
1998: Dean Crick; Douglas A Andres; R Danesi; Marco Macchia; Charles J Waechter
Geranylgeraniol overcomes the block of cell proliferation by lovastatin in C6 glioma cells.
Journal of neurochemistry 1998;70(6):2397-405.
1997: K Kadono-Okuda; Douglas A Andres
An expression cloning method to identify monomeric GTP-binding proteins by GTP overlay.
Analytical biochemistry 1997;254(2):187-91.
1997: Douglas A Andres; Haipeng Shao; Dean Crick; Brian S Finlin
Expression cloning of a novel farnesylated protein, RDJ2, encoding a DnaJ protein homologue.
Archives of biochemistry and biophysics 1997;346(1):113-24.
1997: Brian S Finlin; Douglas A Andres
Rem is a new member of the Rad- and Gem/Kir Ras-related GTP-binding protein family repressed by lipopolysaccharide stimulation.
The Journal of biological chemistry 1997;272(35):21982-8.
1997: Dean Crick; Douglas A Andres; Charles J Waechter
Novel salvage pathway utilizing farnesol and geranylgeraniol for protein isoprenylation.
Biochemical and biophysical research communications 1997;237(3):483-7.
1997: Dean Crick; Douglas A Andres; Charles J Waechter
Geranylgeraniol promotes entry of UT-2 cells into the cell cycle in the absence of mevalonate.
Experimental cell research 1997;231(2):302-7.
1996: Dean Crick; Charles J Waechter; Douglas A Andres
Geranylgeraniol restores cell proliferation to lovastatin treated C6 glial cells.
SAAS bulletin, biochemistry and biotechnology 1996;9():37-42.
1995: Dean Crick; J Suders; C M Kluthe; Douglas A Andres; Charles J Waechter
Selective inhibition of cholesterol biosynthesis in brain cells by squalestatin 1.
Journal of neurochemistry 1995;65(3):1365-73.
1995: Dean Crick; Douglas A Andres; Charles J Waechter
Farnesol is utilized for protein isoprenylation and the biosynthesis of cholesterol in mammalian cells.
Biochemical and biophysical research communications 1995;211(2):590-9.
1994: Dean Crick; Charles J Waechter; Douglas A Andres
Utilization of geranylgeraniol for protein isoprenylation in C6 glial cells.
Biochemical and biophysical research communications 1994;205(1):955-61.