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Olivier Fardel

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Elise Kolasa; Noemie Houlbert; Patrick Balaguer; Olivier Fardel
AhR- and NF-κB-dependent induction of interleukin-6 by co-exposure to the environmental contaminant benzanthracene and the cytokine tumor necrosis factor-α in human mammary MCF-7 cells.
Marc Le Vee; Bruno Stieger; Elodie Jouan; Olivier Fardel
Differential regulation of drug transporter expression by all-trans retinoic acid in hepatoma HepaRG cells and human hepatocytes.
Olivier Fardel
Cytokines as molecular targets for aryl hydrocarbon receptor ligands: implications for toxicity and xenobiotic detoxification.

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2013: Elise Kolasa; Noemie Houlbert; Patrick Balaguer; Olivier Fardel
AhR- and NF-κB-dependent induction of interleukin-6 by co-exposure to the environmental contaminant benzanthracene and the cytokine tumor necrosis factor-α in human mammary MCF-7 cells.
Chemico-biological interactions 2013;203(2):391-400.
2013: Marc Le Vee; Bruno Stieger; Elodie Jouan; Olivier Fardel
Differential regulation of drug transporter expression by all-trans retinoic acid in hepatoma HepaRG cells and human hepatocytes.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2013;48(4-5):767-74.
2013: Olivier Fardel
Cytokines as molecular targets for aryl hydrocarbon receptor ligands: implications for toxicity and xenobiotic detoxification.
Expert opinion on drug metabolism & toxicology 2013;9(2):141-52.
2013: Mélinda Macoch; Claudie Morzadec; Olivier Fardel; Laurent Vernhet
Inorganic arsenic impairs differentiation and functions of human dendritic cells.
Toxicology and applied pharmacology 2013;266(2):204-13.
2013: Marie Jaguin; Olivier Fardel; Noémie Houlbert; Valérie Lecureur
Polarization profiles of human M-CSF-generated macrophages and comparison of M1-markers in classically activated macrophages from GM-CSF and M-CSF origin.
Cellular immunology 2013;281(1):51-61.
2012: Claudie Morzadec; Fidaa Bouezzedine; Olivier Fardel; Mélinda Macoch; Laurent Vernhet
Inorganic arsenic impairs proliferation and cytokine expression in human primary T lymphocytes.
Toxicology 2012;300(1-2):46-56.
2012: Elise Kolasa; Noémie Houlbert; Patrick Balaguer; Olivier Fardel
Phorbol ester-modulation of estrogenic genomic effects triggered by the environmental contaminant benzanthracene.
Toxicology in vitro : an international journal published in association with BIBRA 2012;26(6):807-16.
2012: Abdullah Mayati; Dominique Lagadic-Gossmann; Eric Le Ferrec; Olivier Fardel
Aryl hydrocarbon receptor-independent up-regulation of intracellular calcium concentration by environmental polycyclic aromatic hydrocarbons in human endothelial HMEC-1 cells.
Environmental toxicology 2012;27(9):556-62.
2012: Claudie Morzadec; Marc Robineau; Lydie Sparfel; Olivier Fardel; Mélinda Macoch; Laurent Vernhet
Inorganic arsenic represses interleukin-17A expression in human activated Th17 lymphocytes.
Toxicology and applied pharmacology 2012;262(3):217-22.
2012: Abdullah Mayati; Monique N'diaye; Hervé Paris; Philippe Uriac; Arnaud Courtois; Olivier Fardel; Dominique Lagadic-Gossmann; Nicolas Levoin; Eric Le Ferrec
Induction of intracellular calcium concentration by environmental benzo(a)pyrene involves a β2-adrenergic receptor/adenylyl cyclase/Epac-1/inositol 1,4,5-trisphosphate pathway in endothelial cells.
The Journal of biological chemistry 2012;287(6):4041-52.
2011: Amélie Moreau; Yannick Parmentier; Elodie Jouan; Marc Le Vee; Olivier Fardel
Drug transporter expression in human macrophages.
Fundamental & clinical pharmacology 2011;25(6):743-52.
2011: Marie-Laure Pinel-Marie; Sophie Desmots; Olivier Fardel; Laetitia Louarn; Lydie Sparfel
Aryl hydrocarbon receptor-dependent induction of the IgA receptor FcαRI by the environmental contaminant benzo(a)pyrene in human macrophages.
Toxicology 2011;290(1):89-95.
2011: N Podechard; Mickael Rialland; Vincent Rioux; Xavier Tekpli; Daniel Catheline; Olivier Fardel; Jørn Holme; Dominique Lagadic-Gossmann; Philippe Legrand; Valérie Lecureur
Mechanisms involved in lipid accumulation and apoptosis induced by 1-nitropyrene in Hepa1c1c7 cells.
Toxicology letters 2011;206(3):289-99.
2011: Emilie Bourdonnay; Olivier Fardel; Claudie Morzadec; Laurent Vernhet
Arsenic increases lipopolysaccharide-dependent expression of interleukin-8 gene by stimulating a redox-sensitive pathway that strengthens p38-kinase activation.
Molecular immunology 2011;48(15-16):2069-78.
2011: Marc Le Vee; Valérie Lecureur; Bruno Stieger; Elodie Jouan; Olivier Fardel
Regulation of drug transporter expression by oncostatin M in human hepatocytes.
Biochemical pharmacology 2011;82(3):304-11.
2011: Corinne Martin-Chouly; Claudie Morzadec; Mélodie Bonvalet; Marie-Dominique Galibert; Olivier Fardel; Laurent Vernhet
Inorganic arsenic alters expression of immune and stress response genes in activated primary human T lymphocytes.
Molecular immunology 2011;48(6-7):956-65.
2011: Alexandre R R Péry; Céline Brochot; Sophie Desmots; Magali Boize; Lydie Sparfel; Olivier Fardel
Predicting in vivo gene expression in macrophages after exposure to benzo(a)pyrene based on in vitro assays and toxicokinetic/toxicodynamic models.
Toxicology letters 2011;201(1):8-14.
2011: Marc Le Vee; Elodie Jouan; Amélie Moreau; Olivier Fardel
Regulation of drug transporter mRNA expression by interferon-γ in primary human hepatocytes.
Fundamental & clinical pharmacology 2011;25(1):99-103.
2011: David Gilot; Nolwenn Le Meur; Fanny Giudicelli; Marc Le Vée; Dominique Lagadic-Gossmann; Nathalie Théret; Olivier Fardel
RNAi-based screening identifies kinases interfering with dioxin-mediated up-regulation of CYP1A1 activity.
PloS one 2011;6(3):e18261.
2010: David Gilot; Fanny Giudicelli; Dominique Lagadic-Gossmann; Olivier Fardel
Akti-1/2, an allosteric inhibitor of Akt 1 and 2, efficiently inhibits CaMKIα activity and aryl hydrocarbon receptor pathway.
Chemico-biological interactions 2010;188(3):546-52.
2010: Marc Le Vee; Elodie Jouan; Olivier Fardel
Involvement of aryl hydrocarbon receptor in basal and 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced expression of target genes in primary human hepatocytes.
Toxicology in vitro : an international journal published in association with BIBRA 2010;24(6):1775-81.
2010: Lydie Sparfel; Marie-Laure Pinel-Marie; Magali Boize; Serge Koscielny; Sophie Desmots; Alexandre Pery; Olivier Fardel
Transcriptional signature of human macrophages exposed to the environmental contaminant benzo(a)pyrene.
Toxicological sciences : an official journal of the Society of Toxicology 2010;114(2):247-59.
2009: Olivier Fardel; Marc Le Vée
Regulation of human hepatic drug transporter expression by pro-inflammatory cytokines.
Expert opinion on drug metabolism & toxicology 2009;5(12):1469-81.
2009: Marc Le Vee; Valérie Lecureur; Amélie Moreau; Bruno Stieger; Olivier Fardel
Differential regulation of drug transporter expression by hepatocyte growth factor in primary human hepatocytes.
Drug metabolism and disposition: the biological fate of chemicals 2009;37(11):2228-35.
2009: Marie-Laure Pinel-Marie; Lydie Sparfel; Sophie Desmots; Olivier Fardel
Aryl hydrocarbon receptor-dependent induction of the NADPH oxidase subunit NCF1/p47 phox expression leading to priming of human macrophage oxidative burst.
Free radical biology & medicine 2009;47(6):825-34.
2009: Normand Podechard; Olivier Fardel; Michel Corolleur; Marc Bernard; Valérie Lecureur
Inhibition of human mesenchymal stem cell-derived adipogenesis by the environmental contaminant benzo(a)pyrene.
Toxicology in vitro : an international journal published in association with BIBRA 2009;23(6):1139-44.
2009: Emilie Bourdonnay; Claudie Morzadec; Olivier Fardel; Laurent Vernhet
Redox-sensitive regulation of gene expression in human primary macrophages exposed to inorganic arsenic.
Journal of cellular biochemistry 2009;107(3):537-47.
2009: Normand Podechard; Eric Le Ferrec; Amélie Rebillard; Olivier Fardel; Valérie Lecureur
NPC1 repression contributes to lipid accumulation in human macrophages exposed to environmental aryl hydrocarbons.
Cardiovascular research 2009;82(2):361-70.
2009: Monique N'diaye; Eric Le Ferrec; Florian Kronenberg; Hans Dieplinger; Marc Le Vee; Olivier Fardel
TNFalpha- and NF-kappaB-dependent induction of the chemokine CCL1 in human macrophages exposed to the atherogenic lipoprotein(a).
Life sciences 2009;84(13-14):451-7.
2009: Marc Le Vee; Valérie Lecureur; Bruno Stieger; Olivier Fardel
Regulation of drug transporter expression in human hepatocytes exposed to the proinflammatory cytokines tumor necrosis factor-alpha or interleukin-6.
Drug metabolism and disposition: the biological fate of chemicals 2009;37(3):685-93.
2009: Emilie Bourdonnay; Claudie Morzadec; Lydie Sparfel; Marie-Dominique Galibert; Stéphane Jouneau; Corinne Martin-Chouly; Olivier Fardel; Laurent Vernhet
Global effects of inorganic arsenic on gene expression profile in human macrophages.
Molecular immunology 2009;46(4):649-56.
2008: Patricia Monteiro; David Gilot; Sophie Langouet; Olivier Fardel
Activation of the aryl hydrocarbon receptor by the calcium/calmodulin-dependent protein kinase kinase inhibitor 7-oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid (STO-609).
Drug metabolism and disposition: the biological fate of chemicals 2008;36(12):2556-63.
2008: anthony lemarie; Emilie Bourdonnay; Claudie Morzadec; Olivier Fardel; Laurent Vernhet
Inorganic arsenic activates reduced NADPH oxidase in human primary macrophages through a Rho kinase/p38 kinase pathway.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(9):6010-7.
2008: Morgane Gorria; Xavier Tekpli; Mary Rissel; Odile Sergent; Laurence Huc; Nina Landvik; Olivier Fardel; Marie-Thérèse Dimanche-Boitrel; Jørn Holme; Dominique Lagadic-Gossmann
A new lactoferrin- and iron-dependent lysosomal death pathway is induced by benzo[a]pyrene in hepatic epithelial cells.
Toxicology and applied pharmacology 2008;228(2):212-24.
2008: Laurent Vernhet; Claudie Morzadec; Julien van Grevenynghe; Benoît Bareau; Michel Corolleur; Thierry Fest; Olivier Fardel
Inorganic arsenic induces necrosis of human CD34-positive haematopoietic stem cells.
Environmental toxicology 2008;23(2):263-8.
2008: Normand Podechard; Valérie Lecureur; Eric Le Ferrec; Isabelle Guenon; Lydie Sparfel; David Gilot; John R. Gordon; Vincent Lagente; Olivier Fardel
Interleukin-8 induction by the environmental contaminant benzo(a)pyrene is aryl hydrocarbon receptor-dependent and leads to lung inflammation.
Toxicology letters 2008;177(2):130-7.
2008: Patricia Monteiro; David Gilot; Eric Le Ferrec; Claudine Rauch; Dominique Lagadic-Gossmann; Olivier Fardel
Dioxin-mediated up-regulation of aryl hydrocarbon receptor target genes is dependent on the calcium/calmodulin/CaMKIalpha pathway.
Molecular pharmacology 2008;73(3):769-77.
2008: Marc Le Vee; Philippe Gripon; Bruno Stieger; Olivier Fardel
Down-regulation of organic anion transporter expression in human hepatocytes exposed to the proinflammatory cytokine interleukin 1beta.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(2):217-22.
2007: Nathalie Maubon; Marc Le Vee; Lina Fossati; Mathilde Audry; Eric Le Ferrec; Sebastien Bolze; Olivier Fardel
Analysis of drug transporter expression in human intestinal Caco-2 cells by real-time PCR.
Fundamental & clinical pharmacology 2007;21(6):659-63.
2007: Patricia Monteiro; David Gilot; Eric Le Ferrec; Valérie Lecureur; Monique N'diaye; Marc Le Vee; Normand Podechard; Celio Pouponnot; Olivier Fardel
AhR- and c-maf-dependent induction of beta7-integrin expression in human macrophages in response to environmental polycyclic aromatic hydrocarbons.
Biochemical and biophysical research communications 2007;358(2):442-8.
2007: Jørn Holme; Morgane Gorria; Volker M Arlt; Steinar Øvrebø; Anita Solhaug; Xavier Tekpli; Nina E Landvik; Laurence Huc; Olivier Fardel; Dominique Lagadic-Gossmann
Different mechanisms involved in apoptosis following exposure to benzo[a]pyrene in F258 and Hepa1c1c7 cells.
Chemico-biological interactions 2007;167(1):41-55.
2006: Emilie Jigorel; Marc Le Vee; Claire Boursier-Neyret; Yannick Parmentier; Olivier Fardel
Differential regulation of sinusoidal and canalicular hepatic drug transporter expression by xenobiotics activating drug-sensing receptors in primary human hepatocytes.
Drug metabolism and disposition: the biological fate of chemicals 2006;34(10):1756-63.
2006: anthony lemarie; Claudie Morzadec; Emilie Bourdonnay; Olivier Fardel; Laurent Vernhet
Human macrophages constitute targets for immunotoxic inorganic arsenic.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(5):3019-27.
2006: Monique N'diaye; Eric Le Ferrec; Dominique Lagadic-Gossmann; Sébastien Corre; David Gilot; Valérie Lecureur; Patricia Monteiro; Claudine Rauch; Marie-Dominique Galibert; Olivier Fardel
Aryl hydrocarbon receptor- and calcium-dependent induction of the chemokine CCL1 by the environmental contaminant benzo[a]pyrene.
The Journal of biological chemistry 2006;281(29):19906-15.
2006: Martine Escoffre-Barbe; Laurence Amiot; Pascale Beaucournu; Patrick Jego; Isabelle Grulois; Bernard Grosbois; Marc Bernard; Thierry Fest; Thierry Lamy; Olivier Fardel
Spontaneous megakaryocytic colony formation does not discriminate between essential thrombocythemia and polycythemia vera.
American journal of hematology 2006;81(7):554-6.
2006: Marc Le Vee; Emilie Jigorel; Denise Glaise; Philippe Gripon; Christiane Guguen-Guillouzo; Olivier Fardel
Functional expression of sinusoidal and canalicular hepatic drug transporters in the differentiated human hepatoma HepaRG cell line.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2006;28(1-2):109-17.
2006: Julien van Grevenynghe; Patricia Monteiro; David Gilot; Thierry Fest; Olivier Fardel
Human endothelial progenitors constitute targets for environmental atherogenic polycyclic aromatic hydrocarbons.
Biochemical and biophysical research communications 2006;341(3):763-9.
2006: Lydie Sparfel; Julien van Grevenynghe; Marc Le Vee; Caroline Aninat; Olivier Fardel
Potent inhibition of carcinogen-bioactivating cytochrome P450 1B1 by the p53 inhibitor pifithrin alpha.
Carcinogenesis 2006;27(3):656-63.
2006: anthony lemarie; Claudie Morzadec; Delphine Mérino; Olivier Micheau; Olivier Fardel; Laurent Vernhet
Arsenic trioxide induces apoptosis of human monocytes during macrophagic differentiation through nuclear factor-kappaB-related survival pathway down-regulation.
The Journal of pharmacology and experimental therapeutics 2006;316(1):304-14.
2005: David Gilot; Anne-Laure Serandour; Gennady Ilyin; Dominique Lagadic-Gossmann; Pascal Loyer; Anne Corlu; Alexandre Coutant; Georges Baffet; Marcus E Peter; Olivier Fardel; Christiane Guguen-Guillouzo
A role for caspase-8 and c-FLIPL in proliferation and cell-cycle progression of primary hepatocytes.
Carcinogenesis 2005;26(12):2086-94.
2005: Emilie Jigorel; Marc Le Vee; Claire Boursier-Neyret; Marc Bertrand; Olivier Fardel
Functional expression of sinusoidal drug transporters in primary human and rat hepatocytes.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(10):1418-22.
2005: Julien van Grevenynghe; Marc Bernard; S Langouet; C Le Berre; Thierry Fest; Olivier Fardel
Human CD34-positive hematopoietic stem cells constitute targets for carcinogenic polycyclic aromatic hydrocarbons.
The Journal of pharmacology and experimental therapeutics 2005;314(2):693-702.
2005: Olivier Fardel; Emilie Jigorel; Marc Le Vee; Léa Payen
Physiological, pharmacological and clinical features of the multidrug resistance protein 2.
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 2005;59(3):104-14.
2005: Valérie Lecureur; Eric Le Ferrec; Monique N'diaye; Marc Le Vee; Claire Gardyn; David Gilot; Olivier Fardel
ERK-dependent induction of TNFalpha expression by the environmental contaminant benzo(a)pyrene in primary human macrophages.
FEBS letters 2005;579(9):1904-10.
2004: anthony lemarie; Dominique Lagadic-Gossmann; Claudie Morzadec; Nathalie Allain; Olivier Fardel; Laurent Vernhet
Cadmium induces caspase-independent apoptosis in liver Hep3B cells: role for calcium in signaling oxidative stress-related impairment of mitochondria and relocation of endonuclease G and apoptosis-inducing factor.
Free radical biology & medicine 2004;36(12):1517-31.
2004: Julien van Grevenynghe; Lydie Sparfel; Marc Le Vee; David Gilot; Bernard Drenou; Renée Fauchet; Olivier Fardel
Cytochrome P450-dependent toxicity of environmental polycyclic aromatic hydrocarbons towards human macrophages.
Biochemical and biophysical research communications 2004;317(3):708-16.
2004: Lydie Sparfel; Laurence Huc; Marc Le Vee; Mireille Desille; Dominique Lagadic-Gossmann; Olivier Fardel
Inhibition of carcinogen-bioactivating cytochrome P450 1 isoforms by amiloride derivatives.
Biochemical pharmacology 2004;67(9):1711-9.
2004: Laurence Huc; Lydie Sparfel; Mary Rissel; Marie-Thérèse Dimanche-Boitrel; André Guillouzo; Olivier Fardel; Dominique Lagadic-Gossmann
Identification of Na+/H+ exchange as a new target for toxic polycyclic aromatic hydrocarbons.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(2):344-6.
2003: Laurence Huc; David Gilot; Claire Gardyn; Mary Rissel; Marie-Thérèse Dimanche-Boitrel; André Guillouzo; Olivier Fardel; Dominique Lagadic-Gossmann
Apoptotic mitochondrial dysfunction induced by benzo(a)pyrene in liver epithelial cells: role of p53 and pHi changes.
Annals of the New York Academy of Sciences 2003;1010():167-70.
2003: Gaëlle Le Friec; Béatrice Laupèze; Olivier Fardel; Yasmine Sebti; Céline Pangault; Valérie Guilloux; Alain Beauplet; Renée Fauchet; Laurence Amiot
Soluble HLA-G inhibits human dendritic cell-triggered allogeneic T-cell proliferation without altering dendritic differentiation and maturation processes.
Human immunology 2003;64(8):752-61.
2003: Julien van Grevenynghe; Sophie Rion; Eric Le Ferrec; Marc Le Vee; Laurence Amiot; Renée Fauchet; Olivier Fardel
Polycyclic aromatic hydrocarbons inhibit differentiation of human monocytes into macrophages.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(5):2374-81.
2003: Lydie Sparfel; Léa Payen; David Gilot; James Sidaway; Fabrice MOREL; André Guillouzo; Olivier Fardel
Pregnane X receptor-dependent and -independent effects of 2-acetylaminofluorene on cytochrome P450 3A23 expression and liver cell proliferation.
Biochemical and biophysical research communications 2003;300(2):278-84.
2003: Laurent Vernhet; Nathalie Allain; Marc Le Vée; Fabrice MOREL; André Guillouzo; Olivier Fardel
Blockage of multidrug resistance-associated proteins potentiates the inhibitory effects of arsenic trioxide on CYP1A1 induction by polycyclic aromatic hydrocarbons.
The Journal of pharmacology and experimental therapeutics 2003;304(1):145-55.
2002: Valérie Lecureur; Aurélien Le Thiec; Alexandre Le Meur; Laurence Amiot; Bernard Drenou; Marc Bernard; Thierry Lamy; Renée Fauchet; Olivier Fardel
Potassium antimonyl tartrate induces caspase- and reactive oxygen species-dependent apoptosis in lymphoid tumoral cells.
British journal of haematology 2002;119(3):608-15.
2002: Olivier Fardel; Léa Payen; Lydie Sparfel; Laurent Vernhet; Valérie Lecureur
[Drug membrane transporters in the liver: regulation of their expression and activity].
Annales pharmaceutiques françaises 2002;60(6):380-5.
2002: Bernard Drénou; Olivier Fardel; Renée Fauchet; Laurence Amiot
[Flow cytometry: application for the diagnosis and the follow-up of hematological malignancies].
Annales de biologie clinique 2002;60(6):663-72.
2002: Valérie Lecureur; Dominique Lagadic-Gossmann; Olivier Fardel
Potassium antimonyl tartrate induces reactive oxygen species-related apoptosis in human myeloid leukemic HL60 cells.
International journal of oncology 2002;20(5):1071-6.
2002: Lydie Sparfel; Maud Loewert; Laurence Huc; Léa Payen; André Guillouzo; Dominique Lagadic-Gossmann; Olivier Fardel
Acute cytotoxicity of the chemical carcinogen 2-acetylaminofluorene in cultured rat liver epithelial cells.
Toxicology letters 2002;129(3):245-54.
2002: Béatrice Laupeze; Laurence Amiot; Lydie Sparfel; Eric Le Ferrec; Renée Fauchet; Olivier Fardel
Polycyclic aromatic hydrocarbons affect functional differentiation and maturation of human monocyte-derived dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(6):2652-8.
2002: Béatrice Laupeze; Laurence Amiot; Bernard Drenou; Marc Bernard; Bernard Branger; Jean-Marc Grosset; Thierry Lamy; Renée Fauchet; Olivier Fardel
High multidrug resistance protein activity in acute myeloid leukaemias is associated with poor response to chemotherapy and reduced patient survival.
British journal of haematology 2002;116(4):834-8.
2002: Arnaud Courtois; Léa Payen; Eric Le Ferrec; George L Scheffer; Yolande Trinquart; André Guillouzo; Olivier Fardel
Differential regulation of multidrug resistance-associated protein 2 (MRP2) and cytochromes P450 2B1/2 and 3A1/2 in phenobarbital-treated hepatocytes.
Biochemical pharmacology 2002;63(2):333-41.
2002: Léa Payen; Lydie Sparfel; Arnaud Courtois; Laurent Vernhet; André Guillouzo; Olivier Fardel
The drug efflux pump MRP2: regulation of expression in physiopathological situations and by endogenous and exogenous compounds.
Cell biology and toxicology 2002;18(4):221-33.
2001: A Mannechez; B Collet; Léa Payen; Valérie Lecureur; Olivier Fardel; Laurence Le Moyec; Jacques D de Certaines; Geneviève Leray
Differentiation of the P-gp and MRP1 multidrug resistance systems by mobile lipid 1H-NMR spectroscopy and phosphatidylserine externalization.
Anticancer research 2001;21(6A):3915-9.
2001: Olivier Fardel; Léa Payen; Arnaud Courtois; Laurent Vernhet; Valérie Lecureur
Regulation of biliary drug efflux pump expression by hormones and xenobiotics.
Toxicology 2001;167(1):37-46.
2001: Béatrice Laupèze; Laurence Amiot; Nicolas Bertho; Jean-Marc Grosset; G Lehne; Renée Fauchet; Olivier Fardel
Differential expression of the efflux pumps P-glycoprotein and multidrug resistance-associated protein in human monocyte-derived dendritic cells.
Human immunology 2001;62(10):1073-80.
2001: Laurent Vernhet; M P Séité; Nathalie Allain; André Guillouzo; Olivier Fardel
Arsenic induces expression of the multidrug resistance-associated protein 2 (MRP2) gene in primary rat and human hepatocytes.
The Journal of pharmacology and experimental therapeutics 2001;298(1):234-9.
2001: Laurent Vernhet; Nathalie Allain; Léa Payen; Jean Pierre Anger; André Guillouzo; Olivier Fardel
Resistance of human multidrug resistance-associated protein 1-overexpressing lung tumor cells to the anticancer drug arsenic trioxide.
Biochemical pharmacology 2001;61(11):1387-91.
2001: Léa Payen; Arnaud Courtois; M Loewert; André Guillouzo; Olivier Fardel
Reactive oxygen species-related induction of multidrug resistance-associated protein 2 expression in primary hepatocytes exposed to sulforaphane.
Biochemical and biophysical research communications 2001;282(1):257-63.
2001: Béatrice Laupèze; Laurence Amiot; Léa Payen; Bernard Drénou; Jean-Marc Grosset; G Lehne; Renée Fauchet; Olivier Fardel
Multidrug resistance protein (MRP) activity in normal mature leukocytes and CD34-positive hematopoietic cells from peripheral blood.
Life sciences 2001;68(11):1323-31.
2001: Léa Payen; L Delugin; Arnaud Courtois; Yolande Trinquart; André Guillouzo; Olivier Fardel
The sulphonylurea glibenclamide inhibits multidrug resistance protein (MRP1) activity in human lung cancer cells.
British journal of pharmacology 2001;132(3):778-84.
2001: Léa Payen; Arnaud Courtois; Sophie Langouët; André Guillouzo; Olivier Fardel
Unaltered expression of multidrug resistance transporters in polycyclic aromatic hydrocarbon-resistant rat liver cells.
Toxicology 2001;156(2-3):109-17.
2000: Léa Payen; Arnaud Courtois; J P Campion; André Guillouzo; Olivier Fardel
Characterization and inhibition by a wide range of xenobiotics of organic anion excretion by primary human hepatocytes.
Biochemical pharmacology 2000;60(12):1967-75.
2000: Valérie Lecureur; Arnaud Courtois; Léa Payen; L Verhnet; André Guillouzo; Olivier Fardel
Expression and regulation of hepatic drug and bile acid transporters.
Toxicology 2000;153(1-3):203-19.
2000: Nicolas Bertho; Bernard Drénou; Béatrice Laupeze; C L Berre; Laurence Amiot; Jean-Marc Grosset; Olivier Fardel; Dominique Charron; Nuala Mooney; Renée Fauchet
HLA-DR-mediated apoptosis susceptibility discriminates differentiation stages of dendritic/monocytic APC.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(5):2379-85.
2000: Laurent Vernhet; Nathalie Allain; Caroline Bardiau; Jean Pierre Anger; Olivier Fardel
Differential sensitivities of MRP1-overexpressing lung tumor cells to cytotoxic metals.
Toxicology 2000;142(2):127-34.
1999: Arnaud Courtois; Léa Payen; Laurent Vernhet; Fabrice MOREL; André Guillouzo; Olivier Fardel
Differential regulation of canalicular multispecific organic anion transporter (cMOAT) expression by the chemopreventive agent oltipraz in primary rat hepatocytes and in rat liver.
Carcinogenesis 1999;20(12):2327-30.
1999: Arnaud Courtois; Léa Payen; André Guillouzo; Olivier Fardel
Up-regulation of multidrug resistance-associated protein 2 (MRP2) expression in rat hepatocytes by dexamethasone.
FEBS letters 1999;459(3):381-5.
1999: Béatrice Laupeze; Laurence Amiot; Arnaud Courtois; Laurent Vernhet; Bernard Drenou; Renée Fauchet; Olivier Fardel
Use of the anionic dye carboxy-2',7'-dichlorofluorescein for sensitive flow cytometric detection of multidrug resistance-associated protein activity.
International journal of oncology 1999;15(3):571-6.
1999: B Laupéze; Olivier Fardel; M Onno; Nicolas Bertho; Bernard Drénou; Renée Fauchet; Laurence Amiot
Differential expression of major histocompatibility complex class Ia, Ib, and II molecules on monocytes-derived dendritic and macrophagic cells.
Human immunology 1999;60(7):591-7.
1999: Léa Payen; L Delugin; Arnaud Courtois; Yolande Trinquart; André Guillouzo; Olivier Fardel
Reversal of MRP-mediated multidrug resistance in human lung cancer cells by the antiprogestatin drug RU486.
Biochemical and biophysical research communications 1999;258(3):513-8.
1999: Léa Payen; Arnaud Courtois; Laurent Vernhet; André Guillouzo; Olivier Fardel
The multidrug resistance-associated protein (MRP) is over-expressed and functional in rat hepatoma cells.
International journal of cancer. Journal international du cancer 1999;81(3):479-85.
1999: Arnaud Courtois; Léa Payen; Laurent Vernhet; E G de Vries; André Guillouzo; Olivier Fardel
Inhibition of multidrug resistance-associated protein (MRP) activity by rifampicin in human multidrug-resistant lung tumor cells.
Cancer letters 1999;139(1):97-104.
1999: Laurent Vernhet; Arnaud Courtois; Nathalie Allain; Léa Payen; Jean Pierre Anger; André Guillouzo; Olivier Fardel
Overexpression of the multidrug resistance-associated protein (MRP1) in human heavy metal-selected tumor cells.
FEBS letters 1999;443(3):321-5.
1999: Arnaud Courtois; Léa Payen; D Lagadic; André Guillouzo; Olivier Fardel
Evidence for a multidrug resistance-associated protein 1 (MRP1)-related transport system in cultured rat liver biliary epithelial cells.
Life sciences 1999;64(9):763-74.
1998: Anne Corlu; I Lamy; Gennady Ilyin; Olivier Fardel; B Kneip; C Le Jossic; Christiane Guguen-Guillouzo
Hematopoiesis-promoting activity of rat liver biliary epithelial cells: involvement of a cell surface molecule, liver-regulating protein.
Experimental hematology 1998;26(5):382-94.
1998: Valérie Lecureur; André Guillouzo; Olivier Fardel
Differential expression of the polyspecific drug transporter OCT1 in rat hepatocarcinoma cells.
Cancer letters 1998;126(2):227-33.
1998: Olivier Fardel; Léa Payen; Arnaud Courtois; Valérie Lecureur; André Guillouzo
Induction of multidrug resistance gene expression in rat liver cells in response to acute treatment by the DNA-damaging agent methyl methanesulfonate.
Biochemical and biophysical research communications 1998;245(1):85-9.
1998: Thierry Lamy; Bernard Drenou; Olivier Fardel; Laurence Amiot; Isabelle Grulois; PY Le Prise; Thomas P Loughran; Renée Fauchet
Multidrug resistance analysis in lymphoproliferative disease of large granular lymphocytes.
British journal of haematology 1998;100(3):509-15.
1998: Olivier Fardel; Léa Payen; Arnaud Courtois; Bernard Drenou; Renée Fauchet; B Rault
Differential expression and activity of P-glycoprotein and multidrug resistance-associated protein in CD34-positive KG1a leukemic cells.
International journal of oncology 1998;12(2):315-9.
1997: I Lamy; Anne Corlu; Olivier Fardel; V Gandemer; Mickael Rialland; C Leberre; PY Le Prise; Renée Fauchet; L Coulombel; Christiane Guguen-Guillouzo
Rat liver biliary epithelial cells support long-term production of haemopoietic progenitors from human CD34 cells.
British journal of haematology 1997;98(3):560-8.
1997: Olivier Fardel; Valérie Lecureur; S Daval; Anne Corlu; André Guillouzo
Up-regulation of P-glycoprotein expression in rat liver cells by acute doxorubicin treatment.
European journal of biochemistry / FEBS 1997;246(1):186-92.
1997: Bernard Drénou; Thierry Lamy; Laurence Amiot; Olivier Fardel; Sylvie Caulet-Maugendre; M Sasportes; J Diebold; Pierre-Yves Le Prisé; Renée Fauchet
CD3- CD56+ non-Hodgkin's lymphomas with an aggressive behavior related to multidrug resistance.
Blood 1997;89(8):2966-74.
1996: Olivier Fardel; Valérie Lecureur; André Guillouzo
The P-glycoprotein multidrug transporter.
General pharmacology 1996;27(8):1283-91.
1996: Olivier Fardel; Arnaud Courtois; Bernard Drenou; Thierry Lamy; Valérie Lecureur; Pierre-Yves Le Prisé; Renée Fauchet
Inhibition of P-glycoprotein activity in human leukemic cells by mifepristone.
Anti-cancer drugs 1996;7(6):671-7.
1996: Olivier Fardel; Valérie Lecureur; Anne Corlu; André Guillouzo
P-glycoprotein induction in rat liver epithelial cells in response to acute 3-methylcholanthrene treatment.
Biochemical pharmacology 1996;51(11):1427-36.
1996: Valérie Lecureur; André Guillouzo; Olivier Fardel
Differential regulation of mdr genes in response to 2-acetylaminofluorene treatment in cultured rat and human hepatocytes.
Carcinogenesis 1996;17(5):1157-60.
1995: Thierry Lamy; Bernard Drenou; Isabelle Grulois; Olivier Fardel; Christian Jacquelinet; Jean E Goasguen; Charly Dauriac; Laurence Amiot; M Bernard; Renée Fauchet
Multi-drug resistance (MDR) activity in acute leukemia determined by rhodamine 123 efflux assay.
Leukemia 1995;9(9):1549-55.
1995: Olivier Fardel; Valérie Lecureur; Pascal Loyer; André Guillouzo
Rifampicin enhances anti-cancer drug accumulation and activity in multidrug-resistant cells.
Biochemical pharmacology 1995;49(9):1255-60.
1995: Isabelle Grulois; Olivier Fardel; Bernard Drenou; Thierry Lamy; Pierre-Yves Le Prisé; Renée Fauchet
Multidrug resistance in B-cell chronic lymphocytic leukemia.
Acta haematologica 1995;94(2):78-83.
1994: Valérie Lecureur; Olivier Fardel; André Guillouzo
The antiprogestatin drug RU 486 potentiates doxorubicin cytotoxicity in multidrug resistant cells through inhibition of P-glycoprotein function.
FEBS letters 1994;355(2):187-91.
1994: Olivier Fardel; Pascal Loyer; Valérie Lecureur; Denise Glaise; André Guillouzo
Constitutive expression of functional P-glycoprotein in rat hepatoma cells.
European journal of biochemistry / FEBS 1994;219(1-2):521-8.
1993: Bernard Drenou; Olivier Fardel; Laurence Amiot; Renée Fauchet
Detection of P glycoprotein activity on normal and leukemic CD34+ cells.
Leukemia research 1993;17(12):1031-5.
1993: Olivier Fardel; Valérie Lecureur; André Guillouzo
Regulation by dexamethasone of P-glycoprotein expression in cultured rat hepatocytes.
FEBS letters 1993;327(2):189-93.
1992: Olivier Fardel; Pascal Loyer; F Morel; D Ratanasavanh; André Guillouzo
Modulation of multidrug resistance gene expression in rat hepatocytes maintained under various culture conditions.
Biochemical pharmacology 1992;44(11):2259-62.
1992: Olivier Fardel; D Ratanasavanh; Pascal Loyer; B Ketterer; André Guillouzo
Overexpression of the multidrug resistance gene product in adult rat hepatocytes during primary culture.
European journal of biochemistry / FEBS 1992;205(2):847-52.