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Robert Farese

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Natalie Krahmer; Matthias Mann; Gabriele Stoehr; Robert V Farese; Maximiliane Hilger; Nora Kory; Florian Wilfling; Tobias C Walther
Protein correlation profiles identify lipid droplet proteins with high confidence.
Gregory Camus; Robert V Farese; Joel T Haas; Eva Herker; Ankit A Modi; Holly R Ramage; Melanie Ott
Diacylglycerol acyltransferase-1 localizes hepatitis C virus NS5A protein to lipid droplets and enhances NS5A interaction with the viral capsid core.
Andrew D Nguyen; Thi A Nguyen; Tobias C Walther; Gang Yu; Basar Cenik; W Sean Davidson; Joachim Herz; Robert V Farese
Secreted progranulin is a homodimer and is not a component of high density lipoproteins (HDL).

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All Publications

2013: Natalie Krahmer; Matthias Mann; Gabriele Stoehr; Robert V Farese; Maximiliane Hilger; Nora Kory; Florian Wilfling; Tobias C Walther
Protein correlation profiles identify lipid droplet proteins with high confidence.
Molecular & cellular proteomics : MCP 2013;12(5):1115-26.
2013: Gregory Camus; Robert V Farese; Joel T Haas; Eva Herker; Ankit A Modi; Holly R Ramage; Melanie Ott
Diacylglycerol acyltransferase-1 localizes hepatitis C virus NS5A protein to lipid droplets and enhances NS5A interaction with the viral capsid core.
The Journal of biological chemistry 2013;288(14):9915-23.
2013: Andrew D Nguyen; Thi A Nguyen; Tobias C Walther; Gang Yu; Basar Cenik; W Sean Davidson; Joachim Herz; Robert V Farese
Secreted progranulin is a homodimer and is not a component of high density lipoproteins (HDL).
The Journal of biological chemistry 2013;288(12):8627-35.
2013: Anthony J Filiano; Fen-Biao Gao; Eric J Huang; Jian Jiao; Lauren Herl Martens; Brian A Warmus; Allen H Young; Zhijun Zhang; Ping Zhou; Grisell Diaz-Ramirez; Robert V Farese; Erik D Roberson
Dissociation of frontotemporal dementia-related deficits and neuroinflammation in progranulin haploinsufficient mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013;33(12):5352-61.
2013: Florian Wilfling; Huajin Wang; Joerg Bewersdorf; Kimberly K Buhman; Ji-Xin Cheng; Romain Christiano; Rosalind A Coleman; Robert V Farese; Florian Fröhlich; Travis J Gould; Morven Graham; Joel T Haas; Natalie Krahmer; Xinran Liu; Aki Uchida; Tobias C Walther
Triacylglycerol synthesis enzymes mediate lipid droplet growth by relocalizing from the ER to lipid droplets.
Developmental cell 2013;24(4):384-99.
2013: Tadahiro Shimazu; Kotaro Shirakawa; Robert D Stevens; Scott Ulrich; Katerina Akassoglou; Rafael de Cabo; Robert V Farese; Carrie A Grueter; Wenjuan He; Matthew David Hirschey; Natacha Le Moan; Hyungwook Lim; Christopher B Newgard; John Newman; Laura R Saunders; Eric Verdin
Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor.
Science (New York, N.Y.) 2013;339(6116):211-4.
2012: Joel T Haas; Chaim Jalas; Andrew Kirby; Elaine Lim; Mauro S Toporovski; Tobias C Walther; Harland S Winter; Brendan Blumenstiel; David Branski; Mark J Daly; Matthew DeFelice; Stacey Gabriel; Carrie A Grueter; Robert V Farese
DGAT1 mutation is linked to a congenital diarrheal disorder.
The Journal of clinical investigation 2012;122(12):4680-4.
2012: Maria Armakola; Sami J Barmada; Zamia Diaz; Xiaodong Fang; Robert V Farese; Matthew D Figley; Steven Finkbeiner; Matthew J Higgins; Nevan J Krogan; Emily A Scarborough; James Shorter; Aaron D Gitler
Inhibition of RNA lariat debranching enzyme suppresses TDP-43 toxicity in ALS disease models.
Nature genetics 2012;44(12):1302-9.
2012: Thomas O Eichmann; Robert V Farese; Joel T Haas; Manju Kumari; Achim Lass; Robert Zimmermann; Rudolf Zechner
Studies on the substrate and stereo/regioselectivity of adipose triglyceride lipase, hormone-sensitive lipase, and diacylglycerol-O-acyltransferases.
The Journal of biological chemistry 2012;287(49):41446-57.
2012: Lauren Herl Martens; Sang-Won Min; Binggui Sun; Jiasheng Zhang; Ping Zhou; Steven Finkbeiner; Li Gan; Eric J Huang; Sherry Kamiya; Sami J Barmada; Robert V Farese
Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury.
The Journal of clinical investigation 2012;122(11):3955-9.
2012: Sandra Almeida; Giovanni Coppola; Robert V Farese; Kensuke Futai; Fuying Gao; Daniel H Geschwind; Michael D Geschwind; Davide Gianni; Anna Karydas; Wenjie Mao; Bruce L Miller; Miguel Sena-Esteves; M Carmela Tartaglia; Zhijun Zhang; Fen-Biao Gao
Induced pluripotent stem cell models of progranulin-deficient frontotemporal dementia uncover specific reversible neuronal defects.
Cell reports 2012;2(4):789-98.
2012: Ningyi Xu; Shaobing O Zhang; Sean A McKinney; Sudheer Bobba; Ronald A Cole; Robert V Farese; Fengli Guo; Joel T Haas; Ho Yi Mak
The FATP1-DGAT2 complex facilitates lipid droplet expansion at the ER-lipid droplet interface.
The Journal of cell biology 2012;198(5):895-911.
2012: Joel T Haas; Mary E Haas; Matthew Hirschey; Irwin Kurland; Ji Miao; Bhavapriya Vaitheesvaran; Yanning Wang; Enpeng Zhao; Dipanjan Chanda; Rosanne Crooke; Robert V Farese; Fabienne Foufelle; Mark Graham; Sudha B Biddinger
Hepatic insulin signaling is required for obesity-dependent expression of SREBP-1c mRNA but not for feeding-dependent expression.
Cell metabolism 2012;15(6):873-84.
2012: Jun Zhang; Janet K Sawyer; Martha Wilson; J Mark Brown; Matthew A Davis; Robert V Farese; Kathryn L Kelley; Stephanie M Marshall; Lawrence L Rudel
Tissue-specific knockouts of ACAT2 reveal that intestinal depletion is sufficient to prevent diet-induced cholesterol accumulation in the liver and blood.
Journal of lipid research 2012;53(6):1144-52.
2012: Robert V Farese; Mini P Sajan
Atypical protein kinase C in cardiometabolic abnormalities.
Current opinion in lipidology 2012;23(3):175-81.
2012: Robert V Farese; Christopher B Newgard; Rudolf Zechner; Tobias C Walther
The problem of establishing relationships between hepatic steatosis and hepatic insulin resistance.
Cell metabolism 2012;15(5):570-3.
2012: Mini Sajan; Robert V Farese
Insulin signalling in hepatocytes of humans with type 2 diabetes: excessive production and activity of protein kinase C-ι (PKC-ι) and dependent processes and reversal by PKC-ι inhibitors.
Diabetologia 2012;55(5):1446-57.
2012: Mini Sajan; Mildred Acevedo-Duncan; Ursula Braun; Alan P Fields; C Ronald Kahn; Michael Leitges; Stephen Mastorides; Sonali Nimal; Robert V Farese
Correction of metabolic abnormalities in a rodent model of obesity, metabolic syndrome, and type 2 diabetes mellitus by inhibitors of hepatic protein kinase C-ι.
Metabolism: clinical and experimental 2012;61(4):459-69.
2012: Tobias C Walther; Robert V Farese
Lipid droplets and cellular lipid metabolism.
Annual review of biochemistry 2012;81():687-714.
2012: Ryan S Streeper; Eric Verdin; Ping Zhou; Sylvaine Cases; Carrie A Grueter; Matthew David Hirschey; Suneil K Koliwad; Malin C Levin; Nathan Salomonis; Robert V Farese
Deficiency of the lipid synthesis enzyme, DGAT1, extends longevity in mice.
Aging 2012;4(1):13-27.
2011: Charles Harris; Eva Herker; Robert V Farese; Melanie Ott
Hepatitis C virus core protein decreases lipid droplet turnover: a mechanism for core-induced steatosis.
The Journal of biological chemistry 2011;286(49):42615-25.
2011: Matthew David Hirschey; Enxuan Jing; C Ronald Kahn; Sanjay Kakar; Johanna Kuusisto; Markku Laakso; Maggie M Lam; Michael J Muehlbauer; Christopher B Newgard; Bjoern Schwer; Tadahiro Shimazu; Alena Stančáková; Robert D Stevens; Frederick W Alt; Bradley Aouizerat; Nathan M Bass; Amy M Collins; Robert V Farese; Eric Goetzman; Carrie A Grueter; Eric Verdin
SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome.
Molecular cell 2011;44(2):177-90.
2011: Natalie Krahmer; Susanne Lingrell; Matthias Mann; Heather W Newman; Marc Schmidt-Supprian; Dennis E Vance; Robert V Farese; Yi Guo; Klaus Heger; Maximiliane Hilger; Florian Wilfling; Tobias C Walther
Phosphatidylcholine synthesis for lipid droplet expansion is mediated by localized activation of CTP:phosphocholine cytidylyltransferase.
Cell metabolism 2011;14(4):504-15.
2011: Ezra Y Rosen; Revital Versano; Eric M Wexler; Kellen D Winden; Ping Zhou; Giovanni Coppola; Robert V Farese; Fuying Gao; Lauren Herl Martens; Michael C Oldham; Daniel Geschwind
Functional genomic analyses identify pathways dysregulated by progranulin deficiency, implicating Wnt signaling.
Neuron 2011;71(6):1030-42.
2011: Mara Monetti; Christopher Newgard; Matthew J Watt; Robert V Farese; Andrea L Hevener; Brian K Hubbard; Malin C Levin; Robert V Farese
Hepatic acyl-CoA:diacylglcyerol acyltransferase (DGAT) overexpression, diacylglycerol, and insulin sensitivity.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(34):E523; author reply E524.
2011: Naveen Sharma; Edward B Arias; Abhijit D Bhat; Donel A Sequea; Steve Ho; Kelsey K Croff; Mini P Sajan; Robert V Farese; Gregory D Cartee
Mechanisms for increased insulin-stimulated Akt phosphorylation and glucose uptake in fast- and slow-twitch skeletal muscles of calorie-restricted rats.
American journal of physiology. Endocrinology and metabolism 2011;300(6):E966-78.
2011: Basar Cenik; Chantelle F Sephton; Colleen M Dewey; Xunde Xian; Shuguang Wei; Kimberley Yu; Wenze Niu; Giovanni Coppola; Sarah E Coughlin; Suzee E Lee; Daniel R Dries; Sandra Almeida; Daniel Geschwind; Fen-Biao Gao; Bruce L Miller; Robert V Farese; Bruce A Posner; Gang Yu; Joachim Herz
Suberoylanilide hydroxamic acid (vorinostat) up-regulates progranulin transcription: rational therapeutic approach to frontotemporal dementia.
The Journal of biological chemistry 2011;286(18):16101-8.
2011: Charles A Harris; Joel T Haas; Ryan S Streeper; Scot J Stone; Manju Kumari; Kui Yang; Xianlin Han; Nicholas Brownell; Richard W Gross; Rudolf Zechner; Robert V Farese
DGAT enzymes are required for triacylglycerol synthesis and lipid droplets in adipocytes.
Journal of lipid research 2011;52(4):657-67.
2011: Aimee W Kao; Robin J Eisenhut; Lauren Herl Martens; Ayumi Nakamura; Anne Huang; Josh A Bagley; Ping Zhou; Alberto de Luis; Lukas J Neukomm; Juan Cabello; Robert V Farese; Cynthia Kenyon
A neurodegenerative disease mutation that accelerates the clearance of apoptotic cells.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(11):4441-6.
2011: Joerg Bewersdorf; Robert V Farese; Tobias C Walther
A new way to look at fat.
Nature methods 2011;8(2):132-3.
2011: Heidi K Ortmeyer; Mini P Sajan; Atsushi Miura; Yoshinore Kanoh; Jose Rivas; Yongxiang Li; Mary L Standaert; Alice S Ryan; Noni L Bodkin; Robert V Farese; Barbara C Hansen
Insulin signaling and insulin sensitizing in muscle and liver of obese monkeys: peroxisome proliferator-activated receptor gamma agonist improves defective activation of atypical protein kinase C.
Antioxidants & redox signaling 2011;14(2):207-19.
2010: Eva Herker; Charles Harris; Céline Hernandez; Arnaud Carpentier; Katrin Kaehlcke; Arielle R Rosenberg; Robert V Farese; Melanie Ott
Efficient hepatitis C virus particle formation requires diacylglycerol acyltransferase-1.
Nature medicine 2010;16(11):1295-8.
2010: Naveen Sharma; Edward B Arias; Mini P Sajan; James G MacKrell; Abhijit D Bhat; Robert V Farese; Gregory D Cartee
Insulin resistance for glucose uptake and Akt2 phosphorylation in the soleus, but not epitrochlearis, muscles of old vs. adult rats.
Journal of applied physiology (Bethesda, Md. : 1985) 2010;108(6):1631-40.
2010: Matthew David Hirschey; Tadahiro Shimazu; Eric Goetzman; Enxuan Jing; Bjoern Schwer; David Lombard; Carrie A Grueter; Charles Harris; Sudha Biddinger; Olga R Ilkayeva; Robert D Stevens; Yu Li; Asish K Saha; Neil B Ruderman; James R Bain; Christopher B Newgard; Robert V Farese; Frederick W Alt; C Ronald Kahn; Eric Verdin
SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation.
Nature 2010;464(7285):121-5.
2010: Victoria Rotter Sopasakis; Pixu Liu; Ryo Suzuki; Tatsuya Kondo; Jonathon Winnay; Thien T Tran; Tomoichiro Asano; Graham Smyth; Mini P Sajan; Robert V Farese; C Ronald Kahn; Jean J Zhao
Specific roles of the p110alpha isoform of phosphatidylinsositol 3-kinase in hepatic insulin signaling and metabolic regulation.
Cell metabolism 2010;11(3):220-30.
2010: Suneil K Koliwad; Ryan S Streeper; Mara Monetti; Ivo Cornelissen; Liana Chan; Koji Terayama; Stephen Naylor; Meghana Rao; Brian Hubbard; Robert V Farese
DGAT1-dependent triacylglycerol storage by macrophages protects mice from diet-induced insulin resistance and inflammation.
The Journal of clinical investigation 2010;120(3):756-67.
2010: Robert V Farese; Mini P Sajan
Metabolic functions of atypical protein kinase C: "good" and "bad" as defined by nutritional status.
American journal of physiology. Endocrinology and metabolism 2010;298(3):E385-94.
2010: Mini Sajan; G Bandyopadhyay; Atsushi Miura; Mary L Standaert; S Nimal; S L Longnus; Emmanuel Van Obberghen; I Hainault; F Foufelle; R Kahn; U Braun; Michael Leitges; Robert V Farese
AICAR and metformin, but not exercise, increase muscle glucose transport through AMPK-, ERK-, and PDK1-dependent activation of atypical PKC.
American journal of physiology. Endocrinology and metabolism 2010;298(2):E179-92.
2010: Jian Jiao; Lauren D Herl; Robert V Farese; Fen-Biao Gao
MicroRNA-29b regulates the expression level of human progranulin, a secreted glycoprotein implicated in frontotemporal dementia.
PloS one 2010;5(5):e10551.
2009: Joshua P Thaler; Sun Ju Choi; Mini P Sajan; Kayoko Ogimoto; Hong T Nguyen; Miles Matsen; Stephen C Benoit; Brent E Wisse; Robert V Farese; Michael W Schwartz
Atypical protein kinase C activity in the hypothalamus is required for lipopolysaccharide-mediated sickness responses.
Endocrinology 2009;150(12):5362-72.
2009: Natalie Krahmer; Yi Guo; Robert V Farese; Tobias C Walther
SnapShot: Lipid Droplets.
Cell 2009;139(5):1024-1024.e1.
2009: Robert V Farese; Tobias C Walther
Lipid droplets finally get a little R-E-S-P-E-C-T.
Cell 2009;139(5):855-60.
2009: Suneil K Koliwad; Taiyi Kuo; Lauren E Shipp; Nora E Gray; Fredrik Backhed; Alex Yick-Lun So; Robert V Farese; Jen-Chywan Wang
Angiopoietin-like 4 (ANGPTL4, fasting-induced adipose factor) is a direct glucocorticoid receptor target and participates in glucocorticoid-regulated triglyceride metabolism.
The Journal of biological chemistry 2009;284(38):25593-601.
2009: Shaodong Guo; Kyle D Copps; Xiaocheng Dong; Sunmin Park; Zhiyong Cheng; Alessandro Pocai; Luciano Rossetti; Mini Sajan; Robert V Farese; Morris F White
The Irs1 branch of the insulin signaling cascade plays a dominant role in hepatic nutrient homeostasis.
Molecular and cellular biology 2009;29(18):5070-83.
2009: Claudio J Villanueva; Mara Monetti; Michelle Shih; Ping Zhou; Steve M Watkins; Sanjay Bhanot; Robert V Farese
Specific role for acyl CoA:Diacylglycerol acyltransferase 1 (Dgat1) in hepatic steatosis due to exogenous fatty acids.
Hepatology (Baltimore, Md.) 2009;50(2):434-42.
2009: Mini P Sajan; Mary L Standaert; Sonali Nimal; Usha Varanasi; Tina Pastoor; Stephen Mastorides; Ursula Braun; Michael Leitges; Robert V Farese
The critical role of atypical protein kinase C in activating hepatic SREBP-1c and NFkappaB in obesity.
Journal of lipid research 2009;50(6):1133-45.
2009: Tobias C Walther; Robert V Farese
The life of lipid droplets.
Biochimica et biophysica acta 2009;1791(6):459-66.
2009: Chi-Liang Eric Yen; Mei-Leng Cheong; Carrie Grueter; Ping Zhou; Junya Moriwaki; Jinny S Wong; Brian Hubbard; Stephen Marmor; Robert V Farese
Deficiency of the intestinal enzyme acyl CoA:monoacylglycerol acyltransferase-2 protects mice from metabolic disorders induced by high-fat feeding.
Nature medicine 2009;15(4):442-6.
2009: Yi Guo; Kimberly R Cordes; Robert V Farese; Tobias C Walther
Lipid droplets at a glance.
Journal of cell science 2009;122(Pt 6):749-52.
2009: Scot J Stone; Malin C Levin; Ping Zhou; Jiayi Han; Tobias C Walther; Robert V Farese
The endoplasmic reticulum enzyme DGAT2 is found in mitochondria-associated membranes and has a mitochondrial targeting signal that promotes its association with mitochondria.
The Journal of biological chemistry 2009;284(8):5352-61.
2009: Michelle Y S Shih; Maureen Kane; Ping Zhou; Chi-Liang Eric Yen; Ryan S Streeper; Joseph L Napoli; Robert V Farese
Retinol Esterification by DGAT1 Is Essential for Retinoid Homeostasis in Murine Skin.
The Journal of biological chemistry 2009;284(7):4292-9.
2008: Chi-Liang Eric Yen; Scot J Stone; Suneil Koliwad; Charles Harris; Robert V Farese
Thematic review series: glycerolipids. DGAT enzymes and triacylglycerol biosynthesis.
Journal of lipid research 2008;49(11):2283-301.
2008: Kaori Minehira; Stephen G Young; Claudio J Villanueva; Laxman Yetukuri; Matej Oresic; Marc K Hellerstein; Robert V Farese; Jay D Horton; Frederic Preitner; Bernard Thorens; Luc Tappy
Blocking VLDL secretion causes hepatic steatosis but does not affect peripheral lipid stores or insulin sensitivity in mice.
Journal of lipid research 2008;49(9):2038-44.
2008: Yi Guo; Tobias C Walther; Meghana Rao; Nico Stuurman; Gohta Goshima; Koji Terayama; Jinny S Wong; Ronald D Vale; Peter Walter; Robert V Farese
Functional genomic screen reveals genes involved in lipid-droplet formation and utilization.
Nature 2008;453(7195):657-61.
2007: Malin C Levin; Mara Monetti; Matthew J Watt; Mini P Sajan; Robert D Stevens; James R Bain; Christopher B Newgard; Robert V Farese; Robert V Farese
Increased lipid accumulation and insulin resistance in transgenic mice expressing DGAT2 in glycolytic (type II) muscle.
American journal of physiology. Endocrinology and metabolism 2007;293(6):E1772-81.
2007: David Lombard; Frederick W Alt; Hwei-Ling Cheng; Jakob Bunkenborg; Ryan S Streeper; Raul Mostoslavsky; Jennifer Kim; George D Yancopoulos; David M Valenzuela; Andrew Murphy; Yinhua Yang; Yaohui Chen; Matthew David Hirschey; Roderick T Bronson; Marcia Haigis; Leonard Guarente; Robert V Farese; Sherman Weissman; Eric Verdin; Bjoern Schwer
Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation.
Molecular and cellular biology 2007;27(24):8807-14.
2007: Liana C Chan; Wendy Peters; Yan Xu; Jerold Chun; Robert V Farese; Sylvaine Cases
LPA3 receptor mediates chemotaxis of immature murine dendritic cells to unsaturated lysophosphatidic acid (LPA).
Journal of leukocyte biology 2007;82(5):1193-200.
2007: Mara Monetti; Malin C Levin; Matthew J Watt; Mini P Sajan; Stephen Marmor; Brian K Hubbard; Robert D Stevens; James R Bain; Christopher B Newgard; Robert V Farese; Andrea L Hevener; Robert V Farese
Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver.
Cell metabolism 2007;6(1):69-78.
2006: Scot J Stone; Malin C Levin; Robert V Farese
Membrane topology and identification of key functional amino acid residues of murine acyl-CoA:diacylglycerol acyltransferase-2.
The Journal of biological chemistry 2006;281(52):40273-82.
2006: Brian J Feldman; Ryan S Streeper; Robert V Farese; Keith R Yamamoto
Myostatin modulates adipogenesis to generate adipocytes with favorable metabolic effects.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(42):15675-80.
2006: John S Millar; Scot J Stone; Uwe J F Tietge; Bryan Tow; Jeffrey T Billheimer; Jinny S Wong; Robert L Hamilton; Robert V Farese; Daniel J Rader
Short-term overexpression of DGAT1 or DGAT2 increases hepatic triglyceride but not VLDL triglyceride or apoB production.
Journal of lipid research 2006;47(10):2297-305.
2006: Ryan S Streeper; Suneil K Koliwad; Claudio J Villanueva; Robert V Farese
Effects of DGAT1 deficiency on energy and glucose metabolism are independent of adiponectin.
American journal of physiology. Endocrinology and metabolism 2006;291(2):E388-94.
2006: Chi-Liang Eric Yen; Robert V Farese
Fat breakdown: a function for CGI-58 (ABHD5) provides a new piece of the puzzle.
Cell metabolism 2006;3(5):305-7.
2005: Chi-Liang Eric Yen; Charles H Brown; Mara Monetti; Robert V Farese
A human skin multifunctional O-acyltransferase that catalyzes the synthesis of acylglycerols, waxes, and retinyl esters.
Journal of lipid research 2005;46(11):2388-97.
2005: Chi-Liang Eric Yen; Mara Monetti; Betty J Burri; Robert V Farese
The triacylglycerol synthesis enzyme DGAT1 also catalyzes the synthesis of diacylglycerols, waxes, and retinyl esters.
Journal of lipid research 2005;46(7):1502-11.
2004: Joyce J Repa; Kimberly Buhman; Robert V Farese; John M Dietschy; Stephen D Turley
ACAT2 deficiency limits cholesterol absorption in the cholesterol-fed mouse: impact on hepatic cholesterol homeostasis.
Hepatology (Baltimore, Md.) 2004;40(5):1088-97.
2004: Sylvaine Cases; Ping Zhou; Jonathan Shillingford; Bryony S Wiseman; Jo Dee Fish; Christina S Angle; Lothar Hennighausen; Zena Werb; Robert V Farese
Development of the mammary gland requires DGAT1 expression in stromal and epithelial tissues.
Development (Cambridge, England) 2004;131(13):3047-55.
2004: Scot J Stone; Heather M Myers; Steven M Watkins; Barbara E Brown; Kenneth R Feingold; Peter M Elias; Robert V Farese
Lipopenia and skin barrier abnormalities in DGAT2-deficient mice.
The Journal of biological chemistry 2004;279(12):11767-76.
2004: Mary Beeson; Mini P Sajan; Joaquin Gomez Daspet; Victor Luna; Michelle Dizon; Dmitry Grebenev; Jennifer L Powe; Scott Lucidi; Atsushi Miura; Yoshinori Kanoh; Gautam Bandyopadhyay; Mary L Standaert; Timothy R Yeko; Robert V Farese
Defective Activation of Protein Kinase C-z in Muscle by Insulin and Phosphatidylinositol-3,4,5,-(PO(4))(3) in Obesity and Polycystic Ovary Syndrome.
Metabolic syndrome and related disorders 2004;2(1):49-56.
2003: Hubert C Chen; Dalan R Jensen; Heather M Myers; Robert H Eckel; Robert V Farese
Obesity resistance and enhanced glucose metabolism in mice transplanted with white adipose tissue lacking acyl CoA:diacylglycerol acyltransferase 1.
The Journal of clinical investigation 2003;111(11):1715-22.
2003: Chi-Liang Eric Yen; Robert V Farese
MGAT2, a monoacylglycerol acyltransferase expressed in the small intestine.
The Journal of biological chemistry 2003;278(20):18532-7.
2003: Emily L Willner; Bryan Tow; Kimberly Buhman; Martha Wilson; David A Sanan; Lawrence L Rudel; Robert V Farese
Deficiency of acyl CoA:cholesterol acyltransferase 2 prevents atherosclerosis in apolipoprotein E-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(3):1262-7.
2003: Hubert C Chen; Zuleika Ladha; Steven J Smith; Robert V Farese
Analysis of energy expenditure at different ambient temperatures in mice lacking DGAT1.
American journal of physiology. Endocrinology and metabolism 2003;284(1):E213-8.
2002: Hubert C Chen; Scot J Stone; Ping Zhou; Kimberly Buhman; Robert V Farese
Dissociation of obesity and impaired glucose disposal in mice overexpressing acyl coenzyme a:diacylglycerol acyltransferase 1 in white adipose tissue.
Diabetes 2002;51(11):3189-95.
2002: Hubert C Chen; Zuleika Ladha; Robert V Farese
Deficiency of acyl coenzyme a:diacylglycerol acyltransferase 1 increases leptin sensitivity in murine obesity models.
Endocrinology 2002;143(8):2893-8.
2002: Kimberly Buhman; Steven J Smith; Scot J Stone; Joyce J Repa; Jinny S Wong; Furn F Knapp; Betty J Burri; Robert L Hamilton; Nada A Abumrad; Robert V Farese
DGAT1 is not essential for intestinal triacylglycerol absorption or chylomicron synthesis.
The Journal of biological chemistry 2002;277(28):25474-9.
2002: Erwin H Ludwig; Robert W Mahley; E Palaoglu; Sinan Ozbayrakçi; Maureen E Balestra; I B Borecki; Thomas L Innerarity; Robert V Farese
DGAT1 promoter polymorphism associated with alterations in body mass index, high density lipoprotein levels and blood pressure in Turkish women.
Clinical genetics 2002;62(1):68-73.
2002: Hubert C Chen; Robert V Farese
Fatty acids, triglycerides, and glucose metabolism: recent insights from knockout mice.
Current opinion in clinical nutrition and metabolic care 2002;5(4):359-63.
2002: Robert V Farese
Function and dysfunction of aPKC isoforms for glucose transport in insulin-sensitive and insulin-resistant states.
American journal of physiology. Endocrinology and metabolism 2002;283(1):E1-11.
2002: Chi-Liang Eric Yen; Scot J Stone; Sylvaine Cases; Ping Zhou; Robert V Farese
Identification of a gene encoding MGAT1, a monoacylglycerol acyltransferase.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(13):8512-7.
2002: Hubert C Chen; Robert V Farese
Determination of adipocyte size by computer image analysis.
Journal of lipid research 2002;43(6):986-9.
2002: Hubert C Chen; Steven J Smith; Zuleika Ladha; Dalan R Jensen; Luis D Ferreira; Leslie K Pulawa; James G McGuire; Robert E Pitas; Robert H Eckel; Robert V Farese
Increased insulin and leptin sensitivity in mice lacking acyl CoA:diacylglycerol acyltransferase 1.
The Journal of clinical investigation 2002;109(8):1049-55.
2002: Scott W Leonard; Yuko Terasawa; Robert V Farese; Maret G Traber
Incorporation of deuterated RRR- or all-rac-alpha-tocopherol in plasma and tissues of alpha-tocopherol transfer protein--null mice.
The American journal of clinical nutrition 2002;75(3):555-60.
2002: Hubert C Chen; Steven J Smith; Bryan Tow; Peter M Elias; Robert V Farese
Leptin modulates the effects of acyl CoA:diacylglycerol acyltransferase deficiency on murine fur and sebaceous glands.
The Journal of clinical investigation 2002;109(2):175-81.
2001: Kimberly Buhman; Hubert C Chen; Robert V Farese
The enzymes of neutral lipid synthesis.
The Journal of biological chemistry 2001;276(44):40369-72.
2001: Sylvaine Cases; Scot J Stone; Ping Zhou; E Yen; Bryan Tow; K D Lardizabal; T Voelker; Robert V Farese
Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members.
The Journal of biological chemistry 2001;276(42):38870-6.
2001: Robert L Raffai; LM Dong; Robert V Farese; Karl H Weisgraber
Introduction of human apolipoprotein E4 "domain interaction" into mouse apolipoprotein E.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(20):11587-91.
2001: sabrina sonda; Li-Min Ting; S Novak; Kami Kim; Jacquelyn J Maher; Robert V Farese; Joel D Ernst
Cholesterol esterification by host and parasite is essential for optimal proliferation of Toxoplasma gondii.
The Journal of biological chemistry 2001;276(37):34434-40.
2001: Sergio Fazio; Amy S Major; Larry L Swift; Linda A Gleaves; M Accad; MacRae F Linton; Robert V Farese
Increased atherosclerosis in LDL receptor-null mice lacking ACAT1 in macrophages.
The Journal of clinical investigation 2001;107(2):163-71.
2000: Kimberly Buhman; M Accad; Robert V Farese
Mammalian acyl-CoA:cholesterol acyltransferases.
Biochimica et biophysica acta 2000;1529(1-3):142-54.
2000: Yuko Terasawa; Zuleika Ladha; Scott W Leonard; J D Morrow; DL Newland; David A Sanan; L Packer; Maret G Traber; Robert V Farese
Increased atherosclerosis in hyperlipidemic mice deficient in alpha -tocopherol transfer protein and vitamin E.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(25):13830-4.
2000: Kimberly Buhman; M Accad; S Novak; R S Choi; Jinny S Wong; Robert L Hamilton; Stephen D Turley; Robert V Farese
Resistance to diet-induced hypercholesterolemia and gallstone formation in ACAT2-deficient mice.
Nature medicine 2000;6(12):1341-7.
2000: Hubert C Chen; Robert V Farese
DGAT and triglyceride synthesis: a new target for obesity treatment?
Trends in cardiovascular medicine 2000;10(5):188-92.
2000: Steven J Smith; Sylvaine Cases; Dalan R Jensen; Hubert C Chen; E Sande; Bryan Tow; David A Sanan; Jacob Raber; Robert H Eckel; Robert V Farese
Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat.
Nature genetics 2000;25(1):87-90.
2000: M Accad; Steven J Smith; DL Newland; David A Sanan; L E King; MacRae F Linton; Sergio Fazio; Robert V Farese
Massive xanthomatosis and altered composition of atherosclerotic lesions in hyperlipidemic mice lacking acyl CoA:cholesterol acyltransferase 1.
The Journal of clinical investigation 2000;105(6):711-9.
2000: Xiaozhu Huang; M Griffiths; Joanne Wu; Robert V Farese; Dean Sheppard
Normal development, wound healing, and adenovirus susceptibility in beta5-deficient mice.
Molecular and cellular biology 2000;20(3):755-9.
1999: Yuko Terasawa; Sylvaine Cases; Jinny S Wong; Haris Jamil; S Jothi; Maret G Traber; L Packer; David A Gordon; Robert L Hamilton; Robert V Farese
Apolipoprotein B-related gene expression and ultrastructural characteristics of lipoprotein secretion in mouse yolk sac during embryonic development.
Journal of lipid research 1999;40(11):1967-77.
1999: H C Chen; Robert V Farese
Steroid hormones: Interactions with membrane-bound receptors.
Current biology : CB 1999;9(13):R478-81.
1998: Sylvaine Cases; Steven J Smith; Yao-Wu Zheng; Heather M Myers; Steven R Lear; E Sande; S Novak; Colin Collins; C B Welch; AJ Lusis; Sandra K Erickson; Robert V Farese
Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(22):13018-23.
1998: Sylvaine Cases; S Novak; Yao-Wu Zheng; Heather M Myers; Steven R Lear; E Sande; C B Welch; AJ Lusis; Thomas A Spencer; B R Krause; Sandra K Erickson; Robert V Farese
ACAT-2, a second mammalian acyl-CoA:cholesterol acyltransferase. Its cloning, expression, and characterization.
The Journal of biological chemistry 1998;273(41):26755-64.
1998: M Accad; Robert V Farese
Cholesterol homeostasis: a role for oxysterols.
Current biology : CB 1998;8(17):R601-4.
1998: Mark L Kahn; Yao-Wu Zheng; W Huang; V Bigornia; D Zeng; S Moff; Robert V Farese; Carmen Tam-Amersdorfer; Shaun R Coughlin
A dual thrombin receptor system for platelet activation.
Nature 1998;394(6694):690-4.
1998: Robert V Farese
Acyl CoA:cholesterol acyltransferase genes and knockout mice.
Current opinion in lipidology 1998;9(2):119-23.
1998: Robert V Farese; Joachim Herz
Cholesterol metabolism and embryogenesis.
Trends in genetics : TIG 1998;14(3):115-20.
1998: V L Meiner; C L Welch; Sylvaine Cases; Heather M Myers; E Sande; AJ Lusis; Robert V Farese
Adrenocortical lipid depletion gene (ald) in AKR mice is associated with an acyl-CoA:cholesterol acyltransferase (ACAT) mutation.
The Journal of biological chemistry 1998;273(2):1064-9.
1997: Landin Boring; J Gosling; Stephen W Chensue; Steven Kunkel; Robert V Farese; Hal E Broxmeyer; Israel F Charo
Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice.
The Journal of clinical investigation 1997;100(10):2552-61.
1997: V Meiner; Carmen Tam-Amersdorfer; MD Gunn; LM Dong; Karl H Weisgraber; S Novak; Heather M Myers; Sandra K Erickson; Robert V Farese
Tissue expression studies on the mouse acyl-CoA: cholesterol acyltransferase gene (Acact): findings supporting the existence of multiple cholesterol esterification enzymes in mice.
Journal of lipid research 1997;38(9):1928-33.
1996: V L Meiner; Sylvaine Cases; Heather M Myers; E Sande; Stefano Bellosta; M Schambelan; Robert E Pitas; J McGuire; Joachim Herz; Robert V Farese
Disruption of the acyl-CoA:cholesterol acyltransferase gene in mice: evidence suggesting multiple cholesterol esterification enzymes in mammals.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(24):14041-6.
1996: Robert V Farese; Murielle Véniant; CM Cham; L M Flynn; V Pierotti; Jeanne F Loring; M Traber; S Ruland; R S Stokowski; D Huszar; Stephen G Young
Phenotypic analysis of mice expressing exclusively apolipoprotein B48 or apolipoprotein B100.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(13):6393-8.
1996: A J Connolly; H Ishihara; Mark L Kahn; Robert V Farese; Shaun R Coughlin
Role of the thrombin receptor in development and evidence for a second receptor.
Nature 1996;381(6582):516-9.
1996: Robert V Farese; Sylvaine Cases; S L Ruland; H J Kayden; Jinny S Wong; Stephen G Young; Robert L Hamilton
A novel function for apolipoprotein B: lipoprotein synthesis in the yolk sac is critical for maternal-fetal lipid transport in mice.
Journal of lipid research 1996;37(2):347-60.
1996: Stephen G Young; Elaine Krul; S McCormick; Robert V Farese; MacRae F Linton
Identification and characterization of truncated forms of apolipoprotein B in hypobetalipoproteinemia.
Methods in enzymology 1996;263():120-45.
1995: Stephen G Young; CM Cham; Robert E Pitas; B J Burri; A Connolly; L Flynn; Anuradha S Pappu; Jinny S Wong; Robert L Hamilton; Robert V Farese
A genetic model for absent chylomicron formation: mice producing apolipoprotein B in the liver, but not in the intestine.
The Journal of clinical investigation 1995;96(6):2932-46.
1995: D A Purcell-Huynh; Robert V Farese; D F Johnson; L M Flynn; V Pierotti; D L Newland; MacRae F Linton; David A Sanan; Stephen G Young
Transgenic mice expressing high levels of human apolipoprotein B develop severe atherosclerotic lesions in response to a high-fat diet.
The Journal of clinical investigation 1995;95(5):2246-57.
1995: Robert V Farese; S L Ruland; L M Flynn; R P Stokowski; Stephen G Young
Knockout of the mouse apolipoprotein B gene results in embryonic lethality in homozygotes and protection against diet-induced hypercholesterolemia in heterozygotes.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(5):1774-8.
1994: B R Zysow; Clive R Pullinger; L K Hennessy; Robert V Farese; M Ghassemzadeh; John P Kane
The apolipoprotein C-II variant apoC-IILys19-->Thr is not associated with dyslipidemia in an affected kindred.
Clinical genetics 1994;45(6):292-7.
1994: Stephen G Young; Robert V Farese; V R Pierotti; S Taylor; D S Grass; MacRae F Linton
Transgenic mice expressing human apoB100 and apoB48.
Current opinion in lipidology 1994;5(2):94-101.
1993: MacRae F Linton; Robert V Farese; G Chiesa; D S Grass; P Chin; R E Hammer; H H Hobbs; Stephen G Young
Transgenic mice expressing high plasma concentrations of human apolipoprotein B100 and lipoprotein(a).
The Journal of clinical investigation 1993;92(6):3029-37.
1993: MacRae F Linton; Robert V Farese; Stephen G Young
Familial hypobetalipoproteinemia.
Journal of lipid research 1993;34(4):521-41.
1993: Stephen G Young; Clive R Pullinger; B R Zysow; H Hofmann-Radvani; M F Linton; Robert V Farese; J F Terdiman; S M Snyder; S M Grundy; G L Vega
Four new mutations in the apolipoprotein B gene causing hypobetalipoproteinemia, including two different frameshift mutations that yield truncated apolipoprotein B proteins of identical length.
Journal of lipid research 1993;34(3):501-7.
1992: Robert V Farese; L M Flynn; Stephen G Young
Modification of the apolipoprotein B gene in HepG2 cells by gene targeting.
The Journal of clinical investigation 1992;90(1):256-61.
1992: Robert V Farese; MacRae F Linton; Stephen G Young
Apolipoprotein B gene mutations affecting cholesterol levels.
Journal of internal medicine 1992;231(6):643-52.
1992: Robert V Farese; A Garg; V R Pierotti; Gloria Lena Vega; Stephen G Young
A truncated species of apolipoprotein B, B-83, associated with hypobetalipoproteinemia.
Journal of lipid research 1992;33(4):569-77.