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Richard Farndale

Research Profile

Chemicals & Drugs

Anatomy

Blood Platelets

Phenomena

Genes & Molecular Sequences

Amino Acid Sequences

Physiology

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Nathalie Cloutier; Catriona Cramb; Richard W Farndale; Reuben Gobezie; Lauren Lahey; David M Lee; Peter A Nigrovic; William H Robinson; Ruslan Shnayder; Roopashree Subbaiah; Sisareuth Tan; Alexandra Albert; Luc H Boudreau; Alain Brisson; Eric Boilard
The exposure of autoantigens by microparticles underlies the formation of potent inflammatory components: the microparticle-associated immune complexes.
Simon J Attwood; Dominique Bihan; Richard W Farndale; Samir W Hamaia; Debdulal Roy; Anna M C Simpson; Mark E Welland
Measurement of the Interaction Between Recombinant I-domain from Integrin alpha 2 beta 1 and a Triple Helical Collagen Peptide with the GFOGER Binding Motif Using Molecular Force Spectroscopy.
Tora Almquist; Richard W Farndale; Stefan H Jacobson; Per-Eric Lins; Paul Hjemdahl
Effects of lipid-lowering treatment on platelet reactivity and platelet-leukocyte aggregation in diabetic patients without and with chronic kidney disease: a randomized trial.

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2013: Nathalie Cloutier; Catriona Cramb; Richard W Farndale; Reuben Gobezie; Lauren Lahey; David M Lee; Peter A Nigrovic; William H Robinson; Ruslan Shnayder; Roopashree Subbaiah; Sisareuth Tan; Alexandra Albert; Luc H Boudreau; Alain Brisson; Eric Boilard
The exposure of autoantigens by microparticles underlies the formation of potent inflammatory components: the microparticle-associated immune complexes.
EMBO molecular medicine 2013;5(2):235-49.
2013: Simon J Attwood; Dominique Bihan; Richard W Farndale; Samir W Hamaia; Debdulal Roy; Anna M C Simpson; Mark E Welland
Measurement of the Interaction Between Recombinant I-domain from Integrin alpha 2 beta 1 and a Triple Helical Collagen Peptide with the GFOGER Binding Motif Using Molecular Force Spectroscopy.
International journal of molecular sciences 2013;14(2):2832-45.
2012: Tora Almquist; Richard W Farndale; Stefan H Jacobson; Per-Eric Lins; Paul Hjemdahl
Effects of lipid-lowering treatment on platelet reactivity and platelet-leukocyte aggregation in diabetic patients without and with chronic kidney disease: a randomized trial.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2012;27(9):3540-6.
2012: Chloe N Grover; Richard W Farndale; Serena M Best; Ruth E Cameron
The interplay between physical and chemical properties of protein films affects their bioactivity.
Journal of biomedical materials research. Part A 2012;100(9):2401-11.
2012: Stephanie M Jung; Yoshiki Miura; Masaaki Moroi; Tomohiro Nakagaki; Nicholas Pugh; Kenji Soejima; Steve P Watson; Michael C Berndt; Dominique Bihan; Elizabeth E Gardiner; Joanna-Marie Howes; Richard W Farndale
Constitutive dimerization of glycoprotein VI (GPVI) in resting platelets is essential for binding to collagen and activation in flowing blood.
The Journal of biological chemistry 2012;287(35):30000-13.
2012: Nathalie Cloutier; Richard W Farndale; Steve Lacroix; Peter A Nigrovic; Alexandre Paré; H Ralph Schumacher; Eric Boilard
Platelets can enhance vascular permeability.
Blood 2012;120(6):1334-43.
2012: Chloe N Grover; Jessica H Gwynne; Samir W Hamaia; Nicholas Pugh; Serena M Best; Richard W Farndale; Ruth E Cameron
Crosslinking and composition influence the surface properties, mechanical stiffness and cell reactivity of collagen-based films.
Acta biomaterialia 2012;8(8):3080-90.
2012: Szymon W Manka; Gillian Murphy; Nicolas Raynal; Robert Visse; Dominique Bihan; Federico Carafoli; Jan J Enghild; Richard W Farndale; Erhard Hohenester; Hideaki Nagase
Structural insights into triple-helical collagen cleavage by matrix metalloproteinase 1.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(31):12461-6.
2012: Samir W Hamaia; Benjamin Némoz; Nicholas Pugh; Nicolas Raynal; Rachael Stone; Dominique Bihan; Donald Gullberg; Richard W Farndale
Mapping of potent and specific binding motifs, GLOGEN and GVOGEA, for integrin α1β1 using collagen toolkits II and III.
The Journal of biological chemistry 2012;287(31):26019-28.
2012: David A Slatter; Rachael Stone; Dominique G Bihan; Sumana Giddu; Gavin E Jarvis; Nicholas Pugh; Richard W Farndale
The properties conferred upon triple-helical collagen-mimetic peptides by the presence of cysteine residues.
Peptides 2012;36(1):86-93.
2012: Thomas J Kunicki; Daniel Diaz; Richard W Farndale; Shirley A Williams; Diane J Nugent
Platelet adhesion to decorin but not collagen I correlates with the integrin α2 dimorphism E534K, the basis of the human platelet alloantigen (HPA)-5 system.
Haematologica 2012;97(5):692-5.
2012: C Y Eleanor Fung; Sarah Jones; Khalid M Naseem; Adwoa Ntrakwah; Richard W Farndale; Martyn P Mahaut-Smith
Platelet Ca(2+) responses coupled to glycoprotein VI and Toll-like receptors persist in the presence of endothelial-derived inhibitors: roles for secondary activation of P2X1 receptors and release from intracellular Ca(2+) stores.
Blood 2012;119(15):3613-21.
2012: T Harma C Brondijk; Richard W Farndale; Dominique Bihan; Eric G Huizinga
Implications for collagen I chain registry from the structure of the collagen von Willebrand factor A3 domain complex.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(14):5253-8.
2012: Gavin E Jarvis; A C Pearce; N Pugh; C E Rudd; J Ware; S P Watson; D Bihan; C J G Ghevaert; Samir W Hamaia; C E Hughes; Richard W Farndale
A role for adhesion and degranulation-promoting adapter protein in collagen-induced platelet activation mediated via integrin α(2) β(1).
Journal of thrombosis and haemostasis : JTH 2012;10(2):268-77.
2012: Huifang Xu; Dominique Bihan; Francis Chang; Richard W Farndale; Paul H. Huang; Birgit Leitinger
Discoidin domain receptors promote α1β1- and α2β1-integrin mediated cell adhesion to collagen by enhancing integrin activation.
PloS one 2012;7(12):e52209.
2012: Simon J Attwood; Richard W Farndale; Samir W Hamaia; Myriam Ouberai; Debdulal Roy; Anna M C Simpson; Rachael Stone; Mark E Welland
A simple bioconjugate attachment protocol for use in single molecule force spectroscopy experiments based on mixed self-assembled monolayers.
International journal of molecular sciences 2012;13(10):13521-41.
2012: Nicholas Pugh; Kjell S Sakariassen; Bill Davis; Gavin E Jarvis; Annelize Koch; Richard W Farndale
The impact of factor Xa inhibition on axial dependent arterial thrombus formation triggered by a tissue factor rich surface.
Journal of thrombosis and thrombolysis 2012;33(1):6-15.
2011: Sandrine Vadon-Le Goff; Nicolas Raynal; Florence Ruggiero; Walter Stöcker; Cécile Bijakowski; Jean-Marie Bourhis; Richard W Farndale; David Hulmes; Daniel Kronenberg; Catherine Moali
Procollagen C-proteinase enhancer stimulates procollagen processing by binding to the C-propeptide region only.
The Journal of biological chemistry 2011;286(45):38932-8.
2011: Alexander David Barrow; Dominique Bihan; Marina Cella; Yongwon Choi; Marco Colonna; Jean-Marie Delaisse; Richard W Farndale; Taesoo Kim; Joseph Lorenzo; Takako Negishi-Koga; Nicholas Pugh; Nicolas Raynal; Jaerang Rho; David A Slatter; Hiroshi Takayanagi; Thomas Levin Andersen; John Trowsdale
OSCAR is a collagen receptor that costimulates osteoclastogenesis in DAP12-deficient humans and mice.
The Journal of clinical investigation 2011;121(9):3505-16.
2011: David A Slatter; Dominique G Bihan; Richard W Farndale
The effect of purity upon the triple-helical stability of collagenous peptides.
Biomaterials 2011;32(27):6621-32.
2011: Eric Boilard; Katherine Larabee; Ruslan Shnayder; Kathleen Jacobs; Richard W Farndale; Jerry Ware; David M Lee
Platelets participate in synovitis via Cox-1-dependent synthesis of prostacyclin independently of microparticle generation.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(7):4361-6.
2011: Patricia Castillo-Briceño; Dominique Bihan; Michael Nilges; Samir Hamaia; José Meseguer; Alfonsa García Ayala; Richard W Farndale; Victoriano Mulero
A role for specific collagen motifs during wound healing and inflammatory response of fibroblasts in the teleost fish gilthead seabream.
Molecular immunology 2011;48(6-7):826-34.
2011: Martin Ruehl; Marion Muche; Christian Freise; Ulrike Erben; Ulf Neumann; Detlef Schuppan; Yury Popov; Walburga Dieterich; Martin Zeitz; Richard W Farndale; Rajan Somasundaram
Hydroxyproline-containing collagen analogs trigger the release and activation of collagen-sequestered proMMP-2 by competition with prodomain-derived peptide P33-42.
Fibrogenesis & tissue repair 2011;4(1):1.
2011: Huifang Xu; Nicolas Raynal; Stavros Stathopoulos; Johanna Myllyharju; Richard W Farndale; Birgit Leitinger
Collagen binding specificity of the discoidin domain receptors: binding sites on collagens II and III and molecular determinants for collagen IV recognition by DDR1.
Matrix biology : journal of the International Society for Matrix Biology 2011;30(1):16-26.
2010: Tijs van Wieringen; Sebastian Kalamajski; Asa Lidén; Dominique Bihan; Bengt Guss; Dick Heinegård; Richard W Farndale; Kristofer Rubin
The streptococcal collagen-binding protein CNE specifically interferes with alphaVbeta3-mediated cellular interactions with triple helical collagen.
The Journal of biological chemistry 2010;285(46):35803-13.
2010: Michèle C Erat; Ulrich Schwarz-Linek; Andrew R Pickford; Richard W Farndale; Iain D Campbell; Ioannis Vakonakis
Implications for collagen binding from the crystallographic structure of fibronectin 6FnI1-2FnII7FnI.
The Journal of biological chemistry 2010;285(44):33764-70.
2010: Jack C Leo; Heli Elovaara; Dominique Bihan; Nicholas Pugh; Sami K Kilpinen; Nicolas Raynal; Mikael Skurnik; Richard W Farndale; Adrian Goldman
First analysis of a bacterial collagen-binding protein with collagen Toolkits: promiscuous binding of YadA to collagens may explain how YadA interferes with host processes.
Infection and immunity 2010;78(7):3226-36.
2010: Nicholas Pugh; Anna M C Simpson; Peter A Smethurst; Philip G de Groot; Nicolas Raynal; Richard W Farndale
Synergism between platelet collagen receptors defined using receptor-specific collagen-mimetic peptide substrata in flowing blood.
Blood 2010;115(24):5069-79.
2010: Armin J Reininger; Isabell Bernlochner; Sandra M Penz; Catherine Ravanat; Peter Smethurst; Richard W Farndale; Christian Gachet; Richard Brandl; Wolfgang Siess
A 2-step mechanism of arterial thrombus formation induced by human atherosclerotic plaques.
Journal of the American College of Cardiology 2010;55(11):1147-58.
2010: T Harma C Brondijk; Talitha Eshuis - de Ruiter; Joost Ballering; Hans Wienk; Robert Jan Lebbink; Hugo van Ingen; Rolf Boelens; Richard W Farndale; Linde Meyaard; Eric G Huizinga
Crystal structure and collagen-binding site of immune inhibitory receptor LAIR-1: unexpected implications for collagen binding by platelet receptor GPVI.
Blood 2010;115(7):1364-73.
2010: Eric Boilard; Peter A Nigrovic; Katherine Larabee; Gerald F M Watts; Jonathan S Coblyn; Michael E Weinblatt; Elena M Massarotti; Eileen Remold-O'Donnell; Richard W Farndale; Jerry Ware; David M Lee
Platelets amplify inflammation in arthritis via collagen-dependent microparticle production.
Science (New York, N.Y.) 2010;327(5965):580-3.
2009: Federico Carafoli; Dominique Bihan; Stavros Stathopoulos; Antonios D Konitsiotis; Marc Kvansakul; Richard W Farndale; Birgit Leitinger; Erhard Hohenester
Crystallographic insight into collagen recognition by discoidin domain receptor 2.
Structure (London, England : 1993) 2009;17(12):1573-81.
2009: Christian Freise; Ulrike Erben; Marion Muche; Richard W Farndale; Martin Zeitz; Rajan Somasundaram; Martin Ruehl
The alpha 2 chain of collagen type VI sequesters latent proforms of matrix-metalloproteinases and modulates their activation and activity.
Matrix biology : journal of the International Society for Matrix Biology 2009;28(8):480-9.
2009: Richard W Farndale
Platelet glycoprotein VI as a mediator of metastasis.
Journal of thrombosis and haemostasis : JTH 2009;7(10):1711-2.
2009: Chris I Jones; Sarah Bray; Stephen F Garner; Jonathan Stephens; Bernard de Bono; Will G J Angenent; David Bentley; Philippa Burns; Alison Coffey; Panos Deloukas; Mark Earthrowl; Richard W Farndale; Marc F Hoylaerts; Kerstin Koch; Angela Rankin; Catherine M Rice; Jane Rogers; Nilesh J Samani; Michael Steward; Adam Walker; Nicholas A Watkins; Jan-Willem Akkerman; Frank Dudbridge; Alison H Goodall; Willem H Ouwehand
A functional genomics approach reveals novel quantitative trait loci associated with platelet signaling pathways.
Blood 2009;114(7):1405-16.
2009: Andrew B Herr; Richard W Farndale
Structural insights into the interactions between platelet receptors and fibrillar collagen.
The Journal of biological chemistry 2009;284(30):19781-5.
2009: Adam Walker; Nicholas Pugh; Stephen F Garner; Jonathan Stephens; Ben Maddox; Willem H Ouwehand; Richard W Farndale; Michael Steward
Single domain antibodies against the collagen signalling receptor glycoprotein VI are inhibitors of collagen induced thrombus formation.
Platelets 2009;20(4):268-76.
2009: Robert Jan Lebbink; Nicolas Raynal; Talitha Eshuis - de Ruiter; Dominique G Bihan; Richard W Farndale; Linde Meyaard
Identification of multiple potent binding sites for human leukocyte associated Ig-like receptor LAIR on collagens II and III.
Matrix biology : journal of the International Society for Matrix Biology 2009;28(4):202-10.
2009: Michèle C Erat; David A Slatter; Edward D Lowe; Christopher J Millard; Richard W Farndale; Iain D Campbell; Ioannis Vakonakis
Identification and structural analysis of type I collagen sites in complex with fibronectin fragments.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(11):4195-200.
2008: Erhard Hohenester; Takako Sasaki; Camilla Giudici; Richard W Farndale; Hans Peter Bächinger
Structural basis of sequence-specific collagen recognition by SPARC.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(47):18273-7.
2008: Camilla Giudici; Nicolas Raynal; Hanna Wiedemann; Wayne A Cabral; Joan C Marini; Rupert Timpl; Hans Peter Bächinger; Richard W Farndale; Takako Sasaki; Ruggero Tenni
Mapping of SPARC/BM-40/osteonectin-binding sites on fibrillar collagens.
The Journal of biological chemistry 2008;283(28):19551-60.
2008: Gavin E Jarvis; Nicolas Raynal; Jonathan P Langford; David J Onley; Allen Andrews; Peter A Smethurst; Richard W Farndale
Identification of a major GpVI-binding locus in human type III collagen.
Blood 2008;111(10):4986-96.
2008: Richard W Farndale; Ton Lisman; Dominique Bihan; Samir W Hamaia; Christiane S Smerling; Nicholas Pugh; Antonios Konitsiotis; Birgit Leitinger; Philip G de Groot; Gavin E Jarvis; Nicolas Raynal
Cell-collagen interactions: the use of peptide Toolkits to investigate collagen-receptor interactions.
Biochemical Society transactions 2008;36(Pt 2):241-50.
2008: Antonios D Konitsiotis; Nicolas Raynal; Dominique Bihan; Erhard Hohenester; Richard W Farndale; Birgit Leitinger
Characterization of high affinity binding motifs for the discoidin domain receptor DDR2 in collagen.
The Journal of biological chemistry 2008;283(11):6861-8.
2007: Chris I Jones; Stephen F Garner; W Angenent; A Bernard; Carlo Berzuini; Philippa Burns; Richard W Farndale; J Hogwood; Angela Rankin; JC Stephens; B D Tom; J Walton; Frank Dudbridge; Willem H Ouwehand; Alison H Goodall
Mapping the platelet profile for functional genomic studies and demonstration of the effect size of the GP6 locus.
Journal of thrombosis and haemostasis : JTH 2007;5(8):1756-65.
2007: Richard W Farndale; David A Slatter; Pia R-M Siljander; Gavin E Jarvis
Platelet receptor recognition and cross-talk in collagen-induced activation of platelets.
Journal of thrombosis and haemostasis : JTH 2007;5 Suppl 1():220-9.
2007: Ton Lisman; Richard W Farndale; P G De Groot
A mechanism to safeguard platelet adhesion under high-shear flow: von Willebrand factor-glycoprotein Ib and integrin alpha2beta1-collagen interactions make complementary, collagen-type-specific contributions to adhesion: a rebuttal.
Journal of thrombosis and haemostasis : JTH 2007;5(6):1338-9; author reply 1340-2.
2007: Mira Tulla; Mikko Huhtala; Juha Jäälinoja; Jarmo Käpylä; Richard W Farndale; Leena Ala-Kokko; Mark S Johnson; Jyrki Heino
Analysis of an ascidian integrin provides new insight into early evolution of collagen recognition.
FEBS letters 2007;581(13):2434-40.
2007: Lynn M Butler; Tom Metson-Scott; Jo Felix; Anita Abhyankar; G Ed Rainger; Richard W Farndale; Steve P Watson; Gerard B Nash
Sequential adhesion of platelets and leukocytes from flowing whole blood onto a collagen-coated surface: requirement for a GpVI-binding site in collagen.
Thrombosis and haemostasis 2007;97(5):814-21.
2007: C Y Eleanor Fung; C Cendana; Richard W Farndale; Martyn P Mahaut-Smith
Primary and secondary agonists can use P2X(1) receptors as a major pathway to increase intracellular Ca(2+) in the human platelet.
Journal of thrombosis and haemostasis : JTH 2007;5(5):910-7.
2007: Peter A Smethurst; David J Onley; Gavin E Jarvis; Marie N O'Connor; C Graham Knight; Andrew B Herr; Willem H Ouwehand; Richard W Farndale
Structural basis for the platelet-collagen interaction: the smallest motif within collagen that recognizes and activates platelet Glycoprotein VI contains two glycine-proline-hydroxyproline triplets.
The Journal of biological chemistry 2007;282(2):1296-304.
2006: Fiona A Lee; Marjolijn van Lier; Ingrid A M Relou; Loraine J Foley; Jan-Willem N Akkerman; Harry F G Heijnen; Richard W Farndale
Lipid rafts facilitate the interaction of PECAM-1 with the glycoprotein VI-FcR gamma-chain complex in human platelets.
The Journal of biological chemistry 2006;281(51):39330-8.
2006: Ton Lisman; Nicolas Raynal; Dafna Groeneveld; Ben Maddox; Anthony R Peachey; Eric G Huizinga; Philip G de Groot; Richard W Farndale
A single high-affinity binding site for von Willebrand factor in collagen III, identified using synthetic triple-helical peptides.
Blood 2006;108(12):3753-6.
2006: Marie N O'Connor; Peter A Smethurst; Lorna W Davies; Lotta Joutsi-Korhonen; David J Onley; Andrew B Herr; Richard W Farndale; Willem H Ouwehand
Selective blockade of glycoprotein VI clustering on collagen helices.
The Journal of biological chemistry 2006;281(44):33505-10.
2006: Nicola S Jennings; Peter A Smethurst; C Graham Knight; Marie N O'Connor; Lotta Joutsi-Korhonen; Prachi Stafford; Jonathan Stephens; Stephen F Garner; Ian J Harmer; Richard W Farndale; Nicholas A Watkins; Willem H Ouwehand
Production of calmodulin-tagged proteins in Drosophila Schneider S2 cells: a novel system for antigen production and phage antibody isolation.
Journal of immunological methods 2006;316(1-2):75-83.
2006: Sylvie Ricard-Blum; Mickael Beraud; Nicolas Raynal; Richard W Farndale; Florence Ruggiero
Structural requirements for heparin/heparan sulfate binding to type V collagen.
The Journal of biological chemistry 2006;281(35):25195-204.
2006: Siham Sabri; Adlen Foudi; Siham Boukour; Brigitte Franc; Sabine Charrier; Martine Jandrot-Perrus; Richard W Farndale; Abdelali JALIL; Mike P Blundell; Elisabeth M Cramer; Fawzia Louache; Najet Debili; Adrian J Thrasher; William Vainchenker
Deficiency in the Wiskott-Aldrich protein induces premature proplatelet formation and platelet production in the bone marrow compartment.
Blood 2006;108(1):134-40.
2006: Robert Jan Lebbink; Talitha Eshuis - de Ruiter; Jelle Adelmeijer; Arjan B Brenkman; Joop M van Helvoort; Manuel Koch; Richard W Farndale; Ton Lisman; Arnoud Sonnenberg; Peter J Lenting; Linde Meyaard
Collagens are functional, high affinity ligands for the inhibitory immune receptor LAIR-1.
The Journal of experimental medicine 2006;203(6):1419-25.
2006: David A Slatter; Loraine A Foley; Anthony R Peachey; Daniel Nietlispach; Richard W Farndale
Rapid synthesis of a register-specific heterotrimeric type I collagen helix encompassing the integrin alpha2beta1 binding site.
Journal of molecular biology 2006;359(2):289-98.
2006: Nicholas A Watkins; Marie N O'Connor; Angela Rankin; Nicola S Jennings; E Wilson; Ian J Harmer; L Davies; Peter A Smethurst; Frank Dudbridge; Richard W Farndale; Willem H Ouwehand
Definition of novel GP6 polymorphisms and major difference in haplotype frequencies between populations by a combination of in-depth exon resequencing and genotyping with tag single nucleotide polymorphisms.
Journal of thrombosis and haemostasis : JTH 2006;4(6):1197-205.
2006: Marie N O'Connor; Peter A Smethurst; Richard W Farndale; Willem H Ouwehand
Gain- and loss-of-function mutants confirm the importance of apical residues to the primary interaction of human glycoprotein VI with collagen.
Journal of thrombosis and haemostasis : JTH 2006;4(4):869-73.
2006: Richard W Farndale
Collagen-induced platelet activation.
Blood cells, molecules & diseases 2006;36(2):162-5.
2006: Nicolas Raynal; Samir W Hamaia; Pia R-M Siljander; Ben Maddox; Anthony R Peachey; Rafael Fernandez; Loraine J Foley; David A Slatter; Gavin E Jarvis; Richard W Farndale
Use of synthetic peptides to locate novel integrin alpha2beta1-binding motifs in human collagen III.
The Journal of biological chemistry 2006;281(7):3821-31.
2005: Darren L Hughes; Prachi Stafford; Samir W Hamaia; lan J Harmer; Anne Schoolmeester; Hans Deckmyn; Richard W Farndale; Willem H Ouwehand; Nicholas A Watkins
Platelet integrin alpha2 I-domain specific antibodies produced via domain specific DNA vaccination combined with variable gene phage display.
Thrombosis and haemostasis 2005;94(6):1318-26.
2005: Marjolijn van Lier; F Lee; Richard W Farndale; Gertie Gorter; S Verhoef; Yoshiko Ohno-Iwashita; Jan-Willem N Akkerman; Harry F G Heijnen
Adhesive surface determines raft composition in platelets adhered under flow.
Journal of thrombosis and haemostasis : JTH 2005;3(11):2514-25.
2005: Rocio Riba; Marzieh Sharifi; Richard W Farndale; Khalid M Naseem
Regulation of platelet guanylyl cyclase by collagen: evidence that Glycoprotein VI mediates platelet nitric oxide synthesis in response to collagen.
Thrombosis and haemostasis 2005;94(2):395-403.
2005: C Y Eleanor Fung; Charles A Brearley; Richard W Farndale; Martyn P Mahaut-Smith
A major role for P2X1 receptors in the early collagen-evoked intracellular Ca2+ responses of human platelets.
Thrombosis and haemostasis 2005;94(1):37-40.
2005: Sandra Penz; Armin J Reininger; Richard Brandl; Pankaj Goyal; Tamer Rabie; Isabell Bernlochner; Enno Rother; Christine Goetz; Bernd Engelmann; Peter A Smethurst; Willem H Ouwehand; Richard W Farndale; Bernhard Nieswandt; Wolfgang Siess
Human atheromatous plaques stimulate thrombus formation by activating platelet glycoprotein VI.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(8):898-909.
2004: Jarmo Käpylä; Juha Jäälinoja; Mira Tulla; Joni Ylöstalo; Liisa Nissinen; Tiina Viitasalo; Piia Vehviläinen; Varpu Marjomäki; Petri Nykvist; Anna-Marja Säämänen; Richard W Farndale; David E Birk; Leena Ala-Kokko; Jyrki Heino
The fibril-associated collagen IX provides a novel mechanism for cell adhesion to cartilaginous matrix.
The Journal of biological chemistry 2004;279(49):51677-87.
2004: Siham Sabri; Martine Jandrot-Perrus; Jacques Bertoglio; Richard W Farndale; Véronique Mansat-De Mas; Najet Debili; William Vainchenker
Differential regulation of actin stress fiber assembly and proplatelet formation by alpha2beta1 integrin and GPVI in human megakaryocytes.
Blood 2004;104(10):3117-25.
2004: Pia R-M Siljander; Samir W Hamaia; Anthony R Peachey; David A Slatter; Peter A Smethurst; Willem H Ouwehand; C Graham Knight; Richard W Farndale
Integrin activation state determines selectivity for novel recognition sites in fibrillar collagens.
The Journal of biological chemistry 2004;279(46):47763-72.
2004: Alexander D Barrow; Emmanuelle Astoul; Andres Floto; Gary Brooke; Ingrid A M Relou; Nicola S Jennings; Kenneth G C Smith; Willem H Ouwehand; Richard W Farndale; Denis R Alexander; John Trowsdale
Cutting edge: TREM-like transcript-1, a platelet immunoreceptor tyrosine-based inhibition motif encoding costimulatory immunoreceptor that enhances, rather than inhibits, calcium signaling via SHP-2.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(10):5838-42.
2004: Richard W Farndale; Jan J Sixma; Michael J Barnes; Philip G de Groot
The role of collagen in thrombosis and hemostasis.
Journal of thrombosis and haemostasis : JTH 2004;2(4):561-73.
2004: Lotta Joutsi-Korhonen; Sandy Preston; Peter A Smethurst; Martin J W IJsseldijk; Elisabeth Schaffner-Reckinger; Kathryn Armour; Nicholas A Watkins; Michael R Clark; Philip G de Groot; Richard W Farndale; Willem H Ouwehand; Lorna M Williamson
The effect of recombinant IgG antibodies against the leucine-33 form of the platelet beta3 integrin (HPA-1a) on platelet function.
Thrombosis and haemostasis 2004;91(4):743-54.
2004: Pia R-M Siljander; Imke C A Munnix; Peter A Smethurst; Hans Deckmyn; Theo Lindhout; Willem H Ouwehand; Richard W Farndale; Johan W M Heemskerk
Platelet receptor interplay regulates collagen-induced thrombus formation in flowing human blood.
Blood 2004;103(4):1333-41.
2004: Peter A Smethurst; Lotta Joutsi-Korhonen; Marie N O'Connor; Erica Wilson; Nicola S Jennings; Stephen F Garner; Yanjun Zhang; C Graham Knight; Timothy R Dafforn; Ashley Buckle; Martin J W IJsseldijk; Philip G de Groot; Nicholas A Watkins; Richard W Farndale; Willem H Ouwehand
Identification of the primary collagen-binding surface on human glycoprotein VI by site-directed mutagenesis and by a blocking phage antibody.
Blood 2004;103(3):903-11.
2004: Jonas Emsley; C Graham Knight; Richard W Farndale; Michael J Barnes
Structure of the integrin alpha2beta1-binding collagen peptide.
Journal of molecular biology 2004;335(4):1019-28.
2004: C Graham Knight; Catherine M Onley; Richard W Farndale
Peptide synthesis in the study of collagen-platelet interactions.
Methods in molecular biology (Clifton, N.J.) 2004;273():349-64.
2004: Richard W Farndale; Philip G Hargreaves; Joanna L Dietrich; Rosemary J Keogh
Measurement of platelet arachidonic acid metabolism.
Methods in molecular biology (Clifton, N.J.) 2004;272():121-33.
2003: Judith Lahav; Eveline M Wijnen; Oded Hess; Samir W Hamaia; Delia Griffiths; Michael Makris; C Graham Knight; David W Essex; Richard W Farndale
Enzymatically catalyzed disulfide exchange is required for platelet adhesion to collagen via integrin alpha2beta1.
Blood 2003;102(6):2085-92.
2003: Stéephanie Perret; Johannes A Eble; Pia R-M Siljander; Christine Merle; Richard W Farndale; Manfred Theisen; Florence Ruggiero
Prolyl hydroxylation of collagen type I is required for efficient binding to integrin alpha 1 beta 1 and platelet glycoprotein VI but not to alpha 2 beta 1.
The Journal of biological chemistry 2003;278(32):29873-9.
2003: Lotta Joutsi-Korhonen; Peter A Smethurst; Angela Rankin; Elaine Gray; Martin J W IJsseldijk; Catherine M Onley; Nicholas A Watkins; Lorna M Williamson; Alison H Goodall; Philip G de Groot; Richard W Farndale; Willem H Ouwehand
The low-frequency allele of the platelet collagen signaling receptor glycoprotein VI is associated with reduced functional responses and expression.
Blood 2003;101(11):4372-9.
2003: Wan-Ming Zhang; Jarmo Käpylä; J Santeri Puranen; C Graham Knight; Carl-Fredrik Tiger; Olli Pentikäinen; Mark S Johnson; Richard W Farndale; Jyrki Heino; Donald Gullberg
alpha 11beta 1 integrin recognizes the GFOGER sequence in interstitial collagens.
The Journal of biological chemistry 2003;278(9):7270-7.
2003: Richard W Farndale; Pia R-M Siljander; David J Onley; Pavithra Sundaresan; C Graham Knight; Michael J Barnes
Collagen-platelet interactions: recognition and signalling.
Biochemical Society symposium 2003;(70):81-94.
2002: Catherine M Elton; Peter A Smethurst; Paul Eggleton; Richard W Farndale
Physical and functional interaction between cell-surface calreticulin and the collagen receptors integrin alpha2beta1 and glycoprotein VI in human platelets.
Thrombosis and haemostasis 2002;88(4):648-54.
2002: Judith Lahav; Kerstin Jurk; Oded Hess; Michael J Barnes; Richard W Farndale; Jacob Luboshitz; Beate Kehrel
Sustained integrin ligation involves extracellular free sulfhydryls and enzymatically catalyzed disulfide exchange.
Blood 2002;100(7):2472-8.
2002: Pavithra Sundaresan; Richard W Farndale
P38 mitogen-activated protein kinase dephosphorylation is regulated by protein phosphatase 2A in human platelets activated by collagen.
FEBS letters 2002;528(1-3):139-44.
2002: Martin Ruehl; Rajan Somasundaram; Ines Schoenfelder; Richard W Farndale; C Graham Knight; Monika Schmid; Renate Ackermann; Ernst-Otto Riecken; Martin Zeitz; Detlef Schuppan
The epithelial mitogen keratinocyte growth factor binds to collagens via the consensus sequence glycine-proline-hydroxyproline.
The Journal of biological chemistry 2002;277(30):26872-8.
2002: Alexis Aquilina; Michelle Korda; Jeffrey M Bergelson; Martin J Humphries; Richard W Farndale; Danny S Tuckwell
A novel gain-of-function mutation of the integrin alpha2 VWFA domain.
European journal of biochemistry / FEBS 2002;269(4):1136-44.
2001: Pia R-M Siljander; Richard W Farndale; Marion A H Feijge; Paul Comfurius; S Kos; Edouard M Bevers; Johan W M Heemskerk
Platelet adhesion enhances the glycoprotein VI-dependent procoagulant response: Involvement of p38 MAP kinase and calpain.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(4):618-27.
2001: M Achison; C M Elton; P G Hargreaves; C Graham Knight; Michael J Barnes; Richard W Farndale
Integrin-independent tyrosine phosphorylation of p125(fak) in human platelets stimulated by collagen.
The Journal of biological chemistry 2001;276(5):3167-74.
2000: Johan W M Heemskerk; Pia R-M Siljander; Edouard M Bevers; Richard W Farndale; Theo Lindhout
Receptors and signalling mechanisms in the procoagulant response of platelets.
Platelets 2000;11(6):301-6.
2000: Danny S Tuckwell; L Smith; M Korda; Janet Askari; S Santoso; Michael J Barnes; Richard W Farndale; Martin J Humphries
Monoclonal antibodies identify residues 199-216 of the integrin alpha2 vWFA domain as a functionally important region within alpha2beta1.
The Biochemical journal 2000;350 Pt 2():485-93.
2000: David J Onley; C Graham Knight; Danny S Tuckwell; Michael J Barnes; Richard W Farndale
Micromolar Ca2+ concentrations are essential for Mg2+-dependent binding of collagen by the integrin alpha 2beta 1 in human platelets.
The Journal of biological chemistry 2000;275(32):24560-4.
2000: Florence Niedergang; Andrés Alcover; C Graham Knight; Richard W Farndale; Michael J Barnes; Ivo M B Francischetti; Cassian Bon; Mireille Leduc
Convulxin binding to platelet receptor GPVI: competition with collagen related peptides.
Biochemical and biophysical research communications 2000;273(1):246-50.
2000: Jonas Emsley; C Graham Knight; Richard W Farndale; Michael J Barnes; Robert C Liddington
Structural basis of collagen recognition by integrin alpha2beta1.
Cell 2000;101(1):47-56.
2000: C Graham Knight; LF Morton; Anthony R Peachey; Danny S Tuckwell; Richard W Farndale; Michael J Barnes
The collagen-binding A-domains of integrins alpha(1)beta(1) and alpha(2)beta(1) recognize the same specific amino acid sequence, GFOGER, in native (triple-helical) collagens.
The Journal of biological chemistry 2000;275(1):35-40.
1999: Michael J Barnes; Richard W Farndale
Collagens and atherosclerosis.
Experimental gerontology 1999;34(4):513-25.
1999: Johan W M Heemskerk; Pia R-M Siljander; Wim M J Vuist; Githa Breikers; Chris P M Reutelingsperger; Michael J Barnes; C Graham Knight; Riitta Lassila; Richard W Farndale
Function of glycoprotein VI and integrin alpha2beta1 in the procoagulant response of single, collagen-adherent platelets.
Thrombosis and haemostasis 1999;81(5):782-92.
1999: J Asselin; C Graham Knight; Richard W Farndale; Michael J Barnes; Steve P Watson
Monomeric (glycine-proline-hydroxyproline)10 repeat sequence is a partial agonist of the platelet collagen receptor glycoprotein VI.
The Biochemical journal 1999;339 ( Pt 2)():413-8.
1999: C Graham Knight; LF Morton; David J Onley; Anthony R Peachey; T Ichinohe; M Okuma; Richard W Farndale; Michael J Barnes
Collagen-platelet interaction: Gly-Pro-Hyp is uniquely specific for platelet Gp VI and mediates platelet activation by collagen.
Cardiovascular research 1999;41(2):450-7.
1998: C Graham Knight; LF Morton; David J Onley; Anthony R Peachey; Anthea J Messent; Peter A Smethurst; Danny S Tuckwell; Richard W Farndale; Michael J Barnes
Identification in collagen type I of an integrin alpha2 beta1-binding site containing an essential GER sequence.
The Journal of biological chemistry 1998;273(50):33287-94.
1998: Michael J Barnes; C Graham Knight; Richard W Farndale
The collagen-platelet interaction.
Current opinion in hematology 1998;5(5):314-20.
1998: Beate Kehrel; S Wierwille; Kenneth J Clemetson; O Anders; M Steiner; C Graham Knight; Richard W Farndale; M Okuma; Michael J Barnes
Glycoprotein VI is a major collagen receptor for platelet activation: it recognizes the platelet-activating quaternary structure of collagen, whereas CD36, glycoprotein IIb/IIIa, and von Willebrand factor do not.
Blood 1998;91(2):491-9.
1997: Jonathan M Gibbins; M Okuma; Richard W Farndale; M Barnes; Steve P Watson
Glycoprotein VI is the collagen receptor in platelets which underlies tyrosine phosphorylation of the Fc receptor gamma-chain.
FEBS letters 1997;413(2):255-9.
1997: Johan W M Heemskerk; Marion A H Feijge; Stewart O Sage; Richard W Farndale
Human platelet activation is inhibited upstream of the activation of phospholipase A2 by U73343.
Biochemical pharmacology 1997;53(9):1257-62.
1997: LF Morton; Anthony R Peachey; C Graham Knight; Richard W Farndale; Michael J Barnes
The platelet reactivity of synthetic peptides based on the collagen III fragment alpha1(III)CB4. Evidence for an integrin alpha2beta1 recognition site involving residues 522-528 of the alpha1(III) collagen chain.
The Journal of biological chemistry 1997;272(17):11044-8.
1997: J Asselin; Jonathan M Gibbins; M Achison; Y H Lee; L F Morton; Richard W Farndale; Michael J Barnes; Steve P Watson
A collagen-like peptide stimulates tyrosine phosphorylation of syk and phospholipase C gamma2 in platelets independent of the integrin alpha2beta1.
Blood 1997;89(4):1235-42.
1997: J W Heemskerk; Richard W Farndale; S O Sage
Effects of U73122 and U73343 on human platelet calcium signalling and protein tyrosine phosphorylation.
Biochimica et biophysica acta 1997;1355(1):81-8.
1996: P G Hargreaves; S Jenner; J E Merritt; Stewart O Sage; Richard W Farndale
Ionomycin-stimulated arachidonic acid release in human platelets: a role for protein kinase C and tyrosine phosphorylation.
Thrombosis and haemostasis 1996;76(2):248-52.
1996: Jonathan M Gibbins; J Asselin; Richard W Farndale; M Barnes; Che-Leung Law; Steve P Watson
Tyrosine phosphorylation of the Fc receptor gamma-chain in collagen-stimulated platelets.
The Journal of biological chemistry 1996;271(30):18095-9.
1996: Jeremy Saklatvala; L Rawlinson; R J Waller; Simon J Sarsfield; J C Lee; L F Morton; Michael J Barnes; Richard W Farndale
Role for p38 mitogen-activated protein kinase in platelet aggregation caused by collagen or a thromboxane analogue.
The Journal of biological chemistry 1996;271(12):6586-9.
1996: S Jenner; Richard W Farndale; Stewart O Sage
Wortmannin inhibits store-mediated calcium entry and protein tyrosine phosphorylation in human platelets.
FEBS letters 1996;381(3):249-51.
1996: M Achison; C Joel; P G Hargreaves; Stewart O Sage; Michael J Barnes; Richard W Farndale
Signals elicited from human platelets by synthetic, triple helical, collagen-like peptides.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 1996;7(2):149-52.
1996: Richard W Farndale; C S Napthine; Richard J Evans; L J Hayes; M Fred Heath
The inhibition of adenylate cyclase in equine platelets by collagen and by platelet-activating factor.
Platelets 1996;7(1-2):43-6.
1996: Michael J Barnes; C G Knight; Richard W Farndale
The use of collagen-based model peptides to investigate platelet-reactive sequences in collagen.
Biopolymers 1996;40(4):383-97.
1995: Richard W Farndale; M J Barnes
Transmembrane signalling: protein tyrosine phosphorylation and platelet activation.
Equine veterinary journal 1995;27(6):407-10.
1995: David J Grainger; L Wakefield; H W Bethell; Richard W Farndale; James C Metcalfe
Release and activation of platelet latent TGF-beta in blood clots during dissolution with plasmin.
Nature medicine 1995;1(9):932-7.
1995: LF Morton; P G Hargreaves; Richard W Farndale; R D Young; Michael J Barnes
Integrin alpha 2 beta 1-independent activation of platelets by simple collagen-like peptides: collagen tertiary (triple-helical) and quaternary (polymeric) structures are sufficient alone for alpha 2 beta 1-independent platelet reactivity.
The Biochemical journal 1995;306 ( Pt 2)():337-44.
1994: P Sargeant; Richard W Farndale; Stewart O Sage
The imidazole antimycotics econazole and miconazole reduce agonist-evoked protein-tyrosine phosphorylation and evoke membrane depolarisation in human platelets: cautions for their use in studying Ca2+ signalling pathways.
Cell calcium 1994;16(5):413-8.
1994: S Jenner; Richard W Farndale; Stewart O Sage
The effect of calcium-store depletion and refilling with various bivalent cations on tyrosine phosphorylation and Mn2+ entry in fura-2-loaded human platelets.
The Biochemical journal 1994;303 ( Pt 2)():337-9.
1994: P G Hargreaves; E F Licking; P Sargeant; Stewart O Sage; Michael J Barnes; Richard W Farndale
The tyrosine kinase inhibitors, genistein and methyl 2,5-dihydroxycinnamate, inhibit the release of (3H)arachidonate from human platelets stimulated by thrombin or collagen.
Thrombosis and haemostasis 1994;72(4):634-42.
1994: S O Sage; P Sargeant; S Jenner; Richard W Farndale
Tyrosine phosphorylation and Ca2+ influx. A further mechanism for store-dependent Ca2+ entry?
Trends in pharmacological sciences 1994;15(8):282.
1994: P Sargeant; Richard W Farndale; Stewart O Sage
Calcium store depletion in dimethyl BAPTA-loaded human platelets increases protein tyrosine phosphorylation in the absence of a rise in cytosolic calcium.
Experimental physiology 1994;79(2):269-72.
1993: P Sargeant; Richard W Farndale; Stewart O Sage
ADP- and thapsigargin-evoked Ca2+ entry and protein-tyrosine phosphorylation are inhibited by the tyrosine kinase inhibitors genistein and methyl-2,5-dihydroxycinnamate in fura-2-loaded human platelets.
The Journal of biological chemistry 1993;268(24):18151-6.
1993: Jonathan R Sandy; Murray C Meikle; Richard W Farndale
Pertussis toxin-sensitive activation of phospholipase A2 can be resolved from phosphoinositidase C in primary cultures of mouse osteoblasts using indomethacin.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1993;8(5):543-52.
1993: Jonathan R Sandy; Richard W Farndale; Murray C Meikle
Recent advances in understanding mechanically induced bone remodeling and their relevance to orthodontic theory and practice.
American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics 1993;103(3):212-22.
1993: P Sargeant; Richard W Farndale; Stewart O Sage
The tyrosine kinase inhibitors methyl 2,5-dihydroxycinnamate and genistein reduce thrombin-evoked tyrosine phosphorylation and Ca2+ entry in human platelets.
FEBS letters 1993;315(3):242-6.
1992: Richard W Farndale; A B Winkler; B R Martin; Michael J Barnes
Inhibition of human platelet adenylate cyclase by collagen fibres. Effect of collagen is additive with that of adrenaline, but interactive with that of thrombin.
The Biochemical journal 1992;282 ( Pt 1)():25-32.
1991: Jonathan R Sandy; Richard W Farndale
Second messengers: regulators of mechanically-induced tissue remodelling.
European journal of orthodontics 1991;13(4):271-8.
1991: Jonathan R Sandy; Murray C Meikle; B R Martin; Richard W Farndale
Leukotriene B4 increases intracellular calcium concentration and phosphoinositide metabolism in mouse osteoblasts via cyclic adenosine 3',5'-monophosphate-independent pathways.
Endocrinology 1991;129(2):582-90.
1991: I A Wadman; Richard W Farndale; B R Martin
Evidence for regulation of human platelet adenylate cyclase by phosphorylation. Inhibition by ATP and guanosine 5'-[beta-thio]diphosphate occur by distinct mechanisms.
The Biochemical journal 1991;276 ( Pt 3)():621-30.
1989: Jonathan R Sandy; Sajeda Meghji; Richard W Farndale; Murray C Meikle
Dual elevation of cyclic AMP and inositol phosphates in response to mechanical deformation of murine osteoblasts.
Biochimica et biophysica acta 1989;1010(2):265-9.
1988: M Jacobs; M P Thelen; Richard W Farndale; M C Astle; P H Rubery
Specific guanine nucleotide binding by membranes from Cucurbita pepo seedlings.
Biochemical and biophysical research communications 1988;155(3):1478-84.
1988: B H Knowles; Richard W Farndale
Activation of insect cell adenylate cyclase by Bacillus thuringiensis delta-endotoxins and melittin. Toxicity is independent of cyclic AMP.
The Biochemical journal 1988;253(1):235-41.
1988: Richard W Farndale; Jonathan R Sandy; Susan J Atkinson; S R Pennington; Sajeda Meghji; Murray C Meikle
Parathyroid hormone and prostaglandin E2 stimulate both inositol phosphates and cyclic AMP accumulation in mouse osteoblast cultures.
The Biochemical journal 1988;252(1):263-8.