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Amjad Farooq

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Caleb B McDonald; David C Mikles; Kenneth L Seldeen; Vikas Bhat; Brian J Deegan; Dmitry Kurouski; Igor K Lednev; Amjad Farooq
Structural landscape of the proline-rich domain of Sos1 nucleotide exchange factor.
Michael Hoosien; Todd E Miller; Robert J Myerburg; Thai V Pham; Marcel J Smets; Ming-Lon Young; Lisa Baumbach; Mary Ellen Ahearn; Amjad Farooq; Nanette H Bishopric
Dysfunctional potassium channel subunit interaction as a novel mechanism of long QT syndrome.
Caleb B McDonald; David C Mikles; Kenneth L Seldeen; Nawal Zafar; Jordan E Balke; Vikas Bhat; Brian J Deegan; Jimmy El Hokayem; Amjad Farooq
Allostery mediates ligand binding to Grb2 adaptor in a mutually exclusive manner.

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All Publications

2013: Caleb B McDonald; David C Mikles; Kenneth L Seldeen; Vikas Bhat; Brian J Deegan; Dmitry Kurouski; Igor K Lednev; Amjad Farooq
Structural landscape of the proline-rich domain of Sos1 nucleotide exchange factor.
Biophysical chemistry 2013;175-176():54-62.
2013: Michael Hoosien; Todd E Miller; Robert J Myerburg; Thai V Pham; Marcel J Smets; Ming-Lon Young; Lisa Baumbach; Mary Ellen Ahearn; Amjad Farooq; Nanette H Bishopric
Dysfunctional potassium channel subunit interaction as a novel mechanism of long QT syndrome.
Heart rhythm : the official journal of the Heart Rhythm Society 2013;10(5):728-37.
2013: Caleb B McDonald; David C Mikles; Kenneth L Seldeen; Nawal Zafar; Jordan E Balke; Vikas Bhat; Brian J Deegan; Jimmy El Hokayem; Amjad Farooq
Allostery mediates ligand binding to Grb2 adaptor in a mutually exclusive manner.
Journal of molecular recognition : JMR 2013;26(2):92-103.
2012: Vikas Bhat; Brian J Deegan; Dmitry Kurouski; Igor K Lednev; Caleb B McDonald; David C Mikles; Max B Olenick; Kenneth L Seldeen; Amjad Farooq
Acidic pH promotes oligomerization and membrane insertion of the BclXL apoptotic repressor.
Archives of biochemistry and biophysics 2012;528(1):32-44.
2012: Christian J Gaffney; Uri Gat; Alicia Golden; Dror Hilman; Johji Inazawa; Virginia Mazack; Tomoki Muramatsu; Tsutomu Oka; David J Carey; Amjad Farooq; Gerard Tromp; Marius Sudol
Identification, basic characterization and evolutionary analysis of differentially spliced mRNA isoforms of human YAP1 gene.
Gene 2012;509(2):215-22.
2012: Caleb B McDonald; David C Mikles; Zafar Nawaz; Zaidoun Salah; Kenneth L Seldeen; Marius Sudol; Rami I Aqeilan; Tomer Bar-Mag; Vikas Bhat; Laura Buffa; Brian J Deegan; Arun Malhotra; Amjad Farooq
Biophysical basis of the binding of WWOX tumor suppressor to WBP1 and WBP2 adaptors.
Journal of molecular biology 2012;422(1):58-74.
2012: Marius Sudol; Denis C Shields; Amjad Farooq
Structures of YAP protein domains reveal promising targets for development of new cancer drugs.
Seminars in cell & developmental biology 2012;23(7):827-33.
2012: Marius Sudol; Caleb B McDonald; Amjad Farooq
Molecular insights into the WW domain of the Golabi-Ito-Hall syndrome protein PQBP1.
FEBS letters 2012;586(17):2795-9.
2012: Caleb B McDonald; David C Mikles; Kenneth L Seldeen; Vikas Bhat; Brian J Deegan; Amjad Farooq
Bivalent binding drives the formation of the Grb2-Gab1 signaling complex in a noncooperative manner.
The FEBS journal 2012;279(12):2156-73.
2012: Caleb B McDonald; David C Mikles; Kenneth L Seldeen; Jordan E Balke; Vikas Bhat; Brian J Deegan; Amjad Farooq
Multivalent binding and facilitated diffusion account for the formation of the Grb2-Sos1 signaling complex in a cooperative manner.
Biochemistry 2012;51(10):2122-35.
2012: Vikas Bhat; Brian J Deegan; Caleb B McDonald; David C Mikles; Kenneth L Seldeen; Margaret L Bates; Amjad Farooq
Ligand binding and membrane insertion compete with oligomerization of the BclXL apoptotic repressor.
Journal of molecular biology 2012;416(1):57-77.
2012: S Rao; F Wu; Wayne Balkan; C D Fahrenholtz; Amjad Farooq; L S Lyons; Kerry L Burnstein
A novel nuclear role for the Vav3 nucleotide exchange factor in androgen receptor coactivation in prostate cancer.
Oncogene 2012;31(6):716-27.
2011: Caleb B McDonald; Samantha K N McIntosh; David C Mikles; Zafar Nawaz; Ali M Saeed; Kenneth L Seldeen; Marius Sudol; Vikas Bhat; Laura Buffa; Brian J Deegan; Amjad Farooq
Biophysical analysis of binding of WW domains of the YAP2 transcriptional regulator to PPXY motifs within WBP1 and WBP2 adaptors.
Biochemistry 2011;50(44):9616-27.
2011: Brian J Deegan; Vikas Bhat; Anna M Bona; Caleb B McDonald; David C Mikles; Kenneth L Seldeen; Amjad Farooq
Structural and thermodynamic consequences of the replacement of zinc with environmental metals on estrogen receptor α-DNA interactions.
Journal of molecular recognition : JMR 2011;24(6):1007-17.
2011: Caleb B McDonald; Kenneth L Seldeen; Brian J Deegan; Vikas Bhat; Amjad Farooq
Binding of the cSH3 domain of Grb2 adaptor to two distinct RXXK motifs within Gab1 docker employs differential mechanisms.
Journal of molecular recognition : JMR 2011;24(4):585-96.
2011: Kenneth L Seldeen; Vikas Bhat; Brian J Deegan; Caleb B McDonald; David C Mikles; Amjad Farooq
Energetic coupling along an allosteric communication channel drives the binding of Jun-Fos heterodimeric transcription factor to DNA.
The FEBS journal 2011;278(12):2090-104.
2011: Alexander J Abrams; Amjad Farooq; Gaofeng Wang
S-nitrosylation of ApoE in Alzheimer's disease.
Biochemistry 2011;50(17):3405-7.
2011: Brian J Deegan; Vikas Bhat; Kenneth L Seldeen; Caleb B McDonald; Amjad Farooq
Genetic variations within the ERE motif modulate plasticity and energetics of binding of DNA to the ERα nuclear receptor.
Archives of biochemistry and biophysics 2011;507(2):262-70.
2011: Stephan Zuchner; Julia Dallman; Rong Wen; Gary Beecham; Adam Naj; Amjad Farooq; Martin A Kohli; Patrice L Whitehead; William F Hulme; Ioanna Konidari; Yvonne Jemimah Edwards; Guiqing Cai; Inga Peter; David Seo; Joseph Buxbaum; Jonathan L Haines; S Blanton; Juan I. Young; Eduardo C Alfonso; Jeffery Vance; Byron Lam; Margaret A Peričak-Vance
Whole-exome sequencing links a variant in DHDDS to retinitis pigmentosa.
American journal of human genetics 2011;88(2):201-6.
2010: Asli Sirmaci; Tom Walsh; Hatice Akay; Michail Spiliopoulos; Yildirim Bayezit Sakalar; Aylin Hasanefendioğlu-Bayrak; Duygu Duman; Amjad Farooq; Mary-Claire King; Mustafa Tekin
MASP1 mutations in patients with facial, umbilical, coccygeal, and auditory findings of Carnevale, Malpuech, OSA, and Michels syndromes.
American journal of human genetics 2010;87(5):679-86.
2010: Brian J Deegan; Kenneth L Seldeen; Caleb B McDonald; Vikas Bhat; Amjad Farooq
Binding of the ERalpha nuclear receptor to DNA is coupled to proton uptake.
Biochemistry 2010;49(29):5978-88.
2010: Victor Tapia; Emilia Nicolaescu; Caleb B McDonald; Valeria Musi; Tsutomu Oka; Yujin Inayoshi; Adam C Satteson; Virginia Mazack; Jasper Humbert; Christian J Gaffney; Monique Beullens; Charles E Schwartz; Christiane Landgraf; Rudolf Volkmer; Annalisa Pastore; Amjad Farooq; Mathieu Bollen; Marius Sudol
Y65C missense mutation in the WW domain of the Golabi-Ito-Hall syndrome protein PQBP1 affects its binding activity and deregulates pre-mRNA splicing.
The Journal of biological chemistry 2010;285(25):19391-401.
2010: Kenneth L Seldeen; Caleb B McDonald; Brian J Deegan; Vikas Bhat; Amjad Farooq
Dissecting the role of leucine zippers in the binding of bZIP domains of Jun transcription factor to DNA.
Biochemical and biophysical research communications 2010;394(4):1030-5.
2010: Caleb B McDonald; Kenneth L Seldeen; Brian J Deegan; Vikas Bhat; Amjad Farooq
Assembly of the Sos1-Grb2-Gab1 ternary signaling complex is under allosteric control.
Archives of biochemistry and biophysics 2010;494(2):216-25.
2010: Hassan Al-Ali; Megan E Rieger; Kenneth L Seldeen; Thomas K Harris; Amjad Farooq; Karoline J Briegel
Biophysical characterization reveals structural disorder in the developmental transcriptional regulator LBH.
Biochemical and biophysical research communications 2010;391(1):1104-9.
2009: Kenneth L Seldeen; Caleb B McDonald; Brian J Deegan; Vikas Bhat; Amjad Farooq
DNA plasticity is a key determinant of the energetics of binding of Jun-Fos heterodimeric transcription factor to genetic variants of TGACGTCA motif.
Biochemistry 2009;48(51):12213-22.
2009: Caleb B McDonald; Kenneth L Seldeen; Brian J Deegan; Amjad Farooq
SH3 domains of Grb2 adaptor bind to PXpsiPXR motifs within the Sos1 nucleotide exchange factor in a discriminate manner.
Biochemistry 2009;48(19):4074-85.
2009: Kenneth L Seldeen; Caleb B McDonald; Brian J Deegan; Amjad Farooq
Single nucleotide variants of the TGACTCA motif modulate energetics and orientation of binding of the Jun-Fos heterodimeric transcription factor.
Biochemistry 2009;48(9):1975-83.
2008: Kenneth L Seldeen; Caleb B McDonald; Brian J Deegan; Amjad Farooq
Evidence that the bZIP domains of the Jun transcription factor bind to DNA as monomers prior to folding and homodimerization.
Archives of biochemistry and biophysics 2008;480(2):75-84.
2008: Caleb B McDonald; Kenneth L Seldeen; Brian J Deegan; Amjad Farooq
Structural basis of the differential binding of the SH3 domains of Grb2 adaptor to the guanine nucleotide exchange factor Sos1.
Archives of biochemistry and biophysics 2008;479(1):52-62.
2008: Kenneth L Seldeen; Caleb B McDonald; Brian J Deegan; Amjad Farooq
Thermodynamic analysis of the heterodimerization of leucine zippers of Jun and Fos transcription factors.
Biochemical and biophysical research communications 2008;375(4):634-8.
2008: Caleb B McDonald; Kenneth L Seldeen; Brian J Deegan; Marc S Lewis; Amjad Farooq
Grb2 adaptor undergoes conformational change upon dimerization.
Archives of biochemistry and biophysics 2008;475(1):25-35.
2008: Kenneth L Seldeen; Caleb B McDonald; Brian J Deegan; Amjad Farooq
Coupling of folding and DNA-binding in the bZIP domains of Jun-Fos heterodimeric transcription factor.
Archives of biochemistry and biophysics 2008;473(1):48-60.
2006: Victoria P. Ramsauer; Vanessa Pino; Amjad Farooq; Coralie A Carothers Carraway; Pedro J I Salas; Kermit L Carraway
Muc4-ErbB2 complex formation and signaling in polarized CACO-2 epithelial cells indicate that Muc4 acts as an unorthodox ligand for ErbB2.
Molecular biology of the cell 2006;17(7):2931-41.
2006: Chengmin Qian; Xueqi Wang; Karishma L Manzur; Amjad Farooq; Lei Zeng; Rong Wang; Ming-Ming Zhou
Structural insights of the specificity and catalysis of a viral histone H3 lysine 27 methyltransferase.
Journal of molecular biology 2006;359(1):86-96.
2005: Qiang Zhang; Michaela Muller; Can Hao Chen; Lei Zeng; Amjad Farooq; Ming-Ming Zhou
New insights into the catalytic activation of the MAPK phosphatase PAC-1 induced by its substrate MAPK ERK2 binding.
Journal of molecular biology 2005;354(4):777-88.
2005: Marius Sudol; Claudia C Recinos; Jennifer Abraczinskas; Jasper Humbert; Amjad Farooq
WW or WoW: the WW domains in a union of bliss.
IUBMB life 2005;57(12):773-8.
2005: Chengmin Qian; Qiang Zhang; Xueqi Wang; Lei Zeng; Amjad Farooq; Ming-Ming Zhou
Structure of the adaptor protein p14 reveals a profilin-like fold with distinct function.
Journal of molecular biology 2005;347(2):309-21.
2004: Chengmin Qian; Lei Zeng; Amjad Farooq; Ming-Ming Zhou
Resonance assignments for the endosomal adaptor protein p14.
Journal of biomolecular NMR 2004;30(3):367-8.
2004: Yong Zhang; Zhiyong Yan; Amjad Farooq; Xiujie Liu; Changlin Lu; Ming-Ming Zhou; Cheng He
Molecular basis of distinct interactions between Dok1 PTB domain and tyrosine-phosphorylated EGF receptor.
Journal of molecular biology 2004;343(4):1147-55.
2004: Amjad Farooq; Ming-Ming Zhou
PTB or not to be: promiscuous, tolerant and Bizarro domains come of age.
IUBMB life 2004;56(9):547-57.
2004: Amjad Farooq; Ming-Ming Zhou
Structure and regulation of MAPK phosphatases.
Cellular signalling 2004;16(7):769-79.
2004: Alexander W Koch; Amjad Farooq; Weisong Shan; Lei Zeng; David R Colman; Ming-Ming Zhou
Structure of the neural (N-) cadherin prodomain reveals a cadherin extracellular domain-like fold without adhesive characteristics.
Structure (London, England : 1993) 2004;12(5):793-805.
2004: Alexander W Koch; Amjad Farooq; Lei Zeng; David R Colman; Ming-Ming Zhou
1H, 13C and 15N resonance assignments for the N-cadherin prodomain.
Journal of biomolecular NMR 2004;28(1):87-8.
2003: Kelley S Yan; Sherry Yan; Amjad Farooq; Arnold Han; Lei Zeng; Ming-Ming Zhou
Structure and conserved RNA binding of the PAZ domain.
Nature 2003;426(6965):468-74.
2003: Amjad Farooq; Lei Zeng; Kelley S Yan; Kodi S Ravichandran; Ming-Ming Zhou
Coupling of folding and binding in the PTB domain of the signaling protein Shc.
Structure (London, England : 1993) 2003;11(8):905-13.
2003: Karishma L Manzur; Amjad Farooq; Lei Zeng; Ming-Ming Zhou
1H, 13C and 15N resonance assignments of a viral SET domain histone lysine methyltransferase.
Journal of biomolecular NMR 2003;26(3):279-80.
2003: Amjad Farooq; Lei Zeng; Ming-Ming Zhou
1H, 15N and 13C resonance assignments for the PTB domain of the signaling protein Shc.
Journal of biomolecular NMR 2003;25(3):255-6.
2003: Karishma L Manzur; Amjad Farooq; Lei Zeng; Olga Plotnikova; Alexander W Koch; Ming-Ming Zhou
A dimeric viral SET domain methyltransferase specific to Lys27 of histone H3.
Nature structural biology 2003;10(3):187-96.
2003: Amjad Farooq; Olga Plotnikova; Gaurav Chaturvedi; Sherry Yan; Lei Zeng; Qiang Zhang; Ming-Ming Zhou
Solution structure of the MAPK phosphatase PAC-1 catalytic domain. Insights into substrate-induced enzymatic activation of MKP.
Structure (London, England : 1993) 2003;11(2):155-64.
2003: Gaurav Chaturvedi; Amjad Farooq; Lei Zeng; Ming-Ming Zhou
1H, 13C and 15N resonance assignments of the catalytic domain of human MAPK phosphatase, PAC-1.
Journal of biomolecular NMR 2003;25(1):79-80.
2002: Kelley S Yan; Miklos Kuti; Sherry Yan; Shiraz Mujtaba; Amjad Farooq; mitchell goldfarb; Ming-Ming Zhou
FRS2 PTB domain conformation regulates interactions with divergent neurotrophic receptors.
The Journal of biological chemistry 2002;277(19):17088-94.
2002: Shiraz Mujtaba; Yan He; Lei Zeng; Amjad Farooq; Justin E Carlson; Melanie Ott; Eric Verdin; Ming-Ming Zhou
Structural basis of lysine-acetylated HIV-1 Tat recognition by PCAF bromodomain.
Molecular cell 2002;9(3):575-86.
2001: Amjad Farooq; L Zeng; Ming-Ming Zhou
1H, 13C and 15N resonance assignments of the ERK2 binding domain of the MAPK phosphatase MKP-3.
Journal of biomolecular NMR 2001;19(2):195-6.
2001: Amjad Farooq; Gaurav Chaturvedi; Shiraz Mujtaba; Olga Plotnikova; Liyu Zeng; C Dhalluin; R Ashton; Ming-Ming Zhou
Solution structure of ERK2 binding domain of MAPK phosphatase MKP-3: structural insights into MKP-3 activation by ERK2.
Molecular cell 2001;7(2):387-99.
1999: Amjad Farooq; Olga Plotnikova; Liyu Zeng; Ming-Ming Zhou
Phosphotyrosine binding domains of Shc and insulin receptor substrate 1 recognize the NPXpY motif in a thermodynamically distinct manner.
The Journal of biological chemistry 1999;274(10):6114-21.
1998: Amjad Farooq
Kinetic evidence for an obligatory intermediate in the folding of the membrane protein bacteriorhodopsin.
Biochemistry 1998;37(43):15170-6.
1997: Paula J Booth; Amjad Farooq
Intermediates in the assembly of bacteriorhodopsin investigated by time-resolved absorption spectroscopy.
European journal of biochemistry / FEBS 1997;246(3):674-80.
1997: Paula J Booth; M L Riley; S L Flitsch; Richard H Templer; Amjad Farooq; A Rachael Curran; N Chadborn; P Wright
Evidence that bilayer bending rigidity affects membrane protein folding.
Biochemistry 1997;36(1):197-203.
1996: Paula J Booth; Amjad Farooq; Sabine L Flitsch
Retinal binding during folding and assembly of the membrane protein bacteriorhodopsin.
Biochemistry 1996;35(18):5902-9.