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Sadaf Farooqi

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Victoria C Cambridge; Samuel R Chamberlain; Chris Dodds; I Sadaf Farooqi; Annelize Koch; Kay Maltby; Antonella Napolitano; Pradeep J Nathan; Andrew L Skeggs; Naresh Subramaniam; Hisham Ziauddeen; Edward T Bullmore; Paul C Fletcher
Neural and behavioral effects of a novel mu opioid receptor antagonist in binge-eating obese people.
Eleanor Wheeler; Inês Barroso; Hannah Blackburn; Elena G Bochukova; Sumedha Garg; Elana Henning; Ni Huang; Matthew E Hurles; Julia M Keogh; Sarah Lindsay; Ruth J F Loos; Stephen O'Rahilly; Nick J Wareham; I Sadaf Farooqi
Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity.
Agatha A van der Klaauw; Anthea Blackwood; Andrea M Haqq; Elana Henning; Julia M Keogh; Jonathan Q Purnell; I Sadaf Farooqi
Postprandial total ghrelin suppression is modulated by melanocortin signaling in humans.

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2013: Victoria C Cambridge; Samuel R Chamberlain; Chris Dodds; I Sadaf Farooqi; Annelize Koch; Kay Maltby; Antonella Napolitano; Pradeep J Nathan; Andrew L Skeggs; Naresh Subramaniam; Hisham Ziauddeen; Edward T Bullmore; Paul C Fletcher
Neural and behavioral effects of a novel mu opioid receptor antagonist in binge-eating obese people.
Biological psychiatry 2013;73(9):887-94.
2013: Eleanor Wheeler; Inês Barroso; Hannah Blackburn; Elena G Bochukova; Sumedha Garg; Elana Henning; Ni Huang; Matthew E Hurles; Julia M Keogh; Sarah Lindsay; Ruth J F Loos; Stephen O'Rahilly; Nick J Wareham; I Sadaf Farooqi
Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity.
Nature genetics 2013;45(5):513-7.
2013: Agatha A van der Klaauw; Anthea Blackwood; Andrea M Haqq; Elana Henning; Julia M Keogh; Jonathan Q Purnell; I Sadaf Farooqi
Postprandial total ghrelin suppression is modulated by melanocortin signaling in humans.
The Journal of clinical endocrinology and metabolism 2013;98(2):E288-92.
2013: Abhishek Nag; David L Pauls; Vincent Plagnol; Victor I Reus; Isabel C Rivas; Roxana Romero; Jeremiah M Scharf; Ana V Valencia-Duarte; Kai Wang; Dongmei Yu; Gabriel Bedoya; Elena G Bochukova; Desmond D Campbell; Julio Cardona; Ed Cook; William Cornejo; M Cuartas; I Sadaf Farooqi; Eduardo Fournier; Nelson B Freimer; Jharley Garcia; Luis D Herrera; Barbara Kremeyer; Thomas L Lowe; Carol A Mathews; Lauren M McGrath; Sandra C Mesa; Heike Muller; Andres Ruiz-Linares
CNV analysis in Tourette syndrome implicates large genomic rearrangements in COL8A1 and NRXN1.
PloS one 2013;8(3):e59061.
2012: Michael E Doche; Lawrence S Argetsinger; Inês Barroso; Elena G Bochukova; Christin Carter-Su; Tim Cheetham; Joel M Cline; Anne Dale; Elana Henning; Julia M Keogh; Stephen O'Rahilly; Laura R Pearce; Liangyou Rui; Hsiao-Wen Su; Sadia Saeed; I Sadaf Farooqi
Human SH2B1 mutations are associated with maladaptive behaviors and obesity.
The Journal of clinical investigation 2012;122(12):4732-6.
2012: Ida J Hatoum; Kasia Blaszczyk; Kelli L Boyd; Roger D Cone; Kate L J Ellacott; I Sadaf Farooqi; Julia M Keogh; Lian Li Ma; Nicholas Stylopoulos; Amanda M Vanhoose; Deng-Ping Yin; Lee M Kaplan
Melanocortin-4 receptor signaling is required for weight loss after gastric bypass surgery.
The Journal of clinical endocrinology and metabolism 2012;97(6):E1023-31.
2012: Hisham Ziauddeen; I Sadaf Farooqi; Paul C Fletcher
Obesity and the brain: how convincing is the addiction model?
Nature reviews. Neuroscience 2012;13(4):279-86.
2012: Elena G Bochukova; Maura Agostini; Assunta Albanese; Murray Bain; Mehul Dattani; Kate Downes; I Sadaf Farooqi; Evelien Gevers; Mark Gurnell; David Halsall; Elana Henning; Julia M Keogh; Faraneh Vargha Khadem; Keith Lindley; Francesco Muntoni; Amaka C Offiah; Odelia Rajanayagam; Jana Reinemund; Margarita Sarri; Erik Schoenmakers; Nadia Schoenmakers; John W R Schwabe; Faraneh Vargha-Khadem; Krishna Chatterjee
A mutation in the thyroid hormone receptor alpha gene.
The New England journal of medicine 2012;366(3):243-9.
2011: Mark J McCabe; Nelly Pitteloud; Eduardo Puelles; Jamal Raza; Massimo Signore; Pei-San Tsai; Vaitsa Tziaferi; Joanna Walker; I Sadaf Farooqi; Carles Gaston-Massuet; Dianne Gerrelli; Louise C Gregory; Scott I Kavanaugh; Juan Pedro Martinez-Barbera; Kyriaki S Alatzoglou; Mehul T Dattani
Novel FGF8 mutations associated with recessive holoprosencephaly, craniofacial defects, and hypothalamo-pituitary dysfunction.
The Journal of clinical endocrinology and metabolism 2011;96(10):E1709-18.
2011: Shwetha Ramachandrappa; I Sadaf Farooqi
Genetic approaches to understanding human obesity.
The Journal of clinical investigation 2011;121(6):2080-6.
2011: I Sadaf Farooqi
Genetic, molecular and physiological insights into human obesity.
European journal of clinical investigation 2011;41(4):451-5.
2011: I Sadaf Farooqi
FTO and obesity: the missing link.
Cell metabolism 2011;13(1):7-8.
2011: Carlos E Martinelli; Julia M Keogh; Jerry R Greenfield; Elana Henning; Agatha A van der Klaauw; Anthea Blackwood; Stephen O'Rahilly; Ferdinand Roelfsema; Cecilia Camacho-Hübner; Hanno Pijl; I Sadaf Farooqi
Obesity due to melanocortin 4 receptor (MC4R) deficiency is associated with increased linear growth and final height, fasting hyperinsulinemia, and incompletely suppressed growth hormone secretion.
The Journal of clinical endocrinology and metabolism 2011;96(1):E181-8.
2010: Patricia René; Christian Le Gouill; Irina D Pogozheva; Gary Lee; Henry I Mosberg; I Sadaf Farooqi; Kenneth J Valenzano; Michel Bouvier
Pharmacological chaperones restore function to MC4R mutants responsible for severe early-onset obesity.
The Journal of pharmacology and experimental therapeutics 2010;335(3):520-32.
2010: Paul C Fletcher; Antonella Napolitano; Andrew Skeggs; Sam R Miller; Bruno Delafont; Victoria C Cambridge; Sanne de Wit; Pradeep J Nathan; Allison Brooke; Stephen O'Rahilly; I Sadaf Farooqi; Edward T Bullmore
Distinct modulatory effects of satiety and sibutramine on brain responses to food images in humans: a double dissociation across hypothalamus, amygdala, and ventral striatum.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(43):14346-55.
2010: Johannes Tschöp; Rubén Nogueiras; Sarah Haas-Lockie; Kevin R Kasten; Tamara R Castañeda; Nadine Huber; Kelsey Guanciale; Diego Perez-Tilve; Kirk Michael Habegger; Nickki Ottaway; Stephen C Woods; Brian Oldfield; Iain Clarke; Streamson Chua Jr.; I Sadaf Farooqi; Stephen O'Rahilly; Charles C Caldwell; Matthias H Tschöp
CNS leptin action modulates immune response and survival in sepsis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(17):6036-47.
2010: Catherine S Mitchell; David B Savage; Sylvie Dufour; Nadia Schoenmakers; Peter Murgatroyd; Douglas Befroy; David Halsall; Samantha Northcott; Philippa Raymond-Barker; Suzanne Curran; Elana Henning; Julia Keogh; Penny Owen; John Lazarus; Douglas L Rothman; I Sadaf Farooqi; Gerald I Shulman; Krishna Chatterjee; Kitt Falk Petersen
Resistance to thyroid hormone is associated with raised energy expenditure, muscle mitochondrial uncoupling, and hyperphagia.
The Journal of clinical investigation 2010;120(4):1345-54.
2010: Elena G Bochukova; Ni Huang; Julia Keogh; Elana Henning; Carolin Purmann; Kasia Blaszczyk; Sadia Saeed; Julian Hamilton-Shield; Jill Clayton-Smith; Stephen O'Rahilly; Matthew E Hurles; I Sadaf Farooqi
Large, rare chromosomal deletions associated with severe early-onset obesity.
Nature 2010;463(7281):666-70.
2010: Kristina Hedbacker; kivanc birsoy; Robert W Wysocki; Esra Asilmaz; Rexford S Ahima; I Sadaf Farooqi; Jeffrey M Friedman
Antidiabetic effects of IGFBP2, a leptin-regulated gene.
Cell metabolism 2010;11(1):11-22.
2010: David Meyre; Karine Proulx; Hiroko Kawagoe-Takaki; Vincent Vatin; Ruth Gutiérrez-Aguilar; Debbie Lyon; Marcella Ma; Hélène Choquet; Fritz F Horber; Wim Van Hul; Luc Van Gaal; Beverley Balkau; Sophie Visvikis-Siest; François Pattou; I Sadaf Farooqi; Vladimir Saudek; Stephen O'Rahilly; philippe froguel; Barbara Sedgwick; Giles S H Yeo
Prevalence of loss-of-function FTO mutations in lean and obese individuals.
Diabetes 2010;59(1):311-8.
2009: Adam J de Smith; Carolin Purmann; Robin G Walters; Richard J Ellis; Susan E Holder; Mieke M van Haelst; Angela F Brady; Una L Fairbrother; Mehul Dattani; Julia M Keogh; Elana Henning; Giles S H Yeo; Stephen O'Rahilly; philippe froguel; I Sadaf Farooqi; Alexandra I F Blakemore
A deletion of the HBII-85 class of small nucleolar RNAs (snoRNAs) is associated with hyperphagia, obesity and hypogonadism.
Human molecular genetics 2009;18(17):3257-65.
2009: Sarah Boissel; Orit Reish; Karine Proulx; Hiroko Kawagoe-Takaki; Barbara Sedgwick; Giles S H Yeo; David Meyre; Christelle Golzio; Florence Molinari; Noman Kadhom; Heather C Etchevers; Vladimir Saudek; I Sadaf Farooqi; philippe froguel; Tomas Lindahl; Stephen O'Rahilly; Arnold Munnich; Laurence Colleaux
Loss-of-function mutation in the dioxygenase-encoding FTO gene causes severe growth retardation and multiple malformations.
American journal of human genetics 2009;85(1):106-11.
2009: I Sadaf Farooqi; Stephen O'Rahilly
Leptin: a pivotal regulator of human energy homeostasis.
The American journal of clinical nutrition 2009;89(3):980S-984S.
2009: Jerry R Greenfield; Jeffrey W Miller; Julia M Keogh; Elana Henning; Julie H Satterwhite; Gregory S Cameron; Beatrice Astruc; John P Mayer; Soren Brage; Teik Choon See; David J Lomas; Stephen O'Rahilly; I Sadaf Farooqi
Modulation of blood pressure by central melanocortinergic pathways.
The New England journal of medicine 2009;360(1):44-52.
2009: Jerry R Greenfield; I Sadaf Farooqi; Julia M Keogh; Elana Henning; Abdella M Habib; Anthea Blackwood; Frank Reimann; Jens J Holst; Fiona M Gribble
Oral glutamine increases circulating glucagon-like peptide 1, glucagon, and insulin concentrations in lean, obese, and type 2 diabetic subjects.
The American journal of clinical nutrition 2009;89(1):106-13.
2009: Karen Tan; Irina D Pogozheva; Giles S H Yeo; Dirk Hadaschik; Julia M Keogh; Carrie Haskell-Leuvano; Stephen O'Rahilly; Henry I Mosberg; I Sadaf Farooqi
Functional characterization and structural modeling of obesity associated mutations in the melanocortin 4 receptor.
Endocrinology 2009;150(1):114-25.
2008: Stephen O'Rahilly; I Sadaf Farooqi
Human obesity as a heritable disorder of the central control of energy balance.
International journal of obesity (2005) 2008;32 Suppl 7():S55-61.
2008: Wendy Kimber; Frank Peelman; Xavier Prieur; Teresia Wangensteen; Stephen O'Rahilly; Jan Tavernier; I Sadaf Farooqi
Functional characterization of naturally occurring pathogenic mutations in the human leptin receptor.
Endocrinology 2008;149(12):6043-52.
2008: Stephen O'Rahilly; I Sadaf Farooqi
Human obesity: a heritable neurobehavioral disorder that is highly sensitive to environmental conditions.
Diabetes 2008;57(11):2905-10.
2008: John W M Creemers; Yung Seng Lee; Robert L Oliver; Mithat Bahceci; Alpaslan Tuzcu; Deniz Gokalp; Julia Keogh; Stefan Herber; Anne White; Stephen O'Rahilly; I Sadaf Farooqi
Mutations in the amino-terminal region of proopiomelanocortin (POMC) in patients with early-onset obesity impair POMC sorting to the regulated secretory pathway.
The Journal of clinical endocrinology and metabolism 2008;93(11):4494-9.
2008: Xavier Prieur; Y C Loraine Tung; Julian L Griffin; I Sadaf Farooqi; Stephen O'Rahilly; Anthony P Coll
Leptin regulates peripheral lipid metabolism primarily through central effects on food intake.
Endocrinology 2008;149(11):5432-9.
2008: Anthony P Coll; Giles S H Yeo; I Sadaf Farooqi; Stephen O'Rahilly
SnapShot: the hormonal control of food intake.
Cell 2008;135(3):572.e1-2.
2008: I Sadaf Farooqi; Stephen O'Rahilly
Mutations in ligands and receptors of the leptin-melanocortin pathway that lead to obesity.
Nature clinical practice. Endocrinology & metabolism 2008;4(10):569-77.
2008: Jane Wardle; Susan Carnell; Claire M A Haworth; I Sadaf Farooqi; Stephen O'Rahilly; Robert Plomin
Obesity associated genetic variation in FTO is associated with diminished satiety.
The Journal of clinical endocrinology and metabolism 2008;93(9):3640-3.
2008: Fanny Stutzmann; Karen Tan; Vincent Vatin; Christian Dina; Béatrice Jouret; Jean Tichet; Beverley Balkau; Natascha Potoczna; Fritz Horber; Stephen O'Rahilly; I Sadaf Farooqi; philippe froguel; David Meyre
Prevalence of melanocortin-4 receptor deficiency in Europeans and their age-dependent penetrance in multigenerational pedigrees.
Diabetes 2008;57(9):2511-8.
2008: I Sadaf Farooqi
Monogenic human obesity.
Frontiers of hormone research 2008;36():1-11.
2007: Thomas Gerken; Christophe A Girard; Yi-Chun Loraine Tung; Celia J Webby; Vladimir Saudek; Kirsty S Hewitson; Giles S H Yeo; Michael McDonough; Sharon Cunliffe; Luke A McNeill; Juris Galvanovskis; Patrik Rorsman; Peter Robins; Xavier Prieur; Anthony P Coll; Marcella Ma; Zorica Jovanovic; I Sadaf Farooqi; Barbara Sedgwick; Inês Barroso; Tomas Lindahl; Chris P Ponting; Frances M Ashcroft; Stephen O'Rahilly; Christopher J Schofield
The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase.
Science (New York, N.Y.) 2007;318(5855):1469-72.
2007: Rubén Nogueiras; Petra Wiedmer; Diego Perez-Tilve; Christelle Veyrat-Durebex; Julia M Keogh; Gregory M Sutton; Paul Pfluger; Tamara R Castaneda; Susanne Neschen; Susanna M Hofmann; Philip N Howles; Donald A Morgan; Stephen C Benoit; Ildiko Szanto; Brigitte Schrott; Annette Schürmann; Hans-Georg Joost; Craig Hammond; David Y Hui; Stephen C Woods; Kamal Rahmouni; Andrew A Butler; I Sadaf Farooqi; Stephen O'Rahilly; Françoise Rohner-Jeanrenaud; Matthias H Tschöp
The central melanocortin system directly controls peripheral lipid metabolism.
The Journal of clinical investigation 2007;117(11):3475-88.
2007: I Sadaf Farooqi; Ed Bullmore; Julia Keogh; Jonathan Gillard; Stephen O'Rahilly; Paul C Fletcher
Leptin regulates striatal regions and human eating behavior.
Science (New York, N.Y.) 2007;317(5843):1355.
2007: I Sadaf Farooqi; Karolien Volders; Richard Stanhope; Robert Heuschkel; Anne White; Emma Lank; Julia Keogh; Stephen O'Rahilly; John W M Creemers
Hyperphagia and early-onset obesity due to a novel homozygous missense mutation in prohormone convertase 1/3.
The Journal of clinical endocrinology and metabolism 2007;92(9):3369-73.
2007: Timothy G Quinnell; I Sadaf Farooqi; Ian E Smith; John M Shneerson
Screening the human prepro-orexin gene in a single-centre narcolepsy cohort.
Sleep medicine 2007;8(5):498-502.
2007: Diego Ize-Ludlow; Juliette A Gray; Mark A Sperling; Elizabeth M Berry-Kravis; Jeff M Milunsky; I Sadaf Farooqi; Casey M Rand; Debra E Weese-Mayer
Rapid-onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation presenting in childhood.
Pediatrics 2007;120(1):e179-88.
2007: Anthony P Coll; I Sadaf Farooqi; Stephen O'Rahilly
The hormonal control of food intake.
Cell 2007;129(2):251-62.
2007: C-C C Hung; Jian'an Luan; M Sims; Julia M Keogh; C Hall; Nicholas J Wareham; Stephen O'Rahilly; I Sadaf Farooqi
Studies of the SIM1 gene in relation to human obesity and obesity-related traits.
International journal of obesity (2005) 2007;31(3):429-34.
2007: Juliette Gray; Giles Yeo; C Hung; Julia Keogh; P Clayton; K Banerjee; A McAulay; Stephen O'Rahilly; I Sadaf Farooqi
Functional characterization of human NTRK2 mutations identified in patients with severe early-onset obesity.
International journal of obesity (2005) 2007;31(2):359-64.
2007: I Sadaf Farooqi; Teresia Wangensteen; Stephan Collins; Wendy Kimber; Giuseppe Matarese; Julia M Keogh; Emma Lank; Bill Bottomley; Judith Lopez-Fernandez; Ivan Ferraz-Amaro; Mehul T Dattani; Oya Ercan; Anne Grethe Myhre; Lars Retterstol; Richard Stanhope; Julie A Edge; Sheila McKenzie; Nader Lessan; Maryam Ghodsi; Veronica De Rosa; Francesco Perna; Silvia Fontana; Inês Barroso; DAG UNDLIEN; Stephen O'Rahilly
Clinical and molecular genetic spectrum of congenital deficiency of the leptin receptor.
The New England journal of medicine 2007;356(3):237-47.
2007: Daniel Lam; I Sadaf Farooqi; Lora K Heisler
Melanocortin receptors as targets in the treatment of obesity.
Current topics in medicinal chemistry 2007;7(11):1085-1097.
2007: I Sadaf Farooqi; Stephen O'Rahilly
Is leptin an important physiological regulator of CRP?
Nature medicine 2007;13(1):16-7; author reply 19-21.
2006: I Sadaf Farooqi
Genetic aspects of severe childhood obesity.
Pediatric endocrinology reviews : PER 2006;3 Suppl 4():528-36.
2006: Juliette Gray; Giles S H Yeo; James Cox; Jenny Morton; Anna-Lynne R Adlam; Julia M Keogh; Jack A Yanovski; Areeg El Gharbawy; Joan C Han; Y C Loraine Tung; John R Hodges; F Lucy Raymond; Stephen O'Rahilly; I Sadaf Farooqi
Hyperphagia, severe obesity, impaired cognitive function, and hyperactivity associated with functional loss of one copy of the brain-derived neurotrophic factor (BDNF) gene.
Diabetes 2006;55(12):3366-71.
2006: Guowen Cai; Shelley A Cole; Nancy F Butte; Carlos A Bacino; Vincent P Diego; Karen Tan; Harald HH Goring; Stephen O'Rahilly; I Sadaf Farooqi; Anthony G Comuzzie
A quantitative trait locus on chromosome 18q for physical activity and dietary intake in Hispanic children.
Obesity (Silver Spring, Md.) 2006;14(9):1596-604.
2006: I Sadaf Farooqi; Stenvert L S Drop; Agnes Clements; Julia M Keogh; Joanna Biernacka; Sarah Lowenbein; Benjamin G Challis; Stephen O'Rahilly
Heterozygosity for a POMC-null mutation and increased obesity risk in humans.
Diabetes 2006;55(9):2549-53.
2006: Stephen O'Rahilly; I Sadaf Farooqi
Genetics of obesity.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2006;361(1471):1095-105.
2006: Sumit Bhattacharyya; Jian'an Luan; Benjamin G Challis; Julia Keogh; Montague Carl; John Brennand; John Morten; Sarah Lowenbeim; Suzanne Jenkins; I Sadaf Farooqi; Nicholas J Wareham; Stephen O'Rahilly
Sequence variants in the melatonin-related receptor gene (GPR50) associate with circulating triglyceride and HDL levels.
Journal of lipid research 2006;47(4):761-6.
2006: I Sadaf Farooqi
The severely obese patient--a genetic work-up.
Nature clinical practice. Endocrinology & metabolism 2006;2(3):172-7; quiz following 177.
2006: Yung Seng Lee; Benjamin G Challis; Darren A Thompson; Giles S H Yeo; Julia M Keogh; Michael E Madonna; Vicki Wraight; Matthew Sims; Vincent Vatin; David Meyre; Julian Shield; Christine Burren; Zala Ibrahim; Tim Cheetham; Peter Swift; Anthea Blackwood; Chiao-Chien Connie Hung; Nicholas J Wareham; philippe froguel; Glenn L Millhauser; Stephen O'Rahilly; I Sadaf Farooqi
A POMC variant implicates beta-melanocyte-stimulating hormone in the control of human energy balance.
Cell metabolism 2006;3(2):135-40.
2006: A Kemal Topaloglu; Zhi-Liang Lu; I Sadaf Farooqi; Neslihan O Mungan; Bilgin Yuksel; Stephen O'Rahilly; Robert P Millar
Molecular genetic analysis of normosmic hypogonadotropic hypogonadism in a Turkish population: identification and detailed functional characterization of a novel mutation in the gonadotropin-releasing hormone receptor gene.
Neuroendocrinology 2006;84(5):301-8.
2006: I Sadaf Farooqi
Monogenic human obesity syndromes.
Progress in brain research 2006;153():119-25.
2005: Megan A O'Neill; I Sadaf Farooqi; Rachel Wevrick
Evaluation of Prader-Willi Syndrome gene MAGEL2 in severe childhood-onset obesity.
Obesity research 2005;13(10):1841-2.
2005: I Sadaf Farooqi
Genetic and hereditary aspects of childhood obesity.
Best practice & research. Clinical endocrinology & metabolism 2005;19(3):359-74.
2005: Paul W Franks; Søren Brage; Jian'an Luan; Ulf Ekelund; Mushtaquar Rahman; I Sadaf Farooqi; Ian Halsall; Stephen O'Rahilly; Nicholas J Wareham
Leptin predicts a worsening of the features of the metabolic syndrome independently of obesity.
Obesity research 2005;13(8):1476-84.
2005: Robert K Semple; J C Achermann; J Ellery; I Sadaf Farooqi; Fiona E Karet; Richard Stanhope; Stephen O'Rahilly; Samuel A J R Aparicio
Two novel missense mutations in g protein-coupled receptor 54 in a patient with hypogonadotropic hypogonadism.
The Journal of clinical endocrinology and metabolism 2005;90(3):1849-55.
2005: I Sadaf Farooqi; Stephen O'Rahilly
Monogenic obesity in humans.
Annual review of medicine 2005;56():443-58.
2004: Giles S H Yeo; Chiao-Chien Connie Hung; Justin J Rochford; Julia Keogh; Juliette Gray; Shoba Sivaramakrishnan; Stephen O'Rahilly; I Sadaf Farooqi
A de novo mutation affecting human TrkB associated with severe obesity and developmental delay.
Nature neuroscience 2004;7(11):1187-9.
2004: Sumit Bhattacharyya; Jian'an Luan; I Sadaf Farooqi; Julia Keogh; Montague Carl; John Brennand; Lynn Jorde; Nicholas J Wareham; Stephen O'Rahilly
Studies of the neuromedin U-2 receptor gene in human obesity: evidence for the existence of two ancestral forms of the receptor.
The Journal of endocrinology 2004;183(1):115-20.
2004: William T Gibson; I Sadaf Farooqi; Mary Moreau; Alex M DePaoli; Elizabeth Lawrence; Stephen O'Rahilly; Rebecca A Trussell
Congenital leptin deficiency due to homozygosity for the Delta133G mutation: report of another case and evaluation of response to four years of leptin therapy.
The Journal of clinical endocrinology and metabolism 2004;89(10):4821-6.
2004: Chiao-Chien Connie Hung; Fraser Pirie; Jian'an Luan; Emma Lank; Ayesha Motala; Giles S H Yeo; Julia M Keogh; Nicholas J Wareham; Stephen O'Rahilly; I Sadaf Farooqi
Studies of the peptide YY and neuropeptide Y2 receptor genes in relation to human obesity and obesity-related traits.
Diabetes 2004;53(9):2461-6.
2004: William T Gibson; Barbara J Ebersole; Sumit Bhattacharyya; Peter Clayton; I Sadaf Farooqi; Stuart C Sealfon; Stephen O'Rahilly
Mutational analysis of the serotonin receptor 5HT2c in severe early-onset human obesity.
Canadian journal of physiology and pharmacology 2004;82(6):426-9.
2004: Anthony P Coll; I Sadaf Farooqi; Benjamin G Challis; Giles S H Yeo; Stephen O'Rahilly
Proopiomelanocortin and energy balance: insights from human and murine genetics.
The Journal of clinical endocrinology and metabolism 2004;89(6):2557-62.
2004: William T Gibson; Pavlos Pissios; Daniel Trombly; Jian'an Luan; Julia Keogh; Nicholas J Wareham; Eleftheria Maratos-Flier; Stephen O'Rahilly; I Sadaf Farooqi
Melanin-concentrating hormone receptor mutations and human obesity: functional analysis.
Obesity research 2004;12(5):743-9.
2004: Stephen O'Rahilly; Giles S H Yeo; I Sadaf Farooqi
Melanocortin receptors weigh in.
Nature medicine 2004;10(4):351-2.
2004: Benjamin G Challis; Jian'an Luan; Julia Keogh; Nicholas J Wareham; I Sadaf Farooqi; Stephen O'Rahilly
Genetic variation in the corticotrophin-releasing factor receptors: identification of single-nucleotide polymorphisms and association studies with obesity in UK Caucasians.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2004;28(3):442-6.
2004: I Sadaf Farooqi; Stephen O'Rahilly
Monogenic human obesity syndromes.
Recent progress in hormone research 2004;59():409-24.
2003: Robert S Jackson; John W M Creemers; I Sadaf Farooqi; Marie-Laure Raffin-Sanson; Andrea Varro; Graham J Dockray; Jens J Holst; Patricia L Brubaker; Pierre Corvol; Kenneth S Polonsky; Diane Ostrega; Kenneth L Becker; Xavier Bertagna; John C Hutton; Anne White; Mehul T Dattani; Khalid Hussain; Stephen J Middleton; Thomasina M Nicole; Peter J Milla; Keith J Lindley; Stephen O'Rahilly
Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency.
The Journal of clinical investigation 2003;112(10):1550-60.
2003: Stephen O'Rahilly; I Sadaf Farooqi; Giles S H Yeo; Benjamin G Challis
Minireview: human obesity-lessons from monogenic disorders.
Endocrinology 2003;144(9):3757-64.
2003: Paul W Franks; I Sadaf Farooqi; Jian'an Luan; Man-Yu Wong; Ian Halsall; Stephen O'Rahilly; Nicholas J Wareham
Does physical activity energy expenditure explain the between-individual variation in plasma leptin concentrations after adjusting for differences in body composition?
The Journal of clinical endocrinology and metabolism 2003;88(7):3258-63.
2003: Sumit Bhattacharyya; Jian'an Luan; Benjamin G Challis; Catherine Schmitz; Paul Clarkson; Paul W Franks; Rita P S Middelberg; Julia Keogh; I Sadaf Farooqi; Montague Carl; John Brennand; Nicholas J Wareham; Stephen O'Rahilly
Association of polymorphisms in GPR10, the gene encoding the prolactin-releasing peptide receptor with blood pressure, but not obesity, in a U.K. Caucasian population.
Diabetes 2003;52(5):1296-9.
2003: Chiao-Chien Connie Hung; I Sadaf Farooqi; Ken Ong; Jian'an Luan; Julia M Keogh; Marcus E Pembrey; Giles S H Yeo; David D Dunger; Nicholas J Wareham; Stephen O' Rahilly
Contribution of variants in the small heterodimer partner gene to birthweight, adiposity, and insulin levels: mutational analysis and association studies in multiple populations.
Diabetes 2003;52(5):1288-91.
2003: I Sadaf Farooqi; Julia M Keogh; Giles S H Yeo; Emma Lank; Tim Cheetham; Stephen O'Rahilly
Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene.
The New England journal of medicine 2003;348(12):1085-95.
2003: Giles S H Yeo; Emma Lank; I Sadaf Farooqi; Julia Keogh; Benjamin G Challis; Stephen O'Rahilly
Mutations in the human melanocortin-4 receptor gene associated with severe familial obesity disrupts receptor function through multiple molecular mechanisms.
Human molecular genetics 2003;12(5):561-74.
2003: Andrea M Haqq; I Sadaf Farooqi; Stephen O'Rahilly; Diane D Stadler; Ronald G Rosenfeld; Katherine L Pratt; Stephen H LaFranchi; Jonathan Q Purnell
Serum ghrelin levels are inversely correlated with body mass index, age, and insulin concentrations in normal children and are markedly increased in Prader-Willi syndrome.
The Journal of clinical endocrinology and metabolism 2003;88(1):174-8.
2002: Atul Singhal; I Sadaf Farooqi; Tim J Cole; Stephen O'Rahilly; Mary S Fewtrell; Mia Kattenhorn; Alan Lucas; John Deanfield
Influence of leptin on arterial distensibility: a novel link between obesity and cardiovascular disease?
Circulation 2002;106(15):1919-24.
2002: I Sadaf Farooqi; Giuseppe Matarese; Graham M Lord; Julia M Keogh; Elizabeth Lawrence; J. CHIZO AGWU; Veronica Sanna; Susan A Jebb; Francesco Perna; Silvia Fontana; Robert I Lechler; Alex M DePaoli; Stephen O'Rahilly
Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency.
The Journal of clinical investigation 2002;110(8):1093-103.
2002: Benjamin G Challis; Lynn E Pritchard; John W M Creemers; Jerome Delplanque; Julia M Keogh; Jian'an Luan; Nicholas J Wareham; Giles S H Yeo; Sumit Bhattacharyya; philippe froguel; Anne White; I Sadaf Farooqi; Stephen O'Rahilly
A missense mutation disrupting a dibasic prohormone processing site in pro-opiomelanocortin (POMC) increases susceptibility to early-onset obesity through a novel molecular mechanism.
Human molecular genetics 2002;11(17):1997-2004.
2002: Atul Singhal; I Sadaf Farooqi; Stephen O'Rahilly; Tim J Cole; Mary S Fewtrell; Alan Lucas
Early nutrition and leptin concentrations in later life.
The American journal of clinical nutrition 2002;75(6):993-9.
2002: I Sadaf Farooqi
Leptin and the onset of puberty: insights from rodent and human genetics.
Seminars in reproductive medicine 2002;20(2):139-44.
2001: I Sadaf Farooqi; Julia M Keogh; S Kamath; S Jones; William T Gibson; R Trussell; Susan A Jebb; G Y Lip; Stephen O'Rahilly
Partial leptin deficiency and human adiposity.
Nature 2001;414(6859):34-5.
2001: Halsall David; Jian'an Luan; P Saker; S Huxtable; I Sadaf Farooqi; Julia Keogh; Nicholas J Wareham; Stephen O'Rahilly
Uncoupling protein 3 genetic variants in human obesity: the c-55t promoter polymorphism is negatively correlated with body mass index in a UK Caucasian population.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2001;25(4):472-7.
2000: I Sadaf Farooqi; M K Jones; M Evans; Stephen O'Rahilly; John R Hodges
Triple H syndrome: a novel autoimmune endocrinopathy characterized by dysfunction of the hippocampus, hair follicle, and hypothalamic-pituitary adrenal axis.
The Journal of clinical endocrinology and metabolism 2000;85(8):2644-8.
2000: I Sadaf Farooqi; Giles S H Yeo; Julia M Keogh; S Aminian; Susan A Jebb; G Butler; Tim Cheetham; Stephen O'Rahilly
Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency.
The Journal of clinical investigation 2000;106(2):271-9.
2000: I Sadaf Farooqi; Stephen O'Rahilly
Recent advances in the genetics of severe childhood obesity.
Archives of disease in childhood 2000;83(1):31-4.
2000: Benjamin G Challis; Giles S H Yeo; I Sadaf Farooqi; Jian'an Luan; S Aminian; Halsall David; Julia M Keogh; Nicholas J Wareham; Stephen O'Rahilly
The CART gene and human obesity: mutational analysis and population genetics.
Diabetes 2000;49(5):872-5.
2000: Giles S H Yeo; I Sadaf Farooqi; Benjamin G Challis; Robert S Jackson; Stephen O'Rahilly
The role of melanocortin signalling in the control of body weight: evidence from human and murine genetic models.
QJM : monthly journal of the Association of Physicians 2000;93(1):7-14.
1999: I Sadaf Farooqi; Susan A Jebb; G Langmack; E Lawrence; C H Cheetham; Andrew M Prentice; Ieuan A Hughes; M A McCamish; Stephen O'Rahilly
Effects of recombinant leptin therapy in a child with congenital leptin deficiency.
The New England journal of medicine 1999;341(12):879-84.
1998: Giles S H Yeo; I Sadaf Farooqi; S Aminian; Halsall David; R G Stanhope; Stephen O'Rahilly
A frameshift mutation in MC4R associated with dominantly inherited human obesity.
Nature genetics 1998;20(2):111-2.
1997: Montague Carl; I Sadaf Farooqi; Jonathan P Whitehead; Maria A Soos; H Rau; Nicholas J Wareham; Ciaran Sewter; JE Digby; S N Mohammed; J A Hurst; C H Cheetham; A R Earley; A H Barnett; Johannes B Prins; Stephen O'Rahilly
Congenital leptin deficiency is associated with severe early-onset obesity in humans.
Nature 1997;387(6636):903-8.