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Nicholas Farrell

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Co-Publications
Name
21
Brabec, Viktor
21
Qu, Yun
12
Kasparkova, Jana
11
Skov, Kirsten
9
Hegmans, Alexander
9
Berners-Price, Susan
7
Davies, Murray
7
Van Houten, Bennett
6
Kaspárková, Jana
6
Kelland, Lloyd
5
Cox, John
5
Thomas, Donald
5
Nováková, Olga
5
Anzellotti, Atilio
4
Zunino, Franco

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Publications

TOP 3
Zerzankova Lenka; Suchankova Tereza; Vrana Oldrich; Farrell Nicholas P; Brabec Viktor; Kasparkova Jana
Conformation and recognition of DNA modified by a new antitumor dinuclear PtII complex resistant to decomposition by sulfur nucleophiles.
de Paula Queite A; Mangrum John B; Farrell Nicholas P
Zinc finger proteins as templates for metal ion exchange: Substitution effects on the C-finger of HIV nucleocapsid NCp7 using M(chelate) species (M=Pt, Pd, Au).
Ruhayel Rasha A; Moniodis Joseph J; Yang Xiaohong; Kasparkova Jana; Brabec Viktor; Berners-Price Susan J; Farrell Nicholas P
Factors affecting DNA-DNA interstrand cross-links in the antiparallel 3'-3' sense: a comparison with the 5'-5' directional isomer.

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All Publications

2010: Zerzankova Lenka; Suchankova Tereza; Vrana Oldrich; Farrell Nicholas P; Brabec Viktor; Kasparkova Jana
Conformation and recognition of DNA modified by a new antitumor dinuclear PtII complex resistant to decomposition by sulfur nucleophiles.
Biochemical pharmacology 2010;79(2):112-21.
2009: de Paula Queite A; Mangrum John B; Farrell Nicholas P
Zinc finger proteins as templates for metal ion exchange: Substitution effects on the C-finger of HIV nucleocapsid NCp7 using M(chelate) species (M=Pt, Pd, Au).
Journal of inorganic biochemistry 2009;103(10):1347-54.
2009: Ruhayel Rasha A; Moniodis Joseph J; Yang Xiaohong; Kasparkova Jana; Brabec Viktor; Berners-Price Susan J; Farrell Nicholas P
Factors affecting DNA-DNA interstrand cross-links in the antiparallel 3'-3' sense: a comparison with the 5'-5' directional isomer.
Chemistry (Weinheim an der Bergstrasse, Germany) 2009;15(37):9365-74.
2009: Qu Yun; Tran My-Chau; Farrell Nicholas P
Structural consequences of a 3'-->3' DNA interstrand cross-link by a trinuclear platinum complex: unique formation of two such cross-links in a 10-mer duplex.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2009;14(6):969-77.
2008: Anzellotti Atilio I; Bayse Craig A; Farrell Nicholas P
Effects of nucleobase metalation on frontier molecular orbitals: potential implications for pi-stacking interactions with tryptophan.
Inorganic chemistry 2008;47(22):10425-31.
2008: Anzellotti A I; Farrell N P
Zinc metalloproteins as medicinal targets.
Chemical Society reviews 2008;37(8):1629-51.
2008: Hegmans Alexander; Kasparkova Jana; Vrana Oldrich; Kelland Lloyd R; Brabec Viktor; Farrell Nicholas P
Amide-based prodrugs of spermidine-bridged dinuclear platinum. Synthesis, DNA binding, and biological activity.
Journal of medicinal chemistry 2008;51(7):2254-60.
2008: Zhang Junyong; Thomas Donald S; Berners-Price Susan J; Farrell Nicholas
Effects of geometric isomerism and anions on the kinetics and mechanism of the stepwise formation of long-range DNA interstrand cross-links by dinuclear platinum antitumor complexes.
Chemistry (Weinheim an der Bergstrasse, Germany) 2008;14(21):6391-405.
2007: Montero Eva I; Benedetti Brad T; Mangrum John B; Oehlsen Michael J; Qu Yun; Farrell Nicholas P
Pre-association of polynuclear platinum anticancer agents on a protein, human serum albumin. Implications for drug design.
Dalton transactions (Cambridge, England : 2003) 2007;(43):4938-42.
2007: Mitchell Clint; Kabolizadeh Peyman; Ryan John; Roberts John D; Yacoub Adly; Curiel David T; Fisher Paul B; Hagan Michael P; Farrell Nicholas P; Grant Steven; Dent Paul
Low-dose BBR3610 toxicity in colon cancer cells is p53-independent and enhanced by inhibition of epidermal growth factor receptor (ERBB1)-phosphatidyl inositol 3 kinase signaling.
Molecular pharmacology 2007;72(3):704-14.
2007: Williams John W; Qu Yun; Bulluss Genevieve H; Alvorado Eugenio; Farrell Nicholas P
Dinuclear platinum complexes with biological relevance based on the 1,2-diaminocyclohexane carrier ligand.
Inorganic chemistry 2007;46(15):5820-2.
2007: Aris Sheena M; Gewirtz David A; Ryan John J; Knott Kenneth M; Farrell Nicholas P
Promotion of DNA strand breaks, interstrand cross-links and apoptotic cell death in A2780 human ovarian cancer cells by transplatinum planar amine complexes.
Biochemical pharmacology 2007;73(11):1749-57.
2007: Kabolizadeh Peyman; Ryan John; Farrell Nicholas
Differences in the cellular response and signaling pathways of cisplatin and BBR3464 ([[trans-PtCl(NH3)(2)]2mu-(trans-Pt(NH3)(2)(H2N(CH2)(6)-NH2)2)]4+) influenced by copper homeostasis.
Biochemical pharmacology 2007;73(9):1270-9.
2007: Moriarity Branden; Nováková Olga; Farrell Nicholas; Brabec Viktor; Kaspárková Jana
1,2-GG intrastrand cross-link of antitumor dinuclear bifunctional platinum compound with spermidine linker inhibits DNA polymerization more effectively than the cross-link of conventional cisplatin.
Archives of biochemistry and biophysics 2007;459(2):264-72.
2006: Chválová Katerina; Kaspárková Jana; Farrell Nicholas; Brabec Viktor
Deoxyribonuclease I footprinting reveals different DNA binding modes of bifunctional platinum complexes.
The FEBS journal 2006;273(15):3467-78.
2006: Bulluss Genevieve H; Knott Kenneth M; Ma Erin S F; Aris Sheena M; Alvarado Eugenio; Farrell Nicholas
trans-Platinum planar amine compounds with [N2O2] ligand donor sets: effects of carboxylate leaving groups and steric hindrance on chemical and biological properties.
Inorganic chemistry 2006;45(15):5733-5.
2006: Anzellotti Atilio I; Liu Qin; Bloemink Marieke J; Scarsdale J Neel; Farrell Nicholas
Targeting retroviral Zn finger-DNA interactions: a small-molecule approach using the electrophilic nature of trans-platinum-nucleobase compounds.
Chemistry & biology 2006;13(5):539-48.
2006: Liu Qin; Qu Yun; Van Antwerpen Rik; Farrell Nicholas
Mechanism of the membrane interaction of polynuclear platinum anticancer agents. Implications for cellular uptake.
Biochemistry 2006;45(13):4248-56.
2006: Anzellotti Atilio I; Sabat Michal; Farrell Nicholas
Covalent and noncovalent interactions for [metal(dien)nucleobase](2+) complexes with L-tryptophan derivatives: formation of palladium-tryptophan species by nucleobase substitution under biologically relevant conditions.
Inorganic chemistry 2006;45(4):1638-45.
2006: Harris Amanda L; Ryan John J; Farrell Nicholas
Biological consequences of trinuclear platinum complexes: comparison of [[trans-PtCl(NH3)2]2mu-(trans-Pt(NH3)2(H2N(CH2)6-NH2)2)]4+ (BBR 3464) with its noncovalent congeners.
Molecular pharmacology 2006;69(2):666-72.
2005: Harris Amanda L; Yang Xiaohong; Hegmans Alex; Povirk Lawrence; Ryan John J; Kelland Lloyd; Farrell Nicholas P
Synthesis, characterization, and cytotoxicity of a novel highly charged trinuclear platinum compound. Enhancement of cellular uptake with charge.
Inorganic chemistry 2005;44(26):9598-600.
2005: Zhang Junyong; Thomas Donald S; Davies Murray S; Berners-Price Susan J; Farrell Nicholas
Effects of geometric isomerism in dinuclear platinum antitumor complexes on aquation reactions in the presence of perchlorate, acetate and phosphate.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2005;10(6):652-66.
2005: Ma Erin S F; Bates W Douglas; Edmunds Armistead; Kelland Lloyd R; Fojo Tito; Farrell Nicholas
Enhancement of aqueous solubility and stability employing a trans acetate axis in trans planar amine platinum compounds while maintaining the biological profile.
Journal of medicinal chemistry 2005;48(18):5651-4.
2005: Liu Qin; Golden Melissa; Darensbourg Marcetta Y; Farrell Nicholas
Thiolate-bridged heterodinuclear platinum-zinc chelates as models for ternary platinum-DNA-protein complexes and zinc ejection from zinc fingers. Evidence from studies using ESI-mass spectrometry.
Chemical communications (Cambridge, England) 2005;(34):4360-2.
2005: Oehlsen Michael E; Hegmans Alexander; Qu Yun; Farrell Nicholas
Effects of geometric isomerism in dinuclear antitumor platinum complexes on their interactions with N-acetyl-L-methionine.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2005;10(5):433-42.
2005: Oehlsen Michael E; Hegmans Alexander; Qu Yun; Farrell Nicholas
A surprisingly stable macrochelate formed from the reaction of cis dinuclear platinum antitumor compounds with reduced glutathione.
Inorganic chemistry 2005;44(9):3004-6.
2005: Harris Amanda; Qu Yun; Farrell Nicholas
Unique cooperative binding interaction observed between a minor groove binding Pt antitumor agent and Hoechst dye 33258.
Inorganic chemistry 2005;44(5):1196-8.
2005: Anzellotti Atilio I; Ma Erin S; Farrell Nicholas
Platination of nucleobases to enhance noncovalent recognition in protein-DNA/RNA complexes.
Inorganic chemistry 2005;44(3):483-5.
2005: Marini Victoria; Christofis Petros; Novakova Olga; Kasparkova Jana; Farrell Nicholas; Brabec Viktor
Conformation, protein recognition and repair of DNA interstrand and intrastrand cross-links of antitumor trans-[PtCl2(NH3)(thiazole)].
Nucleic acids research 2005;33(18):5819-28.
2004: Farrell Nicholas P
Preclinical perspectives on the use of platinum compounds in cancer chemotherapy.
Seminars in oncology 2004;31(6 Suppl 14):1-9.
2004: Qu Yun; Harris Amanda; Hegmans Alexander; Petz Andrea; Kabolizadeh Peyman; Penazova Hana; Farrell Nicholas
Synthesis and DNA conformational changes of non-covalent polynuclear platinum complexes.
Journal of inorganic biochemistry 2004;98(10):1591-8.
2004: Qu Yun; Scarsdale Neel J; Tran My-Chau; Farrell Nicholas
Comparison of structural effects in 1,4 DNA-DNA interstrand cross-links formed by dinuclear and trinuclear platinum complexes.
Journal of inorganic biochemistry 2004;98(10):1585-90.
2004: Kasparkova Jana; Vrana Oldrich; Farrell Nicholas; Brabec Viktor
Effect of the geometry of the central coordination sphere in antitumor trinuclear platinum complexes on DNA binding.
Journal of inorganic biochemistry 2004;98(10):1560-9.
2004: Farrell Nicholas; Povirk Lawrence F; Dange Yojana; DeMasters Gerald; Gupta Mona S; Kohlhagen Glenda; Khan Qasim A; Pommier Yves; Gewirtz David A
Cytotoxicity, DNA strand breakage and DNA-protein crosslinking by a novel transplatinum compound in human A2780 ovarian and MCF-7 breast carcinoma cells.
Biochemical pharmacology 2004;68(5):857-66.
2004: Kloster Miriam; Kostrhunova Hana; Zaludova Renata; Malina Jaroslav; Kasparkova Jana; Brabec Viktor; Farrell Nicholas
Trifunctional dinuclear platinum complexes as DNA-protein cross-linking agents.
Biochemistry 2004;43(24):7776-86.
2004: Hegmans Alexander; Berners-Price Susan J; Davies Murray S; Thomas Donald S; Humphreys Anthony S; Farrell Nicholas
Long range 1,4 and 1,6-interstrand cross-links formed by a trinuclear platinum complex. Minor groove preassociation affects kinetics and mechanism of cross-link formation as well as adduct structure.
Journal of the American Chemical Society 2004;126(7):2166-80.
2004: Kasparkova Jana; Fojta Miroslav; Farrell Nicholas; Brabec Viktor
Differential recognition by the tumor suppressor protein p53 of DNA modified by the novel antitumor trinuclear platinum drug BBR3464 and cisplatin.
Nucleic acids research 2004;32(18):5546-52.
2004: Farrell Nicholas
Polynuclear platinum drugs.
Metal ions in biological systems 2004;42():251-96.
2003: Oehlsen Michael E; Qu Yun; Farrell Nicholas
Reaction of polynuclear platinum antitumor compounds with reduced glutathione studied by multinuclear (1H, 1H-15N gradient heteronuclear single-quantum coherence, and 195Pt) NMR spectroscopy.
Inorganic chemistry 2003;42(18):5498-506.
2003: Berners-Price Susan J; Davies Murray S; Cox John W; Thomas Donald S; Farrell Nicholas
Competitive reactions of interstrand and intrastrand DNA-Pt adducts: A dinuclear-platinum complex preferentially forms a 1,4-interstrand cross-link rather than a 1,2 intrastrand cross-link on binding to a GG 14-mer duplex.
Chemistry (Weinheim an der Bergstrasse, Germany) 2003;9(3):713-25.
2003: Davies Murray S; Berners-Price Susan J; Cox John W; Farrell Nicholas
The nature of the DNA template (single- versus double-stranded) affects the rate of aquation of a dinuclear Pt anticancer drug.
Chemical communications (Cambridge, England) 2003;(1):122-3.
2003: Kasparkova Jana; Novakova Olga; Farrell Nicholas; Brabec Viktor
DNA binding by antitumor trans-[PtCl2(NH3)(thiazole)]. Protein recognition and nucleotide excision repair of monofunctional adducts.
Biochemistry 2003;42(3):792-800.
2003: Qu Yun; Scarsdale Neel J; Tran My-Chau; Farrell Nicholas P
Cooperative effects in long-range 1,4 DNA-DNA interstrand cross-links formed by polynuclear platinum complexes: an unexpected syn orientation of adenine bases outside the binding sites.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2003;8(1-2):19-28.
2002: Kasparkova Jana; Zehnulova Jana; Farrell Nicholas; Brabec Viktor
DNA interstrand cross-links of the novel antitumor trinuclear platinum complex BBR3464. Conformation, recognition by high mobility group domain proteins, and nucleotide excision repair.
The Journal of biological chemistry 2002;277(50):48076-86.
2002: McGregor Tracey D; Bousfield Wendi; Qu Yun; Farrell Nicholas
Circular dichroism study of the irreversibility of conformational changes induced by polyamine-linked dinuclear platinum compounds.
Journal of inorganic biochemistry 2002;91(1):212-9.
2002: McGregor Tracey D; Hegmans Alexander; Kaspárková Jana; Neplechová Kamila; Nováková Olga; Penazová Hana; Vrána Oldrich; Brabec Viktor; Farrell Nicholas
A comparison of DNA binding profiles of dinuclear platinum compounds with polyamine linkers and the trinuclear platinum phase II clinical agent BBR3464.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2002;7(4-5):397-404.
2002: Davies Murray S; Thomas Donald S; Hegmans Alexander; Berners-Price Susan J; Farrell Nicholas
Kinetic and equilibria studies of the aquation of the trinuclear platinum phase II anticancer agent [(trans-PtCl(NH(3))(2))(2)(mu-trans-Pt(NH(3))(2)(NH(2)(CH(2))(6)NH(2))(2))](4+) (BBR3464).
Inorganic chemistry 2002;41(5):1101-9.
2001: Qu Y; Fitzgerald J A; Rauter H; Farrell N
Approaches to selective DNA binding in polyfunctional dinuclear platinum chemistry. The synthesis of a trifunctional compound and its interaction with the mononucleotide 5'-guanosine monophosphate.
Inorganic chemistry 2001;40(24):6324-7.
2001: Hegmans A; Qu Y; Kelland L R; Roberts J D; Farrell N
Novel approaches to polynuclear platinum pro-drugs. Selective release of cytotoxic platinum-spermidine species through hydrolytic cleavage of carbamates.
Inorganic chemistry 2001;40(24):6108-14.
2001: Zehnulova J; Kasparkova J; Farrell N; Brabec V
Conformation, recognition by high mobility group domain proteins, and nucleotide excision repair of DNA intrastrand cross-links of novel antitumor trinuclear platinum complex BBR3464.
The Journal of biological chemistry 2001;276(25):22191-9.
2001: Hofr C; Farrell N; Brabec V
Thermodynamic properties of duplex DNA containing a site-specific d(GpG) intrastrand crosslink formed by an antitumor dinuclear platinum complex.
Nucleic acids research 2001;29(10):2034-40.
2001: Cox J W; Berners-Price S J; Davies M S; Qu Y; Farrell N
Kinetic analysis of the stepwise formation of a long-range DNA interstrand cross-link by a dinuclear platinum antitumor complex: evidence for aquated intermediates and formation of both kinetically and thermodynamically controlled conformers.
Journal of the American Chemical Society 2001;123(7):1316-26.
2000: Sartori D A; Miller B; Biebach U; Farrell N
Modulation of the chemical and biological properties of trans platinum complexes: monofunctional platinum complexes containing one nucleobase as potential antiviral chemotypes.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2000;5(5):575-83.
2000: Qu Y; Rauter H; Soares Fontes A P; Bandarage R; Kelland L R; Farrell N
Synthesis, characterization, and cytotoxicity of trifunctional dinuclear platinum complexes: comparison of effects of geometry and polyfunctionality on biological activity.
Journal of medicinal chemistry 2000;43(16):3189-92.
2000: Manzotti C; Pratesi G; Menta E; Di Domenico R; Cavalletti E; Fiebig H H; Kelland L R; Farrell N; Polizzi D; Supino R; Pezzoni G; Zunino F
BBR 3464: a novel triplatinum complex, exhibiting a preclinical profile of antitumor efficacy different from cisplatin.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(7):2626-34.
2000: Brabec V; Neplechova K; Kasparkova J; Farrell N
Steric control of DNA interstrand cross-link sites of trans platinum complexes: specificity can be dictated by planar nonleaving groups.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2000;5(3):364-8.
2000: Bierbach U; Sabat M; Farrell N
Inversion of the cis geometry requirement for cytotoxicity in structurally novel platinum(II) complexes containing the bidentate N,O-donor pyridin-2-yl-acetate.
Inorganic chemistry 2000;39(9):1882-90.
2000: Kasparkova J; Farrell N; Brabec V
Sequence specificity, conformation, and recognition by HMG1 protein of major DNA interstrand cross-links of antitumor dinuclear platinum complexes.
The Journal of biological chemistry 2000;275(21):15789-98.
2000: Davies M S; Cox J W; Berners-Price S J; Barklage W; Qu Y; Farrell N
Equilibrium and kinetic studies of the aquation of the dinuclear platinum complex [[trans-PtCl(NH3)2]2(mu-NH2(CH2)6NH2)]2+: pKa determinations of aqua ligands via [1H,15N] NMR spectroscopy.
Inorganic chemistry 2000;39(8):1710-5.
1999: Kloster M B; Hannis J C; Muddiman D C; Farrell N
Consequences of nucleic acid conformation on the binding of a trinuclear platinum drug.
Biochemistry 1999;38(45):14731-7.
1999: Perego P; Gatti L; Caserini C; Supino R; Colangelo D; Leone R; Spinelli S; Farrell N; Zunino F
The cellular basis of the efficacy of the trinuclear platinum complex BBR 3464 against cisplatin-resistant cells.
Journal of inorganic biochemistry 1999;77(1-2):59-64.
1999: Roberts J D; Peroutka J; Farrell N
Cellular pharmacology of polynuclear platinum anti-cancer agents.
Journal of inorganic biochemistry 1999;77(1-2):51-7.
1999: Roberts J D; Peroutka J; Beggiolin G; Manzotti C; Piazzoni L; Farrell N
Comparison of cytotoxicity and cellular accumulation of polynuclear platinum complexes in L1210 murine leukemia cell lines.
Journal of inorganic biochemistry 1999;77(1-2):47-50.
1999: McGregor T D; Balcarová Z; Qu Y; Tran M C; Zaludová R; Brabec V; Farrell N
Sequence-dependent conformational changes in DNA induced by polynuclear platinum complexes.
Journal of inorganic biochemistry 1999;77(1-2):43-6.
1999: Pratesi G; Perego P; Polizzi D; Righetti S C; Supino R; Caserini C; Manzotti C; Giuliani F C; Pezzoni G; Tognella S; Spinelli S; Farrell N; Zunino F
A novel charged trinuclear platinum complex effective against cisplatin-resistant tumours: hypersensitivity of p53-mutant human tumour xenografts.
British journal of cancer 1999;80(12):1912-9.
1999: Kaspárková J; Nováková O; Vrána O; Farrell N; Brabec V
Effect of geometric isomerism in dinuclear platinum antitumor complexes on DNA interstrand cross-linking.
Biochemistry 1999;38(34):10997-1005.
1999: Brabec V; Kaspárková J; Vrána O; Nováková O; Cox J W; Qu Y; Farrell N
DNA modifications by a novel bifunctional trinuclear platinum phase I anticancer agent.
Biochemistry 1999;38(21):6781-90.
1999: Perego P; Caserini C; Gatti L; Carenini N; Romanelli S; Supino R; Colangelo D; Viano I; Leone R; Spinelli S; Pezzoni G; Manzotti C; Farrell N; Zunino F
A novel trinuclear platinum complex overcomes cisplatin resistance in an osteosarcoma cell system.
Molecular pharmacology 1999;55(3):528-34.
1998: Zákovská A; Nováková O; Balcarová Z; Bierbach U; Farrell N; Brabec V
DNA interactions of antitumor trans-[PtCl2(NH3)(quinoline)].
European journal of biochemistry / FEBS 1998;254(3):547-57.
1998: Schaaff T G; Qu Y; Farrell N; Wysocki V H
Investigation of the trans effect in the fragmentation of dinuclear platinum complexes by electrospray ionization surface-induced dissociation tandem mass spectrometry.
Journal of mass spectrometry : JMS 1998;33(5):436-43.
1997: Zaludová R; Zákovská A; Kasparková J; Balcarová Z; Kleinwächter V; Vrána O; Farrell N; Brabec V
DNA interactions of bifunctional dinuclear platinum(II) antitumor agents.
European journal of biochemistry / FEBS 1997;246(2):508-17.
1997: Mellish K J; Qu Y; Scarsdale N; Farrell N
Effect of geometric isomerism in dinuclear platinum antitumour complexes on the rate of formation and structure of intrastrand adducts with oligonucleotides.
Nucleic acids research 1997;25(6):1265-71.
1996: Kaspárková J; Mellish K J; Qu Y; Brabec V; Farrell N
Site-specific d(GpG) intrastrand cross-links formed by dinuclear platinum complexes. Bending and NMR studies.
Biochemistry 1996;35(51):16705-13.
1996: Matthews J; Adomat H; Farrell N; King P; Koch C; Lord E; Palcic B; Poulin N; Sangulin J; Skov K
Immunocytochemical labelling of aerobic and hypoxic mammalian cells using a platinated derivative of EF5.
The British journal of cancer. Supplement 1996;27():S200-3.
1996: Wu P K; Kharatishvili M; Qu Y; Farrell N
A circular dichroism study of ethidium bromide binding to Z-DNA induced by dinuclear platinum complexes.
Journal of inorganic biochemistry 1996;63(1):9-18.
1996: Farrell N
Current status of structure-activity relationships of platinum anticancer drugs: activation of the trans geometry.
Metal ions in biological systems 1996;32():603-39.
1995: Farrell N; Appleton T G; Qu Y; Roberts J D; Fontes A P; Skov K A; Wu P; Zou Y
Effects of geometric isomerism and ligand substitution in bifunctional dinuclear platinum complexes on binding properties and conformational changes in DNA.
Biochemistry 1995;34(47):15480-6.
1995: Bernareggi A; Torti L; Facino R M; Carini M; Depta G; Casetta B; Farrell N; Spadacini S; Ceserani R; Tognella S
Characterization of cisplatin-glutathione adducts by liquid chromatography-mass spectrometry. Evidence for their formation in vitro but not in vivo after concomitant administration of cisplatin and glutathione to rats anc cancer patients.
Journal of chromatography. B, Biomedical applications 1995;669(2):247-63.
1994: Marples B; Adomat H; Billings P C; Farrell N P; Koch C J; Skov K A
Recognition of platinum-induced DNA damage by nuclear proteins: screening for mechanisms.
Anti-cancer drug design 1994;9(5):389-99.
1994: Zou Y; Van Houten B; Farrell N
Sequence specificity of DNA-DNA interstrand cross-link formation by cisplatin and dinuclear platinum complexes.
Biochemistry 1994;33(18):5404-10.
1994: Wu P K; Qu Y; Van Houten B; Farrell N
Chemical reactivity and DNA sequence specificity of formally monofunctional and bifunctional bis(platinum) complexes.
Journal of inorganic biochemistry 1994;54(3):207-20.
1994: Skov K A; Adomat H; Doedee M; Farrell N
Radiosensitizing and toxic properties of quinoline and nitroquinoline complexes of platinum [PtCl2(NH3)quinoline].
Anti-cancer drug design 1994;9(2):103-17.
1993: Skov K A; Adomat H; Farrell N P
Radiosensitization by nickel lapachol.
International journal of radiation biology 1993;64(6):707-13.
1993: Van Houten B; Illenye S; Qu Y; Farrell N
Homodinuclear (Pt,Pt) and heterodinuclear (Ru,Pt) metal compounds as DNA-protein cross-linking agents: potential suicide DNA lesions.
Biochemistry 1993;32(44):11794-801.
1993: Zou Y; Van Houten B; Farrell N
Ligand effects on platinum binding to DNA. A comparison of DNA binding properties for cis- and trans-[PtCl2(amine)2] (amine = NH3, pyridine).
Biochemistry 1993;32(37):9632-8.
1993: Farrell N
Nonclassical platinum antitumor agents: perspectives for design and development of new drugs complementary to cisplatin.
Cancer investigation 1993;11(5):578-89.
1992: Farrell N; Kelland L R; Roberts J D; Van Beusichem M
Activation of the trans geometry in platinum antitumor complexes: a survey of the cytotoxicity of trans complexes containing planar ligands in murine L1210 and human tumor panels and studies on their mechanism of action.
Cancer research 1992;52(18):5065-72.
1992: Johnson A; Qu Y; Van Houten B; Farrell N
B----Z DNA conformational changes induced by a family of dinuclear bis(platinum) complexes.
Nucleic acids research 1992;20(7):1697-703.
1990: Farrell N; Qu Y; Feng L; Van Houten B
Comparison of chemical reactivity, cytotoxicity, interstrand cross-linking and DNA sequence specificity of bis(platinum) complexes containing monodentate or bidentate coordination spheres with their monomeric analogues.
Biochemistry 1990;29(41):9522-31.
1990: Farrell N; Qu Y; Hacker M P
Cytotoxicity and antitumor activity of bis(platinum) complexes. A novel class of platinum complexes active in cell lines resistant to both cisplatin and 1,2-diaminocyclohexane complexes.
Journal of medicinal chemistry 1990;33(8):2179-84.
1990: Skov K A; Farrell N P
Radiosensitization by metal complexes of 4(5)-nitroimidazole.
International journal of radiation biology 1990;57(5):947-58.
1990: Skov K A; Adomat H; Chaplin D J; Farrell N P
Toxicity of [PtCl2(NH3)L] in hypoxia; L = misonidazole or metronidazole.
Anti-cancer drug design 1990;5(1):121-8.
1989: Roberts J D; Van Houten B; Qu Y; Farrell N P
Interaction of novel bis(platinum) complexes with DNA.
Nucleic acids research 1989;17(23):9719-33.
1989: Farrell N; Ha T T; Souchard J P; Wimmer F L; Cros S; Johnson N P
Cytostatic trans-platinum(II) complexes.
Journal of medicinal chemistry 1989;32(10):2240-1.
1987: Skov K A; Farrell N P; Adomat H
Platinum complexes with one radiosensitizing ligand [PtCl2(NH3) (sensitizer)]: radiosensitization and toxicity studies in vitro.
Radiation research 1987;112(2):273-82.
1987: Skov K A; Farrell N P
Binding mode of 2-amino-5-nitrothiazole (ANT) in platinum complexes, trans-[PtCl2(ANT)2], affects DNA binding, toxicity and radiosensitizing ability.
International journal of radiation biology and related studies in physics, chemistry, and medicine 1987;52(2):289-97.
1987: Skov K A; Adomat H; Konway D C; Farrell N P
Assessment of DNA binding of platinum-radiosensitizer complexes by inhibition of restriction enzymes.
Chemico-biological interactions 1987;62(2):117-29.
1986: Chan P K; Skov K A; James B R; Farrell N P
Chromosome-damaging activity of a ruthenium radiosensitizer, RuCl2 (DMSO)2 (4-nitroimidazole)2, in Chinese hamster ovary cells in vitro.
Chemico-biological interactions 1986;59(3):247-54.
1986: Chan P K; Skov K A; James B R; Farrell N P
A new ruthenium radiosensitizer: RuCl2(DMSO)2(4-nitroimidazole)2.
International journal of radiation oncology, biology, physics 1986;12(7):1059-62.

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