FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Paul Farrell

Research Profile

Living Beings

Human Herpesvirus 4

Chemicals & Drugs

Anatomy

Concepts & Ideas

Molecular Sequence Data

Disorders

Burkitt's Lymphoma

Physiology

Genes & Molecular Sequences

Genes, Viral

Co-author Network

Publications

TOP 3
Gareth Brady; Claudio Elgueta Karstegl; Paul J Farrell
Novel function of the unique N-terminal region of RUNX1c in B cell growth regulation.
Laila Cancian; Claudio Elgueta Karstegl; Walter Lucchesi; Rachel Bosshard; Paul J Farrell
C-terminal region of EBNA-2 determines the superior transforming ability of type 1 Epstein-Barr virus by enhanced gene regulation of LMP-1 and CXCR7.
Goran Gregorovic; Rachel Bosshard; Claudio Elgueta Karstegl; Robert E White; Samuel Pattle; Kwok Shing Chiang; Oliver Dittrich-Breiholz; Michael Kracht; Rainer Russ; Paul J Farrell
Cellular gene expression that correlates with EBER expression in Epstein-Barr Virus-infected lymphoblastoid cell lines.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Paul Farrell (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Gareth Brady; Claudio Elgueta Karstegl; Paul J Farrell
Novel function of the unique N-terminal region of RUNX1c in B cell growth regulation.
Nucleic acids research 2013;41(3):1555-68.
2011: Laila Cancian; Claudio Elgueta Karstegl; Walter Lucchesi; Rachel Bosshard; Paul J Farrell
C-terminal region of EBNA-2 determines the superior transforming ability of type 1 Epstein-Barr virus by enhanced gene regulation of LMP-1 and CXCR7.
PLoS pathogens 2011;7(7):e1002164.
2011: Goran Gregorovic; Rachel Bosshard; Claudio Elgueta Karstegl; Robert E White; Samuel Pattle; Kwok Shing Chiang; Oliver Dittrich-Breiholz; Michael Kracht; Rainer Russ; Paul J Farrell
Cellular gene expression that correlates with EBER expression in Epstein-Barr Virus-infected lymphoblastoid cell lines.
Journal of virology 2011;85(7):3535-45.
2010: Carol McDonald; Claudio Elgueta Karstegl; Kellam Paul; Paul J Farrell
Regulation of the Epstein-Barr virus Zp promoter in B lymphocytes during reactivation from latency.
The Journal of general virology 2010;91(Pt 3):622-9.
2009: Gareth Brady; Paul J Farrell
RUNX3-mediated repression of RUNX1 in B cells.
Journal of cellular physiology 2009;221(2):283-7.
2009: Gareth Brady; Hannah Whiteman; Lindsay C Spender; Paul J Farrell
Downregulation of RUNX1 by RUNX3 requires the RUNX3 VWRPY sequence and is essential for Epstein-Barr virus-driven B-cell proliferation.
Journal of virology 2009;83(13):6909-16.
2009: Carol M McDonald; Carlo Petosa; Paul J Farrell
Interaction of Epstein-Barr virus BZLF1 C-terminal tail structure and core zipper is required for DNA replication but not for promoter transactivation.
Journal of virology 2009;83(7):3397-401.
2009: Maha Al-Mozaini; Gustavo Bodelon; Claudio Elgueta Karstegl; Boquan Jin; Mohammed Al-Ahdal; Paul J Farrell
Epstein-Barr virus BART gene expression.
The Journal of general virology 2009;90(Pt 2):307-16.
2008: Walter Lucchesi; Gareth Brady; Oliver Dittrich-Breiholz; Michael Kracht; Rainer Russ; Paul J Farrell
Differential gene regulation by Epstein-Barr virus type 1 and type 2 EBNA2.
Journal of virology 2008;82(15):7456-66.
2008: G Brady; G J Macarthur; Paul J Farrell
Epstein-Barr virus and Burkitt lymphoma.
Postgraduate medical journal 2008;84(993):372-7.
2007: G Brady; G J MacArthur; Paul J Farrell
Epstein-Barr virus and Burkitt lymphoma.
Journal of clinical pathology 2007;60(12):1397-402.
2007: Paul J Farrell
Role for HLA in susceptibility to infectious mononucleosis.
The Journal of clinical investigation 2007;117(10):2756-8.
2006: Samuel B Pattle; Paul J Farrell
The role of Epstein-Barr virus in cancer.
Expert opinion on biological therapy 2006;6(11):1193-205.
2006: Lindsay C Spender; Walter Lucchesi; Gustavo Bodelon; Antonio Bilancio; Claudio Elgueta Karstegl; Tomoichiro Asano; Oliver Dittrich-Breiholz; Michael Kracht; Bart Vanhaesebroeck; Paul J Farrell
Cell target genes of Epstein-Barr virus transcription factor EBNA-2: induction of the p55alpha regulatory subunit of PI3-kinase and its role in survival of EREB2.5 cells.
The Journal of general virology 2006;87(Pt 10):2859-67.
2006: Wolfgang Amon; Robert E White; Paul J Farrell
Epstein-Barr virus origin of lytic replication mediates association of replicating episomes with promyelocytic leukaemia protein nuclear bodies and replication compartments.
The Journal of general virology 2006;87(Pt 5):1133-7.
2006: Hannah Whiteman; Paul J Farrell
RUNX expression and function in human B cells.
Critical reviews in eukaryotic gene expression 2006;16(1):31-44.
2006: Nelofer Syed; Paul Smith; Alexandra Sullivan; Lindsay C Spender; Martin Dyer; Lorraine Karran; Jenny O'nions; Martin J Allday; Ingrid Hoffmann; Dorothy Crawford; Beverley Griffin; Paul J Farrell; Tim Crook
Transcriptional silencing of Polo-like kinase 2 (SNK/PLK2) is a frequent event in B-cell malignancies.
Blood 2006;107(1):250-6.
2005: Wolfgang Amon; Paul J Farrell
Reactivation of Epstein-Barr virus from latency.
Reviews in medical virology 2005;15(3):149-56.
2005: Lindsay C Spender; Hannah Whiteman; Claudio Elgueta Karstegl; Paul J Farrell
Transcriptional cross-regulation of RUNX1 by RUNX3 in human B cells.
Oncogene 2005;24(11):1873-81.
2005: Paul J Farrell
Can plasma Epstein-Barr virus DNA levels be used to monitor nasopharyngeal carcinoma progression?
Nature clinical practice. Oncology 2005;2(1):14-5.
2004: Wolfgang Amon; Ulrich K Binné; Helen Bryant; Peter J Jenkins; Claudio Elgueta Karstegl; Paul J Farrell
Lytic cycle gene regulation of Epstein-Barr virus.
Journal of virology 2004;78(24):13460-9.
2004: Alexandra Sullivan; Nelofer Syed; Milena Gasco; Daniele Bergamaschi; Giuseppe Trigiante; Marlene Attard; Louise Hiller; Paul J Farrell; Paul Smith; Xin Lu; Tim Crook
Polymorphism in wild-type p53 modulates response to chemotherapy in vitro and in vivo.
Oncogene 2004;23(19):3328-37.
2003: Orlando de Jesus; Paul R Smith; Lindsay C Spender; Claudio Elgueta Karstegl; Hans Helmut Niller; Dolly Huang; Paul J Farrell
Updated Epstein-Barr virus (EBV) DNA sequence and analysis of a promoter for the BART (CST, BARF0) RNAs of EBV.
The Journal of general virology 2003;84(Pt 6):1443-50.
2003: Daniele Bergamaschi; Milena Gasco; Louise Hiller; Alexandra Sullivan; Nelofer Syed; Giuseppe Trigiante; Isik G Yulug; Marco Merlano; Gianmauro Numico; Alberto Comino; Marlene Attard; Olivier Reelfs; Barry A Gusterson; Alexandra K Bell; Victoria Heath; Mahvash Tavassoli; Paul J Farrell; Paul Smith; Xin Lu; Tim Crook
p53 polymorphism influences response in cancer chemotherapy via modulation of p73-dependent apoptosis.
Cancer cell 2003;3(4):387-402.
2002: Helen Bryant; Paul J Farrell
Signal Transduction and Transcription Factor Modification during Reactivation of Epstein-Barr Virus from Latency.
Journal of virology 2002;76(20):10290-8.
2002: Ulrich K Binné; Wolfgang Amon; Paul J Farrell
Promoter sequences required for reactivation of Epstein-Barr virus from latency.
Journal of virology 2002;76(20):10282-9.
2002: Lindsay C Spender; Georgina H Cornish; Alexandra Sullivan; Paul J Farrell
Expression of transcription factor AML-2 (RUNX3, CBF(alpha)-3) is induced by Epstein-Barr virus EBNA-2 and correlates with the B-cell activation phenotype.
Journal of virology 2002;76(10):4919-27.
2002: Milena Gasco; Alexandra K Bell; Victoria Heath; Alexandra Sullivan; Paul Smith; Louise Hiller; Isik G Yulug; Gianmauro Numico; Marco Merlano; Paul J Farrell; Mahvash Tavassoli; Barry A Gusterson; Tim Crook
Epigenetic inactivation of 14-3-3 sigma in oral carcinoma: association with p16(INK4a) silencing and human papillomavirus negativity.
Cancer research 2002;62(7):2072-6.
2002: Milena Gasco; Alexandra Sullivan; Claire Repellin; Louise Brooks; Paul J Farrell; John Tidy; Barbara Dunne; Barry A Gusterson; David J Evans; Tim Crook
Coincident inactivation of 14-3-3sigma and p16INK4a is an early event in vulval squamous neoplasia.
Oncogene 2002;21(12):1876-81.
2002: Archana Reddy; Martin Yuille; Alexandra Sullivan; Claire Repellin; Alexandra Bell; John Tidy; David J Evans; Paul J Farrell; Barry A Gusterson; Milena Gasco; Tim Crook
Analysis of CHK2 in vulval neoplasia.
British journal of cancer 2002;86(5):756-60.
2002: Alexandra Sullivan; Martin Yuille; Claire Repellin; Archana Reddy; Olivier Reelfs; Alexandra Bell; Barbara Dunne; Barry A Gusterson; Peter Osin; Paul J Farrell; Isik G Yulug; Abigail Evans; Tayfun Ozcelik; Milena Gasco; Tim Crook
Concomitant inactivation of p53 and Chk2 in breast cancer.
Oncogene 2002;21(9):1316-24.
2002: LA Brooks; Alexandra Sullivan; Jenny O'nions; Alexandra Bell; Barbara Dunne; John Tidy; David J Evans; Peter Osin; K H Vousden; Barry A Gusterson; Paul J Farrell; Alan Storey; Milena Gasco; T Sakai; Tim Crook
E7 proteins from oncogenic human papillomavirus types transactivate p73: role in cervical intraepithelial neoplasia.
British journal of cancer 2002;86(2):263-8.
2001: Jenny O'nions; LA Brooks; Alexandra Sullivan; Alexandra Bell; Barbara Dunne; M Rozycka; Archana Reddy; John Tidy; D Evans; Paul J Farrell; A Evans; Milena Gasco; Barry A Gusterson; Tim Crook
p73 is over-expressed in vulval cancer principally as the Delta 2 isoform.
British journal of cancer 2001;85(10):1551-6.
2001: B Wensing; A Stühler; P Jenkins; M Hollyoake; Claudio Elgueta Karstegl; Paul J Farrell
Variant chromatin structure of the oriP region of Epstein-Barr virus and regulation of EBER1 expression by upstream sequences and oriP.
Journal of virology 2001;75(13):6235-41.
2001: Lindsay C Spender; Georgina H Cornish; Benjamin Rowland; B Kempkes; Paul J Farrell
Direct and indirect regulation of cytokine and cell cycle proteins by EBNA-2 during Epstein-Barr virus infection.
Journal of virology 2001;75(8):3537-46.
2001: GJ Inman; Ulrich K Binné; Gillian A Parker; Paul J Farrell; Martin J Allday
Activators of the Epstein-Barr virus lytic program concomitantly induce apoptosis, but lytic gene expression protects from cell death.
Journal of virology 2001;75(5):2400-10.
2000: LA Brooks; John Tidy; Barry A Gusterson; Louise Hiller; Jenny O'nions; Milena Gasco; Maria Carmen Marin; Paul J Farrell; William G Kaelin; Tim Crook
Preferential retention of codon 72 arginine p53 in squamous cell carcinomas of the vulva occurs in cancers positive and negative for human papillomavirus.
Cancer research 2000;60(24):6875-7.
2000: Paul R Smith; O de Jesus; D Turner; M Hollyoake; Claudio Elgueta Karstegl; Beverly E Griffin; Lorraine Karran; Y Wang; S Diane Hayward; Paul J Farrell
Structure and coding content of CST (BART) family RNAs of Epstein-Barr virus.
Journal of virology 2000;74(7):3082-92.
2000: B Wensing; Paul J Farrell
Regulation of cell growth and death by Epstein-Barr virus.
Microbes and infection / Institut Pasteur 2000;2(1):77-84.
2000: P J Jenkins; Ulrich K Binné; Paul J Farrell
Histone acetylation and reactivation of Epstein-Barr virus from latency.
Journal of virology 2000;74(2):710-20.
1999: A Kiermaier; JM Gawn; L Desbarats; Rainer Saffrich; Wilhelm Ansorge; Paul J Farrell; Martin Eilers; Graham Packham
DNA binding of USF is required for specific E-box dependent gene activation in vivo.
Oncogene 1999;18(51):7200-11.
1999: Lindsay C Spender; E J Cannell; M Hollyoake; B Wensing; JM Gawn; Matthew Brimmell; Graham Packham; Paul J Farrell
Control of cell cycle entry and apoptosis in B lymphocytes infected by Epstein-Barr virus.
Journal of virology 1999;73(6):4678-88.
1998: E J Cannell; Paul J Farrell; A J Sinclair
Cell cycle arrest following exposure of EBV-immortalised B-cells to gamma irradiation correlates with inhibition of cdk2 activity.
FEBS letters 1998;439(3):297-301.
1998: Paul J Farrell
Signal transduction from the Epstein-Barr virus LMP-1 transforming protein.
Trends in microbiology 1998;6(5):175-7; discussion 177-8.
1998: I Cludts; Paul J Farrell
Multiple functions within the Epstein-Barr virus EBNA-3A protein.
Journal of virology 1998;72(3):1862-9.
1997: S A Radkov; M Bain; Paul J Farrell; M West; M Rowe; Martin J Allday
Epstein-Barr virus EBNA3C represses Cp, the major promoter for EBNA expression, but has no effect on the promoter of the cell gene CD21.
Journal of virology 1997;71(11):8552-62.
1997: Paul J Farrell; M Hollyoake; Gerald Niedobitek; Angelo Agathanggelou; A Morgan; Nina Wedderburn
Direct demonstration of persistent Epstein-Barr virus gene expression in peripheral blood of infected common marmosets and analysis of virus-infected tissues in vivo.
The Journal of general virology 1997;78 ( Pt 6)():1417-24.
1997: T J Evans; Louise Brooks; Paul J Farrell
A strategy for specific targeting of therapeutic agents to tumour cells of virus-associated cancers.
Gene therapy 1997;4(3):264-7.
1997: Paul J Farrell; I Cludts; A Stühler
Epstein-Barr virus genes and cancer cells.
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 1997;51(6-7):258-67.
1996: G A Parker; Tim Crook; M Bain; E A Sara; Paul J Farrell; Martin J Allday
Epstein-Barr virus nuclear antigen (EBNA)3C is an immortalizing oncoprotein with similar properties to adenovirus E1A and papillomavirus E7.
Oncogene 1996;13(12):2541-9.
1996: E J Cannell; Paul J Farrell; A J Sinclair
Epstein-Barr virus exploits the normal cell pathway to regulate Rb activity during the immortalisation of primary B-cells.
Oncogene 1996;13(7):1413-21.
1996: M Bain; R J Watson; Paul J Farrell; Martin J Allday
Epstein-Barr virus nuclear antigen 3C is a powerful repressor of transcription when tethered to DNA.
Journal of virology 1996;70(4):2481-9.
1996: T J Evans; Paul J Farrell; S Swaminathan
Molecular genetic analysis of Epstein-Barr virus Cp promoter function.
Journal of virology 1996;70(3):1695-705.
1995: Martin J Allday; G J Inman; D H Crawford; Paul J Farrell
DNA damage in human B cells can induce apoptosis, proceeding from G1/S when p53 is transactivation competent and G2/M when it is transactivation defective.
The EMBO journal 1995;14(20):4994-5005.
1995: G J Inman; Paul J Farrell
Epstein-Barr virus EBNA-LP and transcription regulation properties of pRB, p107 and p53 in transfection assays.
The Journal of general virology 1995;76 ( Pt 9)():2141-9.
1995: A J Sinclair; Paul J Farrell
Host cell requirements for efficient infection of quiescent primary B lymphocytes by Epstein-Barr virus.
Journal of virology 1995;69(9):5461-8.
1995: L Brooks; Gerald Niedobitek; Angelo Agathanggelou; Paul J Farrell
The expression of variant CD44 in nasopharyngeal carcinoma is unrelated to expression of LMP-1.
The American journal of pathology 1995;146(5):1102-12.
1995: Martin J Allday; A Sinclair; G Parker; D H Crawford; Paul J Farrell
Epstein-Barr virus efficiently immortalizes human B cells without neutralizing the function of p53.
The EMBO journal 1995;14(7):1382-91.
1995: Paul J Farrell
Epstein-Barr virus immortalizing genes.
Trends in microbiology 1995;3(3):105-9.
1995: T J Evans; M G Jacquemin; Paul J Farrell
Efficient EBV superinfection of group I Burkitt's lymphoma cells distinguishes requirements for expression of the Cp viral promoter and can activate the EBV productive cycle.
Virology 1995;206(2):866-77.
1995: A J Sinclair; Ignacio Palmero; A Holder; Gordon Peters; Paul J Farrell
Expression of cyclin D2 in Epstein-Barr virus-positive Burkitt's lymphoma cell lines is related to methylation status of the gene.
Journal of virology 1995;69(2):1292-5.
1995: D Horner; M Lewis; Paul J Farrell
Novel hypotheses for the roles of EBNA-1 and BHRF1 in EBV-related cancers.
Intervirology 1995;38(3-4):195-205.
1994: I D Cook; F Shanahan; Paul J Farrell
Epstein-Barr virus SM protein.
Virology 1994;205(1):217-27.
1994: A J Sinclair; Ignacio Palmero; Gordon Peters; Paul J Farrell
EBNA-2 and EBNA-LP cooperate to cause G0 to G1 transition during immortalization of resting human B lymphocytes by Epstein-Barr virus.
The EMBO journal 1994;13(14):3321-8.
1994: Martin J Allday; Paul J Farrell
Epstein-Barr virus nuclear antigen EBNA3C/6 expression maintains the level of latent membrane protein 1 in G1-arrested cells.
Journal of virology 1994;68(6):3491-8.
1994: A J Sinclair; M G Jacquemin; L Brooks; F Shanahan; Matthew Brimmell; M Rowe; Paul J Farrell
Reduced signal transduction through glucocorticoid receptor in Burkitt's lymphoma cell lines.
Virology 1994;199(2):339-53.
1993: R Lau; Jaap Middeldorp; Paul J Farrell
Epstein-Barr virus gene expression in oral hairy leukoplakia.
Virology 1993;195(2):463-74.
1993: Karen H Vousden; Tim Crook; Paul J Farrell
Biological activities of p53 mutants in Burkitt's lymphoma cells.
The Journal of general virology 1993;74 ( Pt 5)():803-10.
1993: Graham Packham; Matthew Brimmell; D Cook; A J Sinclair; Paul J Farrell
Strain variation in Epstein-Barr virus immediate early genes.
Virology 1993;192(2):541-50.
1992: R Lau; Graham Packham; Paul J Farrell
Differential splicing of Epstein-Barr virus immediate-early RNA.
Journal of virology 1992;66(10):6233-6.
1992: A J Sinclair; Paul J Farrell
Epstein-Barr virus transcription factors.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1992;3(8):557-63.
1992: G J Allan; G J Inman; B D Parker; D T Rowe; Paul J Farrell
Cell growth effects of Epstein-Barr virus leader protein.
The Journal of general virology 1992;73 ( Pt 6)():1547-51.
1992: A J Sinclair; Matthew Brimmell; Paul J Farrell
Reciprocal antagonism of steroid hormones and BZLF1 in switch between Epstein-Barr virus latent and productive cycle gene expression.
Journal of virology 1992;66(1):70-7.
1992: C M Rooney; Matthew Brimmell; M Buschle; G Allan; Paul J Farrell; J L Kolman
Host cell and EBNA-2 regulation of Epstein-Barr virus latent-cycle promoter activity in B lymphocytes.
Journal of virology 1992;66(1):496-504.
1991: Paul J Farrell; G J Allan; F Shanahan; Karen H Vousden; Tim Crook
p53 is frequently mutated in Burkitt's lymphoma cell lines.
The EMBO journal 1991;10(10):2879-87.
1991: A J Sinclair; Matthew Brimmell; F Shanahan; Paul J Farrell
Pathways of activation of the Epstein-Barr virus productive cycle.
Journal of virology 1991;65(5):2237-44.
1991: T Kouzarides; Graham Packham; A Cook; Paul J Farrell
The BZLF1 protein of EBV has a coiled coil dimerisation domain without a heptad leucine repeat but with homology to the C/EBP leucine zipper.
Oncogene 1991;6(2):195-204.
1990: B D Parker; A Bankier; S Satchwell; B Barrell; Paul J Farrell
Sequence and transcription of Raji Epstein-Barr virus DNA spanning the B95-8 deletion region.
Virology 1990;179(1):339-46.
1990: Graham Packham; A Economou; C M Rooney; D T Rowe; Paul J Farrell
Structure and function of the Epstein-Barr virus BZLF1 protein.
Journal of virology 1990;64(5):2110-6.
1989: G Laux; A Economou; Paul J Farrell
The terminal protein gene 2 of Epstein-Barr virus is transcribed from a bidirectional latent promoter region.
The Journal of general virology 1989;70 ( Pt 11)():3079-84.
1989: C M Rooney; D T Rowe; T Ragot; Paul J Farrell
The spliced BZLF1 gene of Epstein-Barr virus (EBV) transactivates an early EBV promoter and induces the virus productive cycle.
Journal of virology 1989;63(7):3109-16.
1989: J Tidy; Karen H Vousden; P Mason; Paul J Farrell
A novel deletion within the upstream regulatory region of episomal human papillomavirus type 16.
The Journal of general virology 1989;70 ( Pt 4)():999-1004.
1989: Paul J Farrell; D T Rowe; C M Rooney; T Kouzarides
Epstein-Barr virus BZLF1 trans-activator specifically binds to a consensus AP-1 site and is related to c-fos.
The EMBO journal 1989;8(1):127-32.
1988: G Laux; M Perricaudet; Paul J Farrell
A spliced Epstein-Barr virus gene expressed in immortalized lymphocytes is created by circularization of the linear viral genome.
The EMBO journal 1988;7(3):769-74.
1987: M Bodescot; M Perricaudet; Paul J Farrell
A promoter for the highly spliced EBNA family of RNAs of Epstein-Barr virus.
Journal of virology 1987;61(11):3424-30.
1987: I Joab; D T Rowe; M Bodescot; J C Nicolas; Paul J Farrell; M Perricaudet
Mapping of the gene coding for Epstein-Barr virus-determined nuclear antigen EBNA3 and its transient overexpression in a human cell line by using an adenovirus expression vector.
Journal of virology 1987;61(10):3340-4.
1987: Martin Rowe; D T Rowe; Christopher D Gregory; Lawrence S Young; Paul J Farrell; H Rupani; Alan B Rickinson
Differences in B cell growth phenotype reflect novel patterns of Epstein-Barr virus latent gene expression in Burkitt's lymphoma cells.
The EMBO journal 1987;6(9):2743-51.
1987: D T Rowe; Paul J Farrell; I G Miller
Novel nuclear antigens recognized by human sera in lymphocytes latently infected by Epstein-Barr virus.
Virology 1987;156(1):153-62.
1986: D T Rowe; Martin Rowe; G I Evan; L E Wallace; Paul J Farrell; Alan B Rickinson
Restricted expression of EBV latent genes and T-lymphocyte-detected membrane antigen in Burkitt's lymphoma cells.
The EMBO journal 1986;5(10):2599-607.