Reinhard Fässler

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Tiede Stephan; Koop Norbert; Kloepper Jennifer E; Fässler Reinhard; Paus Ralf
Nonviral in situ green fluorescent protein labeling and culture of primary, adult human hair follicle epithelial progenitor cells.
Lange Anika; Wickström Sara A; Jakobson Madis; Zent Roy; Sainio Kirsi; Fässler Reinhard
Integrin-linked kinase is an adaptor with essential functions during mouse development.
Montanez Eloi; Wickström Sara A; Altstätter Johannes; Chu Haiyan; Fässler Reinhard
Alpha-parvin controls vascular mural cell recruitment to vessel wall by regulating RhoA/ROCK signalling.

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All Publications

2009: Tiede Stephan; Koop Norbert; Kloepper Jennifer E; Fässler Reinhard; Paus Ralf
Nonviral in situ green fluorescent protein labeling and culture of primary, adult human hair follicle epithelial progenitor cells.
Stem cells (Dayton, Ohio) 2009;27(11):2793-803.
2009: Lange Anika; Wickström Sara A; Jakobson Madis; Zent Roy; Sainio Kirsi; Fässler Reinhard
Integrin-linked kinase is an adaptor with essential functions during mouse development.
Nature 2009;461(7266):1002-6.
2009: Montanez Eloi; Wickström Sara A; Altstätter Johannes; Chu Haiyan; Fässler Reinhard
Alpha-parvin controls vascular mural cell recruitment to vessel wall by regulating RhoA/ROCK signalling.
The EMBO journal 2009;28(20):3132-44.
2009: Kogata Naoko; Tribe Rachel M; Fässler Reinhard; Way Michael; Adams Ralf H
Integrin-linked kinase controls vascular wall formation by negatively regulating Rho/ROCK-mediated vascular smooth muscle cell contraction.
Genes & development 2009;23(19):2278-83.
2009: Meves Alexander; Stremmel Christopher; Gottschalk Kay; Fässler Reinhard
The Kindlin protein family: new members to the club of focal adhesion proteins.
Trends in cell biology 2009;19(10):504-13.
2009: Zhang Xi; Mernaugh Glenda; Yang Dong-Hua; Gewin Leslie; Srichai Manakan B; Harris Raymond C; Iturregui Juan M; Nelson Raoul D; Kohan Donald E; Abrahamson Dale; Fässler Reinhard; Yurchenco Peter; Pozzi Ambra; Zent Roy
beta1 integrin is necessary for ureteric bud branching morphogenesis and maintenance of collecting duct structural integrity.
Development (Cambridge, England) 2009;136(19):3357-66.
2009: Böttcher Ralph T; Lange Anika; Fässler Reinhard
How ILK and kindlins cooperate to orchestrate integrin signaling.
Current opinion in cell biology 2009;21(5):670-5.
2009: Wickström Sara A; Fässler Reinhard
Integrins anchor the invasive machinery.
Developmental cell 2009;17(2):158-60.
2009: Dours-Zimmermann María T; Maurer Konrad; Rauch Uwe; Stoffel Wilhelm; Fässler Reinhard; Zimmermann Dieter R
Versican V2 assembles the extracellular matrix surrounding the nodes of ranvier in the CNS.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(24):7731-42.
2009: Schlomann Uwe; Schwamborn Jens C; Müller Myriam; Fässler Reinhard; Püschel Andreas W
The stimulation of dendrite growth by Sema3A requires integrin engagement and focal adhesion kinase.
Journal of cell science 2009;122(Pt 12):2034-42.
2009: Stanchi Fabio; Grashoff Carsten; Nguemeni Yonga Carine Flore; Grall Dominique; Fässler Reinhard; Van Obberghen-Schilling Ellen
Molecular dissection of the ILK-PINCH-parvin triad reveals a fundamental role for the ILK kinase domain in the late stages of focal-adhesion maturation.
Journal of cell science 2009;122(Pt 11):1800-11.
2009: Kim Minsoo; Ogawa Michinaga; Fujita Yukihiro; Yoshikawa Yuko; Nagai Takeshi; Koyama Tomohiro; Nagai Shinya; Lange Anika; Fässler Reinhard; Sasakawa Chihiro
Bacteria hijack integrin-linked kinase to stabilize focal adhesions and block cell detachment.
Nature 2009;459(7246):578-82.
2009: Moser Markus; Legate Kyle R; Zent Roy; Fässler Reinhard
The tail of integrins, talin, and kindlins.
Science (New York, N.Y.) 2009;324(5929):895-9.
2009: Pereira Jorge A; Benninger Yves; Baumann Reto; Gonçalves Ana Filipa; Ozçelik Murat; Thurnherr Tina; Tricaud Nicolas; Meijer Dies; Fässler Reinhard; Suter Ueli; Relvas João B
Integrin-linked kinase is required for radial sorting of axons and Schwann cell remyelination in the peripheral nervous system.
The Journal of cell biology 2009;185(1):147-61.
2009: Cantor Joseph; Browne Cecille D; Ruppert Raphael; Féral Chloé C; Fässler Reinhard; Rickert Robert C; Ginsberg Mark H
CD98hc facilitates B cell proliferation and adaptive humoral immunity.
Nature immunology 2009;10(4):412-9.
2009: Böttcher Ralph T; Wiesner Sebastian; Braun Attila; Wimmer Reiner; Berna Alejandro; Elad Nadav; Medalia Ohad; Pfeifer Alexander; Aszódi Attila; Costell Mercedes; Fässler Reinhard
Profilin 1 is required for abscission during late cytokinesis of chondrocytes.
The EMBO journal 2009;28(8):1157-69.
2009: Moser Markus; Bauer Martina; Schmid Stephan; Ruppert Raphael; Schmidt Sarah; Sixt Michael; Wang Hao-Ven; Sperandio Markus; Fässler Reinhard
Kindlin-3 is required for beta2 integrin-mediated leukocyte adhesion to endothelial cells.
Nature medicine 2009;15(3):300-5.
2009: Legate Kyle R; Wickström Sara A; Fässler Reinhard
Genetic and cell biological analysis of integrin outside-in signaling.
Genes & development 2009;23(4):397-418.
2009: Bauer Martina; Brakebusch Cord; Coisne Caroline; Sixt Michael; Wekerle Hartmut; Engelhardt Britta; Fässler Reinhard
Beta1 integrins differentially control extravasation of inflammatory cell subsets into the CNS during autoimmunity.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(6):1920-5.
2009: Massoumi Ramin; Kuphal Silke; Hellerbrand Claus; Haas Bodo; Wild Peter; Spruss Thilo; Pfeifer Alexander; Fässler Reinhard; Bosserhoff Anja K
Down-regulation of CYLD expression by Snail promotes tumor progression in malignant melanoma.
The Journal of experimental medicine 2009;206(1):221-32.
2009: Liu Jie; He Xiaowen; Corbett Siobhan A; Lowry Stephen F; Graham Alan M; Fässler Reinhard; Li Shaohua
Integrins are required for the differentiation of visceral endoderm.
Journal of cell science 2009;122(Pt 2):233-42.
2009: Legate Kyle R; Fässler Reinhard
Mechanisms that regulate adaptor binding to beta-integrin cytoplasmic tails.
Journal of cell science 2009;122(Pt 2):187-98.
2009: Piwko-Czuchra Aleksandra; Koegel Heidi; Meyer Hannelore; Bauer Martina; Werner Sabine; Brakebusch Cord; Fässler Reinhard
Beta1 integrin-mediated adhesion signalling is essential for epidermal progenitor cell expansion.
PloS one 2009;4(5):e5488.
2008: Zanivan Sara; Gnad Florian; Wickström Sara A; Geiger Tami; Macek Boris; Cox Jürgen; Fässler Reinhard; Mann Matthias
Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry.
Journal of proteome research 2008;7(12):5314-26.
2008: Ussar Siegfried; Moser Markus; Widmaier Moritz; Rognoni Emanuel; Harrer Christian; Genzel-Boroviczeny Orsolya; Fässler Reinhard
Loss of Kindlin-1 causes skin atrophy and lethal neonatal intestinal epithelial dysfunction.
PLoS genetics 2008;4(12):e1000289.
2008: Egea Joaquim; Erlacher Christian; Montanez Eloi; Burtscher Ingo; Yamagishi Satoru; Hess Martin; Hampel Falko; Sanchez Rodrigo; Rodriguez-Manzaneque Maria Teresa; Bösl Michael R; Fässler Reinhard; Lickert Heiko; Klein Rüdiger
Genetic ablation of FLRT3 reveals a novel morphogenetic function for the anterior visceral endoderm in suppressing mesoderm differentiation.
Genes & development 2008;22(23):3349-62.
2008: Kanatsu-Shinohara Mito; Takehashi Masanori; Takashima Seiji; Lee Jiyoung; Morimoto Hiroko; Chuma Shinichiro; Raducanu Aurelia; Nakatsuji Norio; Fässler Reinhard; Shinohara Takashi
Homing of mouse spermatogonial stem cells to germline niche depends on beta1-integrin.
Cell stem cell 2008;3(5):533-42.
2008: Salmenperä Pertteli; Kankuri Esko; Bizik Jozef; Sirén Vappu; Virtanen Ismo; Takahashi Seiichiro; Leiss Michael; Fässler Reinhard; Vaheri Antti
Formation and activation of fibroblast spheroids depend on fibronectin-integrin interaction.
Experimental cell research 2008;314(19):3444-52.
2008: Leiss Michael; Beckmann Karsten; Girós Amparo; Costell Mercedes; Fässler Reinhard
The role of integrin binding sites in fibronectin matrix assembly in vivo.
Current opinion in cell biology 2008;20(5):502-7.
2008: Pellinen Teijo; Tuomi Saara; Arjonen Antti; Wolf Maija; Edgren Henrik; Meyer Hannelore; Grosse Robert; Kitzing Thomas; Rantala Juha K; Kallioniemi Olli; Fässler Reinhard; Kallio Marko; Ivaska Johanna
Integrin trafficking regulated by Rab21 is necessary for cytokinesis.
Developmental cell 2008;15(3):371-85.
2008: Huveneers Stephan; Truong Hoa; Fässler Reinhard; Sonnenberg Arnoud; Danen Erik H J
Binding of soluble fibronectin to integrin alpha5 beta1 - link to focal adhesion redistribution and contractile shape.
Journal of cell science 2008;121(Pt 15):2452-62.
2008: Krüger Marcus; Moser Markus; Ussar Siegfried; Thievessen Ingo; Luber Christian A; Forner Francesca; Schmidt Sarah; Zanivan Sara; Fässler Reinhard; Mann Matthias
SILAC mouse for quantitative proteomics uncovers kindlin-3 as an essential factor for red blood cell function.
Cell 2008;134(2):353-64.
2008: Kessenbrock Kai; Fröhlich Leopold; Sixt Michael; Lämmermann Tim; Pfister Heiko; Bateman Andrew; Belaaouaj Azzaq; Ring Johannes; Ollert Markus; Fässler Reinhard; Jenne Dieter E
Proteinase 3 and neutrophil elastase enhance inflammation in mice by inactivating antiinflammatory progranulin.
The Journal of clinical investigation 2008;118(7):2438-47.
2008: Taddei Ilaria; Deugnier Marie-Ange; Faraldo Marisa M; Petit Valérie; Bouvard Daniel; Medina Daniel; Fässler Reinhard; Thiery Jean Paul; Glukhova Marina A
Beta1 integrin deletion from the basal compartment of the mammary epithelium affects stem cells.
Nature cell biology 2008;10(6):716-22.
2008: Montanez Eloi; Ussar Siegfried; Schifferer Martina; Bösl Michael; Zent Roy; Moser Markus; Fässler Reinhard
Kindlin-2 controls bidirectional signaling of integrins.
Genes & development 2008;22(10):1325-30.
2008: Lämmermann Tim; Bader Bernhard L; Monkley Susan J; Worbs Tim; Wedlich-Söldner Roland; Hirsch Karin; Keller Markus; Förster Reinhold; Critchley David R; Fässler Reinhard; Sixt Michael
Rapid leukocyte migration by integrin-independent flowing and squeezing.
Nature 2008;453(7191):51-5.
2008: Fritsch Anja; Loeckermann Stefan; Kern Johannes S; Braun Attila; Bösl Michael R; Bley Thorsten A; Schumann Hauke; von Elverfeldt Dominik; Paul Dominik; Erlacher Miriam; Berens von Rautenfeld Dirk; Hausser Ingrid; Fässler Reinhard; Bruckner-Tuderman Leena
A hypomorphic mouse model of dystrophic epidermolysis bullosa reveals mechanisms of disease and response to fibroblast therapy.
The Journal of clinical investigation 2008;118(5):1669-79.
2008: Wang Hao-Ven; Chang Ling-Wei; Brixius Klara; Wickström Sara A; Montanez Eloi; Thievessen Ingo; Schwander Martin; Müller Ulrich; Bloch Wilhelm; Mayer Ulrike; Fässler Reinhard
Integrin-linked kinase stabilizes myotendinous junctions and protects muscle from stress-induced damage.
The Journal of cell biology 2008;180(5):1037-49.
2008: Moser Markus; Nieswandt Bernhard; Ussar Siegfried; Pozgajova Miroslava; Fässler Reinhard
Kindlin-3 is essential for integrin activation and platelet aggregation.
Nature medicine 2008;14(3):325-30.
2008: Bouabe Hicham; Fässler Reinhard; Heesemann Jürgen
Improvement of reporter activity by IRES-mediated polycistronic reporter system.
Nucleic acids research 2008;36(5):e28.
2008: Abraham Sabu; Kogata Naoko; Fässler Reinhard; Adams Ralf H
Integrin beta1 subunit controls mural cell adhesion, spreading, and blood vessel wall stability.
Circulation research 2008;102(5):562-70.
2008: Kloepper J E; Hendrix S; Bodó E; Tiede S; Humphries M J; Philpott M P; Fässler R; Paus R
Functional role of beta 1 integrin-mediated signalling in the human hair follicle.
Experimental cell research 2008;314(3):498-508.
2007: Nieswandt Bernhard; Moser Markus; Pleines Irina; Varga-Szabo David; Monkley Sue; Critchley David; Fässler Reinhard
Loss of talin1 in platelets abrogates integrin activation, platelet aggregation, and thrombus formation in vitro and in vivo.
The Journal of experimental medicine 2007;204(13):3113-8.
2007: Suemoto Hiroki; Muragaki Yasuteru; Nishioka Katsuhiro; Sato Misako; Ooshima Akira; Itoh Shunji; Hatamura Ikuji; Ozaki Michitaka; Braun Attila; Gustafsson Erika; Fässler Reinhard
Trps1 regulates proliferation and apoptosis of chondrocytes through Stat3 signaling.
Developmental biology 2007;312(2):572-81.
2007: Furman Craig; Sieminski Alisha L; Kwiatkowski Adam V; Rubinson Douglas A; Vasile Eliza; Bronson Roderick T; Fässler Reinhard; Gertler Frank B
Ena/VASP is required for endothelial barrier function in vivo.
The Journal of cell biology 2007;179(4):761-75.
2007: Kwiatkowski Adam V; Rubinson Douglas A; Dent Erik W; Edward van Veen J; Leslie Jonathan D; Zhang Jiangyang; Mebane Leslie M; Philippar Ulrike; Pinheiro Elaine M; Burds Aurora A; Bronson Roderick T; Mori Susumu; Fässler Reinhard; Gertler Frank B
Ena/VASP Is Required for neuritogenesis in the developing cortex.
Neuron 2007;56(3):441-55.
2007: Hövelmeyer Nadine; Wunderlich F Thomas; Massoumi Ramin; Jakobsen Charlotte G; Song Jian; Wörns Marcus A; Merkwirth Carsten; Kovalenko Andrew; Aumailley Monique; Strand Dennis; Brüning Jens C; Galle Peter R; Wallach David; Fässler Reinhard; Waisman Ari
Regulation of B cell homeostasis and activation by the tumor suppressor gene CYLD.
The Journal of experimental medicine 2007;204(11):2615-27.
2007: Leamey Catherine A; Merlin Sam; Lattouf Paul; Sawatari Atomu; Zhou Xiaohong; Demel Natasha; Glendining Kelly A; Oohashi Toshitaka; Sur Mriganka; Fässler Reinhard
Ten_m3 regulates eye-specific patterning in the mammalian visual pathway and is required for binocular vision.
PLoS biology 2007;5(9):e241.
2007: Takahashi Seiichiro; Leiss Michael; Moser Markus; Ohashi Tomoo; Kitao Tomoe; Heckmann Dominik; Pfeifer Alexander; Kessler Horst; Takagi Junichi; Erickson Harold P; Fässler Reinhard
The RGD motif in fibronectin is essential for development but dispensable for fibril assembly.
The Journal of cell biology 2007;178(1):167-78.
2007: Bouvard Daniel; Aszodi Attila; Kostka Günter; Block Marc R; Albigès-Rizo Corinne; Fässler Reinhard
Defective osteoblast function in ICAP-1-deficient mice.
Development (Cambridge, England) 2007;134(14):2615-25.
2007: Kren Angelika; Baeriswyl Vanessa; Lehembre François; Wunderlin Christoph; Strittmatter Karin; Antoniadis Helena; Fässler Reinhard; Cavallaro Ugo; Christofori Gerhard
Increased tumor cell dissemination and cellular senescence in the absence of beta1-integrin function.
The EMBO journal 2007;26(12):2832-42.
2007: Lorenz Katrin; Grashoff Carsten; Torka Robert; Sakai Takao; Langbein Lutz; Bloch Wilhelm; Aumailley Monique; Fässler Reinhard
Integrin-linked kinase is required for epidermal and hair follicle morphogenesis.
The Journal of cell biology 2007;177(3):501-13.
2007: Fox Michael A; Sanes Joshua R; Borza Dorin-Bogdan; Eswarakumar Veraragavan P; Fässler Reinhard; Hudson Billy G; John Simon W M; Ninomiya Yoshifumi; Pedchenko Vadim; Pfaff Samuel L; Rheault Michelle N; Sado Yoshikazu; Segal Yoav; Werle Michael J; Umemori Hisashi
Distinct target-derived signals organize formation, maturation, and maintenance of motor nerve terminals.
Cell 2007;129(1):179-93.
2007: Song Lanying; Fässler Reinhard; Mishina Yuji; Jiao Kai; Baldwin H Scott
Essential functions of Alk3 during AV cushion morphogenesis in mouse embryonic hearts.
Developmental biology 2007;301(1):276-86.
2007: Montanez Eloi; Piwko-Czuchra Aleksandra; Bauer Martina; Li Shaohua; Yurchenco Peter; Fässler Reinhard
Analysis of integrin functions in peri-implantation embryos, hematopoietic system, and skin.
Methods in enzymology 2007;426():239-89.
2006: Schröder Andreas; Schröder Barbara; Roppenser Bernhard; Linder Stefan; Sinha Bhanu; Fässler Reinhard; Aepfelbacher Martin
Staphylococcus aureus fibronectin binding protein-A induces motile attachment sites and complex actin remodeling in living endothelial cells.
Molecular biology of the cell 2006;17(12):5198-210.
2006: Kvist Alexander J; Johnson Anna E; Mörgelin Matthias; Gustafsson Erika; Bengtsson Eva; Lindblom Karin; Aszódi Attila; Fässler Reinhard; Sasaki Takako; Timpl Rupert; Aspberg Anders
Chondroitin sulfate perlecan enhances collagen fibril formation. Implications for perlecan chondrodysplasias.
The Journal of biological chemistry 2006;281(44):33127-39.
2006: Sixt Michael; Bauer Martina; Lämmermann Tim; Fässler Reinhard
Beta1 integrins: zip codes and signaling relay for blood cells.
Current opinion in cell biology 2006;18(5):482-90.
2006: Ussar Siegfried; Wang Hao-Ven; Linder Stefan; Fässler Reinhard; Moser Markus
The Kindlins: subcellular localization and expression during murine development.
Experimental cell research 2006;312(16):3142-51.
2006: Czuchra Aleksandra; Meyer Hannelore; Legate Kyle R; Brakebusch Cord; Fässler Reinhard
Genetic analysis of beta1 integrin "activation motifs" in mice.
The Journal of cell biology 2006;174(6):889-99.
2006: Bungartz Gerd; Stiller Sebastian; Bauer Martina; Müller Werner; Schippers Angela; Wagner Norbert; Fässler Reinhard; Brakebusch Cord
Adult murine hematopoiesis can proceed without beta1 and beta7 integrins.
Blood 2006;108(6):1857-64.
2006: Wegmann Frank; Petri Björn; Khandoga Alexander Georg; Moser Christian; Khandoga Andrej; Volkery Stefan; Li Hang; Nasdala Ines; Brandau Oliver; Fässler Reinhard; Butz Stefan; Krombach Fritz; Vestweber Dietmar
ESAM supports neutrophil extravasation, activation of Rho, and VEGF-induced vascular permeability.
The Journal of experimental medicine 2006;203(7):1671-7.
2006: Wiesner Sebastian; Lange Anika; Fässler Reinhard
Local call: from integrins to actin assembly.
Trends in cell biology 2006;16(7):327-9.
2006: Massoumi Ramin; Chmielarska Katarzyna; Hennecke Katharina; Pfeifer Alexander; Fässler Reinhard
Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling.
Cell 2006;125(4):665-77.
2006: Ferby Ingvar; Reschke Markus; Kudlacek Oliver; Knyazev Pjotr; Pantè Guido; Amann Kerstin; Sommergruber Wolfgang; Kraut Norbert; Ullrich Axel; Fässler Reinhard; Klein Rüdiger
Mig6 is a negative regulator of EGF receptor-mediated skin morphogenesis and tumor formation.
Nature medicine 2006;12(5):568-73.
2006: Breau Marie A; Pietri Thomas; Eder Olivier; Blanche Martine; Brakebusch Cord; Fässler Reinhardt; Thiery Jean P; Dufour Sylvie
Lack of beta1 integrins in enteric neural crest cells leads to a Hirschsprung-like phenotype.
Development (Cambridge, England) 2006;133(9):1725-34.
2006: Massoumi Ramin; Podda Maurizio; Fässler Reinhard; Paus Ralf
Cylindroma as tumor of hair follicle origin.
The Journal of investigative dermatology 2006;126(5):1182-4.
2006: Bauer Richard; Humphries Martin; Fässler Reinhard; Winklmeier Andreas; Craig Sue E; Bosserhoff Anja-Katrin
Regulation of integrin activity by MIA.
The Journal of biological chemistry 2006;281(17):11669-77.
2006: Nilsson Stina; Kaniowska Dorota; Brakebusch Cord; Fässler Reinhard; Johansson Staffan
Threonine 788 in integrin subunit beta1 regulates integrin activation.
Experimental cell research 2006;312(6):844-53.
2006: Nikolova Ganka; Jabs Normund; Konstantinova Irena; Domogatskaya Anna; Tryggvason Karl; Sorokin Lydia; Fässler Reinhard; Gu Guoqiang; Gerber Hans-Peter; Ferrara Napoleone; Melton Douglas A; Lammert Eckhard
The vascular basement membrane: a niche for insulin gene expression and Beta cell proliferation.
Developmental cell 2006;10(3):397-405.
2006: Chu Haiyan; Thievessen Ingo; Sixt Michael; Lämmermann Tim; Waisman Ari; Braun Attila; Noegel Angelika A; Fässler Reinhard
gamma-Parvin is dispensable for hematopoiesis, leukocyte trafficking, and T-cell-dependent antibody response.
Molecular and cellular biology 2006;26(5):1817-25.
2006: Ruotsalainen Heli; Sipilä Laura; Vapola Miia; Sormunen Raija; Salo Antti M; Uitto Lahja; Mercer Derry K; Robins Simon P; Risteli Maija; Aszodi Attila; Fässler Reinhard; Myllylä Raili
Glycosylation catalyzed by lysyl hydroxylase 3 is essential for basement membranes.
Journal of cell science 2006;119(Pt 4):625-35.
2006: Legate Kyle R; Montañez Eloi; Kudlacek Oliver; Fässler Reinhard
ILK, PINCH and parvin: the tIPP of integrin signalling.
Nature reviews. Molecular cell biology 2006;7(1):20-31.
2006: Goto Mizuki; Sumiyoshi Hideaki; Sakai Takao; Fässler Reinhard; Ohashi Shihoka; Adachi Eijiro; Yoshioka Hidekatsu; Fujiwara Sakuhei
Elimination of epiplakin by gene targeting results in acceleration of keratinocyte migration in mice.
Molecular and cellular biology 2006;26(2):548-58.
2006: Aszódi A; Legate Kyle R; Nakchbandi I; Fässler R
What mouse mutants teach us about extracellular matrix function.
Annual review of cell and developmental biology 2006;22():591-621.
2005: Andressen Christian; Adrian Stefanie; Fässler Reinhard; Arnhold Stefan; Addicks Klaus
The contribution of beta1 integrins to neuronal migration and differentiation depends on extracellular matrix molecules.
European journal of cell biology 2005;84(12):973-82.
2005: Stanchi Fabio; Bordoy Randi; Kudlacek Oliver; Braun Attila; Pfeifer Alexander; Moser Markus; Fässler Reinhard
Consequences of loss of PINCH2 expression in mice.
Journal of cell science 2005;118(Pt 24):5899-910.
2005: Fontana Laura; Chen Yan; Prijatelj Petra; Sakai Takao; Fässler Reinhard; Sakai Lynn Y; Rifkin Daniel B
Fibronectin is required for integrin alphavbeta6-mediated activation of latent TGF-beta complexes containing LTBP-1.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(13):1798-808.
2005: Thodeti Charles Kumar; Fröhlich Camilla; Nielsen Christian Kamp; Takada Yoshikazu; Fässler Reinhard; Albrechtsen Reidar; Wewer Ulla M
ADAM12-mediated focal adhesion formation is differently regulated by beta1 and beta3 integrins.
FEBS letters 2005;579(25):5589-95.
2005: Brakebusch C; Fässler R
beta 1 integrin function in vivo: adhesion, migration and more.
Cancer metastasis reviews 2005;24(3):403-11.
2005: Li Shaohua; Bordoy Randi; Stanchi Fabio; Moser Markus; Braun Attila; Kudlacek Oliver; Wewer Ulla M; Yurchenco Peter D; Fässler Reinhard
PINCH1 regulates cell-matrix and cell-cell adhesions, cell polarity and cell survival during the peri-implantation stage.
Journal of cell science 2005;118(Pt 13):2913-21.
2005: Leone Dino P; Relvas João B; Campos Lia S; Hemmi Silvio; Brakebusch Cord; Fässler Reinhard; Ffrench-Constant Charles; Suter Ueli
Regulation of neural progenitor proliferation and survival by beta1 integrins.
Journal of cell science 2005;118(Pt 12):2589-99.
2005: Marsal Jan; Brakebusch Cord; Bungartz Gerd; Fässler Reinhard; Agace William W
beta1 integrins are not required for the maintenance of lymphocytes within intestinal epithelia.
European journal of immunology 2005;35(6):1805-11.
2005: Bengtsson Therese; Aszodi Attila; Nicolae Claudia; Hunziker Ernst B; Lundgren-Akerlund Evy; Fässler Reinhard
Loss of alpha10beta1 integrin expression leads to moderate dysfunction of growth plate chondrocytes.
Journal of cell science 2005;118(Pt 5):929-36.
2005: Suzuki Nobuyoshi; Asamura Kenji; Kikuchi Yasutake; Takumi Yutaka; Abe Satoko; Imamura Yasutada; Hayashi Toshihiko; Aszodi Attila; Fässler Reinhard; Usami Shin-ichi
Type IX collagen knock-out mouse shows progressive hearing loss.
Neuroscience research 2005;51(3):293-8.
2005: Docheva Denitsa; Hunziker Ernst B; Fässler Reinhard; Brandau Oliver
Tenomodulin is necessary for tenocyte proliferation and tendon maturation.
Molecular and cellular biology 2005;25(2):699-705.
2005: Asamura K; Abe S; Imamura Y; Aszodi A; Suzuki N; Hashimoto S; Takumi Y; Hayashi T; Fässler R; Nakamura Y; Usami S
Type IX collagen is crucial for normal hearing.
Neuroscience 2005;132(2):493-500.
2004: Kikkawa Yamato; Yu Hao; Genersch Elke; Sanzen Noriko; Sekiguchi Kiyotoshi; Fässler Reinhard; Campbell Kevin P; Talts Jan F; Ekblom Peter
Laminin isoforms differentially regulate adhesion, spreading, proliferation, and ERK activation of beta1 integrin-null cells.
Experimental cell research 2004;300(1):94-108.
2004: Grashoff Carsten; Thievessen Ingo; Lorenz Katrin; Ussar Siegfried; Fässler Reinhard
Integrin-linked kinase: integrin's mysterious partner.
Current opinion in cell biology 2004;16(5):565-71.
2004: Pietri Thomas; Eder Olivier; Breau Marie Anne; Topilko Piotr; Blanche Martine; Brakebusch Cord; Fässler Reinhard; Thiery Jean-Paul; Dufour Sylvie
Conditional beta1-integrin gene deletion in neural crest cells causes severe developmental alterations of the peripheral nervous system.
Development (Cambridge, England) 2004;131(16):3871-83.
2004: Campos Lia S; Leone Dino P; Relvas Joao B; Brakebusch Cord; Fässler Reinhard; Suter Ueli; ffrench-Constant Charles
Beta1 integrins activate a MAPK signalling pathway in neural stem cells that contributes to their maintenance.
Development (Cambridge, England) 2004;131(14):3433-44.
2004: Herzog Christine; Has Cristina; Franzke Claus-Werner; Echtermeyer Frank G; Schlötzer-Schrehardt Ursula; Kröger Stephan; Gustafsson Erika; Fässler Reinhard; Bruckner-Tuderman Leena
Dystroglycan in skin and cutaneous cells: beta-subunit is shed from the cell surface.
The Journal of investigative dermatology 2004;122(6):1372-80.
2004: Nyberg Patrik; Sakai Takao; Cho Kyu Hong; Caparon Michael G; Fässler Reinhard; Björck Lars
Interactions with fibronectin attenuate the virulence of Streptococcus pyogenes.
The EMBO journal 2004;23(10):2166-74.
2004: Bjarnegård Mattias; Enge Maria; Norlin Jenny; Gustafsdottir Sigrun; Fredriksson Simon; Abramsson Alexandra; Takemoto Minoru; Gustafsson Erika; Fässler Reinhard; Betsholtz Christer
Endothelium-specific ablation of PDGFB leads to pericyte loss and glomerular, cardiac and placental abnormalities.
Development (Cambridge, England) 2004;131(8):1847-57.
2004: Sasaki Takako; Fässler Reinhard; Hohenester Erhard
Laminin: the crux of basement membrane assembly.
The Journal of cell biology 2004;164(7):959-63.
2004: Bonnevier Johan; Fässler Reinhard; Somlyo Andrew P; Somlyo Avril V; Arner Anders
Modulation of Ca2+ sensitivity by cyclic nucleotides in smooth muscle from protein kinase G-deficient mice.
The Journal of biological chemistry 2004;279(7):5146-51.
2004: Fässler Reinhard
Lentiviral transgene vectors.
EMBO reports 2004;5(1):28-9.
2003: Aszodi Attila; Hunziker Ernst B; Brakebusch Cord; Fässler Reinhard
Beta1 integrins regulate chondrocyte rotation, G1 progression, and cytokinesis.
Genes & development 2003;17(19):2465-79.
2003: Bekku Yoko; Su Wei-Dong; Hirakawa Satoshi; Fässler Reinhard; Ohtsuka Aiji; Kang Jeong Suk; Sanders Jennifer; Murakami Takuro; Ninomiya Yoshifumi; Oohashi Toshitaka
Molecular cloning of Bral2, a novel brain-specific link protein, and immunohistochemical colocalization with brevican in perineuronal nets.
Molecular and cellular neurosciences 2003;24(1):148-59.
2003: Zhou Xiao-Hong; Brandau Oliver; Feng Kang; Oohashi Toshitaka; Ninomiya Yoshifumi; Rauch Uwe; Fässler Reinhard
The murine Ten-m/Odz genes show distinct but overlapping expression patterns during development and in adult brain.
Gene expression patterns : GEP 2003;3(4):397-405.
2003: Steiling Heike; Wüstefeld Torsten; Bugnon Philippe; Brauchle Maria; Fässler Reinhard; Teupser Daniel; Thiery Joachim; Gordon Jeffrey I; Trautwein Christian; Werner Sabine
Fibroblast growth factor receptor signalling is crucial for liver homeostasis and regeneration.
Oncogene 2003;22(28):4380-8.
2003: Brakebusch Cord; Fässler Reinhard
The integrin-actin connection, an eternal love affair.
The EMBO journal 2003;22(10):2324-33.
2003: Li Shaohua; Edgar David; Fässler Reinhard; Wadsworth William; Yurchenco Peter D
The role of laminin in embryonic cell polarization and tissue organization.
Developmental cell 2003;4(5):613-24.
2003: Grashoff Carsten; Aszódi Attila; Sakai Takao; Hunziker Ernst B; Fässler Reinhard
Integrin-linked kinase regulates chondrocyte shape and proliferation.
EMBO reports 2003;4(4):432-8.
2003: Sakai Takao; Li Shaohua; Docheva Denitsa; Grashoff Carsten; Sakai Keiko; Kostka Günter; Braun Attila; Pfeifer Alexander; Yurchenco Peter D; Fässler Reinhard
Integrin-linked kinase (ILK) is required for polarizing the epiblast, cell adhesion, and controlling actin accumulation.
Genes & development 2003;17(7):926-40.
2003: Braun Attila; Bordoy Randi; Stanchi Fabio; Moser Markus; Kostka G Günter; Ehler Elisabeth; Brandau Oliver; Fässler Reinhard
PINCH2 is a new five LIM domain protein, homologous to PINCHand localized to focal adhesions.
Experimental cell research 2003;284(2):239-50.
2003: Kuijpers Marijke J E; Schulte Valerie; Bergmeier Wolfgang; Lindhout Theo; Brakebusch Cord; Offermanns Stefan; Fässler Reinhard; Heemskerk Johan W M; Nieswandt Bernhard
Complementary roles of glycoprotein VI and alpha2beta1 integrin in collagen-induced thrombus formation in flowing whole blood ex vivo.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(6):685-7.
2003: Altrock Wilko D; tom Dieck Susanne; Sokolov Maxim; Meyer Alexander C; Sigler Albrecht; Brakebusch Cord; Fässler Reinhard; Richter Karin; Boeckers Tobias M; Potschka Heidrun; Brandt Claudia; Löscher Wolfgang; Grimberg Dörte; Dresbach Thomas; Hempelmann Anne; Hassan Hadir; Balschun Detlef; Frey Julietta U; Brandstätter Johann H; Garner Craig C; Rosenmund Christian; Gundelfinger Eckart D
Functional inactivation of a fraction of excitatory synapses in mice deficient for the active zone protein bassoon.
Neuron 2003;37(5):787-800.
2003: Ni Heyu; Yuen Peter S T; Papalia Jessie M; Trevithick Jane E; Sakai Takao; Fässler Reinhard; Hynes Richard O; Wagner Denisa D
Plasma fibronectin promotes thrombus growth and stability in injured arterioles.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(5):2415-9.
2003: He Zhi-Yong; Brakebusch Cord; Fässler Reinhard; Kreidberg Jordan A; Primakoff Paul; Myles Diana G
None of the integrins known to be present on the mouse egg or to be ADAM receptors are essential for sperm-egg binding and fusion.
Developmental biology 2003;254(2):226-37.
2003: Hoffman Laura M; Nix David A; Benson Beverly; Boot-Hanford Ray; Gustafsson Erika; Jamora Colin; Menzies A Sheila; Goh Keow Lin; Jensen Christopher C; Gertler Frank B; Fuchs Elaine; Fässler Reinhard; Beckerle Mary C
Targeted disruption of the murine zyxin gene.
Molecular and cellular biology 2003;23(1):70-9.
2002: Brakebusch Cord; Seidenbecher Constanze I; Asztely Fredrik; Rauch Uwe; Matthies Henry; Meyer Hannelore; Krug Manfred; Böckers Tobias M; Zhou Xiaohong; Kreutz Michael R; Montag Dirk; Gundelfinger Eckart D; Fässler Reinhard
Brevican-deficient mice display impaired hippocampal CA1 long-term potentiation but show no obvious deficits in learning and memory.
Molecular and cellular biology 2002;22(21):7417-27.
2002: Brandau Oliver; Aszódi Attila; Hunziker Ernst B; Neame Peter J; Vestweber Dietmar; Fässler Reinhard
Chondromodulin I is dispensable during enchondral ossification and eye development.
Molecular and cellular biology 2002;22(18):6627-35.
2002: Enge Maria; Bjarnegård Mattias; Gerhardt Holger; Gustafsson Erika; Kalén Mattias; Asker Noomi; Hammes Hans-Peter; Shani Moshe; Fässler Reinhardt; Betsholtz Christer
Endothelium-specific platelet-derived growth factor-B ablation mimics diabetic retinopathy.
The EMBO journal 2002;21(16):4307-16.
2002: Costell Mercedes; Carmona Rita; Gustafsson Erika; González-Iriarte Mauricio; Fässler Reinhard; Muñoz-Chápuli Ramón
Hyperplastic conotruncal endocardial cushions and transposition of great arteries in perlecan-null mice.
Circulation research 2002;91(2):158-64.
2002: Gustavsson Anna; Armulik Annika; Brakebusch Cord; Fässler Reinhard; Johansson Staffan; Fällman Maria
Role of the beta1-integrin cytoplasmic tail in mediating invasin-promoted internalization of Yersinia.
Journal of cell science 2002;115(Pt 13):2669-78.
2002: Feng Kang; Zhou Xiao-Hong; Oohashi Toshitaka; Mörgelin Matthias; Lustig Ariel; Hirakawa Satoshi; Ninomiya Yoshifumi; Engel Jürgen; Rauch Uwe; Fässler Reinhard
All four members of the Ten-m/Odz family of transmembrane proteins form dimers.
The Journal of biological chemistry 2002;277(29):26128-35.
2002: Svensson Liz; Aszódi Attila; Heinegård Dick; Hunziker Ernst B; Reinholt Finn P; Fässler Reinhard; Oldberg Ake
Cartilage oligomeric matrix protein-deficient mice have normal skeletal development.
Molecular and cellular biology 2002;22(12):4366-71.
2002: Grose Richard; Hutter Caroline; Bloch Wilhelm; Thorey Irmgard; Watt Fiona M; Fässler Reinhard; Brakebusch Cord; Werner Sabine
A crucial role of beta 1 integrins for keratinocyte migration in vitro and during cutaneous wound repair.
Development (Cambridge, England) 2002;129(9):2303-15.
2002: Hirsch Emilio; Barberis Laura; Brancaccio Mara; Azzolino Ornella; Xu Dazhong; Kyriakis John M; Silengo Lorenzo; Giancotti Filippo G; Tarone Guido; Fässler Reinhard; Altruda Fiorella
Defective Rac-mediated proliferation and survival after targeted mutation of the beta1 integrin cytodomain.
The Journal of cell biology 2002;157(3):481-92.
2002: Brakebusch Cord; Bouvard Daniel; Stanchi Fabio; Sakai Takao; Fässler Reinhard
Integrins in invasive growth.
The Journal of clinical investigation 2002;109(8):999-1006.
2002: Brakebusch Cord; Fillatreau Simon; Potocnik Alexandre J; Bungartz Gerd; Wilhelm Patricia; Svensson Marcus; Kearney Phil; Körner Heinrich; Gray David; Fässler Reinhard
Beta1 integrin is not essential for hematopoiesis but is necessary for the T cell-dependent IgM antibody response.
Immunity 2002;16(3):465-77.
2002: Moser Markus; Bosserhoff Anja-Katrin; Hunziker Ernst B; Sandell Linda; Fässler Reinhard; Buettner Reinhard
Ultrastructural cartilage abnormalities in MIA/CD-RAP-deficient mice.
Molecular and cellular biology 2002;22(5):1438-45.
2002: Braun Attila; Aszódi Attila; Hellebrand Heide; Berna Alejandro; Fässler Reinhard; Brandau Oliver
Genomic organization of profilin-III and evidence for a transcript expressed exclusively in testis.
Gene 2002;283(1-2):219-25.
2001: Sasaki T; Göhring W; Mann K; Brakebusch C; Yamada Y; Fässler R; Timpl R
Short arm region of laminin-5 gamma2 chain: structure, mechanism of processing and binding to heparin and proteins.
Journal of molecular biology 2001;314(4):751-63.
2001: Kostka G; Giltay R; Bloch W; Addicks K; Timpl R; Fässler R; Chu M L
Perinatal lethality and endothelial cell abnormalities in several vessel compartments of fibulin-1-deficient mice.
Molecular and cellular biology 2001;21(20):7025-34.
2001: Zhou X H; Brakebusch C; Matthies H; Oohashi T; Hirsch E; Moser M; Krug M; Seidenbecher C I; Boeckers T M; Rauch U; Buettner R; Gundelfinger E D; Fässler R
Neurocan is dispensable for brain development.
Molecular and cellular biology 2001;21(17):5970-8.
2001: Bloch W; Fan Y; Han J; Xue S; Schöneberg T; Ji G; Lu Z J; Walther M; Fässler R; Hescheler J; Addicks K; Fleischmann B K
Disruption of cytoskeletal integrity impairs Gi-mediated signaling due to displacement of Gi proteins.
The Journal of cell biology 2001;154(4):753-61.
2001: Bouvard D; Brakebusch C; Gustafsson E; Aszódi A; Bengtsson T; Berna A; Fässler R
Functional consequences of integrin gene mutations in mice.
Circulation research 2001;89(3):211-23.
2001: Herr C; Smyth N; Ullrich S; Yun F; Sasse P; Hescheler J; Fleischmann B; Lasek K; Brixius K; Schwinger R H; Fässler R; Schröder R; Noegel A A
Loss of annexin A7 leads to alterations in frequency-induced shortening of isolated murine cardiomyocytes.
Molecular and cellular biology 2001;21(13):4119-28.
2001: Bergmeier W; Bouvard D; Eble J A; Mokhtari-Nejad R; Schulte V; Zirngibl H; Brakebusch C; Fässler R; Nieswandt B
Rhodocytin (aggretin) activates platelets lacking alpha(2)beta(1) integrin, glycoprotein VI, and the ligand-binding domain of glycoprotein Ibalpha.
The Journal of biological chemistry 2001;276(27):25121-6.
2001: Brandau O; Meindl A; Fässler R; Aszódi A
A novel gene, tendin, is strongly expressed in tendons and ligaments and shows high homology with chondromodulin-I.
Developmental dynamics : an official publication of the American Association of Anatomists 2001;221(1):72-80.
2001: Nieswandt B; Brakebusch C; Bergmeier W; Schulte V; Bouvard D; Mokhtari-Nejad R; Lindhout T; Heemskerk J W; Zirngibl H; Fässler R
Glycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagen.
The EMBO journal 2001;20(9):2120-30.
2001: Sakai T; Johnson K J; Murozono M; Sakai K; Magnuson M A; Wieloch T; Cronberg T; Isshiki A; Erickson H P; Fässler R
Plasma fibronectin supports neuronal survival and reduces brain injury following transient focal cerebral ischemia but is not essential for skin-wound healing and hemostasis.
Nature medicine 2001;7(3):324-30.
2001: Henry M D; Satz J S; Brakebusch C; Costell M; Gustafsson E; Fässler R; Campbell K P
Distinct roles for dystroglycan, beta1 integrin and perlecan in cell surface laminin organization.
Journal of cell science 2001;114(Pt 6):1137-44.
2001: Gustafsson E; Brakebusch C; Hietanen K; Fässler R
Tie-1-directed expression of Cre recombinase in endothelial cells of embryoid bodies and transgenic mice.
Journal of cell science 2001;114(Pt 4):671-6.
2001: Sakai K; Hiripi L; Glumoff V; Brandau O; Eerola R; Vuorio E; Bösze Z; Fässler R; Aszódi A
Stage-and tissue-specific expression of a Col2a1-Cre fusion gene in transgenic mice.
Matrix biology : journal of the International Society for Matrix Biology 2001;19(8):761-7.
2001: Aszódi A; Hunziker E B; Olsen B R; Fässler R
The role of collagen II and cartilage fibril-associated molecules in skeletal development.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2001;9 Suppl A():S150-9.
2000: Gustafsson E; Fässler R
Insights into extracellular matrix functions from mutant mouse models.
Experimental cell research 2000;261(1):52-68.
2000: Brakebusch C; Grose R; Quondamatteo F; Ramirez A; Jorcano J L; Pirro A; Svensson M; Herken R; Sasaki T; Timpl R; Werner S; Fässler R
Skin and hair follicle integrity is crucially dependent on beta 1 integrin expression on keratinocytes.
The EMBO journal 2000;19(15):3990-4003.
2000: Wennerberg K; Armulik A; Sakai T; Karlsson M; Fässler R; Schaefer E M; Mosher D F; Johansson S
The cytoplasmic tyrosines of integrin subunit beta1 are involved in focal adhesion kinase activation.
Molecular and cellular biology 2000;20(15):5758-65.
2000: Potocnik A J; Brakebusch C; Fässler R
Fetal and adult hematopoietic stem cells require beta1 integrin function for colonizing fetal liver, spleen, and bone marrow.
Immunity 2000;12(6):653-63.
2000: Bear J E; Loureiro J J; Libova I; Fässler R; Wehland J; Gertler F B
Negative regulation of fibroblast motility by Ena/VASP proteins.
Cell 2000;101(7):717-28.
2000: Iba K; Albrechtsen R; Gilpin B; Fröhlich C; Loechel F; Zolkiewska A; Ishiguro K; Kojima T; Liu W; Langford J K; Sanderson R D; Brakebusch C; Fässler R; Wewer U M
The cysteine-rich domain of human ADAM 12 supports cell adhesion through syndecans and triggers signaling events that lead to beta1 integrin-dependent cell spreading.
The Journal of cell biology 2000;149(5):1143-56.
2000: Aszódi A; Bateman J F; Gustafsson E; Boot-Handford R; Fässler R
Mammalian skeletogenesis and extracellular matrix: what can we learn from knockout mice?
Cell structure and function 2000;25(2):73-84.
2000: Hirsch E; Oohashi T; Ahmad M; Stamm S; Fässler R
Peri-implantation lethality in mice lacking the Sm motif-containing protein Lsm4.
Molecular and cellular biology 2000;20(3):1055-62.
2000: Ny L; Pfeifer A; Aszòdi A; Ahmad M; Alm P; Hedlund P; Fässler R; Andersson K E
Impaired relaxation of stomach smooth muscle in mice lacking cyclic GMP-dependent protein kinase I.
British journal of pharmacology 2000;129(2):395-401.
2000: Aumailley M; Pesch M; Tunggal L; Gaill F; Fässler R
Altered synthesis of laminin 1 and absence of basement membrane component deposition in (beta)1 integrin-deficient embryoid bodies.
Journal of cell science 2000;113 Pt 2():259-68.
2000: Armulik A; Svineng G; Wennerberg K; Fässler R; Johansson S
Expression of integrin subunit beta1B in integrin beta1-deficient GD25 cells does not interfere with alphaVbeta3 functions.
Experimental cell research 2000;254(1):55-63.
1999: Costell M; Gustafsson E; Aszódi A; Mörgelin M; Bloch W; Hunziker E; Addicks K; Timpl R; Fässler R
Perlecan maintains the integrity of cartilage and some basement membranes.
The Journal of cell biology 1999;147(5):1109-22.
1999: Aszódi A; Bateman J F; Hirsch E; Baranyi M; Hunziker E B; Hauser N; Bösze Z; Fässler R
Normal skeletal development of mice lacking matrilin 1: redundant function of matrilins in cartilage?
Molecular and cellular biology 1999;19(11):7841-5.
1999: Brakebusch C; Wennerberg K; Krell H W; Weidle U H; Sallmyr A; Johansson S; Fässler R
Beta1 integrin promotes but is not essential for metastasis of ras-myc transformed fibroblasts.
Oncogene 1999;18(26):3852-61.
1999: Talts J F; Wirl G; Dictor M; Muller W J; Fässler R
Tenascin-C modulates tumor stroma and monocyte/macrophage recruitment but not tumor growth or metastasis in a mouse strain with spontaneous mammary cancer.
Journal of cell science 1999;112 ( Pt 12)():1855-64.
1999: Oohashi T; Zhou X H; Feng K; Richter B; Mörgelin M; Perez M T; Su W D; Chiquet-Ehrismann R; Rauch U; Fässler R
Mouse ten-m/Odz is a new family of dimeric type II transmembrane proteins expressed in many tissues.
The Journal of cell biology 1999;145(3):563-77.
1999: Massberg S; Sausbier M; Klatt P; Bauer M; Pfeifer A; Siess W; Fässler R; Ruth P; Krombach F; Hofmann F
Increased adhesion and aggregation of platelets lacking cyclic guanosine 3',5'-monophosphate kinase I.
The Journal of experimental medicine 1999;189(8):1255-64.
1999: Svensson L; Aszódi A; Reinholt F P; Fässler R; Heinegård D; Oldberg A
Fibromodulin-null mice have abnormal collagen fibrils, tissue organization, and altered lumican deposition in tendon.
The Journal of biological chemistry 1999;274(14):9636-47.
1999: Aszódi A; Pfeifer A; Ahmad M; Glauner M; Zhou X H; Ny L; Andersson K E; Kehrel B; Offermanns S; Fässler R
The vasodilator-stimulated phosphoprotein (VASP) is involved in cGMP- and cAMP-mediated inhibition of agonist-induced platelet aggregation, but is dispensable for smooth muscle function.
The EMBO journal 1999;18(1):37-48.
1999: Kleppisch T; Pfeifer A; Klatt P; Ruth P; Montkowski A; Fässler R; Hofmann F
Long-term potentiation in the hippocampal CA1 region of mice lacking cGMP-dependent kinases is normal and susceptible to inhibition of nitric oxide synthase.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(1):48-55.
1999: Talts J F; Brakebusch C; Fässler R
Integrin gene targeting.
Methods in molecular biology (Clifton, N.J.) 1999;129():153-87.
1998: Aszódi A; Chan D; Hunziker E; Bateman J F; Fässler R
Collagen II is essential for the removal of the notochord and the formation of intervertebral discs.
The Journal of cell biology 1998;143(5):1399-412.
1998: Talts J F; Pfeifer A; Hofmann F; Hunziker E B; Zhou X H; Aszódi A; Fässler R
Endochondral ossification is dependent on the mechanical properties of cartilage tissue and on intracellular signals in chondrocytes.
Annals of the New York Academy of Sciences 1998;857():74-85.
1998: Hirsch E; Lohikangas L; Gullberg D; Johansson S; Fässler R
Mouse myoblasts can fuse and form a normal sarcomere in the absence of beta1 integrin expression.
Journal of cell science 1998;111 ( Pt 16)():2397-409.
1998: Andressen C; Arnhold S; Puschmann M; Bloch W; Hescheler J; Fässler R; Addicks K
Beta1 integrin deficiency impairs migration and differentiation of mouse embryonic stem cell derived neurons.
Neuroscience letters 1998;251(3):165-8.
1998: Litzenburger T; Fässler R; Bauer J; Lassmann H; Linington C; Wekerle H; Iglesias A
B lymphocytes producing demyelinating autoantibodies: development and function in gene-targeted transgenic mice.
The Journal of experimental medicine 1998;188(1):169-80.
1998: Pfeifer A; Klatt P; Massberg S; Ny L; Sausbier M; Hirneiss C; Wang G X; Korth M; Aszódi A; Andersson K E; Krombach F; Mayerhofer A; Ruth P; Fässler R; Hofmann F
Defective smooth muscle regulation in cGMP kinase I-deficient mice.
The EMBO journal 1998;17(11):3045-51.
1998: Retta S F; Balzac F; Ferraris P; Belkin A M; Fässler R; Humphries M J; De Leo G; Silengo L; Tarone G
beta1-integrin cytoplasmic subdomains involved in dominant negative function.
Molecular biology of the cell 1998;9(4):715-31.
1998: Wennerberg K; Fässler R; Wärmegård B; Johansson S
Mutational analysis of the potential phosphorylation sites in the cytoplasmic domain of integrin beta1A. Requirement for threonines 788-789 in receptor activation.
Journal of cell science 1998;111 ( Pt 8)():1117-26.
1998: Aszódi A; Beier D R; Hiripi L; Bösze Z; Fässler R
Sequence, structure and chromosomal localization of Crtm gene encoding mouse cartilage matrix protein and its exclusion as a candidate for murine achondroplasia.
Matrix biology : journal of the International Society for Matrix Biology 1998;16(9):563-73.
1998: Svineng G; Fässler R; Johansson S
Identification of beta1C-2, a novel variant of the integrin beta1 subunit generated by utilization of an alternative splice acceptor site in exon C.
The Biochemical journal 1998;330 ( Pt 3)():1255-63.
1998: Sasaki T; Forsberg E; Bloch W; Addicks K; Fässler R; Timpl R
Deficiency of beta 1 integrins in teratoma interferes with basement membrane assembly and laminin-1 expression.
Experimental cell research 1998;238(1):70-81.
1997: Brakebusch C; Hirsch E; Potocnik A; Fässler R
Genetic analysis of beta1 integrin function: confirmed, new and revised roles for a crucial family of cell adhesion molecules.
Journal of cell science 1997;110 ( Pt 23)():2895-904.
1997: Mayer U; Saher G; Fässler R; Bornemann A; Echtermeyer F; von der Mark H; Miosge N; Pöschl E; von der Mark K
Absence of integrin alpha 7 causes a novel form of muscular dystrophy.
Nature genetics 1997;17(3):318-23.
1997: Rauch U; Clement A; Retzler C; Fröhlich L; Fässler R; Göhring W; Faissner A
Mapping of a defined neurocan binding site to distinct domains of tenascin-C.
The Journal of biological chemistry 1997;272(43):26905-12.
1997: Bloch W; Forsberg E; Lentini S; Brakebusch C; Martin K; Krell H W; Weidle U H; Addicks K; Fässler R
Beta 1 integrin is essential for teratoma growth and angiogenesis.
The Journal of cell biology 1997;139(1):265-78.
1997: Rauch U; Meyer H; Brakebusch C; Seidenbecher C; Gundelfinger E D; Beier D R; Fässler R
Sequence and chromosomal localization of the mouse brevican gene.
Genomics 1997;44(1):15-21.
1997: Moser M; Pscherer A; Roth C; Becker J; Mücher G; Zerres K; Dixkens C; Weis J; Guay-Woodford L; Buettner R; Fässler R
Enhanced apoptotic cell death of renal epithelial cells in mice lacking transcription factor AP-2beta.
Genes & development 1997;11(15):1938-48.
1997: Hagg R; Hedbom E; Möllers U; Aszódi A; Fässler R; Bruckner P
Absence of the alpha1(IX) chain leads to a functional knock-out of the entire collagen IX protein in mice.
The Journal of biological chemistry 1997;272(33):20650-4.
1996: Fässler R; Rohwedel J; Maltsev V; Bloch W; Lentini S; Guan K; Gullberg D; Hescheler J; Addicks K; Wobus A M
Differentiation and integrity of cardiac muscle cells are impaired in the absence of beta 1 integrin.
Journal of cell science 1996;109 ( Pt 13)():2989-99.
1996: Pfeifer A; Aszódi A; Seidler U; Ruth P; Hofmann F; Fässler R
Intestinal secretory defects and dwarfism in mice lacking cGMP-dependent protein kinase II.
Science (New York, N.Y.) 1996;274(5295):2082-6.
1996: Bagutti C; Wobus A M; Fässler R; Watt F M
Differentiation of embryonal stem cells into keratinocytes: comparison of wild-type and beta 1 integrin-deficient cells.
Developmental biology 1996;179(1):184-96.
1996: Forsberg E; Hirsch E; Fröhlich L; Meyer M; Ekblom P; Aszodi A; Werner S; Fässler R
Skin wounds and severed nerves heal normally in mice lacking tenascin-C.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(13):6594-9.
1996: Hirsch E; Iglesias A; Potocnik A J; Hartmann U; Fässler R
Impaired migration but not differentiation of haematopoietic stem cells in the absence of beta1 integrins.
Nature 1996;380(6570):171-5.
1996: Wennerberg K; Lohikangas L; Gullberg D; Pfaff M; Johansson S; Fässler R
Beta 1 integrin-dependent and -independent polymerization of fibronectin.
The Journal of cell biology 1996;132(1-2):227-38.
1996: Fässler R; Sasaki T; Timpl R; Chu M L; Werner S
Differential regulation of fibulin, tenascin-C, and nidogen expression during wound healing of normal and glucocorticoid-treated mice.
Experimental cell research 1996;222(1):111-6.
1995: Seidenbecher C I; Richter K; Rauch U; Fässler R; Garner C C; Gundelfinger E D
Brevican, a chondroitin sulfate proteoglycan of rat brain, occurs as secreted and cell surface glycosylphosphatidylinositol-anchored isoforms.
The Journal of biological chemistry 1995;270(45):27206-12.
1995: Fässler R; Meyer M
Consequences of lack of beta 1 integrin gene expression in mice.
Genes & development 1995;9(15):1896-908.
1995: Rauch U; Grimpe B; Kulbe G; Arnold-Ammer I; Beier D R; Fässler R
Structure and chromosomal localization of the mouse neurocan gene.
Genomics 1995;28(3):405-10.
1995: Wirl G; Hermann M; Ekblom P; Fässler R
Mammary epithelial cell differentiation in vitro is regulated by an interplay of EGF action and tenascin-C downregulation.
Journal of cell science 1995;108 ( Pt 6)():2445-56.
1995: Fässler R; Martin K; Forsberg E; Litzenburger T; Iglesias A
Knockout mice: how to make them and why. The immunological approach.
International archives of allergy and immunology 1995;106(4):323-34.
1995: Fässler R; Pfaff M; Murphy J; Noegel A A; Johansson S; Timpl R; Albrecht R
Lack of beta 1 integrin gene in embryonic stem cells affects morphology, adhesion, and migration but not integration into the inner cell mass of blastocysts.
The Journal of cell biology 1995;128(5):979-88.

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