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Walter Fast

Research Profile

Chemicals & Drugs

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Physiology

Quorum Sensing

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Publications

TOP 3
Pei W Thomas; Jennifer S Brodbelt; Michael Cammarata; Peter Hodder; Timothy Spicer; Walter Fast
An altered zinc-binding site confers resistance to a covalent inactivator of New Delhi metallo-beta-lactamase-1 (NDM-1) discovered by high-throughput screening.
Ce Feng Liu; Dali Liu; Jessica Momb; Gregory A Petsko; Walter Fast; Ashley Lajoie; Pei W Thomas; Dagmar Ringe
A phenylalanine clamp controls substrate specificity in the quorum-quenching metallo-γ-lactonase from Bacillus thuringiensis.
Thomas W Linsky; Walter Fast
Discovery of structurally-diverse inhibitor scaffolds by high-throughput screening of a fragment library with dimethylarginine dimethylaminohydrolase.

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All Publications

2013: Pei W Thomas; Jennifer S Brodbelt; Michael Cammarata; Peter Hodder; Timothy Spicer; Walter Fast
An altered zinc-binding site confers resistance to a covalent inactivator of New Delhi metallo-beta-lactamase-1 (NDM-1) discovered by high-throughput screening.
Bioorganic & medicinal chemistry 2013;21(11):3138-46.
2013: Ce Feng Liu; Dali Liu; Jessica Momb; Gregory A Petsko; Walter Fast; Ashley Lajoie; Pei W Thomas; Dagmar Ringe
A phenylalanine clamp controls substrate specificity in the quorum-quenching metallo-γ-lactonase from Bacillus thuringiensis.
Biochemistry 2013;52(9):1603-10.
2012: Thomas W Linsky; Walter Fast
Discovery of structurally-diverse inhibitor scaffolds by high-throughput screening of a fragment library with dimethylarginine dimethylaminohydrolase.
Bioorganic & medicinal chemistry 2012;20(18):5550-8.
2012: Kenneth D Clevenger; Walter Fast
"Clicking" on the lights to reveal bacterial social networking.
Chembiochem : a European journal of chemical biology 2012;13(4):508-10.
2012: Walter Fast; Peter A Tipton
The enzymes of bacterial census and censorship.
Trends in biochemical sciences 2012;37(1):7-14.
2011: Pei W Thomas; Shanshan Wu; Dingguo Xu; Min Zheng; Hua Guo; Dali Liu; Walter Fast
Characterization of purified New Delhi metallo-β-lactamase-1.
Biochemistry 2011;50(46):10102-13.
2011: Thomas Linsky; Walter Fast
A continuous, fluorescent, high-throughput assay for human dimethylarginine dimethylaminohydrolase-1.
Journal of biomolecular screening 2011;16(9):1089-97.
2011: Corey M Johnson; Zhihong Ke; Thomas W Linsky; Arthur F Monzingo; Jon D Robertus; Dae-Wi Yoon; Hua Guo; Walter Fast
On the mechanism of dimethylarginine dimethylaminohydrolase inactivation by 4-halopyridines.
Journal of the American Chemical Society 2011;133(28):10951-9.
2011: Qin Guo; Mark T Bedford; Walter Fast
Discovery of peptidylarginine deiminase-4 substrates by protein array: antagonistic citrullination and methylation of human ribosomal protein S2.
Molecular bioSystems 2011;7(7):2286-95.
2011: Qin Guo; Walter Fast
Citrullination of inhibitor of growth 4 (ING4) by peptidylarginine deminase 4 (PAD4) disrupts the interaction between ING4 and p53.
The Journal of biological chemistry 2011;286(19):17069-78.
2011: Corey M Johnson; Thomas W Linsky; Dae-Wi Yoon; Maria D Person; Walter Fast
Discovery of halopyridines as quiescent affinity labels: inactivation of dimethylarginine dimethylaminohydrolase.
Journal of the American Chemical Society 2011;133(5):1553-62.
2011: Matthew Lluis; Yun Wang; Arthur F Monzingo; Walter Fast; Jon D Robertus
Characterization of C-alkyl amidines as bioavailable covalent reversible inhibitors of human DDAH-1.
ChemMedChem 2011;6(1):81-8.
2011: Pei W Thomas; Walter Fast
Heterologous overexpression, purification, and in vitro characterization of AHL lactonases.
Methods in molecular biology (Clifton, N.J.) 2011;692():275-90.
2010: Thomas Linsky; Walter Fast
Mechanistic similarity and diversity among the guanidine-modifying members of the pentein superfamily.
Biochimica et biophysica acta 2010;1804(10):1943-53.
2010: Jessica Momb; Dae-Wi Yoon; Walter Fast
Enzymic disruption of N-aroyl-L-homoserine lactone-based quorum sensing.
Chembiochem : a European journal of chemical biology 2010;11(11):1535-7.
2009: Yun Wang; Shougang Hu; Walter Fast
A click chemistry mediated in vivo activity probe for dimethylarginine dimethylaminohydrolase.
Journal of the American Chemical Society 2009;131(42):15096-7.
2009: Pattraranee Limphong; George Nimako; Pei W Thomas; Walter Fast; Christopher A Makaroff; Michael W Crowder
Arabidopsis thaliana mitochondrial glyoxalase 2-1 exhibits beta-lactamase activity.
Biochemistry 2009;48(36):8491-3.
2009: Yun Wang; Arthur F Monzingo; Shougang Hu; Tera H Schaller; Jon D Robertus; Walter Fast
Developing dual and specific inhibitors of dimethylarginine dimethylaminohydrolase-1 and nitric oxide synthase: toward a targeted polypharmacology to control nitric oxide.
Biochemistry 2009;48(36):8624-35.
2009: Hui Li; Walter Fast; Stephen J Benkovic
Structural and functional modularity of proteins in the de novo purine biosynthetic pathway.
Protein science : a publication of the Protein Society 2009;18(5):881-92.
2008: Jessica Momb; Canhui Wang; Dali Liu; Pei W Thomas; Gregory A Petsko; Hua Guo; Dagmar Ringe; Walter Fast
Mechanism of the quorum-quenching lactonase (AiiA) from Bacillus thuringiensis. 2. Substrate modeling and active site mutations.
Biochemistry 2008;47(29):7715-25.
2008: Dali Liu; Jessica Momb; Pei W Thomas; Aaron Moulin; Gregory A Petsko; Walter Fast; Dagmar Ringe
Mechanism of the quorum-quenching lactonase (AiiA) from Bacillus thuringiensis. 1. Product-bound structures.
Biochemistry 2008;47(29):7706-14.
2008: Thomas W Linsky; Arthur F Monzingo; Everett Stone; Jon D Robertus; Walter Fast
Promiscuous partitioning of a covalent intermediate common in the pentein superfamily.
Chemistry & biology 2008;15(5):467-75.
2007: Lin Hong; Walter Fast
Inhibition of human dimethylarginine dimethylaminohydrolase-1 by S-nitroso-L-homocysteine and hydrogen peroxide. Analysis, quantification, and implications for hyperhomocysteinemia.
The Journal of biological chemistry 2007;282(48):34684-92.
2007: Dali Liu; Pei W Thomas; Jessica Momb; Quyen Q Hoang; Gregory A Petsko; Dagmar Ringe; Walter Fast
Structure and specificity of a quorum-quenching lactonase (AiiB) from Agrobacterium tumefaciens.
Biochemistry 2007;46(42):11789-99.
2006: Jessica Momb; Pei W Thomas; Robert M Breece; David L Tierney; Walter Fast
The quorum-quenching metallo-gamma-lactonase from Bacillus thuringiensis exhibits a leaving group thio effect.
Biochemistry 2006;45(44):13385-93.
2006: Paul R Thompson; Walter Fast
Histone citrullination by protein arginine deiminase: is arginine methylation a green light or a roadblock?
ACS chemical biology 2006;1(7):433-41.
2006: Everett Stone; Alison L Costello; David L Tierney; Walter Fast
Substrate-assisted cysteine deprotonation in the mechanism of dimethylargininase (DDAH) from Pseudomonas aeruginosa.
Biochemistry 2006;45(17):5618-30.
2005: Everett Stone; Terezie H Schaller; Helena Bianchi; Maria D Person; Walter Fast
Inactivation of two diverse enzymes in the amidinotransferase superfamily by 2-chloroacetamidine: dimethylargininase and peptidylarginine deiminase.
Biochemistry 2005;44(42):13744-52.
2005: Dali Liu; Bryan W Lepore; Gregory A Petsko; Pei W Thomas; Everett Stone; Walter Fast; Dagmar Ringe
Three-dimensional structure of the quorum-quenching N-acyl homoserine lactone hydrolase from Bacillus thuringiensis.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(33):11882-7.
2005: Everett Stone; Walter Fast
A continuous spectrophotometric assay for dimethylarginine dimethylaminohydrolase.
Analytical biochemistry 2005;343(2):335-7.
2005: Pei W Thomas; Everett Stone; Alison L Costello; David L Tierney; Walter Fast
The quorum-quenching lactonase from Bacillus thuringiensis is a metalloprotein.
Biochemistry 2005;44(20):7559-69.
2005: Everett Stone; Maria D Person; Nicholas J Costello; Walter Fast
Characterization of a transient covalent adduct formed during dimethylarginine dimethylaminohydrolase catalysis.
Biochemistry 2005;44(18):7069-78.
2003: James J A Huntley; Walter Fast; Stephen J Benkovic; Peter Wright; H Jane Dyson
Role of a solvent-exposed tryptophan in the recognition and binding of antibiotic substrates for a metallo-beta-lactamase.
Protein science : a publication of the Protein Society 2003;12(7):1368-75.
2003: Walter Fast
Molecular radio jamming: autoinducer analogs.
Chemistry & biology 2003;10(1):1-2.
2002: Stefan Lutz; Walter Fast; Stephen J Benkovic
A universal, vector-based system for nucleic acid reading-frame selection.
Protein engineering 2002;15(12):1025-30.
2001: Walter Fast; Z Wang; Stephen J Benkovic
Familial mutations and zinc stoichiometry determine the rate-limiting step of nitrocefin hydrolysis by metallo-beta-lactamase from Bacteroides fragilis.
Biochemistry 2001;40(6):1640-50.
1999: Z Wang; Walter Fast; Ann M Valentine; Stephen J Benkovic
Metallo-beta-lactamase: structure and mechanism.
Current opinion in chemical biology 1999;3(5):614-22.
1999: Z Wang; Walter Fast; Stephen J Benkovic
On the mechanism of the metallo-beta-lactamase from Bacteroides fragilis.
Biochemistry 1999;38(31):10013-23.
1997: H Q Zhang; Walter Fast; Michael A Marletta; Pavel Martasek; Richard B Silverman
Potent and selective inhibition of neuronal nitric oxide synthase by N omega-propyl-L-arginine.
Journal of medicinal chemistry 1997;40(24):3869-70.
1997: Walter Fast; M E Levsky; Michael A Marletta; Richard B Silverman
N omega-propargyl-L-arginine and N omega-hydroxy-N omega-propargyl-L-arginine are inhibitors, but not inactivators, of neuronal and macrophage nitric oxide synthases.
Bioorganic & medicinal chemistry 1997;5(8):1601-8.
1996: Lizbeth Hedstrom; T Y Lin; Walter Fast
Hydrophobic interactions control zymogen activation in the trypsin family of serine proteases.
Biochemistry 1996;35(14):4515-23.