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Szabolcs Fatrai

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Insulinoma

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Publications

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Szabolcs Fatrai; Albertus T J Wierenga; S M G J Daenen; Edo Vellenga; Jan Jacob Schuringa
Identification of HIF2alpha as an important STAT5 target gene in human hematopoietic stem cells.
Szabolcs Fatrai; Djoke van Gosliga; Lina Han; Simon M G J Daenen; Edo Vellenga; Jan Jacob Schuringa
KRAS(G12V) enhances proliferation and initiates myelomonocytic differentiation in human stem/progenitor cells via intrinsic and extrinsic pathways.
Lynda Elghazi-Cras; Norman Balcazar; Manuel Blandino-Rosano; Corentin Cras-Méneur; Szabolcs Fatrai; Aaron P Gould; Maggie M Chi; Kelle H Moley; Ernesto Bernal-Mizrachi
Decreased IRS signaling impairs beta-cell cycle progression and survival in transgenic mice overexpressing S6K in beta-cells.

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2011: Szabolcs Fatrai; Albertus T J Wierenga; S M G J Daenen; Edo Vellenga; Jan Jacob Schuringa
Identification of HIF2alpha as an important STAT5 target gene in human hematopoietic stem cells.
Blood 2011;117(12):3320-30.
2011: Szabolcs Fatrai; Djoke van Gosliga; Lina Han; Simon M G J Daenen; Edo Vellenga; Jan Jacob Schuringa
KRAS(G12V) enhances proliferation and initiates myelomonocytic differentiation in human stem/progenitor cells via intrinsic and extrinsic pathways.
The Journal of biological chemistry 2011;286(8):6061-70.
2010: Lynda Elghazi-Cras; Norman Balcazar; Manuel Blandino-Rosano; Corentin Cras-Méneur; Szabolcs Fatrai; Aaron P Gould; Maggie M Chi; Kelle H Moley; Ernesto Bernal-Mizrachi
Decreased IRS signaling impairs beta-cell cycle progression and survival in transgenic mice overexpressing S6K in beta-cells.
Diabetes 2010;59(10):2390-9.
2008: Szabolcs Fatrai; Hein Schepers; Henko Tadema; Edo Vellenga; S M G J Daenen; Jan Jacob Schuringa
Mucin1 expression is enriched in the human stem cell fraction of cord blood and is upregulated in majority of the AML cases.
Experimental hematology 2008;36(10):1254-65.
2008: Sandra G M Olthof; Szabolcs Fatrai; A Lyndsay Drayer; Monika R Tyl; Edo Vellenga; Jan Jacob Schuringa
Downregulation of signal transducer and activator of transcription 5 (STAT5) in CD34+ cells promotes megakaryocytic development, whereas activation of STAT5 drives erythropoiesis.
Stem cells (Dayton, Ohio) 2008;26(7):1732-42.
2007: Eija Pirinen; Tiina Kuulasmaa; Marko Pietilä; Sami Heikkinen; Maija Tusa; Paula Itkonen; Susanna Boman; Joanna Skommer; Antti Virkamäki; Esa Hohtola; Mikko I Kettunen; Szabolcs Fatrai; Emilia Kansanen; Suvi Koota; Kirsi Niiranen; Jyrki Parkkinen; Anna-Liisa Levonen; Seppo Ylä-Herttuala; J Kalervo Hiltunen; Leena Alhonen; Ulf Smith; Juhani Jänne; Markku Laakso
Enhanced polyamine catabolism alters homeostatic control of white adipose tissue mass, energy expenditure, and glucose metabolism.
Molecular and cellular biology 2007;27(13):4953-67.
2006: Kirsi Niiranen; Tuomo A Keinänen; Eija Pirinen; Sami Heikkinen; Maija Tusa; Szabolcs Fatrai; Suvikki Suppola; Marko Pietilä; Anne Uimari; Markku Laakso; Leena Alhonen; Juhani Jänne
Mice with targeted disruption of spermidine/spermine N1-acetyltransferase gene maintain nearly normal tissue polyamine homeostasis but show signs of insulin resistance upon aging.
Journal of cellular and molecular medicine 2006;10(4):933-45.
2006: Szabolcs Fatrai; Lynda Elghazi-Cras; Norman Balcazar; Corentin Cras-Méneur; Irina Krits; Hiroaki Kiyokawa; Ernesto Bernal-Mizrachi
Akt induces beta-cell proliferation by regulating cyclin D1, cyclin D2, and p21 levels and cyclin-dependent kinase-4 activity.
Diabetes 2006;55(2):318-25.
2005: A C Riggs; Ernesto Bernal-Mizrachi; Mitsuru Ohsugi; JC Wasson; Szabolcs Fatrai; CM Welling; J Murray; R E Schmidt; P L Herrera; M Alan Permutt
Mice conditionally lacking the Wolfram gene in pancreatic islet beta cells exhibit diabetes as a result of enhanced endoplasmic reticulum stress and apoptosis.
Diabetologia 2005;48(11):2313-21.
2005: Shanthi Srinivasan; Mitsuru Ohsugi; Zhonghao Liu; Szabolcs Fatrai; Ernesto Bernal-Mizrachi; M Alan Permutt
Endoplasmic reticulum stress-induced apoptosis is partly mediated by reduced insulin signaling through phosphatidylinositol 3-kinase/Akt and increased glycogen synthase kinase-3beta in mouse insulinoma cells.
Diabetes 2005;54(4):968-75.
2004: Ernesto Bernal-Mizrachi; Szabolcs Fatrai; James D Johnson; Mitsuru Ohsugi; Kenichi Otani; Zhiqiang Han; Kenneth S Polonsky; M Alan Permutt
Defective insulin secretion and increased susceptibility to experimental diabetes are induced by reduced Akt activity in pancreatic islet beta cells.
The Journal of clinical investigation 2004;114(7):928-36.