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Ladan Fazli

Research Profile

Disorders

Anatomy

Tumor Cell Line

Living Beings

Chemicals & Drugs

Procedures

Physiology

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Publications

TOP 3
Masaki Shiota; Ario Takeuchi; Anousheh Zardan; Jenny Bazov; Eliana Beraldi; Jennifer L Bishop; Kim Chi; Thomas Cordonnier; Ladan Fazli; Martin Gleave; Ka Mun Nip; Amina Zoubeidi
Hsp27 regulates epithelial mesenchymal transition, metastasis, and circulating tumor cells in prostate cancer.
Maryam Moussavi; John C Bell; Ladan Fazli; William Jia; Howard Tearle; Paul S Rennie
Targeting and killing of metastatic cells in the transgenic adenocarcinoma of mouse prostate model with vesicular stomatitis virus.
Amy A Lubik; Michael Pollak; Nataly Stylianou; Hans H Adomat; Susan Ettinger; Ladan Fazli; Martin E Gleave; Jennifer H Gunter; Stephen C Hendy; Adrian Herington; Brett G Hollier; Colleen C Nelson
IGF2 increases de novo steroidogenesis in prostate cancer cells.

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All Publications

2013: Masaki Shiota; Ario Takeuchi; Anousheh Zardan; Jenny Bazov; Eliana Beraldi; Jennifer L Bishop; Kim Chi; Thomas Cordonnier; Ladan Fazli; Martin Gleave; Ka Mun Nip; Amina Zoubeidi
Hsp27 regulates epithelial mesenchymal transition, metastasis, and circulating tumor cells in prostate cancer.
Cancer research 2013;73(10):3109-19.
2013: Maryam Moussavi; John C Bell; Ladan Fazli; William Jia; Howard Tearle; Paul S Rennie
Targeting and killing of metastatic cells in the transgenic adenocarcinoma of mouse prostate model with vesicular stomatitis virus.
Molecular therapy : the journal of the American Society of Gene Therapy 2013;21(4):842-8.
2013: Amy A Lubik; Michael Pollak; Nataly Stylianou; Hans H Adomat; Susan Ettinger; Ladan Fazli; Martin E Gleave; Jennifer H Gunter; Stephen C Hendy; Adrian Herington; Brett G Hollier; Colleen C Nelson
IGF2 increases de novo steroidogenesis in prostate cancer cells.
Endocrine-related cancer 2013;20(2):173-86.
2013: Wolfgang Jäger; Claudia Janssen; Dirk Lange; Estelle Li; Igor Moskalev; Alan I So; Joachim W Thüroff; Kaixin Zhang; Shannon Awrey; Ladan Fazli; Kilian M Gust; Tetsutaro Hayashi; Peter C Black
Ultrasound-guided intramural inoculation of orthotopic bladder cancer xenografts: a novel high-precision approach.
PloS one 2013;8(3):e59536.
2013: Christopher G Low; Iris S U Luk; Yong Xu; Kuo Yang; Ladan Fazli; Martin Gleave; Peter W Gout; Dong Lin; Yuzhuo Wang
BIRC6 protein, an inhibitor of apoptosis: role in survival of human prostate cancer cells.
PloS one 2013;8(2):e55837.
2013: Sarah Hawley; Javier Hernandez; Antonio Hurtado-coll; Kyle Kuchinsky; Raymond Lance; Janet Liew; Daniel W Lin; Jesse K McKenney; Rosario Mendez-Meza; Peter S Nelson; Lisa F Newcomb; Marlo Nicolas; Jeff Simko; Elizabeth Smith; Imelda Tenggara; Ian M Thompson; Dean Troyer; Lawrence D True; Xiaotun Zhang; Peter R Carroll; June M Chan; Janet E Cowan; Luis Crouch; Ladan Fazli; Ziding Feng; Michelle Ferrari; Martin Gleave; James D Brooks
A model for the design and construction of a resource for the validation of prognostic prostate cancer biomarkers: the Canary Prostate Cancer Tissue Microarray.
Advances in anatomic pathology 2013;20(1):39-44.
2012: Khalil A Choucair; Isabela W Cunha; Joshua Ejdelman; Ladan Fazli; Martin Gleave; Karl-Philippe Guérard; Eleonora Scarlata; Kanishka Sircar; Jeremy A Squire; Maisa Yoshimoto; Armen Aprikian; Fadi Brimo; Simone Chevalier; Jacques Lapointe
The 16p13.3 (PDPK1) Genomic Gain in Prostate Cancer: A Potential Role in Disease Progression.
Translational oncology 2012;5(6):453-60.
2012: Virginie Baylot; Ladan Fazli; Carmen Garrido; Sophie Giusiano; Martin Gleave; Maria Katsogiannou; Julie Acunzo; Claudia Andrieu; David Taieb; Palma Rocchi
Targeting TCTP as a new therapeutic strategy in castration-resistant prostate cancer.
Molecular therapy : the journal of the American Society of Gene Therapy 2012;20(12):2244-56.
2012: Kaijie Wu; Guanghua Xiao; Lin Yang; Eun-Jin Yun; Linlin Zhang; Ladan Fazli; Martin Gleave; Crystal Gore; Dalin He; Payal Kapur; Rey-Chen Pong; Shu-Fen Tseng; Jer-Tsong Hsieh
Slug, a unique androgen-regulated transcription factor, coordinates androgen receptor to facilitate castration resistance in prostate cancer.
Molecular endocrinology (Baltimore, Md.) 2012;26(9):1496-507.
2012: Sophie Giusiano; Martin Gleave; Juan Lucio Iovanna; Claudia Andrieu; Virginie Baylot; Ladan Fazli; Stéphane Garcia; Colette Taranger-Charpin; Palma Rocchi
TP53INP1 as new therapeutic target in castration-resistant prostate cancer.
The Prostate 2012;72(12):1286-94.
2012: Masafumi Kumano; Masaki Shiota; Romina M Wiedmann; Anousheh Zardan; Fan Zhang; Amina Zoubeidi; Eliana Beraldi; Ladan Fazli; Junya Furukawa; Martin E Gleave
Cotargeting stress-activated Hsp27 and autophagy as a combinatorial strategy to amplify endoplasmic reticular stress in prostate cancer.
Molecular cancer therapeutics 2012;11(8):1661-71.
2012: Kim N Chi; Ladan Fazli; Martin E Gleave; S Larry Goldenberg; Christian Kollmannsberger; Nevin Murray; Alan So; Anna Tinker; Michael Pollak
A phase II pharmacodynamic study of preoperative figitumumab in patients with localized prostate cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(12):3407-13.
2012: Latif A Wafa; Helen Cheng; Michael E Cox; Ladan Fazli; Takahiro Fukumoto; Fariba Ghaidi; Martin E Gleave; Nathan Plaa; Paul S Rennie
Carbidopa abrogates L-dopa decarboxylase coactivation of the androgen receptor and delays prostate tumor progression.
International journal of cancer. Journal international du cancer 2012;130(12):2835-44.
2012: Alain Gulenga Musende; Catherine A Wood; Hans Adomat; Marcel B Bally; Andy Eberding; Ladan Fazli; Antonio Hurtado-coll; William Jia; Emma S Tomlinson Guns
A novel oral dosage formulation of the ginsenoside aglycone protopanaxadiol exhibits therapeutic activity against a hormone-insensitive model of prostate cancer.
Anti-cancer drugs 2012;23(5):543-52.
2012: Christian Thomas; Latif A Wafa; Helen Cheng; Ladan Fazli; Martin E Gleave; Francois Lamoureux; Paul S Rennie
Carbidopa enhances antitumoral activity of bicalutamide on the androgen receptor-axis in castration-resistant prostate tumors.
The Prostate 2012;72(8):875-85.
2012: Chunxiao Wu; Alexander W Wyatt; Shawn Anderson; Robert H Bell; Paul C Boutros; Sonal Brahmbhatt; Robert G Bristow; Yaron S N Butterfield; Arul M Chinnaiyan; Ladan Fazli; Martin E Gleave; Faraz Hach; Anne Haegert; IMAN HAJIRASOULIHA; Martin Hirst; Fereydoun Hormozdiari; Antonio Hurtado-coll; Edward C Jones; Steven Jm Jones; Anna V Lapuk; Estelle Li; Christopher A Maher; Marco A Marra; Brian J McConeghy; Andrew McPherson; Fan Mo; S Cenk Sahinalp; Robert Shukin; Stanislav V Volik; Colin C Collins
Integrated genome and transcriptome sequencing identifies a novel form of hybrid and aggressive prostate cancer.
The Journal of pathology 2012;227(1):53-61.
2012: Colin C Collins; Francesca Demichelis; Ladan Fazli; Martin Gleave; Peter W Gout; Anne Haegert; Martin Hirst; Antonio Hurtado-coll; Anna V Lapuk; Martin Lubin; Christopher A Maher; Marco Marra; Mark A Rubin; Stanislav V Volik; Yuwei Wang; Shawn Anderson; Robert H Bell; Himisha Beltran; Joseph R Bertino; Sonal Brahmbhatt; Hongwei Cheng; Arul M Chinnaiyan; Chunxiao Wu; Hui Xue; Yuzhuo Wang
Next generation sequencing of prostate cancer from a patient identifies a deficiency of methylthioadenosine phosphorylase, an exploitable tumor target.
Molecular cancer therapeutics 2012;11(3):775-83.
2012: Sophie Pâquet; Paul S Rennie; Bernard Têtu; Mélanie Verreault; Alain Bélanger; Ladan Fazli; Laurent Grosse; Olivier Barbier
Differential expression of the androgen-conjugating UGT2B15 and UGT2B17 enzymes in prostate tumor cells during cancer progression.
The Journal of clinical endocrinology and metabolism 2012;97(3):E428-32.
2012: Deanna Dryhurst; Ladan Fazli; Bethany McMullen; Paul S Rennie; Juan Ausió
Histone H2A.Z prepares the prostate specific antigen (PSA) gene for androgen receptor-mediated transcription and is upregulated in a model of prostate cancer progression.
Cancer letters 2012;315(1):38-47.
2012: Jing Jiao; Devon Lawson; Yunfeng Li; Linh M Tran; Shunyou Wang; Owen N Witte; Donghui Chen; Ladan Fazli; Isla P Garraway; Martin Gleave; Andrew S Goldstein; Changyong Guo; Antreas Hindoyan; Baohui Zhang; Hong Wu
Identification of CD166 as a surface marker for enriching prostate stem/progenitor and cancer initiating cells.
PloS one 2012;7(8):e42564.
2012: Clement Mugabe; Peter A Raven; Alan I So; Jennifer H E Baker; Donald E Brooks; Ladan Fazli; Martin E Gleave; John K Jackson; Richard T Liggins; Andrew I Minchinton; Helen M Burt
Tissue uptake of docetaxel loaded hydrophobically derivatized hyperbranched polyglycerols and their effects on the morphology of the bladder urothelium.
Biomaterials 2012;33(2):692-703.
2011: Francois Lamoureux; Christian Thomas; Min-Jean Yin; Amina Zoubeidi; Eliana Beraldi; Ladan Fazli; Hidetoshi Kuruma; Martin E Gleave
Clusterin inhibition using OGX-011 synergistically enhances Hsp90 inhibitor activity by suppressing the heat shock response in castrate-resistant prostate cancer.
Cancer research 2011;71(17):5838-49.
2011: Jesse K McKenney; Lisa F Newcomb; Marlo M Nicolas; Jeff Simko; Dean A Troyer; Lawrence True; Funda Vakar-Lopez; Xiaotun Zhang; Michael Bonham; James D Brooks; Peter R Carroll; Ladan Fazli; Sarah Hawley; Lakshmi P Kunju
The potential impact of reproducibility of Gleason grading in men with early stage prostate cancer managed by active surveillance: a multi-institutional study.
The Journal of urology 2011;186(2):465-9.
2011: Charles E Massie; Nik Mathews; Boris Adryan; Helene Bon; Joan Boren; Kevin M Brindle; Gina M Denicola; Ladan Fazli; Martin E Gleave; John Griffiths; james hadfield; Andy Lynch; Scott K Lyons; Stewart Macarthur; Basetti Madhu; David E Neal; Michelle Osborne; Antonio Ramos-Montoya; Paul S Rennie; Helen Scott; Naomi Sharma; Donna-Michelle Smith; Rory Stark; Anne Warren; Vinny Zecchini; Ian G Mills
The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis.
The EMBO journal 2011;30(13):2719-33.
2011: Francois Lamoureux; Christian Thomas; Min-Jean Yin; Hidetoshi Kuruma; Ladan Fazli; Martin E Gleave; Amina Zoubeidi
A novel HSP90 inhibitor delays castrate-resistant prostate cancer without altering serum PSA levels and inhibits osteoclastogenesis.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(8):2301-13.
2011: Christian Thomas; Amina Zoubeidi; Hidetoshi Kuruma; Ladan Fazli; Francois Lamoureux; Eliana Beraldi; Brett P Monia; A Robert MacLeod; Joachim W Thüroff; Martin E Gleave
Transcription factor Stat5 knockdown enhances androgen receptor degradation and delays castration-resistant prostate cancer progression in vivo.
Molecular cancer therapeutics 2011;10(2):347-59.
2010: Hiroshi Tanaka; Evelyn Kono; Chau P Tran; Hideyo Miyazaki; Joyce Yamashiro; Tatsuya Shimomura; Ladan Fazli; Robert Wada; Jiaoti Huang; Robert L Vessella; Jaibin An; Steven Horvath; Martin Gleave; Matthew B Rettig; Zev A Wainberg; Robert E Reiter
Monoclonal antibody targeting of N-cadherin inhibits prostate cancer growth, metastasis and castration resistance.
Nature medicine 2010;16(12):1414-20.
2010: Kai-Xin Zhang; Yoshiyuki Matsui; Boris A Hadaschik; Cleo Lee; William Jia; John C Bell; Ladan Fazli; Alan I So; Paul S Rennie
Down-regulation of type I interferon receptor sensitizes bladder cancer cells to vesicular stomatitis virus-induced cell death.
International journal of cancer. Journal international du cancer 2010;127(4):830-8.
2010: Vanessa C Thompson; Antonio Hurtado-coll; Dmitry Turbin; Ladan Fazli; Melanie L Lehman; Martin E Gleave; Colleen C Nelson
Relaxin drives Wnt signaling through upregulation of PCDHY in prostate cancer.
The Prostate 2010;70(10):1134-45.
2010: Marie-Claude Battista; Marie-Odile Guimond; Claude Roberge; Alexandre A Doueik; Ladan Fazli; Martin Gleave; Robert Sabbagh; Nicole Gallo-Payet
Inhibition of DHCR24/seladin-1 impairs cellular homeostasis in prostate cancer.
The Prostate 2010;70(9):921-33.
2010: Peyman Tavassoli; Latif A Wafa; Helen Cheng; Amina Zoubeidi; Ladan Fazli; Martin Gleave; Robert Snoek; Paul S Rennie
TAF1 differentially enhances androgen receptor transcriptional activity via its N-terminal kinase and ubiquitin-activating and -conjugating domains.
Molecular endocrinology (Baltimore, Md.) 2010;24(4):696-708.
2010: Mark Garzotto; Celestia S Higano; Catherine O'Brien; Brooks L S Rademacher; Nicole Janeba; Ladan Fazli; Paul H Lange; Stephen Lieberman; Tomasz M Beer
Phase 1/2 study of preoperative docetaxel and mitoxantrone for high-risk prostate cancer.
Cancer 2010;116(7):1699-708.
2010: Amina Zoubeidi; Anousheh Zardan; Romina M Wiedmann; Jennifer Locke; Eliana Beraldi; Ladan Fazli; Martin E Gleave
Hsp27 promotes insulin-like growth factor-I survival signaling in prostate cancer via p90Rsk-dependent phosphorylation and inactivation of BAD.
Cancer research 2010;70(6):2307-17.
2010: Maryam Moussavi; Ladan Fazli; Howard Tearle; Yubin Guo; Michael Cox; John Bell; Christopher Ong; William Jia; Paul S Rennie
Oncolysis of prostate cancers induced by vesicular stomatitis virus in PTEN knockout mice.
Cancer research 2010;70(4):1367-76.
2010: Jennifer A Locke; Emma S Guns; Melanie L Lehman; Susan Ettinger; Amina Zoubeidi; Amy Lubik; Katia Margiotti; Ladan Fazli; Hans Adomat; Kishor M Wasan; Martin E Gleave; Colleen C Nelson
Arachidonic acid activation of intratumoral steroid synthesis during prostate cancer progression to castration resistance.
The Prostate 2010;70(3):239-51.
2009: K-x Zhang; M Moussavi; C Kim; E Chow; I S Chen; Ladan Fazli; W Jia; Paul S Rennie
Lentiviruses with trastuzumab bound to their envelopes can target and kill prostate cancer cells.
Cancer gene therapy 2009;16(11):820-31.
2009: Alain G Musende; Andy Eberding; Catherine Wood; Hans Adomat; Ladan Fazli; Antonio Hurtado-coll; William Jia; Marcel B Bally; Emma Tomlinson Guns
Pre-clinical evaluation of Rh2 in PC-3 human xenograft model for prostate cancer in vivo: formulation, pharmacokinetics, biodistribution and efficacy.
Cancer chemotherapy and pharmacology 2009;64(6):1085-95.
2009: Yoshiyuki Matsui; Boris A Hadaschik; Ladan Fazli; Raymond J Andersen; Martin E Gleave; Alan I So
Intravesical combination treatment with antisense oligonucleotides targeting heat shock protein-27 and HTI-286 as a novel strategy for high-grade bladder cancer.
Molecular cancer therapeutics 2009;8(8):2402-11.
2009: Jennifer A Locke; Ladan Fazli; Hans Adomat; Jil Smyl; Kristin Weins; Amy A Lubik; Dale Buchanan Hales; Colleen C Nelson; Martin E Gleave; Emma S Tomlinson Guns
A novel communication role for CYP17A1 in the progression of castration-resistant prostate cancer.
The Prostate 2009;69(9):928-37.
2009: Robert Snoek; Helen Cheng; Katia Margiotti; Latif A Wafa; Charmaine A Wong; Erica Chan Wong; Ladan Fazli; Colleen C Nelson; Martin E Gleave; Paul S Rennie
In vivo knockdown of the androgen receptor results in growth inhibition and regression of well-established, castration-resistant prostate tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(1):39-47.
2009: Michael E Cox; Martin E Gleave; Mahvash Zakikhani; Robert H Bell; Esther Piura; Elaine Vickers; Matthew Cunningham; Ola Larsson; Ladan Fazli; Michael Pollak
Insulin receptor expression by human prostate cancers.
The Prostate 2009;69(1):33-40.
2008: Alan I So; Randy Levitt; Bernhard Eigl; Ladan Fazli; Motosugu Muramaki; Sam Leung; Maggie C U Cheang; Torsten O Nielsen; Martin Gleave; Michael Pollak
Insulin-like growth factor binding protein-2 is a novel therapeutic target associated with breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(21):6944-54.
2008: Shintaro Narita; Alan So; Susan Ettinger; Norihiro Hayashi; Mototsugu Muramaki; Ladan Fazli; Youngsoo Kim; Martin E Gleave
GLI2 knockdown using an antisense oligonucleotide induces apoptosis and chemosensitizes cells to paclitaxel in androgen-independent prostate cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(18):5769-77.
2008: Boris A Hadaschik; Ryan F Paterson; Ladan Fazli; Kenneth W Clinkscales; Shalaby W Shalaby; Ben H Chew
Investigation of a novel degradable ureteral stent in a porcine model.
The Journal of urology 2008;180(3):1161-6.
2008: Norihiro Hayashi; Erich Koller; Ladan Fazli; Martin E Gleave
Effects of Eg5 knockdown on human prostate cancer xenograft growth and chemosensitivity.
The Prostate 2008;68(12):1283-95.
2008: Boris A Hadaschik; John Jackson; Ladan Fazli; Amina Zoubeidi; Helen M Burt; Martin E Gleave; Alan I So
Intravesically administered antisense oligonucleotides targeting heat-shock protein-27 inhibit the growth of non-muscle-invasive bladder cancer.
BJU international 2008;102(5):610-6.
2008: Richard D Sowery; Boris A Hadaschik; Alan I So; Amina Zoubeidi; Ladan Fazli; Antonio Hurtado-coll; Martin E Gleave
Clusterin knockdown using the antisense oligonucleotide OGX-011 re-sensitizes docetaxel-refractory prostate cancer PC-3 cells to chemotherapy.
BJU international 2008;102(3):389-97.
2008: Boris A Hadaschik; Kaixin Zhang; Alan I So; Ladan Fazli; William Jia; John C Bell; Martin E Gleave; Paul S Rennie
Oncolytic vesicular stomatitis viruses are potent agents for intravesical treatment of high-risk bladder cancer.
Cancer research 2008;68(12):4506-10.
2008: Dong Lin; Akira Watahiki; Jane Bayani; Fang Zhang; Lin Liu; Victor Ling; Marianne D Sadar; John English; Ladan Fazli; Alan So; Peter W Gout; Martin Gleave; Jeremy A Squire; Yu-Zhuo Wang
ASAP1, a gene at 8q24, is associated with prostate cancer metastasis.
Cancer research 2008;68(11):4352-9.
2008: Boris A Hadaschik; Hans Adomat; Ladan Fazli; Yves Fradet; Raymond J Andersen; Martin E Gleave; Alan I So
Intravesical chemotherapy of high-grade bladder cancer with HTI-286, a synthetic analogue of the marine sponge product hemiasterlin.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(5):1510-8.
2008: Yingqiu Xie; Kexin Xu; Douglas E Linn; Xi Yang; Zhiyong Guo; Hermela Shimelis; Takeo Nakanishi; Douglas Ross; Hegang Chen; Ladan Fazli; Martin E Gleave; Yun Qiu
The 44-kDa Pim-1 kinase phosphorylates BCRP/ABCG2 and thereby promotes its multimerization and drug-resistant activity in human prostate cancer cells.
The Journal of biological chemistry 2008;283(6):3349-56.
2008: Liesel M FitzGerald; Ilir Agalliu; Karynn Johnson; Melinda A Miller; Erika M Kwon; Antonio Hurtado-coll; Ladan Fazli; Ashish B Rajput; Martin E Gleave; Michael E Cox; Elaine A Ostrander; Janet L Stanford; David Huntsman
Association of TMPRSS2-ERG gene fusion with clinical characteristics and outcomes: results from a population-based study of prostate cancer.
BMC cancer 2008;8():230.
2007: Boris A Hadaschik; Peter C Black; Jason C Sea; Adam R Metwalli; Ladan Fazli; Colin P N Dinney; Martin E Gleave; Alan I So
A validated mouse model for orthotopic bladder cancer using transurethral tumour inoculation and bioluminescence imaging.
BJU international 2007;100(6):1377-84.
2007: Amina Zoubeidi; Anousheh Zardan; Eliana Beraldi; Ladan Fazli; Richard Sowery; Paul S Rennie; Colleen Nelson; Martin Gleave
Cooperative interactions between androgen receptor (AR) and heat-shock protein 27 facilitate AR transcriptional activity.
Cancer research 2007;67(21):10455-65.
2007: Chang Xu; Lynn F Graf; Ladan Fazli; Ilsa Coleman; Denise E Mauldin; Danbin Li; Peter S Nelson; Martin Gleave; Stephen R Plymate; Michael E Cox; Beverly J Torok-Storb; Beatrice S Knudsen
Regulation of global gene expression in the bone marrow microenvironment by androgen: androgen ablation increases insulin-like growth factor binding protein-5 expression.
The Prostate 2007;67(15):1621-9.
2007: Jonathan C Low; Kishor M Wasan; Ladan Fazli; Andy Eberding; Hans Adomat; Emma S Guns
Assessing the therapeutic and toxicological effects of cesium chloride following administration to nude mice bearing PC-3 or LNCaP prostate cancer xenografts.
Cancer chemotherapy and pharmacology 2007;60(6):821-9.
2007: Ashish B Rajput; Melinda A Miller; Alessandro De Luca; Niki Boyd; Sam Leung; Antonio Hurtado-coll; Ladan Fazli; Edward C Jones; Jodie B Palmer; Martin E Gleave; Michael E Cox; David Huntsman
Frequency of the TMPRSS2:ERG gene fusion is increased in moderate to poorly differentiated prostate cancers.
Journal of clinical pathology 2007;60(11):1238-43.
2007: Meritxell Gironella; Mylène Seux; Min-Jue Xie; Carla Cano; Richard Tomasini; Julien Gommeaux; Stephane Garcia; Jonathan Nowak; Man Lung Yeung; Kuan-Teh Jeang; Amandine Chaix; Ladan Fazli; Yoshiharu Motoo; Qing Wang; Palma Rocchi; Antonio Russo; Martin Gleave; Jean-Charles Dagorn; Juan L Iovanna; Alice Carrier; Marie-Josèphe Pébusque; Nelson J Dusetti
Tumor protein 53-induced nuclear protein 1 expression is repressed by miR-155, and its restoration inhibits pancreatic tumor development.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(41):16170-5.
2007: Ritwik Ghosh; Guangyu Gu; Erin Tillman; Jialing Yuan; Yongqing Wang; Ladan Fazli; Paul S Rennie; Susan Kasper
Increased expression and differential phosphorylation of stathmin may promote prostate cancer progression.
The Prostate 2007;67(10):1038-52.
2007: Elahe A Mostaghel; Stephanie T Page; Daniel W Lin; Ladan Fazli; Ilsa Coleman; Lawrence True; Beatrice Knudsen; David L Hess; Colleen C Nelson; Alvin M Matsumoto; William J Bremner; Martin E Gleave; Peter S Nelson
Intraprostatic androgens and androgen-regulated gene expression persist after testosterone suppression: therapeutic implications for castration-resistant prostate cancer.
Cancer research 2007;67(10):5033-41.
2007: J Erin Tillman; Jialing Yuan; Guangyu Gu; Ladan Fazli; Ritwik Ghosh; Alex S Flynt; Martin Gleave; Paul S Rennie; Susan Kasper
DJ-1 binds androgen receptor directly and mediates its activity in hormonally treated prostate cancer cells.
Cancer research 2007;67(10):4630-7.
2007: Donald T T Yapp; Janet Woo; Aileen Kartono; Jonathan Sy; Thomas Oliver; Kirsten Skov; Cameron J Koch; Hans Adomat; Wieslawa H Dragowska; Ladan Fazli; Ladan Fadzli; Thomas J Ruth; Michael J Adam; David Green; Martin Gleave
Non-invasive evaluation of tumour hypoxia in the Shionogi tumour model for prostate cancer with 18F-EF5 and positron emission tomography.
BJU international 2007;99(5):1154-60.
2007: Latif A Wafa; Jodie Palmer; Ladan Fazli; Antonio Hurtado-coll; Robert H Bell; Colleen C Nelson; Martin E Gleave; Michael E Cox; Paul S Rennie
Comprehensive expression analysis of L-dopa decarboxylase and established neuroendocrine markers in neoadjuvant hormone-treated versus varying Gleason grade prostate tumors.
Human pathology 2007;38(1):161-70.
2006: Vanessa C Thompson; Tanis G W Morris; Dawn R Cochrane; John Cavanagh; Latif A Wafa; Tatyana Hamilton; Shunyou Wang; Ladan Fazli; Martin E Gleave; Colleen C Nelson
Relaxin becomes upregulated during prostate cancer progression to androgen independence and is negatively regulated by androgens.
The Prostate 2006;66(16):1698-709.
2006: Palma Rocchi; Paul Jugpal; Alan So; Shannon Sinneman; Susan Ettinger; Ladan Fazli; Colleen Nelson; Martin Gleave
Small interference RNA targeting heat-shock protein 27 inhibits the growth of prostatic cell lines and induces apoptosis via caspase-3 activation in vitro.
BJU international 2006;98(5):1082-9.
2006: Dieter Fink; Ladan Fazli; Bruce Aronow; Martin E Gleave; Christopher J Ong
Clusterin is not essential for androgen-regulated involution and regeneration of the normal mouse prostate.
The Prostate 2006;66(13):1445-54.
2006: Satoko Kojima; David J Mulholland; Susan Ettinger; Ladan Fazli; Colleen C Nelson; Martin E Gleave
Differential regulation of IGFBP-3 by the androgen receptor in the lineage-related androgen-dependent LNCaP and androgen-independent C4-2 prostate cancer models.
The Prostate 2006;66(9):971-86.
2006: Jerod Bertram; James W Peacock; Ladan Fazli; Alice L-F Mui; Stephen W Chung; Michael E Cox; Brett P Monia; Martin E Gleave; Christopher J Ong
Loss of PTEN is associated with progression to androgen independence.
The Prostate 2006;66(9):895-902.
2006: Kazuki Yamanaka; Palma Rocchi; Hideaki Miyake; Ladan Fazli; Alan So; Uwe Zangemeister-Wittke; Martin E Gleave
Induction of apoptosis and enhancement of chemosensitivity in human prostate cancer LNCaP cells using bispecific antisense oligonucleotide targeting Bcl-2 and Bcl-xL genes.
BJU international 2006;97(6):1300-8.
2006: Xiaowei Xie; Andy Eberding; Candice Madera; Ladan Fazli; William Jia; Larry Goldenberg; Martin Gleave; Emma S Guns
Rh2 synergistically enhances paclitaxel or mitoxantrone in prostate cancer models.
The Journal of urology 2006;175(5):1926-31.
2006: Mira R Ray; Latif A Wafa; Helen Cheng; Rob Snoek; Ladan Fazli; Martin Gleave; Paul S Rennie
Cyclin G-associated kinase: a novel androgen receptor-interacting transcriptional coactivator that is overexpressed in hormone refractory prostate cancer.
International journal of cancer. Journal international du cancer 2006;118(5):1108-19.
2006: Duan Yu; C Scott; William W-G Jia; Arrigo De Benedetti; B Jill Williams; Ladan Fazli; Y Wen; Martin Gleave; C Nelson; Paul S Rennie
Targeting and killing of prostate cancer cells using lentiviral constructs containing a sequence recognized by translation factor eIF4E and a prostate-specific promoter.
Cancer gene therapy 2006;13(1):32-43.
2005: Alan So; Shannon Sinnemann; David Huntsman; Ladan Fazli; Martin Gleave
Knockdown of the cytoprotective chaperone, clusterin, chemosensitizes human breast cancer cells both in vitro and in vivo.
Molecular cancer therapeutics 2005;4(12):1837-49.
2005: Palma Rocchi; Eliana Beraldi; Susan Ettinger; Ladan Fazli; Robert L Vessella; Colleen Nelson; Martin Gleave
Increased Hsp27 after androgen ablation facilitates androgen-independent progression in prostate cancer via signal transducers and activators of transcription 3-mediated suppression of apoptosis.
Cancer research 2005;65(23):11083-93.
2005: Kazuki Yamanaka; Palma Rocchi; Hideaki Miyake; Ladan Fazli; Bob Vessella; Uwe Zangemeister-Wittke; Martin E Gleave
A novel antisense oligonucleotide inhibiting several antiapoptotic Bcl-2 family members induces apoptosis and enhances chemosensitivity in androgen-independent human prostate cancer PC3 cells.
Molecular cancer therapeutics 2005;4(11):1689-98.
2005: Kim N Chi; Elizabeth Eisenhauer; Ladan Fazli; Edward C Jones; S Larry Goldenberg; Jean Powers; Dongsheng Tu; Martin E Gleave
A phase I pharmacokinetic and pharmacodynamic study of OGX-011, a 2'-methoxyethyl antisense oligonucleotide to clusterin, in patients with localized prostate cancer.
Journal of the National Cancer Institute 2005;97(17):1287-96.
2005: Beatrice S Knudsen; Jared M Lucas; Ladan Fazli; Sarah Hawley; Seth Falcon; Ilsa Coleman; Daniel B Martin; Chang Xu; Lawrence True; Martin E Gleave; Peter S Nelson; Gustavo E Ayala
Regulation of hepatocyte activator inhibitor-1 expression by androgen and oncogenic transformation in the prostate.
The American journal of pathology 2005;167(1):255-66.
2004: Sandra L Krueckl; Robert A Sikes; N Magnus Edlund; Robert H Bell; Antonio Hurtado-coll; Ladan Fazli; Martin E Gleave; Michael E Cox
Increased insulin-like growth factor I receptor expression and signaling are components of androgen-independent progression in a lineage-derived prostate cancer progression model.
Cancer research 2004;64(23):8620-9.
2004: Palma Rocchi; Alan So; Satoko Kojima; Maxim Signaevsky; Eliana Beraldi; Ladan Fazli; Antonio Hurtado-coll; Kazuki Yamanaka; Martin Gleave
Heat shock protein 27 increases after androgen ablation and plays a cytoprotective role in hormone-refractory prostate cancer.
Cancer research 2004;64(18):6595-602.
2004: Laura V July; Eliana Beraldi; Alan So; Ladan Fazli; Kenneth Evans; John C English; Martin E Gleave
Nucleotide-based therapies targeting clusterin chemosensitize human lung adenocarcinoma cells both in vitro and in vivo.
Molecular cancer therapeutics 2004;3(3):223-32.
2004: Clara Tan; Séverine Cruet-Hennequart; Armelle A Troussard; Ladan Fazli; Penny Costello; Kym Sutton; Jeff Wheeler; Martin Gleave; Jasbinder S Sanghera; Shoukat Dedhar
Regulation of tumor angiogenesis by integrin-linked kinase (ILK).
Cancer cell 2004;5(1):79-90.
2002: N Yoganathan; A Yee; Z Zhang; D Leung; J Yan; Ladan Fazli; D L Kojic; Penny Costello; Mogjan Jabali; Shoukat Dedhar; Jasbinder S Sanghera
Integrin-linked kinase, a promising cancer therapeutic target: biochemical and biological properties.
Pharmacology & therapeutics 2002;93(2-3):233-42.

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