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Eric Fearon

Research Profile

Chemicals & Drugs

Genes & Molecular Sequences

Physiology

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Mouse

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Rong Wu; Suzanne J Baker; Eric R Fearon; Tom C Hu; Kyle M Norman; Kathleen R Cho
Type I to type II ovarian carcinoma progression: mutant Trp53 or Pik3ca confers a more aggressive tumor phenotype in a mouse model of ovarian cancer.
Sergei I Grivennikov; Kenneth E Hung; Dominik Jauch; Hilde Cheroutre; Vincenzo Coppola; Christian Datz; Lars Eckmann; Eric R Fearon; Ying Feng; Daniel Mucida; Christoph H Osterreicher; Mohamed Oukka; Bernd Schnabl; C Andrew Stewart; Koji Taniguchi; Lino Tessarollo; Giorgio Trinchieri; Kepeng Wang; Felix Yarovinsky; Guann-Yi Yu; Michael Karin
Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth.
Stephanie Blij; Eric R Fearon; Tristan Frum; Aytekin Akyol; Amy Ralston
Maternal Cdx2 is dispensable for mouse development.

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All Publications

2013: Rong Wu; Suzanne J Baker; Eric R Fearon; Tom C Hu; Kyle M Norman; Kathleen R Cho
Type I to type II ovarian carcinoma progression: mutant Trp53 or Pik3ca confers a more aggressive tumor phenotype in a mouse model of ovarian cancer.
The American journal of pathology 2013;182(4):1391-9.
2012: Sergei I Grivennikov; Kenneth E Hung; Dominik Jauch; Hilde Cheroutre; Vincenzo Coppola; Christian Datz; Lars Eckmann; Eric R Fearon; Ying Feng; Daniel Mucida; Christoph H Osterreicher; Mohamed Oukka; Bernd Schnabl; C Andrew Stewart; Koji Taniguchi; Lino Tessarollo; Giorgio Trinchieri; Kepeng Wang; Felix Yarovinsky; Guann-Yi Yu; Michael Karin
Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth.
Nature 2012;491(7423):254-8.
2012: Stephanie Blij; Eric R Fearon; Tristan Frum; Aytekin Akyol; Amy Ralston
Maternal Cdx2 is dispensable for mouse development.
Development (Cambridge, England) 2012;139(21):3969-72.
2012: Eric R Fearon; Jason R Spence
Cancer biology: a new RING to Wnt signaling.
Current biology : CB 2012;22(19):R849-51.
2012: Sharon J Miller; Alnawaz Rehemtulla; Brian D Ross; Eric R Fearon; Ying Feng; Craig J Galban; Kevin A Heist; Thomas D Wang
Multimodal imaging of growth and rapamycin-induced regression of colonic adenomas in apc mutation-dependent mouse.
Translational oncology 2012;5(5):313-20.
2012: Zhao-Qiu Wu; Amanda L Willis; Thomas Brabletz; Eric R Fearon; Casey Yuexian Hu; Xiao-Yan Li; Stephen J Weiss
Canonical Wnt suppressor, Axin2, promotes colon carcinoma oncogenic activity.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(28):11312-7.
2012: Wei Dou; Eric R Fearon; Ying Feng; Sandhya Kortagere; Hao Li; Subhajit Mukherjee; Ariel Peleg; Madhukumar Venkatesh; Hongwei Wang; Zheng-Tao Wang; Sridhar S Chilimuri; venkatesh madhukumar
Alleviation of gut inflammation by Cdx2/Pxr pathway in a mouse model of chemical colitis.
PloS one 2012;7(7):e36075.
2011: Rong Wu; Eric R Fearon; Tom C Hu; Alnawaz Rehemtulla; Kathleen R Cho
Preclinical testing of PI3K/AKT/mTOR signaling inhibitors in a mouse model of ovarian endometrioid adenocarcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(23):7359-72.
2011: Nam Hee Kim; Inhan Lee; Sanghyuk Lee; Xiao-Yan Li; Christopher A. Maher; R Grant Rowe; Joo Kyung Ryu; Stephen J Weiss; So Young Cha; Hyung-Seok Choi; Eric R Fearon; Shi Eun Kang; Hyun Sil Kim; Dojun Yoon; Jong In Yook
A p53/miRNA-34 axis regulates Snail1-dependent cancer cell epithelial-mesenchymal transition.
The Journal of cell biology 2011;195(3):417-33.
2011: Eric R Fearon
The sweet secrets of p27kip1 regulation and function in cell migration.
Cell cycle (Georgetown, Tex.) 2011;10(20):3429.
2011: Yali Zhai; Eric R Fearon; Ying Feng; A Iura; A B Wiese; Rong Wu; S Yeasmin; Kathleen R Cho
MSX2 is an oncogenic downstream target of activated WNT signaling in ovarian endometrioid adenocarcinoma.
Oncogene 2011;30(40):4152-62.
2011: Ying Feng; Maranne Green; Evan Sands; Yali Zhai; Jenny Zhao; Bommer Guido; Kelly Brown; Aaron Burberry; Kathleen R Cho; Eric R Fearon
Mutant KRAS promotes hyperplasia and alters differentiation in the colon epithelium but does not expand the presumptive stem cell pool.
Gastroenterology 2011;141(3):1003-1013.e1-10.
2011: Sharon J Miller; Bishnu P Joshi; Ying Feng; Adam Gaustad; Eric R Fearon; Thomas D Wang
In vivo fluorescence-based endoscopic detection of colon dysplasia in the mouse using a novel peptide probe.
PloS one 2011;6(3):e17384.
2011: Eric R Fearon
Molecular genetics of colorectal cancer.
Annual review of pathology 2011;6():479-507.
2010: Yuji Takakura; T Hinoi; Naohide Oue; Tatsunari Sasada; Yasuo Kawaguchi; Masazumi Okajima; Aytekin Akyol; Eric R Fearon; Wataru Yasui; Hideki Ohdan
CDX2 regulates multidrug resistance 1 gene expression in malignant intestinal epithelium.
Cancer research 2010;70(17):6767-78.
2010: Yali Zhai; Guido Bommer; Ying Feng; Alexandra B Wiese; Eric R Fearon; Kathleen R Cho
Loss of estrogen receptor 1 enhances cervical cancer invasion.
The American journal of pathology 2010;177(2):884-95.
2010: Bart van De Sluis; Xicheng Mao; Yali Zhai; Arjan J Groot; Jeroen F Vermeulen; ELSKEN VAN DER WALL; Paulus van Diest; Marten H Hofker; Cisca Wijmenga; Leo W Klomp; Kathleen R Cho; Eric R Fearon; Marc Vooijs; Ezra Burstein
COMMD1 disrupts HIF-1alpha/beta dimerization and inhibits human tumor cell invasion.
The Journal of clinical investigation 2010;120(6):2119-30.
2010: Mitsuo Goto; Raj S Mitra; Min Liu; Julia Lee; Bradley S Henson; Thomas Carey; Carol R Bradford; Mark E Prince; Cun-Yu Wang; Eric R Fearon; Nisha J D'Silva
Rap1 stabilizes beta-catenin and enhances beta-catenin-dependent transcription and invasion in squamous cell carcinoma of the head and neck.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(1):65-76.
2009: Eric R Fearon
PARsing the phrase "all in for Axin"- Wnt pathway targets in cancer.
Cancer cell 2009;16(5):366-8.
2009: Mark Shackleton; Elsa Quintana; Eric R Fearon; Sean J Morrison
Heterogeneity in cancer: cancer stem cells versus clonal evolution.
Cell 2009;138(5):822-9.
2009: Eduardo Vilar; Bhramar Mukherjee; Rork Kuick; Leonid Raskin; David E Misek; Jeremy Taylor; Thomas J Giordano; Samir M Hanash; Eric R Fearon; Gad Rennert; Stephen B Gruber
Gene expression patterns in mismatch repair-deficient colorectal cancers highlight the potential therapeutic role of inhibitors of the phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin pathway.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(8):2829-39.
2009: Lidong Wang; David G Heidt; Cheong J Lee; Huibin Yang; Craig D Logsdon; Lizhi Zhang; Eric R Fearon; Mats Ljungman; Diane M Simeone
Oncogenic function of ATDC in pancreatic cancer through Wnt pathway activation and beta-catenin stabilization.
Cancer cell 2009;15(3):207-19.
2009: Robert Rowe; Xiao-Yan Li; Yuexian Hu; Thomas L Saunders; Ismo Virtanen; Antonio Garcia de Herreros; Karl-Friedrich Becker; Signe Ingvarsen; Lars H Engelholm; Guido Bommer; Eric R Fearon; Stephen J Weiss
Mesenchymal cells reactivate Snail1 expression to drive three-dimensional invasion programs.
The Journal of cell biology 2009;184(3):399-408.
2008: Navneet Sangha; Rong Wu; Rork Kuick; Scott Powers; David Mu; Diane Fiander; Kit Yuen; Hidetaka Katabuchi; Hironori Tashiro; Eric R Fearon; Kathleen R Cho
Neurofibromin 1 (NF1) defects are common in human ovarian serous carcinomas and co-occur with TP53 mutations.
Neoplasia (New York, N.Y.) 2008;10(12):1362-72, following 1372.
2008: E L Whiteman; Chia-Jen Liu; Eric R Fearon; Benjamin L Margolis
The transcription factor snail represses Crumbs3 expression and disrupts apico-basal polarity complexes.
Oncogene 2008;27(27):3875-9.
2008: Ezra Burstein; Eric R Fearon
Colitis and cancer: a tale of inflammatory cells and their cytokines.
The Journal of clinical investigation 2008;118(2):464-7.
2007: Yali Zhai; Rork Kuick; Bin Nan; Ichiro Ota; Stephen J Weiss; Cornelia L Trimble; Eric R Fearon; Kathleen R Cho
Gene expression analysis of preinvasive and invasive cervical squamous cell carcinomas identifies HOXC10 as a key mediator of invasion.
Cancer research 2007;67(21):10163-72.
2007: Takao Hinoi; Aytekin Akyol; Brian K Theisen; David O Ferguson; Joel K Greenson; Bart Williams; Kathleen R Cho; Eric R Fearon
Mouse model of colonic adenoma-carcinoma progression based on somatic Apc inactivation.
Cancer research 2007;67(20):9721-30.
2007: Rong Wu; Neali Hendrix-Lucas; Rork Kuick; Yali Zhai; Donald R Schwartz; Aytekin Akyol; Samir Hanash; David E Misek; Hidetaka Katabuchi; Bart Williams; Eric R Fearon; Kathleen R Cho
Mouse model of human ovarian endometrioid adenocarcinoma based on somatic defects in the Wnt/beta-catenin and PI3K/Pten signaling pathways.
Cancer cell 2007;11(4):321-33.
2006: Jong In Yook; Xiao-Yan Li; Ichiro Ota; Casey Hu; Hyun Sil Kim; Nam Hee Kim; So Young Cha; Joo Kyung Ryu; Yoon Jung Choi; Jin Kim; Eric R Fearon; Stephen J Weiss
A Wnt-Axin2-GSK3beta cascade regulates Snail1 activity in breast cancer cells.
Nature cell biology 2006;8(12):1398-406.
2006: Neali D Hendrix; Rong Wu; Rork Kuick; Donald R Schwartz; Eric R Fearon; Kathleen R Cho
Fibroblast growth factor 9 has oncogenic activity and is a downstream target of Wnt signaling in ovarian endometrioid adenocarcinomas.
Cancer research 2006;66(3):1354-62.
2005: Laura S Rozek; Steven M Lipkin; Eric R Fearon; Samir Hanash; Thomas J Giordano; Joel K Greenson; Rork Kuick; David E Misek; Jeremy Taylor; Julie A Douglas; Gad Rennert; Stephen B Gruber
CDX2 polymorphisms, RNA expression, and risk of colorectal cancer.
Cancer research 2005;65(13):5488-92.
2005: Eric R Fearon; Ken M Cadigan
Cell biology. Wnt signaling glows with RNAi.
Science (New York, N.Y.) 2005;308(5723):801-3.
2005: Takao Hinoi; Galina Gesina; Aytekin Akyol; Rork Kuick; Samir Hanash; Thomas J Giordano; Stephen B Gruber; Eric R Fearon
CDX2-regulated expression of iron transport protein hephaestin in intestinal and colonic epithelium.
Gastroenterology 2005;128(4):946-61.
2005: Jong In Yook; Xiao-Yan Li; Ichiro Ota; Eric R Fearon; Stephen J Weiss
Wnt-dependent regulation of the E-cadherin repressor snail.
The Journal of biological chemistry 2005;280(12):11740-8.
2005: Kerby Shedden; Malti P Kshirsagar; Donald R Schwartz; Rong Wu; Hongfeng Yu; David E Misek; Samir Hanash; Hidetaka Katabuchi; Lora Hedrick Ellenson; Eric R Fearon; Kathleen R Cho
Histologic type, organ of origin, and Wnt pathway status: effect on gene expression in ovarian and uterine carcinomas.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(6):2123-31.
2005: Kerby Shedden; Wei Chen; Rork Kuick; Debashis Ghosh; James Macdonald; Kathleen R Cho; Thomas J Giordano; Stephen B Gruber; Eric R Fearon; Jeremy Taylor; Samir Hanash
Comparison of seven methods for producing Affymetrix expression scores based on False Discovery Rates in disease profiling data.
BMC bioinformatics 2005;6():26.
2004: Chi-Ming Li; Connie E Kim; Adam A Margolin; Meirong Guo; Jimmy Zhu; Jacqueline M Mason; Terrence W Hensle; Vundavalli Murty; Paul E Grundy; Eric R Fearon; Vivette D'Agati; Jonathan D Licht; Benjamin Tycko
CTNNB1 mutations and overexpression of Wnt/beta-catenin target genes in WT1-mutant Wilms' tumors.
The American journal of pathology 2004;165(6):1943-53.
2004: Weiquan Li; Jeeyong Lee; Haris G Vikis; Seung-Hee Lee; Guofa Liu; Jennifer Aurandt; Tang-Long Shen; Eric R Fearon; Jun-Lin Guan; Min Han; Yi Rao; Kyonsoo Hong; Kun-Liang Guan
Activation of FAK and Src are receptor-proximal events required for netrin signaling.
Nature neuroscience 2004;7(11):1213-21.
2004: Eric R Fearon; Kathleen R Cho
Cancer: cell survival guide.
Nature 2004;431(7004):35-6.
2004: Patrick Mehlen; Eric R Fearon
Role of the dependence receptor DCC in colorectal cancer pathogenesis.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2004;22(16):3420-8.
2004: Steven M Lipkin; Laura S Rozek; Gad Rennert; Wei Yang; Peng-Chieh Chen; Joseph G Hacia; Nathan Hunt; Brian Shin; Steve Fodor; Mark Kokoris; Joel K Greenson; Eric R Fearon; Henry Lynch; Francis S Collins; Stephen B Gruber
The MLH1 D132H variant is associated with susceptibility to sporadic colorectal cancer.
Nature genetics 2004;36(7):694-9.
2004: Eric R Fearon
Defining the microsatellite instability phenotype in colorectal cancer through analysis of surrogate markers.
Cancer biology & therapy 2004;3(1):79-81.
2003: Ying Feng; Nana Lee; Eric R Fearon
TIP49 regulates beta-catenin-mediated neoplastic transformation and T-cell factor target gene induction via effects on chromatin remodeling.
Cancer research 2003;63(24):8726-34.
2003: Takao Hinoi; Massimo Loda; Eric R Fearon
Silencing of CDX2 expression in colon cancer via a dominant repression pathway.
The Journal of biological chemistry 2003;278(45):44608-16.
2003: Kerby Shedden; Jeremy Taylor; Thomas J Giordano; Rork Kuick; David E Misek; Gad Rennert; Donald R Schwartz; Stephen B Gruber; Craig D Logsdon; Diane M Simeone; Sharon L R Kardia; Joel K Greenson; Kathleen R Cho; David G Beer; Eric R Fearon; Samir Hanash
Accurate molecular classification of human cancers based on gene expression using a simple classifier with a pathological tree-based framework.
The American journal of pathology 2003;163(5):1985-95.
2003: Paul J Kim; Janet Plescia; Hans Clevers; Eric R Fearon; Dario C Altieri
Survivin and molecular pathogenesis of colorectal cancer.
Lancet 2003;362(9379):205-9.
2003: Donald R Schwartz; Rong Wu; Sharon L R Kardia; Al Levin; Chiang-Ching Huang; Kerby Shedden; Rork Kuick; David E Misek; Samir M Hanash; Jeremy Taylor; Heather Reed; Neali Hendrix; Yali Zhai; Eric R Fearon; Kathleen R Cho
Novel candidate targets of beta-catenin/T-cell factor signaling identified by gene expression profiling of ovarian endometrioid adenocarcinomas.
Cancer research 2003;63(11):2913-22.
2003: David Van Mater; Frank T Kolligs; Andrzej Dlugosz; Eric R Fearon
Transient activation of beta -catenin signaling in cutaneous keratinocytes is sufficient to trigger the active growth phase of the hair cycle in mice.
Genes & development 2003;17(10):1219-24.
2003: Rong Wu; Lin Lin; David G Beer; Lora Hedrick Ellenson; Barbara J Lamb; Jean-Marie Rouillard; Rork Kuick; Samir Hanash; Donald R Schwartz; Eric R Fearon; Kathleen R Cho
Amplification and overexpression of the L-MYC proto-oncogene in ovarian carcinomas.
The American journal of pathology 2003;162(5):1603-10.
2003: Eric R Fearon
Connecting estrogen receptor function, transcriptional repression, and E-cadherin expression in breast cancer.
Cancer cell 2003;3(4):307-10.
2002: Takao Hinoi; Peter C Lucas; Rork Kuick; Samir Hanash; Kathleen R Cho; Eric R Fearon
CDX2 regulates liver intestine-cadherin expression in normal and malignant colon epithelium and intestinal metaplasia.
Gastroenterology 2002;123(5):1565-77.
2002: Donald R Schwartz; Sharon L R Kardia; Kerby Shedden; Rork Kuick; George Michailidis; Jeremy Taylor; David E Misek; Rong Wu; Yali Zhai; Danielle M Darrah; Heather Reed; Lora Hedrick Ellenson; Thomas J Giordano; Eric R Fearon; Samir M Hanash; Kathleen R Cho
Gene expression in ovarian cancer reflects both morphology and biological behavior, distinguishing clear cell from other poor-prognosis ovarian carcinomas.
Cancer research 2002;62(16):4722-9.
2002: David Qualtrough; T Hinoi; Eric R Fearon; Christos Paraskeva
Expression of CDX2 in normal and neoplastic human colon tissue and during differentiation of an in vitro model system.
Gut 2002;51(2):184-90.
2002: Karen M Hajra; Eric R Fearon
Cadherin and catenin alterations in human cancer.
Genes, chromosomes & cancer 2002;34(3):255-68.
2002: Janet Y Leung; Frank T Kolligs; Rong Wu; Yali Zhai; Rork Kuick; Samir Hanash; Kathleen R Cho; Eric R Fearon
Activation of AXIN2 expression by beta-catenin-T cell factor. A feedback repressor pathway regulating Wnt signaling.
The Journal of biological chemistry 2002;277(24):21657-65.
2002: Yali Zhai; Rong Wu; Donald R Schwartz; Danielle Darrah; Heather Reed; Frank T Kolligs; Marvin T Nieman; Eric R Fearon; Kathleen R Cho
Role of beta-catenin/T-cell factor-regulated genes in ovarian endometrioid adenocarcinomas.
The American journal of pathology 2002;160(4):1229-38.
2002: Karen M Hajra; David Y-S Chen; Eric R Fearon
The SLUG zinc-finger protein represses E-cadherin in breast cancer.
Cancer research 2002;62(6):1613-8.
2002: Frank T Kolligs; Marvin T Nieman; Ira Winer; Gang Hu; David Van Mater; Ying Feng; Ian M Smith; Rong Wu; Yali Zhai; Kathleen R Cho; Eric R Fearon
ITF-2, a downstream target of the Wnt/TCF pathway, is activated in human cancers with beta-catenin defects and promotes neoplastic transformation.
Cancer cell 2002;1(2):145-55.
2001: Takao Hinoi; M Tani; Peter C Lucas; Karel Caca; Rodney L Dunn; E Macri; Massimo Loda; Henry D Appelman; Kathleen R Cho; Eric R Fearon
Loss of CDX2 expression and microsatellite instability are prominent features of large cell minimally differentiated carcinomas of the colon.
The American journal of pathology 2001;159(6):2239-48.
2001: Rong Wu; Yali Zhai; Eric R Fearon; Kathleen R Cho
Diverse mechanisms of beta-catenin deregulation in ovarian endometrioid adenocarcinomas.
Cancer research 2001;61(22):8247-55.
2001: Thomas J Giordano; Kerby Shedden; Donald R Schwartz; Rork Kuick; Jeremy Taylor; N Lee; David E Misek; Joel K Greenson; Sharon L R Kardia; David G Beer; Gad Rennert; Kathleen R Cho; Stephen B Gruber; Eric R Fearon; Samir Hanash
Organ-specific molecular classification of primary lung, colon, and ovarian adenocarcinomas using gene expression profiles.
The American journal of pathology 2001;159(4):1231-8.
2001: Hideyo Ugai; H O Li; M Komatsu; H Tsutsui; J Song; T Shiga; Eric R Fearon; T Murata; Kazunari K Yokoyama
Interaction of Myc-associated zinc finger protein with DCC, the product of a tumor-suppressor gene, during the neural differentiation of P19 EC cells.
Biochemical and biophysical research communications 2001;286(5):1087-97.
2001: noriaki sunaga; Takashi Kohno; Frank T Kolligs; Eric R Fearon; R Saito; Jun Yokota
Constitutive activation of the Wnt signaling pathway by CTNNB1 (beta-catenin) mutations in a subset of human lung adenocarcinoma.
Genes, chromosomes & cancer 2001;30(3):316-21.
2000: Y Sun; Frank T Kolligs; M O Hottiger; R Mosavin; Eric R Fearon; Gary Nabel
Regulation of beta -catenin transformation by the p300 transcriptional coactivator.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(23):12613-8.
2000: Frank T Kolligs; B Kolligs; Karen M Hajra; Gang Hu; M Tani; Kathleen R Cho; Eric R Fearon
gamma-catenin is regulated by the APC tumor suppressor and its oncogenic activity is distinct from that of beta-catenin.
Genes & development 2000;14(11):1319-31.
2000: Seiyu Hosono; Isabelle Gross; Milton A English; Karen M Hajra; Eric R Fearon; Jonathan D Licht
E-cadherin is a WT1 target gene.
The Journal of biological chemistry 2000;275(15):10943-53.
2000: Eric R Fearon
BRCA1 and E-cadherin promoter hypermethylation and gene inactivation in cancer-association or mechanism?
Journal of the National Cancer Institute 2000;92(7):515-7.
2000: W Hilgers; J J Song; M Haye; Ralph Hruban; Scott E Kern; Eric R Fearon
Homozygous deletions inactivate DCC, but not MADH4/DPC4/SMAD4, in a subset of pancreatic and biliary cancers.
Genes, chromosomes & cancer 2000;27(4):353-7.
1999: Eric R Fearon
Cancer progression.
Current biology : CB 1999;9(23):R873-5.
1999: Karen M Hajra; X Ji; Eric R Fearon
Extinction of E-cadherin expression in breast cancer via a dominant repression pathway acting on proximal promoter elements.
Oncogene 1999;18(51):7274-9.
1999: Rong Wu; DC Connolly; X Ren; Eric R Fearon; Kathleen R Cho
Somatic mutations of the PPP2R1B candidate tumor suppressor gene at chromosome 11q23 are infrequent in ovarian carcinomas.
Neoplasia (New York, N.Y.) 1999;1(4):311-4.
1999: Frank T Kolligs; Gang Hu; Chi Dang; Eric R Fearon
Neoplastic transformation of RK3E by mutant beta-catenin requires deregulation of Tcf/Lef transcription but not activation of c-myc expression.
Molecular and cellular biology 1999;19(8):5696-706.
1999: Karel Caca; Frank T Kolligs; X Ji; M Hayes; J Qian; Alan Yahanda; D L Rimm; J Costa; Eric R Fearon
Beta- and gamma-catenin mutations, but not E-cadherin inactivation, underlie T-cell factor/lymphoid enhancer factor transcriptional deregulation in gastric and pancreatic cancer.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1999;10(6):369-76.
1999: David L Rimm; Karel Caca; G Hu; F B Harrison; Eric R Fearon
Frequent nuclear/cytoplasmic localization of beta-catenin without exon 3 mutations in malignant melanoma.
The American journal of pathology 1999;154(2):325-9.
1999: Eric R Fearon; Chi Dang
Cancer genetics: tumor suppressor meets oncogene.
Current biology : CB 1999;9(2):R62-5.
1999: Jeffrey A Meyerhardt; Karel Caca; B C Eckstrand; G Hu; Christoph Lengauer; S Banavali; A T Look; Eric R Fearon
Netrin-1: interaction with deleted in colorectal cancer (DCC) and alterations in brain tumors and neuroblastomas.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1999;10(1):35-42.
1999: Gang Hu; Eric R Fearon
Siah-1 N-terminal RING domain is required for proteolysis function, and C-terminal sequences regulate oligomerization and binding to target proteins.
Molecular and cellular biology 1999;19(1):724-32.
1998: Daniel A Haber; Eric R Fearon
The promise of cancer genetics.
Lancet 1998;351 Suppl 2():SII1-8.
1998: RA Ghoussoub; Deborah Dillon; Thomas G D'Aquila; EB Rimm; Eric R Fearon; David L Rimm
Expression of c-met is a strong independent prognostic factor in breast carcinoma.
Cancer 1998;82(8):1513-20.
1998: Deborah J Marsh; V Coulon; Kathryn L Lunetta; P Rocca-Serra; Patricia Dahia; Z Zheng; D Liaw; S Caron; B Duboué; A Y Lin; Andrea L Richardson; J M Bonnetblanc; J M Bressieux; A Cabarrot-Moreau; Agnès Chompret; L Demange; RA Eeles; A M Yahanda; Eric R Fearon; J P Fricker; RJ Gorlin; Shirley V Hodgson; S Huson; D Lacombe; Charis Eng
Mutation spectrum and genotype-phenotype analyses in Cowden disease and Bannayan-Zonana syndrome, two hamartoma syndromes with germline PTEN mutation.
Human molecular genetics 1998;7(3):507-15.
1998: Deborah Dillon; Thomas G D'Aquila; A B Reynolds; Eric R Fearon; David L Rimm
The expression of p120ctn protein in breast cancer is independent of alpha- and beta-catenin and E-cadherin.
The American journal of pathology 1998;152(1):75-82.
1997: G Hu; Y L Chung; Thomas W Glover; V Valentine; A T Look; Eric R Fearon
Characterization of human homologs of the Drosophila seven in absentia (sina) gene.
Genomics 1997;46(1):103-11.
1997: Eric R Fearon
Human cancer syndromes: clues to the origin and nature of cancer.
Science (New York, N.Y.) 1997;278(5340):1043-50.
1997: Gang Hu; S Zhang; Marc Vidal; J L Baer; T Xu; Eric R Fearon
Mammalian homologs of seven in absentia regulate DCC via the ubiquitin-proteasome pathway.
Genes & development 1997;11(20):2701-14.
1997: X Ji; A S Woodard; D L Rimm; Eric R Fearon
Transcriptional defects underlie loss of E-cadherin expression in breast cancer.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1997;8(7):773-8.
1997: Eric R Fearon
The smoking gun and the damage done: genetic alterations in the lungs of smokers.
Journal of the National Cancer Institute 1997;89(12):834-6.
1997: Kaikobad Irani; Y Xia; Jay L Zweier; STEVEN SOLLOTT; Channing J Der; Eric R Fearon; M Sundaresan; TOREN FINKEL; Pascal J Goldschmidt-Clermont
Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts.
Science (New York, N.Y.) 1997;275(5306):1649-52.
1997: Jeffrey A Meyerhardt; A T Look; S H Bigner; Eric R Fearon
Identification and characterization of neogenin, a DCC-related gene.
Oncogene 1997;14(10):1129-36.
1997: M Reyes-Mugica; K Rieger-Christ; H Ohgaki; B C Ekstrand; M Helie; G Kleinman; Alan Yahanda; Eric R Fearon; P Kleihues; Michael A Reale
Loss of DCC expression and glioma progression.
Cancer research 1997;57(3):382-6.
1996: D Shibata; Michael A Reale; Philip T Lavin; M Silverman; Eric R Fearon; Glenn Steele; J M Jessup; Massimo Loda; I C Summerhayes
The DCC protein and prognosis in colorectal cancer.
The New England journal of medicine 1996;335(23):1727-32.
1996: Eric R Fearon
DCC: is there a connection between tumorigenesis and cell guidance molecules?
Biochimica et biophysica acta 1996;1288(2):M17-23.
1996: Michael A Reale; Miguel Reyes-Mugica; W E Pierceall; M C Rubinstein; L Hedrick; Susan Cohn; A Nakagawara; G M Brodeur; Eric R Fearon
Loss of DCC expression in neuroblastoma is associated with disease dissemination.
Clinical cancer research : an official journal of the American Association for Cancer Research 1996;2(7):1097-102.
1996: Alan Heldman; D E Kandzari; R W Tucker; L E Crawford; Eric R Fearon; K S Koblan; Pascal J Goldschmidt-Clermont
EJ-Ras inhibits phospholipase C gamma 1 but not actin polymerization induced by platelet-derived growth factor-BB via phosphatidylinositol 3-kinase.
Circulation research 1996;78(2):312-21.
1996: Eric R Fearon
Colorectal cancer: molecular genetic studies and their future clinical applications.
Medical and pediatric oncology. Supplement 1996;1():35-40.
1995: B C Ekstrand; T A Mansfield; S H Bigner; Eric R Fearon
DCC expression is altered by multiple mechanisms in brain tumours.
Oncogene 1995;11(11):2393-402.
1995: W E Pierceall; Amy S Woodard; Jon S Morrow; David L Rimm; Eric R Fearon
Frequent alterations in E-cadherin and alpha- and beta-catenin expression in human breast cancer cell lines.
Oncogene 1995;11(7):1319-26.
1995: Eric R Fearon
Molecular genetics of colorectal cancer.
Annals of the New York Academy of Sciences 1995;768():101-10.
1995: Kathleen R Cho; Eric R Fearon
DCC: linking tumour suppressor genes and altered cell surface interactions in cancer?
European journal of cancer (Oxford, England : 1990) 1995;31A(7-8):1055-60.
1995: Kathleen R Cho; Eric R Fearon
DCC: linking tumor suppressor genes and altered cell surface interactions in cancer?
Current opinion in genetics & development 1995;5(1):72-8.
1995: Eric R Fearon; W E Pierceall
The deleted in colorectal cancer (DCC) gene: a candidate tumour suppressor gene encoding a cell surface protein with similarity to neural cell adhesion molecules.
Cancer surveys 1995;24():3-17.
1994: W E Pierceall; Michael A Reale; A F Candia; Christopher V E Wright; Kathleen R Cho; Eric R Fearon
Expression of a homologue of the deleted in colorectal cancer (DCC) gene in the nervous system of developing Xenopus embryos.
Developmental biology 1994;166(2):654-65.
1994: Michael A Reale; G Hu; A I Zafar; Robert H Getzenberg; S M Levine; Eric R Fearon
Expression and alternative splicing of the deleted in colorectal cancer (DCC) gene in normal and malignant tissues.
Cancer research 1994;54(16):4493-501.
1994: L Hedrick; Kathleen R Cho; Eric R Fearon; Tzyy-choou Wu; Kenneth W Kinzler; Bert Vogelstein
The DCC gene product in cellular differentiation and colorectal tumorigenesis.
Genes & development 1994;8(10):1174-83.
1994: W E Pierceall; Kathleen R Cho; Robert H Getzenberg; Michael A Reale; L Hedrick; Bert Vogelstein; Eric R Fearon
NIH3T3 cells expressing the deleted in colorectal cancer tumor suppressor gene product stimulate neurite outgrowth in rat PC12 pheochromocytoma cells.
The Journal of cell biology 1994;124(6):1017-27.
1994: Kathleen R Cho; J D Oliner; J W Simons; L Hedrick; Eric R Fearon; A C Preisinger; P Hedge; G A Silverman; Bert Vogelstein
The DCC gene: structural analysis and mutations in colorectal carcinomas.
Genomics 1994;19(3):525-31.
1994: Eric R Fearon
Molecular genetic studies of the adenoma-carcinoma sequence.
Advances in internal medicine 1994;39():123-47.
1994: Eric R Fearon; B C Ekstrand; G Hu; W E Pierceall; Michael A Reale; S H Bigner
Studies of the deleted in colorectal cancer gene in normal and neoplastic tissues.
Cold Spring Harbor symposia on quantitative biology 1994;59():637-43.
1993: Eric R Fearon
K-ras gene mutation as a pathogenetic and diagnostic marker in human cancer.
Journal of the National Cancer Institute 1993;85(24):1978-80.
1993: TOREN FINKEL; J Duc; Eric R Fearon; Chi Dang; Gordon F Tomaselli
Detection and modulation in vivo of helix-loop-helix protein-protein interactions.
The Journal of biological chemistry 1993;268(1):5-8.
1992: Eric R Fearon; TOREN FINKEL; Maura L Gillison; S P Kennedy; James F Casella; Gordon F Tomaselli; Jon S Morrow; Chi Dang
Karyoplasmic interaction selection strategy: a general strategy to detect protein-protein interactions in mammalian cells.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(17):7958-62.
1992: Eric R Fearon; P A Jones
Progressing toward a molecular description of colorectal cancer development.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1992;6(10):2783-90.
1992: Eric R Fearon
Genetic alterations underlying colorectal tumorigenesis.
Cancer surveys 1992;12():119-36.
1991: P J Parry; D Markie; Eric R Fearon; J M Nigro; Bert Vogelstein; W F Bodmer
PCR-based detection of two MspI polymorphic sites at D18S8.
Nucleic acids research 1991;19(24):6983.
1991: J M Nigro; Kathleen R Cho; Eric R Fearon; Scott E Kern; J M Ruppert; J D Oliner; Kenneth W Kinzler; Bert Vogelstein
Scrambled exons.
Cell 1991;64(3):607-13.
1991: Chi Dang; J Barrett; M Villa-Garcia; Linda M. Resar; Gregory Kato ; Eric R Fearon
Intracellular leucine zipper interactions suggest c-Myc hetero-oligomerization.
Molecular and cellular biology 1991;11(2):954-62.
1991: T Itaya; Eric R Fearon; T Fiesinger; B Hunt; Bert Vogelstein; P Frost
Immunogenicity of a non-class I MHC expressing murine tumor transfected with the influenza virus hemagglutinin or murine interleukin-2 genes.
Cancer immunology, immunotherapy : CII 1991;33(4):267-73.
1991: Eric R Fearon
A genetic basis for the multi-step pathway of colorectal tumorigenesis.
Princess Takamatsu symposia 1991;22():37-48.
1990: Philip W Hinds; C A Finlay; R S Quartin; S J Baker; Eric R Fearon; Bert Vogelstein; Arnold J Levine
Mutant p53 DNA clones from human colon carcinomas cooperate with ras in transforming primary rat cells: a comparison of the "hot spot" mutant phenotypes.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1990;1(12):571-80.
1990: S J Baker; Sanford Markowitz; Eric R Fearon; James Willson; Bert Vogelstein
Suppression of human colorectal carcinoma cell growth by wild-type p53.
Science (New York, N.Y.) 1990;249(4971):912-5.
1990: Jerry A Winkelstein; Eric R Fearon
Carrier detection of the X-linked primary immunodeficiency diseases using X-chromosome inactivation analysis.
The Journal of allergy and clinical immunology 1990;85(6):1090-7.
1990: Eric R Fearon; Bert Vogelstein
A genetic model for colorectal tumorigenesis.
Cell 1990;61(5):759-67.
1990: Eric R Fearon; Drew M Pardoll; T Itaya; P Golumbek; Hyam I Levitsky; J W Simons; H Karasuyama; Bert Vogelstein; P Frost
Interleukin-2 production by tumor cells bypasses T helper function in the generation of an antitumor response.
Cell 1990;60(3):397-403.
1990: Eric R Fearon; Kathleen R Cho; J M Nigro; Scott E Kern; J W Simons; J M Ruppert; Stanley R Hamilton; A C Preisinger; G Thomas; Kenneth W Kinzler
Identification of a chromosome 18q gene that is altered in colorectal cancers.
Science (New York, N.Y.) 1990;247(4938):49-56.
1989: Scott E Kern; Eric R Fearon; K W Tersmette; J P Enterline; M Leppert; Y Nakamura; Raymond White; Bert Vogelstein; Stanley R Hamilton
Clinical and pathological associations with allelic loss in colorectal carcinoma [corrected].
JAMA : the journal of the American Medical Association 1989;261(21):3099-103.
1989: Hans K Schackert; T Itaya; Gabriele Schackert; Eric R Fearon; Bert Vogelstein; P Frost
Systemic immunity against a murine colon tumor (CT-26) produced by immunization with syngeneic cells expressing a transfected viral gene product.
International journal of cancer. Journal international du cancer 1989;43(5):823-7.
1989: S J Baker; Eric R Fearon; J M Nigro; Stanley R Hamilton; A C Preisinger; J M Jessup; P vanTuinen; David Ledbetter; David Barker; Y Nakamura; Raymond White; Bert Vogelstein
Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas.
Science (New York, N.Y.) 1989;244(4901):217-21.
1989: Bert Vogelstein; Eric R Fearon; Scott E Kern; Stanley R Hamilton; A C Preisinger; Y Nakamura; Raymond White
Allelotype of colorectal carcinomas.
Science (New York, N.Y.) 1989;244(4901):207-11.
1988: Eric R Fearon; D B Kohn; Jerry A Winkelstein; Bert Vogelstein; R. Michael Blaese
Carrier detection in the Wiskott Aldrich syndrome.
Blood 1988;72(5):1735-9.
1988: Bert Vogelstein; Eric R Fearon; Stanley R Hamilton; Scott E Kern; A C Preisinger; M Leppert; Y Nakamura; Raymond White; A M Smits; J L Bos
Genetic alterations during colorectal-tumor development.
The New England journal of medicine 1988;319(9):525-32.
1988: Eric R Fearon; T Itaya; B Hunt; Bert Vogelstein; P Frost
Induction in a murine tumor of immunogenic tumor variants by transfection with a foreign gene.
Cancer research 1988;48(11):2975-80.
1987: Eric R Fearon; Stanley R Hamilton; Bert Vogelstein
Clonal analysis of human colorectal tumors.
Science (New York, N.Y.) 1987;238(4824):193-7.
1987: Bert Vogelstein; Eric R Fearon; Stanley R Hamilton; A C Preisinger; H F Willard; A M Michelson; A D Riggs; Stuart H Orkin
Clonal analysis using recombinant DNA probes from the X-chromosome.
Cancer research 1987;47(18):4806-13.
1987: Stephen B Baylin; Eric R Fearon; Bert Vogelstein; A de Bustros; Saul J Sharkis; P J Burke; S P Staal; Barry D Nelkin
Hypermethylation of the 5' region of the calcitonin gene is a property of human lymphoid and acute myeloid malignancies.
Blood 1987;70(2):412-7.
1987: J L Bos; Eric R Fearon; S R Hamilton; M Verlaan-de Vries; J H van Boom; A J van der Eb; Bert Vogelstein
Prevalence of ras gene mutations in human colorectal cancers.
Nature 1987;327(6120):293-7.
1987: Eric R Fearon; J A Winkelstein; Curt I Civin; Drew M Pardoll; Bert Vogelstein
Carrier detection in X-linked agammaglobulinemia by analysis of X-chromosome inactivation.
The New England journal of medicine 1987;316(8):427-31.
1986: Eric R Fearon; P J Burke; B A Zehnbauer; Bert Vogelstein; Charles Alan Schiffer
Differentiation of blast cells in acute nonlymphocytic leukemia.
The New England journal of medicine 1986;315(23):1488.
1986: Eric R Fearon; P J Burke; Charles Alan Schiffer; B A Zehnbauer; Bert Vogelstein
Differentiation of leukemia cells to polymorphonuclear leukocytes in patients with acute nonlymphocytic leukemia.
The New England journal of medicine 1986;315(1):15-24.
1985: Eric R Fearon; Andrew P Feinberg; S H Hamilton; Bert Vogelstein
Loss of genes on the short arm of chromosome 11 in bladder cancer.
Nature 1985;318(6044):377-80.
1985: Bert Vogelstein; Eric R Fearon; S R Hamilton; Andrew P Feinberg
Use of restriction fragment length polymorphisms to determine the clonal origin of human tumors.
Science (New York, N.Y.) 1985;227(4687):642-5.
1985: Eric R Fearon; R L Mallonee; J A Phillips; William E O'Brien; S W Brusilow; M W Adcock; L T Kirby
Genetic analysis of carbamyl phosphate synthetase I deficiency.
Human genetics 1985;70(3):207-10.
1984: Eric R Fearon; Bert Vogelstein; Andrew P Feinberg
Somatic deletion and duplication of genes on chromosome 11 in Wilms' tumours.
Nature 1984;309(5964):176-8.
1984: Eric R Fearon; S E Antonarakis; Deborah A Meyers; M A Levine
c-Ha-ras-1 oncogene lies between beta-globin and insulin loci on human chromosome 11p.
American journal of human genetics 1984;36(2):329-37.
1983: S E Antonarakis; J A Phillips; R L Mallonee; Haig Kazazian ; Eric R Fearon; P G Waber; H M Kronenberg; A Ullrich; Deborah A Meyers
Beta-globin locus is linked to the parathyroid hormone (PTH) locus and lies between the insulin and PTH loci in man.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(21):6615-9.
1983: E V Prochownik; S Antonarakis; K A Bauer; R D Rosenberg; Eric R Fearon; Stuart H Orkin
Molecular heterogeneity of inherited antithrombin III deficiency.
The New England journal of medicine 1983;308(26):1549-52.
1983: Eric R Fearon; Haig Kazazian ; P G Waber; J I Lee; S E Antonarakis; Stuart H Orkin; E F Vanin; P S Henthorn; Frank Grosveld; Alan F Scott; G R Buchanan
The entire beta-globin gene cluster is deleted in a form of gamma delta beta-thalassemia.
Blood 1983;61(6):1269-74.