Eric Fearon

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Fearon Eric R
PARsing the phrase "all in for Axin"- Wnt pathway targets in cancer.
Shackleton Mark; Quintana Elsa; Fearon Eric R; Morrison Sean J
Heterogeneity in cancer: cancer stem cells versus clonal evolution.
Vilar Eduardo; Mukherjee Bhramar; Kuick Rork; Raskin Leon; Misek David E; Taylor Jeremy M G; Giordano Thomas J; Hanash Samir M; Fearon Eric R; Rennert Gad; Gruber Stephen B
Gene expression patterns in mismatch repair-deficient colorectal cancers highlight the potential therapeutic role of inhibitors of the phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin pathway.

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All Publications

2009: Fearon Eric R
PARsing the phrase "all in for Axin"- Wnt pathway targets in cancer.
Cancer cell 2009;16(5):366-8.
2009: Shackleton Mark; Quintana Elsa; Fearon Eric R; Morrison Sean J
Heterogeneity in cancer: cancer stem cells versus clonal evolution.
Cell 2009;138(5):822-9.
2009: Vilar Eduardo; Mukherjee Bhramar; Kuick Rork; Raskin Leon; Misek David E; Taylor Jeremy M G; Giordano Thomas J; Hanash Samir M; Fearon Eric R; Rennert Gad; Gruber Stephen B
Gene expression patterns in mismatch repair-deficient colorectal cancers highlight the potential therapeutic role of inhibitors of the phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin pathway.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(8):2829-39.
2009: Wang Lidong; Heidt David G; Lee Cheong J; Yang Huibin; Logsdon Craig D; Zhang Lizhi; Fearon Eric R; Ljungman Mats; Simeone Diane M
Oncogenic function of ATDC in pancreatic cancer through Wnt pathway activation and beta-catenin stabilization.
Cancer cell 2009;15(3):207-19.
2009: Rowe R Grant; Li Xiao-Yan; Hu Yuexian; Saunders Thomas L; Virtanen Ismo; Garcia de Herreros Antonio; Becker Karl-Friedrich; Ingvarsen Signe; Engelholm Lars H; Bommer Guido T; Fearon Eric R; Weiss Stephen J
Mesenchymal cells reactivate Snail1 expression to drive three-dimensional invasion programs.
The Journal of cell biology 2009;184(3):399-408.
2009: Ji Qing; Hao Xinbao; Zhang Min; Tang Wenhua; Yang Meng; Li Ling; Xiang Debing; Desano Jeffrey T; Bommer Guido T; Fan Daiming; Fearon Eric R; Lawrence Theodore S; Xu Liang
MicroRNA miR-34 inhibits human pancreatic cancer tumor-initiating cells.
PloS one 2009;4(8):e6816.
2008: Sangha Navneet; Wu Rong; Kuick Rork; Powers Scott; Mu David; Fiander Diane; Yuen Kit; Katabuchi Hidetaka; Tashiro Hironori; Fearon Eric R; Cho Kathleen R
Neurofibromin 1 (NF1) defects are common in human ovarian serous carcinomas and co-occur with TP53 mutations.
Neoplasia (New York, N.Y.) 2008;10(12):1362-72, following 1372.
2008: Whiteman E L; Liu C-J; Fearon E R; Margolis B
The transcription factor snail represses Crumbs3 expression and disrupts apico-basal polarity complexes.
Oncogene 2008;27(27):3875-9.
2008: Akyol Aytekin; Hinoi Takao; Feng Ying; Bommer Guido T; Glaser Thomas M; Fearon Eric R
Generating somatic mosaicism with a Cre recombinase-microsatellite sequence transgene.
Nature methods 2008;5(3):231-3.
2008: Burstein Ezra; Fearon Eric R
Colitis and cancer: a tale of inflammatory cells and their cytokines.
The Journal of clinical investigation 2008;118(2):464-7.
2007: Zhai Yali; Kuick Rork; Nan Bin; Ota Ichiro; Weiss Stephen J; Trimble Cornelia L; Fearon Eric R; Cho Kathleen R
Gene expression analysis of preinvasive and invasive cervical squamous cell carcinomas identifies HOXC10 as a key mediator of invasion.
Cancer research 2007;67(21):10163-72.
2007: Hinoi Takao; Akyol Aytekin; Theisen Brian K; Ferguson David O; Greenson Joel K; Williams Bart O; Cho Kathleen R; Fearon Eric R
Mouse model of colonic adenoma-carcinoma progression based on somatic Apc inactivation.
Cancer research 2007;67(20):9721-30.
2007: Bommer Guido T; Gerin Isabelle; Feng Ying; Kaczorowski Andrew J; Kuick Rork; Love Robert E; Zhai Yali; Giordano Thomas J; Qin Zhaohui S; Moore Bethany B; MacDougald Ormond A; Cho Kathleen R; Fearon Eric R
p53-mediated activation of miRNA34 candidate tumor-suppressor genes.
Current biology : CB 2007;17(15):1298-307.
2007: Bommer Guido T; Fearon Eric R
Role of c-Myc in Apc mutant intestinal phenotype: case closed or time for a new beginning?
Cancer cell 2007;11(5):391-4.
2007: Wu Rong; Hendrix-Lucas Neali; Kuick Rork; Zhai Yali; Schwartz Donald R; Akyol Aytekin; Hanash Samir; Misek David E; Katabuchi Hidetaka; Williams Bart O; Fearon Eric R; Cho Kathleen R
Mouse model of human ovarian endometrioid adenocarcinoma based on somatic defects in the Wnt/beta-catenin and PI3K/Pten signaling pathways.
Cancer cell 2007;11(4):321-33.
2007: Feng Ying; Bommer Guido T; Zhai Yali; Akyol Aytekin; Hinoi Takao; Winer Ira; Lin Hua V; Cadigan Ken M; Cho Kathleen R; Fearon Eric R
Drosophila split ends homologue SHARP functions as a positive regulator of Wnt/beta-catenin/T-cell factor signaling in neoplastic transformation.
Cancer research 2007;67(2):482-91.
2006: Yook Jong In; Li Xiao-Yan; Ota Ichiro; Hu Casey; Kim Hyun Sil; Kim Nam Hee; Cha So Young; Ryu Joo Kyung; Choi Yoon Jung; Kim Jin; Fearon Eric R; Weiss Stephen J
A Wnt-Axin2-GSK3beta cascade regulates Snail1 activity in breast cancer cells.
Nature cell biology 2006;8(12):1398-406.
2006: Winer Ira S; Bommer Guido T; Gonik Nathan; Fearon Eric R
Lysine residues Lys-19 and Lys-49 of beta-catenin regulate its levels and function in T cell factor transcriptional activation and neoplastic transformation.
The Journal of biological chemistry 2006;281(36):26181-7.
2006: Hendrix Neali D; Wu Rong; Kuick Rork; Schwartz Donald R; Fearon Eric R; Cho Kathleen R
Fibroblast growth factor 9 has oncogenic activity and is a downstream target of Wnt signaling in ovarian endometrioid adenocarcinomas.
Cancer research 2006;66(3):1354-62.
2005: Rozek Laura S; Lipkin Steven M; Fearon Eric R; Hanash Samir; Giordano Thomas J; Greenson Joel K; Kuick Rork; Misek David E; Taylor Jeremy M G; Douglas Julie A; Rennert Gad; Gruber Stephen B
CDX2 polymorphisms, RNA expression, and risk of colorectal cancer.
Cancer research 2005;65(13):5488-92.
2005: Fearon Eric R; Cadigan Ken M
Cell biology. Wnt signaling glows with RNAi.
Science (New York, N.Y.) 2005;308(5723):801-3.
2005: Hinoi Takao; Gesina Galina; Akyol Aytekin; Kuick Rork; Hanash Samir; Giordano Thomas J; Gruber Stephen B; Fearon Eric R
CDX2-regulated expression of iron transport protein hephaestin in intestinal and colonic epithelium.
Gastroenterology 2005;128(4):946-61.
2005: Shedden Kerby A; Kshirsagar Malti P; Schwartz Donald R; Wu Rong; Yu Hongfeng; Misek David E; Hanash Samir; Katabuchi Hidetaka; Ellenson Lora Hedrick; Fearon Eric R; Cho Kathleen R
Histologic type, organ of origin, and Wnt pathway status: effect on gene expression in ovarian and uterine carcinomas.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(6):2123-31.
2005: Yook Jong In; Li Xiao-Yan; Ota Ichiro; Fearon Eric R; Weiss Stephen J
Wnt-dependent regulation of the E-cadherin repressor snail.
The Journal of biological chemistry 2005;280(12):11740-8.
2005: Bommer Guido T; Jäger Claudia; Dürr Eva-Maria; Baehs Sebastian; Eichhorst Sören T; Brabletz Thomas; Hu Gang; Fröhlich Thomas; Arnold Georg; Kress Dagmar C; Göke Burkhard; Fearon Eric R; Kolligs Frank T
DRO1, a gene down-regulated by oncogenes, mediates growth inhibition in colon and pancreatic cancer cells.
The Journal of biological chemistry 2005;280(9):7962-75.
2005: Shedden Kerby; Chen Wei; Kuick Rork; Ghosh Debashis; Macdonald James; Cho Kathleen R; Giordano Thomas J; Gruber Stephen B; Fearon Eric R; Taylor Jeremy M G; Hanash Samir
Comparison of seven methods for producing Affymetrix expression scores based on False Discovery Rates in disease profiling data.
BMC bioinformatics 2005;6():26.
2004: Li Chi-Ming; Kim Connie E; Margolin Adam A; Guo Meirong; Zhu Jimmy; Mason Jacqueline M; Hensle Terrence W; Murty Vundavalli V V S; Grundy Paul E; Fearon Eric R; D'Agati Vivette; Licht Jonathan D; Tycko Benjamin
CTNNB1 mutations and overexpression of Wnt/beta-catenin target genes in WT1-mutant Wilms' tumors.
The American journal of pathology 2004;165(6):1943-53.
2004: Li Weiquan; Lee Jeeyong; Vikis Haris G; Lee Seung-Hee; Liu Guofa; Aurandt Jennifer; Shen Tang-Long; Fearon Eric R; Guan Jun-Lin; Han Min; Rao Yi; Hong Kyonsoo; Guan Kun-Liang
Activation of FAK and Src are receptor-proximal events required for netrin signaling.
Nature neuroscience 2004;7(11):1213-21.
2004: Fearon Eric R; Cho Kathleen R
Cancer: cell survival guide.
Nature 2004;431(7004):35-6.
2004: Mehlen Patrick; Fearon Eric R
Role of the dependence receptor DCC in colorectal cancer pathogenesis.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2004;22(16):3420-8.
2004: Lipkin Steven M; Rozek Laura S; Rennert Gad; Yang Wei; Chen Peng-Chieh; Hacia Joseph; Hunt Nathan; Shin Brian; Fodor Steve; Kokoris Mark; Greenson Joel K; Fearon Eric; Lynch Henry; Collins Francis; Gruber Stephen B
The MLH1 D132H variant is associated with susceptibility to sporadic colorectal cancer.
Nature genetics 2004;36(7):694-9.
2004: Fearon Eric R
Defining the microsatellite instability phenotype in colorectal cancer through analysis of surrogate markers.
Cancer biology & therapy 2004;3(1):79-81.
2003: Feng Ying; Lee Nana; Fearon Eric R
TIP49 regulates beta-catenin-mediated neoplastic transformation and T-cell factor target gene induction via effects on chromatin remodeling.
Cancer research 2003;63(24):8726-34.
2003: Shedden Kerby A; Taylor Jeremy M G; Giordano Thomas J; Kuick Rork; Misek David E; Rennert Gad; Schwartz Donald R; Gruber Stephen B; Logsdon Craig; Simeone Diane; Kardia Sharon L R; Greenson Joel K; Cho Kathleen R; Beer David G; Fearon Eric R; Hanash Samir
Accurate molecular classification of human cancers based on gene expression using a simple classifier with a pathological tree-based framework.
The American journal of pathology 2003;163(5):1985-95.
2003: Hinoi Takao; Loda Massimo; Fearon Eric R
Silencing of CDX2 expression in colon cancer via a dominant repression pathway.
The Journal of biological chemistry 2003;278(45):44608-16.
2003: Kim Paul J; Plescia Janet; Clevers Hans; Fearon Eric R; Altieri Dario C
Survivin and molecular pathogenesis of colorectal cancer.
Lancet 2003;362(9379):205-9.
2003: Schwartz Donald R; Wu Rong; Kardia Sharon L R; Levin Albert M; Huang Chiang-Ching; Shedden Kerby A; Kuick Rork; Misek David E; Hanash Samir M; Taylor Jeremy M G; Reed Heather; Hendrix Neali; Zhai Yali; Fearon Eric R; Cho Kathleen R
Novel candidate targets of beta-catenin/T-cell factor signaling identified by gene expression profiling of ovarian endometrioid adenocarcinomas.
Cancer research 2003;63(11):2913-22.
2003: Van Mater David; Kolligs Frank T; Dlugosz Andrzej A; Fearon Eric R
Transient activation of beta -catenin signaling in cutaneous keratinocytes is sufficient to trigger the active growth phase of the hair cycle in mice.
Genes & development 2003;17(10):1219-24.
2003: Wu Rong; Lin Lin; Beer David G; Ellenson Lora H; Lamb Barbara J; Rouillard Jean-Marie; Kuick Rork; Hanash Samir; Schwartz Donald R; Fearon Eric R; Cho Kathleen R
Amplification and overexpression of the L-MYC proto-oncogene in ovarian carcinomas.
The American journal of pathology 2003;162(5):1603-10.
2003: Fearon Eric R
Connecting estrogen receptor function, transcriptional repression, and E-cadherin expression in breast cancer.
Cancer cell 2003;3(4):307-10.
2002: Hinoi Takao; Lucas Peter C; Kuick Rork; Hanash Samir; Cho Kathleen R; Fearon Eric R
CDX2 regulates liver intestine-cadherin expression in normal and malignant colon epithelium and intestinal metaplasia.
Gastroenterology 2002;123(5):1565-77.
2002: Schwartz Donald R; Kardia Sharon L R; Shedden Kerby A; Kuick Rork; Michailidis George; Taylor Jeremy M G; Misek David E; Wu Rong; Zhai Yali; Darrah Danielle M; Reed Heather; Ellenson Lora H; Giordano Thomas J; Fearon Eric R; Hanash Samir M; Cho Kathleen R
Gene expression in ovarian cancer reflects both morphology and biological behavior, distinguishing clear cell from other poor-prognosis ovarian carcinomas.
Cancer research 2002;62(16):4722-9.
2002: Qualtrough D; Hinoi T; Fearon E; Paraskeva C
Expression of CDX2 in normal and neoplastic human colon tissue and during differentiation of an in vitro model system.
Gut 2002;51(2):184-90.
2002: Hajra Karen M; Fearon Eric R
Cadherin and catenin alterations in human cancer.
Genes, chromosomes & cancer 2002;34(3):255-68.
2002: Leung Janet Y; Kolligs Frank T; Wu Rong; Zhai Yali; Kuick Rork; Hanash Samir; Cho Kathleen R; Fearon Eric R
Activation of AXIN2 expression by beta-catenin-T cell factor. A feedback repressor pathway regulating Wnt signaling.
The Journal of biological chemistry 2002;277(24):21657-65.
2002: Zhai Yali; Wu Rong; Schwartz Donald R; Darrah Danielle; Reed Heather; Kolligs Frank T; Nieman Marvin T; Fearon Eric R; Cho Kathleen R
Role of beta-catenin/T-cell factor-regulated genes in ovarian endometrioid adenocarcinomas.
The American journal of pathology 2002;160(4):1229-38.
2002: Kolligs Frank T; Nieman Marvin T; Winer Ira; Hu Gang; Van Mater David; Feng Ying; Smith Ian M; Wu Rong; Zhai Yali; Cho Kathleen R; Fearon Eric R
ITF-2, a downstream target of the Wnt/TCF pathway, is activated in human cancers with beta-catenin defects and promotes neoplastic transformation.
Cancer cell 2002;1(2):145-55.
2002: Hajra Karen M; Chen David Y-S; Fearon Eric R
The SLUG zinc-finger protein represses E-cadherin in breast cancer.
Cancer research 2002;62(6):1613-8.
2001: Hinoi T; Tani M; Lucas P C; Caca K; Dunn R L; Macri E; Loda M; Appelman H D; Cho K R; Fearon E R
Loss of CDX2 expression and microsatellite instability are prominent features of large cell minimally differentiated carcinomas of the colon.
The American journal of pathology 2001;159(6):2239-48.
2001: Wu R; Zhai Y; Fearon E R; Cho K R
Diverse mechanisms of beta-catenin deregulation in ovarian endometrioid adenocarcinomas.
Cancer research 2001;61(22):8247-55.
2001: Giordano T J; Shedden K A; Schwartz D R; Kuick R; Taylor J M; Lee N; Misek D E; Greenson J K; Kardia S L; Beer D G; Rennert G; Cho K R; Gruber S B; Fearon E R; Hanash S
Organ-specific molecular classification of primary lung, colon, and ovarian adenocarcinomas using gene expression profiles.
The American journal of pathology 2001;159(4):1231-8.
2001: Ugai H; Li H O; Komatsu M; Tsutsui H; Song J; Shiga T; Fearon E; Murata T; Yokoyama K K
Interaction of Myc-associated zinc finger protein with DCC, the product of a tumor-suppressor gene, during the neural differentiation of P19 EC cells.
Biochemical and biophysical research communications 2001;286(5):1087-97.
2001: Sunaga N; Kohno T; Kolligs F T; Fearon E R; Saito R; Yokota J
Constitutive activation of the Wnt signaling pathway by CTNNB1 (beta-catenin) mutations in a subset of human lung adenocarcinoma.
Genes, chromosomes & cancer 2001;30(3):316-21.
2000: Sun Y; Kolligs F T; Hottiger M O; Mosavin R; Fearon E R; Nabel G J
Regulation of beta -catenin transformation by the p300 transcriptional coactivator.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(23):12613-8.
2000: Kolligs F T; Kolligs B; Hajra K M; Hu G; Tani M; Cho K R; Fearon E R
gamma-catenin is regulated by the APC tumor suppressor and its oncogenic activity is distinct from that of beta-catenin.
Genes & development 2000;14(11):1319-31.
2000: Hosono S; Gross I; English M A; Hajra K M; Fearon E R; Licht J D
E-cadherin is a WT1 target gene.
The Journal of biological chemistry 2000;275(15):10943-53.
2000: Fearon E R
BRCA1 and E-cadherin promoter hypermethylation and gene inactivation in cancer-association or mechanism?
Journal of the National Cancer Institute 2000;92(7):515-7.
2000: Hilgers W; Song J J; Haye M; Hruban R R; Kern S E; Fearon E R
Homozygous deletions inactivate DCC, but not MADH4/DPC4/SMAD4, in a subset of pancreatic and biliary cancers.
Genes, chromosomes & cancer 2000;27(4):353-7.
1999: Fearon E R
Cancer progression.
Current biology : CB 1999;9(23):R873-5.
1999: Hajra K M; Ji X; Fearon E R
Extinction of E-cadherin expression in breast cancer via a dominant repression pathway acting on proximal promoter elements.
Oncogene 1999;18(51):7274-9.
1999: Wu R; Connolly D C; Ren X; Fearon E R; Cho K R
Somatic mutations of the PPP2R1B candidate tumor suppressor gene at chromosome 11q23 are infrequent in ovarian carcinomas.
Neoplasia (New York, N.Y.) 1999;1(4):311-4.
1999: Kolligs F T; Hu G; Dang C V; Fearon E R
Neoplastic transformation of RK3E by mutant beta-catenin requires deregulation of Tcf/Lef transcription but not activation of c-myc expression.
Molecular and cellular biology 1999;19(8):5696-706.
1999: Caca K; Kolligs F T; Ji X; Hayes M; Qian J; Yahanda A; Rimm D L; Costa J; Fearon E R
Beta- and gamma-catenin mutations, but not E-cadherin inactivation, underlie T-cell factor/lymphoid enhancer factor transcriptional deregulation in gastric and pancreatic cancer.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1999;10(6):369-76.
1999: Rimm D L; Caca K; Hu G; Harrison F B; Fearon E R
Frequent nuclear/cytoplasmic localization of beta-catenin without exon 3 mutations in malignant melanoma.
The American journal of pathology 1999;154(2):325-9.
1999: Fearon E R; Dang C V
Cancer genetics: tumor suppressor meets oncogene.
Current biology : CB 1999;9(2):R62-5.
1999: Meyerhardt J A; Caca K; Eckstrand B C; Hu G; Lengauer C; Banavali S; Look A T; Fearon E R
Netrin-1: interaction with deleted in colorectal cancer (DCC) and alterations in brain tumors and neuroblastomas.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1999;10(1):35-42.
1999: Hu G; Fearon E R
Siah-1 N-terminal RING domain is required for proteolysis function, and C-terminal sequences regulate oligomerization and binding to target proteins.
Molecular and cellular biology 1999;19(1):724-32.
1998: Haber D A; Fearon E R
The promise of cancer genetics.
Lancet 1998;351 Suppl 2():SII1-8.
1998: Ghoussoub R A; Dillon D A; D'Aquila T; Rimm E B; Fearon E R; Rimm D L
Expression of c-met is a strong independent prognostic factor in breast carcinoma.
Cancer 1998;82(8):1513-20.
1998: Marsh D J; Coulon V; Lunetta K L; Rocca-Serra P; Dahia P L; Zheng Z; Liaw D; Caron S; Duboué B; Lin A Y; Richardson A L; Bonnetblanc J M; Bressieux J M; Cabarrot-Moreau A; Chompret A; Demange L; Eeles R A; Yahanda A M; Fearon E R; Fricker J P; Gorlin R J; Hodgson S V; Huson S; Lacombe D; Eng C
Mutation spectrum and genotype-phenotype analyses in Cowden disease and Bannayan-Zonana syndrome, two hamartoma syndromes with germline PTEN mutation.
Human molecular genetics 1998;7(3):507-15.
1998: Dillon D A; D'Aquila T; Reynolds A B; Fearon E R; Rimm D L
The expression of p120ctn protein in breast cancer is independent of alpha- and beta-catenin and E-cadherin.
The American journal of pathology 1998;152(1):75-82.
1997: Hu G; Chung Y L; Glover T; Valentine V; Look A T; Fearon E R
Characterization of human homologs of the Drosophila seven in absentia (sina) gene.
Genomics 1997;46(1):103-11.
1997: Fearon E R
Human cancer syndromes: clues to the origin and nature of cancer.
Science (New York, N.Y.) 1997;278(5340):1043-50.
1997: Hu G; Zhang S; Vidal M; Baer J L; Xu T; Fearon E R
Mammalian homologs of seven in absentia regulate DCC via the ubiquitin-proteasome pathway.
Genes & development 1997;11(20):2701-14.
1997: Ji X; Woodard A S; Rimm D L; Fearon E R
Transcriptional defects underlie loss of E-cadherin expression in breast cancer.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1997;8(7):773-8.
1997: Fearon E R
The smoking gun and the damage done: genetic alterations in the lungs of smokers.
Journal of the National Cancer Institute 1997;89(12):834-6.
1997: Meyerhardt J A; Look A T; Bigner S H; Fearon E R
Identification and characterization of neogenin, a DCC-related gene.
Oncogene 1997;14(10):1129-36.
1997: Irani K; Xia Y; Zweier J L; Sollott S J; Der C J; Fearon E R; Sundaresan M; Finkel T; Goldschmidt-Clermont P J
Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts.
Science (New York, N.Y.) 1997;275(5306):1649-52.
1997: Reyes-Mugica M; Rieger-Christ K; Ohgaki H; Ekstrand B C; Helie M; Kleinman G; Yahanda A; Fearon E R; Kleihues P; Reale M A
Loss of DCC expression and glioma progression.
Cancer research 1997;57(3):382-6.
1996: Shibata D; Reale M A; Lavin P; Silverman M; Fearon E R; Steele G; Jessup J M; Loda M; Summerhayes I C
The DCC protein and prognosis in colorectal cancer.
The New England journal of medicine 1996;335(23):1727-32.
1996: Fearon E R
DCC: is there a connection between tumorigenesis and cell guidance molecules?
Biochimica et biophysica acta 1996;1288(2):M17-23.
1996: Reale M A; Reyes-Mugica M; Pierceall W E; Rubinstein M C; Hedrick L; Cohn S L; Nakagawara A; Brodeur G M; Fearon E R
Loss of DCC expression in neuroblastoma is associated with disease dissemination.
Clinical cancer research : an official journal of the American Association for Cancer Research 1996;2(7):1097-102.
1996: Heldman A W; Kandzari D E; Tucker R W; Crawford L E; Fearon E R; Koblan K S; Goldschmidt-Clermont P J
EJ-Ras inhibits phospholipase C gamma 1 but not actin polymerization induced by platelet-derived growth factor-BB via phosphatidylinositol 3-kinase.
Circulation research 1996;78(2):312-21.
1996: Fearon E R
Colorectal cancer: molecular genetic studies and their future clinical applications.
Medical and pediatric oncology. Supplement 1996;1():35-40.
1995: Ekstrand B C; Mansfield T A; Bigner S H; Fearon E R
DCC expression is altered by multiple mechanisms in brain tumours.
Oncogene 1995;11(11):2393-402.
1995: Pierceall W E; Woodard A S; Morrow J S; Rimm D; Fearon E R
Frequent alterations in E-cadherin and alpha- and beta-catenin expression in human breast cancer cell lines.
Oncogene 1995;11(7):1319-26.
1995: Fearon E R
Molecular genetics of colorectal cancer.
Annals of the New York Academy of Sciences 1995;768():101-10.
1995: Cho K R; Fearon E R
DCC: linking tumour suppressor genes and altered cell surface interactions in cancer?
European journal of cancer (Oxford, England : 1990) 1995;31A(7-8):1055-60.
1995: Cho K R; Fearon E R
DCC: linking tumor suppressor genes and altered cell surface interactions in cancer?
Current opinion in genetics & development 1995;5(1):72-8.
1995: Fearon E R; Pierceall W E
The deleted in colorectal cancer (DCC) gene: a candidate tumour suppressor gene encoding a cell surface protein with similarity to neural cell adhesion molecules.
Cancer surveys 1995;24():3-17.
1994: Pierceall W E; Reale M A; Candia A F; Wright C V; Cho K R; Fearon E R
Expression of a homologue of the deleted in colorectal cancer (DCC) gene in the nervous system of developing Xenopus embryos.
Developmental biology 1994;166(2):654-65.
1994: Reale M A; Hu G; Zafar A I; Getzenberg R H; Levine S M; Fearon E R
Expression and alternative splicing of the deleted in colorectal cancer (DCC) gene in normal and malignant tissues.
Cancer research 1994;54(16):4493-501.
1994: Hedrick L; Cho K R; Fearon E R; Wu T C; Kinzler K W; Vogelstein B
The DCC gene product in cellular differentiation and colorectal tumorigenesis.
Genes & development 1994;8(10):1174-83.
1994: Pierceall W E; Cho K R; Getzenberg R H; Reale M A; Hedrick L; Vogelstein B; Fearon E R
NIH3T3 cells expressing the deleted in colorectal cancer tumor suppressor gene product stimulate neurite outgrowth in rat PC12 pheochromocytoma cells.
The Journal of cell biology 1994;124(6):1017-27.
1994: Cho K R; Oliner J D; Simons J W; Hedrick L; Fearon E R; Preisinger A C; Hedge P; Silverman G A; Vogelstein B
The DCC gene: structural analysis and mutations in colorectal carcinomas.
Genomics 1994;19(3):525-31.
1994: Fearon E R
Molecular genetic studies of the adenoma-carcinoma sequence.
Advances in internal medicine 1994;39():123-47.
1994: Fearon E R; Ekstrand B C; Hu G; Pierceall W E; Reale M A; Bigner S H
Studies of the deleted in colorectal cancer gene in normal and neoplastic tissues.
Cold Spring Harbor symposia on quantitative biology 1994;59():637-43.
1993: Fearon E R
K-ras gene mutation as a pathogenetic and diagnostic marker in human cancer.
Journal of the National Cancer Institute 1993;85(24):1978-80.
1993: Finkel T; Duc J; Fearon E R; Dang C V; Tomaselli G F
Detection and modulation in vivo of helix-loop-helix protein-protein interactions.
The Journal of biological chemistry 1993;268(1):5-8.
1992: Fearon E R; Finkel T; Gillison M L; Kennedy S P; Casella J F; Tomaselli G F; Morrow J S; Van Dang C
Karyoplasmic interaction selection strategy: a general strategy to detect protein-protein interactions in mammalian cells.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(17):7958-62.
1992: Fearon E R; Jones P A
Progressing toward a molecular description of colorectal cancer development.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1992;6(10):2783-90.
1992: Fearon E R
Genetic alterations underlying colorectal tumorigenesis.
Cancer surveys 1992;12():119-36.
1991: Parry P J; Markie D; Fearon E R; Nigro J M; Vogelstein B; Bodmer W F
PCR-based detection of two MspI polymorphic sites at D18S8.
Nucleic acids research 1991;19(24):6983.
1991: Nigro J M; Cho K R; Fearon E R; Kern S E; Ruppert J M; Oliner J D; Kinzler K W; Vogelstein B
Scrambled exons.
Cell 1991;64(3):607-13.
1991: Dang C V; Barrett J; Villa-Garcia M; Resar L M; Kato G J; Fearon E R
Intracellular leucine zipper interactions suggest c-Myc hetero-oligomerization.
Molecular and cellular biology 1991;11(2):954-62.
1991: Itaya T; Fearon E; Fiesinger T; Hunt B; Vogelstein B; Frost P
Immunogenicity of a non-class I MHC expressing murine tumor transfected with the influenza virus hemagglutinin or murine interleukin-2 genes.
Cancer immunology, immunotherapy : CII 1991;33(4):267-73.
1991: Fearon E R
A genetic basis for the multi-step pathway of colorectal tumorigenesis.
Princess Takamatsu symposia 1991;22():37-48.
1990: Hinds P W; Finlay C A; Quartin R S; Baker S J; Fearon E R; Vogelstein B; Levine A J
Mutant p53 DNA clones from human colon carcinomas cooperate with ras in transforming primary rat cells: a comparison of the "hot spot" mutant phenotypes.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1990;1(12):571-80.
1990: Baker S J; Markowitz S; Fearon E R; Willson J K; Vogelstein B
Suppression of human colorectal carcinoma cell growth by wild-type p53.
Science (New York, N.Y.) 1990;249(4971):912-5.
1990: Winkelstein J A; Fearon E
Carrier detection of the X-linked primary immunodeficiency diseases using X-chromosome inactivation analysis.
The Journal of allergy and clinical immunology 1990;85(6):1090-7.
1990: Fearon E R; Vogelstein B
A genetic model for colorectal tumorigenesis.
Cell 1990;61(5):759-67.
1990: Fearon E R; Pardoll D M; Itaya T; Golumbek P; Levitsky H I; Simons J W; Karasuyama H; Vogelstein B; Frost P
Interleukin-2 production by tumor cells bypasses T helper function in the generation of an antitumor response.
Cell 1990;60(3):397-403.
1990: Fearon E R; Cho K R; Nigro J M; Kern S E; Simons J W; Ruppert J M; Hamilton S R; Preisinger A C; Thomas G; Kinzler K W
Identification of a chromosome 18q gene that is altered in colorectal cancers.
Science (New York, N.Y.) 1990;247(4938):49-56.
1989: Kern S E; Fearon E R; Tersmette K W; Enterline J P; Leppert M; Nakamura Y; White R; Vogelstein B; Hamilton S R
Clinical and pathological associations with allelic loss in colorectal carcinoma [corrected]
JAMA : the journal of the American Medical Association 1989;261(21):3099-103.
1989: Schackert H K; Itaya T; Schackert G; Fearon E; Vogelstein B; Frost P
Systemic immunity against a murine colon tumor (CT-26) produced by immunization with syngeneic cells expressing a transfected viral gene product.
International journal of cancer. Journal international du cancer 1989;43(5):823-7.
1989: Baker S J; Fearon E R; Nigro J M; Hamilton S R; Preisinger A C; Jessup J M; vanTuinen P; Ledbetter D H; Barker D F; Nakamura Y; White R; Vogelstein B
Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas.
Science (New York, N.Y.) 1989;244(4901):217-21.
1989: Vogelstein B; Fearon E R; Kern S E; Hamilton S R; Preisinger A C; Nakamura Y; White R
Allelotype of colorectal carcinomas.
Science (New York, N.Y.) 1989;244(4901):207-11.
1988: Fearon E R; Kohn D B; Winkelstein J A; Vogelstein B; Blaese R M
Carrier detection in the Wiskott Aldrich syndrome.
Blood 1988;72(5):1735-9.
1988: Vogelstein B; Fearon E R; Hamilton S R; Kern S E; Preisinger A C; Leppert M; Nakamura Y; White R; Smits A M; Bos J L
Genetic alterations during colorectal-tumor development.
The New England journal of medicine 1988;319(9):525-32.
1988: Fearon E R; Itaya T; Hunt B; Vogelstein B; Frost P
Induction in a murine tumor of immunogenic tumor variants by transfection with a foreign gene.
Cancer research 1988;48(11):2975-80.
1987: Fearon E R; Hamilton S R; Vogelstein B
Clonal analysis of human colorectal tumors.
Science (New York, N.Y.) 1987;238(4824):193-7.
1987: Vogelstein B; Fearon E R; Hamilton S R; Preisinger A C; Willard H F; Michelson A M; Riggs A D; Orkin S H
Clonal analysis using recombinant DNA probes from the X-chromosome.
Cancer research 1987;47(18):4806-13.
1987: Baylin S B; Fearon E R; Vogelstein B; de Bustros A; Sharkis S J; Burke P J; Staal S P; Nelkin B D
Hypermethylation of the 5' region of the calcitonin gene is a property of human lymphoid and acute myeloid malignancies.
Blood 1987;70(2):412-7.
1987: Bos J L; Fearon E R; Hamilton S R; Verlaan-de Vries M; van Boom J H; van der Eb A J; Vogelstein B
Prevalence of ras gene mutations in human colorectal cancers.
Nature 1987;327(6120):293-7.
1987: Fearon E R; Winkelstein J A; Civin C I; Pardoll D M; Vogelstein B
Carrier detection in X-linked agammaglobulinemia by analysis of X-chromosome inactivation.
The New England journal of medicine 1987;316(8):427-31.
1986: Fearon E R; Burke P J; Zehnbauer B A; Vogelstein B; Schiffer C A
Differentiation of blast cells in acute nonlymphocytic leukemia.
The New England journal of medicine 1986;315(23):1488.
1986: Fearon E R; Burke P J; Schiffer C A; Zehnbauer B A; Vogelstein B
Differentiation of leukemia cells to polymorphonuclear leukocytes in patients with acute nonlymphocytic leukemia.
The New England journal of medicine 1986;315(1):15-24.
1985: Fearon E R; Feinberg A P; Hamilton S H; Vogelstein B
Loss of genes on the short arm of chromosome 11 in bladder cancer.
Nature 1985;318(6044):377-80.
1985: Vogelstein B; Fearon E R; Hamilton S R; Feinberg A P
Use of restriction fragment length polymorphisms to determine the clonal origin of human tumors.
Science (New York, N.Y.) 1985;227(4687):642-5.
1985: Fearon E R; Mallonee R L; Phillips J A; O'Brien W E; Brusilow S W; Adcock M W; Kirby L T
Genetic analysis of carbamyl phosphate synthetase I deficiency.
Human genetics 1985;70(3):207-10.
1984: Fearon E R; Vogelstein B; Feinberg A P
Somatic deletion and duplication of genes on chromosome 11 in Wilms' tumours.
Nature 1984;309(5964):176-8.
1984: Fearon E R; Antonarakis S E; Meyers D A; Levine M A
c-Ha-ras-1 oncogene lies between beta-globin and insulin loci on human chromosome 11p.
American journal of human genetics 1984;36(2):329-37.
1983: Antonarakis S E; Phillips J A; Mallonee R L; Kazazian H H; Fearon E R; Waber P G; Kronenberg H M; Ullrich A; Meyers D A
Beta-globin locus is linked to the parathyroid hormone (PTH) locus and lies between the insulin and PTH loci in man.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(21):6615-9.
1983: Fearon E R; Kazazian H H; Waber P G; Lee J I; Antonarakis S E; Orkin S H; Vanin E F; Henthorn P S; Grosveld F G; Scott A F; Buchanan G R
The entire beta-globin gene cluster is deleted in a form of gamma delta beta-thalassemia.
Blood 1983;61(6):1269-74.
1983: Prochownik E V; Antonarakis S; Bauer K A; Rosenberg R D; Fearon E R; Orkin S H
Molecular heterogeneity of inherited antithrombin III deficiency.
The New England journal of medicine 1983;308(26):1549-52.

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