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Massimo Federici

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Rossella Menghini; Viviana Casagrande; Loredana Fiorentino; Renato Lauro; Massimo Federici
The role of ADAM17 in metabolic inflammation.
Loredana Fiorentino; Loreto Gesualdo; Rama Khokha; Davide Lauro; Renato Lauro; Valentina Marchetti; Maria Mavilio; Rossella Menghini; Stefano Menini; Paola Pontrelli; Giuseppe Pugliese; Domenico Accili; Ivan Arisi; Viviana Casagrande; Michele Cavalera; Francesca Conserva; Mara D'Onofrio; Marta Fabrizi; Massimo Federici
Loss of TIMP3 underlies diabetic nephropathy via FoxO1/STAT1 interplay.
Alfonso Bellia; Monica D'Adamo; Giulia Donadel; Massimo Federici; Caterina Garcovich; Paolo Gentileschi; Davide Lauro; Renato Lauro; Mauro Lombardo; Manfredi Tesauro; Paolo Sbraccia
Serum 25-hydroxyvitamin D levels are inversely associated with systemic inflammation in severe obese subjects.

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All Publications

2013: Rossella Menghini; Viviana Casagrande; Loredana Fiorentino; Renato Lauro; Massimo Federici
The role of ADAM17 in metabolic inflammation.
Atherosclerosis 2013;228(1):12-7.
2013: Loredana Fiorentino; Loreto Gesualdo; Rama Khokha; Davide Lauro; Renato Lauro; Valentina Marchetti; Maria Mavilio; Rossella Menghini; Stefano Menini; Paola Pontrelli; Giuseppe Pugliese; Domenico Accili; Ivan Arisi; Viviana Casagrande; Michele Cavalera; Francesca Conserva; Mara D'Onofrio; Marta Fabrizi; Massimo Federici
Loss of TIMP3 underlies diabetic nephropathy via FoxO1/STAT1 interplay.
EMBO molecular medicine 2013;5(3):441-55.
2013: Alfonso Bellia; Monica D'Adamo; Giulia Donadel; Massimo Federici; Caterina Garcovich; Paolo Gentileschi; Davide Lauro; Renato Lauro; Mauro Lombardo; Manfredi Tesauro; Paolo Sbraccia
Serum 25-hydroxyvitamin D levels are inversely associated with systemic inflammation in severe obese subjects.
Internal and emergency medicine 2013;8(1):33-40.
2013: Simonetta Bacci; Roberto Baratta; Agostino Consoli; Massimiliano Copetti; Rosa Di Paola; Natalia Di Pietro; Sara Di Silvestre; Alessandro Doria; Massimo Federici; Lucia Frittitta; Renato Lauro; Lorenzo Malatino; Francesca Mallamaci; Luana Mercuri; Eleonora Morini; Assunta Pandolfi; Fabio Pellegrini; Sabrina Prudente; Stefano Rizza; Belinda Spoto; Alessandra Testa; Giovanni Tripepi; Yuan-Yuan Zhang; Carmine Zoccali; Vincenzo Trischitta
Joint effect of insulin signaling genes on cardiovascular events and on whole body and endothelial insulin resistance.
Atherosclerosis 2013;226(1):140-5.
2012: Alfonso Bellia; Monica D'Adamo; Giulia Donadel; Massimo Federici; Paolo Gentileschi; Valeria Guglielmi; Davide Lauro; Renato Lauro; Mauro Lombardo; Giorgia Marinoni; Paolo Sbraccia
Parathyroid hormone and insulin resistance in distinct phenotypes of severe obesity: a cross-sectional analysis in middle-aged men and premenopausal women.
The Journal of clinical endocrinology and metabolism 2012;97(12):4724-32.
2012: Ivan Monteleone; Francesco Pallone; Angelamaria Rizzo; Massimiliano Sarra; Francesca Zorzi; Viviana Casagrande; Michele Cavalera; Massimo Federici; Eleonora Franzè; Renato Lauro; Thomas T MacDonald; Giovanni Monteleone
Tissue inhibitor of metalloproteinase-3 regulates inflammation in human and mouse intestine.
Gastroenterology 2012;143(5):1277-87.e1-4.
2012: Alessandro Rufini; richard tomasini; Arianna Marino; Gerry Melino; Maria Victoria Niklison-Chirou; David Dinsdale; Massimo Federici; Isaac S Harris; Satoshi Inoue; Richard A Knight; Tak Wah Mak
TAp73 depletion accelerates aging through metabolic dysregulation.
Genes & development 2012;26(18):2009-14.
2012: Robert Stoehr; Massimo Federici
Do stem cells cause aging-related intimal medial thickening?
Atherosclerosis 2012;224(1):39-40.
2012: Stefano Rizza; Francesco Romeo; Alessia Valentini; Marina Cardellini; Massimiliano Copetti; Arnaldo Ippoliti; Davide Lauro; Renato Lauro; Alessio Luzi; E Martelli; Chiara Pecchioli; Fabio Pellegrini; Ottavia Porzio; Massimo Federici
Atherosclerosis severity but not undiagnosed diabetes predicts new cardiovascular events of subjects in secondary cardiovascular prevention.
Atherosclerosis 2012;223(2):448-53.
2012: Alfonso Bellia; Carmine Cardillo; Giulia Donadel; Rossella Fabiano; Massimo Federici; Marco Felice Lombardo; Michael Quon; Stefano Rizza; Paolo Sbraccia; Manfredi Tesauro; Katia Andreadi; Davide Lauro
Deterioration of glucose homeostasis in type 2 diabetic patients one year after beginning of statins therapy.
Atherosclerosis 2012;223(1):197-203.
2012: Rossella Menghini; Stefano Menini; Giuseppe Pugliese; Paolo Sbraccia; Orazio Schillaci; Andrea Urbani; Paolo Gentileschi; Marta Letizia Hribal; Davide Lauro; Renato Lauro; Arianna Marino; Valeria Marzano; Viviana Casagrande; Massimo Federici
TIMP3 overexpression in macrophages protects from insulin resistance, adipose inflammation, and nonalcoholic fatty liver disease in mice.
Diabetes 2012;61(2):454-62.
2011: Marina Cardellini; Iris Cardolini; Rossella D'Alfonso; Francesca Davato; Paolo Gentileschi; Davide Lauro; Renato Lauro; Alessio Luzi; Maria Adelaide Marini; Rossella Menghini; Ottavia Porzio; Stefano Rizza; Paolo Sbraccia; Massimo Federici
Decreased IRS2 and TIMP3 expression in monocytes from offspring of type 2 diabetic patients is correlated with insulin resistance and increased intima-media thickness.
Diabetes 2011;60(12):3265-70.
2011: Marco F Lombardo; Rita Nano; Massimo Federici; Davide Lauro; Renato Lauro; Barbara Bartolini; Federico Bertuzzi; Luca Bova; Barbara Capuani; Fabiana De Angelis; Giulia Donadel
Human placental lactogen (hPL-A) activates signaling pathways linked to cell survival and improves insulin secretion in human pancreatic islets.
Islets 2011;3(5):250-8.
2011: Rossella Menghini; Massimo Federici
MicroPPARticle in atherosclerosis: guilty or innocent by-standers?
Atherosclerosis 2011;218(1):21-2.
2011: Mariuca Vasa-Nicotera; Ai Li Yang; Massimiliano Agostini; Hailan Chen; Richard A Knight; Christian Mahè; Gerry Melino; Rossella Menghini; Gaelle Saintigny; Paola Tucci; Massimo Federici
miR-146a is modulated in human endothelial cell with aging.
Atherosclerosis 2011;217(2):326-30.
2011: Carla Iacobini; Stefano Menini; Carlo Ricci; Angela Scipioni; Laura Salvi; Samantha Cordone; Francesca Delucchi; Matteo Serino; Massimo Federici; Flavia Pricci; Claudia Blasetti Fantauzzi; Giuseppe Pugliese
Galectin-3 ablation protects mice from diet-induced NASH: a major scavenging role for galectin-3 in liver.
Journal of hepatology 2011;54(5):975-83.
2011: Stefano Rizza; Massimo Federici
Cytokines and metabolic syndrome: the perfect storm for arterial aging.
Atherosclerosis 2011;215(2):284-5.
2011: Stefano Rizza; Marina Cardellini; Ottavia Porzio; Chiara Pecchioli; Alessia Savo; Iris Cardolini; Nicoletta Senese; Davide Lauro; Paolo Sbraccia; Renato Lauro; Massimo Federici
Pioglitazone improves endothelial and adipose tissue dysfunction in pre-diabetic CAD subjects.
Atherosclerosis 2011;215(1):180-3.
2011: Massimo Federici; Rossella Menghini
sPLA2: linking atherosclerosis to aneurysm progression.
Atherosclerosis 2011;214(1):41-2.
2010: Valeria Guglielmi; Monica D'Adamo; Maria Rosaria D'Apice; Alfonso Bellia; Davide Lauro; Massimo Federici; Renato Lauro; Giuseppe Novelli; Paolo Sbraccia
Elbow deformities in a patient with mandibuloacral dysplasia type A.
American journal of medical genetics. Part A 2010;152A(11):2711-3.
2010: Stefano Rizza; Marina Cardellini; E Martelli; Ottavia Porzio; Chiara Pecchioli; Antonio Nicolucci; Nikolaus Marx; Davide Lauro; Arnaldo Ippoliti; Franco Romeo; Renato Lauro; Massimo Federici
Occult impaired glucose regulation in patients with atherosclerosis is associated to the number of affected vascular districts and inflammation.
Atherosclerosis 2010;212(1):316-20.
2010: Stefano Rizza; Fabrizio Gigli; Angelica Galli; Barbara Micchelini; Davide Lauro; Renato Lauro; Massimo Federici
Adiponectin isoforms in elderly patients with or without coronary artery disease.
Journal of the American Geriatrics Society 2010;58(4):702-6.
2010: Loredana Fiorentino; Alessia Vivanti; Michele Cavalera; Valeria Marzano; Maurizio Ronci; Marta Fabrizi; Stefano Menini; Giuseppe Pugliese; Rossella Menghini; Rama Khokha; Renato Lauro; Andrea Urbani; Massimo Federici
Increased tumor necrosis factor alpha-converting enzyme activity induces insulin resistance and hepatosteatosis in mice.
Hepatology (Baltimore, Md.) 2010;51(1):103-10.
2010: Paola Rogliani; Giacomo Curradi; Marco Mura; Davide Lauro; Massimo Federici; Angelica Galli; Cesare Saltini; Mario Cazzola
Metabolic syndrome and risk of pulmonary involvement.
Respiratory medicine 2010;104(1):47-51.
2009: Rossella Menghini; Viviana Casagrande; Marina Cardellini; E Martelli; Alessandro Terrinoni; Francesca Amati; Mariuca Vasa-Nicotera; Arnaldo Ippoliti; Giuseppe Novelli; Gerry Melino; Renato Lauro; Massimo Federici
MicroRNA 217 modulates endothelial cell senescence via silent information regulator 1.
Circulation 2009;120(15):1524-32.
2009: Marina Cardellini; Rossella Menghini; E Martelli; Viviana Casagrande; Arianna Marino; Stefano Rizza; Ottavia Porzio; Alessandro Mauriello; Anna Solini; Arnaldo Ippoliti; Renato Lauro; Franco Folli; Massimo Federici
TIMP3 is reduced in atherosclerotic plaques from subjects with type 2 diabetes and increased by SirT1.
Diabetes 2009;58(10):2396-401.
2009: Stefano Rizza; Manfredi Tesauro; Carmine Cardillo; Angelica Galli; Micaela Iantorno; Fabrizio Gigli; Paolo Sbraccia; Massimo Federici; Michael Quon; Davide Lauro
Fish oil supplementation improves endothelial function in normoglycemic offspring of patients with type 2 diabetes.
Atherosclerosis 2009;206(2):569-74.
2009: A Bellia; Emiliano Giardina; D Lauro; Manfredi Tesauro; Gaetana Di Fede; G Cusumano; Massimo Federici; Giovam Battista Rini; Giuseppe Novelli; Renato Lauro; Paolo Sbraccia
"The Linosa Study": epidemiological and heritability data of the metabolic syndrome in a Caucasian genetic isolate.
Nutrition, metabolism, and cardiovascular diseases : NMCD 2009;19(7):455-61.
2009: Carla Iacobini; Stefano Menini; Carlo Ricci; Angela Scipioni; Viola Sansoni; Samantha Cordone; Maurizio Taurino; Matteo Serino; Giuseppe Marano; Massimo Federici; Flavia Pricci; Giuseppe Pugliese
Accelerated lipid-induced atherogenesis in galectin-3-deficient mice: role of lipoxidation via receptor-mediated mechanisms.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(6):831-6.
2009: Rossella Menghini; Stefano Menini; Roberta Amoruso; Loredana Fiorentino; Viviana Casagrande; Valeria Marzano; Federica Tornei; Pierfrancesco Bertucci; Carla Iacobini; Matteo Serino; Ottavia Porzio; Marta Letizia Hribal; Franco Folli; Rama Khokha; Andrea Urbani; Renato Lauro; Giuseppe Pugliese; Massimo Federici
Tissue inhibitor of metalloproteinase 3 deficiency causes hepatic steatosis and adipose tissue inflammation in mice.
Gastroenterology 2009;136(2):663-72.e4.
2009: Stefano Rizza; Fabrizio Clementi; Ottavia Porzio; Marina Cardellini; Alessia Savo; Matteo Serino; Gaetano Chiricolo; Francesco Romeo; Renato Lauro; Massimo Federici
Adiponectin isoforms are not associated with the severity of coronary atherosclerosis but with undiagnosed diabetes in patients affected by stable CAD.
Nutrition, metabolism, and cardiovascular diseases : NMCD 2009;19(1):54-60.
2008: ANGELO SCUTERI; Manfredi Tesauro; Stefano Rizza; Micaela Iantorno; Massimo Federici; Davide Lauro; Umberto Campia; Mario Turriziani; Angelo Fusco; Giulio Cocciolillo; Renato Lauro
Endothelial function and arterial stiffness in normotensive normoglycemic first-degree relatives of diabetic patients are independent of the metabolic syndrome.
Nutrition, metabolism, and cardiovascular diseases : NMCD 2008;18(5):349-56.
2008: Claudia Consoli; E Martelli; Monica D'Adamo; Rossella Menghini; Diego Arcelli; Ottavia Porzio; Assunta Pandolfi; Giuseppe R Pistolese; Agostino Consoli; Renato Lauro; Arnaldo Ippoliti; Massimo Federici
Insulin resistance affects gene expression in endothelium.
Arteriosclerosis, thrombosis, and vascular biology 2008;28(2):e7-9.
2007: Mirella Fiorito; Isabella Torrente; Salvatore De Cosmo; Valentina Guida; Alessia Colosimo; Sabrina Prudente; Elisabetta Flex; Rossella Menghini; Roberto Miccoli; Giuseppe Penno; Fabio Pellegrini; Vittorio Tassi; Massimo Federici; Vincenzo Trischitta; Bruno Dallapiccola
Interaction of DIO2 T92A and PPARgamma2 P12A polymorphisms in the modulation of metabolic syndrome.
Obesity (Silver Spring, Md.) 2007;15(12):2889-95.
2007: Ottavia Porzio; Ornella Massa; Veronica Cunsolo; C Colombo; M Malaponti; Federico Bertuzzi; T Hansen; A Johansen; Oluf Pedersen; Franco Meschi; Alessandro Terrinoni; Gerry Melino; Massimo Federici; N Decarlo; Michele Menicagli; Daniela Campani; Piero Marchetti; M Ferdaoussi; philippe froguel; Giorgio Federici; Martine Vaxillaire; Fabrizio Barbetti
Missense mutations in the TGM2 gene encoding transglutaminase 2 are found in patients with early-onset type 2 diabetes. Mutation in brief no. 982. Online.
Human mutation 2007;28(11):1150.
2007: Matteo Serino; Rossella Menghini; Loredana Fiorentino; Roberta Amoruso; Alessandro Mauriello; Davide Lauro; Paolo Sbraccia; Marta Letizia Hribal; Renato Lauro; Massimo Federici
Mice heterozygous for tumor necrosis factor-alpha converting enzyme are protected from obesity-induced insulin resistance and diabetes.
Diabetes 2007;56(10):2541-6.
2007: Manfredi Tesauro; Stefano Rizza; Micaela Iantorno; Umberto Campia; Carmine Cardillo; Davide Lauro; ROBERTO LEO; Mario Turriziani; Giulio Cesare Cocciolillo; Angelo Fusco; Julio A Panza; ANGELO SCUTERI; Massimo Federici; Renato Lauro; Michael Quon
Vascular, metabolic, and inflammatory abnormalities in normoglycemic offspring of patients with type 2 diabetes mellitus.
Metabolism: clinical and experimental 2007;56(3):413-9.
2007: Marina Cardellini; Maria Adelaide Marini; Simona Frontoni; Marta Letizia Hribal; Francesco Andreozzi; Francesco Perticone; Massimo Federici; Davide Lauro; Giorgio Sesti
Carotid artery intima-media thickness is associated with insulin-mediated glucose disposal in nondiabetic normotensive offspring of type 2 diabetic patients.
American journal of physiology. Endocrinology and metabolism 2007;292(1):E347-52.
2006: Valentina Marchetti; Rossella Menghini; Stefano Rizza; Alessia Vivanti; Tiziana Feccia; Davide Lauro; Akiyoshi Fukamizu; Renato Lauro; Massimo Federici
Benfotiamine counteracts glucose toxicity effects on endothelial progenitor cell differentiation via Akt/FoxO signaling.
Diabetes 2006;55(8):2231-7.
2006: Stefano Rizza; Manfredi Tesauro; Marina Cardellini; Rossella Menghini; Alfonso Bellia; Maria Adelaide Marini; Davide Lauro; Paolo Sbraccia; Giorgio Sesti; Renato Lauro; Massimo Federici
Insulin resistance and increased intimal medial thickness in glucose tolerant offspring of type 2 diabetic subjects carrying the D298D genotype of endothelial nitric oxide synthase.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(2):431-2.
2005: Massimo Federici; Marta Letizia Hribal; Rossella Menghini; Hiroko Kanno; Valentina Marchetti; Ottavia Porzio; Susan W Sunnarborg; Stefano Rizza; Matteo Serino; Veronica Cunsolo; Davide Lauro; Alessandro Mauriello; David S Smookler; Paolo Sbraccia; Giorgio Sesti; David C Lee; Rama Khokha; Domenico Accili; Renato Lauro
Timp3 deficiency in insulin receptor-haploinsufficient mice promotes diabetes and vascular inflammation via increased TNF-alpha.
The Journal of clinical investigation 2005;115(12):3494-505.
2005: Rossella Menghini; Valentina Marchetti; Marina Cardellini; Marta Letizia Hribal; Alessandro Mauriello; Davide Lauro; Paolo Sbraccia; Renato Lauro; Massimo Federici
Phosphorylation of GATA2 by Akt increases adipose tissue differentiation and reduces adipose tissue-related inflammation: a novel pathway linking obesity to atherosclerosis.
Circulation 2005;111(15):1946-53.
2005: Giorgio Sesti; Angela Sciacqua; Marina Cardellini; Maria Adelaide Marini; Raffaele Maio; Marco Vatrano; Elena Succurro; Renato Lauro; Massimo Federici; Francesco Perticone
Plasma concentration of IGF-I is independently associated with insulin sensitivity in subjects with different degrees of glucose tolerance.
Diabetes care 2005;28(1):120-5.
2004: Francesco Perticone; Angela Sciacqua; Angela Scozzafava; Giorgio Ventura; Emanuela Laratta; Arturo Pujia; Massimo Federici; Renato Lauro; Giorgio Sesti
Impaired endothelial function in never-treated hypertensive subjects carrying the Arg972 polymorphism in the insulin receptor substrate-1 gene.
The Journal of clinical endocrinology and metabolism 2004;89(7):3606-9.
2004: Monica D'Adamo; Lucia Perego; Marina Cardellini; Maria Adelaide Marini; Simona Frontoni; Francesco Andreozzi; Angela Sciacqua; Davide Lauro; Paolo Sbraccia; Massimo Federici; Michele Paganelli; Antonio E Pontiroli; Renato Lauro; Francesco Perticone; Franco Folli; Giorgio Sesti
The -866A/A genotype in the promoter of the human uncoupling protein 2 gene is associated with insulin resistance and increased risk of type 2 diabetes.
Diabetes 2004;53(7):1905-10.
2004: Giorgio Sesti; Maria Alelaide Marini; Marina Cardellini; Angela Sciacqua; Simona Frontoni; Francesco Andreozzi; Concetta Irace; Davide Lauro; Agostino Gnasso; Massimo Federici; Francesco Perticone; Renato Lauro
The Arg972 variant in insulin receptor substrate-1 is associated with an increased risk of secondary failure to sulfonylurea in patients with type 2 diabetes.
Diabetes care 2004;27(6):1394-8.
2004: Cristina D'Alessandris; Francesco Andreozzi; Massimo Federici; Marina Cardellini; Antonio Brunetti; Marco Ranalli; SILVIA DEL GUERRA; Davide Lauro; Stefano Del Prato; Piero Marchetti; Renato Lauro; Giorgio Sesti
Increased O-glycosylation of insulin signaling proteins results in their impaired activation and enhanced susceptibility to apoptosis in pancreatic beta-cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(9):959-61.
2004: Francesco Andreozzi; Cristina D'Alessandris; Massimo Federici; Emanuela Laratta; SILVIA DEL GUERRA; Stefano Del Prato; Piero Marchetti; Renato Lauro; Francesco Perticone; Giorgio Sesti
Activation of the hexosamine pathway leads to phosphorylation of insulin receptor substrate-1 on Ser307 and Ser612 and impairs the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin insulin biosynthetic pathway in RIN pancreatic beta-cells.
Endocrinology 2004;145(6):2845-57.
2004: Massimo Federici
The strange case of G972R IRS-1 variant and diabetes. Do type 1 and type 2 diabetes share common genes?
Molecular genetics and metabolism 2004;81(4):261-2.
2004: Massimo Federici; Assunta Pandolfi; Elena A De Filippis; Giuliana Pellegrini; Rossella Menghini; Davide Lauro; Marina Cardellini; Mario Romano; Giorgio Sesti; Renato Lauro; Agostino Consoli
G972R IRS-1 variant impairs insulin regulation of endothelial nitric oxide synthase in cultured human endothelial cells.
Circulation 2004;109(3):399-405.
2003: Maria Adelaide Marini; Simona Frontoni; Davide Mineo; Daniela Bracaglia; Marina Cardellini; Pierluigi De Nicolais; Alessandra Baroni; Rossella D'Alfonso; Michela Perna; Davide Lauro; Massimo Federici; stefano gambardella; Renato Lauro; Giorgio Sesti
The Arg972 variant in insulin receptor substrate-1 is associated with an atherogenic profile in offspring of type 2 diabetic patients.
The Journal of clinical endocrinology and metabolism 2003;88(7):3368-71.
2003: Carlo Serra; Massimo Federici; Angela Maria Buongiorno; MI Senni; Stefania Morelli; E Segratella; M Pascuccio; Cecilia Tiveron; Enrico Mattei; Laura Tatangelo; Renato Lauro; Mario Molinaro; Andrea Giaccari; Marina Bouché
Transgenic mice with dominant negative PKC-theta in skeletal muscle: a new model of insulin resistance and obesity.
Journal of cellular physiology 2003;196(1):89-97.
2003: Marta Letizia Hribal; Lucia Perego; Sarah Lovari; Francesco Andreozzi; Rossella Menghini; Carla Perego; Giovanna Finzi; Luciana Usellini; Claudia Placidi; Carlo Capella; Valeria Guzzi; Davide Lauro; Federico Bertuzzi; Alberto M Davalli; Guido Pozza; Antonio E Pontiroli; Massimo Federici; Renato Lauro; Antonio Brunetti; Franco Folli; Giorgio Sesti
Chronic hyperglycemia impairs insulin secretion by affecting insulin receptor expression, splicing, and signaling in RIN beta cell line and human islets of Langerhans.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(10):1340-2.
2003: Giorgio Sesti; Marina Cardellini; Maria Adelaide Marini; Simona Frontoni; Monica D'Adamo; SILVIA DEL GUERRA; Davide Lauro; Pierluigi De Nicolais; Paolo Sbraccia; Stefano Del Prato; stefano gambardella; Massimo Federici; Piero Marchetti; Renato Lauro
A common polymorphism in the promoter of UCP2 contributes to the variation in insulin secretion in glucose-tolerant subjects.
Diabetes 2003;52(5):1280-3.
2003: Massimo Federici; Antonio Petrone; Ottavia Porzio; Carla Bizzarri; Davide Lauro; Rossella D'Alfonso; Ippolita Patera; Marco Cappa; Lorenza Nisticò; Marco Giorgio Baroni; Giorgio Sesti; Umberto Di Mario; Renato Lauro; Raffaella Buzzetti
The Gly972-->Arg IRS-1 variant is associated with type 1 diabetes in continental Italy.
Diabetes 2003;52(3):887-90.
2003: Rossella D'Alfonso; Maria Adelaide Marini; Lucia Frittitta; Roberto Sorge; Simona Frontoni; Ottavia Porzio; Luisa Marina Mariani; Davide Lauro; stefano gambardella; Vincenzo Trischitta; Massimo Federici; Renato Lauro; Giorgio Sesti
Polymorphisms of the insulin receptor substrate-2 in patients with type 2 diabetes.
The Journal of clinical endocrinology and metabolism 2003;88(1):317-22.
2002: Francesca Bernassola; Massimo Federici; Marco Corazzari; Alessandro Terrinoni; Marta Letizia Hribal; Vincenzo de Laurenzi; Marco Ranalli; Ornella Massa; Giorgio Sesti; W H Irwin McLean; Gennaro Citro; Fabrizio Barbetti; Gerry Melino
Role of transglutaminase 2 in glucose tolerance: knockout mice studies and a putative mutation in a MODY patient.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(11):1371-8.
2002: Paolo Sbraccia; Monica D'Adamo; Frida Leonetti; Angela Maria Buongiorno; Gianfranco Silecchia; Maria Sole Basso; Guido Tamburrano; Davide Lauro; Massimo Federici; Nicola Di Daniele; Renato Lauro
Relationship between plasma free fatty acids and uncoupling protein-3 gene expression in skeletal muscle of obese subjects: in vitro evidence of a causal link.
Clinical endocrinology 2002;57(2):199-207.
2002: Giuseppe Novelli; Antoine Muchir; Federica Sangiuolo; Anne Helbling-Leclerc; Maria Rosaria D'Apice; Catherine Massart; Francesca Capon; Paolo Sbraccia; Massimo Federici; Renato Lauro; Cosimo Tudisco; Rosanna Pallotta; Gioacchino Scarano; Bruno Dallapiccola; Luciano Merlini; Gisèle Bonne
Mandibuloacral dysplasia is caused by a mutation in LMNA-encoding lamin A/C.
American journal of human genetics 2002;71(2):426-31.
2002: Massimo Federici; Rossella Menghini; Alessandro Mauriello; Marta Letizia Hribal; Francesca Ferrelli; Davide Lauro; Paolo Sbraccia; Luigi Giusto Spagnoli; Giorgio Sesti; Renato Lauro
Insulin-dependent activation of endothelial nitric oxide synthase is impaired by O-linked glycosylation modification of signaling proteins in human coronary endothelial cells.
Circulation 2002;106(4):466-72.
2002: Lorenza Nisticò; Gabriele Giorgi; Mara Giordano; Andrea Galgani; Antonio Petrone; Sandra D'Alfonso; Massimo Federici; Umberto Di Mario; Paolo Pozzilli; Raffaella Buzzetti; Isabella Cascino
IL12B polymorphism and type 1 diabetes in the Italian population: a case-control study.
Diabetes 2002;51(5):1649-50.
2001: D Pierucci; Simona Cicconi; PAOLO BONINI; F Ferrelli; D Pastore; Claudia Matteucci; Lorella Marselli; Piero Marchetti; Frédéric Ris; Philippe A Halban; José Oberholzer; Massimo Federici; Federico Cozzolino; Renato Lauro; P Borboni; Lionel N J-L Marlier
NGF-withdrawal induces apoptosis in pancreatic beta cells in vitro.
Diabetologia 2001;44(10):1281-95.
2001: Giorgio Sesti; Massimo Federici; Marta Letizia Hribal; Davide Lauro; Paolo Sbraccia; Renato Lauro
Defects of the insulin receptor substrate (IRS) system in human metabolic disorders.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(12):2099-111.
2001: Giorgio Sesti; Massimo Federici; Davide Lauro; Paolo Sbraccia; Renato Lauro
Molecular mechanism of insulin resistance in type 2 diabetes mellitus: role of the insulin receptor variant forms.
Diabetes/metabolism research and reviews 2001;17(5):363-73.
2001: Massimo Federici; Marta Letizia Hribal; Lucia Perego; Marco Ranalli; Z Caradonna; C Perego; Luciana Usellini; Rita Nano; PAOLO BONINI; Federico Bertuzzi; Lionel N J-L Marlier; Alberto M Davalli; O Carandente; Antonio E Pontiroli; Gerry Melino; Piero Marchetti; Renato Lauro; Giorgio Sesti; Franco Folli
High glucose causes apoptosis in cultured human pancreatic islets of Langerhans: a potential role for regulation of specific Bcl family genes toward an apoptotic cell death program.
Diabetes 2001;50(6):1290-301.
2001: Marta Letizia Hribal; Rossella D'Alfonso; B Giovannone; Davide Lauro; Y Y Liu; P Borboni; Massimo Federici; Renato Lauro; Giorgio Sesti
The sulfonylurea glimepiride regulates intracellular routing of the insulin-receptor complexes through their interaction with specific protein kinase C isoforms.
Molecular pharmacology 2001;59(2):322-30.
2001: Massimo Federici; Marta Letizia Hribal; Marco Ranalli; Lorella Marselli; Ottavia Porzio; Davide Lauro; P Borboni; Renato Lauro; Piero Marchetti; Gerry Melino; Giorgio Sesti
The common Arg972 polymorphism in insulin receptor substrate-1 causes apoptosis of human pancreatic islets.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(1):22-24.
2000: B Giovannone; lucia scaldaferri; Massimo Federici; Ottavia Porzio; Davide Lauro; Angelo Fusco; Paolo Sbraccia; P Borboni; Renato Lauro; Giorgio Sesti
Insulin receptor substrate (IRS) transduction system: distinct and overlapping signaling potential.
Diabetes/metabolism research and reviews 2000;16(6):434-41.
2000: Marta Letizia Hribal; Massimo Federici; Ottavia Porzio; Davide Lauro; P Borboni; Domenico Accili; Renato Lauro; Giorgio Sesti
The Gly-->Arg972 amino acid polymorphism in insulin receptor substrate-1 affects glucose metabolism in skeletal muscle cells.
The Journal of clinical endocrinology and metabolism 2000;85(5):2004-13.
1999: Massimo Federici; Andrea Giaccari; Marta Letizia Hribal; B Giovannone; Davide Lauro; L Morviducci; L Pastore; Guido Tamburrano; Renato Lauro; Giorgio Sesti
Evidence for glucose/hexosamine in vivo regulation of insulin/IGF-I hybrid receptor assembly.
Diabetes 1999;48(12):2277-85.
1999: P Borboni; Ottavia Porzio; D Pierucci; Simona Cicconi; Roberta Magnaterra; Massimo Federici; Giorgio Sesti; Davide Lauro; Velia D'Agata; Sebastiano Cavallaro; Lionel N J-L Marlier
Molecular and functional characterization of pituitary adenylate cyclase-activating polypeptide (PACAP-38)/vasoactive intestinal polypeptide receptors in pancreatic beta-cells and effects of PACAP-38 on components of the insulin secretory system.
Endocrinology 1999;140(12):5530-7.
1999: Ottavia Porzio; Massimo Federici; Marta Letizia Hribal; Davide Lauro; Domenico Accili; Renato Lauro; P Borboni; Giorgio Sesti
The Gly972-->Arg amino acid polymorphism in IRS-1 impairs insulin secretion in pancreatic beta cells.
The Journal of clinical investigation 1999;104(3):357-64.
1999: Ottavia Porzio; Lionel N J-L Marlier; Massimo Federici; Marta Letizia Hribal; Roberta Magnaterra; Davide Lauro; Angelo Fusco; Giorgio Sesti; P Borboni
GLUT2 and glucokinase expression is coordinately regulated by sulfonylurea.
Molecular and cellular endocrinology 1999;153(1-2):155-61.
1998: Massimo Federici; Ottavia Porzio; Davide Lauro; P Borboni; B Giovannone; L Zucaro; Marta Letizia Hribal; Giorgio Sesti
Increased abundance of insulin/insulin-like growth factor-I hybrid receptors in skeletal muscle of obese subjects is correlated with in vivo insulin sensitivity.
The Journal of clinical endocrinology and metabolism 1998;83(8):2911-5.
1998: Massimo Federici; Davide Lauro; Monica D'Adamo; B Giovannone; Ottavia Porzio; M Mellozzi; Guido Tamburrano; Paolo Sbraccia; Giorgio Sesti
Expression of insulin/IGF-I hybrid receptors is increased in skeletal muscle of patients with chronic primary hyperinsulinemia.
Diabetes 1998;47(1):87-92.
1997: Massimo Federici; Ottavia Porzio; L Zucaro; B Giovannone; P Borboni; MA Marini; Davide Lauro; Giorgio Sesti
Increased abundance of insulin/IGF-I hybrid receptors in adipose tissue from NIDDM patients.
Molecular and cellular endocrinology 1997;135(1):41-7.
1997: Massimo Federici; Ottavia Porzio; L Zucaro; Angelo Fusco; P Borboni; Davide Lauro; Giorgio Sesti
Distribution of insulin/insulin-like growth factor-I hybrid receptors in human tissues.
Molecular and cellular endocrinology 1997;129(2):121-6.
1996: Massimo Federici; L Zucaro; Ottavia Porzio; Renato Massoud; P Borboni; Davide Lauro; Giorgio Sesti
Increased expression of insulin/insulin-like growth factor-I hybrid receptors in skeletal muscle of noninsulin-dependent diabetes mellitus subjects.
The Journal of clinical investigation 1996;98(12):2887-93.
1996: H Valensise; Yong-Yu Liu; Massimo Federici; Davide Lauro; D Dell'anna; C Romanini; Giorgio Sesti
Increased expression of low-affinity insulin receptor isoform and insulin/insulin-like growth factor-I hybrid receptors in term placenta from insulin-resistant women with gestational hypertension.
Diabetologia 1996;39(8):952-60.
1996: Giorgio Sesti; R D'Alfonso; M D Vargas Punti; A N Tullio; Yong-Yu Liu; Massimo Federici; P Borboni; MA Marini; Renato Lauro; Angelo Fusco
Delayed intracellular dissociation of the insulin-receptor complex impairs receptor recycling and insulin processing in cultured Epstein-Barr virus-transformed lymphocytes from insulin-resistant subjects.
Diabetologia 1996;39(3):289-95.