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Roland Feifel

Research Profile

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Chemicals & Drugs

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Mouse
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Publications

TOP 3
Laszlo Revesz; Achim Schlapbach; Reiner Aichholz; Roland Feifel; Stuart Hawtin; Richard Heng; Peter Hiestand; Wolfgang Jahnke; Guido Koch; Markus Kroemer; Henrik Möbitz; Clemens Scheufler; Juraj Velcicky; Christine Huppertz
In vivo and in vitro SAR of tetracyclic MAPKAP-K2 (MK2) inhibitors. Part I.
Laszlo Revesz; Achim Schlapbach; Reiner Aichholz; Janet Dawson; Roland Feifel; Stuart Hawtin; Amanda Littlewood-Evans; Guido Koch; Markus Kroemer; Henrik Möbitz; Clemens Scheufler; Juraj Velcicky; Christine Huppertz
In vivo and in vitro SAR of tetracyclic MAPKAP-K2 (MK2) inhibitors. Part II.
Juraj Velcicky; Roland Feifel; Stuart Hawtin; Richard Heng; Christine Huppertz; Guido Koch; Markus Kroemer; Henrik Moebitz; Laszlo Revesz; Clemens Scheufler; Achim Schlapbach
Novel 3-aminopyrazole inhibitors of MK-2 discovered by scaffold hopping strategy.

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All Publications

2010: Laszlo Revesz; Achim Schlapbach; Reiner Aichholz; Roland Feifel; Stuart Hawtin; Richard Heng; Peter Hiestand; Wolfgang Jahnke; Guido Koch; Markus Kroemer; Henrik Möbitz; Clemens Scheufler; Juraj Velcicky; Christine Huppertz
In vivo and in vitro SAR of tetracyclic MAPKAP-K2 (MK2) inhibitors. Part I.
Bioorganic & medicinal chemistry letters 2010;20(15):4715-8.
2010: Laszlo Revesz; Achim Schlapbach; Reiner Aichholz; Janet Dawson; Roland Feifel; Stuart Hawtin; Amanda Littlewood-Evans; Guido Koch; Markus Kroemer; Henrik Möbitz; Clemens Scheufler; Juraj Velcicky; Christine Huppertz
In vivo and in vitro SAR of tetracyclic MAPKAP-K2 (MK2) inhibitors. Part II.
Bioorganic & medicinal chemistry letters 2010;20(15):4719-23.
2010: Juraj Velcicky; Roland Feifel; Stuart Hawtin; Richard Heng; Christine Huppertz; Guido Koch; Markus Kroemer; Henrik Moebitz; Laszlo Revesz; Clemens Scheufler; Achim Schlapbach
Novel 3-aminopyrazole inhibitors of MK-2 discovered by scaffold hopping strategy.
Bioorganic & medicinal chemistry letters 2010;20(3):1293-7.
2008: Achim Schlapbach; Roland Feifel; Stuart Hawtin; Richard Heng; Guido Koch; Henrik Moebitz; Laszlo Revesz; Clemens Scheufler; Juraj Velcicky; Rudolf Waelchli; Christine Huppertz
Pyrrolo-pyrimidones: a novel class of MK2 inhibitors with potent cellular activity.
Bioorganic & medicinal chemistry letters 2008;18(23):6142-6.
2007: Volha Ninichuk; Andrej Khandoga; Stephan Segerer; Pius Loetscher; Achim Schlapbach; Laszlo Revesz; Roland Feifel; Andrej Khandoga; Fritz Krombach; Peter J Nelson; Detlef Schlöndorff; Hans-Joachim Anders
The role of interstitial macrophages in nephropathy of type 2 diabetic db/db mice.
The American journal of pathology 2007;170(4):1267-76.
2006: Philipp Janser; Ulf Neumann; Wolfgang Miltz; Roland Feifel; Thomas Buhl
A cassette-dosing approach for improvement of oral bioavailability of dual TACE/MMP inhibitors.
Bioorganic & medicinal chemistry letters 2006;16(10):2632-6.
2006: Laszlo Revesz; Ernst Blum; Franco E Di Padova; Thomas Buhl; Roland Feifel; Hermann Gram; Peter Hiestand; Ute Manning; Ulf Neumann; Gerard Rucklin
Pyrazoloheteroaryls: novel p38alpha MAP kinase inhibiting scaffolds with oral activity.
Bioorganic & medicinal chemistry letters 2006;16(2):262-6.
2006: Rudolf Waelchli; Birgit Bollbuck; Christian Bruns; Thomas Buhl; Jörg Eder; Roland Feifel; Rene Hersperger; Philipp Janser; Laszlo Revesz; Hans-Günter Zerwes; Achim Schlapbach
Design and preparation of 2-benzamido-pyrimidines as inhibitors of IKK.
Bioorganic & medicinal chemistry letters 2006;16(1):108-12.
2005: Laszlo Revesz; Birgit Bollbuck; Thomas Buhl; Jörg Eder; Ronald Esser; Roland Feifel; Richard Heng; Peter Hiestand; Benedicte Jachez-Demange; Pius Loetscher; Helmut Sparrer; Achim Schlapbach; Rudolf Waelchli
Novel CCR1 antagonists with oral activity in the mouse collagen induced arthritis.
Bioorganic & medicinal chemistry letters 2005;15(23):5160-4.
2004: Laszlo Revesz; Ernst Blum; Franco E Di Padova; Thomas Buhl; Roland Feifel; Hermann Gram; Peter Hiestand; Ute Manning; Gerard Rucklin
SAR of benzoylpyridines and benzophenones as p38alpha MAP kinase inhibitors with oral activity.
Bioorganic & medicinal chemistry letters 2004;14(13):3601-5.
2004: Laszlo Revesz; Ernst Blum; Franco E Di Padova; Thomas Buhl; Roland Feifel; Hermann Gram; Peter Hiestand; Ute Manning; Gerard Rucklin
Novel p38 inhibitors with potent oral efficacy in several models of rheumatoid arthritis.
Bioorganic & medicinal chemistry letters 2004;14(13):3595-9.
2002: Laszlo Revesz; Franco E Di Padova; Thomas Buhl; Roland Feifel; Hermann Gram; Peter Hiestand; Ute Manning; Romain Wolf; Alfred G Zimmerlin
SAR of 2,6-diamino-3,5-difluoropyridinyl substituted heterocycles as novel p38MAP kinase inhibitors.
Bioorganic & medicinal chemistry letters 2002;12(16):2109-12.
2000: Laszlo Revesz; Franco E Di Padova; Thomas Buhl; Roland Feifel; Hermann Gram; Peter Hiestand; Ute Manning; Alfred G Zimmerlin
SAR of 4-hydroxypiperidine and hydroxyalkyl substituted heterocycles as novel p38 map kinase inhibitors.
Bioorganic & medicinal chemistry letters 2000;10(11):1261-4.
1997: Gerald Künstle; Marcel Leist; S Uhlig; Laszlo Revesz; Roland Feifel; A MacKenzie; Albrecht Wendel
ICE-protease inhibitors block murine liver injury and apoptosis caused by CD95 or by TNF-alpha.
Immunology letters 1997;55(1):5-10.