Marc Feldmann

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Lymphocyte Activation

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Publications

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Hillyer Philippa; Larché Maggie J; Bowman Edward P; McClanahan Terrill K; de Waal Malefyt Rene; Schewitz Lauren P; Giddins Grey; Feldmann Marc; Kastelein Robert A; Brennan Fionula M
Investigating the role of the interleukin-23/-17A axis in rheumatoid arthritis.
Taylor Peter C; Feldmann Marc
Anti-TNF biologic agents: still the therapy of choice for rheumatoid arthritis.
Gasparini Chiara; Foxwell Brian M J; Feldmann Marc
RelB/p50 regulates CCL19 production, but fails to promote human DC maturation.

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All Publications

2009: Hillyer Philippa; Larché Maggie J; Bowman Edward P; McClanahan Terrill K; de Waal Malefyt Rene; Schewitz Lauren P; Giddins Grey; Feldmann Marc; Kastelein Robert A; Brennan Fionula M
Investigating the role of the interleukin-23/-17A axis in rheumatoid arthritis.
Rheumatology (Oxford, England) 2009;48(12):1581-9.
2009: Taylor Peter C; Feldmann Marc
Anti-TNF biologic agents: still the therapy of choice for rheumatoid arthritis.
Nature reviews. Rheumatology 2009;5(10):578-82.
2009: Gasparini Chiara; Foxwell Brian M J; Feldmann Marc
RelB/p50 regulates CCL19 production, but fails to promote human DC maturation.
European journal of immunology 2009;39(8):2215-23.
2009: Sumariwalla P F; Palmer C D; Pickford L B; Feldmann M; Foxwell B M J; Brennan F M
Suppression of tumour necrosis factor production from mononuclear cells by a novel synthetic compound, CLX-090717.
Rheumatology (Oxford, England) 2009;48(1):32-8.
2009: Brennan Fionula; Feldmann Marc
In memoriam: Professor Brian Maurice John Foxwell, 1956 to 2008.
Arthritis research & therapy 2009;11(1):104.
2009: Feldmann Marc
Translating molecular insights in autoimmunity into effective therapy.
Annual review of immunology 2009;27():1-27.
2008: Sacre Sandra M; Lo Alexandra; Gregory Bernard; Simmonds Rachel E; Williams Lynn; Feldmann Marc; Brennan Fionula M; Foxwell Brian M
Inhibitors of TLR8 reduce TNF production from human rheumatoid synovial membrane cultures.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(11):8002-9.
2008: Feldmann Marc
Many cytokines are very useful therapeutic targets in disease.
The Journal of clinical investigation 2008;118(11):3533-6.
2008: Sumariwalla Percy F; Jin Pei; Zhang Juan; Ni Irene; Crawford Damian; Shepard H Michael; Paleolog Ewa M; Feldmann Marc
Antagonism of the human epidermal growth factor receptor family controls disease severity in murine collagen-induced arthritis.
Arthritis and rheumatism 2008;58(10):3071-80.
2008: Inglis Julia J; McNamee Kay E; Chia Shi-Lu; Essex David; Feldmann Marc; Williams Richard O; Hunt Stephen P; Vincent Tonia
Regulation of pain sensitivity in experimental osteoarthritis by the endogenous peripheral opioid system.
Arthritis and rheumatism 2008;58(10):3110-9.
2008: Andersson A K; Feldmann M; Brennan F M
Neutralizing IL-21 and IL-15 inhibits pro-inflammatory cytokine production in rheumatoid arthritis.
Scandinavian journal of immunology 2008;68(1):103-11.
2008: Feldmann Marc; Maini Sir Ravinder N
Role of cytokines in rheumatoid arthritis: an education in pathophysiology and therapeutics.
Immunological reviews 2008;223():7-19.
2008: Williams Lynn M; Lali Ferdinand; Willetts Kate; Balague Cristina; Godessart Nuria; Brennan Fionula; Feldmann Marc; Foxwell Brian M J
Rac mediates TNF-induced cytokine production via modulation of NF-kappaB.
Molecular immunology 2008;45(9):2446-54.
2008: Simelyte Egle; Criado Gabriel; Essex David; Uger Robert A; Feldmann Marc; Williams Richard O
CD200-Fc, a novel antiarthritic biologic agent that targets proinflammatory cytokine expression in the joints of mice with collagen-induced arthritis.
Arthritis and rheumatism 2008;58(4):1038-43.
2008: Elliot Michael J; Maini Ravinder N; Feldmann Marc; Long-Fox Alice; Charles Peter; Katasikis Peter; Brennan Fionula M; Bijl Hanny; Ghrayeb John; Woody James N
Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to tumor necrosis factor alpha.
Arthritis and rheumatism 2008;58(2 Suppl):S92-S101.
2008: Jin Pei; Zhang Juan; Sumariwalla Percy F; Ni Irene; Jorgensen Brett; Crawford Damian; Phillips Suzanne; Feldmann Marc; Shepard H Michael; Paleolog Ewa M
Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis.
Arthritis research & therapy 2008;10(4):R73.
2008: Brennan Fionula M; Smith Nicola M G; Owen Sally; Li Ching; Amjadi Parisa; Green Patricia; Andersson Anna; Palfreeman Andrew C; Hillyer Philippa; Foey Andrew; Beech Jonathan T; Feldmann Marc
Resting CD4+ effector memory T cells are precursors of bystander-activated effectors: a surrogate model of rheumatoid arthritis synovial T-cell function.
Arthritis research & therapy 2008;10(2):R36.
2007: Inglis Julia J; Notley Clare A; Essex David; Wilson Alex W; Feldmann Marc; Anand Praveen; Williams Richard
Collagen-induced arthritis as a model of hyperalgesia: functional and cellular analysis of the analgesic actions of tumor necrosis factor blockade.
Arthritis and rheumatism 2007;56(12):4015-23.
2007: Wales J; Andreakos E; Feldmann M; Foxwell B
Targeting intracellular mediators of pattern-recognition receptor signalling to adjuvant vaccination.
Biochemical Society transactions 2007;35(Pt 6):1501-3.
2007: Sacre Sandra M; Drexler Stefan K; Andreakos Evangelos; Feldmann Marc; Brennan Fionula M; Foxwell Brian M J
Could toll-like receptors provide a missing link in chronic inflammation in rheumatoid arthritis? Lessons from a study on human rheumatoid tissue.
Annals of the rheumatic diseases 2007;66 Suppl 3():iii81-6.
2007: Lundberg Anna M; Drexler Stefan K; Monaco Claudia; Williams Lynn M; Sacre Sandra M; Feldmann Marc; Foxwell Brian M
Key differences in TLR3/poly I:C signaling and cytokine induction by human primary cells: a phenomenon absent from murine cell systems.
Blood 2007;110(9):3245-52.
2007: Inglis J J; Criado G; Andrews M; Feldmann M; Williams R O; Selley M L
The anti-allergic drug, N-(3',4'-dimethoxycinnamonyl) anthranilic acid, exhibits potent anti-inflammatory and analgesic properties in arthritis.
Rheumatology (Oxford, England) 2007;46(9):1428-32.
2007: Williams Richard O; Paleolog Ewa; Feldmann Marc
Cytokine inhibitors in rheumatoid arthritis and other autoimmune diseases.
Current opinion in pharmacology 2007;7(4):412-7.
2007: Sheryanna Abdulmunem; Bhangal Gurjeet; McDaid John; Smith Jennifer; Manning Anthony; Foxwell Brian M J; Feldmann Marc; Cook H Terence; Pusey Charles D; Tam Frederick W K
Inhibition of p38 mitogen-activated protein kinase is effective in the treatment of experimental crescentic glomerulonephritis and suppresses monocyte chemoattractant protein-1 but not IL-1beta or IL-6.
Journal of the American Society of Nephrology : JASN 2007;18(4):1167-79.
2007: Sacre Sandra M; Lundberg Anna M C; Andreakos Evangelos; Taylor Corinne; Feldmann Marc; Foxwell Brian M
Selective use of TRAM in lipopolysaccharide (LPS) and lipoteichoic acid (LTA) induced NF-kappaB activation and cytokine production in primary human cells: TRAM is an adaptor for LPS and LTA signaling.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(4):2148-54.
2007: Sacre Sandra M; Andreakos Evangelos; Kiriakidis Serafim; Amjadi Parisa; Lundberg Anna; Giddins Grey; Feldmann Marc; Brennan Fionula; Foxwell Brian M
The Toll-like receptor adaptor proteins MyD88 and Mal/TIRAP contribute to the inflammatory and destructive processes in a human model of rheumatoid arthritis.
The American journal of pathology 2007;170(2):518-25.
2007: Edwards Christopher J; Feldman Jeffrey L; Beech Jonathan; Shields Kathleen M; Stover Jennifer A; Trepicchio William L; Larsen Glenn; Foxwell Brian Mj; Brennan Fionula M; Feldmann Marc; Pittman Debra D
Molecular profile of peripheral blood mononuclear cells from patients with rheumatoid arthritis.
Molecular medicine (Cambridge, Mass.) 2007;13(1-2):40-58.
2007: Inglis Julia J; Criado Gabriel; Medghalchi Mino; Andrews Melanie; Sandison Ann; Feldmann Marc; Williams Richard O
Collagen-induced arthritis in C57BL/6 mice is associated with a robust and sustained T-cell response to type II collagen.
Arthritis research & therapy 2007;9(5):R113.
2006: Andreakos E; Williams R O; Wales J; Foxwell B M; Feldmann M
Activation of NF-kappaB by the intracellular expression of NF-kappaB-inducing kinase acts as a powerful vaccine adjuvant.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(39):14459-64.
2006: Feldmann Marc; Pusey Charles D
Is there a role for TNF-alpha in anti-neutrophil cytoplasmic antibody-associated vasculitis? Lessons from other chronic inflammatory diseases.
Journal of the American Society of Nephrology : JASN 2006;17(5):1243-52.
2006: Grosjean Jennifer; Kiriakidis Serafim; Reilly Kerri; Feldmann Marc; Paleolog Ewa
Vascular endothelial growth factor signalling in endothelial cell survival: a role for NFkappaB.
Biochemical and biophysical research communications 2006;340(3):984-94.
2006: Brennan F M; Foey A D; Feldmann M
The importance of T cell interactions with macrophages in rheumatoid cytokine production.
Current topics in microbiology and immunology 2006;305():177-94.
2005: Sacre Sandra M; Andreakos Evangelos; Taylor Peter; Feldmann Marc; Foxwell Brian M
Molecular therapeutic targets in rheumatoid arthritis.
Expert reviews in molecular medicine 2005;7(16):1-20.
2005: Feldmann Marc; Steinman Lawrence
Design of effective immunotherapy for human autoimmunity.
Nature 2005;435(7042):612-9.
2005: Feldmann Marc; Brennan Fionula M; Foxwell Brian M J; Taylor Peter C; Williams Richard O; Maini R N
Anti-TNF therapy: where have we got to in 2005?
Journal of autoimmunity 2005;25 Suppl():26-8.
2005: Andreakos Evangelos; Sacre Sandra; Foxwell Brian M; Feldmann Marc
The toll-like receptor-nuclear factor kappaB pathway in rheumatoid arthritis.
Frontiers in bioscience : a journal and virtual library 2005;10():2478-88.
2004: Taylor Peter C; Williams Richard O; Feldmann Marc
Tumour necrosis factor alpha as a therapeutic target for immune-mediated inflammatory diseases.
Current opinion in biotechnology 2004;15(6):557-63.
2004: Campbell Jamie; Ciesielski Cathleen J; Hunt Abigail E; Horwood Nicole J; Beech Jonathan T; Hayes Louise A; Denys Agnes; Feldmann Marc; Brennan Fionula M; Foxwell Brian M J
A novel mechanism for TNF-alpha regulation by p38 MAPK: involvement of NF-kappa B with implications for therapy in rheumatoid arthritis.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(11):6928-37.
2004: Andreakos Evangelos; Foxwell Brian; Feldmann Marc
Is targeting Toll-like receptors and their signaling pathway a useful therapeutic approach to modulating cytokine-driven inflammation?
Immunological reviews 2004;202():250-65.
2004: Cope Andrew P; Feldmann Marc
Emerging approaches for the therapy of autoimmune and chronic inflammatory disease.
Current opinion in immunology 2004;16(6):780-6.
2004: Pertynska-Marczewska Magdalena; Kiriakidis Serafim; Wait Robin; Beech Jonathan; Feldmann Marc; Paleolog Ewa M
Advanced glycation end products upregulate angiogenic and pro-inflammatory cytokine production in human monocyte/macrophages.
Cytokine 2004;28(1):35-47.
2004: Monaco Claudia; Andreakos Evangelos; Kiriakidis Serafim; Mauri Claudia; Bicknell Colin; Foxwell Brian; Cheshire Nicholas; Paleolog Ewa; Feldmann Marc
Canonical pathway of nuclear factor kappa B activation selectively regulates proinflammatory and prothrombotic responses in human atherosclerosis.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(15):5634-9.
2004: Sumariwalla P F; Malfait A M; Feldmann M
P-selectin glycoprotein ligand 1 therapy ameliorates established collagen-induced arthritis in DBA/1 mice partly through the suppression of tumour necrosis factor.
Clinical and experimental immunology 2004;136(1):67-75.
2004: Zhang Yuhua; Xu Jun; Levin Jeremy; Hegen Martin; Li Guangde; Robertshaw Heidi; Brennan Fionula; Cummons Terri; Clarke Dave; Vansell Nichole; Nickerson-Nutter Cheryl; Barone Dauphine; Mohler Ken; Black Roy; Skotnicki Jerry; Gibbons Jay; Feldmann Marc; Frost Philip; Larsen Glenn; Lin Lih-Ling
Identification and characterization of 4-[[4-(2-butynyloxy)phenyl]sulfonyl]-N-hydroxy-2,2-dimethyl-(3S)thiomorpholinecarboxamide (TMI-1), a novel dual tumor necrosis factor-alpha-converting enzyme/matrix metalloprotease inhibitor for the treatment of rheumatoid arthritis.
The Journal of pharmacology and experimental therapeutics 2004;309(1):348-55.
2004: Monaco Claudia; Andreakos Evangelos; Kiriakidis Serafim; Feldmann Marc; Paleolog Ewa
T-cell-mediated signalling in immune, inflammatory and angiogenic processes: the cascade of events leading to inflammatory diseases.
Current drug targets. Inflammation and allergy 2004;3(1):35-42.
2004: Sumariwalla Percy F; Gallily Ruth; Tchilibon Susanna; Fride Ester; Mechoulam Raphael; Feldmann Marc
A novel synthetic, nonpsychoactive cannabinoid acid (HU-320) with antiinflammatory properties in murine collagen-induced arthritis.
Arthritis and rheumatism 2004;50(3):985-98.
2004: Andreakos Evangelos; Sacre Sandra M; Smith Clive; Lundberg Anna; Kiriakidis Serafim; Stonehouse Tim; Monaco Claudia; Feldmann Marc; Foxwell Brian M
Distinct pathways of LPS-induced NF-kappa B activation and cytokine production in human myeloid and nonmyeloid cells defined by selective utilization of MyD88 and Mal/TIRAP.
Blood 2004;103(6):2229-37.
2004: Feldmann Marc; Brennan Fionula M; Williams Richard O; Woody James N; Maini Ravinder N
The transfer of a laboratory based hypothesis to a clinically useful therapy: the development of anti-TNF therapy of rheumatoid arthritis.
Best practice & research. Clinical rheumatology 2004;18(1):59-80.
2004: Sacre Sandra M; Andreakos Evangelos; Feldmann Mark; Foxwell Brian M
Endotoxin signaling in human macrophages: signaling via an alternate mechanism.
Journal of endotoxin research 2004;10(6):445-52.
2004: Feldmann Marc; Brennan Fionula M; Paleolog Ewa; Cope Andrew; Taylor Peter; Williams Richard; Woody Jim; Maini Ravinder N
Anti-TNFalpha therapy of rheumatoid arthritis: what can we learn about chronic disease?
Novartis Foundation symposium 2004;256():53-69; discussion 69-73, 106-11, 266-9.
2003: Foxwell B; Andreakos E; Brennan F; Feldmann M; Smith C; Conron M
Prospects for the development of small molecular weight compounds to replace anti-tumour necrosis factor biological agents.
Annals of the rheumatic diseases 2003;62 Suppl 2():ii90-3.
2003: Afuwape A O; Feldmann M; Paleolog E M
Adenoviral delivery of soluble VEGF receptor 1 (sFlt-1) abrogates disease activity in murine collagen-induced arthritis.
Gene therapy 2003;10(23):1950-60.
2003: Feldmann Marc; Maini Ravinder N
Lasker Clinical Medical Research Award. TNF defined as a therapeutic target for rheumatoid arthritis and other autoimmune diseases.
Nature medicine 2003;9(10):1245-50.
2003: Yoshimura S; Bondeson J; Brennan F M; Foxwell B M J; Feldmann M
Antigen presentation by murine dendritic cells is nuclear factor-kappa B dependent both in vitro and in vivo.
Scandinavian journal of immunology 2003;58(2):165-72.
2003: Andreakos Evangelos; Smith Clive; Kiriakidis Serafim; Monaco Claudia; de Martin Rainer; Brennan Fionula M; Paleolog Ewa; Feldmann Marc; Foxwell Brian M
Heterogeneous requirement of IkappaB kinase 2 for inflammatory cytokine and matrix metalloproteinase production in rheumatoid arthritis: implications for therapy.
Arthritis and rheumatism 2003;48(7):1901-12.
2003: Calder V L; Bondeson J; Brennan F M; Foxwell B M J; Feldmann M
Antigen-specific T-cell downregulation by human dendritic cells following blockade of NF-kappaB.
Scandinavian journal of immunology 2003;57(3):261-70.
2003: Kiriakidis Serafim; Andreakos Evangelos; Monaco Claudia; Foxwell Brian; Feldmann Marc; Paleolog Ewa
VEGF expression in human macrophages is NF-kappaB-dependent: studies using adenoviruses expressing the endogenous NF-kappaB inhibitor IkappaBalpha and a kinase-defective form of the IkappaB kinase 2.
Journal of cell science 2003;116(Pt 4):665-74.
2003: Andreakos Evangelos; Smith Clive; Monaco Claudia; Brennan Fionula M; Foxwell Brian M; Feldmann Marc
Ikappa B kinase 2 but not NF-kappa B-inducing kinase is essential for effective DC antigen presentation in the allogeneic mixed lymphocyte reaction.
Blood 2003;101(3):983-91.
2003: Foey Andrew D; Field Sarah; Ahmed Salman; Jain Abhilash; Feldmann Marc; Brennan Fionula M; Williams Richard
Impact of VIP and cAMP on the regulation of TNF-alpha and IL-10 production: implications for rheumatoid arthritis.
Arthritis research & therapy 2003;5(6):R317-28.
2003: Sumariwalla Percy F; Cao Yihai; Wu Hua-Lin; Feldmann Marc; Paleolog Ewa M
The angiogenesis inhibitor protease-activated kringles 1-5 reduces the severity of murine collagen-induced arthritis.
Arthritis research & therapy 2003;5(1):R32-9.
2002: Andreakos Evangelos; Taylor Peter C; Feldmann Marc
Monoclonal antibodies in immune and inflammatory diseases.
Current opinion in biotechnology 2002;13(6):615-20.
2002: Feldmann M; Andreakos E; Smith C; Bondeson J; Yoshimura S; Kiriakidis S; Monaco C; Gasparini C; Sacre S; Lundberg A; Paleolog E; Horwood N J; Brennan F M; Foxwell B M J
Is NF-kappaB a useful therapeutic target in rheumatoid arthritis?
Annals of the rheumatic diseases 2002;61 Suppl 2():ii13-8.
2002: Andreakos Evangelos T; Foxwell Brian M; Brennan Fionula M; Maini Ravinder N; Feldmann Marc
Cytokines and anti-cytokine biologicals in autoimmunity: present and future.
Cytokine & growth factor reviews 2002;13(4-5):299-313.
2002: Ciesielski Cathleen J; Andreakos Evangelos; Foxwell Brian M J; Feldmann Marc
TNFalpha-induced macrophage chemokine secretion is more dependent on NF-kappaB expression than lipopolysaccharides-induced macrophage chemokine secretion.
European journal of immunology 2002;32(7):2037-45.
2002: Feldmann Marc
Development of anti-TNF therapy for rheumatoid arthritis.
Nature reviews. Immunology 2002;2(5):364-71.
2002: Monaco Claudia; Andreakos Evangelos; Young Sylvia; Feldmann Marc; Paleolog Ewa
T cell-mediated signaling to vascular endothelium: induction of cytokines, chemokines, and tissue factor.
Journal of leukocyte biology 2002;71(4):659-68.
2002: Feldmann Marc; Maini Ravinder N
Discovery of TNF-alpha as a therapeutic target in rheumatoid arthritis: preclinical and clinical studies.
Joint, bone, spine : revue du rhumatisme 2002;69(1):12-8.
2002: Brennan Fionula M; Hayes Amanda L; Ciesielski Cathleen J; Green Patricia; Foxwell Brian M J; Feldmann Marc
Evidence that rheumatoid arthritis synovial T cells are similar to cytokine-activated T cells: involvement of phosphatidylinositol 3-kinase and nuclear factor kappaB pathways in tumor necrosis factor alpha production in rheumatoid arthritis.
Arthritis and rheumatism 2002;46(1):31-41.
2002: Maini Ravinder N; Feldmann Marc
How does infliximab work in rheumatoid arthritis?
Arthritis research 2002;4 Suppl 2():S22-8.
2002: Horwood Nicole J; Smith Clive; Andreakos Evangelos; Quattrocchi Emilia; Brennan Fionula M; Feldmann Marc; Foxwell Brian M J
High-efficiency gene transfer into nontransformed cells: utility for studying gene regulation and analysis of potential therapeutic targets.
Arthritis research 2002;4 Suppl 3():S215-25.
2002: Foey Andrew; Green Patricia; Foxwell Brian; Feldmann Marc; Brennan Fionula
Cytokine-stimulated T cells induce macrophage IL-10 production dependent on phosphatidylinositol 3-kinase and p70S6K: implications for rheumatoid arthritis.
Arthritis research 2002;4(1):64-70.
2001: Foxwell B M; Yoshimura S; Bondeson J; Brennan F M; Feldmann M
High efficiency gene transfer is an efficient way of defining therapeutic targets: a functional genomics approach.
Annals of the rheumatic diseases 2001;60 Suppl 3():iii13-7.
2001: Foey A D; Feldmann M; Brennan F M
CD40 ligation induces macrophage IL-10 and TNF-alpha production: differential use of the PI3K and p42/44 MAPK-pathways.
Cytokine 2001;16(4):131-42.
2001: Smith C; Andreakos E; Crawley J B; Brennan F M; Feldmann M; Foxwell B M
NF-kappaB-inducing kinase is dispensable for activation of NF-kappaB in inflammatory settings but essential for lymphotoxin beta receptor activation of NF-kappaB in primary human fibroblasts.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(10):5895-903.
2001: Ballara S; Taylor P C; Reusch P; Marmé D; Feldmann M; Maini R N; Paleolog E M
Raised serum vascular endothelial growth factor levels are associated with destructive change in inflammatory arthritis.
Arthritis and rheumatism 2001;44(9):2055-64.
2001: Conron M; Bondeson J; Pantelidis P; Beynon H L; Feldmann M; duBois R M; Foxwell B M
Alveolar macrophages and T cells from sarcoid, but not normal lung, are permissive to adenovirus infection and allow analysis of NF-kappa b-dependent signaling pathways.
American journal of respiratory cell and molecular biology 2001;25(2):141-9.
2001: Yoshimura S; Bondeson J; Brennan F M; Foxwell B M; Feldmann M
Role of NFkappaB in antigen presentation and development of regulatory T cells elucidated by treatment of dendritic cells with the proteasome inhibitor PSI.
European journal of immunology 2001;31(6):1883-93.
2001: Feldmann M; Brennan F; Bondeson J; Paleolog E; Foxwell B; Maini R
Analysis of cytokine expression in rheumatoid synovium has provided new insights into the pathogenesis of rheumatoid arthritis and new therapeutic opportunities.
Transplantation proceedings 2001;33(3):2085-6.
2001: Malfait A M; Williams R O; Malik A S; Maini R N; Feldmann M
Chronic relapsing homologous collagen-induced arthritis in DBA/1 mice as a model for testing disease-modifying and remission-inducing therapies.
Arthritis and rheumatism 2001;44(5):1215-24.
2001: Quattrocchi E; Dallman M J; Dhillon A P; Quaglia A; Bagnato G; Feldmann M
Murine IL-10 gene transfer inhibits established collagen-induced arthritis and reduces adenovirus-mediated inflammatory responses in mouse liver.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(10):5970-8.
2001: Yoshimura S; Bondeson J; Foxwell B M; Brennan F M; Feldmann M
Effective antigen presentation by dendritic cells is NF-kappaB dependent: coordinate regulation of MHC, co-stimulatory molecules and cytokines.
International immunology 2001;13(5):675-83.
2001: Gabay C; Marinova-Mutafchieva L; Williams R O; Gigley J P; Butler D M; Feldmann M; Arend W P
Increased production of intracellular interleukin-1 receptor antagonist type I in the synovium of mice with collagen-induced arthritis: a possible role in the resolution of arthritis.
Arthritis and rheumatism 2001;44(2):451-62.
2001: Feldmann M; Maini R N; Bondeson J; Taylor P; Foxwell B M; Brennan F M
Cytokine blockade in rheumatoid arthritis.
Advances in experimental medicine and biology 2001;490():119-27.
2001: Feldmann M; Maini R N
Anti-TNF alpha therapy of rheumatoid arthritis: what have we learned?
Annual review of immunology 2001;19():163-96.
2000: Williams R O; Marinova-Mutafchieva L; Feldmann M; Maini R N
Evaluation of TNF-alpha and IL-1 blockade in collagen-induced arthritis and comparison with combined anti-TNF-alpha/anti-CD4 therapy.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(12):7240-5.
2000: Charles P J; Smeenk R J; De Jong J; Feldmann M; Maini R N
Assessment of antibodies to double-stranded DNA induced in rheumatoid arthritis patients following treatment with infliximab, a monoclonal antibody to tumor necrosis factor alpha: findings in open-label and randomized placebo-controlled trials.
Arthritis and rheumatism 2000;43(11):2383-90.
2000: Feldmann M; Miotla J; Paleolog E; Williams R; Malfait A M; Taylor P; Brennan F M; Maini R N
Future prospects for anti-cytokine treatment.
Annals of the rheumatic diseases 2000;59 Suppl 1():i119-22.
2000: Williams R O; Feldmann M; Maini R N
Cartilage destruction and bone erosion in arthritis: the role of tumour necrosis factor alpha.
Annals of the rheumatic diseases 2000;59 Suppl 1():i75-80.
2000: Foxwell B M; Bondeson J; Brennan F; Feldmann M
Adenoviral transgene delivery provides an approach to identifying important molecular processes in inflammation: evidence for heterogenecity in the requirement for NFkappaB in tumour necrosis factor production.
Annals of the rheumatic diseases 2000;59 Suppl 1():i54-9.
2000: Foey A D; Feldmann M; Brennan F M
Route of monocyte differentiation determines their cytokine production profile: CD40 ligation induces interleukin 10 expression.
Cytokine 2000;12(10):1496-505.
2000: Bondeson J; Brennan F; Foxwell B; Feldmann M
Effective adenoviral transfer of IkappaBalpha into human fibroblasts and chondrosarcoma cells reveals that the induction of matrix metalloproteinases and proinflammatory cytokines is nuclear factor-kappaB dependent.
The Journal of rheumatology 2000;27(9):2078-89.
2000: Miotla J; Maciewicz R; Kendrew J; Feldmann M; Paleolog E
Treatment with soluble VEGF receptor reduces disease severity in murine collagen-induced arthritis.
Laboratory investigation; a journal of technical methods and pathology 2000;80(8):1195-205.
2000: Quattrocchi E; Dallman M J; Feldmann M
Adenovirus-mediated gene transfer of CTLA-4Ig fusion protein in the suppression of experimental autoimmune arthritis.
Arthritis and rheumatism 2000;43(8):1688-97.
2000: Malfait A M; Gallily R; Sumariwalla P F; Malik A S; Andreakos E; Mechoulam R; Feldmann M
The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(17):9561-6.
2000: Marinova-Mutafchieva L; Williams R O; Mauri C; Mason L J; Walmsley M J; Taylor P C; Feldmann M; Maini R N
A comparative study into the mechanisms of action of anti-tumor necrosis factor alpha, anti-CD4, and combined anti-tumor necrosis factor alpha/anti-CD4 treatment in early collagen-induced arthritis.
Arthritis and rheumatism 2000;43(3):638-44.
2000: Taylor P C; Peters A M; Paleolog E; Chapman P T; Elliott M J; McCloskey R; Feldmann M; Maini R N
Reduction of chemokine levels and leukocyte traffic to joints by tumor necrosis factor alpha blockade in patients with rheumatoid arthritis.
Arthritis and rheumatism 2000;43(1):38-47.
1999: Feldmann M; Maini R N
The role of cytokines in the pathogenesis of rheumatoid arthritis.
Rheumatology (Oxford, England) 1999;38 Suppl 2():3-7.
1999: Williams R O; Malfait A M; Butler D M; Walmsley M J; Feldmann M; Maini R N
Combination therapy with DMARDs and biological agents in collagen-induced arthritis.
Clinical and experimental rheumatology 1999;17(6 Suppl 18):S115-20.
1999: Webb L M; Foxwell B M; Feldmann M
Putative role for interleukin-7 in the maintenance of the recirculating naive CD4+ T-cell pool.
Immunology 1999;98(3):400-5.
1999: Maini R N; Taylor P C; Paleolog E; Charles P; Ballara S; Brennan F M; Feldmann M
Anti-tumour necrosis factor specific antibody (infliximab) treatment provides insights into the pathophysiology of rheumatoid arthritis.
Annals of the rheumatic diseases 1999;58 Suppl 1():I56-60.
1999: Feldmann M; Bondeson J; Brennan F M; Foxwell B M; Maini R N
The rationale for the current boom in anti-TNFalpha treatment. Is there an effective means to define therapeutic targets for drugs that provide all the benefits of anti-TNFalpha and minimise hazards?
Annals of the rheumatic diseases 1999;58 Suppl 1():I27-31.
1999: Charles P; Elliott M J; Davis D; Potter A; Kalden J R; Antoni C; Breedveld F C; Smolen J S; Eberl G; deWoody K; Feldmann M; Maini R N
Regulation of cytokines, cytokine inhibitors, and acute-phase proteins following anti-TNF-alpha therapy in rheumatoid arthritis.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(3):1521-8.
1999: Butler D M; Malfait A M; Maini R N; Brennan F M; Feldmann M
Anti-IL-12 and anti-TNF antibodies synergistically suppress the progression of murine collagen-induced arthritis.
European journal of immunology 1999;29(7):2205-12.
1999: Quattrocchi E; Walmsley M; Browne K; Williams R O; Marinova-Mutafchieva L; Buurman W; Butler D M; Feldmann M
Paradoxical effects of adenovirus-mediated blockade of TNF activity in murine collagen-induced arthritis.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(2):1000-9.
1999: Bondeson J; Foxwell B; Brennan F; Feldmann M
Defining therapeutic targets by using adenovirus: blocking NF-kappaB inhibits both inflammatory and destructive mechanisms in rheumatoid synovium but spares anti-inflammatory mediators.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(10):5668-73.
1999: Malfait A M; Malik A S; Marinova-Mutafchieva L; Butler D M; Maini R N; Feldmann M
The beta2-adrenergic agonist salbutamol is a potent suppressor of established collagen-induced arthritis: mechanisms of action.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(10):6278-83.
1999: Bondeson J; Browne K A; Brennan F M; Foxwell B M; Feldmann M
Selective regulation of cytokine induction by adenoviral gene transfer of IkappaBalpha into human macrophages: lipopolysaccharide-induced, but not zymosan-induced, proinflammatory cytokines are inhibited, but IL-10 is nuclear factor-kappaB independent.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(5):2939-45.
1998: Williams R O; Mauri C; Mason L J; Marinova-Mutafchieva L; Ross S E; Feldmann M; Maini R N
Therapeutic actions of cyclosporine and anti-tumor necrosis factor alpha in collagen-induced arthritis and the effect of combination therapy.
Arthritis and rheumatism 1998;41(10):1806-12.
1998: Walmsley M; Butler D M; Marinova-Mutafchieva L; Feldmann M
An anti-inflammatory role for interleukin-11 in established murine collagen-induced arthritis.
Immunology 1998;95(1):31-7.
1998: Maini R N; Breedveld F C; Kalden J R; Smolen J S; Davis D; Macfarlane J D; Antoni C; Leeb B; Elliott M J; Woody J N; Schaible T F; Feldmann M
Therapeutic efficacy of multiple intravenous infusions of anti-tumor necrosis factor alpha monoclonal antibody combined with low-dose weekly methotrexate in rheumatoid arthritis.
Arthritis and rheumatism 1998;41(9):1552-63.
1998: Hermann J A; Hall M A; Maini R N; Feldmann M; Brennan F M
Important immunoregulatory role of interleukin-11 in the inflammatory process in rheumatoid arthritis.
Arthritis and rheumatism 1998;41(8):1388-97.
1998: Paleolog E M; Young S; Stark A C; McCloskey R V; Feldmann M; Maini R N
Modulation of angiogenic vascular endothelial growth factor by tumor necrosis factor alpha and interleukin-1 in rheumatoid arthritis.
Arthritis and rheumatism 1998;41(7):1258-65.
1998: Foxwell B; Browne K; Bondeson J; Clarke C; de Martin R; Brennan F; Feldmann M
Efficient adenoviral infection with IkappaB alpha reveals that macrophage tumor necrosis factor alpha production in rheumatoid arthritis is NF-kappaB dependent.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(14):8211-5.
1998: Sanz M J; Marinova-Mutafchieva L; Green P; Lobb R R; Feldmann M; Nourshargh S
IL-4-induced eosinophil accumulation in rat skin is dependent on endogenous TNF-alpha and alpha 4 integrin/VCAM-1 adhesion pathways.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(11):5637-45.
1998: Malfait A M; Butler D M; Presky D H; Maini R N; Brennan F M; Feldmann M
Blockade of IL-12 during the induction of collagen-induced arthritis (CIA) markedly attenuates the severity of the arthritis.
Clinical and experimental immunology 1998;111(2):377-83.
1998: Foey A D; Parry S L; Williams L M; Feldmann M; Foxwell B M; Brennan F M
Regulation of monocyte IL-10 synthesis by endogenous IL-1 and TNF-alpha: role of the p38 and p42/44 mitogen-activated protein kinases.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(2):920-8.
1998: Feldmann M; Brennan F M; Maini R
Cytokines in autoimmune disorders.
International reviews of immunology 1998;17(1-4):217-28.
1998: Feldmann M; Charles P; Taylor P; Maini R N
Biological insights from clinical trials with anti-TNF therapy.
Springer seminars in immunopathology 1998;20(1-2):211-28.
1998: Brennan F M; Maini R N; Feldmann M
Role of pro-inflammatory cytokines in rheumatoid arthritis.
Springer seminars in immunopathology 1998;20(1-2):133-47.
1998: Feldmann M; Maini R N
Rheumatoid arthritis: introduction.
Springer seminars in immunopathology 1998;20(1-2):3-4.
1997: Ross S E; Williams R O; Mason L J; Mauri C; Marinova-Mutafchieva L; Malfait A M; Maini R N; Feldmann M
Suppression of TNF-alpha expression, inhibition of Th1 activity, and amelioration of collagen-induced arthritis by rolipram.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(12):6253-9.
1997: Horsfall A C; Butler D M; Marinova L; Warden P J; Williams R O; Maini R N; Feldmann M
Suppression of collagen-induced arthritis by continuous administration of IL-4.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(11):5687-96.
1997: Sanz M J; Hartnell A; Chisholm P; Williams C; Davies D; Weg V B; Feldmann M; Bolanowski M A; Lobb R R; Nourshargh S
Tumor necrosis factor alpha-induced eosinophil accumulation in rat skin is dependent on alpha4 integrin/vascular cell adhesion molecule-1 adhesion pathways.
Blood 1997;90(10):4144-52.
1997: Davis D; Charles P J; Potter A; Feldmann M; Maini R N; Elliott M J
Anaemia of chronic disease in rheumatoid arthritis: in vivo effects of tumour necrosis factor alpha blockade.
British journal of rheumatology 1997;36(9):950-6.
1997: Cohen S B; Crawley J B; Kahan M C; Feldmann M; Foxwell B M
Interleukin-10 rescues T cells from apoptotic cell death: association with an upregulation of Bcl-2.
Immunology 1997;92(1):1-5.
1997: Feldmann M; Brennan F; Paleolog E; Taylor P; Maini R N
Anti-tumor necrosis factor alpha therapy of rheumatoid arthritis. Mechanism of action.
European cytokine network 1997;8(3):297-300.
1997: Butler D M; Malfait A M; Mason L J; Warden P J; Kollias G; Maini R N; Feldmann M; Brennan F M
DBA/1 mice expressing the human TNF-alpha transgene develop a severe, erosive arthritis: characterization of the cytokine cascade and cellular composition.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(6):2867-76.
1997: Fiehn C; Paleolog E M; Feldmann M
Selective enhancement of endothelial cell VCAM-1 expression by interleukin-10 in the presence of activated leucocytes.
Immunology 1997;91(4):565-71.
1997: Brennan F M; Browne K A; Green P A; Jaspar J M; Maini R N; Feldmann M
Reduction of serum matrix metalloproteinase 1 and matrix metalloproteinase 3 in rheumatoid arthritis patients following anti-tumour necrosis factor-alpha (cA2) therapy.
British journal of rheumatology 1997;36(6):643-50.
1997: Maini R N; Elliott M; Brennan F M; Williams R O; Feldmann M
TNF blockade in rheumatoid arthritis: implications for therapy and pathogenesis.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 1997;105(4):257-63.
1997: Parry S L; Sebbag M; Feldmann M; Brennan F M
Contact with T cells modulates monocyte IL-10 production: role of T cell membrane TNF-alpha.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(8):3673-81.
1997: Webb L M; Foxwell B M; Feldmann M
Interleukin-7 activates human naive CD4+ cells and primes for interleukin-4 production.
European journal of immunology 1997;27(3):633-40.
1997: Sebbag M; Parry S L; Brennan F M; Feldmann M
Cytokine stimulation of T lymphocytes regulates their capacity to induce monocyte production of tumor necrosis factor-alpha, but not interleukin-10: possible relevance to pathophysiology of rheumatoid arthritis.
European journal of immunology 1997;27(3):624-32.
1997: Marinova-Mutafchieva L; Williams R O; Mason L J; Mauri C; Feldmann M; Maini R N
Dynamics of proinflammatory cytokine expression in the joints of mice with collagen-induced arthritis (CIA).
Clinical and experimental immunology 1997;107(3):507-12.
1997: Feldmann M; Elliott M J; Woody J N; Maini R N
Anti-tumor necrosis factor-alpha therapy of rheumatoid arthritis.
Advances in immunology 1997;64():283-350.
1996: Webb L M; Walmsley M J; Feldmann M
Prevention and amelioration of collagen-induced arthritis by blockade of the CD28 co-stimulatory pathway: requirement for both B7-1 and B7-2.
European journal of immunology 1996;26(10):2320-8.
1996: Mauri C; Williams R O; Walmsley M; Feldmann M
Relationship between Th1/Th2 cytokine patterns and the arthritogenic response in collagen-induced arthritis.
European journal of immunology 1996;26(7):1511-8.
1996: Paleolog E M; Hunt M; Elliott M J; Feldmann M; Maini R N; Woody J N
Deactivation of vascular endothelium by monoclonal anti-tumor necrosis factor alpha antibody in rheumatoid arthritis.
Arthritis and rheumatism 1996;39(7):1082-91.
1996: Williams L M; Gibbons D L; Gearing A; Maini R N; Feldmann M; Brennan F M
Paradoxical effects of a synthetic metalloproteinase inhibitor that blocks both p55 and p75 TNF receptor shedding and TNF alpha processing in RA synovial membrane cell cultures.
The Journal of clinical investigation 1996;97(12):2833-41.
1996: Neve R; Kissonerghis M; Clark J; Feldmann M; Chernajovsky Y
Expression of an efficient small molecular weight tumour necrosis factor/lymphotoxin antagonist.
Cytokine 1996;8(5):365-70.
1996: Cohen S B; Webb L M; Feldmann M
The method of deriving human T-cell clones alters the proportion of IL-10-producing cells.
Immunology 1996;87(3):343-7.
1996: Walmsley M; Katsikis P D; Abney E; Parry S; Williams R O; Maini R N; Feldmann M
Interleukin-10 inhibition of the progression of established collagen-induced arthritis.
Arthritis and rheumatism 1996;39(3):495-503.
1996: Norman K E; Williams T J; Feldmann M; Rossi A G
Effect of soluble P55 tumour-necrosis factor binding fusion protein on the local Shwartzman and Arthus reactions.
British journal of pharmacology 1996;117(3):471-478.
1996: Quaratino S; Feldmann M; Dayan C M; Acuto O; Londei M
Human self-reactive T cell clones expressing identical T cell receptor beta chains differ in their ability to recognize a cryptic self-epitope.
The Journal of experimental medicine 1996;183(2):349-58.
1996: Brookes S M; Cohen S B; Price E J; Webb L M; Feldmann M; Maini R N; Venables P J
T cell clones from a Sjögren's syndrome salivary gland biopsy produce high levels of IL-10.
Clinical and experimental immunology 1996;103(2):268-72.
1995: Scallon B J; Trinh H; Nedelman M; Brennan F M; Feldmann M; Ghrayeb J
Functional comparisons of different tumour necrosis factor receptor/IgG fusion proteins.
Cytokine 1995;7(8):759-70.
1995: Webb L M; Feldmann M
Critical role of CD28/B7 costimulation in the development of human Th2 cytokine-producing cells.
Blood 1995;86(9):3479-86.
1995: Clarke C J; Taylor-Fishwick D A; Hales A; Chernajovsky Y; Sugamura K; Feldmann M; Foxwell B M
Interleukin-4 inhibits kappa light chain expression and NF kappa B activation but not I kappa B alpha degradation in 70Z/3 murine pre-B cells.
European journal of immunology 1995;25(10):2961-6.
1995: Feldmann M; Brennan F M; Elliott M J; Williams R O; Maini R N
TNF alpha is an effective therapeutic target for rheumatoid arthritis.
Annals of the New York Academy of Sciences 1995;766():272-8.
1995: Maini R N; Elliott M J; Brennan F M; Feldmann M
Beneficial effects of tumour necrosis factor-alpha (TNF-alpha) blockade in rheumatoid arthritis (RA)
Clinical and experimental immunology 1995;101(2):207-12.
1995: Katsikis P D; Cohen S B; Londei M; Feldmann M
Are CD4+ Th1 cells pro-inflammatory or anti-inflammatory? The ratio of IL-10 to IFN-gamma or IL-2 determines their function.
International immunology 1995;7(8):1287-94.
1995: Butler D M; Maini R N; Feldmann M; Brennan F M
Modulation of proinflammatory cytokine release in rheumatoid synovial membrane cell cultures. Comparison of monoclonal anti TNF-alpha antibody with the interleukin-1 receptor antagonist.
European cytokine network 1995;6(4):225-30.
1995: Chu N R; Quaratino S; Feldmann M; Londei M
Comparison of peptide and superantigen-induced anergy in a peptide-specific polyclonal human T cell line.
International immunology 1995;7(7):1057-63.
1995: Londei M; Dayan C; Feldmann M; Acuto O; Quaratino S
Human autoreactive T-cell clones show flexibility in recognizing overlapping microepitopes, but inflexibility in T-cell receptor usage.
Annals of the New York Academy of Sciences 1995;756():345-8.
1995: Brennan F M; Gibbons D L; Cope A P; Katsikis P; Maini R N; Feldmann M
TNF inhibitors are produced spontaneously by rheumatoid and osteoarthritic synovial joint cell cultures: evidence of feedback control of TNF action.
Scandinavian journal of immunology 1995;42(1):158-65.
1995: Mullins R J; Cohen S B; Webb L M; Chernajovsky Y; Dayan C M; Londei M; Feldmann M
Identification of thyroid stimulating hormone receptor-specific T cells in Graves' disease thyroid using autoantigen-transfected Epstein-Barr virus-transformed B cell lines.
The Journal of clinical investigation 1995;96(1):30-7.
1995: Cohen S B; Katsikis P D; Chu C Q; Thomssen H; Webb L M; Maini R N; Londei M; Feldmann M
High level of interleukin-10 production by the activated T cell population within the rheumatoid synovial membrane.
Arthritis and rheumatism 1995;38(7):946-52.
1995: Katsikis P D; Cohen S B; Murison J G; Uren J; Hibbart L M; Callard R E; Di Padova F; Feldmann M; Londei M
Human alpha beta T-cell receptor CD4-CD8 T-cell clones are predominantly Th0-like.
Immunology 1995;84(4):501-4.
1995: Maini R N; Elliott M J; Brennan F M; Williams R O; Chu C Q; Paleolog E; Charles P J; Taylor P C; Feldmann M
Monoclonal anti-TNF alpha antibody as a probe of pathogenesis and therapy of rheumatoid disease.
Immunological reviews 1995;144():195-223.
1995: Williams R O; Ghrayeb J; Feldmann M; Maini R N
Successful therapy of collagen-induced arthritis with TNF receptor-IgG fusion protein and combination with anti-CD4.
Immunology 1995;84(3):433-9.
1995: Weg V B; Walsh D T; Faccioli L H; Williams T J; Feldmann M; Nourshargh S
LPS-induced 111In-eosinophil accumulation in guinea-pig skin: evidence for a role for TNF-alpha.
Immunology 1995;84(1):36-40.
1995: Cope A P; Aderka D; Wallach D; Kahan M; Chu N R; Brennan F M; Feldmann M
Soluble TNF receptor production by activated T lymphocytes: differential effects of acute and chronic exposure to TNF.
Immunology 1995;84(1):21-30.
1995: Brennan F M; Cope A P; Katsikis P; Gibbons D L; Maini R N; Feldmann M
Selective immunosuppression of tumour necrosis factor-alpha in rheumatoid arthritis.
Chemical immunology 1995;60():48-60.
1994: Butler D M; Scallon B; Meager A; Kissonerghis M; Corcoran A; Chernajovsky Y; Feldmann M; Ghrayeb J; Brennan F M
TNF receptor fusion proteins are effective inhibitors of TNF-mediated cytotoxicity on human KYM-1D4 rhabdomyosarcoma cells.
Cytokine 1994;6(6):616-23.
1994: Cohen S B; Katsikis P D; Feldmann M; Londei M
IL-10 enhances expression of the IL-2 receptor alpha chain on T cells.
Immunology 1994;83(3):329-32.
1994: Maini R N; Elliott M; Brennan F M; Williams R O; Feldmann M
Targeting TNF alpha for the therapy of rheumatoid arthritis.
Clinical and experimental rheumatology 1994;12 Suppl 11():S63-6.
1994: Elliott M J; Maini R N; Feldmann M; Long-Fox A; Charles P; Bijl H; Woody J N
Repeated therapy with monoclonal antibody to tumour necrosis factor alpha (cA2) in patients with rheumatoid arthritis.
Lancet 1994;344(8930):1125-7.
1994: Elliott M J; Maini R N; Feldmann M; Kalden J R; Antoni C; Smolen J S; Leeb B; Breedveld F C; Macfarlane J D; Bijl H
Randomised double-blind comparison of chimeric monoclonal antibody to tumour necrosis factor alpha (cA2) versus placebo in rheumatoid arthritis.
Lancet 1994;344(8930):1105-10.
1994: Paleolog E M; Delasalle S A; Buurman W A; Feldmann M
Functional activities of receptors for tumor necrosis factor-alpha on human vascular endothelial cells.
Blood 1994;84(8):2578-90.
1994: Butler D M; Feldmann M; Di Padova F; Brennan F M
p55 and p75 tumor necrosis factor receptors are expressed and mediate common functions in synovial fibroblasts and other fibroblasts.
European cytokine network 1994;5(5):441-8.
1994: Gibbons D L; Rowe M; Cope A P; Feldmann M; Brennan F M
Lymphotoxin acts as an autocrine growth factor for Epstein-Barr virus-transformed B cells and differentiated Burkitt lymphoma cell lines.
European journal of immunology 1994;24(8):1879-85.
1994: Corcoran A E; Barrett K; Turner M; Brown A; Kissonerghis A M; Gadnell M; Gray P W; Chernajovsky Y; Feldmann M
Characterization of ligand binding by the human p55 tumour-necrosis-factor receptor. Involvement of individual cysteine-rich repeats.
European journal of biochemistry / FEBS 1994;223(3):831-40.
1994: Cope A P; Londei M; Chu N R; Cohen S B; Elliott M J; Brennan F M; Maini R N; Feldmann M
Chronic exposure to tumor necrosis factor (TNF) in vitro impairs the activation of T cells through the T cell receptor/CD3 complex; reversal in vivo by anti-TNF antibodies in patients with rheumatoid arthritis.
The Journal of clinical investigation 1994;94(2):749-60.
1994: Mullins R J; Chernajovsky Y; Dayan C; Londei M; Feldmann M
Transfection of thyroid autoantigens into EBV-transformed B cell lines. Recognition by Graves' disease thyroid T cells.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(11):5572-80.
1994: Katsikis P D; Chu C Q; Brennan F M; Maini R N; Feldmann M
Immunoregulatory role of interleukin 10 in rheumatoid arthritis.
The Journal of experimental medicine 1994;179(5):1517-27.
1994: Williams R O; Mason L J; Feldmann M; Maini R N
Synergy between anti-CD4 and anti-tumor necrosis factor in the amelioration of established collagen-induced arthritis.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(7):2762-6.
1994: Maini R N; Elliott M J; Charles P J; Feldmann M
Immunological intervention reveals reciprocal roles for tumor necrosis factor-alpha and interleukin-10 in rheumatoid arthritis and systemic lupus erythematosus.
Springer seminars in immunopathology 1994;16(2-3):327-36.
1993: Elliott M J; Maini R N; Feldmann M; Long-Fox A; Charles P; Katsikis P; Brennan F M; Walker J; Bijl H; Ghrayeb J
Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to tumor necrosis factor alpha.
Arthritis and rheumatism 1993;36(12):1681-90.
1993: Kristensen M; Chu C Q; Eedy D J; Feldmann M; Brennan F M; Breathnach S M
Localization of tumour necrosis factor-alpha (TNF-alpha) and its receptors in normal and psoriatic skin: epidermal cells express the 55-kD but not the 75-kD TNF receptor.
Clinical and experimental immunology 1993;94(2):354-62.
1993: Paleolog E M; Katsikis P; Harris G; Daddona P; Dalesandro M R; Kinney C S; Woody J N; Feldmann M
Antilipid A monoclonal antibody HA-1A decreases the capacity of bacterial lipopolysaccharide to activate human vascular endothelial cells by an immune adherence mechanism.
Cytokine 1993;5(6):570-7.
1993: Aderka D; Wysenbeek A; Engelmann H; Cope A P; Brennan F; Molad Y; Hornik V; Levo Y; Maini R N; Feldmann M
Correlation between serum levels of soluble tumor necrosis factor receptor and disease activity in systemic lupus erythematosus.
Arthritis and rheumatism 1993;36(8):1111-20.
1993: Dayan C M; Chu N R; Londei M; Rapoport B; Feldmann M
T cells involved in human autoimmune disease are resistant to tolerance induction.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(3):1606-13.
1993: Haworth C; O'Reilly S M; Chu E; Rustin G J; Feldmann M
Flavone acetic acid (FAA) with recombinant interleukin-2 (rIL-2) in advanced malignant melanoma. III: Cytokine studies.
British journal of cancer 1993;67(6):1346-50.
1993: Cope A P; Gibbons D L; Aderka D; Foxwell B M; Wallach D; Maini R N; Feldmann M; Brennan F M
Differential regulation of tumour necrosis factor receptors (TNF-R) by IL-4; upregulation of P55 and P75 TNF-R on synovial joint mononuclear cells.
Cytokine 1993;5(3):205-12.
1993: Maini R N; Brennan F M; Williams R; Chu C Q; Cope A P; Gibbons D; Elliott M; Feldmann M
TNF-alpha in rheumatoid arthritis and prospects of anti-TNF therapy.
Clinical and experimental rheumatology 1993;11 Suppl 8():S173-5.
1992: Deleuran B W; Chu C Q; Field M; Brennan F M; Katsikis P; Feldmann M; Maini R N
Localization of interleukin-1 alpha, type 1 interleukin-1 receptor and interleukin-1 receptor antagonist in the synovial membrane and cartilage/pannus junction in rheumatoid arthritis.
British journal of rheumatology 1992;31(12):801-9.
1992: Foxwell B M; Barrett K; Feldmann M
Cytokine receptors: structure and signal transduction.
Clinical and experimental immunology 1992;90(2):161-9.
1992: Paleolog E M; Aluri G R; Feldmann M
Contrasting effects of interferon gamma and interleukin 4 on responses of human vascular endothelial cells to tumour necrosis factor alpha.
Cytokine 1992;4(6):470-8.
1992: Williams R O; Feldmann M; Maini R N
Anti-tumor necrosis factor ameliorates joint disease in murine collagen-induced arthritis.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(20):9784-8.
1992: Chu C Q; Field M; Allard S; Abney E; Feldmann M; Maini R N
Detection of cytokines at the cartilage/pannus junction in patients with rheumatoid arthritis: implications for the role of cytokines in cartilage destruction and repair.
British journal of rheumatology 1992;31(10):653-61.
1992: Deleuran B W; Chu C Q; Field M; Brennan F M; Mitchell T; Feldmann M; Maini R N
Localization of tumor necrosis factor receptors in the synovial tissue and cartilage-pannus junction in patients with rheumatoid arthritis. Implications for local actions of tumor necrosis factor alpha.
Arthritis and rheumatism 1992;35(10):1170-8.
1992: Cope A P; Aderka D; Doherty M; Engelmann H; Gibbons D; Jones A C; Brennan F M; Maini R N; Wallach D; Feldmann M
Increased levels of soluble tumor necrosis factor receptors in the sera and synovial fluid of patients with rheumatic diseases.
Arthritis and rheumatism 1992;35(10):1160-9.
1992: Sadeghi R; Hawrylowicz C M; Chernajovsky Y; Feldmann M
Synergism of glucocorticoids with granulocyte macrophage colony stimulating factor (GM-CSF) but not interferon gamma (IFN-gamma) or interleukin-4 (IL-4) on induction of HLA class II expression on human monocytes.
Cytokine 1992;4(4):287-97.
1992: Sadeghi R; Feldmann M; Hawrylowicz C
Upregulation of HLA class II, but not intercellular adhesion molecule 1 (ICAM-1) by granulocyte-macrophage colony stimulating factor (GM-CSF) or interleukin-3 (IL-3) in synergy with dexamethasone.
European cytokine network 1992;3(4):373-80.
1992: Brennan F M; Gibbons D L; Mitchell T; Cope A P; Maini R N; Feldmann M
Enhanced expression of tumor necrosis factor receptor mRNA and protein in mononuclear cells isolated from rheumatoid arthritis synovial joints.
European journal of immunology 1992;22(7):1907-12.
1992: Brennan F M; Maini R N; Feldmann M
TNF alpha--a pivotal role in rheumatoid arthritis?
British journal of rheumatology 1992;31(5):293-8.
1992: Feldmann M; Dayan C; Rapoport B; Londei M
T cell activation and antigen presentation in human thyroid autoimmunity.
Journal of autoimmunity 1992;5 Suppl A():115-21.
1992: Zheng R Q; Abney E R; Chu C Q; Field M; Maini R N; Lamb J R; Feldmann M
Detection of in vivo production of tumour necrosis factor-alpha by human thyroid epithelial cells.
Immunology 1992;75(3):456-62.
1992: Feldmann M; Dayan C; Grubeck-Loebenstein B; Rapoport B; Londei M
Mechanism of Graves thyroiditis: implications for concepts and therapy of autoimmunity.
International reviews of immunology 1992;9(2):91-106.
1992: Dayan C M; Feldmann M; Rapoport B; Londei M
Autoimmune thyroiditis and targeted anti-T cell immunotherapy in man.
Autoimmunity 1992;11(3):189-98.
1992: Feldmann M; Brennan F M; Williams R O; Cope A P; Gibbons D L; Katsikis P D; Maini R N
Evaluation of the role of cytokines in autoimmune disease: the importance of TNF alpha in rheumatoid arthritis.
Progress in growth factor research 1992;4(3):247-55.
1991: Naor D; Essery G; Tarcic N; Kahan M; Feldmann M
Regulatory interactions among autologous T cell clones. Human bifunctional T cell clones regulate the activity of an autologous T cell clone.
Annals of the New York Academy of Sciences 1991;636():135-46.
1991: Chu C Q; Field M; Abney E; Zheng R Q; Allard S; Feldmann M; Maini R N
Transforming growth factor-beta 1 in rheumatoid synovial membrane and cartilage/pannus junction.
Clinical and experimental immunology 1991;86(3):380-6.
1991: Haworth C; Brennan F M; Chantry D; Turner M; Maini R N; Feldmann M
Expression of granulocyte-macrophage colony-stimulating factor in rheumatoid arthritis: regulation by tumor necrosis factor-alpha.
European journal of immunology 1991;21(10):2575-9.
1991: Hawrylowicz C M; Howells G L; Feldmann M
Platelet-derived interleukin 1 induces human endothelial adhesion molecule expression and cytokine production.
The Journal of experimental medicine 1991;174(4):785-90.
1991: Dayan C M; Londei M; Corcoran A E; Grubeck-Loebenstein B; James R F; Rapoport B; Feldmann M
Autoantigen recognition by thyroid-infiltrating T cells in Graves disease.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(16):7415-9.
1991: Turner M; Chantry D; Katsikis P; Berger A; Brennan F M; Feldmann M
Induction of the interleukin 1 receptor antagonist protein by transforming growth factor-beta.
European journal of immunology 1991;21(7):1635-9.
1991: Barrett K; Taylor-Fishwick D A; Cope A P; Kissonerghis A M; Gray P W; Feldmann M; Foxwell B M
Cloning, expression and cross-linking analysis of the murine p55 tumor necrosis factor receptor.
European journal of immunology 1991;21(7):1649-56.
1991: Kontiainen S; Toomath R; Lowder J; Feldmann M
Selective activation of T cells in newly diagnosed insulin-dependent diabetic patients: evidence for heterogeneity of T cell receptor usage.
Clinical and experimental immunology 1991;83(3):347-51.
1991: Feldmann M; Brennan F M; Chantry D; Haworth C; Turner M; Katsikis P; Londei M; Abney E; Buchan G; Barrett K
Cytokine assays: role in evaluation of the pathogenesis of autoimmunity.
Immunological reviews 1991;119():105-23.
1991: Zheng R Q; Abney E; Chu C Q; Field M; Grubeck-Loebenstein B; Maini R N; Feldmann M
Detection of interleukin-6 and interleukin-1 production in human thyroid epithelial cells by non-radioactive in situ hybridization and immunohistochemical methods.
Clinical and experimental immunology 1991;83(2):314-9.
1991: Howells G; Pham P; Taylor D; Foxwell B; Feldmann M
Interleukin 4 induces interleukin 6 production by endothelial cells: synergy with interferon-gamma.
European journal of immunology 1991;21(1):97-101.
1991: Feldmann M
Cytokine networks: do we understand them well enough to facilitate clinical benefits?
European cytokine network 1991;2(1):5-9.
1991: Brennan F M; Field M; Chu C Q; Feldmann M; Maini R N
Cytokine expression in rheumatoid arthritis.
British journal of rheumatology 1991;30 Suppl 1():76-80.
1990: Zheng R Q; Abney E R; Grubeck-Loebenstein B; Dayan C; Maini R N; Feldmann M
Expression of intercellular adhesion molecule-1 and lymphocyte function-associated antigen-3 on human thyroid epithelial cells in Graves' and Hashimoto's diseases.
Journal of autoimmunity 1990;3(6):727-36.
1990: Grubeck-Loebenstein B; Turner M; Pirich K; Kassal H; Londei M; Waldhäusl W; Feldmann M
CD4+ T-cell clones from autoimmune thyroid tissue cannot be classified according to their lymphokine production.
Scandinavian journal of immunology 1990;32(5):433-40.
1990: Gray P W; Barrett K; Chantry D; Turner M; Feldmann M
Cloning of human tumor necrosis factor (TNF) receptor cDNA and expression of recombinant soluble TNF-binding protein.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(19):7380-4.
1990: Brennan F M; Zachariae C O; Chantry D; Larsen C G; Turner M; Maini R N; Matsushima K; Feldmann M
Detection of interleukin 8 biological activity in synovial fluids from patients with rheumatoid arthritis and production of interleukin 8 mRNA by isolated synovial cells.
European journal of immunology 1990;20(9):2141-4.
1990: Naor D; Essery G; Tarcic N; Kahan M; Lamb J R; Feldmann M
Specific interactions between a human CD4+ clone and autologous CD4+ bifunctional immunoregulatory clones.
Immunological reviews 1990;116():63-83.
1990: Naor D; Essery G; Tarcic N; Kahan M; Feldmann M
Interactions between autologous T cell clones.
Cellular immunology 1990;128(2):490-502.
1990: Maini R N; Plater-Zyberk C; Brown C M; Aghamohammadi S; Brennan F M; Feldmann M
CD5+B cells in rheumatoid arthritis and Sjögren's syndrome.
Clinical and experimental rheumatology 1990;8 Suppl 5():67-8.
1990: Feldmann M; Brennan F M; Chantry D; Haworth C; Turner M; Abney E; Buchan G; Barrett K; Barkley D; Chu A
Cytokine production in the rheumatoid joint: implications for treatment.
Annals of the rheumatic diseases 1990;49 Suppl 1():480-6.
1990: Turner M; Chantry D; Feldmann M
Transforming growth factor beta induces the production of interleukin 6 by human peripheral blood mononuclear cells.
Cytokine 1990;2(3):211-6.
1990: Londei M; Verhoef A; Hawrylowicz C; Groves J; De Berardinis P; Feldmann M
Interleukin 7 is a growth factor for mature human T cells.
European journal of immunology 1990;20(2):425-8.
1990: Chantry D; Turner M; Brennan F; Kingsbury A; Feldmann M
Granulocyte-macrophage colony stimulating factor induces both HLA-DR expression and cytokine production by human monocytes.
Cytokine 1990;2(1):60-7.
1990: Todd I; Hammond L J; James R F; Feldmann M; Bottazzo G F
Epidermal growth factor and transforming growth factor-alpha suppress HLA class II induction in human thyroid epithelial cells.
Immunology 1990;69(1):91-6.
1990: Varma C; Chantry D; Brennan F; Turner M; Katz F; Feldmann M
Interleukin 7 and interleukin 4 stimulate human thymocyte growth through distinct mechanisms.
Cytokine 1990;2(1):55-9.
1989: Turner M; Chantry D; Buchan G; Barrett K; Feldmann M
Regulation of expression of human IL-1 alpha and IL-1 beta genes.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(11):3556-61.
1989: Londei M; Verhoef A; De Berardinis P; Kissonerghis M; Grubeck-Loebenstein B; Feldmann M
Definition of a population of CD4-8- T cells that express the alpha beta T-cell receptor and respond to interleukins 2, 3, and 4.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(21):8502-6.
1989: Partridge M; Green M R; Langdon J D; Feldmann M
Production of TGF-alpha and TGF-beta by cultured keratinocytes, skin and oral squamous cell carcinomas--potential autocrine regulation of normal and malignant epithelial cell proliferation.
British journal of cancer 1989;60(4):542-8.
1989: Grubeck-Loebenstein B; Buchan G; Chantry D; Kassal H; Londei M; Pirich K; Barrett K; Turner M; Waldhausl W; Feldmann M
Analysis of intrathyroidal cytokine production in thyroid autoimmune disease: thyroid follicular cells produce interleukin-1 alpha and interleukin-6.
Clinical and experimental immunology 1989;77(3):324-30.
1989: Brennan F; Plater-Zyberk C; Maini R N; Feldmann M
Coordinate expansion of 'fetal type' lymphocytes (TCR gamma delta+T and CD5+B) in rheumatoid arthritis and primary Sjögren's syndrome.
Clinical and experimental immunology 1989;77(2):175-8.
1989: Brennan F M; Chantry D; Jackson A; Maini R; Feldmann M
Inhibitory effect of TNF alpha antibodies on synovial cell interleukin-1 production in rheumatoid arthritis.
Lancet 1989;2(8657):244-7.
1989: Hewitt C R; Feldmann M
Human T cell clones present antigen.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(2):762-9.
1989: Grubeck-Loebenstein B; Buchan G; Chantry D; Turner M; Londei M; Feldmann M
Intrathyroidal cytokine production in thyroid disease.
Journal of autoimmunity 1989;2 Suppl():171-6.
1989: Naor D; Essery G; Kahan M; Feldmann M
T-cell clone anti-clone interactions. Effects on suppressor and helper activities.
Journal of autoimmunity 1989;2 Suppl():3-14.
1989: Chantry D; Turner M; Abney E; Feldmann M
Modulation of cytokine production by transforming growth factor-beta.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(12):4295-300.
1989: Brennan F M; Chantry D; Jackson A M; Maini R N; Feldmann M
Cytokine production in culture by cells isolated from the synovial membrane.
Journal of autoimmunity 1989;2 Suppl():177-86.
1989: Plater-Zyberk C; Brennan F M; Feldmann M; Maini R N
'Fetal-type' B and T lymphocytes in rheumatoid arthritis and primary Sjögren's syndrome.
Journal of autoimmunity 1989;2 Suppl():233-41.
1989: Chantry D; Turner M; Feldmann M
Interleukin 7 (murine pre-B cell growth factor/lymphopoietin 1) stimulates thymocyte growth: regulation by transforming growth factor beta.
European journal of immunology 1989;19(4):783-6.
1989: De Berardinis P; Londei M; James R F; Lake S P; Wise P H; Feldmann M
CD4+ T-cell damage to islet beta cells.
Lancet 1989;1(8633):329.
1989: Portillo G; Turner M; Chantry D; Feldmann M
Effect of cytokines on HLA-DR and IL-1 production by a monocytic tumour, THP-1.
Immunology 1989;66(2):170-5.
1989: Kissonerghis A M; Maini R N; Feldmann M
High rate of HLA class II mRNA synthesis in rheumatoid arthritis joints and its persistence in culture: down-regulation by recombinant interleukin 2.
Scandinavian journal of immunology 1989;29(1):73-82.
1989: Chantry D; Winearls C G; Maini R N; Feldmann M
Mechanism of immune complex-mediated damage: induction of interleukin 1 by immune complexes and synergy with interferon-gamma and tumor necrosis factor-alpha.
European journal of immunology 1989;19(1):189-92.
1989: Londei M; Savill C M; Verhoef A; Brennan F; Leech Z A; Duance V; Maini R N; Feldmann M
Persistence of collagen type II-specific T-cell clones in the synovial membrane of a patient with rheumatoid arthritis.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(2):636-40.
1989: Feldmann M
Molecular mechanisms involved in human autoimmune diseases: relevance of chronic antigen presentation. Class II expression and cytokine production.
Immunology. Supplement 1989;2():66-71; discussion 72-3.
1989: Kissonerghis A M; Grubeck-Loebenstein B; Pirich K; Feldmann M; Londei M
Tumour necrosis factor synergises with gamma interferon on the induction of mRNA for DR alpha chain on thyrocytes from Graves' disease and non toxic goitre.
Autoimmunity 1989;4(4):255-66.
1988: Hirano T; Matsuda T; Turner M; Miyasaka N; Buchan G; Tang B; Sato K; Shimizu M; Maini R; Feldmann M
Excessive production of interleukin 6/B cell stimulatory factor-2 in rheumatoid arthritis.
European journal of immunology 1988;18(11):1797-801.
1988: Turner M; Chantry D; Feldmann M
Post-transcriptional control of IL-1 gene expression in the acute monocytic leukemia line THP-1.
Biochemical and biophysical research communications 1988;156(2):830-9.
1988: de Berardinis P; Londei M; James R F; Lake S P; Wise P H; Feldmann M
Do CD4-positive cytotoxic T cells damage islet beta cells in type 1 diabetes?
Lancet 1988;2(8615):823-4.
1988: Buchan G; Barrett K; Turner M; Chantry D; Maini R N; Feldmann M
Interleukin-1 and tumour necrosis factor mRNA expression in rheumatoid arthritis: prolonged production of IL-1 alpha.
Clinical and experimental immunology 1988;73(3):449-55.
1988: Brennan F M; Allard S; Londei M; Savill C; Boylston A; Carrel S; Maini R N; Feldmann M
Heterogeneity of T cell receptor idiotypes in rheumatoid arthritis.
Clinical and experimental immunology 1988;73(3):417-23.
1988: Brennan F M; Londei M; Jackson A M; Hercend T; Brenner M B; Maini R N; Feldmann M
T cells expressing gamma delta chain receptors in rheumatoid arthritis.
Journal of autoimmunity 1988;1(4):319-26.
1988: De Berardinis P; Londei M; Kahan M; Balsano F; Kontiainen S; Gale E A; Bottazzo G F; Feldmann M
The majority of the activated T cells in the blood of insulin-dependent diabetes mellitus (IDDM) patients are CD4+.
Clinical and experimental immunology 1988;73(2):255-9.
1988: De Berardinis P; Londei M; Carrel S; Feldmann M
Regulation of clonal growth by anti-T-cell receptor antibody-directed lysis.
Immunology 1988;64(3):439-43.
1988: Essery G; Feldmann M; Lamb J R
Interleukin-2 can prevent and reverse antigen-induced unresponsiveness in cloned human T lymphocytes.
Immunology 1988;64(3):413-7.
1988: Turner M; Feldmann M
Comparison of patterns of expression of tumour necrosis factor, lymphotoxin and interleukin-6 mRNA.
Biochemical and biophysical research communications 1988;153(3):1144-51.
1988: Grubeck-Loebenstein B; Londei M; Greenall C; Pirich K; Kassal H; Waldhäusl W; Feldmann M
Pathogenetic relevance of HLA class II expressing thyroid follicular cells in nontoxic Goiter and in Graves' disease.
The Journal of clinical investigation 1988;81(5):1608-14.
1988: Feldmann M; Londei M; Grubeck-Loebenstein B; De Berardinis P; Leech Z; Turner M; Barrett K; Buchan G; Maini R N
Understanding what infiltrating cells do in autoimmunity: combination of cellular and molecular approaches.
Transplantation proceedings 1988;20(2):311-4.
1988: Buchan G; Barrett K; Fujita T; Taniguchi T; Maini R; Feldmann M
Detection of activated T cell products in the rheumatoid joint using cDNA probes to Interleukin-2 (IL-2) IL-2 receptor and IFN-gamma.
Clinical and experimental immunology 1988;71(2):295-301.
1988: Londei M; Grubeck-Loebenstein B; de Berardinis P; Greenall C; Feldmann M
Efficient propagation and cloning of human T cells in the absence of antigen by means of OKT3, interleukin 2, and antigen-presenting cells.
Scandinavian journal of immunology 1988;27(1):35-46.
1988: Feldmann M; Londei M; Kissonerghis M; Portillo G; Leech Z; Ziegler A; Grubeck-Loebenstein B
Regulation of HLA class II expression and the pathogenesis of autoimmunity.
Concepts in immunopathology 1988;5():44-56.
1988: Feldmann M; Kissonerghis A M; Buchan G; Brennan F; Turner M; Haworth C; Barrett K; Chantry D; Ziegler A; Maini R N
Role of HLA class II and cytokine expression in rheumatoid arthritis.
Scandinavian journal of rheumatology. Supplement 1988;76():39-46.
1988: Feldmann M; Londei M; Leech Z; Brennan F; Savill C; Maini R N
Analysis of T cell clones in rheumatoid arthritis.
Springer seminars in immunopathology 1988;10(2-3):157-67.
1987: Turner M; Londei M; Feldmann M
Human T cells from autoimmune and normal individuals can produce tumor necrosis factor.
European journal of immunology 1987;17(12):1807-14.
1987: Venkitaraman A R; Culbert E J; Feldmann M
A phenotypically dominant regulatory mechanism suppresses major histocompatibility complex class II gene expression in a murine plasmacytoma.
European journal of immunology 1987;17(10):1441-6.
1987: Todd I; Pujol-Borrell R; Abdul-Karim B A; Hammond L J; Feldmann M; Bottazzo G F
HLA-D subregion expression by thyroid epithelium in autoimmune thyroid diseases and induced in vitro.
Clinical and experimental immunology 1987;69(3):532-42.
1987: Todd I; Pujol-Borrell R; Hammond L J; McNally J M; Feldmann M; Bottazzo G F
Enhancement of thyrocyte HLA class II expression by thyroid stimulating hormone.
Clinical and experimental immunology 1987;69(3):524-31.
1987: Londei M; Grubeck-Loebenstein B; Greenall C; Turner M; Feldmann M
Comparison of the cellular infiltrate of Hashimoto's thyroiditis in vivo and after in vitro cell growth.
Acta endocrinologica. Supplementum 1987;281():86-8.
1987: Londei M; Grubeck-Loebenstein B; Kissonerghis M; Austin P; Trowsdale J; Greenall C; Feldmann M
Thyrocytes can synthesize HLA class II molecules.
Acta endocrinologica. Supplementum 1987;281():82-5.
1987: Feldmann M
Regulation of HLA class II expression and its role in autoimmune disease.
Ciba Foundation symposium 1987;129():88-108.
1987: Feldmann M; Londei M; Buchan G
Interferons and autoimmunity.
Interferon 1987;9():75-90.
1986: Todd I; Londei M; Pujol-Borrell R; Mirakian R; Feldmann M; Bottazzo G F
HLA-D/DR expression on epithelial cells: the finger on the trigger?
Annals of the New York Academy of Sciences 1986;475():241-50.
1986: Bottazzo G F; Londei M; Bosi E; Mirakian R; Belfiore A; De Berardinis P G; Todd I; Pujol-Borrell R; Feldmann M
Inappropriate HLA class II expression on epithelial cells: new insight in the pathogenesis of distinctive autoimmunity.
Annali italiani di medicina interna : organo ufficiale della Società italiana di medicina interna 1986;1 Suppl 1():20-3.
1985: Todd I; Pujol-Borrell R; Hammond L J; Bottazzo G F; Feldmann M
Interferon-gamma induces HLA-DR expression by thyroid epithelium.
Clinical and experimental immunology 1985;61(2):265-73.

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