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Ariel Feldstein

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Naim Alkhouri; Ariel E Feldstein; Rocio Lopez; Massimo Pinzani; Emad Sedki; Anna Alisi; Valerio Nobili
Combined paediatric NAFLD fibrosis index and transient elastography to predict clinically significant fibrosis in children with fatty liver disease.
Naim Alkhouri; Rita De Vito; Ariel E Feldstein; Rocio Lopez; Anna Alisi; Lisa M Yerian; Valerio Nobili
Development and validation of a new histological score for pediatric non-alcoholic fatty liver disease.
Claudia O Zein; Xiaoming Fu; Stanley L Hazen; John P Kirwan; Rocio Lopez; Arthur J McCullough; Lisa M Yerian; Ariel E Feldstein
Pentoxifylline decreases oxidized lipid products in nonalcoholic steatohepatitis: new evidence on the potential therapeutic mechanism.

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All Publications

2013: Naim Alkhouri; Ariel E Feldstein; Rocio Lopez; Massimo Pinzani; Emad Sedki; Anna Alisi; Valerio Nobili
Combined paediatric NAFLD fibrosis index and transient elastography to predict clinically significant fibrosis in children with fatty liver disease.
Liver international : official journal of the International Association for the Study of the Liver 2013;33(1):79-85.
2012: Naim Alkhouri; Rita De Vito; Ariel E Feldstein; Rocio Lopez; Anna Alisi; Lisa M Yerian; Valerio Nobili
Development and validation of a new histological score for pediatric non-alcoholic fatty liver disease.
Journal of hepatology 2012;57(6):1312-8.
2012: Claudia O Zein; Xiaoming Fu; Stanley L Hazen; John P Kirwan; Rocio Lopez; Arthur J McCullough; Lisa M Yerian; Ariel E Feldstein
Pentoxifylline decreases oxidized lipid products in nonalcoholic steatohepatitis: new evidence on the potential therapeutic mechanism.
Hepatology (Baltimore, Md.) 2012;56(4):1291-9.
2012: Tyler Stevens; Renliang Zhang; Rocio Lopez; Mansour A Parsi; Michael P Berk; Mary P Bronner; Yoon-Mi Chung; Ariel E Feldstein
Lipidomic profiling of serum and pancreatic fluid in chronic pancreatitis.
Pancreas 2012;41(4):518-22.
2012: Laura J Dixon; Bettina G Papouchado; Samjhana Thapaliya; Michael Berk; Ariel E Feldstein
Caspase-1-mediated regulation of fibrogenesis in diet-induced steatohepatitis.
Laboratory investigation; a journal of technical methods and pathology 2012;92(5):713-23.
2012: Naim Alkhouri; Ariel E Feldstein
The TONIC trial: a step forward in treating pediatric nonalcoholic fatty liver disease.
Hepatology (Baltimore, Md.) 2012;55(4):1292-5.
2011: Claudia O Zein; Lisa M Yerian; Ariel E Feldstein; Prema Gogate; John P Kirwan; Rocio Lopez; Arthur J McCullough
Pentoxifylline improves nonalcoholic steatohepatitis: a randomized placebo-controlled trial.
Hepatology (Baltimore, Md.) 2011;54(5):1610-9.
2011: Rohit Kohli; Ariel E Feldstein
NASH animal models: are we there yet?
Journal of hepatology 2011;55(4):941-3.
2011: Ariel E Feldstein; Shannon M Bailey
Emerging role of redox dysregulation in alcoholic and nonalcoholic fatty liver disease.
Antioxidants & redox signaling 2011;15(2):421-4.
2011: Tarek I Abu-Rajab Tamimi; Hesham M Elgouhari; Naim Alkhouri; Lisa M Yerian; Michael P Berk; Rocio Lopez; Phillip R Schauer; Nizar N Zein; Ariel E Feldstein
An apoptosis panel for nonalcoholic steatohepatitis diagnosis.
Journal of hepatology 2011;54(6):1224-9.
2011: Zeneng Wang; Elizabeth Klipfell; Brian J Bennett; Robert Koeth; Bruce Levison; Brandon Dugar; Ariel E Feldstein; Earl B Britt; Xiaoming Fu; Yoon-Mi Chung; Yuping Wu; Phil Schauer; Jonathan D Smith; Hooman Allayee; W H Wilson Tang; Joseph A DiDonato; Aldons J Lusis; Stanley L Hazen
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.
Nature 2011;472(7341):57-63.
2011: Naim Alkhouri; Christine Carter-Kent; Ariel E Feldstein
Apoptosis in nonalcoholic fatty liver disease: diagnostic and therapeutic implications.
Expert review of gastroenterology & hepatology 2011;5(2):201-12.
2011: Christine Carter-Kent; Elizabeth M Brunt; Lisa M Yerian; Naim Alkhouri; Paul Angulo; Rohit Kohli; Simon C Ling; Stavra A Xanthakos; Peter F Whitington; Phunchai Charatcharoenwitthaya; Jason Yap; Rocio Lopez; Arthur J McCullough; Ariel E Feldstein
Relations of steatosis type, grade, and zonality to histological features in pediatric nonalcoholic fatty liver disease.
Journal of pediatric gastroenterology and nutrition 2011;52(2):190-7.
2011: Leon A Adams; Ariel E Feldstein
Non-invasive diagnosis of nonalcoholic fatty liver and nonalcoholic steatohepatitis.
Journal of digestive diseases 2011;12(1):10-6.
2011: Naim Alkhouri; Christine Carter-Kent; Rocio Lopez; William M Rosenberg; Massimo Pinzani; Giorgio Bedogni; Ariel E Feldstein; Valerio Nobili
A combination of the pediatric NAFLD fibrosis index and enhanced liver fibrosis test identifies children with fibrosis.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2011;9(2):150-5.
2010: Ariel E Feldstein
Novel insights into the pathophysiology of nonalcoholic fatty liver disease.
Seminars in liver disease 2010;30(4):391-401.
2010: Gareth Morris-Stiff; Ariel E Feldstein
Fibroblast growth factor 21 as a biomarker for NAFLD: integrating pathobiology into clinical practice.
Journal of hepatology 2010;53(5):795-6.
2010: Kadakkal R Radhakrishnan; Naim Alkhouri; Sarah Worley; Susana Arrigain; Vera Hupertz; Marsha Kay; Lisa Yerian; Robert Wyllie; Ariel E Feldstein
Autoimmune hepatitis in children--impact of cirrhosis at presentation on natural history and long-term outcome.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2010;42(10):724-8.
2010: Rohit Kohli; Michelle Kirby; Stavra A Xanthakos; Samir Softic; Ariel E Feldstein; Vijay Saxena; Peter H Tang; Lili Miles; Michael V Miles; William F Balistreri; Stephen C Woods; Randy J Seeley
High-fructose, medium chain trans fat diet induces liver fibrosis and elevates plasma coenzyme Q9 in a novel murine model of obesity and nonalcoholic steatohepatitis.
Hepatology (Baltimore, Md.) 2010;52(3):934-44.
2010: Naim Alkhouri; Tarek Abu-Rajab Tamimi; Lisa M Yerian; Rocio Lopez; Nizar N Zein; Ariel E Feldstein
The inflamed liver and atherosclerosis: a link between histologic severity of nonalcoholic fatty liver disease and increased cardiovascular risk.
Digestive diseases and sciences 2010;55(9):2644-50.
2010: Christine Carter-Kent; Ariel E Feldstein
Non-alcoholic steatohepatitis over multiple generations.
Digestive diseases and sciences 2010;55(5):1494-7.
2010: Naim Alkhouri; Agnieszka Gornicka; Michael P Berk; Samjhana Thapaliya; Laura J Dixon; Sangeeta Kashyap; Philip R Schauer; Ariel E Feldstein
Adipocyte apoptosis, a link between obesity, insulin resistance, and hepatic steatosis.
The Journal of biological chemistry 2010;285(5):3428-38.
2009: Hesham M Elgouhari; Claudia O Zein; Ibrahim Hanouneh; Ariel E Feldstein; Nizar N Zein
Diabetes mellitus is associated with impaired response to antiviral therapy in chronic hepatitis C infection.
Digestive diseases and sciences 2009;54(12):2699-705.
2009: Naim Alkhouri; Rocio Lopez; Michael Berk; Ariel E Feldstein
Serum retinol-binding protein 4 levels in patients with nonalcoholic fatty liver disease.
Journal of clinical gastroenterology 2009;43(10):985-9.
2009: Christine Carter-Kent; Lisa M Yerian; Elizabeth M Brunt; Paul Angulo; Rohit Kohli; Simon C Ling; Stavra A Xanthakos; Peter F Whitington; Phunchai Charatcharoenwitthaya; Jason Yap; Rocio Lopez; Arthur J McCullough; Ariel E Feldstein
Nonalcoholic steatohepatitis in children: a multicenter clinicopathological study.
Hepatology (Baltimore, Md.) 2009;50(4):1113-20.
2009: Ariel E Feldstein; Anna Wieckowska; A Rocio Lopez; Yao-Chang Liu; Nizar N Zein; Arthur J McCullough
Cytokeratin-18 fragment levels as noninvasive biomarkers for nonalcoholic steatohepatitis: a multicenter validation study.
Hepatology (Baltimore, Md.) 2009;50(4):1072-8.
2009: Rui Chen; Ariel E Feldstein; Thomas M McIntyre
Suppression of mitochondrial function by oxidatively truncated phospholipids is reversible, aided by bid, and suppressed by Bcl-XL.
The Journal of biological chemistry 2009;284(39):26297-308.
2009: Sangeeta R Kashyap; Dima L Diab; Allison R Baker; Lisa Yerian; Harpreet Bajaj; Courtney Gray-McGuire; Philip R Schauer; Manjula Gupta; Ariel E Feldstein; Stanley L Hazen; Catherine M Stein
Triglyceride levels and not adipokine concentrations are closely related to severity of nonalcoholic fatty liver disease in an obesity surgery cohort.
Obesity (Silver Spring, Md.) 2009;17(9):1696-701.
2009: Naim Alkhouri; Laura J Dixon; Ariel E Feldstein
Lipotoxicity in nonalcoholic fatty liver disease: not all lipids are created equal.
Expert review of gastroenterology & hepatology 2009;3(4):445-51.
2009: Anna Wieckowska; Bettina G Papouchado; Zhengzheng Li; Rocio Lopez; Nizar N Zein; Ariel E Feldstein
Role of interleukin-6 in human nonalcoholic steatohepatitis. Response to Dogru et al.
The American journal of gastroenterology 2009;104(3):author reply 788.
2009: Zheng Zheng Li; Michael Berk; Thomas M McIntyre; Ariel E Feldstein
Hepatic lipid partitioning and liver damage in nonalcoholic fatty liver disease: role of stearoyl-CoA desaturase.
The Journal of biological chemistry 2009;284(9):5637-44.
2008: Dima L Diab; Lisa Yerian; Philip Schauer; Sangeeta R Kashyap; Rocio Lopez; Stanley L Hazen; Ariel E Feldstein
Cytokeratin 18 fragment levels as a noninvasive biomarker for nonalcoholic steatohepatitis in bariatric surgery patients.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2008;6(11):1249-54.
2008: Ibrahim A Hanouneh; Ariel E Feldstein; Arthur J McCullough; Charles Miller; Federico Aucejo; Lisa Yerian; Rocio Lopez; Nizar N Zein
The significance of metabolic syndrome in the setting of recurrent hepatitis C after liver transplantation.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2008;14(9):1287-93.
2008: Anna Wieckowska; Bettina G Papouchado; ZhengZheng Li; Rocio Lopez; Nizar N Zein; Ariel E Feldstein
Increased hepatic and circulating interleukin-6 levels in human nonalcoholic steatohepatitis.
The American journal of gastroenterology 2008;103(6):1372-9.
2008: Ibrahim A Hanouneh; Ariel E Feldstein; Rocio Lopez; Lisa Yerian; Anjana Pillai; Claudia O Zein; Nizar N Zein
Clinical significance of metabolic syndrome in the setting of chronic hepatitis C virus infection.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2008;6(5):584-9.
2008: ZhengZheng Li; Michael Berk; Thomas M McIntyre; Gregory J Gores; Ariel E Feldstein
The lysosomal-mitochondrial axis in free fatty acid-induced hepatic lipotoxicity.
Hepatology (Baltimore, Md.) 2008;47(5):1495-503.
2008: Christine Carter-Kent; Nizar N Zein; Ariel E Feldstein
Cytokines in the pathogenesis of fatty liver and disease progression to steatohepatitis: implications for treatment.
The American journal of gastroenterology 2008;103(4):1036-42.
2007: Christine Carter-Kent; Kadakkal Radhakrishnan; Ariel E Feldstein
Increasing calories, decreasing morbidity and mortality: is improved nutrition the answer to better outcomes in patients with biliary atresia?
Hepatology (Baltimore, Md.) 2007;46(5):1329-31.
2007: Anna Wieckowska; Arthur J McCullough; Ariel E Feldstein
Noninvasive diagnosis and monitoring of nonalcoholic steatohepatitis: present and future.
Hepatology (Baltimore, Md.) 2007;46(2):582-9.
2006: Anna Wieckowska; Nizar N Zein; Lisa M Yerian; A Rocio Lopez; Arthur J McCullough; Ariel E Feldstein
In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease.
Hepatology (Baltimore, Md.) 2006;44(1):27-33.
2006: Ariel E Feldstein; Nathan W Werneburg; Zhengzheng Li; Steven F Bronk; Gregory J Gores
Bax inhibition protects against free fatty acid-induced lysosomal permeabilization.
American journal of physiology. Gastrointestinal and liver physiology 2006;290(6):G1339-46.
2005: Anna Wieckowska; Ariel E Feldstein
Nonalcoholic fatty liver disease in the pediatric population: a review.
Current opinion in pediatrics 2005;17(5):636-41.
2005: Leon A Adams; James F Lymp; Jenny St Sauver; Schuyler O Sanderson; Keith D Lindor; Ariel E Feldstein; Paul Angulo
The natural history of nonalcoholic fatty liver disease: a population-based cohort study.
Gastroenterology 2005;129(1):113-21.
2005: Ariel E Feldstein; Bettina G Papouchado; Paul Angulo; Schyler Sanderson; Leon Adams; Gregory J Gores
Hepatic stellate cells and fibrosis progression in patients with nonalcoholic fatty liver disease.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2005;3(4):384-9.
2005: Ariel E Feldstein; Gregory J Gores
Apoptosis in alcoholic and nonalcoholic steatohepatitis.
Frontiers in bioscience : a journal and virtual library 2005;10():3093-9.
2004: Ariel E Feldstein; Gregory J Gores
An apoptosis biomarker goes to the HCV clinic.
Hepatology (Baltimore, Md.) 2004;40(5):1044-6.
2004: Ariel E Feldstein; Nathan W Werneburg; Ali Canbay; Maria Eugenia Guicciardi; Steven F Bronk; Robert Rydzewski; Lawrence J Burgart; Gregory J Gores
Free fatty acids promote hepatic lipotoxicity by stimulating TNF-alpha expression via a lysosomal pathway.
Hepatology (Baltimore, Md.) 2004;40(1):185-94.
2004: Leon A Adams; Ariel E Feldstein; Keith D Lindor; Paul Angulo
Nonalcoholic fatty liver disease among patients with hypothalamic and pituitary dysfunction.
Hepatology (Baltimore, Md.) 2004;39(4):909-14.
2004: Ali Canbay; Ariel E Feldstein; Edwina S Baskin-Bey; Steven F Bronk; Gregory J Gores
The caspase inhibitor IDN-6556 attenuates hepatic injury and fibrosis in the bile duct ligated mouse.
The Journal of pharmacology and experimental therapeutics 2004;308(3):1191-6.
2003: Ariel E Feldstein; Ali Canbay; Maria Eugenia Guicciardi; Hajime Higuchi; Steven F Bronk; Gregory J Gores
Diet associated hepatic steatosis sensitizes to Fas mediated liver injury in mice.
Journal of hepatology 2003;39(6):978-83.
2003: Ali Canbay; Ariel E Feldstein; Hajime Higuchi; Nathan W Werneburg; Annette Grambihler; Steven F Bronk; Gregory J Gores
Kupffer cell engulfment of apoptotic bodies stimulates death ligand and cytokine expression.
Hepatology (Baltimore, Md.) 2003;38(5):1188-98.
2003: Ariel E Feldstein; Ali Canbay; Paul Angulo; Makiko Taniai; Lawrence J Burgart; Keith D Lindor; Gregory J Gores
Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis.
Gastroenterology 2003;125(2):437-43.
2003: Ali Canbay; Maria Eugenia Guicciardi; Hajime Higuchi; Ariel E Feldstein; Steven F Bronk; Robert Rydzewski; Makiko Taniai; Gregory J Gores
Cathepsin B inactivation attenuates hepatic injury and fibrosis during cholestasis.
The Journal of clinical investigation 2003;112(2):152-9.
2003: Ariel E Feldstein; Jean Perrault; Mounif El-Youssif; Keith D Lindor; Deborah K Freese; Paul Angulo
Primary sclerosing cholangitis in children: a long-term follow-up study.
Hepatology (Baltimore, Md.) 2003;38(1):210-7.
2003: Ariel E Feldstein; Steven M Miller; Mounif El-Youssef; David A Rodeberg; Noralane M Lindor; Lawrence J Burgart; Joseph H Szurszewski; Gianrico Farrugia
Chronic intestinal pseudoobstruction associated with altered interstitial cells of cajal networks.
Journal of pediatric gastroenterology and nutrition 2003;36(4):492-7.
2003: Ariel E Feldstein; Raymund R Razonable; Thomas G Boyce; Deborah K Freese; Mounif El-Youssef; Jean Perrault; Carlos V Paya; Michael B Ishitani
Prevalence and clinical significance of human herpesviruses 6 and 7 active infection in pediatric liver transplant patients.
Pediatric transplantation 2003;7(2):125-9.