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Philip Felgner

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Protein Array Analysis

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Mina Kalantari-Dehaghi; Kristin M Leiferman; Li Liang; Steve Marchenko; Rie Nakajima-Sasaki; Mark R Pittelkow; John J Zone; Grant J Anhalt; Michael J Camilleri; Alexander I Chernyavsky; Sookhee Chun; Philip L Felgner; Algis Jasinskas; Sergei A Grando
Pemphigus vulgaris autoantibody profiling by proteomic technique.
Li Liang; Stephen McSorley; Rie Nakajima-Sasaki; Tran Vu Thieu Nga; Stephen Baker; D Huw Davies; Sarah Dunstan; Silvia Juarez; Philip L Felgner
Immune profiling with a Salmonella Typhi antigen microarray identifies new diagnostic biomarkers of human typhoid.
Li Liang; Philip L Felgner
Predicting antigenicity of proteins in a bacterial proteome; a protein microarray and naïve Bayes classification approach.

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2013: Mina Kalantari-Dehaghi; Kristin M Leiferman; Li Liang; Steve Marchenko; Rie Nakajima-Sasaki; Mark R Pittelkow; John J Zone; Grant J Anhalt; Michael J Camilleri; Alexander I Chernyavsky; Sookhee Chun; Philip L Felgner; Algis Jasinskas; Sergei A Grando
Pemphigus vulgaris autoantibody profiling by proteomic technique.
PloS one 2013;8(3):e57587.
2013: Li Liang; Stephen McSorley; Rie Nakajima-Sasaki; Tran Vu Thieu Nga; Stephen Baker; D Huw Davies; Sarah Dunstan; Silvia Juarez; Philip L Felgner
Immune profiling with a Salmonella Typhi antigen microarray identifies new diagnostic biomarkers of human typhoid.
Scientific reports 2013;3():1043.
2012: Li Liang; Philip L Felgner
Predicting antigenicity of proteins in a bacterial proteome; a protein microarray and naïve Bayes classification approach.
Chemistry & biodiversity 2012;9(5):977-90.
2012: Mina Kalantari-Dehaghi; Li Liang; Douglas M Molina; Rie Nakajima-Sasaki; Jozelyn Pablo; Lbachir BenMohamed; Aziz Alami Chentoufi; Sookhee Chun; Gargi Dasgupta; Jiin Felgner; Philip L Felgner; Gary Hermanson; Algis Jasinskas; D Huw Davies
Discovery of potential diagnostic and vaccine antigens in herpes simplex virus 1 and 2 by proteome-wide antibody profiling.
Journal of virology 2012;86(8):4328-39.
2012: Gargi Dasgupta; D Huw Davies; Payam Falatoonzadeh; Philip L Felgner; Mina Kalantari; Chang Hyun Lim; Aziz Alami Chentoufi; Sookhee Chun; Lbachir BenMohamed
Immunodominant "asymptomatic" herpes simplex virus 1 and 2 protein antigens identified by probing whole-ORFome microarrays with serum antibodies from seropositive asymptomatic versus symptomatic individuals.
Journal of virology 2012;86(8):4358-69.
2012: Anthony P Cannella; Philip L Felgner; Eduardo Gotuzzo; Li Liang; Mayuko Saito; Alessandro Sette; Renée M Tsolis; Joseph M Vinetz
Antigen-specific acquired immunity in human brucellosis: implications for diagnosis, prognosis, and vaccine development.
Frontiers in cellular and infection microbiology 2012;2():1.
2011: Xiaolin Tan; Boubacar Traore; Michael Waisberg; Ogobara K Doumbo; Safiatou Doumbo; Rick M Fairhurst; Philip L Felgner; Kassoum Kayentao; Aissata Ongoiba; Peter D Crompton
Hemoglobin S and C heterozygosity enhances neither the magnitude nor breadth of antibody responses to a diverse array of Plasmodium falciparum antigens.
The Journal of infectious diseases 2011;204(11):1750-61.
2011: Alyssa E Barry; Karen P Day; Pierre Baldi; Philip L Felgner; Freya J I Fowkes; Algis Jasinskas; Mina Kalantari-Dehaghi; Matthew A Kayala; Jozelyn Pablo; Peter M Siba; Xiaolin Tan; Livingstone Tavul; Angela Trieu; Denise L Doolan
The stability and complexity of antibody responses to the major surface antigen of Plasmodium falciparum are associated with age in a malaria endemic area.
Molecular & cellular proteomics : MCP 2011;10(11):M111.008326.
2011: Li Liang; Xiaowu Liang; Douglas Molina; W John W Morrow; Rie Nakajima-Sasaki; Jozelyn Pablo; Mayuko Saito; Xiaolin Tan; Renée M Tsolis; Homarh Villaverde; Joseph M Vinetz; Scott Felgner; Robert H Gilman; Eduardo Gotuzzo; Gary Hermanson; Silvia Juarez; D Huw Davies; Philip L Felgner
Systems biology approach predicts antibody signature associated with Brucella melitensis infection in humans.
Journal of proteome research 2011;10(10):4813-24.
2011: Adam Vigil; Chen Chen; Laura R Hendrix; Aarti Jain; Algis Jasinskas; Rie Nakajima-Sasaki; Jozelyn Pablo; James E Samuel; Philip L Felgner
Profiling the humoral immune response of acute and chronic Q fever by protein microarray.
Molecular & cellular proteomics : MCP 2011;10(10):M110.006304.
2011: Li Liang; Xiaolin Tan; Mert Döşkaya; Peter J Bradley; Ayşe Caner; Philip L Felgner; Yüksel Gürüz; Bettina E Hajagos; Algis Jasinskas; Silvia Juarez; Metin Korkmaz; D Huw Davies
Identification of potential serodiagnostic and subunit vaccine antigens by antibody profiling of toxoplasmosis cases in Turkey.
Molecular & cellular proteomics : MCP 2011;10(7):M110.006916.
2011: Zahra Noroozi; Régis Peytavi; Miodrag Micic; Rie Nakajima-Sasaki; Philip L Felgner; Algis Jasinskas; Horacio Kido; Marc J Madou
A multiplexed immunoassay system based upon reciprocating centrifugal microfluidics.
The Review of scientific instruments 2011;82(6):064303.
2011: Duangchan Suwannasaen; Jirawan Mahawantung; Wipada Chaowagul; Direk Limmathurotsakul; Philip L Felgner; Huw Davies; Gregory J Bancroft; Richard Titball; Ganjana Lertmemongkolchai
Human immune responses to Burkholderia pseudomallei characterized by protein microarray analysis.
The Journal of infectious diseases 2011;203(7):1002-11.
2011: Mina Kalantari-Dehaghi; Douglas M Molina; Mandana Farhadieh; W John Morrow; Xiaowu Liang; Philip L Felgner; Sergei A Grando
New targets of pemphigus vulgaris antibodies identified by protein array technology.
Experimental dermatology 2011;20(2):154-6.
2011: Maria I Cruz-Fisher; Chunmei Cheng; Guifeng Sun; Sukumar Pal; Andy Teng; Douglas M Molina; Matthew A Kayala; Adam Vigil; Pierre Baldi; Philip L Felgner; Xiaowu Liang; Luis M de la Maza
Identification of immunodominant antigens by probing a whole Chlamydia trachomatis open reading frame proteome microarray using sera from immunized mice.
Infection and immunity 2011;79(1):246-57.
2010: Christophe N Magnan; Michael Zeller; Matthew A Kayala; Adam Vigil; Arlo Randall; Philip L Felgner; Pierre Baldi
High-throughput prediction of protein antigenicity using protein microarray data.
Bioinformatics (Oxford, England) 2010;26(23):2936-43.
2010: Adam Vigil; Rocio Ortega; Rie Nakajima-Sasaki; Jozelyn Pablo; Douglas M Molina; Chien-Chung Chao; Hua-Wei Chen; Wei-Mei Ching; Philip L Felgner
Genome-wide profiling of humoral immune response to Coxiella burnetii infection by protein microarray.
Proteomics 2010;10(12):2259-69.
2010: Peter D Crompton; Matthew A Kayala; Boubacar Traore; Kassoum Kayentao; Aissata Ongoiba; Greta E Weiss; Douglas M Molina; Chad R Burk; Michael Waisberg; Algis Jasinskas; Xiaolin Tan; Safiatou Doumbo; Didier Doumtabe; Younoussou Kone; David Narum; Xiaowu Liang; Ogobara K Doumbo; Louis H Miller; Denise L Doolan; Pierre Baldi; Philip L Felgner; Susan K Pierce
A prospective analysis of the Ab response to Plasmodium falciparum before and after a malaria season by protein microarray.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(15):6958-63.
2010: Douglas M Molina; Sukumar Pal; Mathew A Kayala; Andy Teng; Paul J Kim; Pierre Baldi; Philip L Felgner; Xiaowu Liang; Luis M de la Maza
Identification of immunodominant antigens of Chlamydia trachomatis using proteome microarrays.
Vaccine 2010;28(17):3014-24.
2010: Adam Vigil; D Huw Davies; Philip L Felgner
Defining the humoral immune response to infectious agents using high-density protein microarrays.
Future microbiology 2010;5(2):241-51.
2010: Adam Vigil; Rocio Ortega; Aarti Jain; Rie Nakajima-Sasaki; Xiaolin Tan; Bruno B Chomel; Rickie W Kasten; Jane E Koehler; Philip L Felgner
Identification of the feline humoral immune response to Bartonella henselae infection by protein microarray.
PloS one 2010;5(7):e11447.
2010: Li Liang; Diana Leng; Chad Burk; Rie Nakajima-Sasaki; Matthew A Kayala; Vidya L Atluri; Jozelyn Pablo; Berkay Unal; Thomas A Ficht; Eduardo Gotuzzo; Mayuko Saito; W John W Morrow; Xiaowu Liang; Pierre Baldi; Robert H Gilman; Joseph M Vinetz; Renée M Tsolis; Philip L Felgner
Large scale immune profiling of infected humans and goats reveals differential recognition of Brucella melitensis antigens.
PLoS neglected tropical diseases 2010;4(5):e673.
2009: Lichen Jing; Stella Mayo McCaughey; D Huw Davies; Tiana M Chong; Philip L Felgner; Stephen C De Rosa; Christopher B Wilson; David M Koelle
ORFeome approach to the clonal, HLA allele-specific CD4 T-cell response to a complex pathogen in humans.
Journal of immunological methods 2009;347(1-2):36-45.
2009: Philip L Felgner; Matthew A Kayala; Adam Vigil; Chad Burk; Rie Nakajima-Sasaki; Jozelyn Pablo; Douglas M Molina; Siddiqua Hirst; Janet S W Chew; Dongling Wang; Gladys Tan; Melanie Duffield; Ron Yang; Julien Neel; Narisara Chantratita; Gregory J Bancroft; Ganjana Lertmemongkolchai; D Huw Davies; Pierre Baldi; Sharon Peacock; Richard Titball
A Burkholderia pseudomallei protein microarray reveals serodiagnostic and cross-reactive antigens.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(32):13499-504.
2008: Paul A Beare; Chen Chen; Timo Bouman; Jozelyn Pablo; Berkay Unal; Diane C Cockrell; Wendy C Brown; Kent D Barbian; Stephen F Porcella; James E Samuel; Philip L Felgner; Robert A Heinzen
Candidate antigens for Q fever serodiagnosis revealed by immunoscreening of a Coxiella burnetii protein microarray.
Clinical and vaccine immunology : CVI 2008;15(12):1771-9.
2008: Denise L Doolan; Yunxiang Mu; Berkay Unal; Suman Sundaresh; Siddiqua Hirst; Conrad Valdez; Arlo Randall; Douglas Molina; Xiaowu Liang; Daniel A Freilich; J Aggrey Oloo; Peter L Blair; Joao C Aguiar; Pierre Baldi; D Huw Davies; Philip L Felgner
Profiling humoral immune responses to P. falciparum infection with protein microarrays.
Proteomics 2008;8(22):4680-94.
2008: Alan G Barbour; Algis Jasinskas; Matthew A Kayala; D Huw Davies; Allen C Steere; Pierre Baldi; Philip L Felgner
A genome-wide proteome array reveals a limited set of immunogens in natural infections of humans and white-footed mice with Borrelia burgdorferi.
Infection and immunity 2008;76(8):3374-89.
2008: Guanghui Chen; Philip L Felgner; Zhibin Guan
Efficient catalytic synthesis of dendritic polymers having internal fluorescence labels for bioconjugation.
Biomacromolecules 2008;9(7):1745-54.
2008: Lichen Jing; D Huw Davies; Tiana M Chong; Sookhee Chun; Christopher L McClurkan; Jay Huang; Brian T Story; Douglas M Molina; Siddiqua Hirst; Philip L Felgner; David M Koelle
An extremely diverse CD4 response to vaccinia virus in humans is revealed by proteome-wide T-cell profiling.
Journal of virology 2008;82(14):7120-34.
2008: Alessandro Sette; Magdalini Moutaftsi; Juan Moyron-Quiroz; Megan M McCausland; D Huw Davies; Robert J Johnston; Bjoern Peters; Mohammed Rafii-El-Idrissi Benhnia; Julia Hoffmann; Hua-Poo Su; Kavita Singh; David N Garboczi; Steven Head; Howard Grey; Philip L Felgner; Shane Crotty
Selective CD4+ T cell help for antibody responses to a large viral pathogen: deterministic linkage of specificities.
Immunity 2008;28(6):847-58.
2008: Mohammed Rafii-El-Idrissi Benhnia; Megan M McCausland; Hua-Poo Su; Kavita Singh; Julia Hoffmann; D Huw Davies; Philip L Felgner; Steven Head; Alessandro Sette; David N Garboczi; Shane Crotty
Redundancy and plasticity of neutralizing antibody responses are cornerstone attributes of the human immune response to the smallpox vaccine.
Journal of virology 2008;82(7):3751-68.
2008: David P Regis; Carlota Dobaño; Paola Quiñones-Olson; Xiaowu Liang; Norma L Graber; Maureen E Stefaniak; Joseph J Campo; Daniel J Carucci; David A Roth; Huaping He; Philip L Felgner; Denise L Doolan
Transcriptionally active PCR for antigen identification and vaccine development: in vitro genome-wide screening and in vivo immunogenicity.
Molecular and biochemical parasitology 2008;158(1):32-45.
2008: D Huw Davies; Linda S Wyatt; Frances K Newman; Patricia L Earl; Sookhee Chun; Jenny E Hernandez; Douglas M Molina; Siddiqua Hirst; Bernard Moss; Sharon E Frey; Philip L Felgner
Antibody profiling by proteome microarray reveals the immunogenicity of the attenuated smallpox vaccine modified vaccinia virus ankara is comparable to that of Dryvax.
Journal of virology 2008;82(2):652-63.
2007: Jessica R Weaver; Mohammad Shamim; Edward Alexander; D Huw Davies; Philip L Felgner; Stuart N Isaacs
The identification and characterization of a monoclonal antibody to the vaccinia virus E3 protein.
Virus research 2007;130(1-2):269-74.
2007: Zhaohua Lu; Marly I Roche; Julia H Hui; Berkay Unal; Philip L Felgner; Sunita Gulati; Guillermo Madico; Jacqueline Sharon
Generation and characterization of hybridoma antibodies for immunotherapy of tularemia.
Immunology letters 2007;112(2):92-103.
2007: Suman Sundaresh; Arlo Randall; Berkay Unal; Jeannine M Petersen; John Belisle; M Gill Hartley; Melanie Duffield; Richard Titball; D Huw Davies; Philip L Felgner; Pierre Baldi
From protein microarrays to diagnostic antigen discovery: a study of the pathogen Francisella tularensis.
Bioinformatics (Oxford, England) 2007;23(13):i508-18.
2007: Jim E Eyles; Berkay Unal; M Gill Hartley; Sarah L Newstead; Helen Flick-Smith; Joann L Prior; Petra C F Oyston; Arlo Randall; Yunxiang Mu; Siddiqua Hirst; Douglas M Molina; D Huw Davies; Tim Milne; Kate F Griffin; Pierre Baldi; Richard Titball; Philip L Felgner
Immunodominant Francisella tularensis antigens identified using proteome microarray.
Proteomics 2007;7(13):2172-83.
2007: D Huw Davies; Douglas M Molina; Jens Wrammert; Joe Miller; Siddiqua Hirst; Yunxiang Mu; Jozelyn Pablo; Berkay Unal; Rie Nakajima-Sasaki; Xiaowu Liang; Shane Crotty; Kevin L Karem; Inger K Damon; Rafi Ahmed; Luis P Villarreal; Philip L Felgner
Proteome-wide analysis of the serological response to vaccinia and smallpox.
Proteomics 2007;7(10):1678-86.
2007: Mert Döşkaya; Mina Kalantari-Dehaghi; Craig M Walsh; Elzbieta Hiszczyńska-Sawicka; D Huw Davies; Philip L Felgner; Liza S Z Larsen; Richard H Lathrop; G Wesley Hatfield; Jessica R Schulz; Yüksel Gürüz; Frances Jurnak
GRA1 protein vaccine confers better immune response compared to codon-optimized GRA1 DNA vaccine.
Vaccine 2007;25(10):1824-37.
2006: Suman Sundaresh; Denise L Doolan; Siddiqua Hirst; Yunxiang Mu; Berkay Unal; D Huw Davies; Philip L Felgner; Pierre Baldi
Identification of humoral immune responses in protein microarrays using DNA microarray data analysis techniques.
Bioinformatics (Oxford, England) 2006;22(14):1760-6.
2006: Guanghui Chen; Devan Huynh; Philip L Felgner; Zhibin Guan
Tandem chain walking polymerization and atom transfer radical polymerization for efficient synthesis of dendritic nanoparticles for bioconjugation.
Journal of the American Chemical Society 2006;128(13):4298-302.
2005: D Huw Davies; Megan M McCausland; Conrad Valdez; Devan Huynh; Jenny E Hernandez; Yunxiang Mu; Siddiqua Hirst; Luis P Villarreal; Philip L Felgner; Shane Crotty
Vaccinia virus H3L envelope protein is a major target of neutralizing antibodies in humans and elicits protection against lethal challenge in mice.
Journal of virology 2005;79(18):11724-33.
2005: Karen E Isherwood; Richard Titball; D Huw Davies; Philip L Felgner; W John W Morrow
Vaccination strategies for Francisella tularensis.
Advanced drug delivery reviews 2005;57(9):1403-14.
2005: D Huw Davies; Xiaowu Liang; Jenny E Hernandez; Arlo Randall; Siddiqua Hirst; Yunxiang Mu; Kimberly M Romero; Toai T Nguyen; Mina Kalantari-Dehaghi; Shane Crotty; Pierre Baldi; Luis P Villarreal; Philip L Felgner
Profiling the humoral immune response to infection by using proteome microarrays: high-throughput vaccine and diagnostic antigen discovery.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(3):547-52.
2003: Shane Crotty; Philip L Felgner; Huw Davies; John Glidewell; Luis P Villarreal; Rafi Ahmed
Cutting edge: long-term B cell memory in humans after smallpox vaccination.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(10):4969-73.
2003: Denise L Doolan; Joao C Aguiar; Walter R Weiss; Alessandro Sette; Philip L Felgner; D P Regis; P Quinones-Casas; J R Yates; Peter L Blair; Thomas L Richie; Stephen L Hoffman; Daniel J Carucci
Utilization of genomic sequence information to develop malaria vaccines.
The Journal of experimental biology 2003;206(Pt 21):3789-802.
2002: Xiaowu Liang; Andy Teng; Dawn M Braun; Jiin Felgner; Yan Wang; Scott I Baker; Shizong Chen; Olivier Zelphati; Philip L Felgner
Transcriptionally active polymerase chain reaction (TAP): high throughput gene expression using genome sequence data.
The Journal of biological chemistry 2002;277(5):3593-8.
2001: Olivier Zelphati; Y Wang; S Kitada; J C Reed; Philip L Felgner; Jacques Corbeil
Intracellular delivery of proteins with a new lipid-mediated delivery system.
The Journal of biological chemistry 2001;276(37):35103-10.
2000: Olivier Zelphati; Xiaowu Liang; C Nguyen; S Barlow; S Sheng; Z Shao; Philip L Felgner
PNA-dependent gene chemistry: stable coupling of peptides and oligonucleotides to plasmid DNA.
BioTechniques 2000;28(2):304-10, 312-4, 316.
1999: Olivier Zelphati; Xiaowu Liang; P Hobart; Philip L Felgner
Gene chemistry: functionally and conformationally intact fluorescent plasmid DNA.
Human gene therapy 1999;10(1):15-24.
1998: Olivier Zelphati; C Nguyen; M Ferrari; Jiin Felgner; Y Tsai; Philip L Felgner
Stable and monodisperse lipoplex formulations for gene delivery.
Gene therapy 1998;5(9):1272-82.
1998: M E Ferrari; C M Nguyen; Olivier Zelphati; Y Tsai; Philip L Felgner
Analytical methods for the characterization of cationic lipid-nucleic acid complexes.
Human gene therapy 1998;9(3):341-51.
1998: C Frank Bennett; D Mirejovsky; Rosanne M Crooke; Y J Tsai; Jiin Felgner; C N Sridhar; C J Wheeler; Philip L Felgner
Structural requirements for cationic lipid mediated phosphorothioate oligonucleotides delivery to cells in culture.
Journal of drug targeting 1998;5(3):149-62.
1997: JA Norman; Peter Hobart; Marston Manthorpe; Philip L Felgner; C Wheeler
Development of improved vectors for DNA-based immunization and other gene therapy applications.
Vaccine 1997;15(8):801-3.
1997: Michael Hsiao; victor Tse; J Carmel; Y Tsai; Philip L Felgner; Martin Haas; Gerald D Silverberg
Intracavitary liposome-mediated p53 gene transfer into glioblastoma with endogenous wild-type p53 in vivo results in tumor suppression and long-term survival.
Biochemical and biophysical research communications 1997;233(2):359-64.
1996: C J Wheeler; Philip L Felgner; Y J Tsai; John Marshall; L Sukhu; S G Doh; Jukka Hartikka; J Nietupski; Marston Manthorpe; M Nichols; M Plewe; X Liang; Jon Norman; A Smith; Seng Cheng
A novel cationic lipid greatly enhances plasmid DNA delivery and expression in mouse lung.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(21):11454-9.
1996: D J Stephan; ZY Yang; Hong San; Robert D Simari; C J Wheeler; Philip L Felgner; David F Gordon; Gary Nabel; Elizabeth G Nabel
A new cationic liposome DNA complex enhances the efficiency of arterial gene transfer in vivo.
Human gene therapy 1996;7(15):1803-12.
1996: C J Wheeler; L Sukhu; G Yang; Y Tsai; C Bustamente; Philip L Felgner; Jon Norman; Marston Manthorpe
Converting an alcohol to an amine in a cationic lipid dramatically alters the co-lipid requirement, cellular transfection activity and the ultrastructure of DNA-cytofectin complexes.
Biochimica et biophysica acta 1996;1280(1):1-11.
1995: Philip L Felgner; Y J Tsai; L Sukhu; C J Wheeler; Marston Manthorpe; John Marshall; Seng Cheng
Improved cationic lipid formulations for in vivo gene therapy.
Annals of the New York Academy of Sciences 1995;772():126-39.
1995: Philip L Felgner; R H Zaugg; J A Norman
Synthetic recombinant DNA delivery for cancer therapeutics.
Cancer gene therapy 1995;2(1):61-5.
1994: J H Felgner; R Kumar; C N Sridhar; C J Wheeler; Y J Tsai; R Border; P Ramsey; M Martin; Philip L Felgner
Enhanced gene delivery and mechanism studies with a novel series of cationic lipid formulations.
The Journal of biological chemistry 1994;269(4):2550-61.
1994: Gary Nabel; Alfred E Chang; Elizabeth G Nabel; Gregory E Plautz; William D Ensminger; Fox Bernard; Philip L Felgner; Suyu Shu; Kyung J Cho
Immunotherapy for cancer by direct gene transfer into tumors.
Human gene therapy 1994;5(1):57-77.
1993: Hong San; ZY Yang; V J Pompili; M L Jaffe; Gregory E Plautz; Li Xu; J H Felgner; C J Wheeler; Philip L Felgner; Xiang Gao
Safety and short-term toxicity of a novel cationic lipid formulation for human gene therapy.
Human gene therapy 1993;4(6):781-8.