Carolyn Felix

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Felix Carolyn A
A safer regimen for high-risk neuroblastoma.
Robinson Blaine W; Felix Carolyn A
Panhandle PCR approaches to cloning MLL genomic breakpoint junctions and fusion transcript sequences.
Robinson Blaine W; Behling Kathryn C; Gupta Manish; Zhang Alena Y; Moore Jonni S; Bantly Andrew D; Willman Cheryl L; Carroll Andrew J; Adamson Peter C; Barrett Jeffrey S; Felix Carolyn A
Abundant anti-apoptotic BCL-2 is a molecular target in leukaemias with t(4;11) translocation.

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2009: Felix Carolyn A
A safer regimen for high-risk neuroblastoma.
Pediatric blood & cancer 2009;53(1):3-6.
2009: Robinson Blaine W; Felix Carolyn A
Panhandle PCR approaches to cloning MLL genomic breakpoint junctions and fusion transcript sequences.
Methods in molecular biology (Clifton, N.J.) 2009;538():85-114.
2008: Robinson Blaine W; Behling Kathryn C; Gupta Manish; Zhang Alena Y; Moore Jonni S; Bantly Andrew D; Willman Cheryl L; Carroll Andrew J; Adamson Peter C; Barrett Jeffrey S; Felix Carolyn A
Abundant anti-apoptotic BCL-2 is a molecular target in leukaemias with t(4;11) translocation.
British journal of haematology 2008;141(6):827-39.
2008: Robinson Blaine W; Cheung Nai-Kong V; Kolaris Christos P; Jhanwar Suresh C; Choi John K; Osheroff Neil; Felix Carolyn A
Prospective tracing of MLL-FRYL clone with low MEIS1 expression from emergence during neuroblastoma treatment to diagnosis of myelodysplastic syndrome.
Blood 2008;111(7):3802-12.
2006: Zheng Naiyu; Pang Shaokun; Oe Tomoyuki; Felix Carolyn A; Wehrli Suzanne; Blair Ian A
Characterization of an etoposide-glutathione conjugate derived from metabolic activation by human cytochrome p450.
Current drug metabolism 2006;7(8):897-911.
2006: Yocum Anastasia K; Busch Christine M; Felix Carolyn A; Blair Ian A
Proteomics-based strategy to identify biomarkers and pharmacological targets in leukemias with t(4;11) translocations.
Journal of proteome research 2006;5(10):2743-53.
2006: Felix Carolyn A; Kolaris Christos P; Osheroff Neil
Topoisomerase II and the etiology of chromosomal translocations.
DNA repair 2006;5(9-10):1093-108.
2006: Robinson Blaine W; Slater Diana J; Felix Carolyn A
BglII-based panhandle and reverse panhandle PCR approaches increase capability for cloning der(II) and der(other) genomic breakpoint junctions of MLL translocations.
Genes, chromosomes & cancer 2006;45(8):740-53.
2005: Libura Jolanta; Slater Diana J; Felix Carolyn A; Richardson Christine
Therapy-related acute myeloid leukemia-like MLL rearrangements are induced by etoposide in primary human CD34+ cells and remain stable after clonal expansion.
Blood 2005;105(5):2124-31.
2004: Zhuo Xiaoliang; Zheng Naiyu; Felix Carolyn A; Blair Ian A
Kinetics and regulation of cytochrome P450-mediated etoposide metabolism.
Drug metabolism and disposition: the biological fate of chemicals 2004;32(9):993-1000.
2004: Zheng Naiyu; Felix Carolyn A; Pang Shaokun; Boston Ray; Moate Peter; Scavuzzo Jennifer; Blair Ian A
Plasma etoposide catechol increases in pediatric patients undergoing multiple-day chemotherapy with etoposide.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(9):2977-85.
2003: Whitmarsh Ryan J; Saginario Charles; Zhuo Ya; Hilgenfeld Eva; Rappaport Eric F; Megonigal Maureen D; Carroll Martin; Liu Mingli; Osheroff Neil; Cheung Nai-Kong V; Slater Diana J; Ried Thomas; Knutsen Turid; Blair Ian A; Felix Carolyn A
Reciprocal DNA topoisomerase II cleavage events at 5'-TATTA-3' sequences in MLL and AF-9 create homologous single-stranded overhangs that anneal to form der(11) and der(9) genomic breakpoint junctions in treatment-related AML without further processing.
Oncogene 2003;22(52):8448-59.
2002: Smith Martyn T; Wang Yunxia; Skibola Christine F; Slater Diana J; Lo Nigro Luca; Nowell Peter C; Lange Beverly J; Felix Carolyn A
Low NAD(P)H:quinone oxidoreductase activity is associated with increased risk of leukemia with MLL translocations in infants and children.
Blood 2002;100(13):4590-3.
2002: Slater Diana J; Hilgenfeld Eva; Rappaport Eric F; Shah Narayan; Meek Rita G; Williams Wendy Reed; Lovett Brian D; Osheroff Neil; Autar Reshma S; Ried Thomas; Felix Carolyn A
MLL-SEPTIN6 fusion recurs in novel translocation of chromosomes 3, X, and 11 in infant acute myelomonocytic leukaemia and in t(X;11) in infant acute myeloid leukaemia, and MLL genomic breakpoint in complex MLL-SEPTIN6 rearrangement is a DNA topoisomerase II cleavage site.
Oncogene 2002;21(30):4706-14.
2002: Ginsberg Jill P; Orudjev Elmar; Bunin Nancy; Felix Carolyn A; Lange Beverly J
Isolated extramedullary relapse in acute myeloid leukemia: A retrospective analysis.
Medical and pediatric oncology 2002;38(6):387-90.
2002: Leonard Debra G B; Travis Lois B; Addya Kathakali; Dores Graca M; Holowaty Eric J; Bergfeldt Kjell; Malkin David; Kohler Betsy A; Lynch Charles F; Wiklund Tom; Stovall Marilyn; Hall Per; Pukkala Eero; Slater Diana J; Felix Carolyn A
p53 mutations in leukemia and myelodysplastic syndrome after ovarian cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(5):973-85.
2002: Raffini Leslie J; Slater Diana J; Rappaport Eric F; Lo Nigro Luca; Cheung Nai-Kong V; Biegel Jaclyn A; Nowell Peter C; Lange Beverly J; Felix Carolyn A
Panhandle and reverse-panhandle PCR enable cloning of der(11) and der(other) genomic breakpoint junctions of MLL translocations and identify complex translocation of MLL, AF-4, and CDK6.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(7):4568-73.
2001: Lovett B D; Lo Nigro L; Rappaport E F; Blair I A; Osheroff N; Zheng N; Megonigal M D; Williams W R; Nowell P C; Felix C A
Near-precise interchromosomal recombination and functional DNA topoisomerase II cleavage sites at MLL and AF-4 genomic breakpoints in treatment-related acute lymphoblastic leukemia with t(4;11) translocation.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(17):9802-7.
2001: Pang S; Zheng N; Felix C A; Scavuzzo J; Boston R; Blair I A
Simultaneous determination of etoposide and its catechol metabolite in the plasma of pediatric patients by liquid chromatography/tandem mass spectrometry.
Journal of mass spectrometry : JMS 2001;36(7):771-81.
2001: Felix C A
Leukemias related to treatment with DNA topoisomerase II inhibitors.
Medical and pediatric oncology 2001;36(5):525-35.
2001: Lovett B D; Strumberg D; Blair I A; Pang S; Burden D A; Megonigal M D; Rappaport E F; Rebbeck T R; Osheroff N; Pommier Y G; Felix C A
Etoposide metabolites enhance DNA topoisomerase II cleavage near leukemia-associated MLL translocation breakpoints.
Biochemistry 2001;40(5):1159-70.
2000: Pegram L D; Megonigal M D; Lange B J; Nowell P C; Rowley J D; Rappaport E F; Felix C A
t(3;11) translocation in treatment-related acute myeloid leukemia fuses MLL with the GMPS (GUANOSINE 5' MONOPHOSPHATE SYNTHETASE) gene.
Blood 2000;96(13):4360-2.
2000: Megonigal M D; Rappaport E F; Wilson R B; Jones D H; Whitlock J A; Ortega J A; Slater D J; Nowell P C; Felix C A
Panhandle PCR for cDNA: a rapid method for isolation of MLL fusion transcripts involving unknown partner genes.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(17):9597-602.
2000: Megonigal M D; Cheung N K; Rappaport E F; Nowell P C; Wilson R B; Jones D H; Addya K; Leonard D G; Kushner B H; Williams T M; Lange B J; Felix C A
Detection of leukemia-associated MLL-GAS7 translocation early during chemotherapy with DNA topoisomerase II inhibitors.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(6):2814-9.
1999: Felix C A; Hosler M R; Slater D J; Megonigal M D; Lovett B D; Williams T M; Nowell P C; Spinner N B; Owens N L; Hoxie J; Croce C M; Lange B J; Rappaport E F
Duplicated regions of AF-4 intron 4 at t(4;11) translocation breakpoints.
Molecular diagnosis : a journal devoted to the understanding of human disease through the clinical application of molecular biology 1999;4(4):269-83.
1999: Felix C A
Evidence of early start for common acute lymphoblastic leukaemia.
Lancet 1999;354(9189):1486-7.
1999: Felix C A; Lange B J
Leukemia in infants.
The oncologist 1999;4(3):225-40.
1998: Felix C A; Walker A H; Lange B J; Williams T M; Winick N J; Cheung N K; Lovett B D; Nowell P C; Blair I A; Rebbeck T R
Association of CYP3A4 genotype with treatment-related leukemia.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(22):13176-81.
1998: Felix C A
Secondary leukemias induced by topoisomerase-targeted drugs.
Biochimica et biophysica acta 1998;1400(1-3):233-55.
1998: Felix C A; Hosler M R; Slater D J; Parker R I; Masterson M; Whitlock J A; Rebbeck T R; Nowell P C; Lange B J
MLL genomic breakpoint distribution within the breakpoint cluster region in de novo leukemia in children.
Journal of pediatric hematology/oncology : official journal of the American Society of Pediatric Hematology/Oncology 1998;20(4):299-308.
1998: Felix C A; Jones D H
Panhandle PCR: a technical advance to amplify MLL genomic translocation breakpoints.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1998;12(6):976-81.
1998: Felix C A; Megonigal M D; Chervinsky D S; Leonard D G; Tsuchida N; Kakati S; Block A M; Fisher J; Grossi M; Salhany K I; Jani-Sait S N; Aplan P D
Association of germline p53 mutation with MLL segmental jumping translocation in treatment-related leukemia.
Blood 1998;91(12):4451-6.
1998: Megonigal M D; Rappaport E F; Jones D H; Williams T M; Lovett B D; Kelly K M; Lerou P H; Moulton T; Budarf M L; Felix C A
t(11;22)(q23;q11.2) In acute myeloid leukemia of infant twins fuses MLL with hCDCrel, a cell division cycle gene in the genomic region of deletion in DiGeorge and velocardiofacial syndromes.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(11):6413-8.
1998: Megonigal M D; Rappaport E F; Nowell P C; Lange B J; Felix C A
Potential role for wild-type p53 in leukemias with MLL gene translocations.
Oncogene 1998;16(10):1351-6.
1998: Mahgoub N; Parker R I; Hosler M R; Close P; Winick N J; Masterson M; Shannon K M; Felix C A
RAS mutations in pediatric leukemias with MLL gene rearrangements.
Genes, chromosomes & cancer 1998;21(3):270-5.
1997: Felix C A; Kim C S; Megonigal M D; Slater D J; Jones D H; Spinner N B; Stump T; Hosler M R; Nowell P C; Lange B J; Rappaport E F
Panhandle polymerase chain reaction amplifies MLL genomic translocation breakpoint involving unknown partner gene.
Blood 1997;90(12):4679-86.
1997: Megonigal M D; Rappaport E F; Jones D H; Kim C S; Nowell P C; Lange B J; Felix C A
Panhandle PCR strategy to amplify MLL genomic breakpoints in treatment-related leukemias.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(21):11583-8.
1996: Felix C A; Hosler M R; Provisor D; Salhany K; Sexsmith E A; Slater D J; Cheung N K; Winick N J; Strauss E A; Heyn R; Lange B J; Malkin D
The p53 gene in pediatric therapy-related leukemia and myelodysplasia.
Blood 1996;87(10):4376-81.
1995: Felix C A; Slavc I; Dunn M; Strauss E A; Phillips P C; Rorke L B; Sutton L; Bunin G R; Biegel J A
p53 gene mutations in pediatric brain tumors.
Medical and pediatric oncology 1995;25(6):431-6.
1995: Felix C A; Wasserman R; Cesano A; Nowell P C; Hosler M R; Masterson M; Poplack D G; Santoli D
Clonal expansion of germline B-lineage acute lymphoblastic leukemia in severe combined immunodeficient mice.
Oncogene 1995;11(9):1753-9.
1995: Felix C A; Lange B J; Hosler M R; Fertala J; Bjornsti M A
Chromosome band 11q23 translocation breakpoints are DNA topoisomerase II cleavage sites.
Cancer research 1995;55(19):4287-92.
1995: Strauss E A; Hosler M R; Herzog P; Salhany K; Louie R; Felix C A
Complex replication error causes p53 mutation in a Li-Fraumeni family.
Cancer research 1995;55(15):3237-41.
1995: Felix C A; Hosler M R; Winick N J; Masterson M; Wilson A E; Lange B J
ALL-1 gene rearrangements in DNA topoisomerase II inhibitor-related leukemia in children.
Blood 1995;85(11):3250-6.
1994: Felix C A; Wasserman R; Lange B J; Brown D L; Nau M M; Cole D E; Minna J D; Poplack D G
Differentiation stages of childhood acute lymphoblastic leukemias with p53 mutations.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1994;8(6):963-7.
1994: Felix C A; Brown D L; Mitsudomi T; Ikagaki N; Wong A; Wasserman R; Womer R B; Biegel J A
Polymorphism at codon 36 of the p53 gene.
Oncogene 1994;9(1):327-8.
1993: Negrini M; Felix C A; Martin C; Lange B J; Nakamura T; Canaani E; Croce C M
Potential topoisomerase II DNA-binding sites at the breakpoints of a t(9;11) chromosome translocation in acute myeloid leukemia.
Cancer research 1993;53(19):4489-92.
1993: Wasserman R; Felix C A; McKenzie S E; Shane S; Lange B; Finger L R
Identification of an altered immunoglobulin heavy-chain gene rearrangement in the central nervous system in B-precursor acute lymphoblastic leukemia.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1993;7(8):1294-9.
1993: Felix C A; Winick N J; Negrini M; Bowman W P; Croce C M; Lange B J
Common region of ALL-1 gene disrupted in epipodophyllotoxin-related secondary acute myeloid leukemia.
Cancer research 1993;53(13):2954-6.
1993: Perilongo G; Felix C A; Meadows A T; Nowell P; Biegel J; Lange B J
Sequential development of Wilms tumor, T-cell acute lymphoblastic leukemia, medulloblastoma and myeloid leukemia in a child with type 1 neurofibromatosis: a clinical and cytogenetic case report.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1993;7(6):912-5.
1993: Felix C A; Strauss E A; D'Amico D; Tsokos M; Winter S; Mitsudomi T; Nau M M; Brown D L; Leahey A M; Horowitz M E
A novel germline p53 splicing mutation in a pediatric patient with a second malignant neoplasm.
Oncogene 1993;8(5):1203-10.
1992: Felix C A; D'Amico D; Mitsudomi T; Nau M M; Li F P; Fraumeni J F; Cole D E; McCalla J; Reaman G H; Whang-Peng J
Absence of hereditary p53 mutations in 10 familial leukemia pedigrees.
The Journal of clinical investigation 1992;90(2):653-8.
1992: Felix C A; Kappel C C; Mitsudomi T; Nau M M; Tsokos M; Crouch G D; Nisen P D; Winick N J; Helman L J
Frequency and diversity of p53 mutations in childhood rhabdomyosarcoma.
Cancer research 1992;52(8):2243-7.
1992: Felix C A; Nau M M; Takahashi T; Mitsudomi T; Chiba I; Poplack D G; Reaman G H; Cole D E; Letterio J J; Whang-Peng J
Hereditary and acquired p53 gene mutations in childhood acute lymphoblastic leukemia.
The Journal of clinical investigation 1992;89(2):640-7.
1991: Felix C A; Poplack D G
Characterization of acute lymphoblastic leukemia of childhood by immunoglobulin and T-cell receptor gene patterns.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1991;5(12):1015-25.
1990: Felix C A; Poplack D G; Reaman G H; Steinberg S M; Cole D E; Taylor B J; Begley C G; Kirsch I R
Characterization of immunoglobulin and T-cell receptor gene patterns in B-cell precursor acute lymphoblastic leukemia of childhood.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1990;8(3):431-42.
1990: Bertness V L; Felix C A; McBride O W; Morgan R; Smith S D; Sandberg A A; Kirsch I R
Characterization of the breakpoint of a t(14;14)(q11.2;q32) from the leukemic cells of a patient with T-cell acute lymphoblastic leukemia.
Cancer genetics and cytogenetics 1990;44(1):47-54.

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