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Gen-Sheng Feng

Research Profile

Chemicals & Drugs

Living Beings

Physiology

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Publications

TOP 3
Zhao He; Robert R Henry; Kaihong Ji; Philip D King; Shuangwei Li; Marie-Astrid Raquil; Jianhua Shao; Jing Wang; Shufen Wang; Helen H Zhu; Nazilla Alderson; Timothy J Bauler; Theodore Ciaraldi; Gen-Sheng Feng
Nonreceptor tyrosine phosphatase Shp2 promotes adipogenesis through inhibition of p38 MAP kinase.
Shuangwei Li; Hongyang Wang; Diane DiFang Hsu; Gen-Sheng Feng
Dual faces of SH2-containing protein-tyrosine phosphatase Shp2/PTPN11 in tumorigenesis.
Zhao He; Shuangwei Li; Qingyuan Meng; Marie-Astrid Raquil; Liangyou Rui; Jiarui Wu; Hai Zhang; Sharon S Zhang; Helen H Zhu; Nazilla Alderson; Dongsheng Cai; Gen-Sheng Feng
Shp2 controls female body weight and energy balance by integrating leptin and estrogen signals.

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All Publications

2013: Zhao He; Robert R Henry; Kaihong Ji; Philip D King; Shuangwei Li; Marie-Astrid Raquil; Jianhua Shao; Jing Wang; Shufen Wang; Helen H Zhu; Nazilla Alderson; Timothy J Bauler; Theodore Ciaraldi; Gen-Sheng Feng
Nonreceptor tyrosine phosphatase Shp2 promotes adipogenesis through inhibition of p38 MAP kinase.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(1):E79-88.
2012: Shuangwei Li; Hongyang Wang; Diane DiFang Hsu; Gen-Sheng Feng
Dual faces of SH2-containing protein-tyrosine phosphatase Shp2/PTPN11 in tumorigenesis.
Frontiers of medicine 2012;6(3):275-9.
2012: Zhao He; Shuangwei Li; Qingyuan Meng; Marie-Astrid Raquil; Liangyou Rui; Jiarui Wu; Hai Zhang; Sharon S Zhang; Helen H Zhu; Nazilla Alderson; Dongsheng Cai; Gen-Sheng Feng
Shp2 controls female body weight and energy balance by integrating leptin and estrogen signals.
Molecular and cellular biology 2012;32(10):1867-78.
2012: Gen-Sheng Feng
Conflicting roles of molecules in hepatocarcinogenesis: paradigm or paradox.
Cancer cell 2012;21(2):150-4.
2012: Ellinor Haglund; Zhao He; Patricia A Jennings; Gen-Sheng Feng; Joanna I Sułkowska; José N Onuchic
The unique cysteine knot regulates the pleotropic hormone leptin.
PloS one 2012;7(9):e45654.
2011: Zhigang Cai; Gen-Sheng Feng; Xin-Yuan Fu; David L Simons; Samuel M Wu; Xin Zhang
Loss of Shp2-mediated mitogen-activated protein kinase signaling in Muller glial cells results in retinal degeneration.
Molecular and cellular biology 2011;31(14):2973-83.
2011: Helen He Zhu; Kaihong Ji; Nazilla Alderson; Zhao He; Shuangwei Li; Wen Liu; Dong-Er Zhang; Linheng Li; Gen-Sheng Feng
Kit-Shp2-Kit signaling acts to maintain a functional hematopoietic stem and progenitor cell pool.
Blood 2011;117(20):5350-61.
2011: Emilie A Bard-Chapeau; Shuangwei Li; Jin Ding; Sharon S Zhang; Helen H Zhu; Frederic Princen; Diane D Fang; Tao Han; Beatrice Bailly-Maitre; Valeria Poli; Nissi M Varki; Hongyang Wang; Gen-Sheng Feng
Ptpn11/Shp2 acts as a tumor suppressor in hepatocellular carcinogenesis.
Cancer cell 2011;19(5):629-39.
2010: Yi Pan; Christian Carbe; Andrea Powers; Gen-Sheng Feng; Xin Zhang
Sprouty2-modulated Kras signaling rescues Shp2 deficiency during lens and lacrimal gland development.
Development (Cambridge, England) 2010;137(7):1085-93.
2010: Zhigang Cai; Gen-Sheng Feng; Xin Zhang
Temporal requirement of the protein tyrosine phosphatase Shp2 in establishing the neuronal fate in early retinal development.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(11):4110-9.
2009: Kazuki Hagihara; Eric Erquan Zhang; Yue-Hai Ke; Guofa Liu; Jan-Jan Liu; Yi Rao; Gen-Sheng Feng
Shp2 acts downstream of SDF-1alpha/CXCR4 in guiding granule cell migration during cerebellar development.
Developmental biology 2009;334(1):276-84.
2009: Jianxiu Yu; Sharon S Zhang; Kan Saito; Scott Williams; Yutaka Arimura; Yuliang Ma; Yuehai Ke; Véronique Baron; Dan Mercola; Gen-Sheng Feng; Eileen D Adamson; Tomas Mustelin
PTEN regulation by Akt-EGR1-ARF-PTEN axis.
The EMBO journal 2009;28(1):21-33.
2009: Dongmei Wu; Yuhong Pang; Yuehai Ke; Jianxiu Yu; Zhao He; Lutz Tautz; Tomas Mustelin; Sheng Ding; Ziwei Huang; Gen-Sheng Feng
A conserved mechanism for control of human and mouse embryonic stem cell pluripotency and differentiation by shp2 tyrosine phosphatase.
PloS one 2009;4(3):e4914.
2008: Yi Pan; Christian Carbe; Andrea Powers; Eric Erquan Zhang; Jeffrey D Esko; Kay Grobe; Gen-Sheng Feng; Xin Zhang
Bud specific N-sulfation of heparan sulfate regulates Shp2-dependent FGF signaling during lacrimal gland induction.
Development (Cambridge, England) 2008;135(2):301-10.
2007: Yuehai Ke; Eric Erquan Zhang; Kazuki Hagihara; Dongmei Wu; Yuhong Pang; Rüdiger Klein; Tom Curran; Barbara Ranscht; Gen-Sheng Feng
Deletion of Shp2 in the brain leads to defective proliferation and differentiation in neural stem cells and early postnatal lethality.
Molecular and cellular biology 2007;27(19):6706-17.
2007: A R M Ruhul Amin; M Helal Uddin Biswas; Takeshi Senga; Gen-Sheng Feng; Reiji Kannagi; Munna L Agarwal; Michinari Hamaguchi
A role for SHPS-1/SIRPalpha in Concanavalin A-dependent production of MMP-9.
Genes to cells : devoted to molecular & cellular mechanisms 2007;12(9):1023-33.
2007: Yuehai Ke; D Wu; Fred Princen; T Nguyen; Y Pang; Jacqueline Lesperance; William J Muller; Robert Glen Oshima; Gen-Sheng Feng
Role of Gab2 in mammary tumorigenesis and metastasis.
Oncogene 2007;26(34):4951-60.
2007: Ashok Amin; Vijay S Thakur; Rajib K Paul; Gen-Sheng Feng; Cheng-Kui Qu; Hasan Mukhtar; Munna L Agarwal
SHP-2 tyrosine phosphatase inhibits p73-dependent apoptosis and expression of a subset of p53 target genes induced by EGCG.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(13):5419-24.
2007: Rebecca J Chan; Gen-Sheng Feng
PTPN11 is the first identified proto-oncogene that encodes a tyrosine phosphatase.
Blood 2007;109(3):862-7.
2007: Gen-Sheng Feng
Shp2-mediated molecular signaling in control of embryonic stem cell self-renewal and differentiation.
Cell research 2007;17(1):37-41.
2006: Yuehai Ke; Jacqueline Lesperance; Eric Erquan Zhang; Emilie A Bard-Chapeau; Robert Glen Oshima; William J Muller; Gen-Sheng Feng
Conditional deletion of Shp2 in the mammary gland leads to impaired lobulo-alveolar outgrowth and attenuated Stat5 activation.
The Journal of biological chemistry 2006;281(45):34374-80.
2006: Thanh V Nguyen; Yuehai Ke; Eric Erquan Zhang; Gen-Sheng Feng
Conditional deletion of Shp2 tyrosine phosphatase in thymocytes suppresses both pre-TCR and TCR signals.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(9):5990-6.
2006: Emilie A Bard-Chapeau; Jing Yuan; Nathalie M Droin; Shinong Long; Eric Erquan Zhang; Thanh V Nguyen; Gen-Sheng Feng
Concerted functions of Gab1 and Shp2 in liver regeneration and hepatoprotection.
Molecular and cellular biology 2006;26(12):4664-74.
2006: Gen-Sheng Feng
Shp2 as a therapeutic target for leptin resistance and obesity.
Expert opinion on therapeutic targets 2006;10(1):135-42.
2006: Xian-Ping Dong; Xiao-Ming Li; Tian-Ming Gao; Eric Erquan Zhang; Gen-Sheng Feng; Wencheng Xiong; Lin Mei
Shp2 is dispensable in the formation and maintenance of the neuromuscular junction.
Neuro-Signals 2006;15(2):53-63.
2005: Emilie A Bard-Chapeau; Andrea L Hevener; Shinong Long; Eric Erquan Zhang; Jerrold M Olefsky; Gen-Sheng Feng
Deletion of Gab1 in the liver leads to enhanced glucose tolerance and improved hepatic insulin action.
Nature medicine 2005;11(5):567-71.
2004: Eric Erquan Zhang; Emilie Chapeau; Kazuki Hagihara; Gen-Sheng Feng
Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(45):16064-9.
2004: Yingqing Sun; Jing Yuan; Houqi Liu; Zhongqing Shi; Kelly K Baker; Kristiina Vuori; Jie Wu; Gen-Sheng Feng
Role of Gab1 in UV-induced c-Jun NH2-terminal kinase activation and cell apoptosis.
Molecular and cellular biology 2004;24(4):1531-9.
2004: Rebecca J Chan; Min You; Gen-Sheng Feng
Identification of trans-acting factors by electrophoretic mobility shift assay.
Methods in molecular biology (Clifton, N.J.) 2004;249():7-20.
2003: A R M Ruhul Amin; Myat Lin Oo; Takeshi Senga; Noriko Suzuki; Gen-Sheng Feng; Michinari Hamaguchi
SH2 domain containing protein tyrosine phosphatase 2 regulates concanavalin A-dependent secretion and activation of matrix metalloproteinase 2 via the extracellular signal-regulated kinase and p38 pathways.
Cancer research 2003;63(19):6334-9.
2003: Rebecca J Chan; Scott A Johnson; Yanjun Li; Mervin C Yoder; Gen-Sheng Feng
A definitive role of Shp-2 tyrosine phosphatase in mediating embryonic stem cell differentiation and hematopoiesis.
Blood 2003;102(6):2074-80.
2003: Yuhong Chen; Renren Wen; Shoua Yang; James Schuman; Eric Erquan Zhang; Taolin Yi; Gen-Sheng Feng; Demin Wang
Identification of Shp-2 as a Stat5A phosphatase.
The Journal of biological chemistry 2003;278(19):16520-7.
2002: Randy Shen; Ying-Bin Ouyang; Cheng-Kui Qu; Andres Alonso; Lindsey Sperzel; Tomas Mustelin; Mark H Kaplan; Gen-Sheng Feng
Grap negatively regulates T-cell receptor-elicited lymphocyte proliferation and interleukin-2 induction.
Molecular and cellular biology 2002;22(10):3230-6.
2001: Cheng-Kui Qu; S Nguyen; J Chen; Gen-Sheng Feng
Requirement of Shp-2 tyrosine phosphatase in lymphoid and hematopoietic cell development.
Blood 2001;97(4):911-4.
2000: ZQ Shi; DH Yu; M Park; M Marshall; Gen-Sheng Feng
Molecular mechanism for the Shp-2 tyrosine phosphatase function in promoting growth factor stimulation of Erk activity.
Molecular and cellular biology 2000;20(5):1526-36.
1999: C H Kim; Cheng-Kui Qu; Giao Hangoc; Scott Cooper; N Anzai; Gen-Sheng Feng; Hal E Broxmeyer
Abnormal chemokine-induced responses of immature and mature hematopoietic cells from motheaten mice implicate the protein tyrosine phosphatase SHP-1 in chemokine responses.
The Journal of experimental medicine 1999;190(5):681-90.
1999: Cheng-Kui Qu; Wen-Mei Yu; Biagio Azzarelli; Gen-Sheng Feng
Genetic evidence that Shp-2 tyrosine phosphatase is a signal enhancer of the epidermal growth factor receptor in mammals.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(15):8528-33.
1999: Changqing Zhao; DH Yu; R Shen; Gen-Sheng Feng
Gab2, a new pleckstrin homology domain-containing adapter protein, acts to uncouple signaling from ERK kinase to Elk-1.
The Journal of biological chemistry 1999;274(28):19649-54.
1999: M You; DH Yu; Gen-Sheng Feng
Shp-2 tyrosine phosphatase functions as a negative regulator of the interferon-stimulated Jak/STAT pathway.
Molecular and cellular biology 1999;19(3):2416-24.
1998: Cheng-Kui Qu; Wen-Mei Yu; Biagio Azzarelli; S Cooper; Hal E Broxmeyer; Gen-Sheng Feng
Biased suppression of hematopoiesis and multiple developmental defects in chimeric mice containing Shp-2 mutant cells.
Molecular and cellular biology 1998;18(10):6075-82.
1998: DH Yu; Cheng-Kui Qu; O Henegariu; Xu Lu; Gen-Sheng Feng
Protein-tyrosine phosphatase Shp-2 regulates cell spreading, migration, and focal adhesion.
The Journal of biological chemistry 1998;273(33):21125-31.
1998: Xu Lu; Cheng-Kui Qu; ZQ Shi; Gen-Sheng Feng
Downregulation of platelet-derived growth factor receptor-beta in Shp-2 mutant fibroblast cell lines.
Oncogene 1998;17(4):441-8.
1998: Cheng-Kui Qu; Gen-Sheng Feng
Shp-2 has a positive regulatory role in ES cell differentiation and proliferation.
Oncogene 1998;17(4):433-9.
1998: ZQ Shi; Wuyuan Lu; Gen-Sheng Feng
The Shp-2 tyrosine phosphatase has opposite effects in mediating the activation of extracellular signal-regulated and c-Jun NH2-terminal mitogen-activated protein kinases.
The Journal of biological chemistry 1998;273(9):4904-8.
1997: Cheng-Kui Qu; ZQ Shi; R Shen; F Y Tsai; Stuart H Orkin; Gen-Sheng Feng
A deletion mutation in the SH2-N domain of Shp-2 severely suppresses hematopoietic cell development.
Molecular and cellular biology 1997;17(9):5499-507.
1997: T Yin; R Shen; Gen-Sheng Feng; YC Yang
Molecular characterization of specific interactions between SHP-2 phosphatase and JAK tyrosine kinases.
The Journal of biological chemistry 1997;272(2):1032-7.
1996: Tetsuzo Tauchi; J E Damen; K Toyama; Gen-Sheng Feng; H E Broxmeyer; G Krystal
Tyrosine 425 within the activated erythropoietin receptor binds Syp, reduces the erythropoietin required for Syp tyrosine phosphorylation, and promotes mitogenesis.
Blood 1996;87(11):4495-501.
1996: Gen-Sheng Feng; Ying-Bin Ouyang; D P Hu; ZQ Shi; Reiner Gentz; J Ni
Grap is a novel SH3-SH2-SH3 adaptor protein that couples tyrosine kinases to the Ras pathway.
The Journal of biological chemistry 1996;271(21):12129-32.
1995: Douglas Fuhrer; Gen-Sheng Feng; YC Yang
Syp associates with gp130 and Janus kinase 2 in response to interleukin-11 in 3T3-L1 mouse preadipocytes.
The Journal of biological chemistry 1995;270(42):24826-30.
1995: Tetsuzo Tauchi; Gen-Sheng Feng; R Shen; Maureen Hoatlin; Grover C Bagby; David Kabat; L Lu; Hal E Broxmeyer
Involvement of SH2-containing phosphotyrosine phosphatase Syp in erythropoietin receptor signal transduction pathways.
The Journal of biological chemistry 1995;270(10):5631-5.
1994: Tetsuzo Tauchi; Gen-Sheng Feng; Mark S Marshall; R Shen; Charlie Mantel; Tony Pawson; Hal E Broxmeyer
The ubiquitously expressed Syp phosphatase interacts with c-kit and Grb2 in hematopoietic cells.
The Journal of biological chemistry 1994;269(40):25206-11.
1994: Gen-Sheng Feng; R Shen; Hong-Qiang Heng; Lap-Chee Tsui; Andrius Kazlauskas; Tony Pawson
Receptor-binding, tyrosine phosphorylation and chromosome localization of the mouse SH2-containing phosphotyrosine phosphatase Syp.
Oncogene 1994;9(6):1545-50.
1994: Tetsuzo Tauchi; Gen-Sheng Feng; R Shen; H Y Song; David B Donner; Tony Pawson; Hal E Broxmeyer
SH2-containing phosphotyrosine phosphatase Syp is a target of p210bcr-abl tyrosine kinase.
The Journal of biological chemistry 1994;269(21):15381-7.
1994: Gen-Sheng Feng; T Pawson
Phosphotyrosine phosphatases with SH2 domains: regulators of signal transduction.
Trends in genetics : TIG 1994;10(2):54-8.
1993: M Kozlowski; I Mlinaric-Rascan; Gen-Sheng Feng; R Shen; Tony Pawson; Katherine A Siminovitch
Expression and catalytic activity of the tyrosine phosphatase PTP1C is severely impaired in motheaten and viable motheaten mice.
The Journal of experimental medicine 1993;178(6):2157-63.
1993: Andrius Kazlauskas; Gen-Sheng Feng; T Pawson; M Valius
The 64-kDa protein that associates with the platelet-derived growth factor receptor beta subunit via Tyr-1009 is the SH2-containing phosphotyrosine phosphatase Syp.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(15):6939-43.
1993: Gen-Sheng Feng; C C Hui; Tony Pawson
SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinases.
Science (New York, N.Y.) 1993;259(5101):1607-11.
1991: R N Shen; L Lu; Gen-Sheng Feng; J Miller; M W Taylor; Hal E Broxmeyer
Cure with low-dose total-body irradiation of the hematological disorder induced in mice with the Friend virus: possible mechanism involving interferon-gamma and interleukin-2.
Lymphokine and cytokine research 1991;10(1-2):105-9.