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José Fernández-Checa
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38
García-Ruiz, Carmen
36
Colell, Anna
22
Morales, Albert
21
Kaplowitz, Neil
14
Ardite, Esther
11
Marí, Montserrat
6
Ookhtens, Murad
6
Coll, Olga
5
Lluis, Josep
5
Rodés, Juan
4
Panés, Julián
4
Piqué, Josep
4
Miranda, M
4
Ballesta, Antonio
4
Fernandez, Anna Fernandez
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All Publications
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2009: Marí Montserrat; Morales Albert; Colell Anna; García-Ruiz Carmen; Fernández-Checa José C
Mitochondrial glutathione, a key survival antioxidant.
Antioxidants & redox signaling 2009;11(11):2685-700.
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2009: Fernández Anna; Colell Anna; Caballero Francisco; Matías Nuria; García-Ruiz Carmen; Fernández-Checa José C
Mitochondrial S-adenosyl-l-methionine transport is insensitive to alcohol-mediated changes in membrane dynamics.
Alcoholism, clinical and experimental research 2009;33(7):1169-80.
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2009: Fernández Anna; Llacuna Laura; Fernández-Checa José C; Colell Anna
Mitochondrial cholesterol loading exacerbates amyloid beta peptide-induced inflammation and neurotoxicity.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(20):6394-405.
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2009: Llacuna Laura; Marí Montserrat; Lluis Josep M; García-Ruiz Carmen; Fernández-Checa José C; Morales Albert
Reactive oxygen species mediate liver injury through parenchymal nuclear factor-kappaB inactivation in prolonged ischemia/reperfusion.
The American journal of pathology 2009;174(5):1776-85.
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2009: Caballero Francisco; Fernández Anna; De Lacy Antonio M; Fernández-Checa Jose C; Caballería Juan; García-Ruiz Carmen
Enhanced free cholesterol, SREBP-2 and StAR expression in human NASH.
Journal of hepatology 2009;50(4):789-96.
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2009: Moles Anna; Tarrats Núria; Fernández-Checa José C; Marí Montserrat
Cathepsins B and D drive hepatic stellate cell proliferation and promote their fibrogenic potential.
Hepatology (Baltimore, Md.) 2009;49(4):1297-307.
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2008: Montero Joan; Morales Albert; Llacuna Laura; Lluis Josep M; Terrones Oihana; Basañez Gorka; Antonsson Bruno; Prieto Jesús; García-Ruiz Carmen; Colell Anna; Fernández-Checa José C
Mitochondrial cholesterol contributes to chemotherapy resistance in hepatocellular carcinoma.
Cancer research 2008;68(13):5246-56.
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2008: Marí Montserrat; Colell Anna; Morales Albert; Caballero Francisco; Moles Anna; Fernández Anna; Terrones Oihana; Basañez Gorka; Antonsson Bruno; García-Ruiz Carmen; Fernández-Checa José C
Mechanism of mitochondrial glutathione-dependent hepatocellular susceptibility to TNF despite NF-kappaB activation.
Gastroenterology 2008;134(5):1507-20.
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2007: Coll Olga; Morales Albert; Fernández-Checa José C; Garcia-Ruiz Carmen
Neutral sphingomyelinase-induced ceramide triggers germinal vesicle breakdown and oxidant-dependent apoptosis in Xenopus laevis oocytes.
Journal of lipid research 2007;48(9):1924-35.
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2007: Garcia-Ruiz Carmen; Fernández-Checa José C
Redox regulation of hepatocyte apoptosis.
Journal of gastroenterology and hepatology 2007;22 Suppl 1():S38-42.
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2007: Marí Montserrat; Fernández-Checa José C
Sphingolipid signalling and liver diseases.
Liver international : official journal of the International Association for the Study of the Liver 2007;27(4):440-50.
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2007: Rabinovich R A; Bastos R; Ardite E; Llinàs L; Orozco-Levi M; Gea J; Vilaró J; Barberà J A; Rodríguez-Roisin R; Fernández-Checa J C; Roca J
Mitochondrial dysfunction in COPD patients with low body mass index.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2007;29(4):643-50.
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2007: Morales A; París R; Villanueva A; Llacuna L; García-Ruiz C; Fernández-Checa J C
Pharmacological inhibition or small interfering RNA targeting acid ceramidase sensitizes hepatoma cells to chemotherapy and reduces tumor growth in vivo.
Oncogene 2007;26(6):905-16.
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2006: Ardite Esther; Peinado Víctor I; Rabinovich Roberto A; Fernández-Checa José C; Roca Josep; Barberà Joan A
Systemic effects of cigarette smoke exposure in the guinea pig.
Respiratory medicine 2006;100(7):1186-94.
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2005: Gómez-Quiroz Luis Enrique; Paris Raquel; Lluis José María; Bucio Leticia; Souza Verónica; Hernández Elizabeth; Gutiérrez Mario; Santiago Mariana; García-Ruiz Carmen; Fernández-Checa José C; Kershenobich David; Gutiérrez-Ruiz Ma Concepción
Differential modulation of interleukin 8 by interleukin 4 and interleukin 10 in HepG2 cells treated with acetaldehyde.
Liver international : official journal of the International Association for the Study of the Liver 2005;25(1):122-30.
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2004: Ardite Esther; Barbera Joan Albert; Roca Josep; Fernández-Checa Jose C
Glutathione depletion impairs myogenic differentiation of murine skeletal muscle C2C12 cells through sustained NF-kappaB activation.
The American journal of pathology 2004;165(3):719-28.
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2004: Marí Montserrat; Colell Anna; Morales Albert; Pañeda Covadonga; Varela-Nieto Isabel; García-Ruiz Carmen; Fernández-Checa José C
Acidic sphingomyelinase downregulates the liver-specific methionine adenosyltransferase 1A, contributing to tumor necrosis factor-induced lethal hepatitis.
The Journal of clinical investigation 2004;113(6):895-904.
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2004: Colell Anna; García-Ruiz Carmen; Mari Montserrat; Fernández-Checa José C
Mitochondrial permeability transition induced by reactive oxygen species is independent of cholesterol-regulated membrane fluidity.
FEBS letters 2004;560(1-3):63-8.
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2003: Coll Olga; Colell Anna; García-Ruiz Carmen; Kaplowitz Neil; Fernández-Checa J C
Sensitivity of the 2-oxoglutarate carrier to alcohol intake contributes to mitochondrial glutathione depletion.
Hepatology (Baltimore, Md.) 2003;38(3):692-702.
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2003: Colell Anna; García-Ruiz Carmen; Lluis Josep M; Coll Olga; Mari Montse; Fernández-Checa José C
Cholesterol impairs the adenine nucleotide translocator-mediated mitochondrial permeability transition through altered membrane fluidity.
The Journal of biological chemistry 2003;278(36):33928-35.
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2003: Ishii Hiromasa; Adachi Masayuki; Fernández-Checa Jose C; Cederbaum Arthur I; Deaciuc Ion V; Nanji Amin A
Role of apoptosis in alcoholic liver injury.
Alcoholism, clinical and experimental research 2003;27(7):1207-12.
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2003: Fernández-Checa José C
Redox regulation and signaling lipids in mitochondrial apoptosis.
Biochemical and biophysical research communications 2003;304(3):471-9.
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2003: Fernández-Checa José C
Alcohol-induced liver disease: when fat and oxidative stress meet.
Annals of hepatology : official journal of the Mexican Association of Hepatology 2003;2(2):69-75.
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2003: Lluis Josep M; Colell Anna; García-Ruiz Carmen; Kaplowitz Neil; Fernández-Checa José C
Acetaldehyde impairs mitochondrial glutathione transport in HepG2 cells through endoplasmic reticulum stress.
Gastroenterology 2003;124(3):708-24.
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2003: García-Ruiz Carmen; Colell Anna; Marí Montserrat; Morales Albert; Calvo María; Enrich Carlos; Fernández-Checa José C
Defective TNF-alpha-mediated hepatocellular apoptosis and liver damage in acidic sphingomyelinase knockout mice.
The Journal of clinical investigation 2003;111(2):197-208.
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2002: Paris Raquel; Morales Albert; Coll Olga; Sánchez-Reyes Alberto; García-Ruiz Carmen; Fernández-Checa José C
Ganglioside GD3 sensitizes human hepatoma cells to cancer therapy.
The Journal of biological chemistry 2002;277(51):49870-6.
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2002: Neuman Manuela G; Katz Gady G; Malkiewicz Izabella M; Mathurin Philippe; Tsukamoto Hidekazu; Adachi Masayuki; Ishii Hiromasa; Colell Anna; García-Ruiz Carmen; Fernández-Checa José C; Casey Carol A
Alcoholic liver injury and apoptosis--synopsis of the symposium held at ESBRA 2001: 8th Congress of the European Society for Biomedical Research on Alcoholism, Paris, September 16, 2001.
Alcohol (Fayetteville, N.Y.) 2002;28(2):117-28.
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2002: García-Ruiz Carmen; Colell Anna; Morales Albert; Calvo María; Enrich Carlos; Fernández-Checa José C
Trafficking of ganglioside GD3 to mitochondria by tumor necrosis factor-alpha.
The Journal of biological chemistry 2002;277(39):36443-8.
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2002: Colell Anna; Morales Albert; Fernández-Checa José C; García-Ruiz Carmen
Ceramide generated by acidic sphingomyelinase contributes to tumor necrosis factor-alpha-mediated apoptosis in human colon HT-29 cells through glycosphingolipids formation. Possible role of ganglioside GD3.
FEBS letters 2002;526(1-3):135-41.
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2002: Colell Anna; Coll Olga; Mari Montse; Fernández-Checa José C; García-Ruiz Carmen
Divergent role of ceramide generated by exogenous sphingomyelinases on NF-kappa B activation and apoptosis in human colon HT-29 cells.
FEBS letters 2002;526(1-3):15-20.
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2002: Fernández-Checa José C; Colell Anna; García-Ruiz Carmen
S-Adenosyl-L-methionine and mitochondrial reduced glutathione depletion in alcoholic liver disease.
Alcohol (Fayetteville, N.Y.) 2002;27(3):179-83.
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2002: Fernández Checa José C; Bellentani Stefano; Tiribelli Claudio
Alcohol-induced liver disease: from molecular damage to treatment.
Revista médica de Chile 2002;130(6):681-90.
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2002: Quintero A; Pedraza C A; Siendones E; Kamal ElSaid A M; Colell A; García-Ruiz C; Montero J L; De la Mata M; Fernández-Checa J C; Miño G; Muntané J
PGE1 protection against apoptosis induced by D-galactosamine is not related to the modulation of intracellular free radical production in primary culture of rat hepatocytes.
Free radical research 2002;36(3):345-55.
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2001: Colell A; Coll O; García-Ruiz C; París R; Tiribelli C; Kaplowitz N; Fernández-Checa J C
Tauroursodeoxycholic acid protects hepatocytes from ethanol-fed rats against tumor necrosis factor-induced cell death by replenishing mitochondrial glutathione.
Hepatology (Baltimore, Md.) 2001;34(5):964-71.
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2001: Gudayol M; Vidal J; Usac E F; Morales A; Fabregat M E; Fernández-Checa J C; Novials A; Gomis R
Identification and functional analysis of mutations in FAD-binding domain of mitochondrial glycerophosphate dehydrogenase in caucasian patients with type 2 diabetes mellitus.
Endocrine 2001;16(1):39-42.
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2001: Colell A; García-Ruiz C; Roman J; Ballesta A; Fernández-Checa J C
Ganglioside GD3 enhances apoptosis by suppressing the nuclear factor-kappa B-dependent survival pathway.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(6):1068-70.
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2000: García-Ruiz C; Marí M; Morales A; Colell A; Ardite E; Fernández-Checa J C
Human placenta sphingomyelinase, an exogenous acidic pH-optimum sphingomyelinase, induces oxidative stress, glutathione depletion, and apoptosis in rat hepatocytes.
Hepatology (Baltimore, Md.) 2000;32(1):56-65.
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2000: Ardite E; Sans M; Panés J; Romero F J; Piqué J M; Fernández-Checa J C
Replenishment of glutathione levels improves mucosal function in experimental acute colitis.
Laboratory investigation; a journal of technical methods and pathology 2000;80(5):735-44.
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2000: Román J; Giménez A; Lluis J M; Gassó M; Rubio M; Caballeria J; Parés A; Rodés J; Fernández-Checa J C
Enhanced DNA binding and activation of transcription factors NF-kappa B and AP-1 by acetaldehyde in HEPG2 cells.
The Journal of biological chemistry 2000;275(19):14684-90.
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2000: García-Ruiz C; Colell A; París R; Fernández-Checa J C
Direct interaction of GD3 ganglioside with mitochondria generates reactive oxygen species followed by mitochondrial permeability transition, cytochrome c release, and caspase activation.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000;14(7):847-58.
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1999: Román J; Colell A; Blasco C; Caballeria J; Parés A; Rodés J; Fernández-Checa J C
Differential role of ethanol and acetaldehyde in the induction of oxidative stress in HEP G2 cells: effect on transcription factors AP-1 and NF-kappaB.
Hepatology (Baltimore, Md.) 1999;30(6):1473-80.
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1999: Ardite E; Ramos C; Rimola A; Grande L; Fernández-Checa J C
Hepatocellular oxidative stress and initial graft injury in human liver transplantation.
Journal of hepatology 1999;31(5):921-7.
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1999: Sans M; Panés J; Ardite E; Elizalde J I; Arce Y; Elena M; Palacín A; Fernández-Checa J C; Anderson D C; Lobb R; Piqué J M
VCAM-1 and ICAM-1 mediate leukocyte-endothelial cell adhesion in rat experimental colitis.
Gastroenterology 1999;116(4):874-83.
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1998: Colell A; García-Ruiz C; Miranda M; Ardite E; Marí M; Morales A; Corrales F; Kaplowitz N; Fernández-Checa J C
Selective glutathione depletion of mitochondria by ethanol sensitizes hepatocytes to tumor necrosis factor.
Gastroenterology 1998;115(6):1541-51.
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1998: Morales A; Miranda M; Sánchez-Reyes A; Biete A; Fernández-Checa J C
Oxidative damage of mitochondrial and nuclear DNA induced by ionizing radiation in human hepatoblastoma cells.
International journal of radiation oncology, biology, physics 1998;42(1):191-203.
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1998: Bosch-Morell F; Martínez-Soriano F; Colell A; Fernández-Checa J C; Romero F J
Chronic ethanol feeding induces cellular antioxidants decrease and oxidative stress in rat peripheral nerves. Effect of S-adenosyl-L-methionine and N-acetyl-L-cysteine.
Free radical biology & medicine 1998;25(3):365-8.
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1998: Ardite E; Panés J; Miranda M; Salas A; Elizalde J I; Sans M; Arce Y; Bordas J M; Fernández-Checa J C; Piqué J M
Effects of steroid treatment on activation of nuclear factor kappaB in patients with inflammatory bowel disease.
British journal of pharmacology 1998;124(3):431-3.
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1998: Morales A; Miranda M; Sanchez-Reyes A; Colell A; Biete A; Fernández-Checa J C
Transcriptional regulation of the heavy subunit chain of gamma-glutamylcysteine synthetase by ionizing radiation.
FEBS letters 1998;427(1):15-20.
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1998: Fernández-Checa J C; Kaplowitz N; García-Ruiz C; Colell A
Mitochondrial glutathione: importance and transport.
Seminars in liver disease 1998;18(4):389-401.
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1998: Fernández-Checa J C; García-Ruiz C; Colell A; Morales A; Marí M; Miranda M; Ardite E
Oxidative stress: role of mitochondria and protection by glutathione.
BioFactors (Oxford, England) 1998;8(1-2):7-11.
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1997: Barrientos A; Casademont J; Cardellach F; Ardite E; Estivill X; Urbano-Márquez A; Fernández-Checa J C; Nunes V
Qualitative and quantitative changes in skeletal muscle mtDNA and expression of mitochondrial-encoded genes in the human aging process.
Biochemical and molecular medicine 1997;62(2):165-71.
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1997: Morales A; García-Ruiz C; Miranda M; Marí M; Colell A; Ardite E; Fernández-Checa J C
Tumor necrosis factor increases hepatocellular glutathione by transcriptional regulation of the heavy subunit chain of gamma-glutamylcysteine synthetase.
The Journal of biological chemistry 1997;272(48):30371-9.
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1997: Colell A; García-Ruiz C; Morales A; Ballesta A; Ookhtens M; Rodés J; Kaplowitz N; Fernández-Checa J C
Transport of reduced glutathione in hepatic mitochondria and mitoplasts from ethanol-treated rats: effect of membrane physical properties and S-adenosyl-L-methionine.
Hepatology (Baltimore, Md.) 1997;26(3):699-708.
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1997: Fernández-Checa J C; Kaplowitz N; García-Ruiz C; Colell A; Miranda M; Marí M; Ardite E; Morales A
GSH transport in mitochondria: defense against TNF-induced oxidative stress and alcohol-induced defect.
The American journal of physiology 1997;273(1 Pt 1):G7-17.
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1997: Kannan R; Fernández-Checa J C; García-Ruiz C; Mackic J B; Zlokovic B V
Liver and lens glutathione and cysteine regulation in galactose-fed guinea pigs.
Current eye research 1997;16(4):365-71.
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1997: García-Ruiz C; Colell A; Marí M; Morales A; Fernández-Checa J C
Direct effect of ceramide on the mitochondrial electron transport chain leads to generation of reactive oxygen species. Role of mitochondrial glutathione.
The Journal of biological chemistry 1997;272(17):11369-77.
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1997: Goldin E; Ardite E; Elizalde J I; Odriozola A; Panés J; Piqué J M; Fernández-Checa J C
Gastric mucosal damage in experimental diabetes in rats: role of endogenous glutathione.
Gastroenterology 1997;112(3):855-63.
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1997: Fernández-Checa J C; Kaplowitz N; Colell A; García-Ruiz C
Oxidative stress and alcoholic liver disease.
Alcohol health and research world 1997;21(4):321-4.
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1996: Fernández-Checa J C; García-Ruiz C; Colell A; Yi J R; Kaplowitz N
Inhibition of rat sinusoidal GSH transporter by thioethers: specificity, sidedness, and kinetics.
The American journal of physiology 1996;270(6 Pt 1):G969-75.
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1996: Kaplowitz N; Fernández-Checa J C; Kannan R; Garcia-Ruiz C; Ookhtens M; Yi J R
GSH transporters: molecular characterization and role in GSH homeostasis.
Biological chemistry Hoppe-Seyler 1996;377(5):267-73.
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1996: Fernández-Checa J C; Yi J R; García Ruiz C; Ookhtens M; Kaplowitz N
Plasma membrane and mitochondrial transport of hepatic reduced glutathione.
Seminars in liver disease 1996;16(2):147-58.
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1995: García-Ruiz C; Colell A; Morales A; Kaplowitz N; Fernández-Checa J C
Role of oxidative stress generated from the mitochondrial electron transport chain and mitochondrial glutathione status in loss of mitochondrial function and activation of transcription factor nuclear factor-kappa B: studies with isolated mitochondria and rat hepatocytes.
Molecular pharmacology 1995;48(5):825-34.
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1995: García-Ruiz C; Morales A; Colell A; Rodés J; Yi J R; Kaplowitz N; Fernández-Checa J C
Evidence that the rat hepatic mitochondrial carrier is distinct from the sinusoidal and canalicular transporters for reduced glutathione. Expression studies in Xenopus laevis oocytes.
The Journal of biological chemistry 1995;270(27):15946-9.
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1995: Yi J R; Lu S; Fernández-Checa J; Kaplowitz N
Expression cloning of the cDNA for a polypeptide associated with rat hepatic sinusoidal reduced glutathione transport: characteristics and comparison with the canalicular transporter.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(5):1495-9.
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1995: García-Ruiz C; Morales A; Colell A; Ballesta A; Rodés J; Kaplowitz N; Fernández-Checa J C
Feeding S-adenosyl-L-methionine attenuates both ethanol-induced depletion of mitochondrial glutathione and mitochondrial dysfunction in periportal and perivenous rat hepatocytes.
Hepatology (Baltimore, Md.) 1995;21(1):207-14.
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1994: García-Ruiz C; Morales A; Ballesta A; Rodés J; Kaplowitz N; Fernández-Checa J C
Effect of chronic ethanol feeding on glutathione and functional integrity of mitochondria in periportal and perivenous rat hepatocytes.
The Journal of clinical investigation 1994;94(1):193-201.
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1993: Fernández-Checa J C; Hirano T; Tsukamoto H; Kaplowitz N
Mitochondrial glutathione depletion in alcoholic liver disease.
Alcohol (Fayetteville, N.Y.) 1993;10(6):469-75.
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1993: Fernández-Checa J C; Ookhtens M; Kaplowitz N
Selective induction by phenobarbital of the electrogenic transport of glutathione and organic anions in rat liver canalicular membrane vesicles.
The Journal of biological chemistry 1993;268(15):10836-41.
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1993: Fernández-Checa J C; Yi J R; Garcia-Ruiz C; Knezic Z; Tahara S M; Kaplowitz N
Expression of rat liver reduced glutathione transport in Xenopus laevis oocytes.
The Journal of biological chemistry 1993;268(4):2324-8.
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1992: García-Ruiz C; Fernández-Checa J C; Kaplowitz N
Bidirectional mechanism of plasma membrane transport of reduced glutathione in intact rat hepatocytes and membrane vesicles.
The Journal of biological chemistry 1992;267(31):22256-64.
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1992: Fernández-Checa J C; Takikawa H; Horie T; Ookhtens M; Kaplowitz N
Canalicular transport of reduced glutathione in normal and mutant Eisai hyperbilirubinemic rats.
The Journal of biological chemistry 1992;267(3):1667-73.
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1991: Fernández-Checa J C; García-Ruiz C; Ookhtens M; Kaplowitz N
Impaired uptake of glutathione by hepatic mitochondria from chronic ethanol-fed rats. Tracer kinetic studies in vitro and in vivo and susceptibility to oxidant stress.
The Journal of clinical investigation 1991;87(2):397-405.
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1990: Fernández-Checa J C; Kaplowitz N
The use of monochlorobimane to determine hepatic GSH levels and synthesis.
Analytical biochemistry 1990;190(2):212-9.
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