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Pedro Fernandez-Salguero

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Aline Chevallier; Xavier COUMOUL; Pedro Fernandez-Salguero; Antoine Mialot; Jean-Maurice Petit; Robert Barouki; Mathieu Beraneck
Oculomotor deficits in aryl hydrocarbon receptor null mouse.
Shioko Kimura; Mayumi Kawabe; Aiming Yu; Hideki Morishima; Pedro Fernandez-Salguero; George J Hammons; Jerrold M Ward; Fred F Kadlubar; Frank J Gonzalez
Carcinogenesis of the food mutagen PhIP in mice is independent of CYP1A2.
Sudha R Kondraganti; Pedro Fernandez-Salguero; Frank J Gonzalez; Kenneth S Ramos; Weiwu Jiang; Bhagavatula Moorthy
Polycyclic aromatic hydrocarbon-inducible DNA adducts: evidence by 32P-postlabeling and use of knockout mice for Ah receptor-independent mechanisms of metabolic activation in vivo.

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All Publications

2013: Aline Chevallier; Xavier COUMOUL; Pedro Fernandez-Salguero; Antoine Mialot; Jean-Maurice Petit; Robert Barouki; Mathieu Beraneck
Oculomotor deficits in aryl hydrocarbon receptor null mouse.
PloS one 2013;8(1):e53520.
2003: Shioko Kimura; Mayumi Kawabe; Aiming Yu; Hideki Morishima; Pedro Fernandez-Salguero; George J Hammons; Jerrold M Ward; Fred F Kadlubar; Frank J Gonzalez
Carcinogenesis of the food mutagen PhIP in mice is independent of CYP1A2.
Carcinogenesis 2003;24(3):583-7.
2003: Sudha R Kondraganti; Pedro Fernandez-Salguero; Frank J Gonzalez; Kenneth S Ramos; Weiwu Jiang; Bhagavatula Moorthy
Polycyclic aromatic hydrocarbon-inducible DNA adducts: evidence by 32P-postlabeling and use of knockout mice for Ah receptor-independent mechanisms of metabolic activation in vivo.
International journal of cancer. Journal international du cancer 2003;103(1):5-11.
2000: Guillermo Elizondo; Pedro Fernandez-Salguero; M S Sheikh; G Y Kim; Albert J Fornace; Kyung S Lee; Frank J Gonzalez
Altered cell cycle control at the G(2)/M phases in aryl hydrocarbon receptor-null embryo fibroblast.
Molecular pharmacology 2000;57(5):1056-63.
1999: Shioko Kimura; M Kawabe; Jerrold M Ward; Hideki Morishima; Fred F Kadlubar; George J Hammons; Pedro Fernandez-Salguero; Frank J Gonzalez
CYP1A2 is not the primary enzyme responsible for 4-aminobiphenyl-induced hepatocarcinogenesis in mice.
Carcinogenesis 1999;20(9):1825-30.
1999: M Miyata; G Kudo; Y H Lee; TJ Yang; Harry V Gelboin; Pedro Fernandez-Salguero; Shioko Kimura; Frank J Gonzalez
Targeted disruption of the microsomal epoxide hydrolase gene. Microsomal epoxide hydrolase is required for the carcinogenic activity of 7,12-dimethylbenz[a]anthracene.
The Journal of biological chemistry 1999;274(34):23963-8.
1999: Sanna Koskela; Jukka Hakkola; Janne Hukkanen; Olavi Pelkonen; Martti Sorri; A Saranen; Sisko Anttila; Pedro Fernandez-Salguero; F Gonzalez; Hannu Raunio
Expression of CYP2A genes in human liver and extrahepatic tissues.
Biochemical pharmacology 1999;57(12):1407-13.
1999: J M Peters; Michael G Narotsky; Guillermo Elizondo; Pedro Fernandez-Salguero; Frank J Gonzalez; Barbara D Abbott
Amelioration of TCDD-induced teratogenesis in aryl hydrocarbon receptor (AhR)-null mice.
Toxicological sciences : an official journal of the Society of Toxicology 1999;47(1):86-92.
1998: howard mcleod; Elaina Collie-Duguid; P Vreken; Martin R Johnson; X Wei; A Sapone; R B Diasio; Pedro Fernandez-Salguero; A B van Kuilenberg; A H van Gennip; Frank J Gonzalez
Nomenclature for human DPYD alleles.
Pharmacogenetics 1998;8(6):455-9.
1998: Frank J Gonzalez; Pedro Fernandez-Salguero
The aryl hydrocarbon receptor: studies using the AHR-null mice.
Drug metabolism and disposition: the biological fate of chemicals 1998;26(12):1194-8.
1998: Susan A Ridge; J Sludden; O Brown; L Robertson; X Wei; A Sapone; Pedro Fernandez-Salguero; Frank J Gonzalez; P Vreken; A B van Kuilenburg; A H van Gennip; howard mcleod
Dihydropyrimidine dehydrogenase pharmacogenetics in Caucasian subjects.
British journal of clinical pharmacology 1998;46(2):151-6.
1998: X Wei; Guillermo Elizondo; A Sapone; howard mcleod; Hannu Raunio; Pedro Fernandez-Salguero; Frank J Gonzalez
Characterization of the human dihydropyrimidine dehydrogenase gene.
Genomics 1998;51(3):391-400.
1998: H Zaher; Pedro Fernandez-Salguero; John J Letterio; M S Sheikh; Albert J Fornace; Anita B Roberts; Frank J Gonzalez
The involvement of aryl hydrocarbon receptor in the activation of transforming growth factor-beta and apoptosis.
Molecular pharmacology 1998;54(2):313-21.
1998: H Zaher; TJ Yang; Harry V Gelboin; Pedro Fernandez-Salguero; Frank J Gonzalez
Effect of phenobarbital on hepatic CYP1A1 and CYP1A2 in the Ahr-null mouse.
Biochemical pharmacology 1998;55(2):235-8.
1998: Susan A Ridge; J Sludden; X Wei; A Sapone; O Brown; S Hardy; P Canney; Pedro Fernandez-Salguero; Frank J Gonzalez; Jim Cassidy; howard mcleod
Dihydropyrimidine dehydrogenase pharmacogenetics in patients with colorectal cancer.
British journal of cancer 1998;77(3):497-500.
1997: Pedro Fernandez-Salguero; Jerrold M Ward; J P Sundberg; Frank J Gonzalez
Lesions of aryl-hydrocarbon receptor-deficient mice.
Veterinary pathology 1997;34(6):605-14.
1997: Fausto Andreola; Pedro Fernandez-Salguero; Maria V Chiantore; Martin Petkovich; Frank J Gonzalez; LUIGI DE LUCA
Aryl hydrocarbon receptor knockout mice (AHR-/-) exhibit liver retinoid accumulation and reduced retinoic acid metabolism.
Cancer research 1997;57(14):2835-8.
1997: HS Chittum; H J Baek; Alan M Diamond; Pedro Fernandez-Salguero; F Gonzalez; T Ohama; Dolph L Hatfield; M Kuehn; Byeong Jae Lee
Selenocysteine tRNA[Ser]Sec levels and selenium-dependent glutathione peroxidase activity in mouse embryonic stem cells heterozygous for a targeted mutation in the tRNA[Ser]Sec gene.
Biochemistry 1997;36(28):8634-9.
1997: H Gullstén; José Agúndez; Julio Benitez; Esa Läärä; José M Ladero; M Díaz-Rubio; Pedro Fernandez-Salguero; F Gonzalez; Arja Rautio; Olavi Pelkonen; Hannu Raunio
CYP2A6 gene polymorphism and risk of liver cancer and cirrhosis.
Pharmacogenetics 1997;7(3):247-50.
1997: Pedro Fernandez-Salguero; A Sapone; X Wei; J R Holt; S Jones; Jeffrey R Idle; Frank J Gonzalez
Lack of correlation between phenotype and genotype for the polymorphically expressed dihydropyrimidine dehydrogenase in a family of Pakistani origin.
Pharmacogenetics 1997;7(2):161-3.
1997: Susan A Ridge; O Brown; J McMurrough; Pedro Fernandez-Salguero; William Evans; Frank J Gonzalez; howard mcleod
Mutations at codon 974 of the DPYD gene are a rare event.
British journal of cancer 1997;75(2):178-9.
1996: Frank J Gonzalez; Pedro Fernandez-Salguero; Jerrold M Ward
The role of the aryl hydrocarbon receptor in animal development, physiological homeostasis and toxicity of TCDD.
The Journal of toxicological sciences 1996;21(5):273-7.
1996: Pedro Fernandez-Salguero; David M Hilbert; Stuart Rudikoff; Jerrold M Ward; Frank J Gonzalez
Aryl-hydrocarbon receptor-deficient mice are resistant to 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced toxicity.
Toxicology and applied pharmacology 1996;140(1):173-9.
1996: X Wei; howard mcleod; J McMurrough; Frank J Gonzalez; Pedro Fernandez-Salguero
Molecular basis of the human dihydropyrimidine dehydrogenase deficiency and 5-fluorouracil toxicity.
The Journal of clinical investigation 1996;98(3):610-5.
1996: S S Lee; Jeroen Buters; Thierry Pineau; Pedro Fernandez-Salguero; Frank J Gonzalez
Role of CYP2E1 in the hepatotoxicity of acetaminophen.
The Journal of biological chemistry 1996;271(20):12063-7.
1996: Pedro Fernandez-Salguero; Frank J Gonzalez
Targeted disruption of specific cytochromes P450 and xenobiotic receptor genes.
Methods in enzymology 1996;272():412-30.
1996: S Kimura; Y Hara; Thierry Pineau; Pedro Fernandez-Salguero; C H Fox; J M Ward; F J Gonzalez
The T/ebp null mouse: thyroid-specific enhancer-binding protein is essential for the organogenesis of the thyroid, lung, ventral forebrain, and pituitary.
Genes & development 1996;10(1):60-9.
1995: H Furuya; Pedro Fernandez-Salguero; W Gregory; H Taber; A Steward; Frank J Gonzalez; Jeffrey Idle
Genetic polymorphism of CYP2C9 and its effect on warfarin maintenance dose requirement in patients undergoing anticoagulation therapy.
Pharmacogenetics 1995;5(6):389-92.
1995: Frank J Gonzalez; Pedro Fernandez-Salguero; S S Lee; Thierry Pineau; Jerrold M Ward
Xenobiotic receptor knockout mice.
Toxicology letters 1995;82-83():117-21.
1995: S M Hoffman; Pedro Fernandez-Salguero; F J Gonzalez; Harvey W Mohrenweiser
Organization and evolution of the cytochrome P450 CYP2A-2B-2F subfamily gene cluster on human chromosome 19.
Journal of molecular evolution 1995;41(6):894-900.
1995: Frank J Gonzalez; Pedro Fernandez-Salguero
Diagnostic analysis, clinical importance and molecular basis of dihydropyrimidine dehydrogenase deficiency.
Trends in pharmacological sciences 1995;16(10):325-7.
1995: Pedro Fernandez-Salguero; Frank J Gonzalez; M C Etienne; G Milano; S Kimura
Correlation between catalytic activity and protein content for the polymorphically expressed dihydropyrimidine dehydrogenase in human lymphocytes.
Biochemical pharmacology 1995;50(7):1015-20.
1995: Pedro Fernandez-Salguero; S M Hoffman; S Cholerton; Harvey W Mohrenweiser; H Raunio; Arja Rautio; Olavi Pelkonen; J D Huang; William Evans; Jeffrey Idle
A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 alleles.
American journal of human genetics 1995;57(3):651-60.
1995: C L Crespi; D T Steimel; Bruce W Penman; Kenneth R Korzekwa; Pedro Fernandez-Salguero; Jeroen Buters; H V Gelboin; F J Gonzalez; Jeffrey Idle; Ann K Daly
Comparison of substrate metabolism by wild type CYP2D6 protein and a variant containing methionine, not valine, at position 374.
Pharmacogenetics 1995;5(4):234-43.
1995: S S Lee; Thierry Pineau; J Drago; E J Lee; J W Owens; Deanna L Kroetz; Pedro Fernandez-Salguero; Heiner Westphal; Frank J Gonzalez
Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators.
Molecular and cellular biology 1995;15(6):3012-22.
1995: Thierry Pineau; Pedro Fernandez-Salguero; S S Lee; T McPhail; Jerrold M Ward; Frank J Gonzalez
Neonatal lethality associated with respiratory distress in mice lacking cytochrome P450 1A2.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(11):5134-8.
1995: Pedro Fernandez-Salguero; Thierry Pineau; David M Hilbert; T McPhail; S S Lee; Shioko Kimura; Daniel W Nebert; Stuart Rudikoff; Jerrold M Ward; Frank J Gonzalez
Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah receptor.
Science (New York, N.Y.) 1995;268(5211):722-6.
1995: Rutger Meinsma; Pedro Fernandez-Salguero; André B P van Kuilenburg; Albert H van Gennip; Frank J Gonzalez
Human polymorphism in drug metabolism: mutation in the dihydropyrimidine dehydrogenase gene results in exon skipping and thymine uracilurea.
DNA and cell biology 1995;14(1):1-6.
1995: Pedro Fernandez-Salguero; Frank J Gonzalez
The CYP2A gene subfamily: species differences, regulation, catalytic activities and role in chemical carcinogenesis.
Pharmacogenetics 1995;5 Spec No():S123-8.
1994: H Yokota; Pedro Fernandez-Salguero; H Furuya; K Lin; O W McBride; B Podschun; Klaus D Schnackerz; Frank J Gonzalez
cDNA cloning and chromosome mapping of human dihydropyrimidine dehydrogenase, an enzyme associated with 5-fluorouracil toxicity and congenital thymine uraciluria.
The Journal of biological chemistry 1994;269(37):23192-6.