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Napoleone Ferrara

Research Profile

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Vernon T Phan; Amy Sambrone; Rebecca X Sheng; Qinghua Song; Martha Tan; Christopher Tran; Xiumin Wu; Guanglei Zhuang; Erica L Jackson; Melissa R Junttila; Marcin Kowanetz; Y Gloria Meng; Franklin Peale; Jason H Cheng; Alicia S Chung; Napoleone Ferrara
Oncogenic RAS pathway activation promotes resistance to anti-VEGF therapy through G-CSF-induced neutrophil recruitment.
James A Stefater; Roberto F Nicosia; Jeffrey W Pollard; Sujata Rao; Alfred C Aplin; Katie Bezold; Napoleone Ferrara; Richard A Lang
Macrophage Wnt-Calcineurin-Flt1 signaling regulates mouse wound angiogenesis and repair.
Sujata Rao; Michael B Yang; Christina Chun; David R Copenhagen; Jieqing Fan; Napoleone Ferrara; Rashmi S Hegde; J Matthew Kofron; Richard A Lang
A direct and melanopsin-dependent fetal light response regulates mouse eye development.

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2013: Vernon T Phan; Amy Sambrone; Rebecca X Sheng; Qinghua Song; Martha Tan; Christopher Tran; Xiumin Wu; Guanglei Zhuang; Erica L Jackson; Melissa R Junttila; Marcin Kowanetz; Y Gloria Meng; Franklin Peale; Jason H Cheng; Alicia S Chung; Napoleone Ferrara
Oncogenic RAS pathway activation promotes resistance to anti-VEGF therapy through G-CSF-induced neutrophil recruitment.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(15):6079-84.
2013: James A Stefater; Roberto F Nicosia; Jeffrey W Pollard; Sujata Rao; Alfred C Aplin; Katie Bezold; Napoleone Ferrara; Richard A Lang
Macrophage Wnt-Calcineurin-Flt1 signaling regulates mouse wound angiogenesis and repair.
Blood 2013;121(13):2574-8.
2013: Sujata Rao; Michael B Yang; Christina Chun; David R Copenhagen; Jieqing Fan; Napoleone Ferrara; Rashmi S Hegde; J Matthew Kofron; Richard A Lang
A direct and melanopsin-dependent fetal light response regulates mouse eye development.
Nature 2013;494(7436):243-6.
2013: Guanglei Zhuang; Carlos Bais; Elizabeth Blackwood; Alicia Chung; Connie Ha; Benjamin Haley; Zhaoshi Jiang; Jennie R Lill; Deepak Sampath; Robert Soriano; Karen Toy; Jenny Yao; Kebing Yu; Napoleone Ferrara
Phosphoproteomic Analysis Implicates the mTORC2-FoxO1 Axis in VEGF Signaling and Feedback Activation of Receptor Tyrosine Kinases.
Science signaling 2013;6(271):ra25.
2013: Joan W Miller; Erich C Strauss; Jennifer Le Couter; Napoleone Ferrara
Vascular endothelial growth factor a in intraocular vascular disease.
Ophthalmology 2013;120(1):106-14.
2012: Jing Jin; Nina Jones; Dontscho Kerjaschki; Chengjin Li; Andras Nagy; Tony Pawson; I George Fantus; Napoleone Ferrara; Hans-Peter Gerber; Marie Jeansson; Masabumi Shibuya; Karen Sison; Hoon-Ki Sung; Ruijun Tian; Monika Tucholska; Monika Wnuk; Cunjie Zhang; Susan E Quaggin
Soluble FLT1 binds lipid microdomains in podocytes to control cell morphology and glomerular barrier function.
Cell 2012;151(2):384-99.
2012: Adi Ben Shoham; Yona Ely; Napoleone Ferrara; Sharon Krief; Guy Malkinson; Yulia Shwartz; Karina Yaniv; Elazar Zelzer
S1P1 inhibits sprouting angiogenesis during vascular development.
Development (Cambridge, England) 2012;139(20):3859-69.
2012: Yanqiu Liu; Sutada Lotinun; Roland Baron; Agnes D Berendsen; Napoleone Ferrara; Shidong Jia; Bjorn R Olsen
Intracellular VEGF regulates the balance between osteoblast and adipocyte differentiation.
The Journal of clinical investigation 2012;122(9):3101-13.
2012: Napoleone Ferrara; William J Henzel
Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. 1989.
Biochemical and biophysical research communications 2012;425(3):540-7.
2012: Guanglei Zhuang; Carlos Bais; Yinghui Guan; Zhaoshi Jiang; Ian Kasman; Zora Modrusan; Jason Oeh; Deepak Sampath; Xiumin Wu; Jenny Yao; Napoleone Ferrara
Tumour-secreted miR-9 promotes endothelial cell migration and angiogenesis by activating the JAK-STAT pathway.
The EMBO journal 2012;31(17):3513-23.
2012: Mallika Singh; Kai H Barck; Tim C Cao; Richard A D Carano; Jason H Cheng; Suzana S Couto; Jeffrey Eastham-Anderson; Napoleone Ferrara; Oded Foreman; William F Forrest; Patricia Hamilton; Calvin C K Ho; Adrian M Jubb; Ian Kasman; Anthony Lima; Jason E Long; Angela McNutt; Rafael Molina; Michelle A Nannini; Hani Bou Reslan; Leisa Johnson
Anti-VEGF antibody therapy does not promote metastasis in genetically engineered mouse tumour models.
The Journal of pathology 2012;227(4):417-30.
2012: Alicia S Chung; David Finkle; Laszlo Komuves; Marcin Kowanetz; Hai Ngu; Franklin Peale; Xiumin Wu; Guanglei Zhuang; Napoleone Ferrara
Differential drug class-specific metastatic effects following treatment with a panel of angiogenesis inhibitors.
The Journal of pathology 2012;227(4):404-16.
2012: Sebastian Willenborg; Bent Brachvogel; Napoleone Ferrara; Ingo Haase; Matthias Hammerschmidt; Johanna A Knipper; Thomas Krieg; Tina Lucas; Andras Nagy; Manolis Pasparakis; Geert Van Loo; Sabine A Eming
CCR2 recruits an inflammatory macrophage subpopulation critical for angiogenesis in tissue repair.
Blood 2012;120(3):613-25.
2012: Azeb Tadesse Argaw; Linnea Asp; Dipankar J Dutta; Napoleone Ferrara; Elisabeth G Kramer; Sean Mahase; John N Mariani; Kristina Navrazhina; Trinh Pham; Jeremy Seto; Michael V Sofroniew; Jingya Zhang; Gareth R John
Astrocyte-derived VEGF-A drives blood-brain barrier disruption in CNS inflammatory disease.
The Journal of clinical investigation 2012;122(7):2454-68.
2012: Mallika Singh; Napoleone Ferrara
Modeling and predicting clinical efficacy for drugs targeting the tumor milieu.
Nature biotechnology 2012;30(7):648-57.
2012: Xueping Qu; Lanlan Yu; Guanglei Zhuang; Gloria Meng; Napoleone Ferrara
Induction of Bv8 expression by granulocyte colony-stimulating factor in CD11b+Gr1+ cells: key role of Stat3 signaling.
The Journal of biological chemistry 2012;287(23):19574-84.
2011: Michal Milgrom-Hoffman; Sylvia M Evans; Napoleone Ferrara; Zachary Harrelson; Elazar Zelzer; Eldad Tzahor
The heart endocardium is derived from vascular endothelial progenitors.
Development (Cambridge, England) 2011;138(21):4777-87.
2011: Jenny Yao; Guanglei Zhuang; Napoleone Ferrara; Ian Kasman; Vernon Phan; Masabumi Shibuya; Tobias Vogt; Xiumin Wu; Carlos Bais
Expression of a functional VEGFR-1 in tumor cells is a major determinant of anti-PlGF antibodies efficacy.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(28):11590-5.
2011: James A Stefater; Bart Williams; MARSHA WILLS-KARP; Terry Yamaguchi; Rieko Ajima; Adam R Burr; April C Carpenter; Jieqing Fan; Napoleone Ferrara; Holger Gerhardt; Ian Lewkowich; Giovanni Mariggi; Jeffery D Molkentin; Jeffrey W Pollard; Sujata Rao; Richard Lang
Regulation of angiogenesis by a non-canonical Wnt-Flt1 pathway in myeloid cells.
Nature 2011;474(7352):511-5.
2011: Lanlan Yu; Xiao Huan Liang; Napoleone Ferrara
Comparing protein VEGF inhibitors: In vitro biological studies.
Biochemical and biophysical research communications 2011;408(2):276-81.
2011: Claire E Lewis; Napoleone Ferrara
Multiple effects of angiopoietin-2 blockade on tumors.
Cancer cell 2011;19(4):431-3.
2011: Alicia S Chung; Napoleone Ferrara
Developmental and pathological angiogenesis.
Annual review of cell and developmental biology 2011;27():563-84.
2010: Marcin Kowanetz; Xiumin Wu; John Lee; Martha Tan; Thijs Hagenbeek; Xueping Qu; Lanlan Yu; Jed Ross; Nina Korsisaari; Tim Cao; Hani Bou-Reslan; Dara Kallop; Robby Weimer; Mary J C Ludlam; Joshua S Kaminker; Zora Modrusan; Nicholas van Bruggen; Franklin V Peale; Richard Carano; Y Gloria Meng; Napoleone Ferrara
Granulocyte-colony stimulating factor promotes lung metastasis through mobilization of Ly6G+Ly6C+ granulocytes.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(50):21248-55.
2010: Napoleone Ferrara
Vascular endothelial growth factor and age-related macular degeneration: from basic science to therapy.
Nature medicine 2010;16(10):1107-11.
2010: Benjamin Drogat; Joanna Kalucka; Laura Gutiérrez; Hamida Hammad; Steven Goossens; Morvarid Farhang Ghahremani; Sonia Bartunkova; Katharina Haigh; Kim Deswarte; Omar Nyabi; Michael Naessens; Napoleone Ferrara; Ursula Klingmüller; Bart N Lambrecht; Andras Nagy; Sjaak Philipsen; Jody J Haigh
Vegf regulates embryonic erythroid development through Gata1 modulation.
Blood 2010;116(12):2141-51.
2010: Alicia S Chung; John Lee; Napoleone Ferrara
Targeting the tumour vasculature: insights from physiological angiogenesis.
Nature reviews. Cancer 2010;10(7):505-14.
2010: Napoleone Ferrara
Role of myeloid cells in vascular endothelial growth factor-independent tumor angiogenesis.
Current opinion in hematology 2010;17(3):219-24.
2010: Carlos Bais; Xiumin Wu; Jenny Yao; Suya Yang; Yongping Crawford; Krista McCutcheon; Christine Tan; Ganesh Kolumam; Jean-Michel Vernes; Jeffrey Eastham-Anderson; Peter Haughney; Marcin Kowanetz; Thijs Hagenbeek; Ian Kasman; Hani Bou Reslan; Jed Ross; Nick Van Bruggen; Richard A D Carano; Yu-Ju Gloria Meng; Jo-Anne Hongo; Jean-Philippe Stephan; Masabumi Shibuya; Napoleone Ferrara
PlGF blockade does not inhibit angiogenesis during primary tumor growth.
Cell 2010;141(1):166-77.
2010: Seth B Coffelt; Claire E Lewis; Luigi Naldini; J Martin Brown; Napoleone Ferrara; Michele De Palma
Elusive identities and overlapping phenotypes of proangiogenic myeloid cells in tumors.
The American journal of pathology 2010;176(4):1564-76.
2010: Marco Mura; Matthew Binnie; Bing Han; Chengjin Li; Cristiano Feijó Andrade; Atsushi Shiozaki; Yu Zhang; Napoleone Ferrara; David Hwang; Thomas K Waddell; Shaf Keshavjee; Mingyao Liu
Functions of type II pneumocyte-derived vascular endothelial growth factor in alveolar structure, acute inflammation, and vascular permeability.
The American journal of pathology 2010;176(4):1725-34.
2010: Napoleone Ferrara
Binding to the extracellular matrix and proteolytic processing: two key mechanisms regulating vascular endothelial growth factor action.
Molecular biology of the cell 2010;21(5):687-90.
2010: Nathalie Ortega; Ke Wang; Napoleone Ferrara; Zena Werb; Thiennu H Vu
Complementary interplay between matrix metalloproteinase-9, vascular endothelial growth factor and osteoclast function drives endochondral bone formation.
Disease models & mechanisms 2010;3(3-4):224-35.
2010: Alicia S Chung; Napoleone Ferrara
Targeting the tumor microenvironment with SRC kinase inhibition.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(3):775-7.
2010: Napoleone Ferrara
Pathways mediating VEGF-independent tumor angiogenesis.
Cytokine & growth factor reviews 2010;21(1):21-6.
2010: Beate M Lichtenberger; Poi Kiang Tan; Heide Niederleithner; Napoleone Ferrara; peter petzelbauer; Maria Sibilia
Autocrine VEGF signaling synergizes with EGFR in tumor cells to promote epithelial cancer development.
Cell 2010;140(2):268-79.
2010: Andrew Scott; Michael B Powner; Pranita Gandhi; Claire Clarkin; David H Gutmann; Randall S Johnson; Napoleone Ferrara; Marcus Fruttiger
Astrocyte-derived vascular endothelial growth factor stabilizes vessels in the developing retinal vasculature.
PloS one 2010;5(7):e11863.
2010: Bob Y Liu; Irina Soloviev; Peter Chang; John Lee; XiaoDong Huang; Cuiling Zhong; Napoleone Ferrara; Paul Polakis; Chie Sakanaka
Stromal cell-derived factor-1/CXCL12 contributes to MMTV-Wnt1 tumor growth involving Gr1+CD11b+ cells.
PloS one 2010;5(1):e8611.
2009: Napoleone Ferrara
VEGF-A: a critical regulator of blood vessel growth.
European cytokine network 2009;20(4):158-63.
2009: Yongping Crawford; Napoleone Ferrara
Tumor and stromal pathways mediating refractoriness/resistance to anti-angiogenic therapies.
Trends in pharmacological sciences 2009;30(12):624-30.
2009: James P B O'Connor; Richard A D Carano; Andrew R Clamp; Jed Ross; Calvin C K Ho; Alan Jackson; Geoff J M Parker; Chris Rose; Franklin Peale; Michel Friesenhahn; Claire L Mitchell; Yvonne Watson; Caleb Roberts; Lynn Hope; Sue Cheung; Hani Bou Reslan; Mary Ann T Go; Glenn J Pacheco; Xiumin Wu; Tim C Cao; Sarajane Ross; Giovanni A Buonaccorsi; Karen Davies; Jurjees Hasan; Paula Thornton; Olivia del Puerto; Napoleone Ferrara; Nicholas van Bruggen; Gordon C Jayson
Quantifying antivascular effects of monoclonal antibodies to vascular endothelial growth factor: insights from imaging.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(21):6674-82.
2009: Boris Strilić; Tomás Kucera; Jan Eglinger; Michael R. Hughes; Kelly M McNagny; Sachiko Tsukita; Elisabetta Dejana; Napoleone Ferrara; Eckhard Lammert
The molecular basis of vascular lumen formation in the developing mouse aorta.
Developmental cell 2009;17(4):505-15.
2009: John C Chappell; Sarah M Taylor; Napoleone Ferrara; Victoria L Bautch
Local guidance of emerging vessel sprouts requires soluble Flt-1.
Developmental cell 2009;17(3):377-86.
2009: Napoleone Ferrara
Vascular endothelial growth factor.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(6):789-91.
2009: Farbod Shojaei; Xiumin Wu; Xueping Qu; Marcin Kowanetz; Lanlan Yu; Martha Tan; Y Gloria Meng; Napoleone Ferrara
G-CSF-initiated myeloid cell mobilization and angiogenesis mediate tumor refractoriness to anti-VEGF therapy in mouse models.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(16):6742-7.
2009: Cuiling Zhong; Xueping Qu; Martha Tan; Y Gloria Meng; Napoleone Ferrara
Characterization and regulation of bv8 in human blood cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(8):2675-84.
2009: Idit Eshkar-Oren; Sergey V Viukov; Sharbel Salameh; Sharon Krief; Chun-Do Oh; Haruhiko Akiyama; Hans-Peter Gerber; Napoleone Ferrara; Elazar Zelzer
The forming limb skeleton serves as a signaling center for limb vasculature patterning via regulation of Vegf.
Development (Cambridge, England) 2009;136(8):1263-72.
2009: Claudia M Garcia; Ying-Bo Shui; Meera Kamath; Justin DeVillar; Randall S Johnson; Hans-Peter Gerber; Napoleone Ferrara; Michael L Robinson; David C Beebe
The function of VEGF-A in lens development: formation of the hyaloid capillary network and protection against transient nuclear cataracts.
Experimental eye research 2009;88(2):270-6.
2009: Yongping Crawford; Ian Kasman; Lanlan Yu; Cuiling Zhong; Xiumin Wu; Zora Modrusan; Josh Kaminker; Napoleone Ferrara
PDGF-C mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment.
Cancer cell 2009;15(1):21-34.
2009: Yongping Crawford; Napoleone Ferrara
VEGF inhibition: insights from preclinical and clinical studies.
Cell and tissue research 2009;335(1):261-9.
2008: Farbod Shojaei; Napoleone Ferrara
Role of the microenvironment in tumor growth and in refractoriness/resistance to anti-angiogenic therapies.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2008;11(6):219-30.
2008: N Jabs; I Franklin; M B Brenner; J Gromada; Napoleone Ferrara; C B Wollheim; Eckhard Lammert
Reduced insulin secretion and content in VEGF-a deficient mouse pancreatic islets.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 2008;116 Suppl 1():S46-9.
2008: Farbod Shojaei; Cuiling Zhong; Xiumin Wu; Lanlan Yu; Napoleone Ferrara
Role of myeloid cells in tumor angiogenesis and growth.
Trends in cell biology 2008;18(8):372-8.
2008: Farbod Shojaei; Napoleone Ferrara
Refractoriness to antivascular endothelial growth factor treatment: role of myeloid cells.
Cancer research 2008;68(14):5501-4.
2008: Leanne R Berry; Kai H Barck; Mary Ann Go; Jed Ross; Xiumin Wu; Simon P Williams; Alvin Gogineni; Mary J Cole; Nicholas Van Bruggen; Germaine Fuh; Frank Peale; Napoleone Ferrara; Sarajane Ross; Ralph Schwall; Richard A D Carano
Quantification of viable tumor microvascular characteristics by multispectral analysis.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2008;60(1):64-72.
2008: Vera Eremina; J Ashley Jefferson; Jolanta Kowalewska; Howard Hochster; Mark Haas; Joseph Weisstuch; Catherine Richardson; Jeffrey Kopp; golam kabir; Peter H Backx; Hans-Peter Gerber; Napoleone Ferrara; Laura Barisoni; Charles E Alpers; Susan E Quaggin
VEGF inhibition and renal thrombotic microangiopathy.
The New England journal of medicine 2008;358(11):1129-36.
2008: Claudio Campa; Ian Kasman; Weilan Ye; Wyne P Lee; Germaine Fuh; Napoleone Ferrara
Effects of an anti-VEGF-A monoclonal antibody on laser-induced choroidal neovascularization in mice: optimizing methods to quantify vascular changes.
Investigative ophthalmology & visual science 2008;49(3):1178-83.
2008: Farbod Shojaei; Mallika Singh; Jennifer D Thompson; Napoleone Ferrara
Role of Bv8 in neutrophil-dependent angiogenesis in a transgenic model of cancer progression.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(7):2640-5.
2008: Lanlan Yu; Xiumin Wu; Zhiyong Cheng; Chingwei V Lee; Jennifer LeCouter; Claudio Campa; Germaine Fuh; Henry B Lowman; Napoleone Ferrara
Interaction between bevacizumab and murine VEGF-A: a reassessment.
Investigative ophthalmology & visual science 2008;49(2):522-7.
2008: Yongping Crawford; Napoleone Ferrara
Chapter 6. Mouse models to investigate anti-cancer effects of VEGF inhibitors.
Methods in enzymology 2008;445():125-39.
2008: Nina Korsisaari; Jed Ross; Xiumin Wu; Marcin Kowanetz; Navneet Pal; Linda Hall; Jeffrey Eastham-Anderson; William F Forrest; Nicholas van Bruggen; Franklin Peale; Napoleone Ferrara
Blocking vascular endothelial growth factor-A inhibits the growth of pituitary adenomas and lowers serum prolactin level in a mouse model of multiple endocrine neoplasia type 1.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(1):249-58.
2007: Farbod Shojaei; Xiumin Wu; Cuiling Zhong; Lanlan Yu; Xiao Huan Liang; Jenny Yao; Dominique Blanchard; Carlos Bais; Franklin Peale; Nicholas van Bruggen; Calvin Ho; Jed Ross; Martha Tan; Richard A D Carano; Y Gloria Meng; Napoleone Ferrara
Bv8 regulates myeloid-cell-dependent tumour angiogenesis.
Nature 2007;450(7171):825-31.
2007: Farbod Shojaei; Napoleone Ferrara
Antiangiogenic therapy for cancer: an update.
Cancer journal (Sudbury, Mass.) 2007;13(6):345-8.
2007: Sunyoung Lee; Tom T Chen; Chad L Barber; Maria C Jordan; Jared Murdock; Sharina Desai; Napoleone Ferrara; Andras Nagy; Kenneth P Roos; M Luisa Iruela-Arispe
Autocrine VEGF signaling is required for vascular homeostasis.
Cell 2007;130(4):691-703.
2007: Farbod Shojaei; Xiumin Wu; Ajay K Malik; Cuiling Zhong; Megan E Baldwin; Stefanie Schanz; Germaine Fuh; Hans-Peter Gerber; Napoleone Ferrara
Tumor refractoriness to anti-VEGF treatment is mediated by CD11b+Gr1+ myeloid cells.
Nature biotechnology 2007;25(8):911-20.
2007: Hiroaki Yamamoto; Eun Jun Yun; Hans-Peter Gerber; Napoleone Ferrara; Jeffrey A Whitsett; Thiennu H Vu
Epithelial-vascular cross talk mediated by VEGF-A and HGF signaling directs primary septae formation during distal lung morphogenesis.
Developmental biology 2007;308(1):44-53.
2007: Nina Korsisaari; Ian Kasman; William F Forrest; Navneet Pal; Wei Bai; Germaine Fuh; Franklin Peale; Ron Smits; Napoleone Ferrara
Inhibition of VEGF-A prevents the angiogenic switch and results in increased survival of Apc+/min mice.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(25):10625-30.
2007: Kristy Red-Horse; Napoleone Ferrara
Vascular targeting via caveolae.
Nature biotechnology 2007;25(4):431-2.
2007: Farbod Shojaei; Napoleone Ferrara
Antiangiogenesis to treat cancer and intraocular neovascular disorders.
Laboratory investigation; a journal of technical methods and pathology 2007;87(3):227-30.
2007: Hans-Peter Gerber; Xiumin Wu; Lanlan Yu; Christian Wiesmann; Xiao Huan Liang; Chingwei V Lee; Germaine Fuh; Christine Olsson; Lisa A Damico; David Xie; Y Gloria Meng; Johnny Gutierrez; Racquel Corpuz; Bing Li; Linda Hall; Linda Rangell; Ron Ferrando; Henry B Lowman; Franklin Peale; Napoleone Ferrara
Mice expressing a humanized form of VEGF-A may provide insights into the safety and efficacy of anti-VEGF antibodies.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(9):3478-83.
2007: Wei-Ching Liang; Mark S Dennis; Scott Stawicki; Yvan Chanthery; Qi Pan; Yongmei Chen; Charles Eigenbrot; JianPing Yin; Alexander W Koch; Xiumin Wu; Napoleone Ferrara; Anil Bagri; Marc Tessier-Lavigne; Ryan J Watts; Yan Wu
Function blocking antibodies to neuropilin-1 generated from a designed human synthetic antibody phage library.
Journal of molecular biology 2007;366(3):815-29.
2007: Kristy Red-Horse; Yongping Crawford; Farbod Shojaei; Napoleone Ferrara
Endothelium-microenvironment interactions in the developing embryo and in the adult.
Developmental cell 2007;12(2):181-94.
2007: Napoleone Ferrara; Robert D Mass; Claudio Campa; Robert Kim
Targeting VEGF-A to treat cancer and age-related macular degeneration.
Annual review of medicine 2007;58():491-504.
2006: Limin Hu; Napoleone Ferrara; Robert B Jaffe
Paracrine VEGF/VE-cadherin action on ovarian cancer permeability.
Experimental biology and medicine (Maywood, N.J.) 2006;231(10):1646-52.
2006: Napoleone Ferrara; Lisa A Damico; Naveed Shams; Henry B Lowman; Robert Kim
Development of ranibizumab, an anti-vascular endothelial growth factor antigen binding fragment, as therapy for neovascular age-related macular degeneration.
Retina (Philadelphia, Pa.) 2006;26(8):859-70.
2006: Kristy Red-Horse; Napoleone Ferrara
Imaging tumor angiogenesis.
The Journal of clinical investigation 2006;116(10):2585-7.
2006: Marcin Kowanetz; Napoleone Ferrara
Vascular endothelial growth factor signaling pathways: therapeutic perspective.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(17):5018-22.
2006: Max Tejada; Lanlan Yu; Jianying Dong; Kenneth Jung; Gloria Meng; Franklin Peale; Gretchen D Frantz; Linda Hall; XiaoHuan Liang; Hans-Peter Gerber; Napoleone Ferrara
Tumor-driven paracrine platelet-derived growth factor receptor alpha signaling is a key determinant of stromal cell recruitment in a model of human lung carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(9):2676-88.
2006: Ganka Nikolova; Normund Jabs; Irena Konstantinova; Anna Domogatskaya; Karl Tryggvason; Lydia Sorokin; Reinhard Fässler; Guoqiang Gu; Hans-Peter Gerber; Napoleone Ferrara; Douglas A Melton; Eckhard Lammert
The vascular basement membrane: a niche for insulin gene expression and Beta cell proliferation.
Developmental cell 2006;10(3):397-405.
2006: Vera Eremina; Shiying Cui; Hanspeter Gerber; Napoleone Ferrara; Jody J Haigh; Andras Nagy; Masatsugu Ema; Janet Rossant; Serge Jothy; Jeffrey H Miner; Susan E Quaggin
Vascular endothelial growth factor a signaling in the podocyte-endothelial compartment is required for mesangial cell migration and survival.
Journal of the American Society of Nephrology : JASN 2006;17(3):724-35.
2006: Ajay K Malik; Megan E Baldwin; Franklin Peale; Germaine Fuh; Wei-Ching Liang; Henry B Lowman; Gloria Meng; Napoleone Ferrara; Hans-Peter Gerber
Redundant roles of VEGF-B and PlGF during selective VEGF-A blockade in mice.
Blood 2006;107(2):550-7.
2006: Wei-Ching Liang; Xiumin Wu; Franklin Peale; Chingwei V Lee; Y Gloria Meng; Johnny Gutierrez; Ling Fu; Ajay K Malik; Hans-Peter Gerber; Napoleone Ferrara; Germaine Fuh
Cross-species vascular endothelial growth factor (VEGF)-blocking antibodies completely inhibit the growth of human tumor xenografts and measure the contribution of stromal VEGF.
The Journal of biological chemistry 2006;281(2):951-61.
2005: Napoleone Ferrara; Robert S Kerbel
Angiogenesis as a therapeutic target.
Nature 2005;438(7070):967-74.
2005: Giampietro Gasparini; Raffaele Longo; Masakazu Toi; Napoleone Ferrara
Angiogenic inhibitors: a new therapeutic strategy in oncology.
Nature clinical practice. Oncology 2005;2(11):562-77.
2005: Alexander G Marneros; Jie Fan; Yoshihito Yokoyama; Hans Peter Gerber; Napoleone Ferrara; Rosalie K Crouch; Bjorn R Olsen
Vascular endothelial growth factor expression in the retinal pigment epithelium is essential for choriocapillaris development and visual function.
The American journal of pathology 2005;167(5):1451-9.
2005: Napoleone Ferrara; Kenneth J Hillan; William F Novotny
Bevacizumab (Avastin), a humanized anti-VEGF monoclonal antibody for cancer therapy.
Biochemical and biophysical research communications 2005;333(2):328-35.
2005: Liqing Zhao; Ke Wang; Napoleone Ferrara; Thiennu H Vu
Vascular endothelial growth factor co-ordinates proper development of lung epithelium and vasculature.
Mechanisms of development 2005;122(7-8):877-86.
2005: Napoleone Ferrara
Napoleone Ferrara discusses Avastin and the future of anti-angiogenesis therapy. Interview by Ulrike Knies-Bamforth and Christopher Watson.
Drug discovery today 2005;10(8):539-41.
2005: Yoh-suke Mukouyama; Hans-Peter Gerber; Napoleone Ferrara; Chenghua Gu; David J Anderson
Peripheral nerve-derived VEGF promotes arterial differentiation via neuropilin 1-mediated positive feedback.
Development (Cambridge, England) 2005;132(5):941-52.
2005: Hans-Peter Gerber; Napoleone Ferrara
Pharmacology and pharmacodynamics of bevacizumab as monotherapy or in combination with cytotoxic therapy in preclinical studies.
Cancer research 2005;65(3):671-80.
2005: Napoleone Ferrara
VEGF as a therapeutic target in cancer.
Oncology 2005;69 Suppl 3():11-6.
2005: Napoleone Ferrara
The role of VEGF in the regulation of physiological and pathological angiogenesis.
EXS 2005;(94):209-31.
2004: Jennifer LeCouter; Constance Zlot; Max Tejada; Franklin Peale; Napoleone Ferrara
Bv8 and endocrine gland-derived vascular endothelial growth factor stimulate hematopoiesis and hematopoietic cell mobilization.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(48):16813-8.
2004: Nan Tang; Lianchun Wang; Jeffrey Esko; Frank J Giordano; Yan Huang; Hans-Peter Gerber; Napoleone Ferrara; Randall S Johnson
Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis.
Cancer cell 2004;6(5):485-95.
2004: Rohit Khurana; Zhenwu Zhuang; Shalini Bhardwaj; Masahiro Murakami; Ebo De Muinck; Seppo Yla-Herttuala; Napoleone Ferrara; John F Martin; Ian Zachary; Michael Simons
Angiogenesis-dependent and independent phases of intimal hyperplasia.
Circulation 2004;110(16):2436-43.
2004: Napoleone Ferrara
Vascular endothelial growth factor: basic science and clinical progress.
Endocrine reviews 2004;25(4):581-611.
2004: Michel Samson; Franklin Peale; Gretchen D Frantz; Nathalie Rioux-Leclercq; Ewa Rajpert-De Meyts; Napoleone Ferrara
Human endocrine gland-derived vascular endothelial growth factor: expression early in development and in Leydig cell tumors suggests roles in normal and pathological testis angiogenesis.
The Journal of clinical endocrinology and metabolism 2004;89(8):4078-88.
2004: Jianying Dong; Jeremy Grunstein; Max Tejada; Franklin Peale; Gretchen D Frantz; Wei-Ching Liang; Wei Bai; Lanlan Yu; Joe Kowalski; Xiaohuan Liang; Germaine Fuh; Hans-Peter Gerber; Napoleone Ferrara
VEGF-null cells require PDGFR alpha signaling-mediated stromal fibroblast recruitment for tumorigenesis.
The EMBO journal 2004;23(14):2800-10.
2004: Heike E Daldrup-Link; Yoshitaka Okuhata; Allan Wolfe; Sudesk Srivastav; Sven Øie; Napoleone Ferrara; Robert L Cohen; David M Shames; Robert C Brasch
Decrease in tumor apparent permeability-surface area product to a MRI macromolecular contrast medium following angiogenesis inhibition with correlations to cytotoxic drug accumulation.
Microcirculation (New York, N.Y. : 1994) 2004;11(5):387-96.
2004: Boris A Hesser; Xiao Huan Liang; Gieri Camenisch; Suya Yang; David A Lewin; Richard Scheller; Napoleone Ferrara; Hans-Peter Gerber
Down syndrome critical region protein 1 (DSCR1), a novel VEGF target gene that regulates expression of inflammatory markers on activated endothelial cells.
Blood 2004;104(1):149-58.
2004: Herbert I Hurwitz; Louis Fehrenbacher; William F Novotny; Thomas Cartwright; John Hainsworth; William Heim; Jordan Berlin; Ari Baron; Susan Griffing; Eric Holmgren; Napoleone Ferrara; Gwen Fyfe; Beth Rogers; Robert Ross; Fairooz Kabbinavar
Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer.
The New England journal of medicine 2004;350(23):2335-42.
2004: Napoleone Ferrara; Kenneth J Hillan; Hans-Peter Gerber; William F Novotny
Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer.
Nature reviews. Drug discovery 2004;3(5):391-400.
2004: Elazar Zelzer; Roni Mamluk; Napoleone Ferrara; Randall S Johnson; Ernestina Schipani; Bjorn R Olsen
VEGFA is necessary for chondrocyte survival during bone development.
Development (Cambridge, England) 2004;131(9):2161-71.
2004: Jennifer LeCouter; Rui Lin; Napoleone Ferrara
EG-VEGF: a novel mediator of endocrine-specific angiogenesis, endothelial phenotype, and function.
Annals of the New York Academy of Sciences 2004;1014():50-7.
2004: Napoleone Ferrara; Jennifer LeCouter; Rui Lin; Franklin Peale
EG-VEGF and Bv8: a novel family of tissue-restricted angiogenic factors.
Biochimica et biophysica acta 2004;1654(1):69-78.
2004: Sabine Raab; Heike Beck; Andreas Gaumann; Ali Yüce; Hans-Peter Gerber; Karl H Plate; Hans-Peter Hammes; Napoleone Ferrara; Georg Breier
Impaired brain angiogenesis and neuronal apoptosis induced by conditional homozygous inactivation of vascular endothelial growth factor.
Thrombosis and haemostasis 2004;91(3):595-605.
2004: Napoleone Ferrara
Vascular endothelial growth factor as a target for anticancer therapy.
The oncologist 2004;9 Suppl 1():2-10.
2004: Ingela Franck Lissbrant; Peter Hammarsten; Erik Lissbrant; Napoleone Ferrara; Stina Häggström Rudolfsson; Anders Bergh
Neutralizing VEGF bioactivity with a soluble chimeric VEGF-receptor protein flt(1-3)IgG inhibits testosterone-stimulated prostate growth in castrated mice.
The Prostate 2004;58(1):57-65.
2003: Jody J Haigh; Paula I Morelli; Holger Gerhardt; Katharina Haigh; John Tsien; Annette Damert; Lucile Miquerol; Ulrich Muhlner; Rudiger Klein; Napoleone Ferrara; Erwin F Wagner; Christer Betsholtz; Andras Nagy
Cortical and retinal defects caused by dosage-dependent reductions in VEGF-A paracrine signaling.
Developmental biology 2003;262(2):225-41.
2003: Jennifer LeCouter; Napoleone Ferrara
EG-VEGF and Bv8. a novel family of tissue-selective mediators of angiogenesis, endothelial phenotype, and function.
Trends in cardiovascular medicine 2003;13(7):276-82.
2003: Barbara Blouw; Hanqiu Song; Tarik Tihan; Jenel Bosze; Napoleone Ferrara; Hans-Peter Gerber; Randall S Johnson; Gabriele Bergers
The hypoxic response of tumors is dependent on their microenvironment.
Cancer cell 2003;4(2):133-46.
2003: Eckhard Lammert; Guqiang Gu; Margaret McLaughlin; Dennis Brown; Rolf Brekken; Lewis C. Murtaugh; Hans Peter Gerber; Napoleone Ferrara; Douglas A Melton
Role of VEGF-A in vascularization of pancreatic islets.
Current biology : CB 2003;13(12):1070-4.
2003: Napoleone Ferrara; Hans-Peter Gerber; Jennifer LeCouter
The biology of VEGF and its receptors.
Nature medicine 2003;9(6):669-76.
2003: Napoleone Ferrara; Gretchen D Frantz; Jennifer LeCouter; Lisa Dillard-Telm; Thinh Pham; Aparna Draksharapu; Thomas J Giordano; Franklin Peale
Differential expression of the angiogenic factor genes vascular endothelial growth factor (VEGF) and endocrine gland-derived VEGF in normal and polycystic human ovaries.
The American journal of pathology 2003;162(6):1881-93.
2003: Jennifer LeCouter; Rui Lin; Gretchen D Frantz; Zemin Zhang; Kenneth J Hillan; Napoleone Ferrara
Mouse endocrine gland-derived vascular endothelial growth factor: a distinct expression pattern from its human ortholog suggests different roles as a regulator of organ-specific angiogenesis.
Endocrinology 2003;144(6):2606-16.
2003: Jean-Christophe Tille; Xueyan Wang; Kenneth E Lipson; Gerald McMahon; Napoleone Ferrara; Zhenping Zhu; Daniel J Hicklin; Jonathan P Sleeman; Ulf Eriksson; Kari Alitalo; Michael S Pepper
Vascular endothelial growth factor (VEGF) receptor-2 signaling mediates VEGF-C(deltaNdeltaC)- and VEGF-A-induced angiogenesis in vitro.
Experimental cell research 2003;285(2):286-98.
2003: Thorsten Cramer; Yuji Yamanishi; Björn E Clausen; Irmgard Förster; Rafal Pawlinski; Nigel Mackman; Volker H Haase; Rudolf Jaenisch; Maripat Corr; Victor Nizet; Gary S Firestein; Hans-Peter Gerber; Napoleone Ferrara; Randall S Johnson
HIF-1alpha is essential for myeloid cell-mediated inflammation.
Cell 2003;112(5):645-57.
2003: Jennifer LeCouter; Rui Lin; Max Tejada; Gretchen D Frantz; Franklin Peale; Kenneth J Hillan; Napoleone Ferrara
The endocrine-gland-derived VEGF homologue Bv8 promotes angiogenesis in the testis: Localization of Bv8 receptors to endothelial cells.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(5):2685-90.
2003: Vera Eremina; Manish Sood; Jody J Haigh; Andras Nagy; Ginette Lajoie; Napoleone Ferrara; Hans-Peter Gerber; Yamato Kikkawa; Jeffrey H Miner; Susan E Quaggin
Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases.
The Journal of clinical investigation 2003;111(5):707-16.
2003: Jennifer LeCouter; Dirk R Moritz; Bing Li; Gail Lewis Phillips; Xiao Huan Liang; Hans-Peter Gerber; Kenneth J Hillan; Napoleone Ferrara
Angiogenesis-independent endothelial protection of liver: role of VEGFR-1.
Science (New York, N.Y.) 2003;299(5608):890-3.
2003: Hans-Peter Gerber; Napoleone Ferrara
The role of VEGF in normal and neoplastic hematopoiesis.
Journal of molecular medicine (Berlin, Germany) 2003;81(1):20-31.
2002: Napoleone Ferrara
Role of vascular endothelial growth factor in physiologic and pathologic angiogenesis: therapeutic implications.
Seminars in oncology 2002;29(6 Suppl 16):10-4.
2002: Napoleone Ferrara; Jennifer LeCouter; Rui Lin
Endocrine gland vascular endothelial growth factor (EG-VEGF) and the hypothesis of tissue-specific regulation of angiogenesis.
Endocrine research 2002;28(4):763-4.
2002: Limin Hu; Judith Hofmann; Charles J Zaloudek; Napoleone Ferrara; Thomas Hamilton; Robert B Jaffe
Vascular endothelial growth factor immunoneutralization plus Paclitaxel markedly reduces tumor burden and ascites in athymic mouse model of ovarian cancer.
The American journal of pathology 2002;161(5):1917-24.
2002: Napoleone Ferrara
VEGF and the quest for tumour angiogenesis factors.
Nature reviews. Cancer 2002;2(10):795-803.
2002: Jennifer LeCouter; Rui Lin; Napoleone Ferrara
Endocrine gland-derived VEGF and the emerging hypothesis of organ-specific regulation of angiogenesis.
Nature medicine 2002;8(9):913-7.
2002: John Street; Min Bao; Leo deGuzman; Stuart Bunting; Franklin Peale; Napoleone Ferrara; Hope Steinmetz; John Hoeffel; Jeffrey L Cleland; Ann Daugherty; Nicholas van Bruggen; H Paul Redmond; Richard A D Carano; Ellen H Filvaroff
Vascular endothelial growth factor stimulates bone repair by promoting angiogenesis and bone turnover.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(15):9656-61.
2002: Hans-Peter Gerber; Ajay K Malik; Gregg P Solar; Daniel Sherman; Xiao Huan Liang; Gloria Meng; Kyu Hong; James C Marsters; Napoleone Ferrara
VEGF regulates haematopoietic stem cell survival by an internal autocrine loop mechanism.
Nature 2002;417(6892):954-8.
2002: Gieri Camenisch; Maria Teresa Pisabarro; Daniel Sherman; Joe Kowalski; Mark Nagel; Philip E Hass; Ming-Hong Xie; Austin Gurney; Sarah Bodary; Xiao Huan Liang; Kevin Clark; Maureen H Beresini; Napoleone Ferrara; Hans-Peter Gerber
ANGPTL3 stimulates endothelial cell adhesion and migration via integrin alpha vbeta 3 and induces blood vessel formation in vivo.
The Journal of biological chemistry 2002;277(19):17281-90.
2002: Rui Lin; Jennifer LeCouter; Joe Kowalski; Napoleone Ferrara
Characterization of endocrine gland-derived vascular endothelial growth factor signaling in adrenal cortex capillary endothelial cells.
The Journal of biological chemistry 2002;277(10):8724-9.
2002: Masahiro Inoue; Jeffrey H Hager; Napoleone Ferrara; Hans-Peter Gerber; Douglas Hanahan
VEGF-A has a critical, nonredundant role in angiogenic switching and pancreatic beta cell carcinogenesis.
Cancer cell 2002;1(2):193-202.
2002: Jennifer LeCouter; Napoleone Ferrara
EG-VEGF and the concept of tissue-specific angiogenic growth factors.
Seminars in cell & developmental biology 2002;13(1):3-8.
2002: Jennifer LeCouter; Rui Lin; Napoleone Ferrara
The role of EG-VEGF in the regulation of angiogenesis in endocrine glands.
Cold Spring Harbor symposia on quantitative biology 2002;67():217-21.
2002: Ronald I Clyman; Steven R Seidner; Hiroki Kajino; Christine Roman; Cameron J Koch; Napoleone Ferrara; Nahid Waleh; Françoise Mauray; Yao Qi Chen; Elizabeth Perkett; Timothy Quinn
VEGF regulates remodeling during permanent anatomic closure of the ductus arteriosus.
American journal of physiology. Regulatory, integrative and comparative physiology 2002;282(1):R199-206.
2001: Simon P Williams; Hans-Peter Gerber; Frank J Giordano; Franklin Peale; L J Bernstein; Stuart Bunting; Kenneth R Chien; Napoleone Ferrara; Nicholas van Bruggen
Dobutamine stress cine-MRI of cardiac function in the hearts of adult cardiomyocyte-specific VEGF knockout mice.
Journal of magnetic resonance imaging : JMRI 2001;14(4):374-82.
2001: Jennifer LeCouter; Joe Kowalski; J Foster; Philip E Hass; Zemin Zhang; Lisa Dillard-Telm; Gretchen D Frantz; Linda Rangell; L DeGuzman; Gilbert A Keller; Franklin Peale; Austin Gurney; Kenneth J Hillan; Napoleone Ferrara
Identification of an angiogenic mitogen selective for endocrine gland endothelium.
Nature 2001;412(6850):877-84.
2001: Frank J Giordano; Hans-Peter Gerber; Simon P Williams; N VanBruggen; Stuart Bunting; Pilar Ruiz-Lozano; Y Gu; Anjali K Nath; Yan Huang; Reed Hickey; Nancy Dalton; Kirk L Peterson; John Ross; Kenneth R Chien; Napoleone Ferrara
A cardiac myocyte vascular endothelial growth factor paracrine pathway is required to maintain cardiac function.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(10):5780-5.
2001: X Xin; Suya Yang; Gladys Ingle; Constance Zlot; Linda Rangell; Joe Kowalski; Ralph Schwall; Napoleone Ferrara; Mary E Gerritsen
Hepatocyte growth factor enhances vascular endothelial growth factor-induced angiogenesis in vitro and in vivo.
The American journal of pathology 2001;158(3):1111-20.
2001: H Gille; Joe Kowalski; Bing Li; Jennifer LeCouter; B Moffat; Thomas F Zioncheck; N Pelletier; Napoleone Ferrara
Analysis of biological effects and signaling properties of Flt-1 (VEGFR-1) and KDR (VEGFR-2). A reassessment using novel receptor-specific vascular endothelial growth factor mutants.
The Journal of biological chemistry 2001;276(5):3222-30.
2001: Napoleone Ferrara; Hans-Peter Gerber
The role of vascular endothelial growth factor in angiogenesis.
Acta haematologica 2001;106(4):148-56.
2000: Napoleone Ferrara
VEGF: an update on biological and therapeutic aspects.
Current opinion in biotechnology 2000;11(6):617-24.
2000: Hans-Peter Gerber; Joe Kowalski; Daniel Sherman; David A Eberhard; Napoleone Ferrara
Complete inhibition of rhabdomyosarcoma xenograft growth and neovascularization requires blockade of both tumor and host vascular endothelial growth factor.
Cancer research 2000;60(22):6253-8.
2000: Axel Gossmann; Thomas H Helbich; S Mesiano; David M Shames; Michael F Wendland; Timothy P L Roberts; Napoleone Ferrara; Robert B Jaffe; Robert C Brasch
Magnetic resonance imaging in an experimental model of human ovarian cancer demonstrating altered microvascular permeability after inhibition of vascular endothelial growth factor.
American journal of obstetrics and gynecology 2000;183(4):956-63.
2000: C G Lee; M Heijn; Emmanuelle di Tomaso; G Griffon-Etienne; Marek Ancukiewicz; Chieko Koike; K R Park; Napoleone Ferrara; Rakesh K Jain; Herman D Suit; Yves Boucher
Anti-Vascular endothelial growth factor treatment augments tumor radiation response under normoxic or hypoxic conditions.
Cancer research 2000;60(19):5565-70.
2000: H Gille; Joe Kowalski; L Yu; H Chen; Maria Teresa Pisabarro; T Davis-Smyth; Napoleone Ferrara
A repressor sequence in the juxtamembrane domain of Flt-1 (VEGFR-1) constitutively inhibits vascular endothelial growth factor-dependent phosphatidylinositol 3'-kinase activation and endothelial cell migration.
The EMBO journal 2000;19(15):4064-73.
2000: Hans-Peter Gerber; Napoleone Ferrara
Angiogenesis and bone growth.
Trends in cardiovascular medicine 2000;10(5):223-8.
2000: Gabriel Helmlinger; M Endo; Napoleone Ferrara; L Hlatky; Rakesh K Jain
Formation of endothelial cell networks.
Nature 2000;405(6783):139-41.
2000: Jody J Haigh; H P Gerber; Napoleone Ferrara; Erwin F Wagner
Conditional inactivation of VEGF-A in areas of collagen2a1 expression results in embryonic lethality in the heterozygous state.
Development (Cambridge, England) 2000;127(7):1445-53.
2000: Napoleone Ferrara
Vascular endothelial growth factor and the regulation of angiogenesis.
Recent progress in hormone research 2000;55():15-35; discussion 35-6.
1999: Nicholas van Bruggen; Harold Thibodeaux; JT Palmer; Wyne P Lee; L Fu; B Cairns; D Tumas; Robert T Gerlai; Simon P Williams; M van Lookeren Campagne; Napoleone Ferrara
VEGF antagonism reduces edema formation and tissue damage after ischemia/reperfusion injury in the mouse brain.
The Journal of clinical investigation 1999;104(11):1613-20.
1999: Napoleone Ferrara
Role of vascular endothelial growth factor in the regulation of angiogenesis.
Kidney international 1999;56(3):794-814.
1999: Napoleone Ferrara
Molecular and biological properties of vascular endothelial growth factor.
Journal of molecular medicine (Berlin, Germany) 1999;77(7):527-43.
1999: Hans-Peter Gerber; T H Vu; AM Ryan; Joe Kowalski; Z Werb; Napoleone Ferrara
VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation.
Nature medicine 1999;5(6):623-8.
1999: Hans-Peter Gerber; Kenneth J Hillan; AM Ryan; Joe Kowalski; Gilbert A Keller; Linda Rangell; B D Wright; Freddy Radtke; Michel Aguet; Napoleone Ferrara
VEGF is required for growth and survival in neonatal mice.
Development (Cambridge, England) 1999;126(6):1149-59.
1999: Y P Shi; Napoleone Ferrara
Oncogenic ras fails to restore an in vivo tumorigenic phenotype in embryonic stem cells lacking vascular endothelial growth factor (VEGF).
Biochemical and biophysical research communications 1999;254(2):480-3.
1999: Napoleone Ferrara
Vascular endothelial growth factor: molecular and biological aspects.
Current topics in microbiology and immunology 1999;237():1-30.
1998: Hans-Peter Gerber; A McMurtrey; Joe Kowalski; M Yan; BA Keyt; V Dixit; Napoleone Ferrara
Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3'-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation.
The Journal of biological chemistry 1998;273(46):30336-43.
1998: Ben-Quan Shen; DY Lee; Hans-Peter Gerber; BA Keyt; Napoleone Ferrara; Thomas F Zioncheck
Homologous up-regulation of KDR/Flk-1 receptor expression by vascular endothelial growth factor in vitro.
The Journal of biological chemistry 1998;273(45):29979-85.
1998: S Mesiano; Napoleone Ferrara; Robert B Jaffe
Role of vascular endothelial growth factor in ovarian cancer: inhibition of ascites formation by immunoneutralization.
The American journal of pathology 1998;153(4):1249-56.
1998: Hans-Peter Gerber; V Dixit; Napoleone Ferrara
Vascular endothelial growth factor induces expression of the antiapoptotic proteins Bcl-2 and A1 in vascular endothelial cells.
The Journal of biological chemistry 1998;273(21):13313-6.
1998: Jan L Shifren; S Mesiano; Robert N Taylor; Napoleone Ferrara; Robert B Jaffe
Corticotropin regulates vascular endothelial growth factor expression in human fetal adrenal cortical cells.
The Journal of clinical endocrinology and metabolism 1998;83(4):1342-7.
1998: Napoleone Ferrara; H Chen; T Davis-Smyth; Hans-Peter Gerber; T N Nguyen; DH Peers; V Chisholm; Kenneth J Hillan; Ralph Schwall
Vascular endothelial growth factor is essential for corpus luteum angiogenesis.
Nature medicine 1998;4(3):336-40.
1998: T Davis-Smyth; L G Presta; Napoleone Ferrara
Mapping the charged residues in the second immunoglobulin-like domain of the vascular endothelial growth factor/placenta growth factor receptor Flt-1 required for binding and structural stability.
The Journal of biological chemistry 1998;273(6):3216-22.
1998: CD Pham; Timothy P L Roberts; Nicholas van Bruggen; O Melnyk; J Mann; Napoleone Ferrara; Robert L Cohen; Robert C Brasch
Magnetic resonance imaging detects suppression of tumor vascular permeability after administration of antibody to vascular endothelial growth factor.
Cancer investigation 1998;16(4):225-30.
1998: Renhui Yang; Stuart Bunting; A Ko; BA Keyt; NB Modi; Thomas F Zioncheck; Napoleone Ferrara; Hongkui Jin
Substantially attenuated hemodynamic responses to Escherichia coli-derived vascular endothelial growth factor given by intravenous infusion compared with bolus injection.
The Journal of pharmacology and experimental therapeutics 1998;284(1):103-10.
1997: Leonard G Presta; H Chen; SJ O'Connor; V Chisholm; Y Gloria Meng; L Krummen; M Winkler; Napoleone Ferrara
Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders.
Cancer research 1997;57(20):4593-9.
1997: Hans-Peter Gerber; Fabrizio Condorelli; J Park; Napoleone Ferrara
Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes. Flt-1, but not Flk-1/KDR, is up-regulated by hypoxia.
The Journal of biological chemistry 1997;272(38):23659-67.
1997: Napoleone Ferrara; T Davis-Smyth
The biology of vascular endothelial growth factor.
Endocrine reviews 1997;18(1):4-25.
1997: Napoleone Ferrara; BA Keyt
Vascular endothelial growth factor: basic biology and clinical implications.
EXS 1997;79():209-32.
1996: Hans W Christinger; Yves A Muller; L T Berleau; BA Keyt; BC Cunningham; Napoleone Ferrara; Abraham M de Vos
Crystallization of the receptor binding domain of vascular endothelial growth factor.
Proteins 1996;26(3):353-7.
1996: S Takeshita; L Weir; D Chen; L P Zheng; R Riessen; C Bauters; James Symes; Napoleone Ferrara; Jeffrey M Isner
Therapeutic angiogenesis following arterial gene transfer of vascular endothelial growth factor in a rabbit model of hindlimb ischemia.
Biochemical and biophysical research communications 1996;227(2):628-35.
1996: S Takeshita; Yukio Tsurumi; T Couffinahl; Takayuki Asahara; C Bauters; James Symes; Napoleone Ferrara; Jeffrey M Isner
Gene transfer of naked DNA encoding for three isoforms of vascular endothelial growth factor stimulates collateral development in vivo.
Laboratory investigation; a journal of technical methods and pathology 1996;75(4):487-501.
1996: T Davis-Smyth; H Chen; J Park; L G Presta; Napoleone Ferrara
The second immunoglobulin-like domain of the VEGF tyrosine kinase receptor Flt-1 determines ligand binding and may initiate a signal transduction cascade.
The EMBO journal 1996;15(18):4919-27.
1996: Napoleone Ferrara
Natural killer cells, adhesion and tumor angiogenesis.
Nature medicine 1996;2(9):971-2.
1996: Jan L Shifren; J F Tseng; Charles J Zaloudek; Isabelle P Ryan; Y G Meng; Napoleone Ferrara; Robert B Jaffe; Robert N Taylor
Ovarian steroid regulation of vascular endothelial growth factor in the human endometrium: implications for angiogenesis during the menstrual cycle and in the pathogenesis of endometriosis.
The Journal of clinical endocrinology and metabolism 1996;81(8):3112-8.
1996: Renhui Yang; Roger Thomas; Stuart Bunting; A Ko; Napoleone Ferrara; BA Keyt; J Ross; Hongkui Jin
Effects of vascular endothelial growth factor on hemodynamics and cardiac performance.
Journal of cardiovascular pharmacology 1996;27(6):838-44.
1996: Napoleone Ferrara; K Carver-Moore; H Chen; M Dowd; L Lu; K Sue O'Shea; Lyn Powell-Braxton; Kenneth J Hillan; M W Moore
Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene.
Nature 1996;380(6573):439-42.
1996: BA Keyt; L T Berleau; H V Nguyen; H Chen; H Heinsohn; R Vandlen; Napoleone Ferrara
The carboxyl-terminal domain (111-165) of vascular endothelial growth factor is critical for its mitogenic potency.
The Journal of biological chemistry 1996;271(13):7788-95.
1996: BA Keyt; H V Nguyen; L T Berleau; C M Duarte; J Park; H Chen; Napoleone Ferrara
Identification of vascular endothelial growth factor determinants for binding KDR and FLT-1 receptors. Generation of receptor-selective VEGF variants by site-directed mutagenesis.
The Journal of biological chemistry 1996;271(10):5638-46.
1996: D H Walter; U Hink; Takayuki Asahara; Eric Van Belle; J Horowitz; Yukio Tsurumi; R Vandlen; H Heinsohn; BA Keyt; Napoleone Ferrara; James Symes; Jeffrey M Isner
The in vivo bioactivity of vascular endothelial growth factor/vascular permeability factor is independent of N-linked glycosylation.
Laboratory investigation; a journal of technical methods and pathology 1996;74(2):546-56.
1996: C E Walder; C J Errett; Stuart Bunting; P Lindquist; J R Ogez; H G Heinsohn; Napoleone Ferrara; Roger Thomas
Vascular endothelial growth factor augments muscle blood flow and function in a rabbit model of chronic hindlimb ischemia.
Journal of cardiovascular pharmacology 1996;27(1):91-8.
1995: S Takeshita; S T Rossow; Marianne Kearney; L P Zheng; C Bauters; S Bunting; Napoleone Ferrara; James Symes; Jeffrey M Isner
Time course of increased cellular proliferation in collateral arteries after administration of vascular endothelial growth factor in a rabbit model of lower limb vascular insufficiency.
The American journal of pathology 1995;147(6):1649-60.
1995: Takayuki Asahara; C Bauters; L P Zheng; S Takeshita; S Bunting; Napoleone Ferrara; James Symes; Jeffrey M Isner
Synergistic effect of vascular endothelial growth factor and basic fibroblast growth factor on angiogenesis in vivo.
Circulation 1995;92(9 Suppl):II365-71.
1995: C Bauters; Takayuki Asahara; L P Zheng; S Takeshita; S Bunting; Napoleone Ferrara; James Symes; Jeffrey M Isner
Recovery of disturbed endothelium-dependent flow in the collateral-perfused rabbit ischemic hindlimb after administration of vascular endothelial growth factor.
Circulation 1995;91(11):2802-9.
1995: Takayuki Asahara; C Bauters; C Pastore; Marianne Kearney; S Rossow; S Bunting; Napoleone Ferrara; James Symes; Jeffrey M Isner
Local delivery of vascular endothelial growth factor accelerates reendothelialization and attenuates intimal hyperplasia in balloon-injured rat carotid artery.
Circulation 1995;91(11):2793-801.
1995: Napoleone Ferrara; H Heinsohn; C E Walder; Stuart Bunting; Roger Thomas
The regulation of blood vessel growth by vascular endothelial growth factor.
Annals of the New York Academy of Sciences 1995;752():246-56.
1995: C Bauters; Takayuki Asahara; L P Zheng; S Takeshita; S Bunting; Napoleone Ferrara; James Symes; Jeffrey M Isner
Site-specific therapeutic angiogenesis after systemic administration of vascular endothelial growth factor.
Journal of vascular surgery 1995;21(2):314-24; discussion 324-5.
1994: S Takeshita; Lee L Q Pu; L A Stein; Allan D Sniderman; S Bunting; Napoleone Ferrara; Jeffrey M Isner; James Symes
Intramuscular administration of vascular endothelial growth factor induces dose-dependent collateral artery augmentation in a rabbit model of chronic limb ischemia.
Circulation 1994;90(5 Pt 2):II228-34.
1994: J E Park; H H Chen; J Winer; K A Houck; Napoleone Ferrara
Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR.
The Journal of biological chemistry 1994;269(41):25646-54.
1994: C Bauters; Takayuki Asahara; L P Zheng; S Takeshita; S Bunting; Napoleone Ferrara; James Symes; Jeffrey M Isner
Physiological assessment of augmented vascularity induced by VEGF in ischemic rabbit hindlimb.
The American journal of physiology 1994;267(4 Pt 2):H1263-71.
1994: Jan L Shifren; N Doldi; Napoleone Ferrara; S Mesiano; Robert B Jaffe
In the human fetus, vascular endothelial growth factor is expressed in epithelial cells and myocytes, but not vascular endothelium: implications for mode of action.
The Journal of clinical endocrinology and metabolism 1994;79(1):316-22.
1994: S Takeshita; L P Zheng; Edi Brogi; Marianne Kearney; Lee L Q Pu; S Bunting; Napoleone Ferrara; James Symes; Jeffrey M Isner
Therapeutic angiogenesis. A single intraarterial bolus of vascular endothelial growth factor augments revascularization in a rabbit ischemic hind limb model.
The Journal of clinical investigation 1994;93(2):662-70.
1993: J E Park; G A Keller; Napoleone Ferrara
The vascular endothelial growth factor (VEGF) isoforms: differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VEGF.
Molecular biology of the cell 1993;4(12):1317-26.
1993: Napoleone Ferrara
Vascular endothelial growth factor.
Trends in cardiovascular medicine 1993;3(6):244-50.
1993: L B Jakeman; Mark P Armanini; Heidi S Phillips; Napoleone Ferrara
Developmental expression of binding sites and messenger ribonucleic acid for vascular endothelial growth factor suggests a role for this protein in vasculogenesis and angiogenesis.
Endocrinology 1993;133(2):848-59.
1993: K J Kim; B Li; J Winer; Mark P Armanini; N Gillett; Heidi S Phillips; Napoleone Ferrara
Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo.
Nature 1993;362(6423):841-4.
1993: Napoleone Ferrara; J Winer; T Burton; A Rowland; M Siegel; Heidi S Phillips; T Terrell; Gilbert A Keller; A D Levinson
Expression of vascular endothelial growth factor does not promote transformation but confers a growth advantage in vivo to Chinese hamster ovary cells.
The Journal of clinical investigation 1993;91(1):160-70.
1992: K A Houck; D W Leung; A M Rowland; J Winer; Napoleone Ferrara
Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanisms.
The Journal of biological chemistry 1992;267(36):26031-7.
1992: C de Vries; J A Escobedo; H Ueno; K Houck; Napoleone Ferrara; LT Williams
The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor.
Science (New York, N.Y.) 1992;255(5047):989-91.
1992: Napoleone Ferrara; K Houck; L Jakeman; D W Leung
Molecular and biological properties of the vascular endothelial growth factor family of proteins.
Endocrine reviews 1992;13(1):18-32.
1992: Napoleone Ferrara; J Winer; william james Henzel
Pituitary follicular cells secrete an inhibitor of aortic endothelial cell growth: identification as leukemia inhibitory factor.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(2):698-702.
1992: L B Jakeman; J Winer; G L Bennett; C A Altar; Napoleone Ferrara
Binding sites for vascular endothelial growth factor are localized on endothelial cells in adult rat tissues.
The Journal of clinical investigation 1992;89(1):244-53.
1992: K J Kim; B Li; K Houck; J Winer; Napoleone Ferrara
The vascular endothelial growth factor proteins: identification of biologically relevant regions by neutralizing monoclonal antibodies.
Growth factors (Chur, Switzerland) 1992;7(1):53-64.
1991: K A Houck; Napoleone Ferrara; J Winer; G Cachianes; B Li; D W Leung
The vascular endothelial growth factor family: identification of a fourth molecular species and characterization of alternative splicing of RNA.
Molecular endocrinology (Baltimore, Md.) 1991;5(12):1806-14.
1991: Napoleone Ferrara; K A Houck; L B Jakeman; J Winer; D W Leung
The vascular endothelial growth factor family of polypeptides.
Journal of cellular biochemistry 1991;47(3):211-8.
1991: Napoleone Ferrara; C Clapp; R Weiner
The 16K fragment of prolactin specifically inhibits basal or fibroblast growth factor stimulated growth of capillary endothelial cells.
Endocrinology 1991;129(2):896-900.
1991: Napoleone Ferrara; J Winer; T Burton
Aortic smooth muscle cells express and secrete vascular endothelial growth factor.
Growth factors (Chur, Switzerland) 1991;5(2):141-8.
1990: Heidi S Phillips; J Hains; D W Leung; Napoleone Ferrara
Vascular endothelial growth factor is expressed in rat corpus luteum.
Endocrinology 1990;127(2):965-7.
1989: D W Leung; G Cachianes; W J Kuang; D V Goeddel; Napoleone Ferrara
Vascular endothelial growth factor is a secreted angiogenic mitogen.
Science (New York, N.Y.) 1989;246(4935):1306-9.