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Siew-Lan Ang

Research Profile

Living Beings

Mouse

Chemicals & Drugs

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Simon R W Stott; Rene Hen; Klaus H Kaestner; Wei Lin; Emmanouil Metzakopian; Siew-Lan Ang
Foxa1 and foxa2 are required for the maintenance of dopaminergic properties in ventral midbrain neurons at late embryonic stages.
Emmanouil Metzakopian; Thomas Perlmann; Mali Salmon-Divon; Jeffrey A Whitsett; Paul Bertone; Heidi Dvinge; Johan Ericson; Wei Lin; Elisabet Andersson; Siew-Lan Ang
Genome-wide characterization of Foxa2 targets reveals upregulation of floor plate genes and repression of ventrolateral genes in midbrain dopaminergic progenitors.
Carol H Yan; Suzanne Claxton; Randy L Johnson; Martin Levesque; Siew-Lan Ang
Lmx1a and lmx1b function cooperatively to regulate proliferation, specification, and differentiation of midbrain dopaminergic progenitors.

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All Publications

2013: Simon R W Stott; Rene Hen; Klaus H Kaestner; Wei Lin; Emmanouil Metzakopian; Siew-Lan Ang
Foxa1 and foxa2 are required for the maintenance of dopaminergic properties in ventral midbrain neurons at late embryonic stages.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013;33(18):8022-34.
2012: Emmanouil Metzakopian; Thomas Perlmann; Mali Salmon-Divon; Jeffrey A Whitsett; Paul Bertone; Heidi Dvinge; Johan Ericson; Wei Lin; Elisabet Andersson; Siew-Lan Ang
Genome-wide characterization of Foxa2 targets reveals upregulation of floor plate genes and repression of ventrolateral genes in midbrain dopaminergic progenitors.
Development (Cambridge, England) 2012;139(14):2625-34.
2011: Carol H Yan; Suzanne Claxton; Randy L Johnson; Martin Levesque; Siew-Lan Ang
Lmx1a and lmx1b function cooperatively to regulate proliferation, specification, and differentiation of midbrain dopaminergic progenitors.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(35):12413-25.
2011: Michelle Pelling; Neal Anthwal; David McNay; Gérard Gradwohl; Andrew B Leiter; Francois Guillemot; Siew-Lan Ang
Differential requirements for neurogenin 3 in the development of POMC and NPY neurons in the hypothalamus.
Developmental biology 2011;349(2):406-16.
2011: Yannis E Mavromatakis; Wei Lin; Emmanouil Metzakopian; Anna L M Ferri; Carol H Yan; Hiroshi Sasaki; Jeff Whisett; Siew-Lan Ang
Foxa1 and Foxa2 positively and negatively regulate Shh signalling to specify ventral midbrain progenitor identity.
Mechanisms of development 2011;128(1-2):90-103.
2009: Wei Lin; Emmanouil Metzakopian; Yannis E Mavromatakis; Nan Gao; Nikolaos Balaskas; Hiroshi Sasaki; James Briscoe; Jeffrey A Whitsett; Martyn Goulding; Klaus H Kaestner; Siew-Lan Ang
Foxa1 and Foxa2 function both upstream of and cooperatively with Lmx1a and Lmx1b in a feedforward loop promoting mesodiencephalic dopaminergic neuron development.
Developmental biology 2009;333(2):386-96.
2009: Min Yin; Shuxi Liu; Yanqing Yin; Sen Li; Zhihua Li; Xuefei Wu; Bo Zhang; Siew-Lan Ang; Yuqiang Ding; Jiawei Zhou
Ventral mesencephalon-enriched genes that regulate the development of dopaminergic neurons in vivo.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(16):5170-82.
2009: Siew-Lan Ang
Foxa1 and Foxa2 transcription factors regulate differentiation of midbrain dopaminergic neurons.
Advances in experimental medicine and biology 2009;651():58-65.
2007: John Jacob; Anna L M Ferri; Christopher Milton; Fabrice Prin; Patrick Pla; Wei Lin; Anthony Gavalas; Siew-Lan Ang; James Briscoe
Transcriptional repression coordinates the temporal switch from motor to serotonergic neurogenesis.
Nature neuroscience 2007;10(11):1433-9.
2007: Anna L M Ferri; Wei Lin; Yannis E Mavromatakis; Julie C Wang; Hiroshi Sasaki; Jeffrey A Whitsett; Siew-Lan Ang
Foxa1 and Foxa2 regulate multiple phases of midbrain dopaminergic neuron development in a dosage-dependent manner.
Development (Cambridge, England) 2007;134(15):2761-9.
2006: Siew-Lan Ang
Transcriptional control of midbrain dopaminergic neuron development.
Development (Cambridge, England) 2006;133(18):3499-506.
2006: Chen Wang; Caihong Xia; Wei Bian; Li Liu; Wei Lin; Ye-Guang Chen; Siew-Lan Ang; Naihe Jing
Cell aggregation-induced FGF8 elevation is essential for P19 cell neural differentiation.
Molecular biology of the cell 2006;17(7):3075-84.
2006: David E G McNay; Michelle Pelling; Suzanne Claxton; François Guillemot; Siew-Lan Ang
Mash1 is required for generic and subtype differentiation of hypothalamic neuroendocrine cells.
Molecular endocrinology (Baltimore, Md.) 2006;20(7):1623-32.
2006: Eduardo Puelles; Dario Acampora; Robindra Gogoi; Francesca Tuorto; Alessandro Papalia; Francois Guillemot; Siew-Lan Ang; Antonio Simeone
Otx2 controls identity and fate of glutamatergic progenitors of the thalamus by repressing GABAergic differentiation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(22):5955-64.
2006: Stefan Glaser; Julia Schaft; Sandra Lubitz; Kristina Vintersten; Frank van der Hoeven; Katharina R Tufteland; Rein Aasland; Konstantinos Anastassiadis; Siew-Lan Ang; A Francis Stewart
Multiple epigenetic maintenance factors implicated by the loss of Mll2 in mouse development.
Development (Cambridge, England) 2006;133(8):1423-32.
2006: Julianna Kele; Nicolas Simplicio; Anna L M Ferri; Helena Mira; François Guillemot; Ernest Arenas; Siew-Lan Ang
Neurogenin 2 is required for the development of ventral midbrain dopaminergic neurons.
Development (Cambridge, England) 2006;133(3):495-505.
2006: Anders Borgkvist; Eduardo Puelles; Mario Carta; Dario Acampora; Siew-Lan Ang; Wolfgang Wurst; Michel Goiny; Gilberto Fisone; Antonio Simeone; Alessandro Usiello
Altered dopaminergic innervation and amphetamine response in adult Otx2 conditional mutant mice.
Molecular and cellular neurosciences 2006;31(2):293-302.
2005: Bertrand Vernay; Muriel Koch; Flora M Vaccarino; James Briscoe; Antonio Simeone; Ryoichiro Kageyama; Siew-Lan Ang
Otx2 regulates subtype specification and neurogenesis in the midbrain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(19):4856-67.
2005: Huajing Wan; Sharon Dingle; Yan Xu; Valerie Besnard; Klaus kaestner; Siew-Lan Ang; Susan E Wert; Mildred T Stahlman; Jeffrey A Whitsett
Compensatory roles of Foxa1 and Foxa2 during lung morphogenesis.
The Journal of biological chemistry 2005;280(14):13809-16.
2005: Wei Lin; Naihe Jing; M Albert Basson; Andrée Dierich; Jonathan D Licht; Siew-Lan Ang
Synergistic activity of Sef and Sprouty proteins in regulating the expression of Gbx2 in the mid-hindbrain region.
Genesis (New York, N.Y. : 2000) 2005;41(3):110-5.
2004: Huajing Wan; Yan Xu; Machiko Ikegami; Mildred T Stahlman; Klaus kaestner; Siew-Lan Ang; Jeffrey A Whitsett
Foxa2 is required for transition to air breathing at birth.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(40):14449-54.
2004: Siew-Lan Ang; Daniel B Constam
A gene network establishing polarity in the early mouse embryo.
Seminars in cell & developmental biology 2004;15(5):555-61.
2004: Eduardo Puelles; Alessandro Annino; Francesca Tuorto; Alessandro Usiello; Dario Acampora; Thomas Czerny; Claude Brodski; Siew-Lan Ang; Wolfgang Wurst; Antonio Simeone
Otx2 regulates the extent, identity and fate of neuronal progenitor domains in the ventral midbrain.
Development (Cambridge, England) 2004;131(9):2037-48.
2004: Masamichi Yamamoto; Yukio Saijoh; Aitana Perea-Gomez; William Shawlot; Richard R Behringer; Siew-Lan Ang; Hiroshi Hamada; Chikara Meno
Nodal antagonists regulate formation of the anteroposterior axis of the mouse embryo.
Nature 2004;428(6981):387-92.
2004: Sylvain Meloche; Francis D J Vella; Laure Voisin; Siew-Lan Ang; Marc K Saba-El-Leil
Erk2 signaling and early embryo stem cell self-renewal.
Cell cycle (Georgetown, Tex.) 2004;3(3):241-3.
2004: Huajing Wan; Klaus kaestner; Siew-Lan Ang; Machiko Ikegami; Fred D Finkelman; Mildred T Stahlman; Patricia C Fulkerson; Marc E Rothenberg; Jeffrey A Whitsett
Foxa2 regulates alveolarization and goblet cell hyperplasia.
Development (Cambridge, England) 2004;131(4):953-64.
2003: Marc K Saba-El-Leil; Francis D J Vella; Bertrand Vernay; Laure Voisin; Lan Chen; Nathalie Labrecque; Siew-Lan Ang; Sylvain Meloche
An essential function of the mitogen-activated protein kinase Erk2 in mouse trophoblast development.
EMBO reports 2003;4(10):964-8.
2003: Eduardo Puelles; Dario Acampora; Emmanuel Lacroix; Massimo Signore; Alessandro Annino; Francesca Tuorto; Stefania Filosa; Giorgio Corte; Wolfgang Wurst; Siew-Lan Ang; Antonio Simeone
Otx dose-dependent integrated control of antero-posterior and dorso-ventral patterning of midbrain.
Nature neuroscience 2003;6(5):453-60.
2002: Aitana Perea-Gomez; Francis D J Vella; William Shawlot; Mustapha Oulad-Abdelghani; Claire Chazaud; Chikara Meno; Veronique Pfister; Lan Chen; Elizabeth Robertson; Hiroshi Hamada; Richard R Behringer; Siew-Lan Ang
Nodal antagonists in the anterior visceral endoderm prevent the formation of multiple primitive streaks.
Developmental cell 2002;3(5):745-56.
2002: Georg Mellitzer; Marc Hallonet; Lan Chen; Siew-Lan Ang
Spatial and temporal 'knock down' of gene expression by electroporation of double-stranded RNA and morpholinos into early postimplantation mouse embryos.
Mechanisms of development 2002;118(1-2):57-63.
2002: Wei Lin; Maximilian Fürthauer; Bernard Thisse; Christine Thisse; Naihe Jing; Siew-Lan Ang
Cloning of the mouse Sef gene and comparative analysis of its expression with Fgf8 and Spry2 during embryogenesis.
Mechanisms of development 2002;113(2):163-8.
2002: Marc Hallonet; Klaus kaestner; Luis Martin-Parras; Hiroshi Sasaki; Ulrich A K Betz; Siew-Lan Ang
Maintenance of the specification of the anterior definitive endoderm and forebrain depends on the axial mesendoderm: a study using HNF3beta/Foxa2 conditional mutants.
Developmental biology 2002;243(1):20-33.
2002: Maximilian Fürthauer; Wei Lin; Siew-Lan Ang; Bernard Thisse; Christine Thisse
Sef is a feedback-induced antagonist of Ras/MAPK-mediated FGF signalling.
Nature cell biology 2002;4(2):170-4.
2001: W Ye; M Bouchard; D Stone; X Liu; Francis D J Vella; J Lee; H Nakamura; Siew-Lan Ang; M Busslinger; A Rosenthal
Distinct regulators control the expression of the mid-hindbrain organizer signal FGF8.
Nature neuroscience 2001;4(12):1175-81.
2001: Aitana Perea-Gomez; K A Lawson; M Rhinn; Lise Zakin; Philippe Brûlet; Sylvie Mazan; Siew-Lan Ang
Otx2 is required for visceral endoderm movement and for the restriction of posterior signals in the epiblast of the mouse embryo.
Development (Cambridge, England) 2001;128(5):753-65.
2001: Aitana Perea-Gomez; M Rhinn; Siew-Lan Ang
Role of the anterior visceral endoderm in restricting posterior signals in the mouse embryo.
The International journal of developmental biology 2001;45(1):311-20.
1999: A Perea-Gómez; William Shawlot; Hiroshi Sasaki; Richard R Behringer; Siew-Lan Ang
HNF3beta and Lim1 interact in the visceral endoderm to regulate primitive streak formation and anterior-posterior polarity in the mouse embryo.
Development (Cambridge, England) 1999;126(20):4499-511.
1999: M Rhinn; Andrée Dierich; Marianne Le Meur; Siew-Lan Ang
Cell autonomous and non-cell autonomous functions of Otx2 in patterning the rostral brain.
Development (Cambridge, England) 1999;126(19):4295-304.
1998: M Rhinn; Andrée Dierich; William Shawlot; Richard R Behringer; Marianne Le Meur; Siew-Lan Ang
Sequential roles for Otx2 in visceral endoderm and neuroectoderm for forebrain and midbrain induction and specification.
Development (Cambridge, England) 1998;125(5):845-56.
1998: Christine Biben; E Stanley; Louis J Fabri; Surendra Kotecha; M Rhinn; C Drinkwater; M Lah; CC Wang; Andrew D Nash; D Hilton; Siew-Lan Ang; Timothy J Mohun; Richard P Harvey
Murine cerberus homologue mCer-1: a candidate anterior patterning molecule.
Developmental biology 1998;194(2):135-51.
1997: S Filosa; J A Rivera-Pérez; A P Gómez; Anne Gansmuller; Hiroshi Sasaki; Richard R Behringer; Siew-Lan Ang
Goosecoid and HNF-3beta genetically interact to regulate neural tube patterning during mouse embryogenesis.
Development (Cambridge, England) 1997;124(14):2843-54.
1996: Siew-Lan Ang; O Jin; M Rhinn; N Daigle; L Stevenson; Janet Rossant
A targeted mouse Otx2 mutation leads to severe defects in gastrulation and formation of axial mesoderm and to deletion of rostral brain.
Development (Cambridge, England) 1996;122(1):243-52.
1995: Klaus kaestner; A Paula Monaghan; H Kern; Siew-Lan Ang; Sandra Weitz; Peter Lichter; Günther Schütz
The mouse fkh-2 gene. Implications for notochord, foregut, and midbrain regionalization.
The Journal of biological chemistry 1995;270(50):30029-35.
1994: Siew-Lan Ang; Ronald A Conlon; O Jin; Janet Rossant
Positive and negative signals from mesoderm regulate the expression of mouse Otx2 in ectoderm explants.
Development (Cambridge, England) 1994;120(10):2979-89.
1994: Siew-Lan Ang; Janet Rossant
HNF-3 beta is essential for node and notochord formation in mouse development.
Cell 1994;78(4):561-74.
1993: Siew-Lan Ang; A Wierda; D Wong; K A Stevens; S Cascio; Janet Rossant; Kenneth S Zaret
The formation and maintenance of the definitive endoderm lineage in the mouse: involvement of HNF3/forkhead proteins.
Development (Cambridge, England) 1993;119(4):1301-15.
1993: Siew-Lan Ang; Janet Rossant
Anterior mesendoderm induces mouse Engrailed genes in explant cultures.
Development (Cambridge, England) 1993;118(1):139-49.