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Rose Ann Ferre

Research Profile

Living Beings

Rhinovirus

Chemicals & Drugs

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Drug Design

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Physiology

Molecular Mimicry

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Protein Binding

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Publications

TOP 3
M Catherine Johnson; John Kath; Laura Lingardo; Jiangli Yan; Ping Chen; Jacques Ermolieff; Rose Ann Ferre; Samantha Greasley; Qiyue Hu; Gordon Alton
Novel isoquinolone PDK1 inhibitors discovered through fragment-based lead discovery.
William Vernier; Wesley Chong; David Rewolinski; Samantha Greasley; Thomas Pauly; Morena Shaw; Dac Dinh; Rose Ann Ferre; James W Meador; Seiji Nukui; Martha Ornelas; Robert L Paz; Eric Reyner
Thioether benzenesulfonamide inhibitors of carbonic anhydrases II and IV: structure-based drug design, synthesis, and biological evaluation.
Robert A Love; Karen A Maegley; Xiu Yu; Rose Ann Ferre; Laura K Lingardo; Wade Diehl; Hans E Parge; Peter S Dragovich; Shella A Fuhrman
The crystal structure of the RNA-dependent RNA polymerase from human rhinovirus: a dual function target for common cold antiviral therapy.

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All Publications

2011: M Catherine Johnson; John Kath; Laura Lingardo; Jiangli Yan; Ping Chen; Jacques Ermolieff; Rose Ann Ferre; Samantha Greasley; Qiyue Hu; Gordon Alton
Novel isoquinolone PDK1 inhibitors discovered through fragment-based lead discovery.
Journal of computer-aided molecular design 2011;25(7):689-98.
2010: William Vernier; Wesley Chong; David Rewolinski; Samantha Greasley; Thomas Pauly; Morena Shaw; Dac Dinh; Rose Ann Ferre; James W Meador; Seiji Nukui; Martha Ornelas; Robert L Paz; Eric Reyner
Thioether benzenesulfonamide inhibitors of carbonic anhydrases II and IV: structure-based drug design, synthesis, and biological evaluation.
Bioorganic & medicinal chemistry 2010;18(9):3307-19.
2004: Robert A Love; Karen A Maegley; Xiu Yu; Rose Ann Ferre; Laura K Lingardo; Wade Diehl; Hans E Parge; Peter S Dragovich; Shella A Fuhrman
The crystal structure of the RNA-dependent RNA polymerase from human rhinovirus: a dual function target for common cold antiviral therapy.
Structure (London, England : 1993) 2004;12(8):1533-44.
2002: Theodore O Johnson; Ye Hua; Hiep T Luu; Edward L Brown; Fora Chan; Shao Song Chu; Peter S Dragovich; Brian W Eastman; Rose Ann Ferre; Shella A Fuhrman; Thomas F Hendrickson; Fausto C Maldonado; David A Matthews; James W Meador; Amy K Patick; Siegfried H Reich; Donald J Skalitzky; Stephen T Worland; Michelle Yang; Leora S Zalman
Structure-based design of a parallel synthetic array directed toward the discovery of irreversible inhibitors of human rhinovirus 3C protease.
Journal of medicinal chemistry 2002;45(10):2016-23.
2002: Peter S Dragovich; Thomas J Prins; Ru Zhou; Edward L Brown; Fausto C Maldonado; Shella A Fuhrman; Leora S Zalman; Tove tuntland; Caroline A Lee; Amy K Patick; David A Matthews; Thomas F Hendrickson; Maha B Kosa; Bo Liu; Minerva R Batugo; Jean-Paul R Gleeson; Sylvie K Sakata; Lijian Chen; Mark C Guzman; James W Meador; Rose Ann Ferre; Stephen T Worland
Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 6. Structure-activity studies of orally bioavailable, 2-pyridone-containing peptidomimetics.
Journal of medicinal chemistry 2002;45(8):1607-23.
2002: Peter S Dragovich; Thomas J Prins; Ru Zhou; Theodore O Johnson; Edward L Brown; Fausto C Maldonado; Shella A Fuhrman; Leora S Zalman; Amy K Patick; David A Matthews; Xinjun Hou; James W Meador; Rose Ann Ferre; Stephen T Worland
Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. Part 7: structure-activity studies of bicyclic 2-pyridone-containing peptidomimetics.
Bioorganic & medicinal chemistry letters 2002;12(5):733-8.
2001: Stephen E Webber; Joseph T Marakovits; Peter S Dragovich; Thomas J Prins; Ru Zhou; Shella A Fuhrman; Amy K Patick; David A Matthews; Caroline A Lee; B Srinivasan; T Moran; CE Ford; Mary A Brothers; JE Harr; James W Meador; Rose Ann Ferre; Stephen T Worland
Design and synthesis of irreversible depsipeptidyl human rhinovirus 3C protease inhibitors.
Bioorganic & medicinal chemistry letters 2001;11(20):2683-6.
2000: Siegfried H Reich; T Johnson; MB Wallace; S E Kephart; Shella A Fuhrman; Stephen T Worland; David A Matthews; Thomas F Hendrickson; F Chan; James W Meador; Rose Ann Ferre; Edward L Brown; DM DeLisle; Amy K Patick; Susan Binford; CE Ford
Substituted benzamide inhibitors of human rhinovirus 3C protease: structure-based design, synthesis, and biological evaluation.
Journal of medicinal chemistry 2000;43(9):1670-83.
2000: Peter S Dragovich; Ru Zhou; Stephen E Webber; Thomas J Prins; A K Kwok; K Okano; Shella A Fuhrman; Leora S Zalman; Fausto C Maldonado; Edward L Brown; James W Meador; Amy K Patick; CE Ford; Mary A Brothers; Susan Binford; David A Matthews; Rose Ann Ferre; Stephen T Worland
Structure-based design of ketone-containing, tripeptidyl human rhinovirus 3C protease inhibitors.
Bioorganic & medicinal chemistry letters 2000;10(1):45-8.
1999: David A Matthews; Peter S Dragovich; Stephen E Webber; Shella A Fuhrman; Amy K Patick; Leora S Zalman; Thomas F Hendrickson; Robert A Love; Thomas J Prins; Joseph T Marakovits; Ru Zhou; Jayashree G Tikhe; CE Ford; James W Meador; Rose Ann Ferre; Edward L Brown; Susan Binford; Mary A Brothers; DM DeLisle; Stephen T Worland
Structure-assisted design of mechanism-based irreversible inhibitors of human rhinovirus 3C protease with potent antiviral activity against multiple rhinovirus serotypes.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(20):11000-7.
1999: Peter S Dragovich; Stephen E Webber; Thomas J Prins; Ru Zhou; Joseph T Marakovits; Jayashree G Tikhe; Shella A Fuhrman; Amy K Patick; David A Matthews; CE Ford; Edward L Brown; Susan Binford; James W Meador; Rose Ann Ferre; Stephen T Worland
Structure-based design of irreversible, tripeptidyl human rhinovirus 3C protease inhibitors containing N-methyl amino acids.
Bioorganic & medicinal chemistry letters 1999;9(15):2189-94.
1999: Peter S Dragovich; Thomas J Prins; Ru Zhou; Stephen E Webber; Joseph T Marakovits; Shella A Fuhrman; Amy K Patick; David A Matthews; Caroline A Lee; CE Ford; B J Burke; Paul Rejto; Thomas F Hendrickson; Tove tuntland; Edward L Brown; James W Meador; Rose Ann Ferre; JE Harr; Maha B Kosa; Stephen T Worland
Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 4. Incorporation of P1 lactam moieties as L-glutamine replacements.
Journal of medicinal chemistry 1999;42(7):1213-24.
1999: Peter S Dragovich; Thomas J Prins; Ru Zhou; Shella A Fuhrman; Amy K Patick; David A Matthews; CE Ford; James W Meador; Rose Ann Ferre; Stephen T Worland
Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 3. Structure-activity studies of ketomethylene-containing peptidomimetics.
Journal of medicinal chemistry 1999;42(7):1203-12.
1998: Peter S Dragovich; Stephen E Webber; R E Babine; Shella A Fuhrman; Amy K Patick; David A Matthews; Siegfried H Reich; Joseph T Marakovits; Thomas J Prins; Ru Zhou; Jayashree G Tikhe; E S Littlefield; T M Bleckman; MB Wallace; T L Little; CE Ford; James W Meador; Rose Ann Ferre; Edward L Brown; Susan Binford; DM DeLisle; Stephen T Worland
Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 2. Peptide structure-activity studies.
Journal of medicinal chemistry 1998;41(15):2819-34.
1998: Peter S Dragovich; Stephen E Webber; R E Babine; Shella A Fuhrman; Amy K Patick; David A Matthews; Caroline A Lee; Siegfried H Reich; Thomas J Prins; Joseph T Marakovits; E S Littlefield; Ru Zhou; Jayashree G Tikhe; CE Ford; MB Wallace; James W Meador; Rose Ann Ferre; Edward L Brown; Susan Binford; JE Harr; DM DeLisle; Stephen T Worland
Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 1. Michael acceptor structure-activity studies.
Journal of medicinal chemistry 1998;41(15):2806-18.
1998: Stephen E Webber; K Okano; T L Little; Siegfried H Reich; Y Xin; Shella A Fuhrman; David A Matthews; Robert A Love; Thomas F Hendrickson; Amy K Patick; James W Meador; Rose Ann Ferre; Edward L Brown; CE Ford; Susan Binford; Stephen T Worland
Tripeptide aldehyde inhibitors of human rhinovirus 3C protease: design, synthesis, biological evaluation, and cocrystal structure solution of P1 glutamine isosteric replacements.
Journal of medicinal chemistry 1998;41(15):2786-805.
1996: Stephen E Webber; Jayashree G Tikhe; Stephen T Worland; Shella A Fuhrman; Thomas F Hendrickson; David A Matthews; Robert A Love; Amy K Patick; James W Meador; Rose Ann Ferre; Edward L Brown; DM DeLisle; CE Ford; Susan Binford
Design, synthesis, and evaluation of nonpeptidic inhibitors of human rhinovirus 3C protease.
Journal of medicinal chemistry 1996;39(26):5072-82.
1994: David A Matthews; Ward W Smith; Rose Ann Ferre; B Condon; G Budahazi; W Sisson; J Ernest Villafranca; Cheryl A Janson; H E McElroy; C L Gribskov
Structure of human rhinovirus 3C protease reveals a trypsin-like polypeptide fold, RNA-binding site, and means for cleaving precursor polyprotein.
Cell 1994;77(5):761-71.