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Giora Feuerstein

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Alan G Japp; Arie Katz; Ninian N Lang; Xu Meng; David Burt; Raj Chelliah; Thomas M Connolly; Giora Z Feuerstein; Keith A A Fox; Laura Tattersall; Kathleen Weisel; David E Newby
Effect of PSI-697, a novel P-selectin inhibitor, on platelet-monocyte aggregate formation in humans.
Azmi Adawi; Carlo Bisignano; Salvatore Cuzzocrea; Giora Z Feuerstein; Angela Filocamo; Tiziana Genovese; Camellia Khouri-Assi; Anat Neville; Lewis F Neville
In vitro and in vivo properties of a fully human IgG1 monoclonal antibody that combats multidrug resistant Pseudomonas aeruginosa.
Jennifer M J Richards; P Huw Roddie; Scott I K Semple; Catherine A Shaw; A John Simpson; Marc L Turner; William A Wallace; Michelle C Williams; Shirjel R Alam; Anne P M Atkinson; G Robin Barclay; Carol Bienek; Anne Burdess; Thomas A Connolly; Julie H Crawford; Kev Dhaliwal; Giora Z Feuerstein; Elaine K Forrest; Calum Gray; Adam T Hill; Ninian N Lang; Thomas J MacGillivray; Graham McKillop; Nicholas L Mills; David E Newby
In vivo mononuclear cell tracking using superparamagnetic particles of iron oxide: feasibility and safety in humans.

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2013: Alan G Japp; Arie Katz; Ninian N Lang; Xu Meng; David Burt; Raj Chelliah; Thomas M Connolly; Giora Z Feuerstein; Keith A A Fox; Laura Tattersall; Kathleen Weisel; David E Newby
Effect of PSI-697, a novel P-selectin inhibitor, on platelet-monocyte aggregate formation in humans.
Journal of the American Heart Association 2013;2(1):e006007.
2012: Azmi Adawi; Carlo Bisignano; Salvatore Cuzzocrea; Giora Z Feuerstein; Angela Filocamo; Tiziana Genovese; Camellia Khouri-Assi; Anat Neville; Lewis F Neville
In vitro and in vivo properties of a fully human IgG1 monoclonal antibody that combats multidrug resistant Pseudomonas aeruginosa.
International journal of molecular medicine 2012;30(3):455-64.
2012: Jennifer M J Richards; P Huw Roddie; Scott I K Semple; Catherine A Shaw; A John Simpson; Marc L Turner; William A Wallace; Michelle C Williams; Shirjel R Alam; Anne P M Atkinson; G Robin Barclay; Carol Bienek; Anne Burdess; Thomas A Connolly; Julie H Crawford; Kev Dhaliwal; Giora Z Feuerstein; Elaine K Forrest; Calum Gray; Adam T Hill; Ninian N Lang; Thomas J MacGillivray; Graham McKillop; Nicholas L Mills; David E Newby
In vivo mononuclear cell tracking using superparamagnetic particles of iron oxide: feasibility and safety in humans.
Circulation. Cardiovascular imaging 2012;5(4):509-17.
2011: Xinkang Wang; Yutian Zhan; Lei Zhao; Bin-Bing Zhou; Robert T Abraham; John Alvarez; Inder Chaudhary; Giora Z Feuerstein
Multimodal biomarker investigation on efficacy and mechanism of action for the mammalian target of rapamycin inhibitor, temsirolimus, in a preclinical mammary carcinoma OncoMouse model: a translational medicine study in support for early clinical development.
The Journal of pharmacology and experimental therapeutics 2011;339(2):421-9.
2011: Ilia Goltsman; Xinkang Wang; Edward R LaVallie; Elizabeth A Diblasio-Smith; Elena Ovcharenko; Aaron Hoffman; Zaid Abassi; Giora Z Feuerstein; Joseph Winaver
Effects of chronic rosiglitazone treatment on renal handling of salt and water in rats with volume-overload congestive heart failure.
Circulation. Heart failure 2011;4(3):345-54.
2010: Andrew J Lucking; Rajesh Chelliah; Alexander D Trotman; Thomas M Connolly; Giora Z Feuerstein; Keith A Fox; Nicholas A Boon; Juan J Badimon; David E Newby
Characterisation and reproducibility of a human ex vivo model of thrombosis.
Thrombosis research 2010;126(5):431-5.
2010: Lisa Logie; Antonio J Ruiz-Alcaraz; Christopher J Schofield; Harinder S Hundal; Giora Z Feuerstein; Jeffrey D Brady; Daniel Crowther; Anna M Tommasi; Christal E Grierson; Bridget Shepherd; Andrew D Morris; Michael K Hansen; Ewan Pearson; Calum Sutherland
Generation, validation and humanisation of a novel insulin resistant cell model.
Biochemical pharmacology 2010;80(7):1042-9.
2010: Xinkang Wang; Xiaorong Liu; Yutian Zhan; Edward R LaVallie; Liz Diblasio-Smith; Lisa Collins-Racie; William M Mounts; J Lynn Rutkowski; Xin Xu; Ilia Goltsman; Zaid Abassi; Joseph Winaver; Giora Z Feuerstein
Pharmacogenomic, physiological, and biochemical investigations on safety and efficacy biomarkers associated with the peroxisome proliferator-activated receptor-gamma activator rosiglitazone in rodents: a translational medicine investigation.
The Journal of pharmacology and experimental therapeutics 2010;334(3):820-9.
2010: Lei Zhao; Yutian Zhan; J Lynn Rutkowski; Giora Z Feuerstein; Xinkang Wang
Correlation between 2- and 3-dimensional assessment of tumor volume and vascular density by ultrasonography in a transgenic mouse model of mammary carcinoma.
Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine 2010;29(4):587-95.
2010: Elena Ovcharenko; Michael K Hansen; Ilia Goltsman; Niroz Abu-Saleh; Zaid Abassi; Kathryn Walsh; Gino Miele; Giora Z Feuerstein; Joseph Winaver
Peroxisome proliferator-activated receptor alpha and alpha/gamma agonists do not cause impairment in renal function in the rat.
Nephron. Physiology 2010;115(3):p21-30.
2009: Zaid Abassi; Joseph Winaver; Giora Z Feuerstein
The biochemical pharmacology of renin inhibitors: implications for translational medicine in hypertension, diabetic nephropathy and heart failure: expectations and reality.
Biochemical pharmacology 2009;78(8):933-40.
2009: Juan C Chavez; Orest Hurko; Frank C Barone; Giora Z Feuerstein
Pharmacologic interventions for stroke: looking beyond the thrombolysis time window into the penumbra with biomarkers, not a stopwatch.
Stroke; a journal of cerebral circulation 2009;40(10):e558-63.
2009: Hong I Wan; J Steve Jacobsen; J Lynn Rutkowski; Giora Z Feuerstein
Translational medicine lessons from flurizan's failure in Alzheimer's disease (AD) trial: Implication for future drug discovery and development for AD.
Clinical and translational science 2009;2(3):242-7.
2009: Giora Z Feuerstein; Juan Chavez
Translational medicine for stroke drug discovery: the pharmaceutical industry perspective.
Stroke; a journal of cerebral circulation 2009;40(3 Suppl):S121-5.
2009: Margaret M Zaleska; Mary Lynn T Mercado; Juan Chavez; Giora Z Feuerstein; Menelas Pangalos; Andrew Wood
The development of stroke therapeutics: promising mechanisms and translational challenges.
Neuropharmacology 2009;56(2):329-41.
2009: Mark Day; J Lynn Rutkowski; Giora Z Feuerstein
Translational medicine--a paradigm shift in modern drug discovery and development: the role of biomarkers.
Advances in experimental medicine and biology 2009;655():1-12.
2009: Juan C Chavez; Margaret M Zaleska; Xinkang Wang; Andrew Wood; Orest Hurko; Menelas Pangalos; Giora Z Feuerstein
Multimodal magnetic resonance imaging for assessing evolution of ischemic penumbra: a key translational medicine strategy to manage the risk of developing novel therapies for acute ischemic stroke.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2009;29(1):217-9.
2008: Giora Z Feuerstein
Cardiac RAGE in sepsis: call TOLL free for anti-RAGE.
Circulation research 2008;102(10):1153-4.
2008: Grant Sellar; John D Alvarez; Frank Loganzo; Richat Abbas; Fred Immermann; Maha Karnoub; Giora Z Feuerstein; Michael E Burczynski; Christina M Coughlin
Opportunities posed by novel patient selection biomarker approaches in oncology drug development: going beyond the cytotoxics.
Biomarkers in medicine 2008;2(2):147-53.
2008: Xinkang Wang; James Carl Keith; Allan D Struthers; Giora Z Feuerstein
Assessment of arterial stiffness, a translational medicine biomarker system for evaluation of vascular risk.
Cardiovascular therapeutics 2008;26(3):214-23.
2008: Giora Z Feuerstein; Margaret M Zaleska; Michael Krams; Xinkang Wang; Mark Day; Julia L Rutkowski; Seth P Finklestein; Menelas Pangalos; Michael Poole; Gary L Stiles; Robert R Ruffolo; Frank L Walsh
Missing steps in the STAIR case: a Translational Medicine perspective on the development of NXY-059 for treatment of acute ischemic stroke.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2008;28(1):217-9.
2007: Giora Z Feuerstein; Robert R Ruffolo
Discontinued drugs in 2006: cardiovascular drugs translational medicine perspective.
Expert opinion on investigational drugs 2007;16(9):1315-26.
2007: Mohamed A Bayorh; Mohammed F Layas; Garret Mann; Giora Z Feuerstein; Danita _ Eatman- Daniels
The effect of diet on simvastatin and losartan enhancement of endothelial function.
Clinical and experimental hypertension (New York, N.Y. : 1993) 2007;29(5):311-25.
2007: Xinkang Wang; J Lynn Rutkowsky; Giora Z Feuerstein
Imaging and molecular biomarkers of vulnerable atheromatous plaques.
Biomarkers in medicine 2007;1(1):23-35.
2006: Qiang-Yuan Liu; Martha Corjay; Giora Z Feuerstein; Ponnal Nambi
Identification and characterization of triosephosphate isomerase that specifically interacts with the integrin alphaIIb cytoplasmic domain.
Biochemical pharmacology 2006;72(5):551-7.
2006: Robert R Ruffolo; Giora Z Feuerstein
Carvedilol case history: the discovery and development of the first β-blocker for the treatment of congestive heart failure.
Expert opinion on drug discovery 2006;1(1):85-9.
2006: Zinaida S Vexler; Frank R Sharp; Giora Z Feuerstein; Stephen Ashwal; Marianne Thoresen; Jerome Y Yager; Donna M Ferriero
Translational stroke research in the developing brain.
Pediatric neurology 2006;34(6):459-63.
2006: Giora Z Feuerstein; Edward W Lee
Neuropeptide Y and the heart: implication for myocardial infarction and heart failure.
EXS 2006;(95):113-22.
2005: Mohamed A Bayorh; Agaba A Ganafa; Danita _ Eatman- Daniels; Marcus Walton; Giora Z Feuerstein
Simvastatin and losartan enhance nitric oxide and reduce oxidative stress in salt-induced hypertension.
American journal of hypertension 2005;18(11):1496-502.
2005: Shaker A Mousa; Jeffrey M Bozarth; Dietmar Seiffert; Giora Z Feuerstein
Using thrombelastography to determine the efficacy of the platelet glycoprotein IIb/IIIa antagonist, roxifiban, on platelet/fibrin-mediated clot dynamics in humans.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 2005;16(3):165-71.
2005: Xinkang Wang; Q Cheng; Lin Xu; Giora Z Feuerstein; Mei-Yin Hsu; Patricia L Smith; D A Seiffert; William A Schumacher; Martin Ogletree; D Gailani
Effects of factor IX or factor XI deficiency on ferric chloride-induced carotid artery occlusion in mice.
Journal of thrombosis and haemostasis : JTH 2005;3(4):695-702.
2004: Carlos A Guzman; Giora Z Feuerstein
Pharmaceutical biotechnology.
Current opinion in biotechnology 2004;15(6):503-5.
2004: Xinkang Wang; Giora Z Feuerstein; Lin Xu; Hugh Wang; William A Schumacher; Martin Ogletree; Rebecca Taub; James J-W Duan; Carl P Decicco; Rui-Qin Liu
Inhibition of tumor necrosis factor-alpha-converting enzyme by a selective antagonist protects brain from focal ischemic injury in rats.
Molecular pharmacology 2004;65(4):890-6.
2003: Xinkang Wang; Xiang Li; Lin Xu; Yutian Zhan; Shoshanit Yaish-Ohad; Joseph A Erhardt; Frank C Barone; Giora Z Feuerstein
Up-regulation of secretory leukocyte protease inhibitor (SLPI) in the brain after ischemic stroke: adenoviral expression of SLPI protects brain from ischemic injury.
Molecular pharmacology 2003;64(4):833-40.
2003: Adrienne L Racanelli; Sandra K Gibbs; Susan Zondlo; Dietmar A Seiffert; Steven M Friedman; Giora Z Feuerstein
Differential effect of the GPIIb/IIIa antagonist orbofiban on human platelet aggregate formation in vitro.
Thrombosis research 2003;110(2-3):99-105.
2003: Dietmar Seiffert; Beth E Thomas; Jodi D Bradley; Deborah A Munzer; Maureen A Tchinnes; David M Kornhauser; Valerie A Cain; Tsushung Hua; Giora Z Feuerstein; David E Martin; Andrew M Stern
Effects of the glycoprotein IIb/IIIa antagonist Roxifiban on P-selectin expression, fibrinogen binding, and microaggregate formation in a phase I dose-finding study: no evidence for platelet activation during treatment with a glycoprotein IIb/IIIa antagonist.
Platelets 2003;14(3):179-87.
2003: Xinkang Wang; Lin Xu; Hugh Wang; Reinhard Grzanna; Yutian Zhan; Robert M Knabb; Joseph M Luettgen; Tracy A Bozarth; Robert Anthony Galemmo; Pancras C Wong; Roberta Bernard; Hugo Vargas; Michael Chopp; Steven M Friedman; Giora Z Feuerstein
Inhibition of factor Xa reduces ischemic brain damage after thromboembolic stroke in rats.
Stroke; a journal of cerebral circulation 2003;34(2):468-74.
2003: Xinkang Wang; Hugh Wang; Lin Xu; Dennis J Rozanski; Taku Sugawara; Pak H Chan; James M Trzaskos; Giora Z Feuerstein
Significant neuroprotection against ischemic brain injury by inhibition of the MEK1 protein kinase in mice: exploration of potential mechanism associated with apoptosis.
The Journal of pharmacology and experimental therapeutics 2003;304(1):172-8.
2002: Xinkang Wang; Robert dorsam; Adam Lauver; Hugh Wang; Frank A Barbera; Sandra Gibbs; David Varon; Naphtali Savion; Steven M Friedman; Giora Z Feuerstein
Comparative analysis of various platelet glycoprotein IIb/IIIa antagonists on shear-induced platelet activation and adhesion.
The Journal of pharmacology and experimental therapeutics 2002;303(3):1114-20.
2002: Xinkang Wang; Lin Xu; Hugh Wang; Yutian Zhan; Ellen Puré; Giora Z Feuerstein
CD44 deficiency in mice protects brain from cerebral ischemia injury.
Journal of neurochemistry 2002;83(5):1172-9.
2002: Lin Xu; Yutian Zhan; Yibin Wang; Giora Z Feuerstein; Xinkang Wang
Recombinant adenoviral expression of dominant negative IkappaBalpha protects brain from cerebral ischemic injury.
Biochemical and biophysical research communications 2002;299(1):14-7.
2002: Xinkang Wang; Lin Xu; Hugh Wang; Peter Young; Matthias Gaestel; Giora Z Feuerstein
Mitogen-activated protein kinase-activated protein (MAPKAP) kinase 2 deficiency protects brain from ischemic injury in mice.
The Journal of biological chemistry 2002;277(46):43968-72.
2002: Susan Zondlo; Xinkang Wang; Giora Z Feuerstein
Effects of orally active glycoprotein IIb/IIIa antagonists on platelet CD40 ligand (CD154) expression and platelet-heteroaggregate formation.
Thrombosis research 2002;106(1):35-40.
2000: John R Toomey; MN Blackburn; B L Storer; Richard E Valocik; Paul F Koster; Giora Z Feuerstein
Comparing the antithrombotic efficacy of a humanized anti-factor IX(a) monoclonal antibody (SB 249417) to the low molecular weight heparin enoxaparin in a rat model of arterial thrombosis.
Thrombosis research 2000;100(1):73-9.
2000: T M Behr; X Wang; Nambi Aiyar; Robert W Coatney; X Li; Paul F Koster; Christiane E Angermann; Eliot ohlstein; Giora Z Feuerstein; J Winaver
Monocyte chemoattractant protein-1 is upregulated in rats with volume-overload congestive heart failure.
Circulation 2000;102(11):1315-22.
2000: Xinkang Wang; Anne M Romanic; Tian-Li Yue; Giora Z Feuerstein; Eliot ohlstein
Expression of interleukin-1beta, interleukin-1 receptor, and interleukin-1 receptor antagonist mRNA in rat carotid artery after balloon angioplasty.
Biochemical and biophysical research communications 2000;271(1):138-43.
2000: R William Currie; JA Ellison; Ray F White; Giora Z Feuerstein; Xinkang Wang; Frank C Barone
Benign focal ischemic preconditioning induces neuronal Hsp70 and prolonged astrogliosis with expression of Hsp27.
Brain research 2000;863(1-2):169-81.
2000: Tian-Li Yue; C Wang; Juan-li Gu; Xin L Ma; S Kumar; John Lee; Giora Z Feuerstein; H Thomas; B Maleeff; Eliot ohlstein
Inhibition of extracellular signal-regulated kinase enhances Ischemia/Reoxygenation-induced apoptosis in cultured cardiac myocytes and exaggerates reperfusion injury in isolated perfused heart.
Circulation research 2000;86(6):692-9.
2000: Xinkang Wang; X Li; R William Currie; R N Willette; Frank C Barone; Giora Z Feuerstein
Application of real-time polymerase chain reaction to quantitate induced expression of interleukin-1beta mRNA in ischemic brain tolerance.
Journal of neuroscience research 2000;59(2):238-46.
2000: Xinkang Wang; X Li; Joseph A Erhardt; Frank C Barone; Giora Z Feuerstein
Detection of tumor necrosis factor-alpha mRNA induction in ischemic brain tolerance by means of real-time polymerase chain reaction.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2000;20(1):15-20.
1999: Giora Z Feuerstein; John R Toomey; Richard E Valocik; Paul F Koster; A Patel; MN Blackburn
An inhibitory anti-factor IX antibody effectively reduces thrombus formation in a rat model of venous thrombosis.
Thrombosis and haemostasis 1999;82(5):1443-5.
1999: Giora Z Feuerstein; A Patel; John R Toomey; P Bugelski; A J Nichols; W R Church; Richard E Valocik; Paul F Koster; A Baker; MN Blackburn
Antithrombotic efficacy of a novel murine antihuman factor IX antibody in rats.
Arteriosclerosis, thrombosis, and vascular biology 1999;19(10):2554-62.
1999: Xinkang Wang; X Li; Shoshanit Yaish-Ohad; Henry M Sarau; Frank C Barone; Giora Z Feuerstein
Molecular cloning and expression of the rat monocyte chemotactic protein-3 gene: a possible role in stroke.
Brain research. Molecular brain research 1999;71(2):304-12.
1999: Frank C Barone; Giora Z Feuerstein
Inflammatory mediators and stroke: new opportunities for novel therapeutics.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1999;19(8):819-34.
1999: JJ Velier; JA Ellison; KK Kikly; PA Spera; Frank C Barone; Giora Z Feuerstein
Caspase-8 and caspase-3 are expressed by different populations of cortical neurons undergoing delayed cell death after focal stroke in the rat.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(14):5932-41.
1999: Sudeep Chandra; R F White; D Everding; Giora Z Feuerstein; Robert W Coatney; SK Sarkar; Frank C Barone
Use of diffusion-weighted MRI and neurological deficit scores to demonstrate beneficial effects of isradipine in a rat model of focal ischemia.
Pharmacology 1999;58(6):292-9.
1999: Xin L Ma; S Kumar; Feng Gao; CS Louden; Bernard L Lopez; Theodore A Christopher; C Wang; John Lee; Giora Z Feuerstein; Tian-Li Yue
Inhibition of p38 mitogen-activated protein kinase decreases cardiomyocyte apoptosis and improves cardiac function after myocardial ischemia and reperfusion.
Circulation 1999;99(13):1685-91.
1999: Tian-Li Yue; J Ni; Anne M Romanic; Juan-li Gu; P Keller; C Wang; S Kumar; G L Yu; Timothy K Hart; Xinkang Wang; Z Xia; Walter E DeWolf; Giora Z Feuerstein
TL1, a novel tumor necrosis factor-like cytokine, induces apoptosis in endothelial cells. Involvement of activation of stress protein kinases (stress-activated protein kinase and p38 mitogen-activated protein kinase) and caspase-3-like protease.
The Journal of biological chemistry 1999;274(3):1479-86.
1999: JA Ellison; Frank C Barone; Giora Z Feuerstein
Matrix remodeling after stroke. De novo expression of matrix proteins and integrin receptors.
Annals of the New York Academy of Sciences 1999;890():204-22.
1998: Xinkang Wang; Shoshanit Yaish-Ohad; X Li; Frank C Barone; Giora Z Feuerstein
Use of suppression subtractive hybridization strategy for discovery of increased tissue inhibitor of matrix metalloproteinase-1 gene expression in brain ischemic tolerance.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1998;18(11):1173-7.
1998: H Brunvand; G Liu; X L Ma; Tian-Li Yue; RR Ruffolo; Giora Z Feuerstein
SB 211475, a metabolite of carvedilol, reduces infarct size after myocardial ischemic and reperfusion injury in rabbits.
European journal of pharmacology 1998;356(2-3):193-8.
1998: Frank C Barone; Ray F White; PA Spera; J Ellison; R William Currie; Xinkang Wang; Giora Z Feuerstein
Ischemic preconditioning and brain tolerance: temporal histological and functional outcomes, protein synthesis requirement, and interleukin-1 receptor antagonist and early gene expression.
Stroke; a journal of cerebral circulation 1998;29(9):1937-50; discussion 1950-1.
1998: Xinkang Wang; JA Ellison; A L Siren; PG Lysko; Tian-Li Yue; Frank C Barone; A Shatzman; Giora Z Feuerstein
Prolonged expression of interferon-inducible protein-10 in ischemic cortex after permanent occlusion of the middle cerebral artery in rat.
Journal of neurochemistry 1998;71(3):1194-204.
1998: JA Ellison; JJ Velier; PA Spera; Z L Jonak; Xinkang Wang; Frank C Barone; Giora Z Feuerstein
Osteopontin and its integrin receptor alpha(v)beta3 are upregulated during formation of the glial scar after focal stroke.
Stroke; a journal of cerebral circulation 1998;29(8):1698-706; discussion 1707.
1998: PA Spera; JA Ellison; Giora Z Feuerstein; Frank C Barone
IL-10 reduces rat brain injury following focal stroke.
Neuroscience letters 1998;251(3):189-92.
1998: Frank C Barone; Wallace G Campbell; Allen H Nelson; Giora Z Feuerstein
Carvedilol prevents severe hypertensive cardiomyopathy and remodeling.
Journal of hypertension 1998;16(6):871-84.
1998: Xinkang Wang; CS Louden; Tian-Li Yue; JA Ellison; Frank C Barone; HA Solleveld; Giora Z Feuerstein
Delayed expression of osteopontin after focal stroke in the rat.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(6):2075-83.
1998: Tian-Li Yue; Xin L Ma; Juan-li Gu; RR Ruffolo; Giora Z Feuerstein
Carvedilol inhibits activation of stress-activated protein kinase and reduces reperfusion injury in perfused rabbit heart.
European journal of pharmacology 1998;345(1):61-5.
1998: Tian-Li Yue; C Wang; Anne M Romanic; KK Kikly; P Keller; Walter E DeWolf; Timothy K Hart; Heath C Thomas; B Storer; Juan-li Gu; Xinkang Wang; Giora Z Feuerstein
Staurosporine-induced apoptosis in cardiomyocytes: A potential role of caspase-3.
Journal of molecular and cellular cardiology 1998;30(3):495-507.
1998: Tian-Li Yue; Xin L Ma; Xinkang Wang; Anne M Romanic; GL Liu; CS Louden; Juan-li Gu; S Kumar; G Poste; RR Ruffolo; Giora Z Feuerstein
Possible involvement of stress-activated protein kinase signaling pathway and Fas receptor expression in prevention of ischemia/reperfusion-induced cardiomyocyte apoptosis by carvedilol.
Circulation research 1998;82(2):166-74.
1998: RR Ruffolo; Giora Z Feuerstein
Carvedilol: preclinical profile and mechanisms of action in preventing the progression of congestive heart failure.
European heart journal 1998;19 Suppl B():B19-24.
1998: Xinkang Wang; Frank C Barone; Ray F White; Giora Z Feuerstein
Subtractive cloning identifies tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) increased gene expression following focal stroke.
Stroke; a journal of cerebral circulation 1998;29(2):516-20.
1998: RR Ruffolo; Giora Z Feuerstein
Neurohormonal activation, oxygen free radicals, and apoptosis in the pathogenesis of congestive heart failure.
Journal of cardiovascular pharmacology 1998;32 Suppl 1():S22-30.
1998: Stephen Douglas; A J Nichols; Giora Z Feuerstein; John D Elliott; Eliot ohlstein
SB 209670 inhibits the arrhythmogenic actions of endothelin-1 in the anesthetized dog.
Journal of cardiovascular pharmacology 1998;31 Suppl 1():S99-102.
1998: RR Ruffolo; Giora Z Feuerstein; Eliot ohlstein
Recent observations with beta-adrenoceptor blockade. Beneficial effects in hypertension and heart failure.
American journal of hypertension 1998;11(1 Pt 2):9S-14S.
1998: Theodore A Christopher; Bernard L Lopez; Xin L Ma; Giora Z Feuerstein; RR Ruffolo; Tian-Li Yue
Effects of a hydroxylated metabolite of the beta-andrenoreceptor antagonist, carvedilol, on post-ischaemic splachnic tissue injury.
British journal of pharmacology 1998;123(2):292-8.
1997: Giora Z Feuerstein; A Bril; RR Ruffolo
Protective effects of carvedilol in the myocardium.
The American journal of cardiology 1997;80(11A):41L-45L.
1997: Eliot ohlstein; David P Brooks; Giora Z Feuerstein; RR Ruffolo
Inhibition of sympathetic outflow by the angiotensin II receptor antagonist, eprosartan, but not by losartan, valsartan or irbesartan: relationship to differences in prejunctional angiotensin II receptor blockade.
Pharmacology 1997;55(5):244-51.
1997: Giora Z Feuerstein; Xinkang Wang; Frank C Barone
Inflammatory gene expression in cerebral ischemia and trauma. Potential new therapeutic targets.
Annals of the New York Academy of Sciences 1997;825():179-93.
1997: X Wang; Giora Z Feuerstein
The use of mRNA differential display for discovery of novel therapeutic targets in cardiovascular disease.
Cardiovascular research 1997;35(3):414-21.
1997: Giora Z Feuerstein; X Wang
Use of differential display reverse transcription--polymerase chain reaction for discovery of induced adrenomedullin gene expression in focal stroke.
Canadian journal of physiology and pharmacology 1997;75(6):731-4.
1997: Tian-Li Yue; Xinkang Wang; CS Louden; S Gupta; K Pillarisetti; Juan-li Gu; Timothy K Hart; PG Lysko; Giora Z Feuerstein
2-Methoxyestradiol, an endogenous estrogen metabolite, induces apoptosis in endothelial cells and inhibits angiogenesis: possible role for stress-activated protein kinase signaling pathway and Fas expression.
Molecular pharmacology 1997;51(6):951-62.
1997: Frank C Barone; B Arvin; Ray F White; A Miller; Christine L Webb; Robert N Willette; PG Lysko; Giora Z Feuerstein
Tumor necrosis factor-alpha. A mediator of focal ischemic brain injury.
Stroke; a journal of cerebral circulation 1997;28(6):1233-44.
1997: Xin L Ma; Bernard L Lopez; GL Liu; Theodore A Christopher; Feng Gao; Y Guo; Giora Z Feuerstein; RR Ruffolo; Frank C Barone; Tian-Li Yue
Hypercholesterolemia impairs a detoxification mechanism against peroxynitrite and renders the vascular tissue more susceptible to oxidative injury.
Circulation research 1997;80(6):894-901.
1997: Frank C Barone; Giora Z Feuerstein; R P Spera
Calcium channel blockers in cerebral ischaemia.
Expert opinion on investigational drugs 1997;6(5):501-19.
1997: RR Ruffolo; Giora Z Feuerstein
Pharmacology of carvedilol: rationale for use in hypertension, coronary artery disease, and congestive heart failure.
Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy 1997;11 Suppl 1():247-56.
1997: Xinkang Wang; Frank C Barone; N V Aiyar; Giora Z Feuerstein
Interleukin-1 receptor and receptor antagonist gene expression after focal stroke in rats.
Stroke; a journal of cerebral circulation 1997;28(1):155-61; discussion 161-2.
1997: Frank C Barone; Giora Z Feuerstein; Ray F White
Brain cooling during transient focal ischemia provides complete neuroprotection.
Neuroscience and biobehavioral reviews 1997;21(1):31-44.
1996: Frank C Barone; A H Nelson; Eliot ohlstein; Robert N Willette; J E Sealey; J H Laragh; W G Campbell; Giora Z Feuerstein
Chronic carvedilol reduces mortality and renal damage in hypertensive stroke-prone rats.
The Journal of pharmacology and experimental therapeutics 1996;279(2):948-55.
1996: Lewis F Neville; Fizan Abdullah; Mark H Whiteford; P Ovadia; Giora Z Feuerstein; Reuven Rabinovici
Application of differential display to isolate novel genes in interleukin-2-induced adult respiratory distress syndrome.
Annals of the New York Academy of Sciences 1996;796():257-71.
1996: H Y Cheng; C S Randall; W W Holl; P P Constantinides; Tian-Li Yue; Giora Z Feuerstein
Carvedilol-liposome interaction: evidence for strong association with the hydrophobic region of the lipid bilayers.
Biochimica et biophysica acta 1996;1284(1):20-8.
1996: X Wang; Tian-Li Yue; Eliot ohlstein; C P Sung; Giora Z Feuerstein
Interferon-inducible protein-10 involves vascular smooth muscle cell migration, proliferation, and inflammatory response.
The Journal of biological chemistry 1996;271(39):24286-93.
1996: Giora Z Feuerstein
Platelet-activating factor: a case for its role in CNS function and brain injury.
Journal of lipid mediators and cell signalling 1996;14(1-3):109-14.
1996: Giora Z Feuerstein; RR Ruffolo
Carvedilol, a novel vasodilating beta-blocker with the potential for cardiovascular organ protection.
European heart journal 1996;17 Suppl B():24-9.
1996: Xin L Ma; Tian-Li Yue; Bernard L Lopez; F C Barone; Theodore A Christopher; RR Ruffolo; Giora Z Feuerstein
Carvedilol, a new beta adrenoreceptor blocker and free radical scavenger, attenuates myocardial ischemia-reperfusion injury in hypercholesterolemic rabbits.
The Journal of pharmacology and experimental therapeutics 1996;277(1):128-36.
1996: X Wang; Stephen Douglas; CS Louden; L M Vickery-Clark; Giora Z Feuerstein; Eliot ohlstein
Expression of endothelin-1, endothelin-3, endothelin-converting enzyme-1, and endothelin-A and endothelin-B receptor mRNA after angioplasty-induced neointimal formation in the rat.
Circulation research 1996;78(2):322-8.
1996: B Arvin; L F Neville; Frank C Barone; Giora Z Feuerstein
The role of inflammation and cytokines in brain injury.
Neuroscience and biobehavioral reviews 1996;20(3):445-52.
1995: Tian-Li Yue; X Wang; Juan-li Gu; RR Ruffolo; Giora Z Feuerstein
Carvedilol prevents low-density lipoprotein (LDL)-enhanced monocyte adhesion to endothelial cells by inhibition of LDL oxidation.
European journal of pharmacology 1995;294(2-3):585-91.
1995: X Wang; Tian-Li Yue; Frank C Barone; Ray F White; R K Clark; Robert N Willette; Anthony C Sulpizio; Nambi Aiyar; RR Ruffolo; Giora Z Feuerstein
Discovery of adrenomedullin in rat ischemic cortex and evidence for its role in exacerbating focal brain ischemic damage.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(25):11480-4.
1995: Lewis F Neville; Fizan Abdullah; P M McDonnell; Peter Young; Giora Z Feuerstein; Reuven Rabinovici
Mob-1 expression in IL-2-induced ARDS: regulation by TNF-alpha.
The American journal of physiology 1995;269(6 Pt 1):L884-90.
1995: X Wang; Giora Z Feuerstein
Induced expression of adhesion molecules following focal brain ischemia.
Journal of neurotrauma 1995;12(5):825-32.
1995: B Arvin; L F Neville; Frank C Barone; Giora Z Feuerstein
Brain injury and inflammation. A putative role of TNF alpha.
Annals of the New York Academy of Sciences 1995;765():62-71; discussion 98-9.
1995: X Wang; Tian-Li Yue; Frank C Barone; Giora Z Feuerstein
Demonstration of increased endothelial-leukocyte adhesion molecule-1 mRNA expression in rat ischemic cortex.
Stroke; a journal of cerebral circulation 1995;26(9):1665-8; discussion 1668-9.
1995: Bernard L Lopez; Theodore A Christopher; Tian-Li Yue; RR Ruffolo; Giora Z Feuerstein; Xin L Ma
Carvedilol, a new beta-adrenoreceptor blocker antihypertensive drug, protects against free-radical-induced endothelial dysfunction.
Pharmacology 1995;51(3):165-73.
1995: Giora Z Feuerstein; RR Ruffolo
Carvedilol, a novel multiple action antihypertensive agent with antioxidant activity and the potential for myocardial and vascular protection.
European heart journal 1995;16 Suppl F():38-42.
1995: Tian-Li Yue; X Wang; Juan-li Gu; RR Ruffolo; Giora Z Feuerstein
Carvedilol, a new vasodilating beta-adrenoceptor blocker, inhibits oxidation of low-density lipoproteins by vascular smooth muscle cells and prevents leukocyte adhesion to smooth muscle cells.
The Journal of pharmacology and experimental therapeutics 1995;273(3):1442-9.
1995: X Wang; Giora Z Feuerstein; Juan-li Gu; PG Lysko; Tian-Li Yue
Interleukin-1 beta induces expression of adhesion molecules in human vascular smooth muscle cells and enhances adhesion of leukocytes to smooth muscle cells.
Atherosclerosis 1995;115(1):89-98.
1995: Stephen Douglas; M Gellai; M Ezekiel; Giora Z Feuerstein; John D Elliott; Eliot ohlstein
Antihypertensive actions of the novel nonpeptide endothelin receptor antagonist SB 209670.
Hypertension 1995;25(4 Pt 2):818-22.
1995: Theodore A Christopher; Bernard L Lopez; Tian-Li Yue; Giora Z Feuerstein; RR Ruffolo; Xin L Ma
Carvedilol, a new beta-adrenoreceptor blocker, vasodilator and free-radical scavenger, exerts an anti-shock and endothelial protective effect in rat splanchnic ischemia and reperfusion.
The Journal of pharmacology and experimental therapeutics 1995;273(1):64-71.
1995: X Wang; Tian-Li Yue; Frank C Barone; Giora Z Feuerstein
Monocyte chemoattractant protein-1 messenger RNA expression in rat ischemic cortex.
Stroke; a journal of cerebral circulation 1995;26(4):661-5; discussion 665-6.
1995: Giora Z Feuerstein; A J Nichols; Richard E Valocik; R Gagnon; T S Sellars; R C Fears; H Ferres; R R Ruffolo
Cardioprotection and thrombolysis by anistreplase in anesthetized dogs.
Journal of cardiovascular pharmacology 1995;25(4):625-33.
1995: F C Barone; R F White; John D Elliott; Giora Z Feuerstein; Eliot ohlstein
The endothelin receptor antagonist SB 217242 reduces cerebral focal ischemic brain injury.
Journal of cardiovascular pharmacology 1995;26 Suppl 3():S404-7.
1995: X Wang; Stephen Douglas; Giora Z Feuerstein; Eliot ohlstein
Temporal expression of ECE-1, ET-1, ET-3, ETA, and ETB receptor mRNAs after balloon angioplasty in the rat.
Journal of cardiovascular pharmacology 1995;26 Suppl 3():S22-5.
1995: X Wang; T L Yue; Peter Young; Frank C Barone; Giora Z Feuerstein
Expression of interleukin-6, c-fos, and zif268 mRNAs in rat ischemic cortex.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1995;15(1):166-71.
1995: X Wang; T L Yue; Ray F White; Frank C Barone; Giora Z Feuerstein
Transforming growth factor-beta 1 exhibits delayed gene expression following focal cerebral ischemia.
Brain research bulletin 1995;36(6):607-9.
1995: Frank C Barone; L M Hillegass; MN Tzimas; Dulcie B Schmidt; James J Foley; Ray F White; W J Price; Giora Z Feuerstein; R K Clark; Don E Griswold
Time-related changes in myeloperoxidase activity and leukotriene B4 receptor binding reflect leukocyte influx in cerebral focal stroke.
Molecular and chemical neuropathology / sponsored by the International Society for Neurochemistry and the World Federation of Neurology and research groups on neurochemistry and cerebrospinal fluid 1995;24(1):13-30.
1994: X Wang; Giora Z Feuerstein; R K Clark; Tian-Li Yue
Enhanced leucocyte adhesion to interleukin-1 beta stimulated vascular smooth muscle cells is mainly through intercellular adhesion molecule-1.
Cardiovascular research 1994;28(12):1808-14.
1994: Tian-Li Yue; P J McKenna; Eliot ohlstein; M C Farach-Carson; W T Butler; Kyung O Johanson; P McDevitt; Giora Z Feuerstein; JM Stadel
Osteopontin-stimulated vascular smooth muscle cell migration is mediated by beta 3 integrin.
Experimental cell research 1994;214(2):459-64.
1994: X Wang; A L Siren; Y Liu; Tian-Li Yue; Frank C Barone; Giora Z Feuerstein
Upregulation of intercellular adhesion molecule 1 (ICAM-1) on brain microvascular endothelial cells in rat ischemic cortex.
Brain research. Molecular brain research 1994;26(1-2):61-8.
1994: X Wang; Tian-Li Yue; Frank C Barone; Ray F White; R C Gagnon; Giora Z Feuerstein
Concomitant cortical expression of TNF-alpha and IL-1 beta mRNAs follows early response gene expression in transient focal ischemia.
Molecular and chemical neuropathology / sponsored by the International Society for Neurochemistry and the World Federation of Neurology and research groups on neurochemistry and cerebrospinal fluid 1994;23(2-3):103-14.
1994: T Liu; R K Clark; P C McDonnell; Peter Young; Ray F White; Frank C Barone; Giora Z Feuerstein
Tumor necrosis factor-alpha expression in ischemic neurons.
Stroke; a journal of cerebral circulation 1994;25(7):1481-8.
1994: Stephen Douglas; CS Louden; L M Vickery-Clark; B L Storer; T Hart; Giora Z Feuerstein; John D Elliott; Eliot ohlstein
A role for endogenous endothelin-1 in neointimal formation after rat carotid artery balloon angioplasty. Protective effects of the novel nonpeptide endothelin receptor antagonist SB 209670.
Circulation research 1994;75(1):190-7.
1994: Tian-Li Yue; X Wang; C P Sung; B Olson; P J McKenna; Juan-li Gu; Giora Z Feuerstein
Interleukin-8. A mitogen and chemoattractant for vascular smooth muscle cells.
Circulation research 1994;75(1):1-7.
1994: Frank C Barone; M Y Globus; W J Price; Ray F White; B L Storer; Giora Z Feuerstein; R Busto; Eliot ohlstein
Endothelin levels increase in rat focal and global ischemia.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1994;14(2):337-42.
1994: Tian-Li Yue; P J McKenna; Juan-li Gu; H Y Cheng; R E Ruffolo; Giora Z Feuerstein
Carvedilol, a new vasodilating beta adrenoceptor blocker antihypertensive drug, protects endothelial cells from damage initiated by xanthine-xanthine oxidase and neutrophils.
Cardiovascular research 1994;28(3):400-6.
1994: Tian-Li Yue; P J Mckenna; PG Lysko; Juan-li Gu; K A Lysko; RR Ruffolo; Giora Z Feuerstein
SB 211475, a metabolite of carvedilol, a novel antihypertensive agent, is a potent antioxidant.
European journal of pharmacology 1994;251(2-3):237-43.
1994: Tian-Li Yue; Giora Z Feuerstein
Platelet-activating factor: a putative neuromodulator and mediator in the pathophysiology of brain injury.
Critical reviews in neurobiology 1994;8(1-2):11-24.
1994: Giora Z Feuerstein; T Liu; Frank C Barone
Cytokines, inflammation, and brain injury: role of tumor necrosis factor-alpha.
Cerebrovascular and brain metabolism reviews 1994;6(4):341-60.
1994: R K Clark; E V Lee; Ray F White; Z L Jonak; Giora Z Feuerstein; Frank C Barone
Reperfusion following focal stroke hastens inflammation and resolution of ischemic injured tissue.
Brain research bulletin 1994;35(4):387-92.
1993: T Liu; Peter Young; P C McDonnell; R F White; Frank C Barone; Giora Z Feuerstein
Cytokine-induced neutrophil chemoattractant mRNA expressed in cerebral ischemia.
Neuroscience letters 1993;164(1-2):125-8.
1993: Tian-Li Yue; P J Mckenna; Juan-li Gu; H Y Cheng; RR Ruffolo; Giora Z Feuerstein
Carvedilol, a new antihypertensive agent, prevents lipid peroxidation and oxidative injury to endothelial cells.
Hypertension 1993;22(6):922-8.
1993: Frank C Barone; R K Clark; W J Price; Ray F White; Giora Z Feuerstein; B L Storer; Eliot ohlstein
Neuron-specific enolase increases in cerebral and systemic circulation following focal ischemia.
Brain research 1993;623(1):77-82.
1993: Tian-Li Yue; P J Mckenna; Juan-li Gu; Giora Z Feuerstein
Interleukin-8 is chemotactic for vascular smooth muscle cells.
European journal of pharmacology 1993;240(1):81-4.
1993: Eliot ohlstein; Stephen Douglas; C P Sung; Tian-Li Yue; CS Louden; Anthony Arleth; G Poste; RR Ruffolo; Giora Z Feuerstein
Carvedilol, a cardiovascular drug, prevents vascular smooth muscle cell proliferation, migration, and neointimal formation following vascular injury.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(13):6189-93.
1993: Frank C Barone; D J Knudsen; A H Nelson; Giora Z Feuerstein; Robert N Willette
Mouse strain differences in susceptibility to cerebral ischemia are related to cerebral vascular anatomy.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1993;13(4):683-92.
1993: Giora Z Feuerstein; Tian-Li Yue; H Y Cheng; RR Ruffolo
Myocardial protection by the novel vasodilating beta-blocker, carvedilol: potential relevance of anti-oxidant activity.
Journal of hypertension. Supplement : official journal of the International Society of Hypertension 1993;11(4):S41-8.
1993: Tian-Li Yue; Frank C Barone; Juan-li Gu; Giora Z Feuerstein
Brain alpha-tocopherol levels are not altered following ischemia/reperfusion-induced cerebral injury in rats and gerbils.
Brain research 1993;610(1):53-6.
1993: R K Clark; E V Lee; C J Fish; Ray F White; W J Price; Z L Jonak; Giora Z Feuerstein; Frank C Barone
Development of tissue damage, inflammation and resolution following stroke: an immunohistochemical and quantitative planimetric study.
Brain research bulletin 1993;31(5):565-72.
1993: RR Ruffolo; A Bril; Giora Z Feuerstein
Cardioprotective potential of carvedilol.
Cardiology 1993;82 Suppl 3():24-8.
1992: Tian-Li Yue; P J McKenna; PG Lysko; RR Ruffolo; Giora Z Feuerstein
Carvedilol, a new antihypertensive, prevents oxidation of human low density lipoprotein by macrophages and copper.
Atherosclerosis 1992;97(2-3):209-16.
1992: Frank C Barone; Dulcie B Schmidt; L M Hillegass; W J Price; Ray F White; Giora Z Feuerstein; R K Clark; E V Lee; Don E Griswold; Henry M Sarau
Reperfusion increases neutrophils and leukotriene B4 receptor binding in rat focal ischemia.
Stroke; a journal of cerebral circulation 1992;23(9):1337-47; discussion 1347-8.
1992: Robert N Willette; Charles F Sauermelch; R Rycyna; S Sarkar; Giora Z Feuerstein; A J Nichols; Eliot ohlstein
Antithrombotic effects of a platelet fibrinogen receptor antagonist in a canine model of carotid artery thrombosis.
Stroke; a journal of cerebral circulation 1992;23(5):703-11.
1992: Frank C Barone; W J Price; Ray F White; R N Willette; Giora Z Feuerstein
Genetic hypertension and increased susceptibility to cerebral ischemia.
Neuroscience and biobehavioral reviews 1992;16(2):219-33.
1992: Giora Z Feuerstein; S A Hamburger; E F Smith; A Bril; RR Ruffolo
Myocardial protection with carvedilol.
Journal of cardiovascular pharmacology 1992;19 Suppl 1():S138-41.
1991: Frank C Barone; L M Hillegass; W J Price; Ray F White; E V Lee; Giora Z Feuerstein; Henry M Sarau; R K Clark; Don E Griswold
Polymorphonuclear leukocyte infiltration into cerebral focal ischemic tissue: myeloperoxidase activity assay and histologic verification.
Journal of neuroscience research 1991;29(3):336-45.
1991: S A Hamburger; Frank C Barone; Giora Z Feuerstein; RR Ruffolo
Carvedilol (Kredex) reduces infarct size in a canine model of acute myocardial infarction.
Pharmacology 1991;43(3):113-20.
1991: C P Sung; Anthony Arleth; B Storer; Giora Z Feuerstein
Modulation of U937 cell adhesion to vascular endothelial cells by cyclic AMP.
Life sciences 1991;49(5):375-82.
1991: C P Sung; Anthony Arleth; Giora Z Feuerstein
Neuropeptide Y upregulates the adhesiveness of human endothelial cells for leukocytes.
Circulation research 1991;68(1):314-8.