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Filomena Fezza

Research Profile

Chemicals & Drugs

Living Beings

Rats
Mouse

Anatomy

Phenomena

Blotting, Western

Physiology

Synaptic Transmission

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Publications

TOP 3
Stefania Butini; Walter Cabri; Giuseppe Campiani; Diana Celona; Sabrina Dallavalle; Filomena Fezza; Sandra Gemma; Samuele Maramai; Lucio Merlini; Patrizia Minetti; Raffaella Napolitano; Franco Borsini; Margherita Brindisi; Mauro Maccarrone
Identification of a novel arylpiperazine scaffold for fatty acid amide hydrolase inhibition with improved drug disposition properties.
Almerinda Di Venere; Filomena Fezza; Alessandro Finazzi-Agrò; Beatrice Clotilde Angelucci; Benjamin F Cravatt; Enrico Dainese; Giampiero Mei; Nicola Rosato; Mauro Maccarrone
Rat and human fatty acid amide hydrolases: overt similarities and hidden differences.
Stefania Butini; Walter Cabri; Giuseppe Campiani; Antonio Caprioli; Stefano Di Serio; Filomena Fezza; Grazia Gallo; Sandra Gemma; Samuele Maramai; Patrizia Minetti; Sindu Ros; M Antonietta Stasi; Emanuela Talamonti; Silvia Vincenti; Giuseppe Borrelli; Franco Borsini; Margherita Brindisi; Mauro Maccarrone
Discovery of potent inhibitors of human and mouse fatty acid amide hydrolases.

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All Publications

2013: Stefania Butini; Walter Cabri; Giuseppe Campiani; Diana Celona; Sabrina Dallavalle; Filomena Fezza; Sandra Gemma; Samuele Maramai; Lucio Merlini; Patrizia Minetti; Raffaella Napolitano; Franco Borsini; Margherita Brindisi; Mauro Maccarrone
Identification of a novel arylpiperazine scaffold for fatty acid amide hydrolase inhibition with improved drug disposition properties.
Bioorganic & medicinal chemistry letters 2013;23(2):492-5.
2012: Almerinda Di Venere; Filomena Fezza; Alessandro Finazzi-Agrò; Beatrice Clotilde Angelucci; Benjamin F Cravatt; Enrico Dainese; Giampiero Mei; Nicola Rosato; Mauro Maccarrone
Rat and human fatty acid amide hydrolases: overt similarities and hidden differences.
Biochimica et biophysica acta 2012;1821(11):1425-33.
2012: Stefania Butini; Walter Cabri; Giuseppe Campiani; Antonio Caprioli; Stefano Di Serio; Filomena Fezza; Grazia Gallo; Sandra Gemma; Samuele Maramai; Patrizia Minetti; Sindu Ros; M Antonietta Stasi; Emanuela Talamonti; Silvia Vincenti; Giuseppe Borrelli; Franco Borsini; Margherita Brindisi; Mauro Maccarrone
Discovery of potent inhibitors of human and mouse fatty acid amide hydrolases.
Journal of medicinal chemistry 2012;55(15):6898-915.
2012: Mariangela Pucci; Cinzia Rapino; Michela Zuccolo; Nicoletta Pasquariello; Natalia Battista; Lionel Breton; Monia Di Tommaso; Filomena Fezza; Alessandro Finazzi-Agrò; Roland Jourdain; Mauro Maccarrone
Endocannabinoids stimulate human melanogenesis via type-1 cannabinoid receptor.
The Journal of biological chemistry 2012;287(19):15466-78.
2012: Sergio Oddi; Simone Sandiford; Jana Selent; Antonio Totaro; Somnath Mukhopadhyay; Daniela Barcaroli; Giuseppina Catanzaro; Diego Centonze; Valerio Chiurchiù; Enrico Dainese; Vincenzo de Laurenzi; Filomena Fezza; Allyn C Howlett; Mirko Lanuti; Mauro Maccarrone
Effects of palmitoylation of Cys(415) in helix 8 of the CB(1) cannabinoid receptor on membrane localization and signalling.
British journal of pharmacology 2012;165(8):2635-51.
2011: Sergio Oddi; Enrico Dainese; Filomena Fezza; Mirko Lanuti; Daniela Barcaroli; Vincenzo De Laurenzi; Diego Centonze; Mauro Maccarrone
Functional characterization of putative cholesterol binding sequence (CRAC) in human type-1 cannabinoid receptor.
Journal of neurochemistry 2011;116(5):858-65.
2010: Sonia Gattinoni; Chiara De Simone; Sabrina Dallavalle; Filomena Fezza; Raffaella Nannei; Natalia Battista; Patrizia Minetti; Gianandrea Quattrociocchi; Antonio Caprioli; Franco Borsini; Walter Cabri; Sergio Penco; Lucio Merlini; Mauro Maccarrone
A new group of oxime carbamates as reversible inhibitors of fatty acid amide hydrolase.
Bioorganic & medicinal chemistry letters 2010;20(15):4406-11.
2010: Sergio Oddi; Filomena Fezza; Giuseppina Catanzaro; Chiara De Simone; Mariangela Pucci; Daniele Piomelli; Alessandro Finazzi-Agrò; Mauro Maccarrone
Pitfalls and solutions in assaying anandamide transport in cells.
Journal of lipid research 2010;51(8):2435-44.
2010: Valerio Pisani; Vincenzo Moschella; Monica Bari; Filomena Fezza; Salvatore Galati; Giorgio Bernardi; Paolo Stanzione; Antonio Pisani; Mauro Maccarrone
Dynamic changes of anandamide in the cerebrospinal fluid of Parkinson's disease patients.
Movement disorders : official journal of the Movement Disorder Society 2010;25(7):920-4.
2010: Daniele Amadio; Filomena Fezza; Giuseppina Catanzaro; Ottaviano Incani; Guus van Zadelhoff; Alessandro Finazzi-Agrò; Mauro Maccarrone
Methylation and acetylation of 15-hydroxyanandamide modulate its interaction with the endocannabinoid system.
Biochimie 2010;92(4):378-87.
2010: Sonia Gattinoni; Chiara De Simone; Sabrina Dallavalle; Filomena Fezza; Raffaella Nannei; Daniele Amadio; Patrizia Minetti; Gianandrea Quattrociocchi; Antonio Caprioli; Franco Borsini; Walter Cabri; Sergio Penco; Lucio Merlini; Mauro Maccarrone
Enol carbamates as inhibitors of fatty acid amide hydrolase (FAAH) endowed with high selectivity for FAAH over the other targets of the endocannabinoid system.
ChemMedChem 2010;5(3):357-60.
2009: Sergio Oddi; Filomena Fezza; Nicoletta Pasquariello; Antonella D'Agostino; Giuseppina Catanzaro; Chiara De Simone; Cinzia Rapino; Alessandro Finazzi-Agrò; Mauro Maccarrone
Molecular identification of albumin and Hsp70 as cytosolic anandamide-binding proteins.
Chemistry & biology 2009;16(6):624-32.
2008: Filomena Fezza; Sergio Oddi; Monia Di Tommaso; Chiara De Simone; Cinzia Rapino; Nicoletta Pasquariello; Enrico Dainese; Alessandro Finazzi-Agrò; Mauro Maccarrone
Characterization of biotin-anandamide, a novel tool for the visualization of anandamide accumulation.
Journal of lipid research 2008;49(6):1216-23.
2008: Sergio Oddi; Filomena Fezza; Nicoletta Pasquariello; C De Simone; C Rapino; Enrico Dainese; Alessandro Finazzi-Agrò; Mauro Maccarrone
Evidence for the intracellular accumulation of anandamide in adiposomes.
Cellular and molecular life sciences : CMLS 2008;65(5):840-50.
2008: Mauro Maccarrone; Silvia Rossi; Monica Bari; Valentina De Chiara; Filomena Fezza; Alessandra Musella; Valeria Gasperi; Chiara Prosperetti; Giorgio Bernardi; Alessandro Finazzi-Agrò; Benjamin F Cravatt; Diego Centonze
Anandamide inhibits metabolism and physiological actions of 2-arachidonoylglycerol in the striatum.
Nature neuroscience 2008;11(2):152-9.
2008: Paola Massi; M Valenti; Angelo Vaccani; Valeria Gasperi; Gianpaolo Perletti; Emanuela Marras; Filomena Fezza; Mauro Maccarrone; Daniela Parolaro
5-Lipoxygenase and anandamide hydrolase (FAAH) mediate the antitumor activity of cannabidiol, a non-psychoactive cannabinoid.
Journal of neurochemistry 2008;104(4):1091-100.
2008: Filomena Fezza; Chiara De Simone; Daniele Amadio; Mauro Maccarrone
Fatty acid amide hydrolase: a gate-keeper of the endocannabinoid system.
Sub-cellular biochemistry 2008;49():101-32.
2007: Diego Centonze; Monica Bari; Silvia Rossi; Chiara Prosperetti; Roberto Furlan; Filomena Fezza; Valentina De Chiara; Luca Battistini; Giorgio Bernardi; Sergio Bernardini; Gianvito Martino; Mauro Maccarrone
The endocannabinoid system is dysregulated in multiple sclerosis and in experimental autoimmune encephalomyelitis.
Brain : a journal of neurology 2007;130(Pt 10):2543-53.
2007: Diana Amantea; Paola Spagnuolo; Monica Bari; Filomena Fezza; Cinzia Mazzei; Cristina Tassorelli; Luigi A Morrone; M Tiziana Corasaniti; Mauro Maccarrone; Giacinto Bagetta
Modulation of the endocannabinoid system by focal brain ischemia in the rat is involved in neuroprotection afforded by 17beta-estradiol.
The FEBS journal 2007;274(17):4464-775.
2007: Diego Centonze; Silvia Rossi; Ilaria Napoli; Valentina Mercaldo; Caroline Lacoux; Francesca Ferrari; Maria Teresa Ciotti; Valentina De Chiara; Chiara Prosperetti; Mauro Maccarrone; Filomena Fezza; Paolo Calabresi; Giorgio Bernardi; Claudia Bagni
The brain cytoplasmic RNA BC1 regulates dopamine D2 receptor-mediated transmission in the striatum.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(33):8885-92.
2007: Silvia Marinelli; Vincenzo Di Marzo; Fulvio Florenzano; Filomena Fezza; Maria Teresa Viscomi; Mario van der Stelt; Giorgio Bernardi; Marco Molinari; Mauro Maccarrone; Nicola B Mercuri
N-arachidonoyl-dopamine tunes synaptic transmission onto dopaminergic neurons by activating both cannabinoid and vanilloid receptors.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2007;32(2):298-308.
2007: Valeria Gasperi; Filomena Fezza; Nicoletta Pasquariello; Monica Bari; Sergio Oddi; Alessandro Finazzi Agrò; Mauro Maccarrone
Endocannabinoids in adipocytes during differentiation and their role in glucose uptake.
Cellular and molecular life sciences : CMLS 2007;64(2):219-29.
2006: Belinda Spoto; Filomena Fezza; G Parlongo; Natalia Battista; E Sgro'; Valeria Gasperi; Carmine Zoccali; Mauro Maccarrone
Human adipose tissue binds and metabolizes the endocannabinoids anandamide and 2-arachidonoylglycerol.
Biochimie 2006;88(12):1889-97.
2006: Monica Bari; Paola Spagnuolo; Filomena Fezza; Sergio Oddi; Nicoletta Pasquariello; Alessandro Finazzi-Agrò; Mauro Maccarrone
Effect of lipid rafts on Cb2 receptor signaling and 2-arachidonoyl-glycerol metabolism in human immune cells.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(8):4971-80.
2006: Natalia Battista; Filomena Fezza; Alessandro Finazzi-Agrò; Mauro Maccarrone
The endocannabinoid system in neurodegeneration.
The Italian journal of biochemistry 2006;55(3-4):283-9.
2006: Monica Bari; Natalia Battista; Filomena Fezza; Valeria Gasperi; Mauro Maccarrone
New insights into endocannabinoid degradation and its therapeutic potential.
Mini reviews in medicinal chemistry 2006;6(3):257-68.
2006: Filomena Fezza; Natalia Battista; Monica Bari; Mauro Maccarrone
Methods to assay anandamide hydrolysis and transport in synaptosomes.
Methods in molecular medicine 2006;123():163-8.
2005: Ana Cabranes; Katerina Venderova; Eva de Lago; Filomena Fezza; Antonio Sánchez; Leyre Mestre; Marta Valenti; Antonio García-Merino; José A Ramos; Vincenzo Di Marzo; Javier Fernández-Ruiz
Decreased endocannabinoid levels in the brain and beneficial effects of agents activating cannabinoid and/or vanilloid receptors in a rat model of multiple sclerosis.
Neurobiology of disease 2005;20(2):207-17.
2005: Valeria Gasperi; Filomena Fezza; Paola Spagnuolo; Nicoletta Pasquariello; Mauro Maccarrone
Further insights into the regulation of human FAAH by progesterone and leptin implications for endogenous levels of anandamide and apoptosis of immune and neuronal cells.
Neurotoxicology 2005;26(5):811-7.
2005: Mauro Maccarrone; Barbara Barboni; Andrea Paradisi; Nicola Bernabò; Valeria Gasperi; Maria Gabriella Pistilli; Filomena Fezza; Pia Lucidi; Mauro Mattioli
Characterization of the endocannabinoid system in boar spermatozoa and implications for sperm capacitation and acrosome reaction.
Journal of cell science 2005;118(Pt 19):4393-404.
2005: Antonio Pisani; Filomena Fezza; Salvatore Galati; Natalia Battista; Simone Napolitano; Alessandro Finazzi-Agrò; Giorgio Bernardi; Livia Brusa; Mariangela Pierantozzi; Paolo Stanzione; Mauro Maccarrone
High endogenous cannabinoid levels in the cerebrospinal fluid of untreated Parkinson's disease patients.
Annals of neurology 2005;57(5):777-9.
2005: Filomena Fezza; Valeria Gasperi; Cinzia Mazzei; Mauro Maccarrone
Radiochromatographic assay of N-acyl-phosphatidylethanolamine-specific phospholipase D activity.
Analytical biochemistry 2005;339(1):113-20.
2005: Monica Bari; Natalia Battista; Filomena Fezza; Alessandro Finazzi-Agrò; Mauro Maccarrone
Lipid rafts control signaling of type-1 cannabinoid receptors in neuronal cells. Implications for anandamide-induced apoptosis.
The Journal of biological chemistry 2005;280(13):12212-20.
2004: Mauro Maccarrone; Valeria Gasperi; Filomena Fezza; Alessandro Finazzi-Agrò; Antonello Rossi
Differential regulation of fatty acid amide hydrolase promoter in human immune cells and neuronal cells by leptin and progesterone.
European journal of biochemistry / FEBS 2004;271(23-24):4666-76.
2004: Sara González; Marta Valenti; Rosario De Miguel; Filomena Fezza; Javier Fernández-Ruiz; Vincenzo Di Marzo; José A Ramos
Changes in endocannabinoid contents in reward-related brain regions of alcohol-exposed rats, and their possible relevance to alcohol relapse.
British journal of pharmacology 2004;143(4):455-64.
2004: Isabel Matias; June Chen; Luciano De Petrocellis; Tiziana Bisogno; Alessia Ligresti; Filomena Fezza; Achim H-P Krauss; L Shi; Charles E Protzman; Chen Li; Yanbin Liang; Amelia L Nieves; KM Kedzie; Robert M Burk; Vincenzo Di Marzo; David F Woodward
Prostaglandin ethanolamides (prostamides): in vitro pharmacology and metabolism.
The Journal of pharmacology and experimental therapeutics 2004;309(2):745-57.
2004: Natalia Battista; Filomena Fezza; Mauro Maccarrone
Endocannabinoids and their involvement in the neurovascular system.
Current neurovascular research 2004;1(2):129-40.
2004: Mauro Maccarrone; M DeFelici; Francesca Gioia Klinger; Natalia Battista; Filomena Fezza; Enrico Dainese; G Siracusa; Alessandro Finazzi-Agrò
Mouse blastocysts release a lipid which activates anandamide hydrolase in intact uterus.
Molecular human reproduction 2004;10(4):215-21.
2004: Mauro Maccarrone; Filomena Fezza; Alessandro Finazzi-Agrò
Levels of N-acylethanolamines in human tumors: in search of reliable data.
Lipids 2004;39(2):193-4.
2003: Nicola De Marchi; Luciano De Petrocellis; Pierangelo Orlando; Fabiana Daniele; Filomena Fezza; Vincenzo Di Marzo
Endocannabinoid signalling in the blood of patients with schizophrenia.
Lipids in health and disease 2003;2():5.
2003: Filomena Fezza; Jack W Dillwith; Tiziana Bisogno; James S Tucker; Vincenzo Di Marzo; John R Sauer
Endocannabinoids and related fatty acid amides, and their regulation, in the salivary glands of the lone star tick.
Biochimica et biophysica acta 2003;1633(1):61-7.
2003: Daniela Viganò; Maria Grazia Cascio; Tiziana Rubino; Filomena Fezza; Angelo Vaccani; Vincenzo Di Marzo; Daniela Parolaro
Chronic morphine modulates the contents of the endocannabinoid, 2-arachidonoyl glycerol, in rat brain.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2003;28(6):1160-7.
2003: Wouter B Veldhuis; Mario van der Stelt; M W Wadman; Guus van Zadelhoff; Mauro Maccarrone; Filomena Fezza; Gerrit A Veldink; Johannes Vliegenthart; Peter R Bär; Klaas Nicolay; Vincenzo Di Marzo
Neuroprotection by the endogenous cannabinoid anandamide and arvanil against in vivo excitotoxicity in the rat: role of vanilloid receptors and lipoxygenases.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(10):4127-33.
2002: Sara González; Maria Grazia Cascio; Javier Fernández-Ruiz; Filomena Fezza; Vincenzo Di Marzo; José A Ramos
Changes in endocannabinoid contents in the brain of rats chronically exposed to nicotine, ethanol or cocaine.
Brain research 2002;954(1):73-81.
2002: Susan M Huang; Tiziana Bisogno; Marcello Trevisani; Abdulmonem Al-Hayani; Luciano De Petrocellis; Filomena Fezza; Michele Tognetto; Timothy J Petros; Jocelyn F Krey; Constance J Chu; Jeffrey D Miller; Stephen N Davies; Pierangelo Geppetti; J Michael Walker; Vincenzo Di Marzo
An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(12):8400-5.
2002: Tim C Kirkham; Claire M Williams; Filomena Fezza; Vincenzo Di Marzo
Endocannabinoid levels in rat limbic forebrain and hypothalamus in relation to fasting, feeding and satiation: stimulation of eating by 2-arachidonoyl glycerol.
British journal of pharmacology 2002;136(4):550-7.
2002: Filomena Fezza; Tiziana Bisogno; Alberto Minassi; Giovanni Appendino; Urij Rampampam; Vincenzo Di Marzo
Noladin ether, a putative novel endocannabinoid: inactivation mechanisms and a sensitive method for its quantification in rat tissues.
FEBS letters 2002;513(2-3):294-8.
2002: Tibor Wenger; Ida Gerendai; Filomena Fezza; Sara González; Tiziana Bisogno; Javier Fernandez-Ruiz; Vincenzo Di Marzo
The hypothalamic levels of the endocannabinoid, anandamide, peak immediately before the onset of puberty in female rats.
Life sciences 2002;70(12):1407-14.
2002: Vincenzo Di Marzo; Luciano De Petrocellis; Filomena Fezza; Alessia Ligresti; Tiziana Bisogno
Anandamide receptors.
Prostaglandins, leukotrienes, and essential fatty acids 2002;66(2-3):377-91.
2002: Mauro Maccarrone; Tiziana Bisogno; Herbert Valensise; Natalia Lazzarin; Filomena Fezza; Claudio Manna; Vincenzo Di Marzo; Alessandro Finazzi-Agrò
Low fatty acid amide hydrolase and high anandamide levels are associated with failure to achieve an ongoing pregnancy after IVF and embryo transfer.
Molecular human reproduction 2002;8(2):188-95.
2001: Mario van der Stelt; Wouter B Veldhuis; G W van Haaften; Filomena Fezza; T Bisogno; P R Bar; Gerrit A Veldink; Johannes Vliegenthart; Vincenzo Di Marzo; Klaas Nicolay
Exogenous anandamide protects rat brain against acute neuronal injury in vivo.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(22):8765-71.
2001: Mauro Maccarrone; L De Petrocellis; Monica Bari; Filomena Fezza; S Salvati; Vincenzo Di Marzo; Alessandro Finazzi-Agrò
Lipopolysaccharide downregulates fatty acid amide hydrolase expression and increases anandamide levels in human peripheral lymphocytes.
Archives of biochemistry and biophysics 2001;393(2):321-8.
2001: Isabel Lastres-Becker; Filomena Fezza; Maribel Cebeira; Tiziana Bisogno; José A Ramos; A Milone; Javier Fernández-Ruiz; Vincenzo Di Marzo
Changes in endocannabinoid transmission in the basal ganglia in a rat model of Huntington's disease.
Neuroreport 2001;12(10):2125-9.
2001: Uberto Pagotto; Giovanni Marsicano; Filomena Fezza; Marily Theodoropoulou; Yvonne Grübler; Johanna Stalla; Thomas Arzberger; A Milone; Marco Losa; Vincenzo Di Marzo; Beat Lutz; Günter K Stalla
Normal human pituitary gland and pituitary adenomas express cannabinoid receptor type 1 and synthesize endogenous cannabinoids: first evidence for a direct role of cannabinoids on hormone modulation at the human pituitary level.
The Journal of clinical endocrinology and metabolism 2001;86(6):2687-96.