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Isaiah Fidler

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TOP 3
Robert R Langley; Isaiah J Fidler
The biology of brain metastasis.
Isaiah J Fidler
Biological heterogeneity of cancer: implication to therapy.
Sun-Jin Kim; Seung Wook Kim; François Lehembre; Urs Regenass; Panja Strickner; Seok Joong Yun; Emily Brantley; Dominic Fan; Junqin He; Jang-Seong Kim; Isaiah J Fidler
Antivascular therapy for multidrug-resistant ovarian tumors by macitentan, a dual endothelin receptor antagonist.

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All Publications

2013: Robert R Langley; Isaiah J Fidler
The biology of brain metastasis.
Clinical chemistry 2013;59(1):180-9.
2012: Isaiah J Fidler
Biological heterogeneity of cancer: implication to therapy.
Human vaccines & immunotherapeutics 2012;8(8):1141-2.
2012: Sun-Jin Kim; Seung Wook Kim; François Lehembre; Urs Regenass; Panja Strickner; Seok Joong Yun; Emily Brantley; Dominic Fan; Junqin He; Jang-Seong Kim; Isaiah J Fidler
Antivascular therapy for multidrug-resistant ovarian tumors by macitentan, a dual endothelin receptor antagonist.
Translational oncology 2012;5(1):39-47.
2011: Eun Sung Park; Yun-Yong Park; hyun goo woo; Se-Lyun Yoon; Jae-Ho Cheong; Isaiah J Fidler; Sang-Bae Kim; Sun Jin Kim; Soo Mi Kim; Seung Wook Kim; Sun-Hee Leem; Gordon B Mills; Ju Seog Lee
Cross-species hybridization of microarrays for studying tumor transcriptome of brain metastasis.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(42):17456-61.
2011: Zhang Weihua; Dominic Fan; Qingtang Lin; Asa J Ramoth; Isaiah J Fidler
Formation of solid tumors by a single multinucleated cancer cell.
Cancer 2011;117(17):4092-9.
2011: Seung Wook Kim; Jang-Seong Kim; John Papadopoulos; Hyun Jin Choi; Junqin He; Marva Maya; Robert R Langley; Dominic Fan; Isaiah J Fidler; Sun-Jin Kim
Consistent interactions between tumor cell IL-6 and macrophage TNF-α enhance the growth of human prostate cancer cells in the bone of nude mouse.
International immunopharmacology 2011;11(7):862-72.
2011: Robert R Langley; Isaiah J Fidler
The seed and soil hypothesis revisited--the role of tumor-stroma interactions in metastasis to different organs.
International journal of cancer. Journal international du cancer 2011;128(11):2527-35.
2011: Lixia Guo; Dominic Fan; Fahao Zhang; Janet E Price; Ju Seog Lee; Dario Marchetti; Isaiah J Fidler; Robert R Langley
Selection of brain metastasis-initiating breast cancer cells determined by growth on hard agar.
The American journal of pathology 2011;178(5):2357-66.
2011: Isaiah J Fidler
The role of the organ microenvironment in brain metastasis.
Seminars in cancer biology 2011;21(2):107-12.
2011: Isaiah J Fidler
The biology of cancer metastasis.
Seminars in cancer biology 2011;21(2):71.
2011: Sun-Jin Kim; Jang-Seong Kim; Eun Sung Park; Ju Seog Lee; Qingtang Lin; Robert R Langley; Marva Maya; Junqin He; Seung-Wook Kim; Weihua Zhang; Krishnakumar Balasubramanian; Dominic Fan; Gordon B Mills; Mien-Chie Hung; Isaiah J Fidler
Astrocytes upregulate survival genes in tumor cells and induce protection from chemotherapy.
Neoplasia (New York, N.Y.) 2011;13(3):286-98.
2011: Sun-Jin Kim; Jang-Seong Kim; Seung Wook Kim; Emily Brantley; Seok Joong Yun; Junqin He; Marva Maya; Fahao Zhang; Qiuyu Wu; François Lehembre; Urs Regenass; Isaiah J Fidler
Macitentan (ACT-064992), a tissue-targeting endothelin receptor antagonist, enhances therapeutic efficacy of paclitaxel by modulating survival pathways in orthotopic models of metastatic human ovarian cancer.
Neoplasia (New York, N.Y.) 2011;13(2):167-79.
2011: Kenji Yokoi; David Hawke; Carol J Oborn; Jin-Young Jang; Yasuhiko Nishioka; Dominic Fan; Seung Wook Kim; Sun-Jin Kim; Isaiah J Fidler
Identification and validation of SRC and phospho-SRC family proteins in circulating mononuclear cells as novel biomarkers for pancreatic cancer.
Translational oncology 2011;4(2):83-91.
2010: Qingtang Lin; Krishnakumar Balasubramanian; Dominic Fan; Sun-Jin Kim; Lixia Guo; Hua Wang; Menashe Bar-Eli; Kenneth Aldape; Isaiah J Fidler
Reactive astrocytes protect melanoma cells from chemotherapy by sequestering intracellular calcium through gap junction communication channels.
Neoplasia (New York, N.Y.) 2010;12(9):748-54.
2010: Lee M Ellis; Isaiah J Fidler
Finding the tumor copycat. Therapy fails, patients don't.
Nature medicine 2010;16(9):974-5.
2010: Isaiah J Fidler; Krishnakumar Balasubramanian; Qingtang Lin; Seung Wook Kim; Sun-Jin Kim
The brain microenvironment and cancer metastasis.
Molecules and cells 2010;30(2):93-8.
2010: James Edward Talmadge; Isaiah J Fidler
AACR centennial series: the biology of cancer metastasis: historical perspective.
Cancer research 2010;70(14):5649-69.
2010: robert rebhun; Hua Cheng; Jeffrey E Gershenwald; Dominic Fan; Isaiah J Fidler; Robert R Langley
Constitutive expression of the alpha4 integrin correlates with tumorigenicity and lymph node metastasis of the B16 murine melanoma.
Neoplasia (New York, N.Y.) 2010;12(2):173-82.
2010: Emily C Brantley; Lixia Guo; Chenyu Zhang; Qingtang Lin; Kenji Yokoi; Robert R Langley; Ewa Kruzel; Marva Maya; Seung Wook Kim; Sun-Jin Kim; Dominic Fan; Isaiah J Fidler
Nitric oxide-mediated tumoricidal activity of murine microglial cells.
Translational oncology 2010;3(6):380-8.
2010: Hsu-Ping Kuo; Dung-Fang Lee; Chun-Te Chen; Mo Liu; Chao-Kai Chou; Hong-Jen Lee; Yi Du; Xiaoming Xie; Yongkun Wei; Weiya Xia; Zhang Weihua; Jer-Yen Yang; Chia-Jui Yen; Tzu-Hsuan Huang; Minjia Tan; Gang Xing; Yingming Zhao; Chien-Hsing Lin; Shih-Feng Tsai; Isaiah J Fidler; Mien-Chie Hung
ARD1 stabilization of TSC2 suppresses tumorigenesis through the mTOR signaling pathway.
Science signaling 2010;3(108):ra9.
2009: Robert R Langley; Dominic Fan; Lixia Guo; Chenyu Zhang; Qingtang Lin; Emily C Brantley; Joseph H McCarty; Isaiah J Fidler
Generation of an immortalized astrocyte cell line from H-2Kb-tsA58 mice to study the role of astrocytes in brain metastasis.
International journal of oncology 2009;35(4):665-72.
2009: Sun-Jin Kim; Jang-Seong Kim; John Papadopoulos; Seung Wook Kim; Marva Maya; Fahao Zhang; Junquin He; Dominic Fan; Robert Langley; Isaiah J Fidler
Circulating monocytes expressing CD31: implications for acute and chronic angiogenesis.
The American journal of pathology 2009;174(5):1972-80.
2009: Chenyu Zhang; Fahao Zhang; Rachel Tsan; Isaiah J Fidler
Transforming growth factor-beta2 is a molecular determinant for site-specific melanoma metastasis in the brain.
Cancer research 2009;69(3):828-35.
2008: Paul Mathew; Peter F Thall; Sijin Wen; Corazon D Bucana; D Jones; E Horne; William K Oh; Michael J Morris; Y-C Lee; Christopher J Logothetis; S-H Lin; Isaiah J Fidler
Dynamic change in phosphorylated platelet-derived growth factor receptor in peripheral blood leukocytes following docetaxel therapy predicts progression-free and overall survival in prostate cancer.
British journal of cancer 2008;99(9):1426-32.
2008: Ricardo Giordano; Johanna Lahdenranta; Lijie Zhen; Ugonma Chukwueke; Irina Petrache; Robert R Langley; Isaiah J Fidler; Renata Pasqualini; Rubin M Tuder; Wadih Arap
Targeted induction of lung endothelial cell apoptosis causes emphysema-like changes in the mouse.
The Journal of biological chemistry 2008;283(43):29447-60.
2008: Isaiah J Fidler; George Poste
The "seed and soil" hypothesis revisited.
The lancet oncology 2008;9(8):808.
2008: Takamitsu Sasaki; Toru Nakamura; robert rebhun; Hua Cheng; Katherine Stemke Hale; Rachel Tsan; Isaiah J Fidler; Robert R Langley
Modification of the primary tumor microenvironment by transforming growth factor alpha-epidermal growth factor receptor signaling promotes metastasis in an orthotopic colon cancer model.
The American journal of pathology 2008;173(1):205-16.
2008: Toshio Kuwai; Toru Nakamura; Takamitsu Sasaki; Sun-Jin Kim; Dominic Fan; Gabriel J Villares; Maya Zigler; Hua Wang; Menashe Bar-Eli; Robert S Kerbel; Isaiah J Fidler
Phosphorylated epidermal growth factor receptor on tumor-associated endothelial cells is a primary target for therapy with tyrosine kinase inhibitors.
Neoplasia (New York, N.Y.) 2008;10(5):489-500.
2008: Weihua Zhang; Rachel Tsan; Huang Wei-Chien; Qiuyu Wu; Chao-Hua Chiu; Isaiah J Fidler; Mien-Chie Hung
Survival of cancer cells is maintained by EGFR independent of its kinase activity.
Cancer cell 2008;13(5):385-93.
2008: Toshio Kuwai; Toru Nakamura; Sun-Jin Kim; Takamitsu Sasaki; Yasuhiko Kitadai; Robert R Langley; Dominic Fan; Stanley R Hamilton; Isaiah J Fidler
Intratumoral heterogeneity for expression of tyrosine kinase growth factor receptors in human colon cancer surgical specimens and orthotopic tumors.
The American journal of pathology 2008;172(2):358-66.
2008: Toshio Kuwai; Toru Nakamura; Takamitsu Sasaki; Yasuhiko Kitadai; Jang-Seong Kim; Robert R Langley; Dominic Fan; Xuemei Wang; Kim-Anh Do; Sun-Jin Kim; Isaiah J Fidler
Targeting the EGFR, VEGFR, and PDGFR on colon cancer cells and stromal cells is required for therapy.
Clinical & experimental metastasis 2008;25(4):477-89.
2008: robert rebhun; Alexander Lazar; Isaiah J Fidler; jeffrey gershenwald
Impact of sentinel lymphadenectomy on survival in a murine model of melanoma.
Clinical & experimental metastasis 2008;25(3):191-9.
2007: Takamitsu Sasaki; Yasuhiko Kitadai; Toru Nakamura; Jang-Seong Kim; Rachel Tsan; Toshio Kuwai; Robert R Langley; Dominic Fan; Sun-Jin Kim; Isaiah J Fidler
Inhibition of epidermal growth factor receptor and vascular endothelial growth factor receptor phosphorylation on tumor-associated endothelial cells leads to treatment of orthotopic human colon cancer in nude mice.
Neoplasia (New York, N.Y.) 2007;9(12):1066-77.
2007: Toru Nakamura; Toshio Kuwai; Jang-Seong Kim; Dominic Fan; Sun-Jin Kim; Isaiah J Fidler
Stromal metalloproteinase-9 is essential to angiogenesis and progressive growth of orthotopic human pancreatic cancer in parabiont nude mice.
Neoplasia (New York, N.Y.) 2007;9(11):979-86.
2007: Wenjuan Wu; Michael S O'Reilly; Robert R Langley; Rachel Tsan; Cheryl H Baker; Neby Bekele; Xi Ming Tang; Amir Onn; Isaiah J Fidler; Roy S Herbst
Expression of epidermal growth factor (EGF)/transforming growth factor-alpha by human lung cancer cells determines their response to EGF receptor tyrosine kinase inhibition in the lungs of mice.
Molecular cancer therapeutics 2007;6(10):2652-63.
2007: Paul Mathew; Peter F Thall; Corazon D Bucana; William K Oh; Michael J Morris; Donnah M Jones; Marcella M Johnson; Sijin Wen; Lance C Pagliaro; Nizar M Tannir; Shi-Ming Tu; Anthony A Meluch; Lon Smith; Lorenzo Cohen; Sun-Jin Kim; Patricia Troncoso; Isaiah J Fidler; Christopher J Logothetis
Platelet-derived growth factor receptor inhibition and chemotherapy for castration-resistant prostate cancer with bone metastases.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(19):5816-24.
2007: Toru Nakamura; Toshio Kuwai; Yasuhiko Kitadai; Takamitsu Sasaki; Dominic Fan; Kevin R Coombes; Sun-Jin Kim; Isaiah J Fidler
Zonal heterogeneity for gene expression in human pancreatic carcinoma.
Cancer research 2007;67(16):7597-604.
2007: Isaiah J Fidler; Sun-Jin Kim; Robert R Langley
The role of the organ microenvironment in the biology and therapy of cancer metastasis.
Journal of cellular biochemistry 2007;101(4):927-36.
2007: Robert R Langley; Isaiah J Fidler
Tumor cell-organ microenvironment interactions in the pathogenesis of cancer metastasis.
Endocrine reviews 2007;28(3):297-321.
2007: James Edward Talmadge; Rakesh K Singh; Isaiah J Fidler; Avraham Raz
Murine models to evaluate novel and conventional therapeutic strategies for cancer.
The American journal of pathology 2007;170(3):793-804.
2007: Wenjuan Wu; Amir Onn; Takeshi Isobe; Satoshi Itasaka; Robert R Langley; Tomoaki Shitani; Keiko Shibuya; Ritsuko Komaki; Anderson Ryan; Isaiah J Fidler; Roy S Herbst; Michael S O'Reilly
Targeted therapy of orthotopic human lung cancer by combined vascular endothelial growth factor and epidermal growth factor receptor signaling blockade.
Molecular cancer therapeutics 2007;6(2):471-83.
2007: Toru Nakamura; Isaiah J Fidler; Kevin R Coombes
Gene expression profile of metastatic human pancreatic cancer cells depends on the organ microenvironment.
Cancer research 2007;67(1):139-48.
2006: Yasuhiko Kitadai; Takamitsu Sasaki; Toshio Kuwai; Toru Nakamura; Corazon D Bucana; Isaiah J Fidler
Targeting the expression of platelet-derived growth factor receptor by reactive stroma inhibits growth and metastasis of human colon carcinoma.
The American journal of pathology 2006;169(6):2054-65.
2006: J Erik Busby; Sun-Jin Kim; Sertac Yazici; Toru Nakamura; Jang-Seong Kim; Junqin He; Marva Maya; Xuemei Wang; Kim-Anh Do; Dominic Fan; Isaiah J Fidler
Therapy of multidrug resistant human prostate tumors in the prostate of nude mice by simultaneous targeting of the epidermal growth factor receptor and vascular endothelial growth factor receptor on tumor-associated endothelial cells.
The Prostate 2006;66(16):1788-98.
2006: Yasuhiko Kitadai; Takamitsu Sasaki; Toshio Kuwai; Toru Nakamura; Corazon D Bucana; Stanley R Hamilton; Isaiah J Fidler
Expression of activated platelet-derived growth factor receptor in stromal cells of human colon carcinomas is associated with metastatic potential.
International journal of cancer. Journal international du cancer 2006;119(11):2567-74.
2006: Isaiah J Fidler
Models for spontaneous metastasis.
Cancer research 2006;66(19):9787.
2006: robert rebhun; Robert R Langley; Kenji Yokoi; Dominic Fan; jeffrey gershenwald; Isaiah J Fidler
Targeting receptor tyrosine kinase on lymphatic endothelial cells for the therapy of colon cancer lymph node metastasis.
Neoplasia (New York, N.Y.) 2006;8(9):747-57.
2006: Isaiah J Fidler
Antivascular therapy of cancer metastasis.
Journal of surgical oncology 2006;94(3):178-80.
2006: Weihua Zhang; Rachel Tsan; Do-Hyun Nam; Weixin Lu; Isaiah J Fidler
Loss of adhesion in the circulation converts amelanotic metastatic melanoma cells to melanotic by inhibition of AKT.
Neoplasia (New York, N.Y.) 2006;8(7):543-50.
2006: Cheryl H Baker; Jose G Trevino; Justin M Summy; Fahao Zhang; Alexis Caron; Mark Nesbit; Gary E Gallick; Isaiah J Fidler
Inhibition of PDGFR phosphorylation and Src and Akt activity by GN963 leads to therapy of human pancreatic cancer growing orthotopically in nude mice.
International journal of oncology 2006;29(1):125-38.
2006: Sun-Jin Kim; Hisanori Uehara; Sertac Yazici; J Erik Busby; Toru Nakamura; Junqin He; Marva Maya; Christopher Logothetis; Paul Mathew; Xuemei Wang; Kim-Anh Do; Dominic Fan; Isaiah J Fidler
Targeting platelet-derived growth factor receptor on endothelial cells of multidrug-resistant prostate cancer.
Journal of the National Cancer Institute 2006;98(11):783-93.
2006: Cheryl H Baker; Maria S Pino; Isaiah J Fidler
Phosphorylated epidermal growth factor receptor on tumor-associated endothelial cells in human renal cell carcinoma is a primary target for therapy by tyrosine kinase inhibitors.
Neoplasia (New York, N.Y.) 2006;8(6):470-6.
2005: Weihua Zhang; Rachel Tsan; Alan J Schroit; Isaiah J Fidler
Apoptotic cells initiate endothelial cell sprouting via electrostatic signaling.
Cancer research 2005;65(24):11529-35.
2005: Isaiah J Fidler
Blockade of the TGF-beta superfamily by Smad7: breaking a link in the metastatic chain.
Journal of the National Cancer Institute 2005;97(23):1714-5.
2005: Hua Cheng; Robert R Langley; Qiuyu Wu; Wenjuan Wu; Jie Feng; Rachel Tsan; Dominic Fan; Isaiah J Fidler
Construction of a novel constitutively active chimeric EGFR to identify new targets for therapy.
Neoplasia (New York, N.Y.) 2005;7(12):1065-72.
2005: Monique B Nilsson; Robert R Langley; Isaiah J Fidler
Interleukin-6, secreted by human ovarian carcinoma cells, is a potent proangiogenic cytokine.
Cancer research 2005;65(23):10794-800.
2005: Kenji Yokoi; Takamitsu Sasaki; Corazon D Bucana; Dominic Fan; Cheryl H Baker; Yasuhiko Kitadai; Toshio Kuwai; James L Abbruzzese; Isaiah J Fidler
Simultaneous inhibition of EGFR, VEGFR, and platelet-derived growth factor receptor signaling combined with gemcitabine produces therapy of human pancreatic carcinoma and prolongs survival in an orthotopic nude mouse model.
Cancer research 2005;65(22):10371-80.
2005: Kenji Yokoi; Li-Chen Nancy Shih; Ryuji Kobayashi; John M Koomen; David Hawke; Donghui Li; Stanley R Hamilton; James L Abbruzzese; Kevin R Coombes; Isaiah J Fidler
Serum amyloid A as a tumor marker in sera of nude mice with orthotopic human pancreatic cancer and in plasma of patients with pancreatic cancer.
International journal of oncology 2005;27(5):1361-9.
2005: Sertac Yazici; Sun J Kim; J Erik Busby; Junqin He; Premal H Thaker; Kenji Yokoi; Dominic Fan; Isaiah J Fidler
Dual inhibition of the epidermal growth factor and vascular endothelial growth factor phosphorylation for antivascular therapy of human prostate cancer in the prostate of nude mice.
The Prostate 2005;65(3):203-15.
2005: Ronald Hoekstra; Herlinde Dumez; Ferry A L M Eskens; Ate van der Gaast; A S T Planting; Gerda de Heus; Kurt C Sizer; Christina Ravera; Sujata Vaidyanathan; Corazon D Bucana; Isaiah J Fidler; Allan T van Oosterom; Jaap Verweij
Phase I and pharmacologic study of PKI166, an epidermal growth factor receptor tyrosine kinase inhibitor, in patients with advanced solid malignancies.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(19 Pt 1):6908-15.
2005: Isaiah J Fidler
Cancer biology is the foundation for therapy.
Cancer biology & therapy 2005;4(9):1036-9.
2005: Kenji Yokoi; Sun-Jin Kim; Premal H Thaker; Sertac Yazici; Do-Hyun Nam; Junqin He; Takamitsu Sasaki; Paul J Chiao; Guido M Sclabas; James L Abbruzzese; Stanley R Hamilton; Isaiah J Fidler
Induction of apoptosis in tumor-associated endothelial cells and therapy of orthotopic human pancreatic carcinoma in nude mice.
Neoplasia (New York, N.Y.) 2005;7(7):696-704.
2005: Premal H Thaker; Sertac Yazici; Monique B Nilsson; Kenji Yokoi; Rachel Tsan; Junqin He; Sun-Jin Kim; Isaiah J Fidler; Anil K Sood
Antivascular therapy for orthotopic human ovarian carcinoma through blockade of the vascular endothelial growth factor and epidermal growth factor receptors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(13):4923-33.
2005: Hisanori Uehara; Patricia Troncoso; Dennis Johnston; Corazon D Bucana; Colin P N Dinney; Zhongyun Dong; Isaiah J Fidler; Curtis A Pettaway
Expression of interleukin-8 gene in radical prostatectomy specimens is associated with advanced pathologic stage.
The Prostate 2005;64(1):40-9.
2005: Maher N Younes; Orhan G Yigitbasi; Young Wook Park; Sun-Jin Kim; Samar A Jasser; Valerie Stone Hawthorne; Yasemin D Yazici; Mahitosh Mandal; B Nebiyou Bekele; Corazon D Bucana; Isaiah J Fidler; Jeffrey N Myers
Antivascular therapy of human follicular thyroid cancer experimental bone metastasis by blockade of epidermal growth factor receptor and vascular growth factor receptor phosphorylation.
Cancer research 2005;65(11):4716-27.
2005: Kenji Yokoi; Premal H Thaker; Sertac Yazici; robert rebhun; Do-Hyun Nam; Junqin He; Sun-Jin Kim; James L Abbruzzese; Stanley R Hamilton; Isaiah J Fidler
Dual inhibition of epidermal growth factor receptor and vascular endothelial growth factor receptor phosphorylation by AEE788 reduces growth and metastasis of human colon carcinoma in an orthotopic nude mouse model.
Cancer research 2005;65(9):3716-25.
2005: Sun-Jin Kim; Hisanori Uehara; Sertac Yazici; Junqin He; Robert R Langley; Paul Mathew; Dominic Fan; Isaiah J Fidler
Modulation of bone microenvironment with zoledronate enhances the therapeutic effects of STI571 and paclitaxel against experimental bone metastasis of human prostate cancer.
Cancer research 2005;65(9):3707-15.
2005: John M Koomen; Lichen Nancy Shih; Kevin R Coombes; Donghui Li; Lian-chun Xiao; Isaiah J Fidler; James L Abbruzzese; Ryuji Kobayashi
Plasma protein profiling for diagnosis of pancreatic cancer reveals the presence of host response proteins.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(3):1110-8.
2005: Guido M Sclabas; Shuichi Fujioka; Christian Schmidt; Zhongkui Li; WAYNE FREDERICK; Wentao Yang; Kenji Yokoi; Douglas B Evans; James L Abbruzzese; Kenneth R Hess; Wei Zhang; Isaiah J Fidler; Paul J Chiao
Overexpression of tropomysin-related kinase B in metastatic human pancreatic cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(2 Pt 1):440-9.
2005: Dina lev; Sun Jin Kim; Amir Onn; Valerie Stone; Do-Hyun Nam; Sertac Yazici; Isaiah J Fidler; Janet E Price
Inhibition of platelet-derived growth factor receptor signaling restricts the growth of human breast cancer in the bone of nude mice.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(1):306-14.
2005: Hua Cheng; Carlo Cenciarelli; Gina M Nelkin; Rachel Tsan; Dominic Fan; Cecilia Cheng-Mayer; Isaiah J Fidler
Molecular mechanism of hTid-1, the human homolog of Drosophila tumor suppressor l(2)Tid, in the regulation of NF-kappaB activity and suppression of tumor growth.
Molecular and cellular biology 2005;25(1):44-59.
2004: Amir Onn; Takeshi Isobe; Wenjuan Wu; Satoshi Itasaka; Tomoaki Shintani; Keiko Shibuya; Yokoi Kenji; Michael S O'Reilly; Isaiah J Fidler; Roy S Herbst
Epidermal growth factor receptor tyrosine kinase inhibitor does not improve paclitaxel effect in an orthotopic mouse model of lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(24):8613-9.
2004: Orhan G Yigitbasi; Maher N Younes; Dao Doan; Samar A Jasser; Bradley Schiff; Corazon D Bucana; B Nebiyou Bekele; Isaiah J Fidler; Jeffrey N Myers
Tumor cell and endothelial cell therapy of oral cancer by dual tyrosine kinase receptor blockade.
Cancer research 2004;64(21):7977-84.
2004: Paul Mathew; Peter F Thall; Donnah Jones; Cherie Perez; Corazon D Bucana; Patricia Troncoso; Sun-Jin Kim; Isaiah J Fidler; Christopher Logothetis
Platelet-derived growth factor receptor inhibitor imatinib mesylate and docetaxel: a modular phase I trial in androgen-independent prostate cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2004;22(16):3323-9.
2004: Isaiah J Fidler; Lee M Ellis
Neoplastic angiogenesis--not all blood vessels are created equal.
The New England journal of medicine 2004;351(3):215-6.
2004: Sun Jin Kim; Hisanori Uehara; Sertac Yazici; Robert R Langley; Junqin He; Rachel Tsan; Dominic Fan; Jerald J Killion; Isaiah J Fidler
Simultaneous blockade of platelet-derived growth factor-receptor and epidermal growth factor-receptor signaling and systemic administration of paclitaxel as therapy for human prostate cancer metastasis in bone of nude mice.
Cancer research 2004;64(12):4201-8.
2004: Robert R Langley; Dominic Fan; Rachel Tsan; robert rebhun; Junqin He; Sun-Jin Kim; Isaiah J Fidler
Activation of the platelet-derived growth factor-receptor enhances survival of murine bone endothelial cells.
Cancer research 2004;64(11):3727-30.
2004: Paul Mathew; Isaiah J Fidler; Christopher J Logothetis
Combination docetaxel and platelet-derived growth factor receptor inhibition with imatinib mesylate in prostate cancer.
Seminars in oncology 2004;31(2 Suppl 6):24-9.
2004: Kenji Yokoi; Isaiah J Fidler
Hypoxia increases resistance of human pancreatic cancer cells to apoptosis induced by gemcitabine.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(7):2299-306.
2004: Sachin M Apte; Corazon D Bucana; Jerald J Killion; David M Gershenson; Isaiah J Fidler
Expression of platelet-derived growth factor and activated receptor in clinical specimens of epithelial ovarian cancer and ovarian carcinoma cell lines.
Gynecologic oncology 2004;93(1):78-86.
2004: Sachin M Apte; Dominic Fan; Jerald J Killion; Isaiah J Fidler
Targeting the platelet-derived growth factor receptor in antivascular therapy for human ovarian carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(3):897-908.
2004: Isaiah J Fidler
From here to there; a life based on migration. An interview with Isaiah J. Fidler.
The International journal of developmental biology 2004;48(5-6):457-62.
2004: Amir Onn; Arlene M Correa; Michael Z Gilcrease; Takeshi Isobe; Erminia Massarelli; Corazon D Bucana; Michael S O'Reilly; Waun Ki Hong; Isaiah J Fidler; Joe B Putnam; Roy S Herbst
Synchronous overexpression of epidermal growth factor receptor and HER2-neu protein is a predictor of poor outcome in patients with stage I non-small cell lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(1 Pt 1):136-43.
2004: Corazon D Bucana; Isaiah J Fidler
Bioassay using epidermal keratinocytes to determine phosphorylation status of the epidermal growth factor receptor in distant neoplasms.
International journal of oncology 2004;24(1):19-24.
2003: Rosa F Hwang; Kenji Yokoi; Corazon D Bucana; Rachel Tsan; Jerald J Killion; Douglas B Evans; Isaiah J Fidler
Inhibition of platelet-derived growth factor receptor phosphorylation by STI571 (Gleevec) reduces growth and metastasis of human pancreatic carcinoma in an orthotopic nude mouse model.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(17):6534-44.
2003: Amir Onn; Takeshi Isobe; Satoshi Itasaka; Wenjuan Wu; Michael S O'Reilly; Waun Ki Hong; Isaiah J Fidler; Roy S Herbst
Development of an orthotopic model to study the biology and therapy of primary human lung cancer in nude mice.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(15):5532-9.
2003: Hiroki Kuniyasu; Hitoshi Ohmori; Takamistu Sasaki; Tomonori Sasahira; Kazuhiro Yoshida; Yasuhiko Kitadai; Isaiah J Fidler
Production of interleukin 15 by human colon cancer cells is associated with induction of mucosal hyperplasia, angiogenesis, and metastasis.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(13):4802-10.
2003: F Christopher Holsinger; Dao Doan; Samar A Jasser; Eric A Swan; Jayson S Greenberg; Bradley Schiff; B Nebiyou Bekele; Maher N Younes; Corazon D Bucana; Isaiah J Fidler; Jeffrey N Myers
Epidermal growth factor receptor blockade potentiates apoptosis mediated by Paclitaxel and leads to prolonged survival in a murine model of oral cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(8):3183-9.
2003: Marya F McCarty; Diane R Bielenberg; M B Nilsson; jeffrey gershenwald; R L Barnhill; P Ahearne; Corazon D Bucana; Isaiah J Fidler
Epidermal hyperplasia overlying human melanoma correlates with tumour depth and angiogenesis.
Melanoma research 2003;13(4):379-87.
2003: Hiroki Kuniyasu; Rinzo Ukai; Dennis Johnston; Patricia Troncoso; Isaiah J Fidler; Curtis A Pettaway
The relative mRNA expression levels of matrix metalloproteinase to E-cadherin in prostate biopsy specimens distinguishes organ-confined from advanced prostate cancer at radical prostatectomy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(6):2185-94.
2003: Robert R Langley; Karen M Ramirez; Rachel Tsan; Melissa Van Arsdall; Monique B Nilsson; Isaiah J Fidler
Tissue-specific microvascular endothelial cell lines from H-2K(b)-tsA58 mice for studies of angiogenesis and metastasis.
Cancer research 2003;63(11):2971-6.
2003: Kristin L Weber; Michele Doucet; Janet E Price; Cheryl Baker; Sun Jin Kim; Isaiah J Fidler
Blockade of epidermal growth factor receptor signaling leads to inhibition of renal cell carcinoma growth in the bone of nude mice.
Cancer research 2003;63(11):2940-7.
2003: Isaiah J Fidler
The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited.
Nature reviews. Cancer 2003;3(6):453-8.
2003: Isaiah J Fidler
Understanding bone metastases: the key to the effective treatment of prostate cancer.
Clinical advances in hematology & oncology : H&O 2003;1(5):278-9.
2003: Carmen C Solorzano; Rosa F Hwang; Cheryl H Baker; Corazon D Bucana; Peter W T Pisters; Douglas B Evans; Jerald J Killion; Isaiah J Fidler
Administration of optimal biological dose and schedule of interferon alpha combined with gemcitabine induces apoptosis in tumor-associated endothelial cells and reduces growth of human pancreatic carcinoma implanted orthotopically in nude mice.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(5):1858-67.
2003: Isaiah J Fidler; Margaret L Kripke
Genomic analysis of primary tumors does not address the prevalence of metastatic cells in the population.
Nature genetics 2003;34(1):23; author reply 25.
2003: Shutaro Ozawa; Weixin Lu; Corazon D Bucana; Hiro-Omi Kanayama; Hisashi Shinohara; Isaiah J Fidler; Zhongyun Dong
Regression of primary murine colon cancer and occult liver metastasis by intralesional injection of lyophilized preparation of insect cells producing murine interferon-beta.
International journal of oncology 2003;22(5):977-84.
2003: Hisanori Uehara; Sun Jin Kim; Takashi Karashima; David L Shepherd; Dominic Fan; Rachel Tsan; Jerald J Killion; Christopher Logothetis; Paul Mathew; Isaiah J Fidler
Effects of blocking platelet-derived growth factor-receptor signaling in a mouse model of experimental prostate cancer bone metastases.
Journal of the National Cancer Institute 2003;95(6):458-70.
2003: Weixin Lu; Jindong Su; Lee Su Kim; Corazon D Bucana; Cherrie Donawho; Junqing He; Isaiah J Fidler; Zhongyun Dong
Active specific immunotherapy against occult brain metastasis.
Cancer research 2003;63(6):1345-50.
2003: Sun-Jin Kim; Hisanori Uehara; Takashi Karashima; David L Shepherd; Jerald J Killion; Isaiah J Fidler
Blockade of epidermal growth factor receptor signaling in tumor cells and tumor-associated endothelial cells for therapy of androgen-independent human prostate cancer growing in the bone of nude mice.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(3):1200-10.
2003: Isaiah J Fidler; Junya Yoneda; Carlos Herrera; Jeanette Wood; Lei Xu
Specific keynote: molecular determinants of angiogenesis in ovarian cancer.
Gynecologic oncology 2003;88(1 Pt 2):S29-36; discussion S37-42.
2002: Isaiah J Fidler
The organ microenvironment and cancer metastasis.
Differentiation; research in biological diversity 2002;70(9-10):498-505.
2002: Amir Onn; Isaiah J Fidler
Metastatic potential of human neoplasms.
In vivo (Athens, Greece) 2002;16(6):423-9.
2002: Yutaka Takahashi; Yasuhiko Kitadai; Lee M Ellis; Corazon D Bucana; Isaiah J Fidler; Masayoshi Mai
Multiparametric in situ mRNA hybridization analysis of gastric biopsies predicts lymph node metastasis in patients with gastric carcinoma.
Japanese journal of cancer research : Gann 2002;93(11):1258-65.
2002: Daniel Kedar; Cheryl H Baker; Jerald J Killion; Colin P N Dinney; Isaiah J Fidler
Blockade of the epidermal growth factor receptor signaling inhibits angiogenesis leading to regression of human renal cell carcinoma growing orthotopically in nude mice.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(11):3592-600.
2002: Eric C McGary; Kristin L Weber; Lisa D. Mills; Michelle Doucet; Valerie Lewis; Dina lev; Isaiah J Fidler; Menashe Bar-Eli
Inhibition of platelet-derived growth factor-mediated proliferation of osteosarcoma cells by the novel tyrosine kinase inhibitor STI571.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(11):3584-91.
2002: Samuel F Huang; Sun-Jin Kim; Anh T Lee; Takashi Karashima; Corazon D Bucana; Daniel Kedar; Paul Sweeney; Badar M Mian; Dominic Fan; David Shepherd; Isaiah J Fidler; Colin P N Dinney; Jerald J Killion
Inhibition of growth and metastasis of orthotopic human prostate cancer in athymic mice by combination therapy with pegylated interferon-alpha-2b and docetaxel.
Cancer research 2002;62(20):5720-6.
2002: Dominic Fan; Amy Liaw; Yvonne Denkins; James H Collins; Melissa Van Arsdall; Jolie Lien Chang; Subhas Chakrabarty; Dieuthu Nguyen; Ewa Kruzel; Isaiah J Fidler
Type-1 transforming growth factor-beta differentially modulates tumoricidal activity of murine peritoneal macrophages against metastatic variants of the B16 murine melanoma.
Journal of experimental therapeutics & oncology 2002;2(5):286-97.
2002: Cheryl H Baker; Daniel Kedar; Marya F McCarty; Rachel Tsan; Kristin L Weber; Corazon D Bucana; Isaiah J Fidler
Blockade of epidermal growth factor receptor signaling on tumor cells and tumor-associated endothelial cells for therapy of human carcinomas.
The American journal of pathology 2002;161(3):929-38.
2002: Suyun Huang; Melissa Van Arsdall; Sean Tedjarati; Marya McCarty; Wenjuan Wu; Robert Langley; Isaiah J Fidler
Contributions of stromal metalloproteinase-9 to angiogenesis and growth of human ovarian carcinoma in mice.
Journal of the National Cancer Institute 2002;94(15):1134-42.
2002: Jeffrey N Myers; F Christopher Holsinger; B Nebiyou Bekele; Emily Li; Samar A Jasser; Jerald J Killion; Isaiah J Fidler
Targeted molecular therapy for oral cancer with epidermal growth factor receptor blockade: a preliminary report.
Archives of otolaryngology--head & neck surgery 2002;128(8):875-9.
2002: Weixin Lu; Zhongyun Dong; Cherrie Donawho; Isaiah J Fidler
Specific immunotherapy against occult cancer metastases.
International journal of cancer. Journal international du cancer 2002;100(4):480-5.
2002: Sean Tedjarati; Cheryl H Baker; Sachin Apte; Suyun Huang; Judith K Wolf; Jerald J Killion; Isaiah J Fidler
Synergistic therapy of human ovarian carcinoma implanted orthotopically in nude mice by optimal biological dose of pegylated interferon alpha combined with paclitaxel.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(7):2413-22.
2002: Matus Studeny; Frank C Marini; Richard E Champlin; Claudia Zompetta; Isaiah J Fidler; Michael Andreeff
Bone marrow-derived mesenchymal stem cells as vehicles for interferon-beta delivery into tumors.
Cancer research 2002;62(13):3603-8.
2002: Marya F McCarty; Cheryl H Baker; Corazon D Bucana; Isaiah J Fidler
Quantitative and qualitative in vivo angiogenesis assay.
International journal of oncology 2002;21(1):5-10.
2002: jeffrey gershenwald; Isaiah J Fidler
Cancer. Targeting lymphatic metastasis.
Science (New York, N.Y.) 2002;296(5574):1811-2.
2002: Dominic Fan; Seiji Yano; Hisashi Shinohara; Carmen C Solorzano; Melissa Van Arsdall; Corazon D Bucana; Sen Pathak; Ewa Kruzel; Roy S Herbst; Amir Onn; Jennifer S Roach; Masanori Onda; Qing-Cheng Wang; Ira Pastan; Isaiah J Fidler
Targeted therapy against human lung cancer in nude mice by high-affinity recombinant antimesothelin single-chain Fv immunotoxin.
Molecular cancer therapeutics 2002;1(8):595-600.
2002: Suyun Huang; Corazon D Bucana; Melissa Van Arsdall; Isaiah J Fidler
Stat1 negatively regulates angiogenesis, tumorigenicity and metastasis of tumor cells.
Oncogene 2002;21(16):2504-12.
2002: Isaiah J Fidler
Critical determinants of metastasis.
Seminars in cancer biology 2002;12(2):89-96.
2002: Cheryl H Baker; Carmen C Solorzano; Isaiah J Fidler
Blockade of vascular endothelial growth factor receptor and epidermal growth factor receptor signaling for therapy of metastatic human pancreatic cancer.
Cancer research 2002;62(7):1996-2003.
2002: Marya F McCarty; Diane R Bielenberg; Cherrie Donawho; Corazon D Bucana; Isaiah J Fidler
Evidence for the causal role of endogenous interferon-alpha/beta in the regulation of angiogenesis, tumorigenicity, and metastasis of cutaneous neoplasms.
Clinical & experimental metastasis 2002;19(7):609-15.
2002: Isaiah J Fidler; Seiji Yano; Ruo-Dan Zhang; Takahashi Fujimaki; Corazon D Bucana
The seed and soil hypothesis: vascularisation and brain metastases.
The lancet oncology 2002;3(1):53-7.
2002: Jeffrey N Myers; F Christopher Holsinger; Samar A Jasser; B Nebiyou Bekele; Isaiah J Fidler
An orthotopic nude mouse model of oral tongue squamous cell carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(1):293-8.
2002: Carlos A Herrera; Lei Xu; Corazon D Bucana; El Vio G Silva; Kenneth R Hess; David M Gershenson; Isaiah J Fidler
Expression of metastasis-related genes in human epithelial ovarian tumors.
International journal of oncology 2002;20(1):5-13.
2001: Carmen C Solorzano; Cheryl H Baker; Christiane J Bruns; Jerald J Killion; Lee M Ellis; J Wood; Isaiah J Fidler
Inhibition of growth and metastasis of human pancreatic cancer growing in nude mice by PTK 787/ZK222584, an inhibitor of the vascular endothelial growth factor receptor tyrosine kinases.
Cancer biotherapy & radiopharmaceuticals 2001;16(5):359-70.
2001: H Kuniyasu; James L Abbruzzese; Karen R Cleary; Isaiah J Fidler
Induction of ductal and stromal hyperplasia by basic fibroblast growth factor produced by human pancreatic carcinoma.
International journal of oncology 2001;19(4):681-5.
2001: H Kuniyasu; W Yasui; Curtis A Pettaway; S Yano; N Oue; E Tahara; Isaiah J Fidler
Interferon-alpha prevents selection of doxorubicin-resistant undifferentiated-androgen-insensitive metastatic human prostate cancer cells.
The Prostate 2001;49(1):19-29.
2001: Carmen C Solorzano; Cheryl H Baker; Rachel Tsan; Peter Traxler; Pinchas Cohen; Elisabeth Buchdunger; Jerald J Killion; Isaiah J Fidler
Optimization for the blockade of epidermal growth factor receptor signaling for therapy of human pancreatic carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(8):2563-72.
2001: Suyun Huang; C A Pettaway; H Uehara; Corazon D Bucana; Isaiah J Fidler
Blockade of NF-kappaB activity in human prostate cancer cells is associated with suppression of angiogenesis, invasion, and metastasis.
Oncogene 2001;20(31):4188-97.
2001: Cheryl H Baker; Carmen C Solorzano; Isaiah J Fidler
Angiogenesis and cancer metastasis: antiangiogenic therapy of human pancreatic adenocarcinoma.
International journal of clinical oncology 2001;6(2):59-65.
2001: S Ozawa; H Shinohara; Hiro-Omi Kanayama; Christiane J Bruns; Corazon D Bucana; Lee M Ellis; Darren W Davis; Isaiah J Fidler
Suppression of angiogenesis and therapy of human colon cancer liver metastasis by systemic administration of interferon-alpha.
Neoplasia (New York, N.Y.) 2001;3(2):154-64.
2001: Joel W Slaton; K Inoue; Paul Perrotte; Adel K El-Naggar; David A Swanson; Isaiah J Fidler; C P Dinney
Expression levels of genes that regulate metastasis and angiogenesis correlate with advanced pathological stage of renal cell carcinoma.
The American journal of pathology 2001;158(2):735-43.
2001: Sun-Jin Kim; H Uehara; T Karashima; Marya McCarty; N Shih; Isaiah J Fidler
Expression of interleukin-8 correlates with angiogenesis, tumorigenicity, and metastasis of human prostate cancer cells implanted orthotopically in nude mice.
Neoplasia (New York, N.Y.) 2001;3(1):33-42.
2001: Isaiah J Fidler
Regulation of neoplastic angiogenesis.
Journal of the National Cancer Institute. Monographs 2001;(28):10-4.
2000: S Yano; H Shinohara; R S Herbst; H Kuniyasu; Corazon D Bucana; Lee M Ellis; Isaiah J Fidler
Production of experimental malignant pleural effusions is dependent on invasion of the pleura and expression of vascular endothelial growth factor/vascular permeability factor by human lung cancer cells.
The American journal of pathology 2000;157(6):1893-903.
2000: H Kuniyasu; W Yasui; H Shinohara; S Yano; Lee M Ellis; M R Wilson; Corazon D Bucana; T Rikita; E Tahara; Isaiah J Fidler
Induction of angiogenesis by hyperplastic colonic mucosa adjacent to colon cancer.
The American journal of pathology 2000;157(5):1523-35.
2000: Suyun Huang; Jubilee B Robinson; A DeGuzman; Corazon D Bucana; Isaiah J Fidler
Blockade of nuclear factor-kappaB signaling inhibits angiogenesis and tumorigenicity of human ovarian cancer cells by suppressing expression of vascular endothelial growth factor and interleukin 8.
Cancer research 2000;60(19):5334-9.
2000: Hisashi Shinohara; Dominic Fan; S Ozawa; Seiji Yano; M Van Arsdell; Jaye L Viner; Richard Beers; Ira Pastan; Isaiah J Fidler
Site-specific expression of transferrin receptor by human colon cancer cells directly correlates with eradication by antitransferrin recombinant immunotoxin.
International journal of oncology 2000;17(4):643-51.
2000: S Yano; H Shinohara; Roy S Herbst; H Kuniyasu; Corazon D Bucana; Lee M Ellis; Darren W Davis; David J McConkey; Isaiah J Fidler
Expression of vascular endothelial growth factor is necessary but not sufficient for production and growth of brain metastasis.
Cancer research 2000;60(17):4959-67.
2000: L Xu; Isaiah J Fidler
Acidic pH-induced elevation in interleukin 8 expression by human ovarian carcinoma cells.
Cancer research 2000;60(16):4610-6.
2000: Suyun Huang; A DeGuzman; Corazon D Bucana; Isaiah J Fidler
Nuclear factor-kappaB activity correlates with growth, angiogenesis, and metastasis of human melanoma cells in nude mice.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(6):2573-81.
2000: H Kuniyasu; Patricia Troncoso; D Johnston; Corazon D Bucana; E Tahara; Isaiah J Fidler; Curtis A Pettaway
Relative expression of type IV collagenase, E-cadherin, and vascular endothelial growth factor/vascular permeability factor in prostatectomy specimens distinguishes organ-confined from pathologically advanced prostate cancers.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(6):2295-308.
2000: Christiane J Bruns; Carmen C Solorzano; Matthew T Harbison; S Ozawa; Rachel Tsan; Dominic Fan; James L Abbruzzese; Peter Traxler; Elisabeth Buchdunger; Robert Radinsky; Isaiah J Fidler
Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma.
Cancer research 2000;60(11):2926-35.
2000: Rakesh Kumar; Keping Xie; I Eue; Zhongyun Dong; Jerald J Killion; Isaiah J Fidler
Differential regulation of type IV collagenases and metalloelastase in murine macrophages by the synthetic bacterial lipopeptide JBT 3002.
International journal of immunopharmacology 2000;22(6):431-43.
2000: Isaiah J Fidler; R K Singh; Junya Yoneda; Rakesh Kumar; Lei Xu; Zhongyun Dong; Diane R Bielenberg; Marya McCarty; Lee M Ellis
Critical determinants of neoplastic angiogenesis.
Cancer journal (Sudbury, Mass.) 2000;6 Suppl 3():S225-36.
2000: H Shinohara; Corazon D Bucana; Jerald J Killion; Isaiah J Fidler
Intensified regression of colon cancer liver metastases in mice treated with irinotecan and the immunomodulator JBT 3002.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2000;23(3):321-31.
2000: Isaiah J Fidler
Angiogenesis and cancer metastasis.
Cancer journal (Sudbury, Mass.) 2000;6 Suppl 2():S134-41.
2000: Suyun Huang; A DeGuzman; Corazon D Bucana; Isaiah J Fidler
Level of interleukin-8 expression by metastatic human melanoma cells directly correlates with constitutive NF-kappaB activity.
Cytokines, cellular & molecular therapy 2000;6(1):9-17.
2000: S Yano; Roy S Herbst; H Shinohara; B Knighton; Corazon D Bucana; Jerald J Killion; J Wood; Isaiah J Fidler
Treatment for malignant pleural effusion of human lung adenocarcinoma by inhibition of vascular endothelial growth factor receptor tyrosine kinase phosphorylation.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(3):957-65.
2000: Roy S Herbst; S Yano; H Kuniyasu; Fadlo R Khuri; Corazon D Bucana; F Guo; Diane Liu; B Kemp; J Jack Lee; Waun Ki Hong; Isaiah J Fidler
Differential expression of E-cadherin and type IV collagenase genes predicts outcome in patients with stage I non-small cell lung carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(3):790-7.
2000: Jianhua Yang; M Boerm; Marya McCarty; C Bucana; Isaiah J Fidler; Y Zhuang; Bing Su
Mekk3 is essential for early embryonic cardiovascular development.
Nature genetics 2000;24(3):309-13.
2000: H Shinohara; S Yano; Corazon D Bucana; Isaiah J Fidler
Induction of chemokine secretion and enhancement of contact-dependent macrophage cytotoxicity by engineered expression of granulocyte-macrophage colony-stimulating factor in human colon cancer cells.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(5):2728-37.
2000: Lei Xu; Junya Yoneda; C Herrera; J Wood; Jerald J Killion; Isaiah J Fidler
Inhibition of malignant ascites and growth of human ovarian carcinoma by oral administration of a potent inhibitor of the vascular endothelial growth factor receptor tyrosine kinases.
International journal of oncology 2000;16(3):445-54.
2000: Christiane J Bruns; H Shinohara; Matthew T Harbison; Darren W Davis; Gina M Nelkin; Jerald J Killion; David J McConkey; Zhongyun Dong; Isaiah J Fidler
Therapy of human pancreatic carcinoma implants by irinotecan and the oral immunomodulator JBT 3002 is associated with enhanced expression of inducible nitric oxide synthase in tumor-infiltrating macrophages.
Cancer research 2000;60(1):2-7.
1999: L Xu; Keping Xie; N Mukaida; K Matsushima; Isaiah J Fidler
Hypoxia-induced elevation in interleukin-8 expression by human ovarian carcinoma cells.
Cancer research 1999;59(22):5822-9.
1999: Qiuling Shi; James L Abbruzzese; Suyun Huang; Isaiah J Fidler; Q Xiong; Keping Xie
Constitutive and inducible interleukin 8 expression by hypoxia and acidosis renders human pancreatic cancer cells more tumorigenic and metastatic.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(11):3711-21.
1999: Weixin Lu; Isaiah J Fidler; Zhongyun Dong
Eradication of primary murine fibrosarcomas and induction of systemic immunity by adenovirus-mediated interferon beta gene therapy.
Cancer research 1999;59(20):5202-8.
1999: Joel W Slaton; Paul Perrotte; Keji Inoue; Colin P N Dinney; Isaiah J Fidler
Interferon-alpha-mediated down-regulation of angiogenesis-related genes and therapy of bladder cancer are dependent on optimization of biological dose and schedule.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(10):2726-34.
1999: Asha S Multani; M Ozen; S Sen; A K Mandal; Janet E Price; Dominic Fan; Robert Radinsky; Francis Ali-Osman; Andrew C von Eschenbach; Isaiah J Fidler; Sen Pathak
Amplification of telomeric DNA directly correlates with metastatic potential of human and murine cancers of various histological origin.
International journal of oncology 1999;15(3):423-9.
1999: H Shinohara; Jerald J Killion; Corazon D Bucana; S Yano; Isaiah J Fidler
Oral administration of the immunomodulator JBT-3002 induces endogenous interleukin 15 in intestinal macrophages for protection against irinotecan-mediated destruction of intestinal epithelium.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(8):2148-56.
1999: Junya Yoneda; Jerald J Killion; Corazon D Bucana; Isaiah J Fidler
Angiogenesis and growth of murine colon carcinoma are dependent on infiltrating leukocytes.
Cancer biotherapy & radiopharmaceuticals 1999;14(3):221-30.
1999: Diane R Bielenberg; Marya F McCarty; Corazon D Bucana; Stuart H Yuspa; D Morgan; J M Arbeit; Lee M Ellis; Karen R Cleary; Isaiah J Fidler
Expression of interferon-beta is associated with growth arrest of murine and human epidermal cells.
The Journal of investigative dermatology 1999;112(5):802-9.
1999: Christiane J Bruns; Matthew T Harbison; H Kuniyasu; I Eue; Isaiah J Fidler
In vivo selection and characterization of metastatic variants from human pancreatic adenocarcinoma by using orthotopic implantation in nude mice.
Neoplasia (New York, N.Y.) 1999;1(1):50-62.
1999: MD Balbay; Curtis A Pettaway; H Kuniyasu; Keji Inoue; E Ramirez; E Li; Isaiah J Fidler; Colin P N Dinney
Highly metastatic human prostate cancer growing within the prostate of athymic mice overexpresses vascular endothelial growth factor.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(4):783-9.
1999: Diane R Bielenberg; Corazon D Bucana; R Sanchez; J B Mulliken; Judah Folkman; Isaiah J Fidler
Progressive growth of infantile cutaneous hemangiomas is directly correlated with hyperplasia and angiogenesis of adjacent epidermis and inversely correlated with expression of the endogenous angiogenesis inhibitor, IFN-beta.
International journal of oncology 1999;14(3):401-8.
1999: Zhongyun Dong; G Greene; Curtis A Pettaway; Colin P N Dinney; I Eue; Weixin Lu; Corazon D Bucana; MD Balbay; Diane R Bielenberg; Isaiah J Fidler
Suppression of angiogenesis, tumorigenicity, and metastasis by human prostate cancer cells engineered to produce interferon-beta.
Cancer research 1999;59(4):872-9.
1999: H Kanayama; S Yano; S J Kim; S Ozawa; Lee M Ellis; Isaiah J Fidler
Expression of vascular endothelial growth factor by human renal cancer cells enhances angiogenesis of primary tumors and production of ascites but not metastasis to the lungs in nude mice.
Clinical & experimental metastasis 1999;17(10):831-40.
1999: Isaiah J Fidler; G Schackert; Ruo-Dan Zhang; Robert Radinsky; T Fujimaki
The biology of melanoma brain metastasis.
Cancer metastasis reviews 1999;18(3):387-400.
1999: H Kuniyasu; Lee M Ellis; Douglas B Evans; James L Abbruzzese; CJ Fenoglio; Corazon D Bucana; Karen R Cleary; E Tahara; Isaiah J Fidler
Relative expression of E-cadherin and type IV collagenase genes predicts disease outcome in patients with resectable pancreatic carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(1):25-33.
1999: Rakesh Kumar; Junya Yoneda; Isaiah J Fidler; Zhongyun Dong
GM-CSF-transduced B16 melanoma cells are highly susceptible to lysis by normal murine macrophages and poorly tumorigenic in immune-compromised mice.
Journal of leukocyte biology 1999;65(1):102-8.
1998: Lei Xu; Keping Xie; Isaiah J Fidler
Therapy of human ovarian cancer by transfection with the murine interferon beta gene: role of macrophage-inducible nitric oxide synthase.
Human gene therapy 1998;9(18):2699-708.
1998: Diane R Bielenberg; Corazon D Bucana; R Sanchez; Cherrie Donawho; Margaret L Kripke; Isaiah J Fidler
Molecular regulation of UVB-induced cutaneous angiogenesis.
The Journal of investigative dermatology 1998;111(5):864-72.
1998: Diane R Bielenberg; Isaiah J Fidler; Corazon D Bucana
Constitutive expression of interferon beta in differentiated epithelial cells exposed to environmental stimuli.
Cancer biotherapy & radiopharmaceuticals 1998;13(5):375-82.
1998: I Eue; Rakesh Kumar; Zhongyun Dong; Jerald J Killion; Isaiah J Fidler
Induction of nitric oxide production and tumoricidal properties in murine macrophages by a new synthetic lipopeptide JBT3002 encapsulated in liposomes.
Journal of immunotherapy (Hagerstown, Md. : 1997) 1998;21(5):340-51.
1998: H Shinohara; Jerald J Killion; H Kuniyasu; Rakesh Kumar; Isaiah J Fidler
Prevention of intestinal toxic effects and intensification of irinotecan's therapeutic efficacy against murine colon cancer liver metastases by oral administration of the lipopeptide JBT 3002.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(9):2053-63.
1998: Zhongyun Dong; Junya Yoneda; Rakesh Kumar; Isaiah J Fidler
Angiostatin-mediated suppression of cancer metastases by primary neoplasms engineered to produce granulocyte/macrophage colony-stimulating factor.
The Journal of experimental medicine 1998;188(4):755-63.
1998: Zhongyun Dong; Jerald J Killion; Rakesh Kumar; I Eue; X Yang; Weixin Lu; B Su; Isaiah J Fidler
Activation of cytokine production, tumoricidal properties, and tyrosine phosphorylation of MAPKs in human monocytes by a new synthetic lipopeptide, JBT3002.
Journal of leukocyte biology 1998;63(6):766-74.
1998: Zhongyun Dong; SH Juang; Rakesh Kumar; I Eue; Keping Xie; Diane R Bielenberg; Weixin Lu; Corazon D Bucana; X Yang; Isaiah J Fidler
Suppression of tumorigenicity and metastasis in murine UV-2237 fibrosarcoma cells by infection with a retroviral vector harboring the interferon-beta gene.
Cancer immunology, immunotherapy : CII 1998;46(3):137-46.
1998: Isaiah J Fidler; Rakesh Kumar; Diane R Bielenberg; Lee M Ellis
Molecular determinants of angiogenesis in cancer metastasis.
The cancer journal from Scientific American 1998;4 Suppl 1():S58-66.
1998: SH Juang; Keping Xie; Lei Xu; Q Shi; Y Wang; Junya Yoneda; Isaiah J Fidler
Suppression of tumorigenicity and metastasis of human renal carcinoma cells by infection with retroviral vectors harboring the murine inducible nitric oxide synthase gene.
Human gene therapy 1998;9(6):845-54.
1998: Rakesh Kumar; Junya Yoneda; Corazon D Bucana; Isaiah J Fidler
Regulation of distinct steps of angiogenesis by different angiogenic molecules.
International journal of oncology 1998;12(4):749-57.
1998: Junya Yoneda; H Kuniyasu; Marta Crispens; Janet E Price; Corazon D Bucana; Isaiah J Fidler
Expression of angiogenesis-related genes and progression of human ovarian carcinomas in nude mice.
Journal of the National Cancer Institute 1998;90(6):447-54.
1998: Keping Xie; Isaiah J Fidler
Therapy of cancer metastasis by activation of the inducible nitric oxide synthase.
Cancer metastasis reviews 1998;17(1):55-75.
1998: Colin P N Dinney; Diane R Bielenberg; Paul Perrotte; R Reich; Beryl Y Eve; Corazon D Bucana; Isaiah J Fidler
Inhibition of basic fibroblast growth factor expression, angiogenesis, and growth of human bladder carcinoma in mice by systemic interferon-alpha administration.
Cancer research 1998;58(4):808-14.
1998: Jerald J Killion; Robert Radinsky; Isaiah J Fidler
Orthotopic models are necessary to predict therapy of transplantable tumors in mice.
Cancer metastasis reviews 1998;17(3):279-84.
1998: R Kumar; H Kuniyasu; Corazon D Bucana; M R Wilson; Isaiah J Fidler
Spatial and temporal expression of angiogenic molecules during tumor growth and progression.
Oncology research 1998;10(6):301-11.
1998: Rakesh Kumar; Isaiah J Fidler
Angiogenic molecules and cancer metastasis.
In vivo (Athens, Greece) 1998;12(1):27-34.
1997: Keping Xie; Diane R Bielenberg; Suyun Huang; Lei Xu; Thomas R Salas; SH Juang; Zhongyun Dong; Isaiah J Fidler
Abrogation of tumorigenicity and metastasis of murine and human tumor cells by transfection with the murine IFN-beta gene: possible role of nitric oxide.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(12 Pt 1):2283-94.
1997: M A Nemeth; M R Wilson; Isaiah J Fidler; Sen Pathak
Increasing metastatic potential is associated with induced chromosome 14 translocations in a previously nonmetastatic murine melanoma cell line.
Cancer genetics and cytogenetics 1997;98(2):119-25.
1997: Rakesh Kumar; I Eue; Zhongyun Dong; Jerald J Killion; Isaiah J Fidler
Expression of inflammatory cytokines by murine macrophages activated with a new synthetic lipopeptide JT3002.
Cancer biotherapy & radiopharmaceuticals 1997;12(5):333-40.
1997: Keping Xie; Yunfei Wang; Suyun Huang; Lei Xu; Diane R Bielenberg; Thomas R Salas; David J McConkey; Wei Jiang; Isaiah J Fidler
Nitric oxide-mediated apoptosis of K-1735 melanoma cells is associated with downregulation of Bcl-2.
Oncogene 1997;15(7):771-9.
1997: S S Yoon; Isaiah J Fidler; PJ Beltran; Corazon D Bucana; Y F Wang; Dominic Fan
Intratumoral heterogeneity for and epigenetic modulation of mdr-1 expression in murine melanoma.
Melanoma research 1997;7(4):275-87.
1997: SH Juang; Keping Xie; Lei Xu; Y Wang; Junya Yoneda; Isaiah J Fidler
Use of retroviral vectors encoding murine inducible nitric oxide synthase gene to suppress tumorigenicity and cancer metastasis of murine melanoma.
Cancer biotherapy & radiopharmaceuticals 1997;12(3):167-75.
1997: GF Greene; Y Kitadai; C A Pettaway; Andrew C von Eschenbach; Corazon D Bucana; Isaiah J Fidler
Correlation of metastasis-related gene expression with metastatic potential in human prostate carcinoma cells implanted in nude mice using an in situ messenger RNA hybridization technique.
The American journal of pathology 1997;150(5):1571-82.
1997: Zhongyun Dong; Rakesh Kumar; X Yang; Isaiah J Fidler
Macrophage-derived metalloelastase is responsible for the generation of angiostatin in Lewis lung carcinoma.
Cell 1997;88(6):801-10.
1997: Keping Xie; Suyun Huang; Zhongyun Dong; SH Juang; Y Wang; Isaiah J Fidler
Destruction of bystander cells by tumor cells transfected with inducible nitric oxide (NO) synthase gene.
Journal of the National Cancer Institute 1997;89(6):421-7.
1997: PJ Beltran; Dominic Fan; Isaiah J Fidler; Catherine A O'Brian
Chemosensitization of cancer cells by the staurosporine derivative CGP 41251 in association with decreased P-glycoprotein phosphorylation.
Biochemical pharmacology 1997;53(2):245-7.
1996: Jerald J Killion; Corazon D Bucana; Robert Radinsky; Zhongyun Dong; Terence O'Reilly; G Bilbe; L Tarcsay; Isaiah J Fidler
Maintenance of intestinal epithelium structural integrity and mucosal leukocytes during chemotherapy by oral administration of muramyl tripeptide phosphatidylethanolamine.
Cancer biotherapy & radiopharmaceuticals 1996;11(6):363-71.
1996: Lee M Ellis; Isaiah J Fidler
Angiogenesis and metastasis.
European journal of cancer (Oxford, England : 1990) 1996;32A(14):2451-60.
1996: Rakesh Kumar; Zhongyun Dong; Isaiah J Fidler
Differential regulation of metalloelastase activity in murine peritoneal macrophages by granulocyte-macrophage colony-stimulating factor and macrophage colony-stimulating factor.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(11):5104-11.
1996: B J Dave; R Singh; Isaiah J Fidler; Sen Pathak
Chromosome 14 alteration is associated with increased collagenase expression and the metastatic potential of murine melanomas.
Cancer genetics and cytogenetics 1996;92(1):66-72.
1996: Y Kitadai; Lee M Ellis; S L Tucker; GF Greene; Corazon D Bucana; Karen R Cleary; Y Takahashi; E Tahara; Isaiah J Fidler
Multiparametric in situ mRNA hybridization analysis to predict disease recurrence in patients with colon carcinoma.
The American journal of pathology 1996;149(5):1541-51.
1996: Keping Xie; Suyun Huang; Y Wang; P J Beltran; SH Juang; Zhongyun Dong; J C Reed; Timothy J McDonnell; David J McConkey; Isaiah J Fidler
Bcl-2 protects cells from cytokine-induced nitric-oxide-dependent apoptosis.
Cancer immunology, immunotherapy : CII 1996;43(2):109-15.
1996: T Fujimaki; Janet E Price; Dominic Fan; Corazon D Bucana; K Itoh; T Kirino; Isaiah J Fidler
Selective growth of human melanoma cells in the brain parenchyma of nude mice.
Melanoma research 1996;6(5):363-71.
1996: Y Kitadai; Robert Radinsky; Corazon D Bucana; Y Takahashi; Keping Xie; E Tahara; Isaiah J Fidler
Regulation of carcinoembryonic antigen expression in human colon carcinoma cells by the organ microenvironment.
The American journal of pathology 1996;149(4):1157-66.
1996: Curtis A Pettaway; Sen Pathak; G Greene; E Ramirez; M R Wilson; Jerald J Killion; Isaiah J Fidler
Selection of highly metastatic variants of different human prostatic carcinomas using orthotopic implantation in nude mice.
Clinical cancer research : an official journal of the American Association for Cancer Research 1996;2(9):1627-36.
1996: R K Singh; M Gutman; N Llansa; Isaiah J Fidler
Interferon-beta prevents the upregulation of interleukin-8 expression in human melanoma cells.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1996;16(8):577-84.
1996: Keping Xie; Zhongyun Dong; Isaiah J Fidler
Activation of nitric oxide synthase gene for inhibition of cancer metastasis.
Journal of leukocyte biology 1996;59(6):797-803.
1996: H Anzai; Y Kitadai; Corazon D Bucana; R Sanchez; Ryozo Omoto; Isaiah J Fidler
Intratumoral heterogeneity and inverse correlation between expression of E-cadherin and collagenase type IV in human gastric carcinomas.
Differentiation; research in biological diversity 1996;60(2):119-27.
1996: Isaiah J Fidler
Critical determinants of melanoma metastasis.
The journal of investigative dermatology. Symposium proceedings / the Society for Investigative Dermatology, Inc. [and] European Society for Dermatological Research 1996;1(2):203-8.
1996: R K Singh; N Llansa; Corazon D Bucana; R Sanchez; A Koura; Isaiah J Fidler
Cell density-dependent regulation of basic fibroblast growth factor expression in human renal cell carcinoma cells.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1996;7(3):397-404.
1996: R K Singh; Isaiah J Fidler
Regulation of tumor angiogenesis by organ-specific cytokines.
Current topics in microbiology and immunology 1996;213 ( Pt 2)():1-11.
1996: Y Takahashi; Lee M Ellis; M R Wilson; Corazon D Bucana; Y Kitadai; Isaiah J Fidler
Progressive upregulation of metastasis-related genes in human colon cancer cells implanted into the cecum of nude mice.
Oncology research 1996;8(4):163-9.
1995: Zhongyun Dong; X Yang; Keping Xie; SH Juang; N Llansa; Isaiah J Fidler
Activation of inducible nitric oxide synthase gene in murine macrophages requires protein phosphatases 1 and 2A activities.
Journal of leukocyte biology 1995;58(6):725-32.
1995: Isaiah J Fidler
Modulation of the organ microenvironment for treatment of cancer metastasis.
Journal of the National Cancer Institute 1995;87(21):1588-92.
1995: Y Kitadai; Corazon D Bucana; Lee M Ellis; H Anzai; E Tahara; Isaiah J Fidler
In situ mRNA hybridization technique for analysis of metastasis-related genes in human colon carcinoma cells.
The American journal of pathology 1995;147(5):1238-47.
1995: Y Kitadai; Lee M Ellis; Y Takahashi; Corazon D Bucana; H Anzai; E Tahara; Isaiah J Fidler
Multiparametric in situ messenger RNA hybridization analysis to detect metastasis-related genes in surgical specimens of human colon carcinomas.
Clinical cancer research : an official journal of the American Association for Cancer Research 1995;1(10):1095-102.
1995: Colin P N Dinney; R Fishbeck; R K Singh; Beryl Y Eve; Sen Pathak; N Brown; B Xie; Dominic Fan; Corazon D Bucana; Isaiah J Fidler
Isolation and characterization of metastatic variants from human transitional cell carcinoma passaged by orthotopic implantation in athymic nude mice.
The Journal of urology 1995;154(4):1532-8.
1995: Keping Xie; Suyun Huang; Zhongyun Dong; M Gutman; Isaiah J Fidler
Direct correlation between expression of endogenous inducible nitric oxide synthase and regression of M5076 reticulum cell sarcoma hepatic metastases in mice treated with liposomes containing lipopeptide CGP 31362.
Cancer research 1995;55(14):3123-31.
1995: M Gutman; R K Singh; Keping Xie; Corazon D Bucana; Isaiah J Fidler
Regulation of interleukin-8 expression in human melanoma cells by the organ environment.
Cancer research 1995;55(11):2470-5.
1995: M Gutman; P J Beltran; Dominic Fan; M G Delworth; R K Singh; M R Wilson; Isaiah J Fidler
Treatment of nude mice with 4-amidinoindan -1- one2 '- amidinohydrazone, a new S-adenosylmethionine decarboxylase inhibitor, delays growth and inhibits metastasis of human melanoma cells.
Melanoma research 1995;5(3):147-54.
1995: Colin P N Dinney; S Tanguay; Corazon D Bucana; Beryl Y Eve; Isaiah J Fidler
Intravesical liposomal muramyl tripeptide phosphatidylethanolamine treatment of human bladder carcinoma growing in nude mice.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1995;15(6):585-92.
1995: R K Singh; M Gutman; Corazon D Bucana; R Sanchez; N Llansa; Isaiah J Fidler
Interferons alpha and beta down-regulate the expression of basic fibroblast growth factor in human carcinomas.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(10):4562-6.
1995: Keping Xie; Suyun Huang; Zhongyun Dong; SH Juang; M Gutman; Q W Xie; C Nathan; Isaiah J Fidler
Transfection with the inducible nitric oxide synthase gene suppresses tumorigenicity and abrogates metastasis by K-1735 murine melanoma cells.
The Journal of experimental medicine 1995;181(4):1333-43.
1995: Robert Radinsky; S Risin; Dominic Fan; Zhongyun Dong; Diane R Bielenberg; Corazon D Bucana; Isaiah J Fidler
Level and function of epidermal growth factor receptor predict the metastatic potential of human colon carcinoma cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 1995;1(1):19-31.
1995: Jerald J Killion; P Beltran; Catherine A O'Brian; S S Yoon; Dominic Fan; M R Wilson; Isaiah J Fidler
The antitumor activity of doxorubicin against drug-resistant murine carcinoma is enhanced by oral administration of a synthetic staurosporine analogue, CGP 41251.
Oncology research 1995;7(9):453-9.
1995: Robert Radinsky; P J Beltran; Rachel Tsan; R Zhang; R D Cone; Isaiah J Fidler
Transcriptional induction of the melanocyte-stimulating hormone receptor in brain metastases of murine K-1735 melanoma.
Cancer research 1995;55(1):141-8.
1994: S Tanguay; Corazon D Bucana; M R Wilson; Isaiah J Fidler; Andrew C von Eschenbach; Jerald J Killion
In vivo modulation of macrophage tumoricidal activity by oral administration of the liposome-encapsulated macrophage activator CGP 19835A.
Cancer research 1994;54(22):5882-8.
1994: Isaiah J Fidler; L M Ellis
The implications of angiogenesis for the biology and therapy of cancer metastasis.
Cell 1994;79(2):185-8.
1994: Suyun Huang; R K Singh; Keping Xie; M Gutman; K K Berry; Corazon D Bucana; Isaiah J Fidler; Menashe Bar-Eli
Expression of the JE/MCP-1 gene suppresses metastatic potential in murine colon carcinoma cells.
Cancer immunology, immunotherapy : CII 1994;39(4):231-8.
1994: R K Singh; Corazon D Bucana; M Gutman; D Fan; M R Wilson; Isaiah J Fidler
Organ site-dependent expression of basic fibroblast growth factor in human renal cell carcinoma cells.
The American journal of pathology 1994;145(2):365-74.
1994: K Gohji; Isaiah J Fidler; Rachel Tsan; Robert Radinsky; Andrew C von Eschenbach; T Tsuruo; M Nakajima
Human recombinant interferons-beta and -gamma decrease gelatinase production and invasion by human KG-2 renal-carcinoma cells.
International journal of cancer. Journal international du cancer 1994;58(3):380-4.
1994: Robert Radinsky; Isaiah J Fidler; Janet E Price; Noriko Esumi; Rachel Tsan; C M Petty; Corazon D Bucana; Menashe Bar-Eli
Terminal differentiation and apoptosis in experimental lung metastases of human osteogenic sarcoma cells by wild type p53.
Oncogene 1994;9(7):1877-83.
1994: R K Singh; M Gutman; Robert Radinsky; Corazon D Bucana; Isaiah J Fidler
Expression of interleukin 8 correlates with the metastatic potential of human melanoma cells in nude mice.
Cancer research 1994;54(12):3242-7.
1994: Zhongyun Dong; Robert Radinsky; Dominic Fan; Rachel Tsan; Corazon D Bucana; C Wilmanns; Isaiah J Fidler
Organ-specific modulation of steady-state mdr gene expression and drug resistance in murine colon cancer cells.
Journal of the National Cancer Institute 1994;86(12):913-20.
1994: Isaiah J Fidler; C Wilmanns; A Staroselsky; Robert Radinsky; Zhongyun Dong; Dominic Fan
Modulation of tumor cell response to chemotherapy by the organ environment.
Cancer metastasis reviews 1994;13(2):209-22.
1994: Jerald J Killion; Isaiah J Fidler
Systemic targeting of liposome-encapsulated immunomodulators to macrophages for treatment of cancer metastasis.
ImmunoMethods 1994;4(3):273-9.
1994: B Xie; Corazon D Bucana; Isaiah J Fidler
Density-dependent induction of 92-kd type IV collagenase activity in cultures of A431 human epidermoid carcinoma cells.
The American journal of pathology 1994;144(5):1058-67.
1994: B Xie; Zhongyun Dong; Isaiah J Fidler
Regulatory mechanisms for the expression of type IV collagenases/gelatinases in murine macrophages.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(7):3637-44.
1994: K Gohji; M Nakajima; A Fabra; Corazon D Bucana; Andrew C von Eschenbach; T Tsuruo; Isaiah J Fidler
Regulation of gelatinase production in metastatic renal cell carcinoma by organ-specific fibroblasts.
Japanese journal of cancer research : Gann 1994;85(2):152-60.
1994: Zhongyun Dong; A H Staroselsky; X Qi; Keping Xie; Isaiah J Fidler
Inverse correlation between expression of inducible nitric oxide synthase activity and production of metastasis in K-1735 murine melanoma cells.
Cancer research 1994;54(3):789-93.
1994: Dominic Fan; G Poste; C Seid; L E Earnest; T Bull; R K Clyne; Isaiah J Fidler
Reversal of multidrug resistance in murine fibrosarcoma cells by thioxanthene flupentixol.
Investigational new drugs 1994;12(3):185-95.
1994: Jerald J Killion; D R Brown; M R Wilson; M M Lloyd; Isaiah J Fidler
Prevention of chemotherapy- or X-irradiation-induced monocytopenia by oral administration of lipophilic muramyl tripeptide.
Oncology research 1994;6(8):357-64.
1994: M Gutman; R K Singh; Janet E Price; Dominic Fan; Isaiah J Fidler
Accelerated growth of human colon cancer cells in nude mice undergoing liver regeneration.
Invasion & metastasis 1994;14(1-6):362-71.
1994: M Gutman; R K Singh; S Yoon; Keping Xie; Corazon D Bucana; Isaiah J Fidler
Leukocyte-induced angiogenesis and subcutaneous growth of B16 melanoma.
Cancer biotherapy 1994;9(2):163-70.
1993: R K Singh; Isaiah J Fidler
Synergism between human recombinant monocyte chemotactic and activating factor and lipopolysaccharide for activation of antitumor properties in human blood monocytes.
Lymphokine and cytokine research 1993;12(5):285-91.
1993: R K Singh; K Berry; K Matsushima; K Yasumoto; Isaiah J Fidler
Synergism between human monocyte chemotactic and activating factor and bacterial products for activation of tumoricidal properties in murine macrophages.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(5):2786-93.
1993: Zhongyun Dong; X Qi; Keping Xie; Isaiah J Fidler
Protein tyrosine kinase inhibitors decrease induction of nitric oxide synthase activity in lipopolysaccharide-responsive and lipopolysaccharide-nonresponsive murine macrophages.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(5):2717-24.
1993: Jerald J Killion; Robert Radinsky; Zhongyun Dong; R Fishbeck; P Whitworth; Isaiah J Fidler
The immunogenic properties of drug-resistant murine tumor cells do not correlate with expression of the MDR phenotype.
Cancer immunology, immunotherapy : CII 1993;36(6):381-6.
1993: Zhongyun Dong; X Qi; Isaiah J Fidler
Tyrosine phosphorylation of mitogen-activated protein kinases is necessary for activation of murine macrophages by natural and synthetic bacterial products.
The Journal of experimental medicine 1993;177(4):1071-7.
1993: Robert Radinsky; Corazon D Bucana; Lee M Ellis; R Sanchez; Karen R Cleary; D J Brigati; Isaiah J Fidler
A rapid colorimetric in situ messenger RNA hybridization technique for analysis of epidermal growth factor receptor in paraffin-embedded surgical specimens of human colon carcinomas.
Cancer research 1993;53(5):937-43.
1993: MR Luca; B Hunt; Corazon D Bucana; J P Johnson; Isaiah J Fidler; Menashe Bar-Eli
Direct correlation between MUC18 expression and metastatic potential of human melanoma cells.
Melanoma research 1993;3(1):35-41.
1993: Zhongyun Dong; Catherine A O'Brian; Isaiah J Fidler
Activation of tumoricidal properties in macrophages by lipopolysaccharide requires protein-tyrosine kinase activity.
Journal of leukocyte biology 1993;53(1):53-60.
1993: S Risin; T Fujimaki; C A Mestriner; N M Brown; Vicki L Hopwood; Isaiah J Fidler; Sen Pathak
Clonal expansion of cells with trisomy of chromosomes 12 and X in an EBV-transformed lymphoblastoid cell line and establishment of a tumorigenic monoclonal cell line (48,XX,+X,+12).
Cytogenetics and cell genetics 1993;62(1):54-5.
1992: A Fabra; M Nakajima; Corazon D Bucana; Isaiah J Fidler
Modulation of the invasive phenotype of human colon carcinoma cells by organ specific fibroblasts of nude mice.
Differentiation; research in biological diversity 1992;52(1):101-10.
1992: Corazon D Bucana; A Fabra; R Sanchez; Isaiah J Fidler
Different patterns of macrophage infiltration into allogeneic-murine and xenogeneic-human neoplasms growing in nude mice.
The American journal of pathology 1992;141(5):1225-36.
1992: R D Zhang; Janet E Price; T Fujimaki; Corazon D Bucana; Isaiah J Fidler
Differential permeability of the blood-brain barrier in experimental brain metastases produced by human neoplasms implanted into nude mice.
The American journal of pathology 1992;141(5):1115-24.
1992: Stephen Ullrich; Isaiah J Fidler
Liposomes containing muramyl tripeptide phosphatidylethanolamine (MTP-PE) are excellent adjuvants for induction of an immune response to protein and tumor antigens.
Journal of leukocyte biology 1992;52(5):489-94.
1992: Robert Radinsky; H Z Weisberg; A N Staroselsky; Isaiah J Fidler
Expression level of the nm23 gene in clonal populations of metastatic murine and human neoplasms.
Cancer research 1992;52(20):5808-14.
1992: C Wilmanns; Dominic Fan; C A O'Brian; Corazon D Bucana; Isaiah J Fidler
Orthotopic and ectopic organ environments differentially influence the sensitivity of murine colon carcinoma cells to doxorubicin and 5-fluorouracil.
International journal of cancer. Journal international du cancer 1992;52(1):98-104.
1992: Robert Radinsky; Isaiah J Fidler
Regulation of tumor cell growth at organ-specific metastases.
In vivo (Athens, Greece) 1992;6(4):325-31.
1992: R A Stephenson; Colin P N Dinney; K Gohji; N G Ordóñez; Jerald J Killion; Isaiah J Fidler
Metastatic model for human prostate cancer using orthotopic implantation in nude mice.
Journal of the National Cancer Institute 1992;84(12):951-7.
1992: Dominic Fan; Isaiah J Fidler; Nancy E Ward; C Seid; L E Earnest; G M Housey; Catherine A O'Brian
Stable expression of a cDNA encoding rat brain protein kinase C-beta I confers a multidrug-resistant phenotype on rat fibroblasts.
Anticancer research 1992;12(3):661-7.
1992: A N Staroselsky; Robert Radinsky; Isaiah J Fidler; Sen Pathak; Y Chernajovsky; P Frost
The use of molecular genetic markers to demonstrate the effect of organ environment on clonal dominance in a human renal-cell carcinoma grown in nude mice.
International journal of cancer. Journal international du cancer 1992;51(1):130-8.
1992: Colin P N Dinney; T Utsugi; Isaiah J Fidler; Andrew C von Eschenbach; Jerald J Killion
Immunotherapy of murine renal adenocarcinoma by systemic administration of liposomes containing the synthetic macrophage activator CGP 31362 or CGP 19835A in combination with interleukin 2 or gamma-interferon.
Cancer research 1992;52(5):1155-61.
1992: Eugenie S Kleinerman; A Kevin Raymond; Corazon D Bucana; Norman Jaffe; Michael B Harris; I H Krakoff; R Benjamin; Isaiah J Fidler
Unique histological changes in lung metastases of osteosarcoma patients following therapy with liposomal muramyl tripeptide (CGP 19835A lipid).
Cancer immunology, immunotherapy : CII 1992;34(4):211-20.
1992: Jerald J Killion; Eugenie S Kleinerman; M R Wilson; M Tanaka; Isaiah J Fidler
Sequential therapy with chemotherapeutic drugs and liposome-encapsulated muramyl tripeptide: determination of potential interactions between these agents.
Oncology research 1992;4(10):413-8.
1992: T Utsugi; D Brown; A Nii; Isaiah J Fidler
Frozen-thawed human blood monocytes respond reproducibly to activation stimuli: implications for screening of BRMs.
Biotherapy (Dordrecht, Netherlands) 1992;5(4):301-8.
1991: A H Staroselsky; Sen Pathak; Y Chernajovsky; S L Tucker; Isaiah J Fidler
Predominance of the metastatic phenotype in somatic cell hybrids of the K-1735 murine melanoma.
Cancer research 1991;51(23 Pt 1):6292-8.
1991: T Utsugi; Colin P N Dinney; Jerald J Killion; D Brown; Isaiah J Fidler
In situ activation of mouse lung macrophages by coadministration of liposomes containing the lipopeptide CGP 31362 and interleukin 2 involves interaction with T lymphocytes and natural killer cells.
Lymphokine and cytokine research 1991;10(6):487-93.
1991: Sen Pathak; A N Staroselsky; Isaiah J Fidler
Specific chromosomal defects associated with metastatic potential in K-1735 melanoma clones. Involvement of chromosomes 4 and 14.
Cancer genetics and cytogenetics 1991;56(2):209-21.
1991: Isaiah J Fidler
Orthotopic implantation of human colon carcinomas into nude mice provides a valuable model for the biology and therapy of metastasis.
Cancer metastasis reviews 1991;10(3):229-43.
1991: Isaiah J Fidler
New developments in in vivo models of neoplasia.
Cancer metastasis reviews 1991;10(3):191-2.
1991: Noriko Esumi; Dominic Fan; Isaiah J Fidler
Inhibition of murine melanoma experimental metastasis by recombinant desulfatohirudin, a highly specific thrombin inhibitor.
Cancer research 1991;51(17):4549-56.
1991: A Nii; T Utsugi; Dominic Fan; Y Denkins; C Pak; D Brown; P van Hoogevest; Isaiah J Fidler
Optimization of the liposomes encapsulating a new lipopeptide CGP 31362 for efficient activation of tumoricidal properties in monocytes and macrophages.
Journal of immunotherapy : official journal of the Society for Biological Therapy 1991;10(4):236-46.
1991: Colin P N Dinney; Corazon D Bucana; T Utsugi; Isaiah J Fidler; Andrew C von Eschenbach; Jerald J Killion
Therapy of spontaneous lung metastasis of murine renal adenocarcinoma by systemic administration of liposomes containing the macrophage activator CGP 31362.
Cancer research 1991;51(14):3741-7.
1991: T Utsugi; Alan J Schroit; J Connor; Corazon D Bucana; Isaiah J Fidler
Elevated expression of phosphatidylserine in the outer membrane leaflet of human tumor cells and recognition by activated human blood monocytes.
Cancer research 1991;51(11):3062-6.
1991: C C Pak; Isaiah J Fidler
Molecular mechanisms for activated macrophage recognition of tumor cells.
Seminars in cancer biology 1991;2(3):189-95.
1991: L M Li; R G Kilbourn; J Adams; Isaiah J Fidler
Role of nitric oxide in lysis of tumor cells by cytokine-activated endothelial cells.
Cancer research 1991;51(10):2531-5.
1991: R D Zhang; Janet E Price; Gabriele Schackert; Kyogo Itoh; Isaiah J Fidler
Malignant potential of cells isolated from lymph node or brain metastases of melanoma patients and implications for prognosis.
Cancer research 1991;51(8):2029-35.
1991: T Utsugi; Isaiah J Fidler
Prostaglandin E2 does not inhibit tumoricidal activity of mouse macrophages against adherent tumor cells.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(6):2066-71.
1991: Catherine A O'Brian; Dominic Fan; Nancy E Ward; Zhongyun Dong; L Iwamoto; K P Gupta; L E Earnest; Isaiah J Fidler
Transient enhancement of multidrug resistance by the bile acid deoxycholate in murine fibrosarcoma cells in vitro.
Biochemical pharmacology 1991;41(5):797-806.
1991: A Nii; Dominic Fan; Isaiah J Fidler
Cytotoxic potential of liposomes containing tumor necrosis factor-alpha against sensitive and resistant target cells.
Journal of immunotherapy : official journal of the Society for Biological Therapy 1991;10(1):13-9.
1991: Isaiah J Fidler; L M Li; Honnavara N Ananthaswamy; Noriko Esumi; Robert Radinsky; Janet E Price
Correlation of growth capacity of cells in hard agarose with successful transfection by the activated c-Ha-ras oncogene and in vivo proliferative capacity at metastatic sites.
Anticancer research 1991;11(1):17-24.
1991: C C Pak; Isaiah J Fidler
Liposomal delivery of biological response modifiers to macrophages.
Biotherapy (Dordrecht, Netherlands) 1991;3(1):55-64.
1991: L M Li; Garth L Nicolson; Isaiah J Fidler
Direct in vitro lysis of metastatic tumor cells by cytokine-activated murine vascular endothelial cells.
Cancer research 1991;51(1):245-54.
1991: T Utsugi; Colin P N Dinney; Jerald J Killion; Isaiah J Fidler
In situ activation of mouse macrophages and therapy of spontaneous renal cell cancer metastasis by liposomes containing the lipopeptide CGP 31362.
Cancer immunology, immunotherapy : CII 1991;33(6):375-81.
1991: T Utsugi; A Nii; Dominic Fan; C C Pak; Y Denkins; P van Hoogevest; Isaiah J Fidler
Comparative efficacy of liposomes containing synthetic bacterial cell wall analogues for tumoricidal activation of monocytes and macrophages.
Cancer immunology, immunotherapy : CII 1991;33(5):285-92.
1991: C A Seid; Isaiah J Fidler; R K Clyne; L E Earnest; Dominic Fan
Overcoming murine tumor cell resistance to vinblastine by presentation of the drug in multilamellar liposomes consisting of phosphatidylcholine and phosphatidylserine.
Selective cancer therapeutics 1991;7(3):103-12.
1991: R D Zhang; Isaiah J Fidler; Janet E Price
Relative malignant potential of human breast carcinoma cell lines established from pleural effusions and a brain metastasis.
Invasion & metastasis 1991;11(4):204-15.
1991: Isaiah J Fidler
7th Jan Waldenström Lecture. The biology of human cancer metastasis.
Acta oncologica (Stockholm, Sweden) 1991;30(6):668-75.
1990: M Nakajima; K Morikawa; A Fabra; Corazon D Bucana; Isaiah J Fidler
Influence of organ environment on extracellular matrix degradative activity and metastasis of human colon carcinoma cells.
Journal of the National Cancer Institute 1990;82(24):1890-8.
1990: A N Staroselsky; Dominic Fan; Catherine A O'Brian; Corazon D Bucana; K P Gupta; Isaiah J Fidler
Site-dependent differences in response of the UV-2237 murine fibrosarcoma to systemic therapy with adriamycin.
Cancer research 1990;50(24):7775-80.
1990: Isaiah J Fidler
Critical factors in the biology of human cancer metastasis: twenty-eighth G.H.A. Clowes memorial award lecture.
Cancer research 1990;50(19):6130-8.
1990: Isaiah J Fidler; S Naito; S Pathak
Orthotopic implantation is essential for the selection, growth and metastasis of human renal cell cancer in nude mice [corrected].
Cancer metastasis reviews 1990;9(2):149-65.
1990: Dong M Shin; Isaiah J Fidler; C D Bucana; Dominic Fan; Waun Ki Hong; Jerald J Killion
Superior antiproliferative effects mediated by interferon-alpha entrapped in liposomes against a newly established human lung cancer cell line.
Journal of biological response modifiers 1990;9(4):355-60.
1990: Dominic Fan; Corazon D Bucana; Catherine A O'Brian; Leonard A Zwelling; C Seid; Isaiah J Fidler
Enhancement of murine tumor cell sensitivity to adriamycin by presentation of the drug in phosphatidylcholine-phosphatidylserine liposomes.
Cancer research 1990;50(12):3619-26.
1990: D N Frangos; Jerald J Killion; Dominic Fan; R Fishbeck; Andrew C von Eschenbach; Isaiah J Fidler
The development of liposomes containing interferon alpha for the intravesical therapy of human superficial bladder cancer.
The Journal of urology 1990;143(6):1252-6.
1990: C Q Wang; Margaret L Kripke; Isaiah J Fidler
Ultraviolet-B-irradiated mouse epidermis releases mediators that stimulate melanoma cells.
Photodermatology, photoimmunology & photomedicine 1990;7(3):128-35.
1990: A Staroselsky; Sen Pathak; Isaiah J Fidler
Changes in clonal composition during in vivo growth of mixed subpopulations derived from the murine K-1735 melanoma.
Anticancer research 1990;10(2A):291-6.
1990: P W Whitworth; C C Pak; J Esgro; E S Kleinerman; Isaiah J Fidler
Macrophages and cancer.
Cancer metastasis reviews 1990;8(4):319-51.
1990: Hans K Schackert; Dominic Fan; Isaiah J Fidler
Transient inhibition of liver regeneration in mice by transforming growth factor-beta 1 encapsulated in liposomes.
Cancer communications 1990;2(5):165-71.
1990: A Nii; Isaiah J Fidler
The incubation of human blood monocytes with tumor necrosis factor-alpha leads to lysis of tumor necrosis factor-sensitive but not resistant tumor cells.
Lymphokine research 1990;9(2):113-24.
1990: L M Li; Dong M Shin; Isaiah J Fidler
Intrabronchial implantation of the Lewis lung tumor cell does not favor tumorigenicity and metastasis.
Invasion & metastasis 1990;10(3):129-41.
1990: Gabriele Schackert; Janet E Price; R D Zhang; Corazon D Bucana; Kyogo Itoh; Isaiah J Fidler
Regional growth of different human melanomas as metastases in the brain of nude mice.
The American journal of pathology 1990;136(1):95-102.
1990: Isaiah J Fidler; A Nii; T Utsugi; D Brown; O Bakouche; Eugenie S Kleinerman
Differential release of TNF-alpha, IL 1, and PGE2 by human blood monocytes subsequent to interaction with different bacterial derived agents.
Lymphokine research 1990;9(4):449-63.
1989: J M Jessup; R Giavazzi; D Campbell; Karen R Cleary; K Morikawa; R Hostetter; E Neely Atkinson; Isaiah J Fidler
Metastatic potential of human colorectal carcinomas implanted into nude mice: prediction of clinical outcome in patients operated upon for cure.
Cancer research 1989;49(24 Pt 1):6906-10.
1989: L Li; Janet E Price; Dominic Fan; R D Zhang; Corazon D Bucana; Isaiah J Fidler
Correlation of growth capacity of human tumor cells in hard agarose with their in vivo proliferative capacity at specific metastatic sites.
Journal of the National Cancer Institute 1989;81(18):1406-12.
1989: Jerald J Killion; Dominic Fan; Corazon D Bucana; D N Frangos; Janet E Price; Isaiah J Fidler
Augmentation of antiproliferative activity of interferon alfa against human bladder tumor cell lines by encapsulation of interferon alfa within liposomes.
Journal of the National Cancer Institute 1989;81(18):1387-92.
1989: Eugenie S Kleinerman; James L Murray; J S Snyder; Joan E. Cunningham; Isaiah J Fidler
Activation of tumoricidal properties in monocytes from cancer patients following intravenous administration of liposomes containing muramyl tripeptide phosphatidylethanolamine.
Cancer research 1989;49(16):4665-70.
1989: Janet E Price; SL Aukerman; Honnavara N Ananthaswamy; B W McIntyre; Gabriele Schackert; Hans K Schackert; Isaiah J Fidler
Metastatic potential of cloned murine melanoma cells transfected with activated c-Ha-ras.
Cancer research 1989;49(15):4274-81.
1989: Hans K Schackert; Isaiah J Fidler
Development of an animal model to study the biology of recurrent colorectal cancer originating from mesenteric lymph system metastases.
International journal of cancer. Journal international du cancer 1989;44(1):177-81.
1989: C C Pak; Isaiah J Fidler
Activated macrophages distinguish undifferentiated-tumorigenic from differentiated-nontumorigenic murine erythroleukemia cells.
Differentiation; research in biological diversity 1989;41(1):49-55.
1989: D R McCready; Charles M Balch; Isaiah J Fidler; James L Murray
Lack of comparability between binding of monoclonal antibodies to melanoma cells in vitro and localization in vivo.
Journal of the National Cancer Institute 1989;81(9):682-7.
1989: J Connor; Corazon D Bucana; Isaiah J Fidler; Alan J Schroit
Differentiation-dependent expression of phosphatidylserine in mammalian plasma membranes: quantitative assessment of outer-leaflet lipid by prothrombinase complex formation.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(9):3184-8.
1989: Jerald J Killion; Isaiah J Fidler
The biology of tumor metastasis.
Seminars in oncology 1989;16(2):106-15.
1989: K Morikawa; Isaiah J Fidler
Heterogeneous response of human colon cancer cells to the cytostatic and cytotoxic effects of recombinant human cytokines: interferon-alpha, interferon-gamma, tumor necrosis factor, and interleukin-1.
Journal of biological response modifiers 1989;8(2):206-18.
1989: Catherine A O'Brian; Dominic Fan; Nancy E Ward; C Seid; Isaiah J Fidler
Level of protein kinase C activity correlates directly with resistance to adriamycin in murine fibrosarcoma cells.
FEBS letters 1989;246(1-2):78-82.
1989: K Morikawa; Dominic Fan; Y M Denkins; Bernard Levin; Jordan U Gutterman; S M Walker; Isaiah J Fidler
Mechanisms of combined effects of gamma-interferon and 5-fluorouracil on human colon cancers implanted into nude mice.
Cancer research 1989;49(4):799-805.
1989: Isaiah J Fidler; A Nii; J Y Tsao; S Davis; Eugenie S Kleinerman
Activated human blood monocytes trigger the antitumor activity of blood polymorphonuclear cells.
Lymphokine research 1989;8(4):427-37.
1989: Isaiah J Fidler; Y Ichinose
Mechanisms of macrophage-mediated tumor cell lysis: role for the monokines tumor necrosis factor and interleukin 1.
Progress in clinical and biological research 1989;288():169-81.
1989: Gabriele Schackert; Dominic Fan; R Nayar; Isaiah J Fidler
Arrest and retention of multilamellar liposomes in the brain of normal mice or mice bearing experimental brain metastases.
Selective cancer therapeutics 1989;5(2):73-9.
1989: Dominic Fan; J Price; Hans K Schackert; C Seid; C Wilmanns; S Chakrabarty; Isaiah J Fidler
Antiproliferative activity of liposome-encapsulated transforming growth factor-beta against MDA-MB-435 human breast carcinoma cells.
Cancer communications 1989;1(6):337-43.
1989: David A Hume; R E Donahue; Isaiah J Fidler
The therapeutic effect of human recombinant macrophage colony stimulating factor (CSF-1) in experimental murine metastatic melanoma.
Lymphokine research 1989;8(1):69-77.
1989: J W Johnson; R Nayar; Jerald J Killion; A C von Eschenbach; Isaiah J Fidler
Binding of liposomes to human bladder tumor epithelial cell lines: implications for an intravesical drug delivery system for the treatment of bladder cancer.
Selective cancer therapeutics 1989;5(4):147-55.
1989: Dominic Fan; S Chakrabarty; C Seid; C W Bell; Hans K Schackert; K Morikawa; Isaiah J Fidler
Clonal stimulation or inhibition of human colon carcinomas and human renal carcinomas mediated by transforming growth factor-beta 1.
Cancer communications 1989;1(2):117-25.
1989: Isaiah J Fidler; Dominic Fan; Y Ichinose
Potent in situ activation of murine lung macrophages and therapy of melanoma metastases by systemic administration of liposomes containing muramyltripeptide phosphatidylethanolamine and interferon gamma.
Invasion & metastasis 1989;9(2):75-88.
1988: K Morikawa; S M Walker; M Nakajima; Sen Pathak; J M Jessup; Isaiah J Fidler
Influence of organ environment on the growth, selection, and metastasis of human colon carcinoma cells in nude mice.
Cancer research 1988;48(23):6863-71.
1988: David A Hume; P Pavli; R E Donahue; Isaiah J Fidler
The effect of human recombinant macrophage colony-stimulating factor (CSF-1) on the murine mononuclear phagocyte system in vivo.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(10):3405-9.
1988: Gabriele Schackert; R D Simmons; T M Buzbee; D A Hume; Isaiah J Fidler
Macrophage infiltration into experimental brain metastases: occurrence through an intact blood-brain barrier.
Journal of the National Cancer Institute 1988;80(13):1027-34.
1988: J E Price; D N Sauder; Isaiah J Fidler
Tumorigenicity and metastatic behavior in nude mice of two human squamous cell carcinoma lines that differ in production of the cytokine ETAF/IL-1.
The Journal of investigative dermatology 1988;91(3):258-62.
1988: Isaiah J Fidler
The biology of melanoma metastasis.
The Journal of dermatologic surgery and oncology 1988;14(8):875-81.
1988: C A Romerdahl; C Donawho; Isaiah J Fidler; Margaret L Kripke
Effect of ultraviolet-B radiation on the in vivo growth of murine melanoma cells.
Cancer research 1988;48(14):4007-10.
1988: Y Ichinose; O Bakouche; J Y Tsao; Isaiah J Fidler
Tumor necrosis factor and IL-1 associated with plasma membranes of activated human monocytes lyse monokine-sensitive but not monokine-resistant tumor cells whereas viable activated monocytes lyse both.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(2):512-8.
1988: Gabriele Schackert; Isaiah J Fidler
Site-specific metastasis of mouse melanomas and a fibrosarcoma in the brain or meninges of syngeneic animals.
Cancer research 1988;48(12):3478-84.
1988: Gabriele Schackert; Isaiah J Fidler
Development of in vivo models for studies of brain metastasis.
International journal of cancer. Journal international du cancer 1988;41(4):589-94.
1988: Janet E Price; D Tarin; Isaiah J Fidler
Influence of organ microenvironment on pigmentation of a metastatic murine melanoma.
Cancer research 1988;48(8):2258-64.
1988: K Morikawa; S M Walker; J M Jessup; Isaiah J Fidler
In vivo selection of highly metastatic cells from surgical specimens of different primary human colon carcinomas implanted into nude mice.
Cancer research 1988;48(7):1943-8.
1988: O Bakouche; Y Ichinose; Rüdiger Heicappell; Isaiah J Fidler; L B Lachman
Plasma membrane-associated tumor necrosis factor. A non-integral membrane protein possibly bound to its own receptor.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(4):1142-7.
1988: K Morikawa; R Nayar; Isaiah J Fidler
In vitro activation of tumoricidal properties in mouse macrophages using the chemotactic peptide N-formyl-methionyl-leucyl-phenylalanine (FMLP) incorporated in liposomes.
Cancer immunology, immunotherapy : CII 1988;27(1):1-6.
1988: Y Ichinose; J Y Tsao; Isaiah J Fidler
Destruction of tumor cells by monokines released from activated human blood monocytes: evidence for parallel and additive effects of IL-1 and TNF.
Cancer immunology, immunotherapy : CII 1988;27(1):7-12.
1988: Janet E Price; S Naito; Isaiah J Fidler
Growth in an organ microenvironment as a selective process in metastasis.
Clinical & experimental metastasis 1988;6(1):91-102.
1987: R Nayar; K Morikawa; Isaiah J Fidler
Characterization of liposomes containing the chemotactic peptide N-formyl-methionyl-leucyl-phenylalanine (FMLP) and their interaction with mouse macrophages.
Cancer drug delivery 1987;4(4):233-44.
1987: SL Aukerman; Isaiah J Fidler
Antigenicity of UV radiation-induced murine tumors correlates positively with the level of adenosine deaminase activity.
Cancer immunology, immunotherapy : CII 1987;25(3):175-9.
1986: Janet E Price; SL Aukerman; Isaiah J Fidler
Evidence that the process of murine melanoma metastasis is sequential and selective and contains stochastic elements.
Cancer research 1986;46(10):5172-8.
1986: SL Aukerman; Janet E Price; Isaiah J Fidler
Different deficiencies in the prevention of tumorigenic-low-metastatic murine K-1735b melanoma cells from producing metastases.
Journal of the National Cancer Institute 1986;77(4):915-24.

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