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Isaiah Fidler

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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TOP 3
Langley Robert R; Fan Dominic; Guo Lixia; Zhang Chenyu; Lin Qingtang; Brantley Emily C; McCarty Joseph H; Fidler Isaiah J
Generation of an immortalized astrocyte cell line from H-2Kb-tsA58 mice to study the role of astrocytes in brain metastasis.
Kim Sun-Jin; Kim Jang-Seong; Papadopoulos John; Wook Kim Seung; Maya Marva; Zhang Fahao; He Junquin; Fan Dominic; Langley Robert; Fidler Isaiah J
Circulating monocytes expressing CD31: implications for acute and chronic angiogenesis.
Zhang Chenyu; Zhang Fahao; Tsan Rachel; Fidler Isaiah J
Transforming growth factor-beta2 is a molecular determinant for site-specific melanoma metastasis in the brain.

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All Publications

2009: Langley Robert R; Fan Dominic; Guo Lixia; Zhang Chenyu; Lin Qingtang; Brantley Emily C; McCarty Joseph H; Fidler Isaiah J
Generation of an immortalized astrocyte cell line from H-2Kb-tsA58 mice to study the role of astrocytes in brain metastasis.
International journal of oncology 2009;35(4):665-72.
2009: Kim Sun-Jin; Kim Jang-Seong; Papadopoulos John; Wook Kim Seung; Maya Marva; Zhang Fahao; He Junquin; Fan Dominic; Langley Robert; Fidler Isaiah J
Circulating monocytes expressing CD31: implications for acute and chronic angiogenesis.
The American journal of pathology 2009;174(5):1972-80.
2009: Zhang Chenyu; Zhang Fahao; Tsan Rachel; Fidler Isaiah J
Transforming growth factor-beta2 is a molecular determinant for site-specific melanoma metastasis in the brain.
Cancer research 2009;69(3):828-35.
2008: Mathew P; Thall P F; Wen S; Bucana C; Jones D; Horne E; Oh W K; Morris M J; Lee Y-C; Logothetis C J; Lin S-H; Fidler I J
Dynamic change in phosphorylated platelet-derived growth factor receptor in peripheral blood leukocytes following docetaxel therapy predicts progression-free and overall survival in prostate cancer.
British journal of cancer 2008;99(9):1426-32.
2008: Giordano Ricardo J; Lahdenranta Johanna; Zhen Lijie; Chukwueke Ugonma; Petrache Irina; Langley Robert R; Fidler Isaiah J; Pasqualini Renata; Tuder Rubin M; Arap Wadih
Targeted induction of lung endothelial cell apoptosis causes emphysema-like changes in the mouse.
The Journal of biological chemistry 2008;283(43):29447-60.
2008: Fidler Isaiah J; Poste George
The "seed and soil" hypothesis revisited.
The lancet oncology 2008;9(8):808.
2008: Sasaki Takamitsu; Nakamura Toru; Rebhun Robert B; Cheng Hua; Hale Katherine Stemke; Tsan Rachel Z; Fidler Isaiah J; Langley Robert R
Modification of the primary tumor microenvironment by transforming growth factor alpha-epidermal growth factor receptor signaling promotes metastasis in an orthotopic colon cancer model.
The American journal of pathology 2008;173(1):205-16.
2008: Kuwai Toshio; Nakamura Toru; Sasaki Takamitsu; Kim Sun-Jin; Fan Dominic; Villares Gabriel J; Zigler Maya; Wang Hua; Bar-Eli Menashe; Kerbel Robert S; Fidler Isaiah J
Phosphorylated epidermal growth factor receptor on tumor-associated endothelial cells is a primary target for therapy with tyrosine kinase inhibitors.
Neoplasia (New York, N.Y.) 2008;10(5):489-500.
2008: Weihua Zhang; Tsan Rachel; Huang Wei-Chien; Wu Qiuyu; Chiu Chao-Hua; Fidler Isaiah J; Hung Mien-Chie
Survival of cancer cells is maintained by EGFR independent of its kinase activity.
Cancer cell 2008;13(5):385-93.
2008: Kuwai Toshio; Nakamura Toru; Kim Sun-Jin; Sasaki Takamitsu; Kitadai Yasuhiko; Langley Robert R; Fan Dominic; Hamilton Stanley R; Fidler Isaiah J
Intratumoral heterogeneity for expression of tyrosine kinase growth factor receptors in human colon cancer surgical specimens and orthotopic tumors.
The American journal of pathology 2008;172(2):358-66.
2008: Kuwai Toshio; Nakamura Toru; Sasaki Takamitsu; Kitadai Yasuhiko; Kim Jang-Seong; Langley Robert R; Fan Dominic; Wang Xuemei; Do Kim-Anh; Kim Sun-Jin; Fidler Isaiah J
Targeting the EGFR, VEGFR, and PDGFR on colon cancer cells and stromal cells is required for therapy.
Clinical & experimental metastasis 2008;25(4):477-89.
2008: Rebhun Robert B; Lazar Alexander J F; Fidler Isaiah J; Gershenwald Jeffrey E
Impact of sentinel lymphadenectomy on survival in a murine model of melanoma.
Clinical & experimental metastasis 2008;25(3):191-9.
2007: Sasaki Takamitsu; Kitadai Yasuhiko; Nakamura Toru; Kim Jang-Seong; Tsan Rachel Z; Kuwai Toshio; Langley Robert R; Fan Dominic; Kim Sun-Jin; Fidler Isaiah J
Inhibition of epidermal growth factor receptor and vascular endothelial growth factor receptor phosphorylation on tumor-associated endothelial cells leads to treatment of orthotopic human colon cancer in nude mice.
Neoplasia (New York, N.Y.) 2007;9(12):1066-77.
2007: Nakamura Toru; Kuwai Toshio; Kim Jang-Seong; Fan Dominic; Kim Sun-Jin; Fidler Isaiah J
Stromal metalloproteinase-9 is essential to angiogenesis and progressive growth of orthotopic human pancreatic cancer in parabiont nude mice.
Neoplasia (New York, N.Y.) 2007;9(11):979-86.
2007: Wu Wenjuan; O'Reilly Michael S; Langley Robert R; Tsan Rachel Z; Baker Cheryl H; Bekele Neby; Tang Xi Ming; Onn Amir; Fidler Isaiah J; Herbst Roy S
Expression of epidermal growth factor (EGF)/transforming growth factor-alpha by human lung cancer cells determines their response to EGF receptor tyrosine kinase inhibition in the lungs of mice.
Molecular cancer therapeutics 2007;6(10):2652-63.
2007: Mathew Paul; Thall Peter F; Bucana Corazon D; Oh William K; Morris Michael J; Jones Donnah M; Johnson Marcella M; Wen Sijin; Pagliaro Lance C; Tannir Nizar M; Tu Shi-Ming; Meluch Anthony A; Smith Lon; Cohen Lorenzo; Kim Sun-Jin; Troncoso Patricia; Fidler Isaiah J; Logothetis Christopher J
Platelet-derived growth factor receptor inhibition and chemotherapy for castration-resistant prostate cancer with bone metastases.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(19):5816-24.
2007: Nakamura Toru; Kuwai Toshio; Kitadai Yasuhiko; Sasaki Takamitsu; Fan Dominic; Coombes Kevin R; Kim Sun-Jin; Fidler Isaiah J
Zonal heterogeneity for gene expression in human pancreatic carcinoma.
Cancer research 2007;67(16):7597-604.
2007: Fidler Isaiah J; Kim Sun-Jin; Langley Robert R
The role of the organ microenvironment in the biology and therapy of cancer metastasis.
Journal of cellular biochemistry 2007;101(4):927-36.
2007: Langley Robert R; Fidler Isaiah J
Tumor cell-organ microenvironment interactions in the pathogenesis of cancer metastasis.
Endocrine reviews 2007;28(3):297-321.
2007: Talmadge James E; Singh Rakesh K; Fidler Isaiah J; Raz Avraham
Murine models to evaluate novel and conventional therapeutic strategies for cancer.
The American journal of pathology 2007;170(3):793-804.
2007: Wu Wenjuan; Onn Amir; Isobe Takeshi; Itasaka Satoshi; Langley Robert R; Shitani Tomoaki; Shibuya Keiko; Komaki Ritsuko; Ryan Anderson J; Fidler Isaiah J; Herbst Roy S; O'Reilly Michael S
Targeted therapy of orthotopic human lung cancer by combined vascular endothelial growth factor and epidermal growth factor receptor signaling blockade.
Molecular cancer therapeutics 2007;6(2):471-83.
2007: Nakamura Toru; Fidler Isaiah J; Coombes Kevin R
Gene expression profile of metastatic human pancreatic cancer cells depends on the organ microenvironment.
Cancer research 2007;67(1):139-48.
2006: Kitadai Yasuhiko; Sasaki Takamitsu; Kuwai Toshio; Nakamura Toru; Bucana Corazon D; Fidler Isaiah J
Targeting the expression of platelet-derived growth factor receptor by reactive stroma inhibits growth and metastasis of human colon carcinoma.
The American journal of pathology 2006;169(6):2054-65.
2006: Busby J Erik; Kim Sun-Jin; Yazici Sertac; Nakamura Toru; Kim Jang-Seong; He Junqin; Maya Marva; Wang Xuemei; Do Kim-Anh; Fan Dominic; Fidler Isaiah J
Therapy of multidrug resistant human prostate tumors in the prostate of nude mice by simultaneous targeting of the epidermal growth factor receptor and vascular endothelial growth factor receptor on tumor-associated endothelial cells.
The Prostate 2006;66(16):1788-98.
2006: Kitadai Yasuhiko; Sasaki Takamitsu; Kuwai Toshio; Nakamura Toru; Bucana Corazon D; Hamilton Stanley R; Fidler Isaiah J
Expression of activated platelet-derived growth factor receptor in stromal cells of human colon carcinomas is associated with metastatic potential.
International journal of cancer. Journal international du cancer 2006;119(11):2567-74.
2006: Fidler Isaiah J
Models for spontaneous metastasis.
Cancer research 2006;66(19):9787.
2006: Rebhun Robert B; Langley Robert R; Yokoi Kenji; Fan Dominic; Gershenwald Jeffrey E; Fidler Isaiah J
Targeting receptor tyrosine kinase on lymphatic endothelial cells for the therapy of colon cancer lymph node metastasis.
Neoplasia (New York, N.Y.) 2006;8(9):747-57.
2006: Fidler Isaiah J
Antivascular therapy of cancer metastasis.
Journal of surgical oncology 2006;94(3):178-80.
2006: Zhang Weihua; Tsan Rachel; Nam Do-Hyun; Lu Weixin; Fidler Isaiah J
Loss of adhesion in the circulation converts amelanotic metastatic melanoma cells to melanotic by inhibition of AKT.
Neoplasia (New York, N.Y.) 2006;8(7):543-50.
2006: Baker Cheryl H; Trevino Jose G; Summy Justin M; Zhang Fahao; Caron Alexis; Nesbit Mark; Gallick Gary E; Fidler Isaiah J
Inhibition of PDGFR phosphorylation and Src and Akt activity by GN963 leads to therapy of human pancreatic cancer growing orthotopically in nude mice.
International journal of oncology 2006;29(1):125-38.
2006: Baker Cheryl H; Pino Maria S; Fidler Isaiah J
Phosphorylated epidermal growth factor receptor on tumor-associated endothelial cells in human renal cell carcinoma is a primary target for therapy by tyrosine kinase inhibitors.
Neoplasia (New York, N.Y.) 2006;8(6):470-6.
2006: Kim Sun-Jin; Uehara Hisanori; Yazici Sertac; Busby Joseph Erik; Nakamura Toru; He Junqin; Maya Marva; Logothetis Christopher; Mathew Paul; Wang Xuemei; Do Kim-Anh; Fan Dominic; Fidler Isaiah J
Targeting platelet-derived growth factor receptor on endothelial cells of multidrug-resistant prostate cancer.
Journal of the National Cancer Institute 2006;98(11):783-93.
2005: Weihua Zhang; Tsan Rachel; Schroit Alan J; Fidler Isaiah J
Apoptotic cells initiate endothelial cell sprouting via electrostatic signaling.
Cancer research 2005;65(24):11529-35.
2005: Cheng Hua; Langley Robert R; Wu Qiuyu; Wu Wenjuan; Feng Jie; Tsan Rachel; Fan Dominic; Fidler Isaiah J
Construction of a novel constitutively active chimeric EGFR to identify new targets for therapy.
Neoplasia (New York, N.Y.) 2005;7(12):1065-72.
2005: Fidler Isaiah J
Blockade of the TGF-beta superfamily by Smad7: breaking a link in the metastatic chain.
Journal of the National Cancer Institute 2005;97(23):1714-5.
2005: Nilsson Monique B; Langley Robert R; Fidler Isaiah J
Interleukin-6, secreted by human ovarian carcinoma cells, is a potent proangiogenic cytokine.
Cancer research 2005;65(23):10794-800.
2005: Yokoi Kenji; Sasaki Takamitsu; Bucana Corazon D; Fan Dominic; Baker Cheryl H; Kitadai Yasuhiko; Kuwai Toshio; Abbruzzese James L; Fidler Isaiah J
Simultaneous inhibition of EGFR, VEGFR, and platelet-derived growth factor receptor signaling combined with gemcitabine produces therapy of human pancreatic carcinoma and prolongs survival in an orthotopic nude mouse model.
Cancer research 2005;65(22):10371-80.
2005: Yokoi Kenji; Shih Li-Chen Nancy; Kobayashi Ryuji; Koomen John; Hawke David; Li Donghui; Hamilton Stanley R; Abbruzzese James L; Coombes Kevin R; Fidler Isaiah J
Serum amyloid A as a tumor marker in sera of nude mice with orthotopic human pancreatic cancer and in plasma of patients with pancreatic cancer.
International journal of oncology 2005;27(5):1361-9.
2005: Yazici S; Kim S J; Busby J E; He J; Thaker P; Yokoi K; Fan D; Fidler I J
Dual inhibition of the epidermal growth factor and vascular endothelial growth factor phosphorylation for antivascular therapy of human prostate cancer in the prostate of nude mice.
The Prostate 2005;65(3):203-15.
2005: Hoekstra Ronald; Dumez Herlinde; Eskens Ferry A L M; van der Gaast Ate; Planting Andre S T; de Heus Gerda; Sizer Kurt C; Ravera Christina; Vaidyanathan Sujata; Bucana Corazon; Fidler Isaiah J; van Oosterom Allan T; Verweij Jaap
Phase I and pharmacologic study of PKI166, an epidermal growth factor receptor tyrosine kinase inhibitor, in patients with advanced solid malignancies.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(19 Pt 1):6908-15.
2005: Fidler Isaiah J
Cancer biology is the foundation for therapy.
Cancer biology & therapy 2005;4(9):1036-9.
2005: Yokoi Kenji; Kim Sun-Jin; Thaker Premal; Yazici Sertac; Nam Do-Hyun; He Junqin; Sasaki Takamitsu; Chiao Paul J; Sclabas Guido M; Abbruzzese James L; Hamilton Stanley R; Fidler Isaiah J
Induction of apoptosis in tumor-associated endothelial cells and therapy of orthotopic human pancreatic carcinoma in nude mice.
Neoplasia (New York, N.Y.) 2005;7(7):696-704.
2005: Thaker Premal H; Yazici Sertac; Nilsson Monique B; Yokoi Kenji; Tsan Rachel Z; He Junqin; Kim Sun-Jin; Fidler Isaiah J; Sood Anil K
Antivascular therapy for orthotopic human ovarian carcinoma through blockade of the vascular endothelial growth factor and epidermal growth factor receptors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(13):4923-33.
2005: Younes Maher Nabil; Yigitbasi Orhan Gazi; Park Young Wook; Kim Sun-Jin; Jasser Samar A; Hawthorne Valerie Stone; Yazici Yasemin Dakak; Mandal Mahitosh; Bekele Benjamin Nebiyou; Bucana Corazon D; Fidler Isaiah J; Myers Jeffrey N
Antivascular therapy of human follicular thyroid cancer experimental bone metastasis by blockade of epidermal growth factor receptor and vascular growth factor receptor phosphorylation.
Cancer research 2005;65(11):4716-27.
2005: Uehara Hisanori; Troncoso Patricia; Johnston Dennis; Bucana Corazon D; Dinney Colin; Dong Zhongyun; Fidler Isaiah J; Pettaway Curtis A
Expression of interleukin-8 gene in radical prostatectomy specimens is associated with advanced pathologic stage.
The Prostate 2005;64(1):40-9.
2005: Yokoi Kenji; Thaker Premal H; Yazici Sertac; Rebhun Robert R; Nam Do-Hyun; He Junqin; Kim Sun-Jin; Abbruzzese James L; Hamilton Stanley R; Fidler Isaiah J
Dual inhibition of epidermal growth factor receptor and vascular endothelial growth factor receptor phosphorylation by AEE788 reduces growth and metastasis of human colon carcinoma in an orthotopic nude mouse model.
Cancer research 2005;65(9):3716-25.
2005: Kim Sun-Jin; Uehara Hisanori; Yazici Sertac; He Junqin; Langley Robert R; Mathew Paul; Fan Dominic; Fidler Isaiah J
Modulation of bone microenvironment with zoledronate enhances the therapeutic effects of STI571 and paclitaxel against experimental bone metastasis of human prostate cancer.
Cancer research 2005;65(9):3707-15.
2005: Koomen John M; Shih Lichen Nancy; Coombes Kevin R; Li Donghui; Xiao Lian-chun; Fidler Isaiah J; Abbruzzese James L; Kobayashi Ryuji
Plasma protein profiling for diagnosis of pancreatic cancer reveals the presence of host response proteins.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(3):1110-8.
2005: Sclabas Guido M; Fujioka Shuichi; Schmidt Christian; Li Zhongkui; Frederick Wayne A I; Yang Wentao; Yokoi Kenji; Evans Douglas B; Abbruzzese James L; Hess Kenneth R; Zhang Wei; Fidler Isaiah J; Chiao Paul J
Overexpression of tropomysin-related kinase B in metastatic human pancreatic cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(2 Pt 1):440-9.
2005: Lev Dina Chelouche; Kim Sun Jin; Onn Amir; Stone Valerie; Nam Do-Hyun; Yazici Sertac; Fidler Isaiah J; Price Janet E
Inhibition of platelet-derived growth factor receptor signaling restricts the growth of human breast cancer in the bone of nude mice.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(1):306-14.
2005: Cheng Hua; Cenciarelli Carlo; Nelkin Gina; Tsan Rachel; Fan Dominic; Cheng-Mayer Cecilia; Fidler Isaiah J
Molecular mechanism of hTid-1, the human homolog of Drosophila tumor suppressor l(2)Tid, in the regulation of NF-kappaB activity and suppression of tumor growth.
Molecular and cellular biology 2005;25(1):44-59.
2004: Onn Amir; Isobe Takeshi; Wu Wenjuan; Itasaka Satoshi; Shintani Tomoaki; Shibuya Keiko; Kenji Yokoi; O'reilly Michael S; Fidler Isaiah J; Herbst Roy S
Epidermal growth factor receptor tyrosine kinase inhibitor does not improve paclitaxel effect in an orthotopic mouse model of lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(24):8613-9.
2004: Yigitbasi Orhan G; Younes Maher N; Doan Dao; Jasser Samar A; Schiff Bradley A; Bucana Corazon D; Bekele Benjamin N; Fidler Isaiah J; Myers Jeffrey N
Tumor cell and endothelial cell therapy of oral cancer by dual tyrosine kinase receptor blockade.
Cancer research 2004;64(21):7977-84.
2004: Mathew Paul; Thall Peter F; Jones Donnah; Perez Cherie; Bucana Corazon; Troncoso Patricia; Kim Sun-Jin; Fidler Isaiah J; Logothetis Christopher
Platelet-derived growth factor receptor inhibitor imatinib mesylate and docetaxel: a modular phase I trial in androgen-independent prostate cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2004;22(16):3323-9.
2004: Fidler Isaiah J; Ellis Lee M
Neoplastic angiogenesis--not all blood vessels are created equal.
The New England journal of medicine 2004;351(3):215-6.
2004: Kim Sun Jin; Uehara Hisanori; Yazici Sertac; Langley Robert R; He Junqin; Tsan Rachel; Fan Dominic; Killion Jerald J; Fidler Isaiah J
Simultaneous blockade of platelet-derived growth factor-receptor and epidermal growth factor-receptor signaling and systemic administration of paclitaxel as therapy for human prostate cancer metastasis in bone of nude mice.
Cancer research 2004;64(12):4201-8.
2004: Langley Robert R; Fan Dominic; Tsan Rachel Z; Rebhun Robert; He Junqin; Kim Sun-Jin; Fidler Isaiah J
Activation of the platelet-derived growth factor-receptor enhances survival of murine bone endothelial cells.
Cancer research 2004;64(11):3727-30.
2004: Mathew Paul; Fidler Isaiah J; Logothetis Christopher J
Combination docetaxel and platelet-derived growth factor receptor inhibition with imatinib mesylate in prostate cancer.
Seminars in oncology 2004;31(2 Suppl 6):24-9.
2004: Yokoi Kenji; Fidler Isaiah J
Hypoxia increases resistance of human pancreatic cancer cells to apoptosis induced by gemcitabine.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(7):2299-306.
2004: Apte Sachin M; Bucana Corazon D; Killion Jerald J; Gershenson David M; Fidler Isaiah J
Expression of platelet-derived growth factor and activated receptor in clinical specimens of epithelial ovarian cancer and ovarian carcinoma cell lines.
Gynecologic oncology 2004;93(1):78-86.
2004: Apte Sachin M; Fan Dominic; Killion Jerald J; Fidler Isaiah J
Targeting the platelet-derived growth factor receptor in antivascular therapy for human ovarian carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(3):897-908.
2004: Onn Amir; Correa Arlene M; Gilcrease Michael; Isobe Takeshi; Massarelli Erminia; Bucana Corazon D; O'Reilly Michael S; Hong Waun K; Fidler Isaiah J; Putnam Joe B; Herbst Roy S
Synchronous overexpression of epidermal growth factor receptor and HER2-neu protein is a predictor of poor outcome in patients with stage I non-small cell lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(1 Pt 1):136-43.
2004: Bucana Corazon D; Fidler Isaiah J
Bioassay using epidermal keratinocytes to determine phosphorylation status of the epidermal growth factor receptor in distant neoplasms.
International journal of oncology 2004;24(1):19-24.
2004: Fidler Isaiah J
From here to there; a life based on migration. An interview with Isaiah J. Fidler.
The International journal of developmental biology 2004;48(5-6):457-62.
2003: Hwang Rosa F; Yokoi Kenji; Bucana Corazon D; Tsan Rachel; Killion Jerald J; Evans Douglas B; Fidler Isaiah J
Inhibition of platelet-derived growth factor receptor phosphorylation by STI571 (Gleevec) reduces growth and metastasis of human pancreatic carcinoma in an orthotopic nude mouse model.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(17):6534-44.
2003: Onn Amir; Isobe Takeshi; Itasaka Satoshi; Wu Wenjuan; O'Reilly Michael S; Ki Hong Waun; Fidler Isaiah J; Herbst Roy S
Development of an orthotopic model to study the biology and therapy of primary human lung cancer in nude mice.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(15):5532-9.
2003: Kuniyasu Hiroki; Ohmori Hitoshi; Sasaki Takamistu; Sasahira Tomonori; Yoshida Kazuhiro; Kitadai Yasuhiko; Fidler Isaiah J
Production of interleukin 15 by human colon cancer cells is associated with induction of mucosal hyperplasia, angiogenesis, and metastasis.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(13):4802-10.
2003: Holsinger F Christopher; Doan Dao D; Jasser Samar A; Swan Eric A; Greenberg Jayson S; Schiff Bradley A; Bekele B Nebiyou; Younes Maher N; Bucana Corazon D; Fidler Isaiah J; Myers Jeffrey N
Epidermal growth factor receptor blockade potentiates apoptosis mediated by Paclitaxel and leads to prolonged survival in a murine model of oral cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(8):3183-9.
2003: McCarty M F; Bielenberg D R; Nilsson M B; Gershenwald J E; Barnhill R L; Ahearne P; Bucana C D; Fidler I J
Epidermal hyperplasia overlying human melanoma correlates with tumour depth and angiogenesis.
Melanoma research 2003;13(4):379-87.
2003: Kuniyasu Hiroki; Ukai Rinzo; Johnston Dennis; Troncoso Patricia; Fidler Isaiah J; Pettaway Curtis A
The relative mRNA expression levels of matrix metalloproteinase to E-cadherin in prostate biopsy specimens distinguishes organ-confined from advanced prostate cancer at radical prostatectomy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(6):2185-94.
2003: Langley Robert R; Ramirez Karen M; Tsan Rachel Z; Van Arsdall Melissa; Nilsson Monique B; Fidler Isaiah J
Tissue-specific microvascular endothelial cell lines from H-2K(b)-tsA58 mice for studies of angiogenesis and metastasis.
Cancer research 2003;63(11):2971-6.
2003: Weber Kristy L; Doucet Michele; Price Janet E; Baker Cheryl; Kim Sun Jin; Fidler Isaiah J
Blockade of epidermal growth factor receptor signaling leads to inhibition of renal cell carcinoma growth in the bone of nude mice.
Cancer research 2003;63(11):2940-7.
2003: Fidler Isaiah J
The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited.
Nature reviews. Cancer 2003;3(6):453-8.
2003: Fidler Isaiah J
Understanding bone metastases: the key to the effective treatment of prostate cancer.
Clinical advances in hematology & oncology : H&O 2003;1(5):278-9.
2003: Solorzano Carmen C; Hwang Rosa; Baker Cheryl H; Bucana Corazon D; Pisters Peter W; Evans Douglas B; Killion Jerald J; Fidler Isaiah J
Administration of optimal biological dose and schedule of interferon alpha combined with gemcitabine induces apoptosis in tumor-associated endothelial cells and reduces growth of human pancreatic carcinoma implanted orthotopically in nude mice.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(5):1858-67.
2003: Fidler Isaiah J; Kripke Margaret L
Genomic analysis of primary tumors does not address the prevalence of metastatic cells in the population.
Nature genetics 2003;34(1):23; author reply 25.
2003: Ozawa Shutaro; Lu Weixin; Bucana Corazon D; Kanayama Hiro-Omi; Shinohara Hisashi; Fidler Isaiah J; Dong Zhongyun
Regression of primary murine colon cancer and occult liver metastasis by intralesional injection of lyophilized preparation of insect cells producing murine interferon-beta.
International journal of oncology 2003;22(5):977-84.
2003: Lu Weixin; Su Jindong; Kim Lee Su; Bucana Corazon D; Donawho Cherrie; He Junqing; Fidler Isaiah J; Dong Zhongyun
Active specific immunotherapy against occult brain metastasis.
Cancer research 2003;63(6):1345-50.
2003: Uehara Hisanori; Kim Sun Jin; Karashima Takashi; Shepherd David L; Fan Dominic; Tsan Rachel; Killion Jerald J; Logothetis Christopher; Mathew Paul; Fidler Isaiah J
Effects of blocking platelet-derived growth factor-receptor signaling in a mouse model of experimental prostate cancer bone metastases.
Journal of the National Cancer Institute 2003;95(6):458-70.
2003: Kim Sun-Jin; Uehara Hisanori; Karashima Takashi; Shepherd David L; Killion Jerald J; Fidler Isaiah J
Blockade of epidermal growth factor receptor signaling in tumor cells and tumor-associated endothelial cells for therapy of androgen-independent human prostate cancer growing in the bone of nude mice.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(3):1200-10.
2003: Fidler Isaiah J; Yoneda Junya; Herrera Carlos; Wood Jeanette; Xu Lei
Specific keynote: molecular determinants of angiogenesis in ovarian cancer.
Gynecologic oncology 2003;88(1 Pt 2):S29-36; discussion S37-42.
2002: Fidler Isaiah J
The organ microenvironment and cancer metastasis.
Differentiation; research in biological diversity 2002;70(9-10):498-505.
2002: Onn Amir; Fidler Isaiah J
Metastatic potential of human neoplasms.
In vivo (Athens, Greece) 2002;16(6):423-9.
2002: Takahashi Yutaka; Kitadai Yasuhiko; Ellis Lee M; Bucana Corazon D; Fidler Isaiah J; Mai Masayoshi
Multiparametric in situ mRNA hybridization analysis of gastric biopsies predicts lymph node metastasis in patients with gastric carcinoma.
Japanese journal of cancer research : Gann 2002;93(11):1258-65.
2002: Kedar Daniel; Baker Cheryl H; Killion Jerald J; Dinney Colin P N; Fidler Isaiah J
Blockade of the epidermal growth factor receptor signaling inhibits angiogenesis leading to regression of human renal cell carcinoma growing orthotopically in nude mice.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(11):3592-600.
2002: McGary Eric C; Weber Kristy; Mills Lisa; Doucet Michelle; Lewis Valerie; Lev Dina Chelouche; Fidler Isaiah J; Bar-Eli Menashe
Inhibition of platelet-derived growth factor-mediated proliferation of osteosarcoma cells by the novel tyrosine kinase inhibitor STI571.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(11):3584-91.
2002: Huang Samuel F; Kim Sun-Jin; Lee Anh T; Karashima Takashi; Bucana Cora; Kedar Daniel; Sweeney Paul; Mian Badar; Fan Dominic; Shepherd David; Fidler Isaiah J; Dinney Colin P; Killion Jerald J
Inhibition of growth and metastasis of orthotopic human prostate cancer in athymic mice by combination therapy with pegylated interferon-alpha-2b and docetaxel.
Cancer research 2002;62(20):5720-6.
2002: Fan Dominic; Liaw Amy; Denkins Yvonne M; Collins James H; Van Arsdall Melissa; Chang Jolie Lien; Chakrabarty Subhas; Nguyen Dieuthu; Kruzel Ewa; Fidler Isaiah J
Type-1 transforming growth factor-beta differentially modulates tumoricidal activity of murine peritoneal macrophages against metastatic variants of the B16 murine melanoma.
Journal of experimental therapeutics & oncology 2002;2(5):286-97.
2002: Baker Cheryl H; Kedar Daniel; McCarty Marya F; Tsan Rachel; Weber Kristen L; Bucana Corazon D; Fidler Isaiah J
Blockade of epidermal growth factor receptor signaling on tumor cells and tumor-associated endothelial cells for therapy of human carcinomas.
The American journal of pathology 2002;161(3):929-38.
2002: Huang Suyun; Van Arsdall Melissa; Tedjarati Sean; McCarty Marya; Wu Wenjuan; Langley Robert; Fidler Isaiah J
Contributions of stromal metalloproteinase-9 to angiogenesis and growth of human ovarian carcinoma in mice.
Journal of the National Cancer Institute 2002;94(15):1134-42.
2002: Myers Jeffrey N; Holsinger F Christopher; Bekele B Nebiyou; Li Emily; Jasser Samar A; Killion Jerald J; Fidler Isaiah J
Targeted molecular therapy for oral cancer with epidermal growth factor receptor blockade: a preliminary report.
Archives of otolaryngology--head & neck surgery 2002;128(8):875-9.
2002: Lu Weixin; Dong Zhongyun; Donawho Cherrie; Fidler Isaiah J
Specific immunotherapy against occult cancer metastases.
International journal of cancer. Journal international du cancer 2002;100(4):480-5.
2002: Tedjarati Sean; Baker Cheryl H; Apte Sachin; Huang Suyun; Wolf Judith K; Killion Jerald J; Fidler Isaiah J
Synergistic therapy of human ovarian carcinoma implanted orthotopically in nude mice by optimal biological dose of pegylated interferon alpha combined with paclitaxel.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(7):2413-22.
2002: Studeny Matus; Marini Frank C; Champlin Richard E; Zompetta Claudia; Fidler Isaiah J; Andreeff Michael
Bone marrow-derived mesenchymal stem cells as vehicles for interferon-beta delivery into tumors.
Cancer research 2002;62(13):3603-8.
2002: McCarty Marya F; Baker Cheryl H; Bucana Corazon D; Fidler Isaiah J
Quantitative and qualitative in vivo angiogenesis assay.
International journal of oncology 2002;21(1):5-10.
2002: Fan Dominic; Yano Seiji; Shinohara Hisashi; Solorzano Carmen; Van Arsdall Melissa; Bucana Corazon D; Pathak Sen; Kruzel Ewa; Herbst Roy S; Onn Amir; Roach Jennifer S; Onda Masanori; Wang Qing-cheng; Pastan Ira; Fidler Isaiah J
Targeted therapy against human lung cancer in nude mice by high-affinity recombinant antimesothelin single-chain Fv immunotoxin.
Molecular cancer therapeutics 2002;1(8):595-600.
2002: Gershenwald Jeffrey E; Fidler Isaiah J
Cancer. Targeting lymphatic metastasis.
Science (New York, N.Y.) 2002;296(5574):1811-2.
2002: Fidler Isaiah J
Critical determinants of metastasis.
Seminars in cancer biology 2002;12(2):89-96.
2002: Huang Suyun; Bucana Corazon D; Van Arsdall Melissa; Fidler Isaiah J
Stat1 negatively regulates angiogenesis, tumorigenicity and metastasis of tumor cells.
Oncogene 2002;21(16):2504-12.
2002: Baker Cheryl H; Solorzano Carmen C; Fidler Isaiah J
Blockade of vascular endothelial growth factor receptor and epidermal growth factor receptor signaling for therapy of metastatic human pancreatic cancer.
Cancer research 2002;62(7):1996-2003.
2002: Fidler Isaiah J; Yano Seiji; Zhang Ruo-Dan; Fujimaki Takahashi; Bucana Corazon D
The seed and soil hypothesis: vascularisation and brain metastases.
The lancet oncology 2002;3(1):53-7.
2002: Myers Jeffrey N; Holsinger F Christopher; Jasser Samar A; Bekele B Nebiyou; Fidler Isaiah J
An orthotopic nude mouse model of oral tongue squamous cell carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(1):293-8.
2002: Herrera Carlos A; Xu Lei; Bucana Corazon D; Silva El Vio G; Hess Kenneth R; Gershenson David M; Fidler Isaiah J
Expression of metastasis-related genes in human epithelial ovarian tumors.
International journal of oncology 2002;20(1):5-13.
2002: McCarty Marya F; Bielenberg Diane; Donawho Cherrie; Bucana Corazon D; Fidler Isaiah J
Evidence for the causal role of endogenous interferon-alpha/beta in the regulation of angiogenesis, tumorigenicity, and metastasis of cutaneous neoplasms.
Clinical & experimental metastasis 2002;19(7):609-15.
2001: Solorzano C C; Baker C H; Bruns C J; Killion J J; Ellis L M; Wood J; Fidler I J
Inhibition of growth and metastasis of human pancreatic cancer growing in nude mice by PTK 787/ZK222584, an inhibitor of the vascular endothelial growth factor receptor tyrosine kinases.
Cancer biotherapy & radiopharmaceuticals 2001;16(5):359-70.
2001: Kuniyasu H; Abbruzzese J L; Cleary K R; Fidler I J
Induction of ductal and stromal hyperplasia by basic fibroblast growth factor produced by human pancreatic carcinoma.
International journal of oncology 2001;19(4):681-5.
2001: Kuniyasu H; Yasui W; Pettaway C A; Yano S; Oue N; Tahara E; Fidler I J
Interferon-alpha prevents selection of doxorubicin-resistant undifferentiated-androgen-insensitive metastatic human prostate cancer cells.
The Prostate 2001;49(1):19-29.
2001: Solorzano C C; Baker C H; Tsan R; Traxler P; Cohen P; Buchdunger E; Killion J J; Fidler I J
Optimization for the blockade of epidermal growth factor receptor signaling for therapy of human pancreatic carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(8):2563-72.
2001: Huang S; Pettaway C A; Uehara H; Bucana C D; Fidler I J
Blockade of NF-kappaB activity in human prostate cancer cells is associated with suppression of angiogenesis, invasion, and metastasis.
Oncogene 2001;20(31):4188-97.
2001: Baker C H; Solorzano C C; Fidler I J
Angiogenesis and cancer metastasis: antiangiogenic therapy of human pancreatic adenocarcinoma.
International journal of clinical oncology / Japan Society of Clinical Oncology 2001;6(2):59-65.
2001: Ozawa S; Shinohara H; Kanayama H O; Bruns C J; Bucana C D; Ellis L M; Davis D W; Fidler I J
Suppression of angiogenesis and therapy of human colon cancer liver metastasis by systemic administration of interferon-alpha.
Neoplasia (New York, N.Y.) 2001;3(2):154-64.
2001: Slaton J W; Inoue K; Perrotte P; El-Naggar A K; Swanson D A; Fidler I J; Dinney C P
Expression levels of genes that regulate metastasis and angiogenesis correlate with advanced pathological stage of renal cell carcinoma.
The American journal of pathology 2001;158(2):735-43.
2001: Kim S J; Uehara H; Karashima T; Mccarty M; Shih N; Fidler I J
Expression of interleukin-8 correlates with angiogenesis, tumorigenicity, and metastasis of human prostate cancer cells implanted orthotopically in nude mice.
Neoplasia (New York, N.Y.) 2001;3(1):33-42.
2001: Fidler I J
Regulation of neoplastic angiogenesis.
Journal of the National Cancer Institute. Monographs 2001;(28):10-4.
2000: Yano S; Shinohara H; Herbst R S; Kuniyasu H; Bucana C D; Ellis L M; Fidler I J
Production of experimental malignant pleural effusions is dependent on invasion of the pleura and expression of vascular endothelial growth factor/vascular permeability factor by human lung cancer cells.
The American journal of pathology 2000;157(6):1893-903.
2000: Kuniyasu H; Yasui W; Shinohara H; Yano S; Ellis L M; Wilson M R; Bucana C D; Rikita T; Tahara E; Fidler I J
Induction of angiogenesis by hyperplastic colonic mucosa adjacent to colon cancer.
The American journal of pathology 2000;157(5):1523-35.
2000: Huang S; Robinson J B; Deguzman A; Bucana C D; Fidler I J
Blockade of nuclear factor-kappaB signaling inhibits angiogenesis and tumorigenicity of human ovarian cancer cells by suppressing expression of vascular endothelial growth factor and interleukin 8.
Cancer research 2000;60(19):5334-9.
2000: Shinohara H; Fan D; Ozawa S; Yano S; Van Arsdell M; Viner J L; Beers R; Pastan I; Fidler I J
Site-specific expression of transferrin receptor by human colon cancer cells directly correlates with eradication by antitransferrin recombinant immunotoxin.
International journal of oncology 2000;17(4):643-51.
2000: Yano S; Shinohara H; Herbst R S; Kuniyasu H; Bucana C D; Ellis L M; Davis D W; McConkey D J; Fidler I J
Expression of vascular endothelial growth factor is necessary but not sufficient for production and growth of brain metastasis.
Cancer research 2000;60(17):4959-67.
2000: Xu L; Fidler I J
Acidic pH-induced elevation in interleukin 8 expression by human ovarian carcinoma cells.
Cancer research 2000;60(16):4610-6.
2000: Huang S; DeGuzman A; Bucana C D; Fidler I J
Nuclear factor-kappaB activity correlates with growth, angiogenesis, and metastasis of human melanoma cells in nude mice.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(6):2573-81.
2000: Kuniyasu H; Troncoso P; Johnston D; Bucana C D; Tahara E; Fidler I J; Pettaway C A
Relative expression of type IV collagenase, E-cadherin, and vascular endothelial growth factor/vascular permeability factor in prostatectomy specimens distinguishes organ-confined from pathologically advanced prostate cancers.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(6):2295-308.
2000: Bruns C J; Solorzano C C; Harbison M T; Ozawa S; Tsan R; Fan D; Abbruzzese J; Traxler P; Buchdunger E; Radinsky R; Fidler I J
Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma.
Cancer research 2000;60(11):2926-35.
2000: Kumar R; Xie K; Eue I; Dong Z; Killion J J; Fidler I J
Differential regulation of type IV collagenases and metalloelastase in murine macrophages by the synthetic bacterial lipopeptide JBT 3002.
International journal of immunopharmacology 2000;22(6):431-43.
2000: Fidler I J; Singh R K; Yoneda J; Kumar R; Xu L; Dong Z; Bielenberg D R; McCarty M; Ellis L M
Critical determinants of neoplastic angiogenesis.
Cancer journal (Sudbury, Mass.) 2000;6 Suppl 3():S225-36.
2000: Shinohara H; Bucana C D; Killion J J; Fidler I J
Intensified regression of colon cancer liver metastases in mice treated with irinotecan and the immunomodulator JBT 3002.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2000;23(3):321-31.
2000: Fidler I J
Angiogenesis and cancer metastasis.
Cancer journal (Sudbury, Mass.) 2000;6 Suppl 2():S134-41.
2000: Huang S; DeGuzman A; Bucana C D; Fidler I J
Level of interleukin-8 expression by metastatic human melanoma cells directly correlates with constitutive NF-kappaB activity.
Cytokines, cellular & molecular therapy 2000;6(1):9-17.
2000: Yano S; Herbst R S; Shinohara H; Knighton B; Bucana C D; Killion J J; Wood J; Fidler I J
Treatment for malignant pleural effusion of human lung adenocarcinoma by inhibition of vascular endothelial growth factor receptor tyrosine kinase phosphorylation.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(3):957-65.
2000: Herbst R S; Yano S; Kuniyasu H; Khuri F R; Bucana C D; Guo F; Liu D; Kemp B; Lee J J; Hong W K; Fidler I J
Differential expression of E-cadherin and type IV collagenase genes predicts outcome in patients with stage I non-small cell lung carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(3):790-7.
2000: Yang J; Boerm M; McCarty M; Bucana C; Fidler I J; Zhuang Y; Su B
Mekk3 is essential for early embryonic cardiovascular development.
Nature genetics 2000;24(3):309-13.
2000: Shinohara H; Yano S; Bucana C D; Fidler I J
Induction of chemokine secretion and enhancement of contact-dependent macrophage cytotoxicity by engineered expression of granulocyte-macrophage colony-stimulating factor in human colon cancer cells.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(5):2728-37.
2000: Xu L; Yoneda J; Herrera C; Wood J; Killion J J; Fidler I J
Inhibition of malignant ascites and growth of human ovarian carcinoma by oral administration of a potent inhibitor of the vascular endothelial growth factor receptor tyrosine kinases.
International journal of oncology 2000;16(3):445-54.
2000: Bruns C J; Shinohara H; Harbison M T; Davis D W; Nelkin G; Killion J J; McConkey D J; Dong Z; Fidler I J
Therapy of human pancreatic carcinoma implants by irinotecan and the oral immunomodulator JBT 3002 is associated with enhanced expression of inducible nitric oxide synthase in tumor-infiltrating macrophages.
Cancer research 2000;60(1):2-7.
1999: Shi Q; Abbruzzese J L; Huang S; Fidler I J; Xiong Q; Xie K
Constitutive and inducible interleukin 8 expression by hypoxia and acidosis renders human pancreatic cancer cells more tumorigenic and metastatic.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(11):3711-21.
1999: Xu L; Xie K; Mukaida N; Matsushima K; Fidler I J
Hypoxia-induced elevation in interleukin-8 expression by human ovarian carcinoma cells.
Cancer research 1999;59(22):5822-9.
1999: Slaton J W; Perrotte P; Inoue K; Dinney C P; Fidler I J
Interferon-alpha-mediated down-regulation of angiogenesis-related genes and therapy of bladder cancer are dependent on optimization of biological dose and schedule.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(10):2726-34.
1999: Lu W; Fidler I J; Dong Z
Eradication of primary murine fibrosarcomas and induction of systemic immunity by adenovirus-mediated interferon beta gene therapy.
Cancer research 1999;59(20):5202-8.
1999: Multani A S; Ozen M; Sen S; Mandal A K; Price J E; Fan D; Radinsky R; Ali-Osman F; Von Eschenbach A C; Fidler I J; Pathak S
Amplification of telomeric DNA directly correlates with metastatic potential of human and murine cancers of various histological origin.
International journal of oncology 1999;15(3):423-9.
1999: Shinohara H; Killion J J; Bucana C D; Yano S; Fidler I J
Oral administration of the immunomodulator JBT-3002 induces endogenous interleukin 15 in intestinal macrophages for protection against irinotecan-mediated destruction of intestinal epithelium.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(8):2148-56.
1999: Yoneda J; Killion J J; Bucana C D; Fidler I J
Angiogenesis and growth of murine colon carcinoma are dependent on infiltrating leukocytes.
Cancer biotherapy & radiopharmaceuticals 1999;14(3):221-30.
1999: Bielenberg D R; McCarty M F; Bucana C D; Yuspa S H; Morgan D; Arbeit J M; Ellis L M; Cleary K R; Fidler I J
Expression of interferon-beta is associated with growth arrest of murine and human epidermal cells.
The Journal of investigative dermatology 1999;112(5):802-9.
1999: Bruns C J; Harbison M T; Kuniyasu H; Eue I; Fidler I J
In vivo selection and characterization of metastatic variants from human pancreatic adenocarcinoma by using orthotopic implantation in nude mice.
Neoplasia (New York, N.Y.) 1999;1(1):50-62.
1999: Balbay M D; Pettaway C A; Kuniyasu H; Inoue K; Ramirez E; Li E; Fidler I J; Dinney C P
Highly metastatic human prostate cancer growing within the prostate of athymic mice overexpresses vascular endothelial growth factor.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(4):783-9.
1999: Bielenberg D R; Bucana C D; Sanchez R; Mulliken J B; Folkman J; Fidler I J
Progressive growth of infantile cutaneous hemangiomas is directly correlated with hyperplasia and angiogenesis of adjacent epidermis and inversely correlated with expression of the endogenous angiogenesis inhibitor, IFN-beta.
International journal of oncology 1999;14(3):401-8.
1999: Dong Z; Greene G; Pettaway C; Dinney C P; Eue I; Lu W; Bucana C D; Balbay M D; Bielenberg D; Fidler I J
Suppression of angiogenesis, tumorigenicity, and metastasis by human prostate cancer cells engineered to produce interferon-beta.
Cancer research 1999;59(4):872-9.
1999: Kuniyasu H; Ellis L M; Evans D B; Abbruzzese J L; Fenoglio C J; Bucana C D; Cleary K R; Tahara E; Fidler I J
Relative expression of E-cadherin and type IV collagenase genes predicts disease outcome in patients with resectable pancreatic carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(1):25-33.
1999: Kumar R; Yoneda J; Fidler I J; Dong Z
GM-CSF-transduced B16 melanoma cells are highly susceptible to lysis by normal murine macrophages and poorly tumorigenic in immune-compromised mice.
Journal of leukocyte biology 1999;65(1):102-8.
1999: Kanayama H; Yano S; Kim S J; Ozawa S; Ellis L M; Fidler I J
Expression of vascular endothelial growth factor by human renal cancer cells enhances angiogenesis of primary tumors and production of ascites but not metastasis to the lungs in nude mice.
Clinical & experimental metastasis 1999;17(10):831-40.
1999: Fidler I J; Schackert G; Zhang R D; Radinsky R; Fujimaki T
The biology of melanoma brain metastasis.
Cancer metastasis reviews 1999;18(3):387-400.
1998: Xu L; Xie K; Fidler I J
Therapy of human ovarian cancer by transfection with the murine interferon beta gene: role of macrophage-inducible nitric oxide synthase.
Human gene therapy 1998;9(18):2699-708.
1998: Bielenberg D R; Bucana C D; Sanchez R; Donawho C K; Kripke M L; Fidler I J
Molecular regulation of UVB-induced cutaneous angiogenesis.
The Journal of investigative dermatology 1998;111(5):864-72.
1998: Bielenberg D R; Fidler I J; Bucana C D
Constitutive expression of interferon beta in differentiated epithelial cells exposed to environmental stimuli.
Cancer biotherapy & radiopharmaceuticals 1998;13(5):375-82.
1998: Eue I; Kumar R; Dong Z; Killion J J; Fidler I J
Induction of nitric oxide production and tumoricidal properties in murine macrophages by a new synthetic lipopeptide JBT3002 encapsulated in liposomes.
Journal of immunotherapy (Hagerstown, Md. : 1997) 1998;21(5):340-51.
1998: Shinohara H; Killion J J; Kuniyasu H; Kumar R; Fidler I J
Prevention of intestinal toxic effects and intensification of irinotecan's therapeutic efficacy against murine colon cancer liver metastases by oral administration of the lipopeptide JBT 3002.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(9):2053-63.
1998: Dong Z; Yoneda J; Kumar R; Fidler I J
Angiostatin-mediated suppression of cancer metastases by primary neoplasms engineered to produce granulocyte/macrophage colony-stimulating factor.
The Journal of experimental medicine 1998;188(4):755-63.
1998: Dong Z; Killion J J; Kumar R; Eue I; Yang X; Lu W; Su B; Fidler I J
Activation of cytokine production, tumoricidal properties, and tyrosine phosphorylation of MAPKs in human monocytes by a new synthetic lipopeptide, JBT3002.
Journal of leukocyte biology 1998;63(6):766-74.
1998: Dong Z; Juang S H; Kumar R; Eue I; Xie K; Bielenberg D; Lu W; Bucana C; Yang X; Fidler I J
Suppression of tumorigenicity and metastasis in murine UV-2237 fibrosarcoma cells by infection with a retroviral vector harboring the interferon-beta gene.
Cancer immunology, immunotherapy : CII 1998;46(3):137-46.
1998: Fidler I J; Kumar R; Bielenberg D R; Ellis L M
Molecular determinants of angiogenesis in cancer metastasis.
The cancer journal from Scientific American 1998;4 Suppl 1():S58-66.
1998: Juang S H; Xie K; Xu L; Shi Q; Wang Y; Yoneda J; Fidler I J
Suppression of tumorigenicity and metastasis of human renal carcinoma cells by infection with retroviral vectors harboring the murine inducible nitric oxide synthase gene.
Human gene therapy 1998;9(6):845-54.
1998: Kumar R; Yoneda J; Bucana C D; Fidler I J
Regulation of distinct steps of angiogenesis by different angiogenic molecules.
International journal of oncology 1998;12(4):749-57.
1998: Xie K; Fidler I J
Therapy of cancer metastasis by activation of the inducible nitric oxide synthase.
Cancer metastasis reviews 1998;17(1):55-75.
1998: Yoneda J; Kuniyasu H; Crispens M A; Price J E; Bucana C D; Fidler I J
Expression of angiogenesis-related genes and progression of human ovarian carcinomas in nude mice.
Journal of the National Cancer Institute 1998;90(6):447-54.
1998: Dinney C P; Bielenberg D R; Perrotte P; Reich R; Eve B Y; Bucana C D; Fidler I J
Inhibition of basic fibroblast growth factor expression, angiogenesis, and growth of human bladder carcinoma in mice by systemic interferon-alpha administration.
Cancer research 1998;58(4):808-14.
1998: Kumar R; Fidler I J
Angiogenic molecules and cancer metastasis.
In vivo (Athens, Greece) 1998;12(1):27-34.
1998: Killion J J; Radinsky R; Fidler I J
Orthotopic models are necessary to predict therapy of transplantable tumors in mice.
Cancer metastasis reviews 1998;17(3):279-84.
1998: Kumar R; Kuniyasu H; Bucana C D; Wilson M R; Fidler I J
Spatial and temporal expression of angiogenic molecules during tumor growth and progression.
Oncology research 1998;10(6):301-11.
1997: Xie K; Bielenberg D; Huang S; Xu L; Salas T; Juang S H; Dong Z; Fidler I J
Abrogation of tumorigenicity and metastasis of murine and human tumor cells by transfection with the murine IFN-beta gene: possible role of nitric oxide.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(12 Pt 1):2283-94.
1997: Kumar R; Eue I; Dong Z; Killion J J; Fidler I J
Expression of inflammatory cytokines by murine macrophages activated with a new synthetic lipopeptide JT3002.
Cancer biotherapy & radiopharmaceuticals 1997;12(5):333-40.
1997: Nemeth M A; Wilson M R; Fidler I J; Pathak S
Increasing metastatic potential is associated with induced chromosome 14 translocations in a previously nonmetastatic murine melanoma cell line.
Cancer genetics and cytogenetics 1997;98(2):119-25.
1997: Yoon S S; Fidler I J; Beltran P J; Bucana C D; Wang Y F; Fan D
Intratumoral heterogeneity for and epigenetic modulation of mdr-1 expression in murine melanoma.
Melanoma research 1997;7(4):275-87.
1997: Xie K; Wang Y; Huang S; Xu L; Bielenberg D; Salas T; McConkey D J; Jiang W; Fidler I J
Nitric oxide-mediated apoptosis of K-1735 melanoma cells is associated with downregulation of Bcl-2.
Oncogene 1997;15(7):771-9.
1997: Juang S H; Xie K; Xu L; Wang Y; Yoneda J; Fidler I J
Use of retroviral vectors encoding murine inducible nitric oxide synthase gene to suppress tumorigenicity and cancer metastasis of murine melanoma.
Cancer biotherapy & radiopharmaceuticals 1997;12(3):167-75.
1997: Greene G F; Kitadai Y; Pettaway C A; von Eschenbach A C; Bucana C D; Fidler I J
Correlation of metastasis-related gene expression with metastatic potential in human prostate carcinoma cells implanted in nude mice using an in situ messenger RNA hybridization technique.
The American journal of pathology 1997;150(5):1571-82.
1997: Dong Z; Kumar R; Yang X; Fidler I J
Macrophage-derived metalloelastase is responsible for the generation of angiostatin in Lewis lung carcinoma.
Cell 1997;88(6):801-10.
1997: Xie K; Huang S; Dong Z; Juang S H; Wang Y; Fidler I J
Destruction of bystander cells by tumor cells transfected with inducible nitric oxide (NO) synthase gene.
Journal of the National Cancer Institute 1997;89(6):421-7.
1997: Beltran P J; Fan D; Fidler I J; O'Brian C A
Chemosensitization of cancer cells by the staurosporine derivative CGP 41251 in association with decreased P-glycoprotein phosphorylation.
Biochemical pharmacology 1997;53(2):245-7.
1996: Killion J J; Bucana C D; Radinsky R; Dong Z; O'Reilly T; Bilbe G; Tarcsay L; Fidler I J
Maintenance of intestinal epithelium structural integrity and mucosal leukocytes during chemotherapy by oral administration of muramyl tripeptide phosphatidylethanolamine.
Cancer biotherapy & radiopharmaceuticals 1996;11(6):363-71.
1996: Ellis L M; Fidler I J
Angiogenesis and metastasis.
European journal of cancer (Oxford, England : 1990) 1996;32A(14):2451-60.
1996: Kumar R; Dong Z; Fidler I J
Differential regulation of metalloelastase activity in murine peritoneal macrophages by granulocyte-macrophage colony-stimulating factor and macrophage colony-stimulating factor.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(11):5104-11.
1996: Dave B J; Singh R; Fidler I J; Pathak S
Chromosome 14 alteration is associated with increased collagenase expression and the metastatic potential of murine melanomas.
Cancer genetics and cytogenetics 1996;92(1):66-72.
1996: Kitadai Y; Ellis L M; Tucker S L; Greene G F; Bucana C D; Cleary K R; Takahashi Y; Tahara E; Fidler I J
Multiparametric in situ mRNA hybridization analysis to predict disease recurrence in patients with colon carcinoma.
The American journal of pathology 1996;149(5):1541-51.
1996: Xie K; Huang S; Wang Y; Beltran P J; Juang S H; Dong Z; Reed J C; McDonnell T J; McConkey D J; Fidler I J
Bcl-2 protects cells from cytokine-induced nitric-oxide-dependent apoptosis.
Cancer immunology, immunotherapy : CII 1996;43(2):109-15.
1996: Fujimaki T; Price J E; Fan D; Bucana C D; Itoh K; Kirino T; Fidler I J
Selective growth of human melanoma cells in the brain parenchyma of nude mice.
Melanoma research 1996;6(5):363-71.
1996: Kitadai Y; Radinsky R; Bucana C D; Takahashi Y; Xie K; Tahara E; Fidler I J
Regulation of carcinoembryonic antigen expression in human colon carcinoma cells by the organ microenvironment.
The American journal of pathology 1996;149(4):1157-66.
1996: Pettaway C A; Pathak S; Greene G; Ramirez E; Wilson M R; Killion J J; Fidler I J
Selection of highly metastatic variants of different human prostatic carcinomas using orthotopic implantation in nude mice.
Clinical cancer research : an official journal of the American Association for Cancer Research 1996;2(9):1627-36.
1996: Singh R K; Gutman M; Llansa N; Fidler I J
Interferon-beta prevents the upregulation of interleukin-8 expression in human melanoma cells.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1996;16(8):577-84.
1996: Xie K; Dong Z; Fidler I J
Activation of nitric oxide synthase gene for inhibition of cancer metastasis.
Journal of leukocyte biology 1996;59(6):797-803.
1996: Anzai H; Kitadai Y; Bucana C D; Sanchez R; Omoto R; Fidler I J
Intratumoral heterogeneity and inverse correlation between expression of E-cadherin and collagenase type IV in human gastric carcinomas.
Differentiation; research in biological diversity 1996;60(2):119-27.
1996: Fidler I J
Critical determinants of melanoma metastasis.
The journal of investigative dermatology. Symposium proceedings / the Society for Investigative Dermatology, Inc. [and] European Society for Dermatological Research 1996;1(2):203-8.
1996: Singh R K; Llansa N; Bucana C D; Sanchez R; Koura A; Fidler I J
Cell density-dependent regulation of basic fibroblast growth factor expression in human renal cell carcinoma cells.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1996;7(3):397-404.
1996: Singh R K; Fidler I J
Regulation of tumor angiogenesis by organ-specific cytokines.
Current topics in microbiology and immunology 1996;213 ( Pt 2)():1-11.
1996: Takahashi Y; Ellis L M; Wilson M R; Bucana C D; Kitadai Y; Fidler I J
Progressive upregulation of metastasis-related genes in human colon cancer cells implanted into the cecum of nude mice.
Oncology research 1996;8(4):163-9.
1995: Dong Z; Yang X; Xie K; Juang S H; Llansa N; Fidler I J
Activation of inducible nitric oxide synthase gene in murine macrophages requires protein phosphatases 1 and 2A activities.
Journal of leukocyte biology 1995;58(6):725-32.
1995: Fidler I J
Modulation of the organ microenvironment for treatment of cancer metastasis.
Journal of the National Cancer Institute 1995;87(21):1588-92.
1995: Kitadai Y; Bucana C D; Ellis L M; Anzai H; Tahara E; Fidler I J
In situ mRNA hybridization technique for analysis of metastasis-related genes in human colon carcinoma cells.
The American journal of pathology 1995;147(5):1238-47.
1995: Kitadai Y; Ellis L M; Takahashi Y; Bucana C D; Anzai H; Tahara E; Fidler I J
Multiparametric in situ messenger RNA hybridization analysis to detect metastasis-related genes in surgical specimens of human colon carcinomas.
Clinical cancer research : an official journal of the American Association for Cancer Research 1995;1(10):1095-102.
1995: Dinney C P; Fishbeck R; Singh R K; Eve B; Pathak S; Brown N; Xie B; Fan D; Bucana C D; Fidler I J
Isolation and characterization of metastatic variants from human transitional cell carcinoma passaged by orthotopic implantation in athymic nude mice.
The Journal of urology 1995;154(4):1532-8.
1995: Xie K; Huang S; Dong Z; Gutman M; Fidler I J
Direct correlation between expression of endogenous inducible nitric oxide synthase and regression of M5076 reticulum cell sarcoma hepatic metastases in mice treated with liposomes containing lipopeptide CGP 31362.
Cancer research 1995;55(14):3123-31.
1995: Gutman M; Singh R K; Xie K; Bucana C D; Fidler I J
Regulation of interleukin-8 expression in human melanoma cells by the organ environment.
Cancer research 1995;55(11):2470-5.
1995: Gutman M; Beltran P J; Fan D; Delworth M G; Singh R K; Wilson M R; Fidler I J
Treatment of nude mice with 4-amidinoindan -1- one2 '- amidinohydrazone, a new S-adenosylmethionine decarboxylase inhibitor, delays growth and inhibits metastasis of human melanoma cells.
Melanoma research 1995;5(3):147-54.
1995: Dinney C P; Tanguay S; Bucana C D; Eve B Y; Fidler I J
Intravesical liposomal muramyl tripeptide phosphatidylethanolamine treatment of human bladder carcinoma growing in nude mice.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1995;15(6):585-92.
1995: Singh R K; Gutman M; Bucana C D; Sanchez R; Llansa N; Fidler I J
Interferons alpha and beta down-regulate the expression of basic fibroblast growth factor in human carcinomas.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(10):4562-6.
1995: Xie K; Huang S; Dong Z; Juang S H; Gutman M; Xie Q W; Nathan C; Fidler I J
Transfection with the inducible nitric oxide synthase gene suppresses tumorigenicity and abrogates metastasis by K-1735 murine melanoma cells.
The Journal of experimental medicine 1995;181(4):1333-43.
1995: Radinsky R; Risin S; Fan D; Dong Z; Bielenberg D; Bucana C D; Fidler I J
Level and function of epidermal growth factor receptor predict the metastatic potential of human colon carcinoma cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 1995;1(1):19-31.
1995: Radinsky R; Beltran P J; Tsan R; Zhang R; Cone R D; Fidler I J
Transcriptional induction of the melanocyte-stimulating hormone receptor in brain metastases of murine K-1735 melanoma.
Cancer research 1995;55(1):141-8.
1995: Killion J J; Beltran P; O'Brian C A; Yoon S S; Fan D; Wilson M R; Fidler I J
The antitumor activity of doxorubicin against drug-resistant murine carcinoma is enhanced by oral administration of a synthetic staurosporine analogue, CGP 41251.
Oncology research 1995;7(9):453-9.
1994: Tanguay S; Bucana C D; Wilson M R; Fidler I J; von Eschenbach A C; Killion J J
In vivo modulation of macrophage tumoricidal activity by oral administration of the liposome-encapsulated macrophage activator CGP 19835A.
Cancer research 1994;54(22):5882-8.
1994: Huang S; Singh R K; Xie K; Gutman M; Berry K K; Bucana C D; Fidler I J; Bar-Eli M
Expression of the JE/MCP-1 gene suppresses metastatic potential in murine colon carcinoma cells.
Cancer immunology, immunotherapy : CII 1994;39(4):231-8.
1994: Fidler I J; Ellis L M
The implications of angiogenesis for the biology and therapy of cancer metastasis.
Cell 1994;79(2):185-8.
1994: Singh R K; Bucana C D; Gutman M; Fan D; Wilson M R; Fidler I J
Organ site-dependent expression of basic fibroblast growth factor in human renal cell carcinoma cells.
The American journal of pathology 1994;145(2):365-74.
1994: Gohji K; Fidler I J; Tsan R; Radinsky R; von Eschenbach A C; Tsuruo T; Nakajima M
Human recombinant interferons-beta and -gamma decrease gelatinase production and invasion by human KG-2 renal-carcinoma cells.
International journal of cancer. Journal international du cancer 1994;58(3):380-4.
1994: Radinsky R; Fidler I J; Price J E; Esumi N; Tsan R; Petty C M; Bucana C D; Bar-Eli M
Terminal differentiation and apoptosis in experimental lung metastases of human osteogenic sarcoma cells by wild type p53.
Oncogene 1994;9(7):1877-83.
1994: Singh R K; Gutman M; Radinsky R; Bucana C D; Fidler I J
Expression of interleukin 8 correlates with the metastatic potential of human melanoma cells in nude mice.
Cancer research 1994;54(12):3242-7.
1994: Fidler I J; Wilmanns C; Staroselsky A; Radinsky R; Dong Z; Fan D
Modulation of tumor cell response to chemotherapy by the organ environment.
Cancer metastasis reviews 1994;13(2):209-22.
1994: Dong Z; Radinsky R; Fan D; Tsan R; Bucana C D; Wilmanns C; Fidler I J
Organ-specific modulation of steady-state mdr gene expression and drug resistance in murine colon cancer cells.
Journal of the National Cancer Institute 1994;86(12):913-20.
1994: Killion J J; Fidler I J
Systemic targeting of liposome-encapsulated immunomodulators to macrophages for treatment of cancer metastasis.
ImmunoMethods 1994;4(3):273-9.
1994: Xie B; Bucana C D; Fidler I J
Density-dependent induction of 92-kd type IV collagenase activity in cultures of A431 human epidermoid carcinoma cells.
The American journal of pathology 1994;144(5):1058-67.
1994: Xie B; Dong Z; Fidler I J
Regulatory mechanisms for the expression of type IV collagenases/gelatinases in murine macrophages.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(7):3637-44.
1994: Gohji K; Nakajima M; Fabra A; Bucana C D; von Eschenbach A C; Tsuruo T; Fidler I J
Regulation of gelatinase production in metastatic renal cell carcinoma by organ-specific fibroblasts.
Japanese journal of cancer research : Gann 1994;85(2):152-60.
1994: Dong Z; Staroselsky A H; Qi X; Xie K; Fidler I J
Inverse correlation between expression of inducible nitric oxide synthase activity and production of metastasis in K-1735 murine melanoma cells.
Cancer research 1994;54(3):789-93.
1994: Fan D; Poste G; Seid C; Earnest L E; Bull T; Clyne R K; Fidler I J
Reversal of multidrug resistance in murine fibrosarcoma cells by thioxanthene flupentixol.
Investigational new drugs 1994;12(3):185-95.
1994: Killion J J; Brown D R; Wilson M R; Lloyd M M; Fidler I J
Prevention of chemotherapy- or X-irradiation-induced monocytopenia by oral administration of lipophilic muramyl tripeptide.
Oncology research 1994;6(8):357-64.
1994: Gutman M; Singh R K; Price J E; Fan D; Fidler I J
Accelerated growth of human colon cancer cells in nude mice undergoing liver regeneration.
Invasion & metastasis 1994;14(1-6):362-71.
1994: Gutman M; Singh R K; Yoon S; Xie K; Bucana C D; Fidler I J
Leukocyte-induced angiogenesis and subcutaneous growth of B16 melanoma.
Cancer biotherapy 1994;9(2):163-70.
1993: Singh R K; Fidler I J
Synergism between human recombinant monocyte chemotactic and activating factor and lipopolysaccharide for activation of antitumor properties in human blood monocytes.
Lymphokine and cytokine research 1993;12(5):285-91.
1993: Singh R K; Berry K; Matsushima K; Yasumoto K; Fidler I J
Synergism between human monocyte chemotactic and activating factor and bacterial products for activation of tumoricidal properties in murine macrophages.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(5):2786-93.
1993: Dong Z; Qi X; Xie K; Fidler I J
Protein tyrosine kinase inhibitors decrease induction of nitric oxide synthase activity in lipopolysaccharide-responsive and lipopolysaccharide-nonresponsive murine macrophages.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(5):2717-24.
1993: Killion J J; Radinsky R; Dong Z; Fishbeck R; Whitworth P; Fidler I J
The immunogenic properties of drug-resistant murine tumor cells do not correlate with expression of the MDR phenotype.
Cancer immunology, immunotherapy : CII 1993;36(6):381-6.
1993: Dong Z; Qi X; Fidler I J
Tyrosine phosphorylation of mitogen-activated protein kinases is necessary for activation of murine macrophages by natural and synthetic bacterial products.
The Journal of experimental medicine 1993;177(4):1071-7.
1993: Radinsky R; Bucana C D; Ellis L M; Sanchez R; Cleary K R; Brigati D J; Fidler I J
A rapid colorimetric in situ messenger RNA hybridization technique for analysis of epidermal growth factor receptor in paraffin-embedded surgical specimens of human colon carcinomas.
Cancer research 1993;53(5):937-43.
1993: Luca M; Hunt B; Bucana C D; Johnson J P; Fidler I J; Bar-Eli M
Direct correlation between MUC18 expression and metastatic potential of human melanoma cells.
Melanoma research 1993;3(1):35-41.
1993: Dong Z; O'Brian C A; Fidler I J
Activation of tumoricidal properties in macrophages by lipopolysaccharide requires protein-tyrosine kinase activity.
Journal of leukocyte biology 1993;53(1):53-60.
1993: Risin S; Fujimaki T; Mestriner C A; Brown N M; Hopwood V L; Fidler I J; Pathak S
Clonal expansion of cells with trisomy of chromosomes 12 and X in an EBV-transformed lymphoblastoid cell line and establishment of a tumorigenic monoclonal cell line (48,XX,+X,+12).
Cytogenetics and cell genetics 1993;62(1):54-5.
1992: Fabra A; Nakajima M; Bucana C D; Fidler I J
Modulation of the invasive phenotype of human colon carcinoma cells by organ specific fibroblasts of nude mice.
Differentiation; research in biological diversity 1992;52(1):101-10.
1992: Bucana C D; Fabra A; Sanchez R; Fidler I J
Different patterns of macrophage infiltration into allogeneic-murine and xenogeneic-human neoplasms growing in nude mice.
The American journal of pathology 1992;141(5):1225-36.
1992: Zhang R D; Price J E; Fujimaki T; Bucana C D; Fidler I J
Differential permeability of the blood-brain barrier in experimental brain metastases produced by human neoplasms implanted into nude mice.
The American journal of pathology 1992;141(5):1115-24.
1992: Ullrich S E; Fidler I J
Liposomes containing muramyl tripeptide phosphatidylethanolamine (MTP-PE) are excellent adjuvants for induction of an immune response to protein and tumor antigens.
Journal of leukocyte biology 1992;52(5):489-94.
1992: Radinsky R; Weisberg H Z; Staroselsky A N; Fidler I J
Expression level of the nm23 gene in clonal populations of metastatic murine and human neoplasms.
Cancer research 1992;52(20):5808-14.
1992: Wilmanns C; Fan D; O'Brian C A; Bucana C D; Fidler I J
Orthotopic and ectopic organ environments differentially influence the sensitivity of murine colon carcinoma cells to doxorubicin and 5-fluorouracil.
International journal of cancer. Journal international du cancer 1992;52(1):98-104.
1992: Radinsky R; Fidler I J
Regulation of tumor cell growth at organ-specific metastases.
In vivo (Athens, Greece) 1992;6(4):325-31.
1992: Stephenson R A; Dinney C P; Gohji K; Ordóñez N G; Killion J J; Fidler I J
Metastatic model for human prostate cancer using orthotopic implantation in nude mice.
Journal of the National Cancer Institute 1992;84(12):951-7.
1992: Fan D; Fidler I J; Ward N E; Seid C; Earnest L E; Housey G M; O'Brian C A
Stable expression of a cDNA encoding rat brain protein kinase C-beta I confers a multidrug-resistant phenotype on rat fibroblasts.
Anticancer research 1992;12(3):661-7.
1992: Staroselsky A N; Radinsky R; Fidler I J; Pathak S; Chernajovsky Y; Frost P
The use of molecular genetic markers to demonstrate the effect of organ environment on clonal dominance in a human renal-cell carcinoma grown in nude mice.
International journal of cancer. Journal international du cancer 1992;51(1):130-8.
1992: Dinney C P; Utsugi T; Fidler I J; von Eschenbach A C; Killion J J
Immunotherapy of murine renal adenocarcinoma by systemic administration of liposomes containing the synthetic macrophage activator CGP 31362 or CGP 19835A in combination with interleukin 2 or gamma-interferon.
Cancer research 1992;52(5):1155-61.
1992: Kleinerman E S; Raymond A K; Bucana C D; Jaffe N; Harris M B; Krakoff I H; Benjamin R; Fidler I J
Unique histological changes in lung metastases of osteosarcoma patients following therapy with liposomal muramyl tripeptide (CGP 19835A lipid).
Cancer immunology, immunotherapy : CII 1992;34(4):211-20.
1992: Killion J J; Kleinerman E S; Wilson M R; Tanaka M; Fidler I J
Sequential therapy with chemotherapeutic drugs and liposome-encapsulated muramyl tripeptide: determination of potential interactions between these agents.
Oncology research 1992;4(10):413-8.
1992: Utsugi T; Brown D; Nii A; Fidler I J
Frozen-thawed human blood monocytes respond reproducibly to activation stimuli: implications for screening of BRMs.
Biotherapy (Dordrecht, Netherlands) 1992;5(4):301-8.
1991: Staroselsky A H; Pathak S; Chernajovsky Y; Tucker S L; Fidler I J
Predominance of the metastatic phenotype in somatic cell hybrids of the K-1735 murine melanoma.
Cancer research 1991;51(23 Pt 1):6292-8.
1991: Utsugi T; Dinney C P; Killion J J; Brown D; Fidler I J
In situ activation of mouse lung macrophages by coadministration of liposomes containing the lipopeptide CGP 31362 and interleukin 2 involves interaction with T lymphocytes and natural killer cells.
Lymphokine and cytokine research 1991;10(6):487-93.
1991: Fidler I J
Orthotopic implantation of human colon carcinomas into nude mice provides a valuable model for the biology and therapy of metastasis.
Cancer metastasis reviews 1991;10(3):229-43.
1991: Fidler I J
New developments in in vivo models of neoplasia.
Cancer metastasis reviews 1991;10(3):191-2.
1991: Pathak S; Staroselsky A N; Fidler I J
Specific chromosomal defects associated with metastatic potential in K-1735 melanoma clones. Involvement of chromosomes 4 and 14.
Cancer genetics and cytogenetics 1991;56(2):209-21.
1991: Esumi N; Fan D; Fidler I J
Inhibition of murine melanoma experimental metastasis by recombinant desulfatohirudin, a highly specific thrombin inhibitor.
Cancer research 1991;51(17):4549-56.
1991: Nii A; Utsugi T; Fan D; Denkins Y; Pak C; Brown D; van Hoogevest P; Fidler I J
Optimization of the liposomes encapsulating a new lipopeptide CGP 31362 for efficient activation of tumoricidal properties in monocytes and macrophages.
Journal of immunotherapy : official journal of the Society for Biological Therapy 1991;10(4):236-46.
1991: Dinney C P; Bucana C D; Utsugi T; Fidler I J; von Eschenbach A C; Killion J J
Therapy of spontaneous lung metastasis of murine renal adenocarcinoma by systemic administration of liposomes containing the macrophage activator CGP 31362.
Cancer research 1991;51(14):3741-7.
1991: Utsugi T; Schroit A J; Connor J; Bucana C D; Fidler I J
Elevated expression of phosphatidylserine in the outer membrane leaflet of human tumor cells and recognition by activated human blood monocytes.
Cancer research 1991;51(11):3062-6.
1991: Pak C C; Fidler I J
Molecular mechanisms for activated macrophage recognition of tumor cells.
Seminars in cancer biology 1991;2(3):189-95.
1991: Li L M; Kilbourn R G; Adams J; Fidler I J
Role of nitric oxide in lysis of tumor cells by cytokine-activated endothelial cells.
Cancer research 1991;51(10):2531-5.
1991: Zhang R D; Price J E; Schackert G; Itoh K; Fidler I J
Malignant potential of cells isolated from lymph node or brain metastases of melanoma patients and implications for prognosis.
Cancer research 1991;51(8):2029-35.
1991: Utsugi T; Fidler I J
Prostaglandin E2 does not inhibit tumoricidal activity of mouse macrophages against adherent tumor cells.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(6):2066-71.
1991: O'Brian C A; Fan D; Ward N E; Dong Z; Iwamoto L; Gupta K P; Earnest L E; Fidler I J
Transient enhancement of multidrug resistance by the bile acid deoxycholate in murine fibrosarcoma cells in vitro.
Biochemical pharmacology 1991;41(5):797-806.
1991: Nii A; Fan D; Fidler I J
Cytotoxic potential of liposomes containing tumor necrosis factor-alpha against sensitive and resistant target cells.
Journal of immunotherapy : official journal of the Society for Biological Therapy 1991;10(1):13-9.
1991: Fidler I J; Li L M; Ananthaswamy H N; Esumi N; Radinsky R; Price J E
Correlation of growth capacity of cells in hard agarose with successful transfection by the activated c-Ha-ras oncogene and in vivo proliferative capacity at metastatic sites.
Anticancer research 1991;11(1):17-24.
1991: Li L M; Nicolson G L; Fidler I J
Direct in vitro lysis of metastatic tumor cells by cytokine-activated murine vascular endothelial cells.
Cancer research 1991;51(1):245-54.
1991: Pak C C; Fidler I J
Liposomal delivery of biological response modifiers to macrophages.
Biotherapy (Dordrecht, Netherlands) 1991;3(1):55-64.
1991: Utsugi T; Dinney C P; Killion J J; Fidler I J
In situ activation of mouse macrophages and therapy of spontaneous renal cell cancer metastasis by liposomes containing the lipopeptide CGP 31362.
Cancer immunology, immunotherapy : CII 1991;33(6):375-81.
1991: Utsugi T; Nii A; Fan D; Pak C C; Denkins Y; van Hoogevest P; Fidler I J
Comparative efficacy of liposomes containing synthetic bacterial cell wall analogues for tumoricidal activation of monocytes and macrophages.
Cancer immunology, immunotherapy : CII 1991;33(5):285-92.
1991: Seid C A; Fidler I J; Clyne R K; Earnest L E; Fan D
Overcoming murine tumor cell resistance to vinblastine by presentation of the drug in multilamellar liposomes consisting of phosphatidylcholine and phosphatidylserine.
Selective cancer therapeutics 1991;7(3):103-12.
1991: Zhang R D; Fidler I J; Price J E
Relative malignant potential of human breast carcinoma cell lines established from pleural effusions and a brain metastasis.
Invasion & metastasis 1991;11(4):204-15.
1991: Fidler I J
7th Jan Waldenström Lecture. The biology of human cancer metastasis.
Acta oncologica (Stockholm, Sweden) 1991;30(6):668-75.
1990: Staroselsky A N; Fan D; O'Brian C A; Bucana C D; Gupta K P; Fidler I J
Site-dependent differences in response of the UV-2237 murine fibrosarcoma to systemic therapy with adriamycin.
Cancer research 1990;50(24):7775-80.
1990: Nakajima M; Morikawa K; Fabra A; Bucana C D; Fidler I J
Influence of organ environment on extracellular matrix degradative activity and metastasis of human colon carcinoma cells.
Journal of the National Cancer Institute 1990;82(24):1890-8.
1990: Fidler I J
Critical factors in the biology of human cancer metastasis: twenty-eighth G.H.A. Clowes memorial award lecture.
Cancer research 1990;50(19):6130-8.
1990: Fidler I J; Naito S; Pathak S
Orthotopic implantation is essential for the selection, growth and metastasis of human renal cell cancer in nude mice [corrected]
Cancer metastasis reviews 1990;9(2):149-65.
1990: Shin D M; Fidler I J; Bucana C D; Fan D; Hong W K; Killion J J
Superior antiproliferative effects mediated by interferon-alpha entrapped in liposomes against a newly established human lung cancer cell line.
Journal of biological response modifiers 1990;9(4):355-60.
1990: Frangos D N; Killion J J; Fan D; Fishbeck R; von Eschenbach A C; Fidler I J
The development of liposomes containing interferon alpha for the intravesical therapy of human superficial bladder cancer.
The Journal of urology 1990;143(6):1252-6.
1990: Fan D; Bucana C D; O'Brian C A; Zwelling L A; Seid C; Fidler I J
Enhancement of murine tumor cell sensitivity to adriamycin by presentation of the drug in phosphatidylcholine-phosphatidylserine liposomes.
Cancer research 1990;50(12):3619-26.
1990: Wang C Q; Kripke M L; Fidler I J
Ultraviolet-B-irradiated mouse epidermis releases mediators that stimulate melanoma cells.
Photodermatology, photoimmunology & photomedicine 1990;7(3):128-35.
1990: Staroselsky A; Pathak S; Fidler I J
Changes in clonal composition during in vivo growth of mixed subpopulations derived from the murine K-1735 melanoma.
Anticancer research 1990;10(2A):291-6.
1990: Whitworth P W; Pak C C; Esgro J; Kleinerman E S; Fidler I J
Macrophages and cancer.
Cancer metastasis reviews 1990;8(4):319-51.
1990: Schackert G; Price J E; Zhang R D; Bucana C D; Itoh K; Fidler I J
Regional growth of different human melanomas as metastases in the brain of nude mice.
The American journal of pathology 1990;136(1):95-102.
1990: Schackert H K; Fan D; Fidler I J
Transient inhibition of liver regeneration in mice by transforming growth factor-beta 1 encapsulated in liposomes.
Cancer communications 1990;2(5):165-71.
1990: Nii A; Fidler I J
The incubation of human blood monocytes with tumor necrosis factor-alpha leads to lysis of tumor necrosis factor-sensitive but not resistant tumor cells.
Lymphokine research 1990;9(2):113-24.
1990: Li L M; Shin D M; Fidler I J
Intrabronchial implantation of the Lewis lung tumor cell does not favor tumorigenicity and metastasis.
Invasion & metastasis 1990;10(3):129-41.
1990: Fidler I J; Nii A; Utsugi T; Brown D; Bakouche O; Kleinerman E S
Differential release of TNF-alpha, IL 1, and PGE2 by human blood monocytes subsequent to interaction with different bacterial derived agents.
Lymphokine research 1990;9(4):449-63.
1989: Jessup J M; Giavazzi R; Campbell D; Cleary K R; Morikawa K; Hostetter R; Atkinson E N; Fidler I J
Metastatic potential of human colorectal carcinomas implanted into nude mice: prediction of clinical outcome in patients operated upon for cure.
Cancer research 1989;49(24 Pt 1):6906-10.
1989: Li L; Price J E; Fan D; Zhang R D; Bucana C D; Fidler I J
Correlation of growth capacity of human tumor cells in hard agarose with their in vivo proliferative capacity at specific metastatic sites.
Journal of the National Cancer Institute 1989;81(18):1406-12.
1989: Killion J J; Fan D; Bucana C D; Frangos D N; Price J E; Fidler I J
Augmentation of antiproliferative activity of interferon alfa against human bladder tumor cell lines by encapsulation of interferon alfa within liposomes.
Journal of the National Cancer Institute 1989;81(18):1387-92.
1989: Kleinerman E S; Murray J L; Snyder J S; Cunningham J E; Fidler I J
Activation of tumoricidal properties in monocytes from cancer patients following intravenous administration of liposomes containing muramyl tripeptide phosphatidylethanolamine.
Cancer research 1989;49(16):4665-70.
1989: Price J E; Aukerman S L; Ananthaswamy H N; McIntyre B W; Schackert G; Schackert H K; Fidler I J
Metastatic potential of cloned murine melanoma cells transfected with activated c-Ha-ras.
Cancer research 1989;49(15):4274-81.
1989: Pak C C; Fidler I J
Activated macrophages distinguish undifferentiated-tumorigenic from differentiated-nontumorigenic murine erythroleukemia cells.
Differentiation; research in biological diversity 1989;41(1):49-55.
1989: Schackert H K; Fidler I J
Development of an animal model to study the biology of recurrent colorectal cancer originating from mesenteric lymph system metastases.
International journal of cancer. Journal international du cancer 1989;44(1):177-81.
1989: Connor J; Bucana C; Fidler I J; Schroit A J
Differentiation-dependent expression of phosphatidylserine in mammalian plasma membranes: quantitative assessment of outer-leaflet lipid by prothrombinase complex formation.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(9):3184-8.
1989: McCready D R; Balch C M; Fidler I J; Murray J L
Lack of comparability between binding of monoclonal antibodies to melanoma cells in vitro and localization in vivo.
Journal of the National Cancer Institute 1989;81(9):682-7.
1989: Killion J J; Fidler I J
The biology of tumor metastasis.
Seminars in oncology 1989;16(2):106-15.
1989: Morikawa K; Fidler I J
Heterogeneous response of human colon cancer cells to the cytostatic and cytotoxic effects of recombinant human cytokines: interferon-alpha, interferon-gamma, tumor necrosis factor, and interleukin-1.
Journal of biological response modifiers 1989;8(2):206-18.
1989: O'Brian C A; Fan D; Ward N E; Seid C; Fidler I J
Level of protein kinase C activity correlates directly with resistance to adriamycin in murine fibrosarcoma cells.
FEBS letters 1989;246(1-2):78-82.
1989: Morikawa K; Fan D; Denkins Y M; Levin B; Gutterman J U; Walker S M; Fidler I J
Mechanisms of combined effects of gamma-interferon and 5-fluorouracil on human colon cancers implanted into nude mice.
Cancer research 1989;49(4):799-805.
1989: Fidler I J; Nii A; Tsao J Y; Davis S; Kleinerman E S
Activated human blood monocytes trigger the antitumor activity of blood polymorphonuclear cells.
Lymphokine research 1989;8(4):427-37.
1989: Fidler I J; Ichinose Y
Mechanisms of macrophage-mediated tumor cell lysis: role for the monokines tumor necrosis factor and interleukin 1.
Progress in clinical and biological research 1989;288():169-81.
1989: Schackert G; Fan D; Nayar R; Fidler I J
Arrest and retention of multilamellar liposomes in the brain of normal mice or mice bearing experimental brain metastases.
Selective cancer therapeutics 1989;5(2):73-9.
1989: Fan D; Price J; Schackert H; Seid C; Wilmanns C; Chakrabarty S; Fidler I J
Antiproliferative activity of liposome-encapsulated transforming growth factor-beta against MDA-MB-435 human breast carcinoma cells.
Cancer communications 1989;1(6):337-43.
1989: Hume D A; Donahue R E; Fidler I J
The therapeutic effect of human recombinant macrophage colony stimulating factor (CSF-1) in experimental murine metastatic melanoma.
Lymphokine research 1989;8(1):69-77.
1989: Johnson J W; Nayar R; Killion J J; von Eschenbach A C; Fidler I J
Binding of liposomes to human bladder tumor epithelial cell lines: implications for an intravesical drug delivery system for the treatment of bladder cancer.
Selective cancer therapeutics 1989;5(4):147-55.
1989: Fan D; Chakrabarty S; Seid C; Bell C W; Schackert H; Morikawa K; Fidler I J
Clonal stimulation or inhibition of human colon carcinomas and human renal carcinomas mediated by transforming growth factor-beta 1.
Cancer communications 1989;1(2):117-25.
1989: Fidler I J; Fan D; Ichinose Y
Potent in situ activation of murine lung macrophages and therapy of melanoma metastases by systemic administration of liposomes containing muramyltripeptide phosphatidylethanolamine and interferon gamma.
Invasion & metastasis 1989;9(2):75-88.
1988: Morikawa K; Walker S M; Nakajima M; Pathak S; Jessup J M; Fidler I J
Influence of organ environment on the growth, selection, and metastasis of human colon carcinoma cells in nude mice.
Cancer research 1988;48(23):6863-71.
1988: Hume D A; Pavli P; Donahue R E; Fidler I J
The effect of human recombinant macrophage colony-stimulating factor (CSF-1) on the murine mononuclear phagocyte system in vivo.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(10):3405-9.
1988: Schackert G; Simmons R D; Buzbee T M; Hume D A; Fidler I J
Macrophage infiltration into experimental brain metastases: occurrence through an intact blood-brain barrier.
Journal of the National Cancer Institute 1988;80(13):1027-34.
1988: Price J E; Sauder D N; Fidler I J
Tumorigenicity and metastatic behavior in nude mice of two human squamous cell carcinoma lines that differ in production of the cytokine ETAF/IL-1.
The Journal of investigative dermatology 1988;91(3):258-62.
1988: Fidler I J
The biology of melanoma metastasis.
The Journal of dermatologic surgery and oncology 1988;14(8):875-81.
1988: Romerdahl C A; Donawho C; Fidler I J; Kripke M L
Effect of ultraviolet-B radiation on the in vivo growth of murine melanoma cells.
Cancer research 1988;48(14):4007-10.
1988: Ichinose Y; Bakouche O; Tsao J Y; Fidler I J
Tumor necrosis factor and IL-1 associated with plasma membranes of activated human monocytes lyse monokine-sensitive but not monokine-resistant tumor cells whereas viable activated monocytes lyse both.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(2):512-8.
1988: Schackert G; Fidler I J
Site-specific metastasis of mouse melanomas and a fibrosarcoma in the brain or meninges of syngeneic animals.
Cancer research 1988;48(12):3478-84.
1988: Schackert G; Fidler I J
Development of in vivo models for studies of brain metastasis.
International journal of cancer. Journal international du cancer 1988;41(4):589-94.
1988: Morikawa K; Walker S M; Jessup J M; Fidler I J
In vivo selection of highly metastatic cells from surgical specimens of different primary human colon carcinomas implanted into nude mice.
Cancer research 1988;48(7):1943-8.
1988: Price J E; Tarin D; Fidler I J
Influence of organ microenvironment on pigmentation of a metastatic murine melanoma.
Cancer research 1988;48(8):2258-64.
1988: Bakouche O; Ichinose Y; Heicappell R; Fidler I J; Lachman L B
Plasma membrane-associated tumor necrosis factor. A non-integral membrane protein possibly bound to its own receptor.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(4):1142-7.
1988: Price J E; Naito S; Fidler I J
Growth in an organ microenvironment as a selective process in metastasis.
Clinical & experimental metastasis 1988;6(1):91-102.
1988: Morikawa K; Nayar R; Fidler I J
In vitro activation of tumoricidal properties in mouse macrophages using the chemotactic peptide N-formyl-methionyl-leucyl-phenylalanine (FMLP) incorporated in liposomes.
Cancer immunology, immunotherapy : CII 1988;27(1):1-6.
1988: Ichinose Y; Tsao J Y; Fidler I J
Destruction of tumor cells by monokines released from activated human blood monocytes: evidence for parallel and additive effects of IL-1 and TNF.
Cancer immunology, immunotherapy : CII 1988;27(1):7-12.
1987: Nayar R; Morikawa K; Fidler I J
Characterization of liposomes containing the chemotactic peptide N-formyl-methionyl-leucyl-phenylalanine (FMLP) and their interaction with mouse macrophages.
Cancer drug delivery 1987;4(4):233-44.
1987: Aukerman S L; Fidler I J
Antigenicity of UV radiation-induced murine tumors correlates positively with the level of adenosine deaminase activity.
Cancer immunology, immunotherapy : CII 1987;25(3):175-9.
1986: Price J E; Aukerman S L; Fidler I J
Evidence that the process of murine melanoma metastasis is sequential and selective and contains stochastic elements.
Cancer research 1986;46(10):5172-8.
1986: Aukerman S L; Price J E; Fidler I J
Different deficiencies in the prevention of tumorigenic-low-metastatic murine K-1735b melanoma cells from producing metastases.
Journal of the National Cancer Institute 1986;77(4):915-24.

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