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Helmut Fiebig

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Martin Wald; Domen Zafred; Gerald Reese; Oliver Cromwell; Helmut Fiebig; Helga Kahlert; Walter Keller; Nina Krontal; Andreas Nandy
Hypoallergenic mutants of the Timothy grass pollen allergen Phl p 5 generated by proline mutations.
Oliver Cromwell; Paolo M Matricardi; Helmut Fiebig
Patient-tailored recombinant allergen products--mission impossible?
Helmut Fiebig; Helga Kahlert; Bernhard Weber; Roland Suck; Andreas Nandy; Oliver Cromwell
Antibody-based methods for standardization of allergoids and recombinant hypoallergens.

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2012: Martin Wald; Domen Zafred; Gerald Reese; Oliver Cromwell; Helmut Fiebig; Helga Kahlert; Walter Keller; Nina Krontal; Andreas Nandy
Hypoallergenic mutants of the Timothy grass pollen allergen Phl p 5 generated by proline mutations.
International archives of allergy and immunology 2012;159(2):130-42.
2009: Oliver Cromwell; Paolo M Matricardi; Helmut Fiebig
Patient-tailored recombinant allergen products--mission impossible?
Arbeiten aus dem Paul-Ehrlich-Institut (Bundesinstitut für Impfstoffe und biomedizinische Arzneimittel) Langen/Hessen 2009;96():210-7; discussion 217-8.
2009: Helmut Fiebig; Helga Kahlert; Bernhard Weber; Roland Suck; Andreas Nandy; Oliver Cromwell
Antibody-based methods for standardization of allergoids and recombinant hypoallergens.
Arbeiten aus dem Paul-Ehrlich-Institut (Bundesinstitut für Impfstoffe und biomedizinische Arzneimittel) Langen/Hessen 2009;96():71-82; discussion 82-3.
2008: Kerstin Westritschnig; Friedrich Horak; Ines Swoboda; Nadja Balic; Susanne Spitzauer; Michael Kundi; Helmut Fiebig; Roland Suck; Oliver Cromwell; Rudolf Valenta
Different allergenic activity of grass pollen allergens revealed by skin testing.
European journal of clinical investigation 2008;38(4):260-7.
2008: Helga Kahlert; Roland Suck; Bernhard Weber; Andreas Nandy; Martin Wald; Walter Keller; Oliver Cromwell; Helmut Fiebig
Characterization of a hypoallergenic recombinant Bet v 1 variant as a candidate for allergen-specific immunotherapy.
International archives of allergy and immunology 2008;145(3):193-206.
2007: Martin Wald; Helga Kahlert; Bernhard Weber; M Jankovic; Walter Keller; Oliver Cromwell; Andreas Nandy; Helmut Fiebig
Generation of a low immunoglobulin E-binding mutant of the timothy grass pollen major allergen Phl p 5a.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2007;37(3):441-50.
2006: Roland Suck; Timo Kamionka; Brigitte Schäffer; Rüdiger Wahl; Andreas Nandy; Bernhard Weber; Arnd Petersen; Ruth Birner-Gruenberger; Siva Charan D V; Walter Keller; Helmut Fiebig; Oliver Cromwell
Bacterially expressed and optimized recombinant Phl p 1 is immunobiochemically equivalent to natural Phl p 1.
Biochimica et biophysica acta 2006;1764(11):1701-9.
2006: Stefanie Kischnick; Bernhard Weber; Petra Verdino; Walter Keller; Ernst A Sanders; F Birger Anspach; Helmut Fiebig; Oliver Cromwell; Roland Suck
Bacterial fermentation of recombinant major wasp allergen Antigen 5 using oxygen limiting growth conditions improves yield and quality of inclusion bodies.
Protein expression and purification 2006;47(2):621-8.
2006: Oliver Cromwell; Helmut Fiebig; Roland Suck; Helga Kahlert; Andreas Nandy; Jens Kettner; Annemie Narkus
Strategies for recombinant allergen vaccines and fruitful results from first clinical studies.
Immunology and allergy clinics of North America 2006;26(2):261-81, vii.
2006: Helmut Fiebig; Helga Kahlert; Andreas Nandy; Martin Wald; Roland Suck; Bernhard Weber
Test procedures for allergoids and hypoallergenic recombinant allergens: immunological characterization.
Arbeiten aus dem Paul-Ehrlich-Institut (Bundesamt für Sera und Impfstoffe) zu Frankfurt a.M 2006;(95):135-46; discussion147-8, 155.
2006: Wolf-Meinhard Becker; Ronald van Ree; Helmut Fiebig; Oliver Cromwell; Bernhard Weber; Rafael Monsalve; DOMINGO BARBER; Monika Raulf-Heimsoth; Philippe Moingeon; Alain Didierlaurent; Gabriella Di Felice; Carlo Pini; Kay Fötisch; Stefan Vieths
Validation of quantitative, allergen-specific ELISAs.
Arbeiten aus dem Paul-Ehrlich-Institut (Bundesamt für Sera und Impfstoffe) zu Frankfurt a.M 2006;(95):91-7; discussion 97, 100-4.
2005: Andreas Nandy; Arnd Petersen; Martin Wald; Roland Suck; Helga Kahlert; Bernhard Weber; Wolf-Meinhard Becker; Oliver Cromwell; Helmut Fiebig
Primary structure, recombinant expression, and molecular characterization of Phl p 4, a major allergen of timothy grass (Phleum pratense).
Biochemical and biophysical research communications 2005;337(2):563-70.
2005: Marek Jutel; Lothar Jaeger; Roland Suck; Hanns Meyer; Helmut Fiebig; Oliver Cromwell
Allergen-specific immunotherapy with recombinant grass pollen allergens.
The Journal of allergy and clinical immunology 2005;116(3):608-13.
2005: Guro Gafvelin; Sarah Thunberg; Marianne Kronqvist; Hans Grönlund; Reidar Grönneberg; Marita Troye-Blomberg; Mübeccel Akdis; Helmut Fiebig; Ashok Purohit; Friedrich Horak; Jürgen Reisinger; Verena Niederberger; Cezmi A. Akdis; Oliver Cromwell; Gabrielle Pauli; Rudolf Valenta; Marianne van Hage
Cytokine and antibody responses in birch-pollen-allergic patients treated with genetically modified derivatives of the major birch pollen allergen Bet v 1.
International archives of allergy and immunology 2005;138(1):59-66.
2005: Tanja Ball; William Edstrom; Ludwig Mauch; Jacky Schmitt; Bernd Leistler; Helmut Fiebig; Wolfgang R Sperr; Alexander W Hauswirth; Peter Valent; Dietrich Kraft; Steven C Almo; Rudolf Valenta
Gain of structure and IgE epitopes by eukaryotic expression of the major Timothy grass pollen allergen, Phl p 1.
The FEBS journal 2005;272(1):217-27.
2004: Verena Niederberger; Friedrich Horak; Susanne Vrtala; Susanne Spitzauer; Maria-Theresa Krauth; Peter Valent; Jürgen Reisinger; Martina Pelzmann; Brigitte Hayek; Marianne Kronqvist; Guro Gafvelin; Hans Grönlund; Ashok Purohit; Roland Suck; Helmut Fiebig; Oliver Cromwell; Gabrielle Pauli; Marianne Van Hage-Hamsten; Rudolf Valenta
Vaccination with genetically engineered allergens prevents progression of allergic disease.
Proceedings of the National Academy of Sciences of the United States of America 2004;101 Suppl 2():14677-82.
2004: Mübeccel Akdis; Johan Verhagen; Alison Taylor; Fariba Karamloo; Christian Karagiannidis; Reto Crameri; Sarah Thunberg; Günnur Deniz; Rudolf Valenta; Helmut Fiebig; Christian Kegel; Rainer Disch; Carsten B Schmidt-Weber; Kurt Blaser; Cezmi A. Akdis
Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells.
The Journal of experimental medicine 2004;199(11):1567-75.
2004: Ines Swoboda; Monika Grote; Petra Verdino; Walter Keller; Mohan B Singh; Nicole de Weerd; Wolfgang R Sperr; Peter Valent; Nadja Balic; Rudolf Reichelt; Roland Suck; Helmut Fiebig; Rudolf Valenta; Susanne Spitzauer
Molecular characterization of polygalacturonases as grass pollen-specific marker allergens: expulsion from pollen via submicronic respirable particles.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(10):6490-500.
2004: Oliver Cromwell; Roland Suck; Helga Kahlert; Andreas Nandy; Bernhard Weber; Helmut Fiebig
Transition of recombinant allergens from bench to clinical application.
Methods (San Diego, Calif.) 2004;32(3):300-12.
2004: Roland Suck; Arnd Petersen; Bernhard Weber; Wolf-Meinhard Becker; Helmut Fiebig; Oliver Cromwell
Analytical and preparative native polyacrylamide gel electrophoresis: Investigation of the recombinant and natural major grass pollen allergen Phl p 2.
Electrophoresis 2004;25(1):14-9.
2004: Vera Mahler; Susanne Vrtala; Oliver Kuss; Thomas L Diepgen; Roland Suck; Oliver Cromwell; Helmut Fiebig; Arnulf Hartl; Josef Thalhamer; G Schuler; D Kraft; R Valenta
Vaccines for birch pollen allergy based on genetically engineered hypoallergenic derivatives of the major birch pollen allergen, Bet v 1.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2004;34(1):115-22.
2003: Helga Kahlert; Oliver Cromwell; Helmut Fiebig
Measurement of basophil-activating capacity of grass pollen allergens, allergoids and hypoallergenic recombinant derivatives by flow cytometry using anti-CD203c.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2003;33(9):1266-72.
2003: Roland Suck; Bernhard Weber; Brigitte Schäffer; Ellen Diedrich; Timo Kamionka; Helmut Fiebig; Oliver Cromwell
Purification strategy for recombinant Phl p 6 is applicable to the natural allergen and yields biochemically and immunologically comparable preparations.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2003;787(2):357-68.
2003: Ute Lepp; Frank Eberhardt; Gabriele Schramm; Peter Zabel; Roland Suck; Hans Meyer; Helmut Fiebig; Oliver Cromwell; Wolf-Meinhard Becker
Approaches based on mutated or modified recombinant grass pollen allergens--in vivo evaluation of the constructs.
Arbeiten aus dem Paul-Ehrlich-Institut (Bundesamt für Sera und Impfstoffe) zu Frankfurt a.M 2003;(94):188-91.
2003: Oliver Cromwell; Helga Kahlert; Gabriele Schramm; Roland Suck; Andreas Nandy; Bernhard Weber; Helmut Fiebig
Mechanisms of immunotherapy with allergoids: lessons for the development of recombinant allergens with reduced IgE-binding activity.
Arbeiten aus dem Paul-Ehrlich-Institut (Bundesamt für Sera und Impfstoffe) zu Frankfurt a.M 2003;(94):156-61; discussion 161-2.
2002: Roland Suck; Andreas Nandy; Bernhard Weber; M Stock; Helmut Fiebig; Oliver Cromwell
Rapid method for arrayed investigation of IgE-reactivity profiles using natural and recombinant allergens.
Allergy 2002;57(9):821-4.
2002: Ines Swoboda; Nicole de Weerd; Prem L Bhalla; Verena Niederberger; Wolfgang R Sperr; Peter Valent; Helga Kahlert; Helmut Fiebig; Petra Verdino; Walter Keller; Christof Ebner; Susanne Spitzauer; Rudolf Valenta; Mohan B Singh
Mutants of the major ryegrass pollen allergen, Lol p 5, with reduced IgE-binding capacity: candidates for grass pollen-specific immunotherapy.
European journal of immunology 2002;32(1):270-80.
2001: Arnd Petersen; Roland Suck; S Hagen; Oliver Cromwell; Helmut Fiebig; Wolf-Meinhard Becker
Group 13 grass allergens: structural variability between different grass species and analysis of proteolytic stability.
The Journal of allergy and clinical immunology 2001;107(5):856-62.
2000: Roland Suck; S Hagen; Oliver Cromwell; Helmut Fiebig
The high molecular mass allergen fraction of timothy grass pollen (Phleum pratense) between 50-60 kDa is comprised of two major allergens: Phl p 4 and Phl p 13.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2000;30(10):1395-402.
2000: Helga Kahlert; Evelin Grage-Griebenow; HT Stüwe; Oliver Cromwell; Helmut Fiebig
T cell reactivity with allergoids: influence of the type of APC.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(4):1807-15.
2000: Roland Suck; Bernhard Weber; Helga Kahlert; S Hagen; Oliver Cromwell; Helmut Fiebig
Purification and immunobiochemical characterization of folding variants of the recombinant major wasp allergen Ves v 5 (antigen 5).
International archives of allergy and immunology 2000;121(4):284-91.
2000: Roland Suck; Arnd Petersen; S Hagen; Oliver Cromwell; Wolf-Meinhard Becker; Helmut Fiebig
Complementary DNA cloning and expression of a newly recognized high molecular mass allergen phl p 13 from timothy grass pollen (Phleum pratense).
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2000;30(3):324-32.
1999: Roland Suck; S Hagen; Oliver Cromwell; Helmut Fiebig
Rapid and efficient purification of Phleum pratense major allergens Phl p 1 and group Phl p 2/3 using a two-step procedure.
Journal of immunological methods 1999;229(1-2):73-80.
1999: H Kahler; HT Stüwe; Oliver Cromwell; Helmut Fiebig
Reactivity of T cells with grass pollen allergen extract and allergoid.
International archives of allergy and immunology 1999;120(2):146-57.
1999: E Aden; B Weber; J Bossert; M Teppke; E Frank; Rüdiger Wahl; Helmut Fiebig; Oliver Cromwell
Standardization of Alternaria alternata: extraction and quantification of alt a 1 by using an mAb-based 2-site binding assay.
The Journal of allergy and clinical immunology 1999;104(1):128-35.
1999: Gabriele Schramm; Helga Kahlert; Roland Suck; B Weber; HT Stüwe; WD Müller; Albrecht Bufe; Wolf-Meinhard Becker; MW Schlaak; L Jäger; Oliver Cromwell; Helmut Fiebig
"Allergen engineering": variants of the timothy grass pollen allergen Phl p 5b with reduced IgE-binding capacity but conserved T cell reactivity.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(4):2406-14.
1999: Oliver Cromwell; Bernhard Weber; Helga Kahlert; Helmut Fiebig
Standardization in quality control of modified end-products.
Arbeiten aus dem Paul-Ehrlich-Institut (Bundesamt für Sera und Impfstoffe) zu Frankfurt a.M 1999;(93):93-9; discussion 100.
1999: Helmut Fiebig; Helga Kahlert
[Desensitization with allergens: early, specific, effective therapy of immune system almost without side effects. Interview by Dr. Barbara Scholtissek].
Wiener medizinische Wochenschrift (1946) 1999;149(14-15):447, 449-50.
1998: WD Müller; Theodor Karamfilov; Helga Kahlert; HT Stüwe; Bärbel Fahlbusch; Oliver Cromwell; Helmut Fiebig; L Jäger
Mapping of T-cell epitopes of Phl p 5: evidence for crossreacting and non-crossreacting T-cell epitopes within Phl p 5 isoallergens.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1998;28(12):1538-48.
1998: Bärbel Fahlbusch; WD Müller; Olga Rudeschko; L Jäger; Oliver Cromwell; Helmut Fiebig
Detection and quantification of group 4 allergens in grass pollen extracts using monoclonal antibodies.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1998;28(7):799-807.
1996: Helga Kahlert; B Weber; M Teppke; R Wahl; Oliver Cromwell; Helmut Fiebig
Characterization of major allergens of Parietaria officinalis.
International archives of allergy and immunology 1996;109(2):141-9.