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Walter Fiedler

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Leticia Oliveira-Ferrer; Jasmin Wellbrock; Carsten Bokemeyer; Melanie Braig; Suleyman Ergun; Walter Fiedler; Jessica Hauschild; Marianne Klokow; Gunter Schuch
The metabolite 3-hydroxiglutaric acid effectively reduces glioblastoma growth in vivo by affecting the structural integrity of tumor vasculature.
Alexander Schultze; Emre Yekebas; Klaus Pantel; Uta Reichelt; Sabine Riethdorf; Thomas Schmidt; Isabel Ben Batalla; Carsten Bokemeyer; Michael Bubenheim; Katharina E Effenberger; Andreas Erbersdobler; Walter Fiedler; Jakob R Izbicki; Sonja Loges
VEGFR-1 expression levels predict occurrence of disseminated tumor cells in the bone marrow of patients with esophageal carcinoma.
Anna Flammiger; Marion Schneider; Ulrike Bacher; Carsten Bokemeyer; Walter Fiedler; Mascha Binder
Critical imbalance of TNF-α and soluble TNF receptor 1 in a patient with macrophage activation syndrome: potential implications for diagnostics and treatment.

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2012: Leticia Oliveira-Ferrer; Jasmin Wellbrock; Carsten Bokemeyer; Melanie Braig; Suleyman Ergun; Walter Fiedler; Jessica Hauschild; Marianne Klokow; Gunter Schuch
The metabolite 3-hydroxiglutaric acid effectively reduces glioblastoma growth in vivo by affecting the structural integrity of tumor vasculature.
Cancer letters 2012;326(2):161-7.
2012: Alexander Schultze; Emre Yekebas; Klaus Pantel; Uta Reichelt; Sabine Riethdorf; Thomas Schmidt; Isabel Ben Batalla; Carsten Bokemeyer; Michael Bubenheim; Katharina E Effenberger; Andreas Erbersdobler; Walter Fiedler; Jakob R Izbicki; Sonja Loges
VEGFR-1 expression levels predict occurrence of disseminated tumor cells in the bone marrow of patients with esophageal carcinoma.
Clinical & experimental metastasis 2012;29(8):879-87.
2012: Anna Flammiger; Marion Schneider; Ulrike Bacher; Carsten Bokemeyer; Walter Fiedler; Mascha Binder
Critical imbalance of TNF-α and soluble TNF receptor 1 in a patient with macrophage activation syndrome: potential implications for diagnostics and treatment.
Acta haematologica 2012;128(2):69-72.
2011: J Wellbrock; Walter Fiedler
Clinical experience with antiangiogenic therapy in leukemia.
Current cancer drug targets 2011;11(9):1053-68.
2011: Alexander Schultze; Walter Fiedler
Clinical importance and potential use of small molecule inhibitors of focal adhesion kinase.
Anti-cancer agents in medicinal chemistry 2011;11(7):593-9.
2011: Christian Schaefer; Malte Schroeder; Lennart Viezens; Walter Fiedler; Ina Fuhrhop; Jasmin Otten; Wolfgang Rüther; Nils Hansen-Algenstaedt
Primary tumor dependent inhibition of tumor growth, angiogenesis, and perfusion of secondary breast cancer in bone.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2011;29(8):1251-8.
2011: Walter Fiedler; G Giaccone; P Lasch; I van der Horst; Nicoletta M Brega; R Courtney; A Abbattista; D R Shalinsky; Carsten Bokemeyer; E Boven
Phase I trial of SU14813 in patients with advanced solid malignancies.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2011;22(1):195-201.
2010: Alexander Schultze; Sebastian Decker; Jasmin Otten; Andrea Kristina Horst; Gabi Vohwinkel; Gunter Schuch; Carsten Bokemeyer; Sonja Loges; Walter Fiedler
TAE226-mediated inhibition of focal adhesion kinase interferes with tumor angiogenesis and vasculogenesis.
Investigational new drugs 2010;28(6):825-33.
2010: Christian Schaefer; Ina Fuhrhop; Malte Schroeder; Lennart Viezens; Jasmin Otten; Walter Fiedler; Wolfgang Rüther; Nils Hansen-Algenstaedt
Microcirculation of secondary bone tumors in vivo: the impact of minor surgery at a distal site.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2010;28(11):1515-21.
2010: Andreas H Marx; Eike C Burandt; Matthias Choschzick; Ronald Simon; Emre F Yekebas; Jussuf T Kaifi; Martina Mirlacher; Djordje Atanackovic; Carsten Bokemeyer; Walter Fiedler; Luigi Terracciano; Guido Sauter; Jakob R Izbicki
Heterogenous high-level HER-2 amplification in a small subset of colorectal cancers.
Human pathology 2010;41(11):1577-85.
2010: Andreas H Marx; Margarete Zielinski; Charlotte-Marie Kowitz; Ana-Maria Dancau; Sabrina Thieltges; Ronald Simon; Matthias Choschzick; Emre F Yekebas; Jussuf T Kaifi; Martina Mirlacher; Djordje Atanackovic; Tim H Brümmendorf; Walter Fiedler; Carsten Bokemeyer; Jakob R Izbicki; Guido Sauter
Homogeneous EGFR amplification defines a subset of aggressive Barrett's adenocarcinomas with poor prognosis.
Histopathology 2010;57(3):418-26.
2010: Alexander Schultze; Walter Fiedler
Therapeutic potential and limitations of new FAK inhibitors in the treatment of cancer.
Expert opinion on investigational drugs 2010;19(6):777-88.
2010: Walter Fiedler; Rolf M Mesters; Michael Heuser; Gerhard Ehninger; Wolfgang E Berdel; Ute Zirrgiebel; Jane D Robertson; Tom A Puchalski; Barbara Collins; Juliane M Jürgensmeier; Hubert Serve
An open-label, Phase I study of cediranib (RECENTIN) in patients with acute myeloid leukemia.
Leukemia research 2010;34(2):196-202.
2010: Jasmin Otten; Carsten Bokemeyer; Walter Fiedler
Tgf-Beta superfamily receptors-targets for antiangiogenic therapy?
Journal of oncology 2010;2010():317068.
2010: Sebastian Kobold; Nerbil Killic; Tim Lütkens; Carsten Bokemeyer; Walter Fiedler
Isolated limb perfusion with melphalan for the treatment of intractable primary cutaneous diffuse large B-cell lymphoma leg type.
Acta haematologica 2010;123(3):179-81.
2009: Sunday Ocheni; Gabriela B Iwanski; Philippe Schafhausen; Axel R Zander; Francis Ayuk; Evgeny Klyuchnikov; Tatjana Zabelina; Walter Fiedler; Susanne Schnittger; Andreas Hochhaus; Tim H Brümmendorf; Nicolaus Kröger; Ulrike Bacher
Characterisation of extramedullary relapse in patients with chronic myeloid leukemia in advanced disease after allogeneic stem cell transplantation.
Leukemia & lymphoma 2009;50(4):551-8.
2009: Sebastian Kobold; Hartmut Merz; Markus Tiemann; Carolina Mahuad; Carsten Bokemeyer; Irmtraut Koop; Walter Fiedler
Primary NK/T cell lymphoma nasal type of the stomach with skin involvement: a case report.
Rare tumors 2009;1(2):e58.
2008: Artur Gontarewicz; Stefan Balabanov; Gunhild Keller; Jens Panse; Philippe Schafhausen; Carsten Bokemeyer; Walter Fiedler; Jurgen Moll; Tim H Brümmendorf
PHA-680626 exhibits anti-proliferative and pro-apoptotic activity on Imatinib-resistant chronic myeloid leukemia cell lines and primary CD34+ cells by inhibition of both Bcr-Abl tyrosine kinase and Aurora kinases.
Leukemia research 2008;32(12):1857-65.
2008: Jasmin Otten; Alexander Schultze; Philippe Schafhausen; Svenja Otterstetter; Judith Dierlamm; Carsten Bokemeyer; Tim H Brummendorf; Walter Fiedler; Sonja Loges
Blood outgrowth endothelial cells from chronic myeloid leukaemia patients are BCR/ABL1 negative.
British journal of haematology 2008;142(1):115-8.
2008: Walter Fiedler; Gunter Schuch; Sonja Loges
Prognostic implication of expression of Angiopoietin-2 in acute myeloid leukemia.
Leukemia research 2008;32(6):843-4.
2008: Artur Gontarewicz; Stefan Balabanov; Gunhild Keller; Riccardo Colombo; Alessio Graziano; Enrico Pesenti; Daniel Benten; Carsten Bokemeyer; Walter Fiedler; Jurgen Moll; Tim H Brümmendorf
Simultaneous targeting of Aurora kinases and Bcr-Abl kinase by the small molecule inhibitor PHA-739358 is effective against imatinib-resistant BCR-ABL mutations including T315I.
Blood 2008;111(8):4355-64.
2008: Leticia Oliveira-Ferrer; Jessica Hauschild; Walter Fiedler; Carsten Bokemeyer; Johannes Nippgen; Ilhan Celik; Gunter Schuch
Cilengitide induces cellular detachment and apoptosis in endothelial and glioma cells mediated by inhibition of FAK/src/AKT pathway.
Journal of experimental & clinical cancer research : CR 2008;27():86.
2008: Christian Schaefer; M Krause; I Fuhrhop; M Schroeder; Petra Algenstaedt; Walter Fiedler; Wolfgang Rüther; Nils Hansen-Algenstaedt
Time-course-dependent microvascular alterations in a model of myeloid leukemia in vivo.
Leukemia 2008;22(1):59-65.
2007: Ursula M Gehling; Süleyman Ergün; Walter Fiedler
CFU-EC: how they were originally defined.
Blood 2007;110(3):1073.
2007: Sonja Loges; Martin Butzal; Jasmin Otten; Michaela Schweizer; Uta Fischer; Carsten Bokemeyer; Dieter K Hossfeld; Gunter Schuch; Walter Fiedler
Cilengitide inhibits proliferation and differentiation of human endothelial progenitor cells in vitro.
Biochemical and biophysical research communications 2007;357(4):1016-20.
2007: Sonja Loges; Henning Clausen; Uta Reichelt; Michael Bubenheim; Andreas Erbersdobler; Paulus G Schurr; Emre F Yekebas; Gunter Schuch; Jakob R Izbicki; Klaus Pantel; Carsten Bokemeyer; Walter Fiedler
Determination of microvessel density by quantitative real-time PCR in esophageal cancer: correlation with histologic methods, angiogenic growth factor expression, and lymph node metastasis.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(1):76-80.
2006: Sonja Loges; Heike Tinnefeld; Anja Metzner; Manfred Jücker; Martin Butzal; Melanie Bruweleit; Uta Fischer; Elena Draab; Gunter Schuch; Anne Marie O'-Farrel; Dieter K Hossfeld; Carsten Bokemeyer; Walter Fiedler
Downregulation of VEGF-A, STAT5 and AKT in acute myeloid leukemia blasts of patients treated with SU5416.
Leukemia & lymphoma 2006;47(12):2601-9.
2006: Kevin Dierck; Kazuya Machida; Anja Voigt; Julian Thimm; Martin Horstmann; Walter Fiedler; Bruce J Mayer; Peter Nollau
Quantitative multiplexed profiling of cellular signaling networks using phosphotyrosine-specific DNA-tagged SH2 domains.
Nature methods 2006;3(9):737-44.
2006: Falk Ehmann; Stefan Horn; Lizet Garcia-Palma; Wiebke Wegner; Walter Fiedler; Klaudia Giehl; Georg W Mayr; Manfred Jücker
Detection of N-RAS and K-RAS in their active GTP-bound form in acute myeloid leukemia without activating RAS mutations.
Leukemia & lymphoma 2006;47(7):1387-91.
2006: Walter Fiedler; N Tchen; J Bloch; Pierre Fargeot; Roberto Sorio; J B Vermorken; L Collette; D Lacombe; Chris Twelves
A study from the EORTC new drug development group: open label phase II study of sabarubicin (MEN-10755) in patients with progressive hormone refractory prostate cancer.
European journal of cancer (Oxford, England : 1990) 2006;42(2):200-4.
2005: Eckart Laack; Antje Scheffler; Iris Burkholder; Ina Boeters; Birte Andritzky; Gunter Schuch; Michael Görn; Gaby Vohwinkel; Lutz Edler; Walter Fiedler; Dieter K Hossfeld
Pretreatment vascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP-9) serum levels in patients with metastatic non-small cell lung cancer (NSCLC).
Lung cancer (Amsterdam, Netherlands) 2005;50(1):51-8.
2005: Gunter Schuch; Leticia Oliveira-Ferrer; Sonja Loges; Eckart Laack; Carsten Bokemeyer; Dieter K Hossfeld; Walter Fiedler; Suleyman Ergun
Antiangiogenic treatment with endostatin inhibits progression of AML in vivo.
Leukemia 2005;19(8):1312-7.
2005: Juergen Bruns; Walter Fiedler; Mathias Werner; Günter Delling
Dedifferentiated chondrosarcoma--a fatal disease.
Journal of cancer research and clinical oncology 2005;131(6):333-9.
2005: Gunter Schuch; Maike de Wit; Jan Höltje; Eckart Laack; Georgia Schilling; Dieter K Hossfeld; Walter Fiedler; Paul Scigalla; Mark S Jacobs
Case 2. Hemangioblastomas: diagnosis of von Hippel-Lindau disease and antiangiogenic treatment with SU5416.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(15):3624-6.
2005: Nils Hansen-Algenstaedt; Claudia Joscheck; Christian Schaefer; Katrin Lamszus; Lars Wolfram; Tanja Biermann; Petra Algenstaedt; Marc A Brockmann; Carsten Heintz; Walter Fiedler; Wolfgang Rüther
Long-term observation reveals time-course-dependent characteristics of tumour vascularisation.
European journal of cancer (Oxford, England : 1990) 2005;41(7):1073-85.
2005: Sonja Loges; Gerhard Heil; Melanie Bruweleit; Volker Schoder; Martin Butzal; Uta Fischer; Ursula M Gehling; Gunter Schuch; Dieter K Hossfeld; Walter Fiedler
Analysis of concerted expression of angiogenic growth factors in acute myeloid leukemia: expression of angiopoietin-2 represents an independent prognostic factor for overall survival.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(6):1109-17.
2005: Walter Fiedler; Hubert Serve; Hartmut Döhner; Michael Schwittay; Oliver G Ottmann; Anne-Marie O'Farrell; Carlo Bello; Randy Allred; William C Manning; Julie M Cherrington; Sharianne G Louie; Weiru Hong; Nicoletta M Brega; Giorgio Massimini; Paul Scigalla; Wolfgang E Berdel; Dieter K Hossfeld
A phase 1 study of SU11248 in the treatment of patients with refractory or resistant acute myeloid leukemia (AML) or not amenable to conventional therapy for the disease.
Blood 2005;105(3):986-93.
2004: Florian Langer; Ali Amirkhosravi; Sonja Loges; Todd Meyer; Barbara Eifrig; Dieter K Hossfeld; Walter Fiedler; John L Francis
An in vitro study on the mechanisms of coagulation activation in acute myelogenous leukemia (AML): role of tissue factor regulation by cytotoxic drugs and GM-CSF.
Thrombosis and haemostasis 2004;92(5):1136-46.
2004: Martin Butzal; Sonja Loges; Michaela Schweizer; Uta Fischer; Ursula M Gehling; Dieter K Hossfeld; Walter Fiedler
Rapamycin inhibits proliferation and differentiation of human endothelial progenitor cells in vitro.
Experimental cell research 2004;300(1):65-71.
2004: Sonja Loges; Boris Fehse; Marc A Brockmann; Katrin Lamszus; Martin Butzal; Markus Guckenbiehl; Gunter Schuch; Süleyman Ergün; Uta Fischer; Axel R Zander; Dieter K Hossfeld; Walter Fiedler; Ursula M Gehling
Identification of the adult human hemangioblast.
Stem cells and development 2004;13(3):229-42.
2003: Anne-Marie O'Farrell; James M Foran; Walter Fiedler; Hubert Serve; Ronald L Paquette; Maureen A Cooper; Helene A Yuen; Sharianne G Louie; Heidi Kim; Susan Nicholas; Michael C Heinrich; Wolfgang E Berdel; Carlo Bello; Mark Jacobs; Paul Scigalla; William C Manning; Stephen Kelsey; Julie M Cherrington
An innovative phase I clinical study demonstrates inhibition of FLT3 phosphorylation by SU11248 in acute myeloid leukemia patients.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(15):5465-76.
2003: Walter Fiedler; Rolf M Mesters; Heike Tinnefeld; Sonja Loges; Peter Staib; Ulrich Duhrsen; Michael Flasshove; Oliver G Ottmann; Wolfram Jung; Franco Cavalli; Rolf Kuse; Joerg Thomalla; Hubert Serve; Anne-Marie O'Farrell; Mark Jacobs; Nicoletta M Brega; Paul Scigalla; Dieter K Hossfeld; Wolfgang E Berdel
A phase 2 clinical study of SU5416 in patients with refractory acute myeloid leukemia.
Blood 2003;102(8):2763-7.
2002: Eckart Laack; A Köhler; Christian Kugler; Thorsten Dierlamm; Claudia Knuffmann; Gaby Vohwinkel; A Niestroy; N Dahlmann; Anja Peters; J Berger; Walter Fiedler; Dieter K Hossfeld
Pretreatment serum levels of matrix metalloproteinase-9 and vascular endothelial growth factor in non-small-cell lung cancer.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2002;13(10):1550-7.
2002: Eckart Laack; Thorsten Dierlamm; Claudia Knuffmann; Johann Popp; Birgit Schmied; Heinz Duerk; Georg Wacker-Backerhaus; Wolfgang Zeller; Karl Verpoort; Walter Fiedler; Dieter Kurt Hossfeld
Docetaxel and carboplatin as second-line chemotherapy for metastatic non-small cell lung cancer.
Lung cancer (Amsterdam, Netherlands) 2002;36(3):303-7.
2002: Manfred Jücker; K Südel; Stefan Horn; M Sickel; W Wegner; Walter Fiedler; Ricardo A Feldman
Expression of a mutated form of the p85alpha regulatory subunit of phosphatidylinositol 3-kinase in a Hodgkin's lymphoma-derived cell line (CO).
Leukemia 2002;16(5):894-901.
2002: Thorsten Dierlamm; Eckart Laack; Judith Dierlamm; Walter Fiedler; Dieter K Hossfeld
IgM myeloma: a report of four cases.
Annals of hematology 2002;81(3):136-9.
2001: Rolf M Mesters; Teresa Padró; Ralf Bieker; Martin B Steins; Michael Kreuter; M Göner; S Kelsey; Paul Scigalla; Walter Fiedler; Thomas Büchner; Wolfgang E Berdel
Stable remission after administration of the receptor tyrosine kinase inhibitor SU5416 in a patient with refractory acute myeloid leukemia.
Blood 2001;98(1):241-3.
2001: Walter Fiedler; W Krüger; Eckart Laack; T Mende; Gaby Vohwinkel; Dieter K Hossfeld
A clinical trial of edrecolomab, interleukin-2 and GM-CSF in patients with advanced colorectal cancer.
Oncology reports 2001;8(2):225-31.
2001: S Ergün; Nerbil Kilic; Jan-Henner Wurmbach; Alireza Ebrahimnejad; Malkanthi Fernando; Sema Sevinc; E Kilic; Fariba Chalajour; Walter Fiedler; Heidrun Lauke; K Lamszus; P Hammerer; Joachim Weil; Hermann Herbst; J Folkman
Endostatin inhibits angiogenesis by stabilization of newly formed endothelial tubes.
Angiogenesis 2001;4(3):193-206.
2001: Ulrich Dührsen; T Martinez; Gaby Vohwinkel; Süleyman Ergün; L Sun; G McMahon; Jan Dürig; Dieter K Hossfeld; Walter Fiedler
Effects of vascular endothelial and platelet-derived growth factor receptor inhibitors on long-term cultures from normal human bone marrow.
Growth factors (Chur, Switzerland) 2001;19(1):1-17.
2000: Nicolaus Kröger; Tatjana Zabelina; Stefan Sonnenberg; William H Krüger; Helmut Renges; Norbert Stute; F Finkenstein; U Mayer; K Holstein; Walter Fiedler; H Colberg; Ruth Sonnen; Rolf Kuse; Dietrich Braumann; Bernd Metzner; F del Valle; Rudolf Erttmann; Hartmut Kabisch; Axel R Zander
Dose-dependent effect of etoposide in combination with busulfan plus cyclophosphamide as conditioning for stem cell transplantation in patients with acute myeloid leukemia.
Bone marrow transplantation 2000;26(7):711-6.
2000: Ursula M Gehling; Süleyman Ergün; U Schumacher; Christoph Wagener; K Pantel; M Otte; Gunter Schuch; Philippe Schafhausen; T Mende; Nerbil Kilic; K Kluge; B Schäfer; Dieter K Hossfeld; Walter Fiedler
In vitro differentiation of endothelial cells from AC133-positive progenitor cells.
Blood 2000;95(10):3106-12.
2000: Walter Fiedler; R P Henke; S Ergün; U Schumacher; Ursula M Gehling; Gaby Vohwinkel; Nerbil Kilic; Dieter K Hossfeld
Derivation of a new hematopoietic cell line with endothelial features from a patient with transformed myeloproliferative syndrome: a case report.
Cancer 2000;88(2):344-51.
1999: Ullrich Graeven; Walter Fiedler; S Karpinski; Süleyman Ergün; Nerbil Kilic; Ulrich Rodeck; Wolff Schmiegel; Dieter K Hossfeld
Melanoma-associated expression of vascular endothelial growth factor and its receptors FLT-1 and KDR.
Journal of cancer research and clinical oncology 1999;125(11):621-9.
1999: Nerbil Kilic; Heidrun Lauke; Walter Fiedler; Tobias Pottek; E Kilic; M R Freeman; S Ergün
Angiogenic switch and vascular stability in human Leydig cell tumours.
Angiogenesis 1999;3(3):231-40.
1998: Süleyman Ergün; W Luttmer; Walter Fiedler; Adolf F Holstein
Functional expression and localization of vascular endothelial growth factor and its receptors in the human epididymis.
Biology of reproduction 1998;58(1):160-8.
1997: Axel R Zander; C Berger; Nicolaus Kröger; M Stockshläder; William H Krüger; Martin Horstmann; Jan Grimm; W Zeller; Hartmut Kabisch; Rudolf Erttmann; P Schönrock; Rolf Kuse; Dietrich Braumann; Hans-Jochen Illiger; Walter Fiedler; M de Witt; K D Hossfeld; HJ Weh
High dose chemotherapy with busulfan, cyclophosphamide, and etoposide as conditioning regimen for allogeneic bone marrow transplantation for patients with acute myeloid leukemia in first complete remission.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(12 Pt 2):2671-5.
1997: Süleyman Ergün; N Kiliç; Walter Fiedler; Amal K Mukhopadhyay
Vascular endothelial growth factor and its receptors in normal human testicular tissue.
Molecular and cellular endocrinology 1997;131(1):9-20.
1997: Walter Fiedler; Ullrich Graeven; Süleyman Ergün; S Verago; Nerbil Kilic; Marcus Stockschläder; Dieter K Hossfeld
Vascular endothelial growth factor, a possible paracrine growth factor in human acute myeloid leukemia.
Blood 1997;89(6):1870-5.
1997: William H Krüger; Marcus Stockschläder; Ingo Sobottka; R Betker; Maike de Wit; Nicolaus Kröger; Jan Grimm; M Arland; Walter Fiedler; Rudolf Erttmann; Axel R Zander
Antimycotic therapy with liposomal amphotericin-B for patients undergoing bone marrow or peripheral blood stem cell transplantation.
Leukemia & lymphoma 1997;24(5-6):491-9.
1997: Süleyman Ergün; W Empen; Walter Fiedler
VEGF modulates the capillaries of the human epididymis.
Advances in experimental medicine and biology 1997;424():189-90.
1997: Nerbil Kilic; Walter Fiedler; Adolf F Holstein; Süleyman Ergün
Expression of VEGF and its receptors and capillary density in Leydig cell tumors of the human testis.
Advances in experimental medicine and biology 1997;424():181-2.