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Leigh Field

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Meixia Dan; L Leigh Field; Dongjun Zheng; Vagn Bonnevie-Nielsen
Induction and activation of antiviral enzyme 2',5'-oligoadenylate synthetase by in vitro transcribed insulin mRNA and other cellular RNAs.
Sun J Choi; Mary L Marazita; P Suzanne Hart; Pawel P Sulima; L Leigh Field; Toby Goldstein McHenry; Manika Govil; Margaret E Cooper; Ariadne Letra; Renato Menezes; Somnya Narayanan; Maria Adela Mansilla; jose granjeiro; Alexandre R Vieira; Andrew C Lidral; Jeffrey C Murray; Thomas Hart
The PDGF-C regulatory region SNP rs28999109 decreases promoter transcriptional activity and is associated with CL/P.
Min Li; D-J Zheng; L Leigh Field; Vagn Bonnevie-Nielsen
Murine pancreatic beta TC3 cells show greater 2', 5'-oligoadenylate synthetase (2'5'AS) antiviral enzyme activity and apoptosis following IFN-alpha or poly(I:C) treatment than pancreatic alpha TC3 cells.

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All Publications

2012: Meixia Dan; L Leigh Field; Dongjun Zheng; Vagn Bonnevie-Nielsen
Induction and activation of antiviral enzyme 2',5'-oligoadenylate synthetase by in vitro transcribed insulin mRNA and other cellular RNAs.
Molecular biology reports 2012;39(7):7813-22.
2009: Sun J Choi; Mary L Marazita; P Suzanne Hart; Pawel P Sulima; L Leigh Field; Toby Goldstein McHenry; Manika Govil; Margaret E Cooper; Ariadne Letra; Renato Menezes; Somnya Narayanan; Maria Adela Mansilla; jose granjeiro; Alexandre R Vieira; Andrew C Lidral; Jeffrey C Murray; Thomas Hart
The PDGF-C regulatory region SNP rs28999109 decreases promoter transcriptional activity and is associated with CL/P.
European journal of human genetics : EJHG 2009;17(6):774-84.
2009: Min Li; D-J Zheng; L Leigh Field; Vagn Bonnevie-Nielsen
Murine pancreatic beta TC3 cells show greater 2', 5'-oligoadenylate synthetase (2'5'AS) antiviral enzyme activity and apoptosis following IFN-alpha or poly(I:C) treatment than pancreatic alpha TC3 cells.
Experimental diabetes research 2009;2009():631026.
2009: Mary L Marazita; Andrew C Lidral; Jeffrey C Murray; L Leigh Field; Brion S Maher; Toby Goldstein McHenry; Margaret E Cooper; Manika Govil; Sandra Daack-Hirsch; Bridget Riley; Astanand Jugessur; Temis Felix; Lina Morene; M Adela Mansilla; Alexandre R Vieira; Kim Doheny; Elizabeth Pugh; Consuelo Valencia-Ramirez; Mauricio Arcos-Burgos
Genome scan, fine-mapping, and candidate gene analysis of non-syndromic cleft lip with or without cleft palate reveals phenotype-specific differences in linkage and association results.
Human heredity 2009;68(3):151-70.
2007: Jane W Kimani; Min Shi; Sandra Daack-Hirsch; Kaare Christensen; Danilo Moretti-Ferreira; Mary L Marazita; L Leigh Field; John W Canady; Jeffrey C Murray
X-chromosome inactivation patterns in monozygotic twins and sib pairs discordant for nonsyndromic cleft lip and/or palate.
American journal of medical genetics. Part A 2007;143A(24):3267-72.
2005: L Leigh Field; Vagn Bonnevie-Nielsen; Flemming Pociot; Shao Lu; Thomas B Nielsen; Henning Beck-Nielsen
OAS1 splice site polymorphism controlling antiviral enzyme activity influences susceptibility to type 1 diabetes.
Diabetes 2005;54(5):1588-91.
2005: Vagn Bonnevie-Nielsen; L Leigh Field; Shao Lu; Dong-Jun Zheng; Min Li; Pia M Martensen; Thomas B Nielsen; Henning Beck-Nielsen; Yu-Lung Lau; Flemming Pociot
Variation in antiviral 2',5'-oligoadenylate synthetase (2'5'AS) enzyme activity is controlled by a single-nucleotide polymorphism at a splice-acceptor site in the OAS1 gene.
American journal of human genetics 2005;76(4):623-33.
2004: L Leigh Field; Ajit K Ray; Margaret E Cooper; Toby Goldstein; Diana F Shaw; Mary L Marazita
Genome scan for loci involved in nonsyndromic cleft lip with or without cleft palate in families from West Bengal, India.
American journal of medical genetics. Part A 2004;130A(3):265-71.
2004: Hao Ding; Xiaoli Wu; Hans Boström; Injune Kim; Nicole Wong; Bonny Tsoi; Meredith O'Rourke; Gou Young Koh; Philippe Soriano; Christer Betsholtz; Thomas Hart; Mary L Marazita; L Leigh Field; Patrick P L Tam; Andras Nagy
A specific requirement for PDGF-C in palate formation and PDGFR-alpha signaling.
Nature genetics 2004;36(10):1111-6.
2004: A K Ray; Mary L Marazita; R Pathak; C L Beever; Margaret E Cooper; Toby Goldstein; D F Shaw; L Leigh Field
TP63 mutation and clefting modifier genes in an EEC syndrome family.
Clinical genetics 2004;66(3):217-22.
2004: Theresa M Zucchero; Margaret E Cooper; Brion S Maher; Sandra Daack-Hirsch; Buena Nepomuceno; Lucilene Ribeiro; Diana Caprau; Kaare Christensen; Yasushi Suzuki; Junichiro Machida; Nagato Natsume; Koh-ichiro Yoshiura; Alexandre R Vieira; Iêda M Orioli; Eduardo E Castilla; Lina Moreno; Mauricio Arcos-Burgos; Andrew C Lidral; L Leigh Field; You-e Liu; Ajit Ray; Toby Goldstein; Rebecca E Schultz; Min Shi; Marla K Johnson; Shinji Kondo; Brian C Schutte; Mary L Marazita; Jeffrey C Murray
Interferon regulatory factor 6 (IRF6) gene variants and the risk of isolated cleft lip or palate.
The New England journal of medicine 2004;351(8):769-80.
2004: Mary L Marazita; Jeffrey C Murray; Andrew C Lidral; Mauricio Arcos-Burgos; Margaret E Cooper; Toby Goldstein; Brion S Maher; Sandra Daack-Hirsch; Rebecca Schultz; M Adela Mansilla; L Leigh Field; You-e Liu; Natalie Prescott; Sue Malcolm; Robin Winter; Ajit Ray; Lina Moreno; Consuelo Valencia; Katherine Neiswanger; Diego F Wyszynski; Joan E Bailey-Wilson; Hasan Albacha-Hejazi; Terri H beaty; Iain McIntosh; Jacqueline B Hetmanski; Gökhan Tunçbilek; Matthew Edwards; Louise Harkin; Rodney Scott; Laurence G Roddick
Meta-analysis of 13 genome scans reveals multiple cleft lip/palate genes with novel loci on 9q21 and 2q32-35.
American journal of human genetics 2004;75(2):161-73.
2004: Jordana Tzenova; Bonnie J Kaplan; Tracey L Petryshen; L Leigh Field
Confirmation of a dyslexia susceptibility locus on chromosome 1p34-p36 in a set of 100 Canadian families.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2004;127B(1):117-24.
2004: Mary L Marazita; L Leigh Field; Gökhan Tunçbilek; Margaret E Cooper; Toby Goldstein; K Gürler Gürsu
Genome-scan for loci involved in cleft lip with or without cleft palate in consanguineous families from Turkey.
American journal of medical genetics. Part A 2004;126A(2):111-22.
2004: Ging-Yuek R Hsiung; Bonnie J Kaplan; Tracey L Petryshen; Shao Lu; L Leigh Field
A dyslexia susceptibility locus (DYX7) linked to dopamine D4 receptor (DRD4) region on chromosome 11p15.5.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2004;125B(1):112-9.
2003: Supakit Peanchitlertkajorn; Margaret E Cooper; You-e Liu; L Leigh Field; Mary L Marazita
Chromosome 17: gene mapping studies of cleft lip with or without cleft palate in Chinese families.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association 2003;40(1):71-9.
2002: L Leigh Field; Zenia Marian Larsen; Flemming Pociot; Jørn Nerup; Rose Tobias; Vagn Bonnevie-Nielsen
Evidence for a locus (IDDM16) in the immunoglobulin heavy chain region on chromosome 14q32.3 producing susceptibility to type 1 diabetes.
Genes and immunity 2002;3(6):338-44.
2002: Mary L Marazita; L Leigh Field; Margaret E Cooper; Rose Tobias; Brion S Maher; Supakit Peanchitlertkajorn; You-e Liu
Genome scan for loci involved in cleft lip with or without cleft palate, in Chinese multiplex families.
American journal of human genetics 2002;71(2):349-64.
2002: Qinghua Shi; Elizabeth Spriggs; L Leigh Field; Alfred Rademaker; Evelyn Ko; Leona Barclay; Renée H Martin
Absence of age effect on meiotic recombination between human X and Y chromosomes.
American journal of human genetics 2002;71(2):254-61.
2002: Mary L Marazita; L Leigh Field; Margaret E Cooper; Rose Tobias; Brion S Maher; Supakit Peanchitlertkajorn; You-e Liu
Nonsyndromic cleft lip with or without cleft palate in China: assessment of candidate regions.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association 2002;39(2):149-56.
2002: Tracey L Petryshen; Bonnie J Kaplan; M L Hughes; J Tzenova; L Leigh Field
Supportive evidence for the DYX3 dyslexia susceptibility gene in Canadian families.
Journal of medical genetics 2002;39(2):125-6.
2002: L Leigh Field
Genetic linkage and association studies of Type I diabetes: challenges and rewards.
Diabetologia 2002;45(1):21-35.
2001: Tracey L Petryshen; Bonnie J Kaplan; M Fu Liu; N S de French; Rose Tobias; M L Hughes; L Leigh Field
Evidence for a susceptibility locus on chromosome 6q influencing phonological coding dyslexia.
American journal of medical genetics 2001;105(6):507-17.
2001: Renée H Martin; Q Shi; L Leigh Field
Recombination in the pseudoautosomal region in a 47,XYY male.
Human genetics 2001;109(2):143-5.
2001: Qinghua Shi; Elizabeth Spriggs; L Leigh Field; Evelyn Ko; Leona Barclay; Renée H Martin
Single sperm typing demonstrates that reduced recombination is associated with the production of aneuploid 24,XY human sperm.
American journal of medical genetics 2001;99(1):34-8.
2000: Tracey L Petryshen; Bonnie J Kaplan; M F Liu; L Leigh Field
Absence of significant linkage between phonological coding dyslexia and chromosome 6p23-21.3, as determined by use of quantitative-trait methods: confirmation of qualitative analyses.
American journal of human genetics 2000;66(2):708-14.
1998: L Leigh Field; Bonnie J Kaplan
Absence of linkage of phonological coding dyslexia to chromosome 6p23-p21.3 in a large family data set.
American journal of human genetics 1998;63(5):1448-56.
1998: L Leigh Field; Rose Tobias; W P Robinson; R Paisey; S Bain
Maternal uniparental disomy of chromosome 1 with no apparent phenotypic effects.
American journal of human genetics 1998;63(4):1216-20.
1998: N Torben Bech-Hansen; Kym M Boycott; K J Gratton; D A Ross; L Leigh Field; WG Pearce
Localization of a gene for incomplete X-linked congenital stationary night blindness to the interval between DXS6849 and DXS8023 in Xp11.23.
Human genetics 1998;103(2):124-30.
1997: Lisa F Barcellos; William Klitz; L Leigh Field; Rose Tobias; A M Bowcock; R Wilson; Mark P Nelson; J Nagatomi; Glenys Thomson
Association mapping of disease loci, by use of a pooled DNA genomic screen.
American journal of human genetics 1997;61(3):734-47.
1997: L Leigh Field; Rose Tobias
Unravelling a complex trait: the genetics of insulin-dependent diabetes mellitus.
Clinical and investigative medicine. Médecine clinique et experimentale 1997;20(1):41-9.
1996: L Leigh Field; R Tobias; G Thomson; S Plon
Susceptibility to insulin-dependent diabetes mellitus maps to a locus (IDDM11) on human chromosome 14q24.3-q31.
Genomics 1996;33(1):1-8.
1995: Susan G Crawford; Bonnie J Kaplan; L Leigh Field
Absence of an association between insulin-dependent diabetes mellitus and developmental learning difficulties.
Hereditas 1995;122(1):73-8.
1994: L Leigh Field; R Tobias; T Magnus
A locus on chromosome 15q26 (IDDM3) produces susceptibility to insulin-dependent diabetes mellitus.
Nature genetics 1994;8(2):189-94.
1994: L Leigh Field; A K Ray; Mary L Marazita
Transforming growth factor alpha: a modifying locus for nonsyndromic cleft lip with or without cleft palate?
European journal of human genetics : EJHG 1994;2(3):159-65.
1993: L L Stewart; L Leigh Field; S Ross; R G McArthur
Genetic risk factors in diabetic retinopathy.
Diabetologia 1993;36(12):1293-8.
1993: A K Ray; L Leigh Field; Mary L Marazita
Nonsyndromic cleft lip with or without cleft palate in west Bengal, India: evidence for an autosomal major locus.
American journal of human genetics 1993;52(5):1006-11.
1992: D I Hoar; L Leigh Field; F Beards; G Hoganson; B Rollnick; J J Hoo
Tentative assignment of gene for oto-palato-digital syndrome to distal Xq (Xq26-q28).
American journal of medical genetics 1992;42(2):170-2.
1991: L Leigh Field; David K Stephure; R G McArthur
Interaction between T cell receptor beta chain and immunoglobulin heavy chain region genes in susceptibility to insulin-dependent diabetes mellitus.
American journal of human genetics 1991;49(3):627-34.
1990: N Torben Bech-Hansen; L Leigh Field; A M Schramm; M Reedyk; IW Craig; N J Fraser; WG Pearce
A locus for X-linked congenital stationary night blindness is located on the proximal portion of the short arm of the X chromosome.
Human genetics 1990;84(5):406-8.
1990: K M Tynan; L Leigh Field; D I Hoar
Ethnic-specific allelic variation within the D1Z2 locus.
Human heredity 1990;40(1):1-14.
1989: Mary L Marazita; B J Keats; M A Spence; R S Sparkes; L Leigh Field; M C Sparkes; M Crist
Mapping studies of the serum cholinesterase-2 locus (CHE2).
Human genetics 1989;83(2):139-44.
1989: L Leigh Field; N Boyd; T J Bowen; J K Kelly; Lloyd R Sutherland
Genetic markers and inflammatory bowel disease: immunoglobulin allotypes (GM, KM) and protease inhibitor.
The American journal of gastroenterology 1989;84(7):753-5.
1989: L Leigh Field
Genes predisposing to IDDM in multiplex families.
Genetic epidemiology 1989;6(1):101-6.
1988: L Leigh Field
Insulin-dependent diabetes mellitus: a model for the study of multifactorial disorders.
American journal of human genetics 1988;43(6):793-8.
1988: L Leigh Field; J P Gofton; T D Kinsella
Immunoglobulin (GM and KM) allotypes and relation to population history in native peoples of British Columbia: Haida and Bella Coola.
American journal of physical anthropology 1988;76(2):155-63.
1988: L Leigh Field; S Surje; A K Ray
Immunoglobulin (GM and KM) allotypes in the Sikh population of India.
American journal of physical anthropology 1988;75(1):31-5.
1987: L Leigh Field; R G McArthur; S Y Shin; Ji-Won Yoon
The relationship between Coxsackie-B-virus-specific IgG responses and genetic factors (HLA-DR, GM, KM) in insulin-dependent diabetes mellitus.
Diabetes research (Edinburgh, Scotland) 1987;6(4):169-73.
1987: R G McArthur; L Leigh Field; Ji-Won Yoon; N Boyd; J M Graham
Diminished complications in a non DR3 DR4 family with insulin-dependent diabetes.
Clinical and investigative medicine. Médecine clinique et experimentale 1987;10(5):470-4.
1987: L Leigh Field; R G McArthur
The genetics of susceptibility to insulin-dependent diabetes mellitus--possible new markers.
Clinical and investigative medicine. Médecine clinique et experimentale 1987;10(5):437-43.
1987: L Leigh Field; R Tobias; T Bech-Hansen
SacI RFLP recognized by a human immunoglobulin kappa light chain constant region probe.
Nucleic acids research 1987;15(9):3942.
1986: L Leigh Field; M H Dizier; C E Anderson; M A Spence; J I Rotter
HLA-dependent GM effects in insulin-dependent diabetes: evidence from pairs of affected siblings.
American journal of human genetics 1986;39(5):640-7.
1985: M Crist; John R Heckenlively; L Leigh Field; M C Sparkes; C Farson; M A Spence; R S Sparkes
Glutamate pyruvate transaminase null allele (GPT0) in the Navajo.
Human heredity 1985;35(1):59-61.
1984: L Leigh Field; C E Anderson; Katherine Neiswanger; S E Hodge; M A Spence; J I Rotter
Interaction of HLA and immunoglobulin antigens in type 1 (insulin-dependent) diabetes.
Diabetologia 1984;27(5):504-8.
1984: L Leigh Field; C E Anderson; D L Rimoin
Inheritance of immunoglobulin light-chain genes in pairs of siblings with insulin-dependent diabetes mellitus.
Lancet 1984;1(8386):1132.
1984: R S Sparkes; L Leigh Field; M C Sparkes; M Crist; M A Spence; K James; P J Garry
Genetic linkage studies of transferrin, pseudocholinesterase, and chromosome 1 loci.
Human heredity 1984;34(2):96-100.
1984: M Anne-Spence; Catherine T Falk; Katherine Neiswanger; L Leigh Field; Mary L Marazita; F H Allen; R M Siervogel; A F Roche; B F Crandall; R S Sparkes
Estimating the recombination frequency for the PTC-Kell linkage.
Human genetics 1984;67(2):183-6.
1984: L Leigh Field; A Goldstein; M A Spence; C E Anderson; D L Rimoin
No evidence for linkage between an insulin-dependent diabetes mellitus-susceptibility locus and immunoglobulin loci KM or GM.
Genetic epidemiology 1984;1(4):375-82.
1984: M A Spence; L Leigh Field; Mary L Marazita; J Joseph; M Sparkes; M Crist; B F Crandall; C E Anderson; J B Bateman; J I Rotter
Estimating the recombination frequency for the MN and the Ss loci.
Human heredity 1984;34(6):343-7.
1983: M A Spence; J L Bader; D M Parry; L Leigh Field; S J Funderburk; A E Rubenstein; Priscilla Gilman; R S Sparkes
Linkage analysis of neurofibromatosis (von Recklinghausen disease).
Journal of medical genetics 1983;20(5):334-7.
1983: R S Sparkes; A L Murphree; R W Lingua; M C Sparkes; L Leigh Field; S J Funderburk; W F Benedict
Gene for hereditary retinoblastoma assigned to human chromosome 13 by linkage to esterase D.
Science (New York, N.Y.) 1983;219(4587):971-3.
1982: L Leigh Field; John R Heckenlively; R S Sparkes; C A Garcia; C Farson; D Zedalis; M C Sparkes; M Crist; S Tideman; M A Spence
Linkage analysis of five pedigrees affected with typical autosomal dominant retinitis pigmentosa.
Journal of medical genetics 1982;19(4):266-70.
1982: R D Robertson; M A Spence; R S Sparkes; Katherine Neiswanger; L Leigh Field
Linkage analysis with the trismus-pseudocamptodactyly syndrome.
American journal of medical genetics 1982;12(1):115-20.
1981: S E Hodge; C E Anderson; Katherine Neiswanger; L Leigh Field; M A Spence; R S Sparkes; M C Sparkes; M Crist; P I Terasaki; D L Rimoin; J I Rotter
Close genetic linkage between diabetes mellitus and kidd blood group.
Lancet 1981;2(8252):893-5.
1981: A K Ray; L Leigh Field
Immunoglobulin (Gm) allotypes in a sample of upper-caste Hindus from Bengal, India.
Human heredity 1981;31(6):358-62.