Carol Fierke

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Chemicals & Drugs

Concepts & Ideas

Phenomena

Physiology

Living Beings

Sign-in to see full Profile

Sign-in to see all Coauthors

Publications

TOP 3
Johnson Kathryn M; Swenson Lara; Opipari Anthony W; Reuter Rolf; Zarrabi Nawid; Fierke Carol A; Börsch Michael; Glick Gary D
Mechanistic basis for differential inhibition of the F1Fo-ATPase by aurovertin.
Hsieh John; Fierke Carol A
Conformational change in the Bacillus subtilis RNase P holoenzyme--pre-tRNA complex enhances substrate affinity and limits cleavage rate.
Hougland James L; Fierke Carol A
Getting a handle on protein prenylation.

Sign-in to see all Publications

Sign in free and see...

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the visualized research activity
of experts around the globe

Sign-in to see more

Geonetwork of Carol Fierke (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

Sign-in to see more

All Publications

2009: Johnson Kathryn M; Swenson Lara; Opipari Anthony W; Reuter Rolf; Zarrabi Nawid; Fierke Carol A; Börsch Michael; Glick Gary D
Mechanistic basis for differential inhibition of the F1Fo-ATPase by aurovertin.
Biopolymers 2009;91(10):830-40.
2009: Hsieh John; Fierke Carol A
Conformational change in the Bacillus subtilis RNase P holoenzyme--pre-tRNA complex enhances substrate affinity and limits cleavage rate.
RNA (New York, N.Y.) 2009;15(8):1565-77.
2009: Hougland James L; Fierke Carol A
Getting a handle on protein prenylation.
Nature chemical biology 2009;5(4):197-8.
2009: Hougland James L; Lamphear Corissa L; Scott Sarah A; Gibbs Richard A; Fierke Carol A
Context-Dependent Substrate Recognition by Protein Farnesyltransferase (dagger).
Biochemistry 2009;48(8):1691-701.
2009: Hsieh John; Walker Scott C; Fierke Carol A; Engelke David R
Pre-tRNA turnover catalyzed by the yeast nuclear RNase P holoenzyme is limited by product release.
RNA (New York, N.Y.) 2009;15(2):224-34.
2008: Lipton Andrew S; Heck Robert W; Hernick Marcy; Fierke Carol A; Ellis Paul D
Residue ionization in LpxC directly observed by 67Zn NMR spectroscopy.
Journal of the American Chemical Society 2008;130(38):12671-9.
2008: Mason Anne B; Judson Gregory L; Bravo Maria Cristina; Edelstein Andrew; Byrne Shaina L; James Nicholas G; Roush Eric D; Fierke Carol A; Bobst Cedric E; Kaltashov Igor A; Daughtery Margaret A
Evolution reversed: the ability to bind iron restored to the N-lobe of the murine inhibitor of carbonic anhydrase by strategic mutagenesis.
Biochemistry 2008;47(37):9847-55.
2008: Walters Matthew J; Srikannathasan Velupillai; McEwan Andrew R; Naismith James H; Fierke Carol A; Toone Eric J
Characterization and crystal structure of Escherichia coli KDPGal aldolase.
Bioorganic & medicinal chemistry 2008;16(2):710-20.
2008: Bozym Rebecca; Hurst Tamiika K; Westerberg Nissa; Stoddard Andrea; Fierke Carol A; Frederickson Christopher J; Thompson Richard B
Determination of zinc using carbonic anhydrase-based fluorescence biosensors.
Methods in enzymology 2008;450():287-309.
2008: Hernick Marcy; Fierke Carol A
A method to assay inhibitors of lipopolysaccharide synthesis.
Methods in molecular medicine 2008;142():143-54.
2007: Smith J Kristin; Hsieh John; Fierke Carol A
Importance of RNA-protein interactions in bacterial ribonuclease P structure and catalysis.
Biopolymers 2007;87(5-6):329-38.
2007: Inamdar Munish V; Lastoskie Christian M; Fierke Carol A; Sastry Ann Marie
Mobile trap algorithm for zinc detection using protein sensors.
The Journal of chemical physics 2007;127(18):185102.
2007: Cheriyan Manoj; Toone Eric J; Fierke Carol A
Mutagenesis of the phosphate-binding pocket of KDPG aldolase enhances selectivity for hydrophobic substrates.
Protein science : a publication of the Protein Society 2007;16(11):2368-77.
2007: Krzysiak Amanda J; Scott Sarah A; Hicks Katherine A; Fierke Carol A; Gibbs Richard A
Evaluation of protein farnesyltransferase substrate specificity using synthetic peptide libraries.
Bioorganic & medicinal chemistry letters 2007;17(20):5548-51.
2007: Krzysiak Amanda J; Rawat Diwan S; Scott Sarah A; Pais June E; Handley Misty; Harrison Marietta L; Fierke Carol A; Gibbs Richard A
Combinatorial modulation of protein prenylation.
ACS chemical biology 2007;2(6):385-9.
2007: Niranjanakumari Somashekarappa; Day-Storms Jeremy J; Ahmed Mahiuddin; Hsieh John; Zahler Nathan H; Venters Ronald A; Fierke Carol A
Probing the architecture of the B. subtilis RNase P holoenzyme active site by cross-linking and affinity cleavage.
RNA (New York, N.Y.) 2007;13(4):521-35.
2007: Getz Melissa M; Andrews Andy J; Fierke Carol A; Al-Hashimi Hashim M
Structural plasticity and Mg2+ binding properties of RNase P P4 from combined analysis of NMR residual dipolar couplings and motionally decoupled spin relaxation.
RNA (New York, N.Y.) 2007;13(2):251-66.
2006: Hernick Marcy; Fierke Carol A
Catalytic mechanism and molecular recognition of E. coli UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase probed by mutagenesis.
Biochemistry 2006;45(51):15240-8.
2006: Hernick Marcy; Fierke Carol A
Molecular recognition by Escherichia coli UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase is modulated by bound metal ions.
Biochemistry 2006;45(49):14573-81.
2006: Pais June E; Bowers Katherine E; Fierke Carol A
Measurement of the alpha-secondary kinetic isotope effect for the reaction catalyzed by mammalian protein farnesyltransferase.
Journal of the American Chemical Society 2006;128(47):15086-7.
2006: Gennadios Heather A; Whittington Douglas A; Li Xuechen; Fierke Carol A; Christianson David W
Mechanistic inferences from the binding of ligands to LpxC, a metal-dependent deacetylase.
Biochemistry 2006;45(26):7940-8.
2006: Johnson Kathryn M; Cleary Joanne; Fierke Carol A; Opipari Anthony W; Glick Gary D
Mechanistic basis for therapeutic targeting of the mitochondrial F1F0-ATPase.
ACS chemical biology 2006;1(5):304-8.
2006: Xiao Shaohua; Hsieh John; Nugent Rebecca L; Coughlin Daniel J; Fierke Carol A; Engelke David R
Functional characterization of the conserved amino acids in Pop1p, the largest common protein subunit of yeast RNases P and MRP.
RNA (New York, N.Y.) 2006;12(6):1023-37.
2006: Gantt Stephanie L; Gattis Samuel G; Fierke Carol A
Catalytic activity and inhibition of human histone deacetylase 8 is dependent on the identity of the active site metal ion.
Biochemistry 2006;45(19):6170-8.
2006: Fullerton Stephen W B; Griffiths Jennifer S; Merkel Alexandra B; Cheriyan Manoj; Wymer Nathan J; Hutchins Michael J; Fierke Carol A; Toone Eric J; Naismith James H
Mechanism of the Class I KDPG aldolase.
Bioorganic & medicinal chemistry 2006;14(9):3002-10.
2006: Bozym Rebecca A; Thompson Richard B; Stoddard Andrea K; Fierke Carol A
Measuring picomolar intracellular exchangeable zinc in PC-12 cells using a ratiometric fluorescence biosensor.
ACS chemical biology 2006;1(2):103-11.
2006: Sumner James P; Westerberg Nissa M; Stoddard Andrea K; Hurst Tamiika K; Cramer Michele; Thompson Richard B; Fierke Carol A; Kopelman Raoul
DsRed as a highly sensitive, selective, and reversible fluorescence-based biosensor for both Cu(+) and Cu(2+) ions.
Biosensors & bioelectronics 2006;21(7):1302-8.
2005: Rueda David; Hsieh John; Day-Storms Jeremy J; Fierke Carol A; Walter Nils G
The 5' leader of precursor tRNAAsp bound to the Bacillus subtilis RNase P holoenzyme has an extended conformation.
Biochemistry 2005;44(49):16130-9.
2005: Hicks Katherine A; Hartman Heather L; Fierke Carol A
Upstream polybasic region in peptides enhances dual specificity for prenylation by both farnesyltransferase and geranylgeranyltransferase type I.
Biochemistry 2005;44(46):15325-33.
2005: Hartman Heather L; Hicks Katherine A; Fierke Carol A
Peptide specificity of protein prenyltransferases is determined mainly by reactivity rather than binding affinity.
Biochemistry 2005;44(46):15314-24.
2005: Pais June E; Bowers Katherine E; Stoddard Andrea K; Fierke Carol A
A continuous fluorescent assay for protein prenyltransferases measuring diphosphate release.
Analytical biochemistry 2005;345(2):302-11.
2005: Reigard Sarah A; Zahn Todd J; Haworth Kellie B; Hicks Katherine A; Fierke Carol A; Gibbs Richard A
Interplay of isoprenoid and peptide substrate specificity in protein farnesyltransferase.
Biochemistry 2005;44(33):11214-23.
2005: Xiao Shaohua; Day-Storms Jeremy J; Srisawat Chatchawan; Fierke Carol A; Engelke David R
Characterization of conserved sequence elements in eukaryotic RNase P RNA reveals roles in holoenzyme assembly and tRNA processing.
RNA (New York, N.Y.) 2005;11(6):885-96.
2005: Hernick Marcy; Gennadios Heather A; Whittington Douglas A; Rusche Kristin M; Christianson David W; Fierke Carol A
UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase functions through a general acid-base catalyst pair mechanism.
The Journal of biological chemistry 2005;280(17):16969-78.
2005: Hernick Marcy; Fierke Carol A
Zinc hydrolases: the mechanisms of zinc-dependent deacetylases.
Archives of biochemistry and biophysics 2005;433(1):71-84.
2004: Day-Storms Jeremy J; Niranjanakumari S; Fierke Carol A
Ionic interactions between PRNA and P protein in Bacillus subtilis RNase P characterized using a magnetocapture-based assay.
RNA (New York, N.Y.) 2004;10(10):1595-608.
2004: Griffiths Jennifer S; Cheriyan Manoj; Corbell Jayme B; Pocivavsek Luka; Fierke Carol A; Toone Eric J
A bacterial selection for the directed evolution of pyruvate aldolases.
Bioorganic & medicinal chemistry 2004;12(15):4067-74.
2004: Hartman Heather L; Bowers Katherine E; Fierke Carol A
Lysine beta311 of protein geranylgeranyltransferase type I partially replaces magnesium.
The Journal of biological chemistry 2004;279(29):30546-53.
2004: Bowers Katherine E; Fierke Carol A
Positively charged side chains in protein farnesyltransferase enhance catalysis by stabilizing the formation of the diphosphate leaving group.
Biochemistry 2004;43(18):5256-65.
2004: McCall Keith A; Fierke Carol A
Probing determinants of the metal ion selectivity in carbonic anhydrase using mutagenesis.
Biochemistry 2004;43(13):3979-86.
2004: Hsieh John; Andrews Andy J; Fierke Carol A
Roles of protein subunits in RNA-protein complexes: lessons from ribonuclease P.
Biopolymers 2004;73(1):79-89.
2003: Zeng Hui-Hui; Thompson Richard B; Maliwal Badri P; Fones Gary R; Moffett James W; Fierke Carol A
Real-time determination of picomolar free Cu(II) in seawater using a fluorescence-based fiber optic biosensor.
Analytical chemistry 2003;75(24):6807-12.
2003: Pickett Jennifer S; Bowers Katherine E; Fierke Carol A
Mutagenesis studies of protein farnesyltransferase implicate aspartate beta 352 as a magnesium ligand.
The Journal of biological chemistry 2003;278(51):51243-50.
2003: Tobin Daniel A; Pickett Jennifer S; Hartman Heather L; Fierke Carol A; Penner-Hahn James E
Structural characterization of the zinc site in protein farnesyltransferase.
Journal of the American Chemical Society 2003;125(33):9962-9.
2003: Pickett Jennifer S; Bowers Katherine E; Hartman Heather L; Fu Hua-Wen; Embry Alan C; Casey Patrick J; Fierke Carol A
Kinetic studies of protein farnesyltransferase mutants establish active substrate conformation.
Biochemistry 2003;42(32):9741-8.
2003: Whittington Douglas A; Rusche Kristin M; Shin Hyunshun; Fierke Carol A; Christianson David W
Crystal structure of LpxC, a zinc-dependent deacetylase essential for endotoxin biosynthesis.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(14):8146-50.
2003: McClure Craig P; Rusche Kristin M; Peariso Katrina; Jackman Jane E; Fierke Carol A; Penner-Hahn James E
EXAFS studies of the zinc sites of UDP-(3-O-acyl)-N-acetylglucosamine deacetylase (LpxC).
Journal of inorganic biochemistry 2003;94(1-2):78-85.
2003: Shao Feng; Vacratsis Panayiotis O; Bao Zhaoqin; Bowers Katherine E; Fierke Carol A; Dixon Jack E
Biochemical characterization of the Yersinia YopT protease: cleavage site and recognition elements in Rho GTPases.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(3):904-9.
2002: Pirrung Michael C; Tumey L Nathan; Raetz Christian R H; Jackman Jane E; Snehalatha Karnem; McClerren Amanda L; Fierke Carol A; Gantt Stephanie L; Rusche Kristin M
Inhibition of the antibacterial target UDP-(3-O-acyl)-N-acetylglucosamine deacetylase (LpxC): isoxazoline zinc amidase inhibitors bearing diverse metal binding groups.
Journal of medicinal chemistry 2002;45(19):4359-70.
2002: Thompson R B; Peterson Dwight; Mahoney William; Cramer Michele; Maliwal Badri P; Suh Sang Won; Frederickson Chris; Fierke Carol; Herman Petr
Fluorescent zinc indicators for neurobiology.
Journal of neuroscience methods 2002;118(1):63-75.
2002: Crary Sharon M; Kurz Jeffrey C; Fierke Carol A
Specific phosphorothioate substitutions probe the active site of Bacillus subtilis ribonuclease P.
RNA (New York, N.Y.) 2002;8(7):933-47.
2002: Kurz Jeffrey C; Fierke Carol A
The affinity of magnesium binding sites in the Bacillus subtilis RNase P x pre-tRNA complex is enhanced by the protein subunit.
Biochemistry 2002;41(30):9545-58.
2002: Chehade Kareem A H; Kiegiel Katarzyna; Isaacs Richard J; Pickett Jennifer S; Bowers Katherine E; Fierke Carol A; Andres Douglas A; Spielmann H Peter
Photoaffinity analogues of farnesyl pyrophosphate transferable by protein farnesyl transferase.
Journal of the American Chemical Society 2002;124(28):8206-19.
2002: Griffiths Jennifer S; Wymer Nathan J; Njolito Eugenia; Niranjanakumari S; Fierke Carol A; Toone Eric J
Cloning, isolation and characterization of the Thermotoga maritima KDPG aldolase.
Bioorganic & medicinal chemistry 2002;10(3):545-50.
2002: Madder Ryan D; Kim Chu-Young; Chandra Pooja P; Doyon Jeffrey B; Baird Teaster A; Fierke Carol A; Christianson David W; Voet Judith G; Jain Ahamindra
Twisted amides inferred from QSAR analysis of hydrophobicity and electronic effects on the affinity of fluoroaromatic inhibitors of carbonic anhydrase.
The Journal of organic chemistry 2002;67(2):582-4.
2002: Xiao Shaohua; Scott Felicia; Fierke Carol A; Engelke David R
Eukaryotic ribonuclease P: a plurality of ribonucleoprotein enzymes.
Annual review of biochemistry 2002;71():165-89.
2001: Fierke C A; Thompson R B
Fluorescence-based biosensing of zinc using carbonic anhydrase.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 2001;14(3-4):205-22.
2001: DiTusa C A; McCall K A; Christensen T; Mahapatro M; Fierke C A; Toone E J
Thermodynamics of metal ion binding. 2. Metal ion binding by carbonic anhydrase variants.
Biochemistry 2001;40(18):5345-51.
2001: DiTusa C A; Christensen T; McCall K A; Fierke C A; Toone E J
Thermodynamics of metal ion binding. 1. Metal ion binding by wild-type carbonic anhydrase.
Biochemistry 2001;40(18):5338-44.
2001: Henkels C H; Kurz J C; Fierke C A; Oas T G
Linked folding and anion binding of the Bacillus subtilis ribonuclease P protein.
Biochemistry 2001;40(9):2777-89.
2001: Fang X W; Yang X J; Littrell K; Niranjanakumari S; Thiyagarajan P; Fierke C A; Sosnick T R; Pan T
The Bacillus subtilis RNase P holoenzyme contains two RNase P RNA and two RNase P protein subunits.
RNA (New York, N.Y.) 2001;7(2):233-41.
2001: Wymer N; Buchanan L V; Henderson D; Mehta N; Botting C H; Pocivavsek L; Fierke C A; Toone E J; Naismith J H
Directed evolution of a new catalytic site in 2-keto-3-deoxy-6-phosphogluconate aldolase from Escherichia coli.
Structure (London, England : 1993) 2001;9(1):1-9.
2001: Hightower K E; Casey P J; Fierke C A
Farnesylation of nonpeptidic thiol compounds by protein farnesyltransferase.
Biochemistry 2001;40(4):1002-10.
2001: Jackman J E; Raetz C R; Fierke C A
Site-directed mutagenesis of the bacterial metalloamidase UDP-(3-O-acyl)-N-acetylglucosamine deacetylase (LpxC). Identification of the zinc binding site.
Biochemistry 2001;40(2):514-23.
2000: Cox J D; Hunt J A; Compher K M; Fierke C A; Christianson D W
Structural influence of hydrophobic core residues on metal binding and specificity in carbonic anhydrase II.
Biochemistry 2000;39(45):13687-94.
2000: Spence R A; Hightower K E; Terry K L; Beese L S; Fierke C A; Casey P J
Conversion of Tyr361 beta to Leu in mammalian protein farnesyltransferase impairs product release but not substrate recognition.
Biochemistry 2000;39(45):13651-9.
2000: Saderholm M J; Hightower K E; Fierke C A
Role of metals in the reaction catalyzed by protein farnesyltransferase.
Biochemistry 2000;39(40):12398-405.
2000: Kurz J C; Fierke C A
Ribonuclease P: a ribonucleoprotein enzyme.
Current opinion in chemical biology 2000;4(5):553-8.
2000: McCall K A; Fierke C A
Colorimetric and fluorimetric assays to quantitate micromolar concentrations of transition metals.
Analytical biochemistry 2000;284(2):307-15.
2000: Ziehler W A; Day J J; Fierke C A; Engelke D R
Effects of 5' leader and 3' trailer structures on pre-tRNA processing by nuclear RNase P.
Biochemistry 2000;39(32):9909-16.
2000: Doyon J B; Hansen E A; Kim C Y; Chang J S; Christianson D W; Madder R D; Voet J G; Baird T A; Fierke C A; Jain A
Linear free energy relationships implicate three modes of binding for fluoroaromatic inhibitors to a mutant of carbonic anhydrase II.
Organic letters 2000;2(9):1189-92.
2000: McCall K A; Huang C; Fierke C A
Function and mechanism of zinc metalloenzymes.
The Journal of nutrition 2000;130(5S Suppl):1437S-46S.
2000: Burton R E; Hunt J A; Fierke C A; Oas T G
Novel disulfide engineering in human carbonic anhydrase II using the PAIRWISE side-chain geometry database.
Protein science : a publication of the Protein Society 2000;9(4):776-85.
2000: Jackman J E; Fierke C A; Tumey L N; Pirrung M; Uchiyama T; Tahir S H; Hindsgaul O; Raetz C R
Antibacterial agents that target lipid A biosynthesis in gram-negative bacteria. Inhibition of diverse UDP-3-O-(r-3-hydroxymyristoyl)-n-acetylglucosamine deacetylases by substrate analogs containing zinc binding motifs.
The Journal of biological chemistry 2000;275(15):11002-9.
2000: Thompson R B; Whetsell W O; Maliwal B P; Fierke C A; Frederickson C J
Fluorescence microscopy of stimulated Zn(II) release from organotypic cultures of mammalian hippocampus using a carbonic anhydrase-based biosensor system.
Journal of neuroscience methods 2000;96(1):35-45.
2000: Huang C; Hightower K E; Fierke C A
Mechanistic studies of rat protein farnesyltransferase indicate an associative transition state.
Biochemistry 2000;39(10):2593-602.
2000: Hunt J A; Lesburg C A; Christianson D W; Thompson R B; Fierke C A
Active-site engineering of carbonic anhydrase and its application to biosensors.
EXS 2000;(90):221-40.
1999: Alber B E; Colangelo C M; Dong J; Stålhandske C M; Baird T T; Tu C; Fierke C A; Silverman D N; Scott R A; Ferry J G
Kinetic and spectroscopic characterization of the gamma-carbonic anhydrase from the methanoarchaeon Methanosarcina thermophila.
Biochemistry 1999;38(40):13119-28.
1999: Hunt J A; Ahmed M; Fierke C A
Metal binding specificity in carbonic anhydrase is influenced by conserved hydrophobic core residues.
Biochemistry 1999;38(28):9054-62.
1999: Hightower K E; Fierke C A
Zinc-catalyzed sulfur alkyation:insights from protein farnesyltransferase.
Current opinion in chemical biology 1999;3(2):176-81.
1999: Jackman J E; Raetz C R; Fierke C A
UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase of Escherichia coli is a zinc metalloenzyme.
Biochemistry 1999;38(6):1902-11.
1999: Thompson R B; Maliwal B P; Fierke C A
Selectivity and sensitivity of fluorescence lifetime-based metal ion biosensing using a carbonic anhydrase transducer.
Analytical biochemistry 1999;267(1):185-95.
1998: Niranjanakumari S; Stams T; Crary S M; Christianson D W; Fierke C A
Protein component of the ribozyme ribonuclease P alters substrate recognition by directly contacting precursor tRNA.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(26):15212-7.
1998: Thompson R B; Maliwal B P; Feliccia V L; Fierke C A; McCall K
Determination of picomolar concentrations of metal ions using fluorescence anisotropy: biosensing with a "reagentless" enzyme transducer.
Analytical chemistry 1998;70(22):4717-23.
1998: Hightower K E; Huang C C; Casey P J; Fierke C A
H-Ras peptide and protein substrates bind protein farnesyltransferase as an ionized thiolate.
Biochemistry 1998;37(44):15555-62.
1998: Loria A; Niranjanakumari S; Fierke C A; Pan T
Recognition of a pre-tRNA substrate by the Bacillus subtilis RNase P holoenzyme.
Biochemistry 1998;37(44):15466-73.
1998: Niranjanakumari S; Kurz J C; Fierke C A
Expression, purification and characterization of the recombinant ribonuclease P protein component from Bacillus subtilis.
Nucleic acids research 1998;26(13):3090-6.
1998: Crary S M; Niranjanakumari S; Fierke C A
The protein component of Bacillus subtilis ribonuclease P increases catalytic efficiency by enhancing interactions with the 5' leader sequence of pre-tRNAAsp.
Biochemistry 1998;37(26):9409-16.
1998: Stams T; Niranjanakumari S; Fierke C A; Christianson D W
Ribonuclease P protein structure: evolutionary origins in the translational apparatus.
Science (New York, N.Y.) 1998;280(5364):752-5.
1998: Kurz J C; Niranjanakumari S; Fierke C A
Protein component of Bacillus subtilis RNase P specifically enhances the affinity for precursor-tRNAAsp.
Biochemistry 1998;37(8):2393-400.
1997: Lesburg C A; Huang C; Christianson D W; Fierke C A
Histidine --> carboxamide ligand substitutions in the zinc binding site of carbonic anhydrase II alter metal coordination geometry but retain catalytic activity.
Biochemistry 1997;36(50):15780-91.
1997: Hunt J A; Fierke C A
Selection of carbonic anhydrase variants displayed on phage. Aromatic residues in zinc binding site enhance metal affinity and equilibration kinetics.
The Journal of biological chemistry 1997;272(33):20364-72.
1997: Wuebbens M W; Roush E D; Decastro C M; Fierke C A
Cloning, sequencing, and recombinant expression of the porcine inhibitor of carbonic anhydrase: a novel member of the transferrin family.
Biochemistry 1997;36(14):4327-36.
1997: Baird T T; Waheed A; Okuyama T; Sly W S; Fierke C A
Catalysis and inhibition of human carbonic anhydrase IV.
Biochemistry 1997;36(9):2669-78.
1997: Huang C C; Casey P J; Fierke C A
Evidence for a catalytic role of zinc in protein farnesyltransferase. Spectroscopy of Co2+-farnesyltransferase indicates metal coordination of the substrate thiolate.
The Journal of biological chemistry 1997;272(1):20-3.
1996: Venters R A; Farmer B T; Fierke C A; Spicer L D
Characterizing the use of perdeuteration in NMR studies of large proteins: 13C, 15N and 1H assignments of human carbonic anhydrase II.
Journal of molecular biology 1996;264(5):1101-16.
1996: Jackman J E; Merz K M; Fierke C A
Disruption of the active site solvent network in carbonic anhydrase II decreases the efficiency of proton transfer.
Biochemistry 1996;35(51):16421-8.
1996: Beebe J A; Kurz J C; Fierke C A
Magnesium ions are required by Bacillus subtilis ribonuclease P RNA for both binding and cleaving precursor tRNAAsp.
Biochemistry 1996;35(32):10493-505.
1996: Huang C C; Lesburg C A; Kiefer L L; Fierke C A; Christianson D W
Reversal of the hydrogen bond to zinc ligand histidine-119 dramatically diminishes catalysis and enhances metal equilibration kinetics in carbonic anhydrase II.
Biochemistry 1996;35(11):3439-46.
1995: Ippolito J A; Nair S K; Alexander R S; Kiefer L L; Fierke C A; Christianson D W
Structure of His94-->Asp carbonic anhydrase II in a new crystalline form reveals a partially occupied zinc binding site.
Protein engineering 1995;8(10):975-80.
1995: Venters R A; Huang C C; Farmer B T; Trolard R; Spicer L D; Fierke C A
High-level 2H/13C/15N labeling of proteins for NMR studies.
Journal of biomolecular NMR 1995;5(4):339-44.
1995: Ippolito J A; Baird T T; McGee S A; Christianson D W; Fierke C A
Structure-assisted redesign of a protein-zinc-binding site with femtomolar affinity.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(11):5017-21.
1995: Nair S K; Krebs J F; Christianson D W; Fierke C A
Structural basis of inhibitor affinity to variants of human carbonic anhydrase II.
Biochemistry 1995;34(12):3981-9.
1995: Puttaraju M; Beebe J A; Niranjanakumari S; Been M D; Fierke C A
Generation and characterization of circular Bacillus subtilis RNase P RNA; activation by RNase P protein.
Nucleic acids symposium series 1995;(33):92-4.
1995: Fierke C A; Hammes G G
Transient kinetic approaches to enzyme mechanisms.
Methods in enzymology 1995;249():3-37.
1994: Kiefer L L; Fierke C A
Functional characterization of human carbonic anhydrase II variants with altered zinc binding sites.
Biochemistry 1994;33(51):15233-40.
1994: Beebe J A; Fierke C A
A kinetic mechanism for cleavage of precursor tRNA(Asp) catalyzed by the RNA component of Bacillus subtilis ribonuclease P.
Biochemistry 1994;33(34):10294-304.
1993: Krebs J F; Ippolito J A; Christianson D W; Fierke C A
Structural and functional importance of a conserved hydrogen bond network in human carbonic anhydrase II.
The Journal of biological chemistry 1993;268(36):27458-66.
1993: Heming T A; Vanoye C G; Stabenau E K; Roush E D; Fierke C A; Bidani A
Inhibitor sensitivity of pulmonary vascular carbonic anhydrase.
Journal of applied physiology (Bethesda, Md. : 1985) 1993;75(4):1642-9.
1993: Tweedy N B; Nair S K; Paterno S A; Fierke C A; Christianson D W
Structure and energetics of a non-proline cis-peptidyl linkage in a proline-202-->alanine carbonic anhydrase II variant.
Biochemistry 1993;32(41):10944-9.
1993: Kiefer L L; Krebs J F; Paterno S A; Fierke C A
Engineering a cysteine ligand into the zinc binding site of human carbonic anhydrase II.
Biochemistry 1993;32(38):9896-900.
1993: Krebs J F; Rana F; Dluhy R A; Fierke C A
Kinetic and spectroscopic studies of hydrophilic amino acid substitutions in the hydrophobic pocket of human carbonic anhydrase II.
Biochemistry 1993;32(17):4496-505.
1993: Alexander R S; Kiefer L L; Fierke C A; Christianson D W
Engineering the zinc binding site of human carbonic anhydrase II: structure of the His-94-->Cys apoenzyme in a new crystalline form.
Biochemistry 1993;32(6):1510-8.
1993: Krebs J F; Fierke C A
Determinants of catalytic activity and stability of carbonic anhydrase II as revealed by random mutagenesis.
The Journal of biological chemistry 1993;268(2):948-54.
1992: Roush E D; Fierke C A
Purification and characterization of a carbonic anhydrase II inhibitor from porcine plasma.
Biochemistry 1992;31(49):12536-42.
1991: Adams J A; Fierke C A; Benkovic S J
The function of amino acid residues contacting the nicotinamide ring of NADPH in dihydrofolate reductase from Escherichia coli.
Biochemistry 1991;30(46):11046-54.
1991: Fierke C A; Calderone T L; Krebs J F
Functional consequences of engineering the hydrophobic pocket of carbonic anhydrase II.
Biochemistry 1991;30(46):11054-63.
1991: Nair S K; Calderone T L; Christianson D W; Fierke C A
Altering the mouth of a hydrophobic pocket. Structure and kinetics of human carbonic anhydrase II mutants at residue Val-121.
The Journal of biological chemistry 1991;266(26):17320-5.
1991: Krebs J F; Fierke C A; Alexander R S; Christianson D W
Conformational mobility of His-64 in the Thr-200----Ser mutant of human carbonic anhydrase II.
Biochemistry 1991;30(38):9153-60.
1991: Venters R A; Calderone T L; Spicer L D; Fierke C A
Uniform 13C isotope labeling of proteins with sodium acetate for NMR studies: application to human carbonic anhydrase II.
Biochemistry 1991;30(18):4491-4.
1989: Andrews J; Fierke C A; Birdsall B; Ostler G; Feeney J; Roberts G C; Benkovic S J
A kinetic study of wild-type and mutant dihydrofolate reductases from Lactobacillus casei.
Biochemistry 1989;28(14):5743-50.
1989: Fierke C A; Benkovic S J
Probing the functional role of threonine-113 of Escherichia coli dihydrofolate reductase for its effect on turnover efficiency, catalysis, and binding.
Biochemistry 1989;28(2):478-86.
1988: Benkovic S J; Fierke C A; Naylor A M
Insights into enzyme function from studies on mutants of dihydrofolate reductase.
Science (New York, N.Y.) 1988;239(4844):1105-10.
1987: Fierke C A; Johnson K A; Benkovic S J
Construction and evaluation of the kinetic scheme associated with dihydrofolate reductase from Escherichia coli.
Biochemistry 1987;26(13):4085-92.
1987: Fierke C A; Kuchta R D; Johnson K A; Benkovic S J
Implications for enzymic catalysis from free-energy reaction coordinate profiles.
Cold Spring Harbor symposia on quantitative biology 1987;52():631-8.

Sign-in to see more

Sign-in free and Explore the Exciting World of BiomedExperts:

NetworkView

Carol Fierke

Research Profile (preview)

Chemicals & Drugs

Concepts & Ideas

Phenomena

Physiology

Living Beings

Network (preview)

Publications

Sign in free and see...

Visualized networks:

GeoTargeted Searches:

Research Profiles:

Geonetwork of Carol Fierke (preview)

All Publications