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Walter Fiers

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Sarah De Baets; Walter Fiers; Kenny Roose; Bert Schepens; Michael Schotsaert; Koen Sedeyn; Pieter Bogaert; Xavier Saelens
Recombinant influenza virus carrying the respiratory syncytial virus (RSV) F85-93 CTL epitope reduces RSV replication in mice.
Michael Schotsaert; T Ysenbaert; Bert Schepens; P Bogaert; Walter Fiers; L I Ibañez; Bart N Lambrecht; K Neyt; Xavier Saelens
Natural and long-lasting cellular immune responses against influenza in the M2e-immune host.
Hana Kammoun; Marina De Filette; Anne-Sophie Debrie; Walter Fiers; Nathalie Mielcarek; Dominique Raze; Xavier Roux; Xavier Saelens; Tine Ysenbaert; Camille Locht
Immunogenicity of Live Attenuated B. pertussis BPZE1 Producing the Universal Influenza Vaccine Candidate M2e.

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2013: Sarah De Baets; Walter Fiers; Kenny Roose; Bert Schepens; Michael Schotsaert; Koen Sedeyn; Pieter Bogaert; Xavier Saelens
Recombinant influenza virus carrying the respiratory syncytial virus (RSV) F85-93 CTL epitope reduces RSV replication in mice.
Journal of virology 2013;87(6):3314-23.
2013: Michael Schotsaert; T Ysenbaert; Bert Schepens; P Bogaert; Walter Fiers; L I Ibañez; Bart N Lambrecht; K Neyt; Xavier Saelens
Natural and long-lasting cellular immune responses against influenza in the M2e-immune host.
Mucosal immunology 2013;6(2):276-87.
2013: Hana Kammoun; Marina De Filette; Anne-Sophie Debrie; Walter Fiers; Nathalie Mielcarek; Dominique Raze; Xavier Roux; Xavier Saelens; Tine Ysenbaert; Camille Locht
Immunogenicity of Live Attenuated B. pertussis BPZE1 Producing the Universal Influenza Vaccine Candidate M2e.
PloS one 2013;8(3):e59198.
2013: Lorena Itatí Ibañez; Charlotte Pollard; Stefan Roels; Kenny Roose; Marina De Filette; Jessica De Sloovere; Walter Fiers; Johan Grooten; Bert Schepens; Michael Schotsaert; Xavier Saelens
M2e-displaying virus-like particles with associated RNA promote T helper 1 type adaptive immunity against influenza A.
PloS one 2013;8(3):e59081.
2012: Judith Verhelst; Bert Schepens; Walter Fiers; Eef Parthoens; Xavier Saelens
Interferon-inducible protein Mx1 inhibits influenza virus by interfering with functional viral ribonucleoprotein complex assembly.
Journal of virology 2012;86(24):13445-55.
2011: Dubravka Grdic Eliasson; Anja Helgeby; Karin Schön; Caroline Nygren; Karim El Bakkouri; Walter Fiers; Xavier Saelens; Karin Bengtsson Lövgren; Ida Nyström; Nils Lycke
A novel non-toxic combined CTA1-DD and ISCOMS adjuvant vector for effective mucosal immunization against influenza virus.
Vaccine 2011;29(23):3951-61.
2011: Marina De Filette; Tine Ysenbaert; Kenny Roose; Michael Schotsaert; Stefan Roels; Els Goossens; Bert Schepens; Walter Fiers; Xavier Saelens
Antiserum against the conserved nine amino acid N-terminal peptide of influenza A virus matrix protein 2 is not immunoprotective.
The Journal of general virology 2011;92(Pt 2):301-6.
2011: Karim El Bakkouri; Francis Descamps; Marina De Filette; Anouk Smet; Els Festjens; Ashley Birkett; Nico van Rooijen; Sjef Verbeek; Walter Fiers; Xavier Saelens
Universal vaccine based on ectodomain of matrix protein 2 of influenza A: Fc receptors and alveolar macrophages mediate protection.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(2):1022-31.
2010: Michael Schotsaert; Lorena Itatí Ibañez; Walter Fiers; Xavier Saelens
Controlling influenza by cytotoxic T-cells: calling for help from destroyers.
Journal of biomedicine & biotechnology 2010;2010():863985.
2009: Walter Fiers; Marina De Filette; Karim El Bakkouri; Bert Schepens; Kenny Roose; Michael Schotsaert; Ashley Birkett; Xavier Saelens
M2e-based universal influenza A vaccine.
Vaccine 2009;27(45):6280-3.
2009: Michael Schotsaert; Marina De Filette; Walter Fiers; Xavier Saelens
Universal M2 ectodomain-based influenza A vaccines: preclinical and clinical developments.
Expert review of vaccines 2009;8(4):499-508.
2009: Kenny Roose; Walter Fiers; Xavier Saelens
Pandemic preparedness: toward a universal influenza vaccine.
Drug news & perspectives 2009;22(2):80-92.
2008: Marina De Filette; Wouter Martens; Anouk Smet; Michael Schotsaert; Ashley Birkett; Patricia Londoño-Arcila; Walter Fiers; Xavier Saelens
Universal influenza A M2e-HBc vaccine protects against disease even in the presence of pre-existing anti-HBc antibodies.
Vaccine 2008;26(51):6503-7.
2008: Marina De Filette; Wouter Martens; Kenny Roose; Tom Deroo; Frederik Vervalle; Mostafa Bentahir; Joel Vandekerckhove; Walter Fiers; Xavier Saelens
An influenza A vaccine based on tetrameric ectodomain of matrix protein 2.
The Journal of biological chemistry 2008;283(17):11382-7.
2008: Dubravka Grdic Eliasson; Karim El Bakkouri; Karin Schön; Anna Ramne; Els Festjens; Björn Löwenadler; Walter Fiers; Xavier Saelens; Nils Lycke
CTA1-M2e-DD: a novel mucosal adjuvant targeted influenza vaccine.
Vaccine 2008;26(9):1243-52.
2006: Marina De Filette; Walter Fiers; Wouter Martens; Ashley Birkett; Anna Ramne; Björn Löwenadler; Nils Lycke; Willy Min Jou; Xavier Saelens
Improved design and intranasal delivery of an M2e-based human influenza A vaccine.
Vaccine 2006;24(44-46):6597-601.
2006: Marina De Filette; Anna Ramne; Ashley Birkett; Nils Lycke; Björn Löwenadler; Willy Min Jou; Xavier Saelens; Walter Fiers
The universal influenza vaccine M2e-HBc administered intranasally in combination with the adjuvant CTA1-DD provides complete protection.
Vaccine 2006;24(5):544-51.
2005: Marina De Filette; Willy Min Jou; Ashley Birkett; Katie Lyons; Brian Schultz; Anne Tonkyro; Stephanie Resch; Walter Fiers
Universal influenza A vaccine: optimization of M2-based constructs.
Virology 2005;337(1):149-61.
2004: Walter Fiers; Marina De Filette; Ashley Birkett; Sabine Neirynck; Willy Min Jou
A "universal" human influenza A vaccine.
Virus research 2004;103(1-2):173-6.
2004: Peter Brouckaert; Nozomi Takahashi; Sandra T van Tiel; Jeroen Hostens; Alexander M M Eggermont; Ann L B Seynhaeve; Walter Fiers; Timo L M ten Hagen
Tumor necrosis factor-alpha augmented tumor response in B16BL6 melanoma-bearing mice treated with stealth liposomal doxorubicin (Doxil) correlates with altered Doxil pharmacokinetics.
International journal of cancer. Journal international du cancer 2004;109(3):442-8.
2002: Paul Ameloot; Nozomi Takahashi; Bart Everaerdt; Jeroen Hostens; Hans-Pietro Eugster; Walter Fiers; Peter Brouckaert
Bioavailability of recombinant tumor necrosis factor determines its lethality in mice.
European journal of immunology 2002;32(10):2759-65.
2002: Paul Ameloot; Walter Fiers; Wim A Buurman; Patrick De Baetselier; Peter Brouckaert
Characterization of the interaction between murine tumour necrosis factor and monoclonal antibodies.
Cytokine 2002;18(3):158-63.
2001: Walter Fiers; Sabine Neirynck; T Deroo; Xavier Saelens; Willy Min Jou
Soluble recombinant influenza vaccines.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2001;356(1416):1961-3.
2001: Gert De Wilde; Nico Mertens; Elke Boone; B De Vreese; J Van Beeumen; Walter Fiers; Guy Haegeman
Expression in Escherichia coli of the death domain of the human p55 tumor necrosis factor receptor.
Protein expression and purification 2001;23(2):226-32.
2001: Paul Ameloot; Walter Fiers; P De Bleser; Carl Ware; Peter Vandenabeele; Peter Brouckaert
Identification of tumor necrosis factor (TNF) amino acids crucial for binding to the murine p75 TNF receptor and construction of receptor-selective mutants.
The Journal of biological chemistry 2001;276(40):37426-30.
2001: Geertrui Denecker; Dominique Vercammen; M Steemans; Tom Vanden Berghe; Greet Brouckaert; Geert Van Loo; B Zhivotovsky; Walter Fiers; Johan Grooten; Wim Declercq; Peter Vandenabeele
Death receptor-induced apoptotic and necrotic cell death: differential role of caspases and mitochondria.
Cell death and differentiation 2001;8(8):829-40.
2001: Paul Ameloot; Wim Declercq; Walter Fiers; Peter Vandenabeele; Peter Brouckaert
Heterotrimers formed by tumor necrosis factors of different species or muteins.
The Journal of biological chemistry 2001;276(29):27098-103.
2000: R Schoonjans; An Willems; Steve Schoonooghe; Walter Fiers; Johan Grooten; Nico Mertens
Fab chains as an efficient heterodimerization scaffold for the production of recombinant bispecific and trispecific antibody derivatives.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(12):7050-7.
2000: Elke Boone; Tom Vanden Berghe; Geert Van Loo; Gert De Wilde; N De Wael; Dominique Vercammen; Walter Fiers; Guy Haegeman; Peter Vandenabeele
Structure/Function analysis of p55 tumor necrosis factor receptor and fas-associated death domain. Effect on necrosis in L929sA cells.
The Journal of biological chemistry 2000;275(48):37596-603.
2000: Katia Vancompernolle; Tom Boonefaes; M Mann; Walter Fiers; Johan Grooten
Tumor necrosis factor-induced microtubule stabilization mediated by hyperphosphorylated oncoprotein 18 promotes cell death.
The Journal of biological chemistry 2000;275(43):33876-82.
2000: Lothar Steidler; Wolfgang Hans; L Schotte; Sabine Neirynck; Florian Obermeier; Werner Falk; Walter Fiers; Erik Remaut
Treatment of murine colitis by Lactococcus lactis secreting interleukin-10.
Science (New York, N.Y.) 2000;289(5483):1352-5.
2000: Anje Cauwels; Wim Van Molle; Ben Janssen; B Everaerdt; P Huang; Walter Fiers; Peter Brouckaert
Protection against TNF-induced lethal shock by soluble guanylate cyclase inhibition requires functional inducible nitric oxide synthase.
Immunity 2000;13(2):223-31.
2000: Geertrui Denecker; H Dooms; Geert Van Loo; Dominique Vercammen; Johan Grooten; Walter Fiers; Wim Declercq; Peter Vandenabeele
Phosphatidyl serine exposure during apoptosis precedes release of cytochrome c and decrease in mitochondrial transmembrane potential.
FEBS letters 2000;465(1):47-52.
1999: Walter Fiers; Rudi Beyaert; W Declercq; Peter Vandenabeele
More than one way to die: apoptosis, necrosis and reactive oxygen damage.
Oncogene 1999;18(54):7719-30.
1999: M Van de Craen; Wim Declercq; I Van den Brande; Walter Fiers; Peter Vandenabeele
The proteolytic procaspase activation network: an in vitro analysis.
Cell death and differentiation 1999;6(11):1117-24.
1999: Sabine Neirynck; T Deroo; Xavier Saelens; Peter Vanlandschoot; Willy Min Jou; Walter Fiers
A universal influenza A vaccine based on the extracellular domain of the M2 protein.
Nature medicine 1999;5(10):1157-63.
1999: M Van de Craen; Geert Berx; I Van den Brande; Walter Fiers; Wim Declercq; Peter Vandenabeele
Proteolytic cleavage of beta-catenin by caspases: an in vitro analysis.
FEBS letters 1999;458(2):167-70.
1999: Claude Libert; Ben Wielockx; B Grijalba; Wim Van Molle; Elisabeth Kremmer; H R Colten; Walter Fiers; Peter Brouckaert
The role of complement activation in tumour necrosis factor-induced lethal hepatitis.
Cytokine 1999;11(8):617-25.
1999: D De Valck; D Y Jin; Karen Heyninck; M Van de Craen; R Contreras; Walter Fiers; K T Jeang; Rudi Beyaert
The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases.
Oncogene 1999;18(29):4182-90.
1999: Karen Heyninck; Geertrui Denecker; D De Valck; Walter Fiers; Rudi Beyaert
Inhibition of tumor necrosis factor-induced necrotic cell death by the zinc finger protein A20.
Anticancer research 1999;19(4B):2863-8.
1999: Karen Heyninck; D De Valck; Wim Vanden Berghe; Wim van Criekinge; R Contreras; Walter Fiers; Guy Haegeman; Rudi Beyaert
The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN.
The Journal of cell biology 1999;145(7):1471-82.
1999: Wim van Criekinge; Sigrid Cornelis; M Van de Craen; Peter Vandenabeele; Walter Fiers; Rudi Beyaert
GAL4 is a substrate for caspases: implications for two-hybrid screening and other GAL4-based assays.
Molecular cell biology research communications : MCBRC 1999;1(2):158-61.
1999: M Van de Craen; Chris De Jonghe; I Van den Brande; Wim Declercq; Geert Van Gassen; Wim van Criekinge; I Vanderhoeven; Walter Fiers; Christine Van Broeckhoven; L Hendriks; Peter Vandenabeele
Identification of caspases that cleave presenilin-1 and presenilin-2. Five presenilin-1 (PS1) mutations do not alter the sensitivity of PS1 to caspases.
FEBS letters 1999;445(1):149-54.
1999: Xavier Saelens; Peter Vanlandschoot; W Martinet; Marleen Maras; Sabine Neirynck; Roland Contreras; Walter Fiers; Willy Min Jou
Protection of mice against a lethal influenza virus challenge after immunization with yeast-derived secreted influenza virus hemagglutinin.
European journal of biochemistry / FEBS 1999;260(1):166-75.
1999: Claude Libert; Ben Wielockx; G L Hammond; Peter Brouckaert; Walter Fiers; R W Elliott
Identification of a locus on distal mouse chromosome 12 that controls resistance to tumor necrosis factor-induced lethal shock.
Genomics 1999;55(3):284-9.
1999: Maikel Peppelenbosch; Elke Boone; G E Jones; S J van Deventer; Guy Haegeman; Walter Fiers; Johan Grooten; Anne J Ridley
Multiple signal transduction pathways regulate TNF-induced actin reorganization in macrophages: inhibition of Cdc42-mediated filopodium formation by TNF.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(2):837-45.
1999: Vera Goossens; K De Vos; Dominique Vercammen; M Steemans; Katia Vancompernolle; Walter Fiers; Peter Vandenabeele; Johan Grooten
Redox regulation of TNF signaling.
BioFactors (Oxford, England) 1999;10(2-3):145-56.
1998: E Decoster; Sigrid Cornelis; B Vanhaesebroeck; Walter Fiers
Autocrine tumor necrosis factor (TNF) and lymphotoxin (LT) alpha differentially modulate cellular sensitivity to TNF/LT-alpha cytotoxicity in L929 cells.
The Journal of cell biology 1998;143(7):2057-65.
1998: M Van de Craen; Geert Van Loo; Wim Declercq; Peter Schotte; I Van den Brande; S Mandruzzato; Pierre van der Bruggen; Walter Fiers; Peter Vandenabeele
Molecular cloning and identification of murine caspase-8.
Journal of molecular biology 1998;284(4):1017-26.
1998: D De Valck; Dominique Vercammen; Walter Fiers; Rudi Beyaert
Differential activation of phospholipases during necrosis or apoptosis: a comparative study using tumor necrosis factor and anti-Fas antibodies.
Journal of cellular biochemistry 1998;71(3):392-9.
1998: Pieter Rottiers; T Verfaillie; R Contreras; Hilde Revets; M Desmedt; H Dooms; Walter Fiers; Johan Grooten
Differentiation of EL4 lymphoma cells by tumoral environment is associated with inappropriate expression of the large chondroitin sulfate proteoglycan PG-M and the tumor-associated antigen HTgp-175.
International journal of cancer. Journal international du cancer 1998;78(4):503-10.
1998: Katia Vancompernolle; Franky Van Herreweghe; Gwenda Pynaert; M Van de Craen; K De Vos; Nick Totty; A Sterling; Walter Fiers; Peter Vandenabeele; Johan Grooten
Atractyloside-induced release of cathepsin B, a protease with caspase-processing activity.
FEBS letters 1998;438(3):150-8.
1998: Claude Libert; Tino Hochepied; Franklin G Berger; Heinz Baumann; Walter Fiers; Peter Brouckaert
High-level constitutive expression of alpha 1-acid glycoprotein and lack of protection against tumor necrosis factor-induced lethal shock in transgenic mice.
Transgenic research 1998;7(6):429-35.
1998: Peter Schotte; Wim van Criekinge; M Van de Craen; Geert Van Loo; M Desmedt; Johan Grooten; M Cornelissen; Leo De Ridder; Joël Vandekerckhove; Walter Fiers; Peter Vandenabeele; Rudi Beyaert
Cathepsin B-mediated activation of the proinflammatory caspase-11.
Biochemical and biophysical research communications 1998;251(1):379-87.
1998: M Van de Craen; Geert Van Loo; Stefan Pype; Wim van Criekinge; I Van den Brande; F Molemans; Walter Fiers; Wim Declercq; Peter Vandenabeele
Identification of a new caspase homologue: caspase-14.
Cell death and differentiation 1998;5(10):838-46.
1998: Wim van Criekinge; Maria van Gurp; E Decoster; Peter Schotte; M Van de Craen; Walter Fiers; Peter Vandenabeele; Rudi Beyaert
Use of the yeast three-hybrid system as a tool to study caspases.
Analytical biochemistry 1998;263(1):62-6.
1998: Dominique Vercammen; Greet Brouckaert; Geertrui Denecker; M Van de Craen; Wim Declercq; Walter Fiers; Peter Vandenabeele
Dual signaling of the Fas receptor: initiation of both apoptotic and necrotic cell death pathways.
The Journal of experimental medicine 1998;188(5):919-30.
1998: H Dooms; M Desmedt; S Vancaeneghem; Pieter Rottiers; Vera Goossens; Walter Fiers; Johan Grooten
Quiescence-inducing and antiapoptotic activities of IL-15 enhance secondary CD4+ T cell responsiveness to antigen.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(5):2141-50.
1998: Peter Vanlandschoot; Els Beirnaert; B Barrère; Lesley J Calder; B Millar; Steve A Wharton; Willy Min Jou; Walter Fiers
An antibody which binds to the membrane-proximal end of influenza virus haemagglutinin (H3 subtype) inhibits the low-pH-induced conformational change and cell-cell fusion but does not neutralize virus.
The Journal of general virology 1998;79 ( Pt 7)():1781-91.
1998: Wim Declercq; Geertrui Denecker; Walter Fiers; Peter Vandenabeele
Cooperation of both TNF receptors in inducing apoptosis: involvement of the TNF receptor-associated factor binding domain of the TNF receptor 75.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(1):390-9.
1998: M Desmedt; Pieter Rottiers; H Dooms; Walter Fiers; Johan Grooten
Macrophages induce cellular immunity by activating Th1 cell responses and suppressing Th2 cell responses.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(11):5300-8.
1998: Dominique Vercammen; Rudi Beyaert; Geertrui Denecker; Vera Goossens; Geert Van Loo; Wim Declercq; Johan Grooten; Walter Fiers; Peter Vandenabeele
Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor.
The Journal of experimental medicine 1998;187(9):1477-85.
1998: K De Vos; Vera Goossens; Elke Boone; Dominique Vercammen; Katia Vancompernolle; Peter Vandenabeele; Guy Haegeman; Walter Fiers; Johan Grooten
The 55-kDa tumor necrosis factor receptor induces clustering of mitochondria through its membrane-proximal region.
The Journal of biological chemistry 1998;273(16):9673-80.
1998: Isabelle Carpentier; Wim Declercq; NL Malinin; David Wallach; Walter Fiers; Rudi Beyaert
TRAF2 plays a dual role in NF-kappaB-dependent gene activation by mediating the TNF-induced activation of p38 MAPK and IkappaB kinase pathways.
FEBS letters 1998;425(2):195-8.
1998: Wim Vanden Berghe; Stephane Plaisance; Elke Boone; Karolien De Bosscher; M Lienhard Schmitz; Walter Fiers; Guy Haegeman
p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways are required for nuclear factor-kappaB p65 transactivation mediated by tumor necrosis factor.
The Journal of biological chemistry 1998;273(6):3285-90.
1998: E Decoster; B Vanhaesebroeck; Elke Boone; Stephane Plaisance; K De Vos; Guy Haegeman; Johan Grooten; Walter Fiers
Induction of unresponsiveness to tumor necrosis factor (TNF) after autocrine TNF expression requires TNF membrane retention.
The Journal of biological chemistry 1998;273(6):3271-7.
1998: W Martinet; T Deroo; Xavier Saelens; Els Beirnaert; Peter Vanlandschoot; Roland Contreras; Walter Fiers; Willy Min Jou
Evaluation of recombinant A/Victoria/3/75 (H3N2) influenza neuraminidase mutants as potential broad-spectrum subunit vaccines against influenza A.
Archives of virology 1998;143(10):2011-9.
1998: Peter Vanlandschoot; Els Beirnaert; Johan Grooten; Willy Min Jou; Walter Fiers
pH-dependent aggregation and secretion of soluble monomeric influenza hemagglutinin.
Archives of virology 1998;143(2):227-39.
1998: Lothar Steidler; J Viaene; Walter Fiers; Erik Remaut
Functional display of a heterologous protein on the surface of Lactococcus lactis by means of the cell wall anchor of Staphylococcus aureus protein A.
Applied and environmental microbiology 1998;64(1):342-5.
1997: Karolien De Bosscher; M Lienhard Schmitz; Wim Vanden Berghe; Stephane Plaisance; Walter Fiers; Guy Haegeman
Glucocorticoid-mediated repression of nuclear factor-kappaB-dependent transcription involves direct interference with transactivation.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(25):13504-9.
1997: Marleen Maras; Xavier Saelens; Wouter Laroy; Kathleen Piens; Marc Claeyssens; Walter Fiers; Roland Contreras
In vitro conversion of the carbohydrate moiety of fungal glycoproteins to mammalian-type oligosaccharides--evidence for N-acetylglucosaminyltransferase-I-accepting glycans from Trichoderma reesei.
European journal of biochemistry / FEBS 1997;249(3):701-7.
1997: Dominique Vercammen; Peter Vandenabeele; Rudi Beyaert; Wim Declercq; Walter Fiers
Tumour necrosis factor-induced necrosis versus anti-Fas-induced apoptosis in L929 cells.
Cytokine 1997;9(11):801-8.
1997: E Decoster; V Vandevoorde; Rudi Beyaert; Guy Haegeman; Walter Fiers
Resistance to tumor necrosis factor (TNF) cytotoxicity by autocrine TNF production is independent of intracellular signaling pathways.
FEBS letters 1997;416(2):183-6.
1997: Wim Van Molle; Claude Libert; Walter Fiers; Peter Brouckaert
Alpha 1-acid glycoprotein and alpha 1-antitrypsin inhibit TNF-induced but not anti-Fas-induced apoptosis of hepatocytes in mice.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(7):3555-64.
1997: D De Valck; Karen Heyninck; Wim van Criekinge; Peter Vandenabeele; Walter Fiers; Rudi Beyaert
A20 inhibits NF-kappaB activation independently of binding to 14-3-3 proteins.
Biochemical and biophysical research communications 1997;238(2):590-4.
1997: Geertrui Denecker; Peter Vandenabeele; Johan Grooten; Louis C Penning; Wim Declercq; Rudi Beyaert; W A Buurman; Walter Fiers
Differential role of calcium in tumour necrosis factor-mediated apoptosis and secretion of granulocyte-macrophage colony-stimulating factor in a T cell hybridoma.
Cytokine 1997;9(9):631-8.
1997: W Martinet; Xavier Saelens; T Deroo; Sabine Neirynck; Roland Contreras; Willy Min Jou; Walter Fiers
Protection of mice against a lethal influenza challenge by immunization with yeast-derived recombinant influenza neuraminidase.
European journal of biochemistry / FEBS 1997;247(1):332-8.
1997: Rudolf Lucas; P Juillard; E Decoster; Mireille Redard; D Burger; Yves Donati; Christian Giroud; Christine Monso-Hinard; T De Kesel; WA Buurman; M W Moore; Jean-Michel Dayer; Walter Fiers; H Bluethmann; Georges E Grau
Crucial role of tumor necrosis factor (TNF) receptor 2 and membrane-bound TNF in experimental cerebral malaria.
European journal of immunology 1997;27(7):1719-25.
1997: Stephane Plaisance; Wim Vanden Berghe; Elke Boone; Walter Fiers; Guy Haegeman
Recombination signal sequence binding protein Jkappa is constitutively bound to the NF-kappaB site of the interleukin-6 promoter and acts as a negative regulatory factor.
Molecular and cellular biology 1997;17(7):3733-43.
1997: V Vandevoorde; Guy Haegeman; Walter Fiers
Induced expression of trimerized intracellular domains of the human tumor necrosis factor (TNF) p55 receptor elicits TNF effects.
The Journal of cell biology 1997;137(7):1627-38.
1997: Wouter Laroy; Marleen Maras; Walter Fiers; Roland Contreras
A radioactive assay for sialyltransferase activity using 96-well multiscreen filtration plates.
Analytical biochemistry 1997;249(1):108-11.
1997: R M Barge; R Willemze; Peter Vandenabeele; Walter Fiers; Rudi Beyaert
Differential involvement of caspases in apoptosis of myeloid leukemic cells induced by chemotherapy versus growth factor withdrawal.
FEBS letters 1997;409(2):207-10.
1997: Rudi Beyaert; Vincent J Kidd; Sigrid Cornelis; M Van de Craen; Geertrui Denecker; Jill Lahti; R Gururajan; Peter Vandenabeele; Walter Fiers
Cleavage of PITSLRE kinases by ICE/CASP-1 and CPP32/CASP-3 during apoptosis induced by tumor necrosis factor.
The Journal of biological chemistry 1997;272(18):11694-7.
1997: Marleen Maras; A De Bruyn; J Schraml; Piet Herdewijn; Marc Claeyssens; Walter Fiers; Roland Contreras
Structural characterization of N-linked oligosaccharides from cellobiohydrolase I secreted by the filamentous fungus Trichoderma reesei RUTC 30.
European journal of biochemistry / FEBS 1997;245(3):617-25.
1997: M Van de Craen; I Van den Brande; Wim Declercq; M Irmler; Rudi Beyaert; J Tschopp; Walter Fiers; Peter Vandenabeele
Cleavage of caspase family members by granzyme B: a comparative study in vitro.
European journal of immunology 1997;27(5):1296-9.
1997: M Van de Craen; Peter Vandenabeele; Wim Declercq; I Van den Brande; Geert Van Loo; F Molemans; Peter Schotte; Wim van Criekinge; Rudi Beyaert; Walter Fiers
Characterization of seven murine caspase family members.
FEBS letters 1997;403(1):61-9.
1996: N Mertens; Erik Remaut; Walter Fiers
Increased stability of phage T7g10 mRNA is mediated by either a 5'- or a 3'-terminal stem-loop structure.
Biological chemistry 1996;377(12):811-7.
1996: Claude Libert; Wim Van Molle; Peter Brouckaert; Walter Fiers
alpha1-Antitrypsin inhibits the lethal response to TNF in mice.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(11):5126-9.
1996: Wim van Criekinge; Rudi Beyaert; M Van de Craen; Peter Vandenabeele; Peter Schotte; D De Valck; Walter Fiers
Functional characterization of the prodomain of interleukin-1beta-converting enzyme.
The Journal of biological chemistry 1996;271(44):27245-8.
1996: Volker Hack; A Gross; Ralf Kinscherf; M Bockstette; Walter Fiers; G Berke; Wulf Dröge
Abnormal glutathione and sulfate levels after interleukin 6 treatment and in tumor-induced cachexia.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1996;10(10):1219-26.
1996: Lothar Steidler; W Yu; Walter Fiers; Erik Remaut
The expression of the Photinus pyralis luciferase gene in Staphylococcus aureus Cowan I allows the development of a live amplifiable tool for immunodetection.
Applied and environmental microbiology 1996;62(7):2356-9.
1996: A Cauwels; Walter Fiers; Peter Brouckaert
Murine IL-12 is involved in Calmette-Guérin bacillus-induced sensitization and is by itself sufficient to sensitize mice to the lethal effects of human TNF1.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(12):4686-90.
1996: Rudi Beyaert; A Cuenda; Wim Vanden Berghe; Stephane Plaisance; J C Lee; Guy Haegeman; P Cohen; Walter Fiers
The p38/RK mitogen-activated protein kinase pathway regulates interleukin-6 synthesis response to tumor necrosis factor.
The EMBO journal 1996;15(8):1914-23.
1996: D De Valck; Karen Heyninck; Wim van Criekinge; Roland Contreras; Rudi Beyaert; Walter Fiers
A20, an inhibitor of cell death, self-associates by its zinc finger domain.
FEBS letters 1996;384(1):61-4.
1996: T Deroo; Willy Min Jou; Walter Fiers
Recombinant neuraminidase vaccine protects against lethal influenza.
Vaccine 1996;14(6):561-9.
1996: Vera Goossens; Johan Grooten; Walter Fiers
The oxidative metabolism of glutamine. A modulator of reactive oxygen intermediate-mediated cytotoxicity of tumor necrosis factor in L929 fibrosarcoma cells.
The Journal of biological chemistry 1996;271(1):192-6.
1996: Peter Vanlandschoot; Els Beirnaert; Sabine Neirynck; Xavier Saelens; Willy Min Jou; Walter Fiers
Molecular and immunological characterization of soluble aggregated A/Victoria/3/75 (H3N2) influenza haemagglutinin expressed in insect cells.
Archives of virology 1996;141(9):1715-26.
1995: N Takahashi; Walter Fiers; Peter Brouckaert
Anti-tumor activity of tumor necrosis factor in combination with interferon-gamma is not affected by prior tolerization.
International journal of cancer. Journal international du cancer 1995;63(6):846-54.
1995: N Mertens; Erik Remaut; Walter Fiers
Versatile, multi-featured plasmids for high-level expression of heterologous genes in Escherichia coli: overproduction of human and murine cytokines.
Gene 1995;164(1):9-15.
1995: Rudi Beyaert; B Vanhaesebroeck; Wim Declercq; Johan Van Lint; P Vandenabele; Patrizia Agostinis; Jackie R Vandenheede; Walter Fiers
Casein kinase-1 phosphorylates the p75 tumor necrosis factor receptor and negatively regulates tumor necrosis factor signaling for apoptosis.
The Journal of biological chemistry 1995;270(40):23293-9.
1995: Wim Declercq; Peter Vandenabeele; Walter Fiers
Dimerization of chimeric erythropoietin/75 kDa tumour necrosis factor (TNF) receptors transduces TNF signals: necessity for the 75 kDa-TNF receptor transmembrane domain.
Cytokine 1995;7(7):701-9.
1995: Peter Vanlandschoot; Els Beirnaert; S Dewilde; Xavier Saelens; T Bestebroer; J De Jong; Willy Min Jou; Walter Fiers
A fairly conserved epitope on the hemagglutinin of influenza A (H3N2) virus with variable accessibility to neutralizing antibody.
Virology 1995;212(2):526-34.
1995: Daisy Flamez; Erik Remaut; Walter Fiers
Production in Escherichia coli of a functional murine and murine::human chimeric F(ab')2 fragment and mature antibody directed against human placental alkaline phosphatase.
Journal of biotechnology 1995;42(2):133-43.
1995: Vera Goossens; Johan Grooten; K De Vos; Walter Fiers
Direct evidence for tumor necrosis factor-induced mitochondrial reactive oxygen intermediates and their involvement in cytotoxicity.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(18):8115-9.
1995: E Decoster; B Vanhaesebroeck; Peter Vandenabeele; Johan Grooten; Walter Fiers
Generation and biological characterization of membrane-bound, uncleavable murine tumor necrosis factor.
The Journal of biological chemistry 1995;270(31):18473-8.
1995: J Robbens; A Raeymaekers; Lothar Steidler; Walter Fiers; Erik Remaut
Production of soluble and active recombinant murine interleukin-2 in Escherichia coli: high level expression, Kil-induced release, and purification.
Protein expression and purification 1995;6(4):481-6.
1995: N Takahashi; Peter Brouckaert; Walter Fiers
Mechanism of tolerance to tumor necrosis factor: receptor-specific pathway and selectivity.
The American journal of physiology 1995;269(2 Pt 2):R398-405.
1995: Dominique Vercammen; Peter Vandenabeele; Wim Declercq; M Van de Craen; Johan Grooten; Walter Fiers
Cytotoxicity in L929 murine fibrosarcoma cells after triggering of transfected human p75 tumour necrosis factor (TNF) receptor is mediated by endogenous murine TNF.
Cytokine 1995;7(5):463-70.
1995: Marek Los; M Van de Craen; Louis C Penning; H Schenk; M Westendorp; PA Baeuerle; Wulf Dröge; Peter H Krammer; Walter Fiers; Klaus Schulze-Osthoff
Requirement of an ICE/CED-3 protease for Fas/APO-1-mediated apoptosis.
Nature 1995;375(6526):81-3.
1995: Lothar Steidler; Jerry M Wells; A Raeymaekers; J Vandekerckhove; Walter Fiers; Erik Remaut
Secretion of biologically active murine interleukin-2 by Lactococcus lactis subsp. lactis.
Applied and environmental microbiology 1995;61(4):1627-9.
1995: Peter Vandenabeele; Wim Declercq; B Vanhaesebroeck; Johan Grooten; Walter Fiers
Both TNF receptors are required for TNF-mediated induction of apoptosis in PC60 cells.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(6):2904-13.
1995: A Cauwels; Peter Brouckaert; Johan Grooten; S Huang; M Aguet; Walter Fiers
Involvement of IFN-gamma in Bacillus Calmette-Guérin-induced but not in tumor-induced sensitization to TNF-induced lethality.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(6):2753-63.
1995: N Mertens; Erik Remaut; Walter Fiers
Tight transcriptional control mechanism ensures stable high-level expression from T7 promoter-based expression plasmids.
Bio/technology (Nature Publishing Company) 1995;13(2):175-9.
1995: Walter Fiers; Rudi Beyaert; Elke Boone; Sigrid Cornelis; Wim Declercq; E Decoster; Geertrui Denecker; B Depuydt; D De Valck; G De Wilde; Vera Goossens; Johan Grooten; Guy Haegeman; Karen Heyninck; Louis C Penning; Stephane Plaisance; Katia Vancompernolle; Wim van Criekinge; Peter Vandenabeele; Wim Vanden Berghe; M Van de Craen; V Vandevoorde; Dominique Vercammen
TNF-induced intracellular signaling leading to gene induction or to cytotoxicity by necrosis or by apoptosis.
Journal of inflammation 1995;47(1-2):67-75.
1995: Peter Brouckaert; Claude Libert; A Cauwels; B Everaerdt; Wim Van Molle; P Ameloot; Y Gansemans; B Grijalba; N Takahashi; M J Truong; P Van Leuven; Walter Fiers
Inhibition of and sensitization to the lethal effects of tumor necrosis factor.
Journal of inflammation 1995;47(1-2):18-26.
1995: Claude Libert; Wim Van Molle; Peter Brouckaert; Walter Fiers
Platelet-activating factor is a mediator in tumor necrosis factor/galactosamine-induced lethality.
Journal of inflammation 1995;46(3):139-43.
1994: Claude Libert; Peter Brouckaert; Walter Fiers
Protection by alpha 1-acid glycoprotein against tumor necrosis factor-induced lethality.
The Journal of experimental medicine 1994;180(4):1571-5.
1994: Claude Libert; N Takahashi; A Cauwels; Peter Brouckaert; H Bluethmann; Walter Fiers
Response of interleukin-6-deficient mice to tumor necrosis factor-induced metabolic changes and lethality.
European journal of immunology 1994;24(9):2237-42.
1994: M Logghe; F Molemans; Walter Fiers; Roland Contreras
The two genes encoding yeast ribosomal protein S8 reside on different chromosomes, and are closely linked to the hsp70 stress protein genes SSA3 and SSA4.
Yeast (Chichester, England) 1994;10(8):1093-1100.
1994: Peter Brouckaert; P Ameloot; A Cauwels; B Everaerdt; Claude Libert; N Takahashi; Wim Van Molle; Walter Fiers
Receptor-selective mutants of tumour necrosis factor in the therapy of cancer: preclinical studies.
Circulatory shock 1994;43(4):185-90.
1994: B Everaerdt; Peter Brouckaert; Walter Fiers
Recombinant IL-1 receptor antagonist protects against TNF-induced lethality in mice.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(10):5041-9.
1994: N Takahashi; Peter Brouckaert; M H Bemelmans; W A Buurman; Walter Fiers
Mechanism of induction of tolerance to tumour necrosis factor (TNF): no involvement of modulators of TNF bioavailability or receptor binding.
Cytokine 1994;6(3):235-42.
1994: Peter Vanhoenacker; Walter Fiers; Guy Haegeman
Studies on the induction of the interleukin-6 promoter in cell lines of human and simian origin.
European cytokine network 1994;5(3):283-91.
1994: K De Sutter; K Hostens; J Vandekerckhove; Walter Fiers
Production of enzymatically active rat protein disulfide isomerase in Escherichia coli.
Gene 1994;141(2):163-70.
1994: X Van Ostade; Peter Vandenabeele; Jan Tavernier; Walter Fiers
Human tumor necrosis factor mutants with preferential binding to and activity on either the R55 or R75 receptor.
European journal of biochemistry / FEBS 1994;220(3):771-9.
1994: K De Sutter; Walter Fiers
A bifunctional murine::human chimeric antibody with one antigen-binding arm replaced by bacterial beta-lactamase.
Molecular immunology 1994;31(4):261-7.
1994: Rudi Beyaert; Walter Fiers
Molecular mechanisms of tumor necrosis factor-induced cytotoxicity. What we do understand and what we do not.
FEBS letters 1994;340(1-2):9-16.
1994: J A Barbara; W B Smith; Jennifer R Gamble; X Van Ostade; P Vandenabeele; Jan Tavernier; Walter Fiers; Mathew A Vadas; Angel F Lopez
Dissociation of TNF-alpha cytotoxic and proinflammatory activities by p55 receptor- and p75 receptor-selective TNF-alpha mutants.
The EMBO journal 1994;13(4):843-50.
1994: J Demolder; Walter Fiers; Roland Contreras
Human interferon-beta, expressed in Saccharomyces cerevisiae, is predominantly directed to the vacuoles. Influence of modified co-expression of secretion factors and chaperones.
Journal of biotechnology 1994;32(2):179-89.
1994: X Van Ostade; Jan Tavernier; Walter Fiers
Structure-activity studies of human tumour necrosis factors.
Protein engineering 1994;7(1):5-22.
1993: Lothar Steidler; Erik Remaut; Walter Fiers
Pap pili as a vector system for surface exposition of an immunoglobulin G-binding domain of protein A of Staphylococcus aureus in Escherichia coli.
Journal of bacteriology 1993;175(23):7639-43.
1993: Johan Grooten; Vera Goossens; B Vanhaesebroeck; Walter Fiers
Cell membrane permeabilization and cellular collapse, followed by loss of dehydrogenase activity: early events in tumour necrosis factor-induced cytotoxicity.
Cytokine 1993;5(6):546-55.
1993: Peter Vanlandschoot; Geert Maertens; Willy Min Jou; Walter Fiers
Recombinant secreted haemagglutinin protects mice against a lethal challenge of influenza virus.
Vaccine 1993;11(12):1185-7.
1993: K Schulze-Osthoff; Rudi Beyaert; V Vandevoorde; Guy Haegeman; Walter Fiers
Depletion of the mitochondrial electron transport abrogates the cytotoxic and gene-inductive effects of TNF.
The EMBO journal 1993;12(8):3095-104.
1993: Rudi Beyaert; Karen Heyninck; D De Valck; F Boeykens; Frans van Roy; Walter Fiers
Enhancement of tumor necrosis factor cytotoxicity by lithium chloride is associated with increased inositol phosphate accumulation.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(1):291-300.
1993: Rudi Beyaert; B Vanhaesebroeck; Karen Heyninck; Elke Boone; D De Valck; K Schulze-Osthoff; Guy Haegeman; Frans van Roy; Walter Fiers
Sensitization of tumor cells to tumor necrosis factor action by the protein kinase inhibitor staurosporine.
Cancer research 1993;53(11):2623-30.
1993: Y Guisez; J Demolder; N Mertens; A Raeymaekers; G Plaetinck; J Robbens; Joël Vandekerckhove; Erik Remaut; Walter Fiers
High-level expression, purification, and renaturation of recombinant murine interleukin-2 from Escherichia coli.
Protein expression and purification 1993;4(3):240-6.
1993: Y Guisez; J Robbens; Erik Remaut; Walter Fiers
Folding of the MS2 coat protein in Escherichia coli is modulated by translational pauses resulting from mRNA secondary structure and codon usage: a hypothesis.
Journal of theoretical biology 1993;162(2):243-52.
1993: Peter Vandenabeele; Daniel Abramowicz; D Berus; J Van der Heyden; Johan Grooten; Vincent Donckier; E L Hooghe-Peters; M Goldman; Walter Fiers
Increased IL-6 production and IL-6-mediated Ig secretion in murine host-vs-graft disease.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(9):4179-87.
1993: B Vanhaesebroeck; J C Reed; D De Valck; Johan Grooten; T Miyashita; S Tanaka; Rudi Beyaert; Frans van Roy; Walter Fiers
Effect of bcl-2 proto-oncogene expression on cellular sensitivity to tumor necrosis factor-mediated cytotoxicity.
Oncogene 1993;8(4):1075-81.
1993: Peter Brouckaert; Claude Libert; B Everaerdt; N Takahashi; A Cauwels; Walter Fiers
Tumor necrosis factor, its receptors and the connection with interleukin 1 and interleukin 6.
Immunobiology 1993;187(3-5):317-29.
1993: D De Valck; Rudi Beyaert; Frans van Roy; Walter Fiers
Tumor necrosis factor cytotoxicity is associated with phospholipase D activation.
European journal of biochemistry / FEBS 1993;212(2):491-7.
1993: J Demolder; Marianne D De Backer; Walter Fiers; Roland Contreras
Phenotypic effects in Saccharomyces cerevisiae after regulated expression of beta-(1,3)-glucanase from Nicotiana plumbaginifolia.
Journal of biotechnology 1993;27(3):295-305.
1993: X Van Ostade; Peter Vandenabeele; B Everaerdt; Hansruedi Loetscher; R Gentz; M Brockhaus; W Lesslauer; Jan Tavernier; Peter Brouckaert; Walter Fiers
Human TNF mutants with selective activity on the p55 receptor.
Nature 1993;361(6409):266-9.
1993: Lothar Steidler; Erik Remaut; Walter Fiers
LamB as a carrier molecule for the functional exposition of IgG-binding domains of the Staphylococcus aureus protein A at the surface of Escherichia coli K12.
Molecular & general genetics : MGG 1993;236(2-3):187-92.
1993: N P Patestos; Guy Haegeman; V Vandevoorde; Walter Fiers
Activation of the nuclear factor kappa B is not sufficient for regulation of tumor necrosis factor-induced interleukin-6 gene expression.
Biochimie 1993;75(11):1007-18.
1992: Johan Van Lint; Patrizia Agostinis; V Vandevoorde; Guy Haegeman; Walter Fiers; Wilfried Merlevede; Jackie R Vandenheede
Tumor necrosis factor stimulates multiple serine/threonine protein kinases in Swiss 3T3 and L929 cells. Implication of casein kinase-2 and extracellular signal-regulated kinases in the tumor necrosis factor signal transduction pathway.
The Journal of biological chemistry 1992;267(36):25916-21.
1992: Peter Vandenabeele; Wim Declercq; Dominique Vercammen; M Van de Craen; Johan Grooten; Hansruedi Loetscher; M Brockhaus; W Lesslauer; Walter Fiers
Functional characterization of the human tumor necrosis factor receptor p75 in a transfected rat/mouse T cell hybridoma.
The Journal of experimental medicine 1992;176(4):1015-24.
1992: Claude Libert; Anne Vink; Pierre G Coulie; Peter Brouckaert; B Everaerdt; J Van Snick; Walter Fiers
Limited involvement of interleukin-6 in the pathogenesis of lethal septic shock as revealed by the effect of monoclonal antibodies against interleukin-6 or its receptor in various murine models.
European journal of immunology 1992;22(10):2625-30.
1992: Peter Brouckaert; Claude Libert; B Everaerdt; Walter Fiers
Selective species specificity of tumor necrosis factor for toxicity in the mouse.
Lymphokine and cytokine research 1992;11(4):193-6.
1992: K De Sutter; Erik Remaut; Walter Fiers
Disulphide bridge formation in the periplasm of Escherichia coli: beta-lactamase:: human IgG3 hinge fusions as a model system.
Molecular microbiology 1992;6(15):2201-8.
1992: Rudi Beyaert; K Schulze-Osthoff; Frans van Roy; Walter Fiers
Synergistic induction of interleukin-6 by tumor necrosis factor and lithium chloride in mice: possible role in the triggering and exacerbation of psoriasis by lithium treatment.
European journal of immunology 1992;22(8):2181-4.
1992: V Vandevoorde; Guy Haegeman; Walter Fiers
TNF-mediated IL6 gene expression and cytotoxicity are co-inducible in TNF-resistant L929 cells.
FEBS letters 1992;302(3):235-8.
1992: B Vanhaesebroeck; E Decoster; X Van Ostade; S Van Bladel; A Lenaerts; Frans van Roy; Walter Fiers
Expression of an exogenous tumor necrosis factor (TNF) gene in TNF-sensitive cell lines confers resistance to TNF-mediated cell lysis.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(9):2785-94.
1992: K De Sutter; V Feys; A Van de Voorde; Walter Fiers
Production of functionally active murine and murine::human chimeric F(ab')2 fragments in COS-1 cells.
Gene 1992;113(2):223-30.
1992: K Devos; F Duerinck; K Van Audenhove; Walter Fiers
Cloning and expression of the canine interferon-gamma gene.
Journal of interferon research 1992;12(2):95-102.
1992: Peter Brouckaert; B Everaerdt; Walter Fiers
The glucocorticoid antagonist RU38486 mimics interleukin-1 in its sensitization to the lethal and interleukin-6-inducing properties of tumor necrosis factor.
European journal of immunology 1992;22(4):981-6.
1992: K Schulze-Osthoff; A C Bakker; B Vanhaesebroeck; Rudi Beyaert; W A Jacob; Walter Fiers
Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation.
The Journal of biological chemistry 1992;267(8):5317-23.
1992: J Demolder; Walter Fiers; Roland Contreras
Efficient synthesis of secreted murine interleukin-2 by Saccharomyces cerevisiae: influence of 3'-untranslated regions and codon usage.
Gene 1992;111(2):207-13.
1992: N P Patestos; Guy Haegeman; Walter Fiers
TNF-induced, cytotoxicity-linked IL6 gene expression in L929 cells may require factors other than NF-kappa B.
Biochemical Society transactions 1992;20(1):80S.
1991: L Franco; A Jiménez; J Demolder; F Molemans; Walter Fiers; Roland Contreras
The nucleotide sequence of a third cyclophilin-homologous gene from Saccharomyces cerevisiae.
Yeast (Chichester, England) 1991;7(9):971-9.
1991: V Vandevoorde; Guy Haegeman; Walter Fiers
Tumor necrosis factor-induced interleukin-6 expression and cytotoxicity follow a common signal transduction pathway in L929 cells.
Biochemical and biophysical research communications 1991;178(3):993-1001.
1991: Claude Libert; S Van Bladel; Peter Brouckaert; Walter Fiers
The influence of modulating substances on tumor necrosis factor and interleukin-6 levels after injection of murine tumor necrosis factor or lipopolysaccharide in mice.
Journal of immunotherapy : official journal of the Society for Biological Therapy 1991;10(4):227-35.
1991: Walter Fiers
Tumor necrosis factor. Characterization at the molecular, cellular and in vivo level.
FEBS letters 1991;285(2):199-212.
1991: K Vleminckx; L Vakaet; Marc Mareel; Walter Fiers; Frans van Roy
Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role.
Cell 1991;66(1):107-19.
1991: P Vandenabeele; Walter Fiers
Is amyloidogenesis during Alzheimer's disease due to an IL-1-/IL-6-mediated 'acute phase response' in the brain?
Immunology today 1991;12(7):217-9.
1991: Rudi Beyaert; K Schulze-Osthoff; Frans van Roy; Walter Fiers
Lithium chloride potentiates tumor necrosis factor-induced and interleukin 1-induced cytokine and cytokine receptor expression.
Cytokine 1991;3(4):284-91.
1991: Y Guisez; B Tison; Joël Vandekerckhove; J Demolder; Guy Bauw; Guy Haegeman; Walter Fiers; Roland Contreras
Production and purification of recombinant human interleukin-6 secreted by the yeast Saccharomyces cerevisiae.
European journal of biochemistry / FEBS 1991;198(1):217-22.
1991: B Vanhaesebroeck; S Van Bladel; A Lenaerts; P Suffys; Rudi Beyaert; Rudolf Lucas; Frans van Roy; Walter Fiers
Two discrete types of tumor necrosis factor-resistant cells derived from the same cell line.
Cancer research 1991;51(9):2469-77.
1991: N Takahashi; Peter Brouckaert; Walter Fiers
Induction of tolerance allows separation of lethal and antitumor activities of tumor necrosis factor in mice.
Cancer research 1991;51(9):2366-72.
1991: B Vanhaesebroeck; Marc Mareel; Frans van Roy; Johan Grooten; Walter Fiers
Expression of the tumor necrosis factor gene in tumor cells correlates with reduced tumorigenicity and reduced invasiveness in vivo.
Cancer research 1991;51(8):2229-38.
1991: Claude Libert; S Van Bladel; Peter Brouckaert; A Shaw; Walter Fiers
Involvement of the liver, but not of IL-6, in IL-1-induced desensitization to the lethal effects of tumor necrosis factor.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(8):2625-32.
1991: Marc M Mareel; Jürgen Behrens; W Birchmeier; Georges de Bruyne; K Vleminckx; A Hoogewijs; Walter Fiers; Frans van Roy
Down-regulation of E-cadherin expression in Madin Darby canine kidney (MDCK) cells inside tumors of nude mice.
International journal of cancer. Journal international du cancer 1991;47(6):922-8.
1991: X Van Ostade; Jan Tavernier; T Prangé; Walter Fiers
Localization of the active site of human tumour necrosis factor (hTNF) by mutational analysis.
The EMBO journal 1991;10(4):827-36.
1991: Roland Contreras; D Carrez; James R Kinghorn; Cees A M J J van den Hondel; Walter Fiers
Efficient KEX2-like processing of a glucoamylase-interleukin-6 fusion protein by Aspergillus nidulans and secretion of mature interleukin-6.
Bio/technology (Nature Publishing Company) 1991;9(4):378-81.
1991: Rudi Beyaert; Christian R De Potter; B Vanhaesebroeck; Frans van Roy; Walter Fiers
Induction of inflammatory cell infiltration and necrosis in normal mouse skin by the combined treatment of tumor necrosis factor and lithium chloride.
The American journal of pathology 1991;138(3):727-39.
1991: S Van Bladel; Claude Libert; Walter Fiers
Interleukin-6 enhances the expression of tumor necrosis factor receptors on hepatoma cells and hepatocytes.
Cytokine 1991;3(2):149-54.
1991: P Suffys; Rudi Beyaert; D De Valck; B Vanhaesebroeck; Frans van Roy; Walter Fiers
Tumour-necrosis-factor-mediated cytotoxicity is correlated with phospholipase-A2 activity, but not with arachidonic acid release per se.
European journal of biochemistry / FEBS 1991;195(2):465-75.
1991: Walter Fiers
Molecular biology approaches to cancer and to cancer therapy.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 1991;122():1-8.
1990: Peter Vandenabeele; Wim Declercq; Claude Libert; Walter Fiers
Development of a simple, sensitive and specific bioassay for interleukin-1 based on the proliferation of RPMI 1788 cells. Comparison with other bioassays for IL-1.
Journal of immunological methods 1990;135(1-2):25-32.
1990: D Carrez; W Janssens; P Degrave; Cees A M J J van den Hondel; James R Kinghorn; Walter Fiers; Roland Contreras
Heterologous gene expression by filamentous fungi: secretion of human interleukin-6 by Aspergillus nidulans.
Gene 1990;94(2):147-54.
1990: Frans van Roy; Marc Mareel; K Vleminckx; Rudi Beyaert; Walter Fiers; N Devleeschouwer; C Muquardt; N Legros; Marc Bracke; G Leclercq
Hormone sensitivity in vitro and in vivo of v-ras-transfected MCF-7 cell derivatives.
International journal of cancer. Journal international du cancer 1990;46(3):522-32.
1990: B Vanhaesebroeck; H T Timmers; G J Pronk; Frans van Roy; Alex J van der Eb; Walter Fiers
Modulation of cellular susceptibility to the cytotoxic/cytostatic action of tumor necrosis factor by adenovirus E1 gene expression is cell type-dependent.
Virology 1990;176(2):362-8.
1990: Rudi Beyaert; P Suffys; Frans van Roy; Walter Fiers
Inhibition by glucocorticoids of tumor necrosis factor-mediated cytotoxicity. Evidence against lipocortin involvement.
FEBS letters 1990;262(1):93-6.
1990: Claude Libert; Peter Brouckaert; A Shaw; Walter Fiers
Induction of interleukin 6 by human and murine recombinant interleukin 1 in mice.
European journal of immunology 1990;20(3):691-4.
1990: B Vanhaesebroeck; E J Cragoe; J Pouysségur; Rudi Beyaert; Frans van Roy; Walter Fiers
Cytotoxic activity of tumor necrosis factor is inhibited by amiloride derivatives without involvement of the Na+/H+ antiporter.
FEBS letters 1990;261(2):319-22.
1990: Frans van Roy; G Liebaut; Marc Mareel; Walter Fiers
Partial transformation of human tumor cell lines showing defective interaction between unusual p53 gene product and SV40 large-T antigen.
Oncogene 1990;5(2):207-18.
1990: Peter Vandenabeele; Y Guisez; Wim Declercq; Guy Bauw; J Vandekerckhove; Walter Fiers
Response of murine cell lines to an IL-1/IL-2-induced factor in a rat/mouse T hybridoma (PC60): differential induction of cytokines by human IL-1 alpha and IL-1 beta and partial amino acid sequence of rat GM-CSF.
Lymphokine research 1990;9(3):381-9.
1990: Walter Fiers; Rudi Beyaert; Peter Brouckaert; B Everaerdt; Johan Grooten; A Lenaerts; Claude Libert; P Suffys; N Takahashi; Jan Tavernier
Tumour necrosis factor: mechanism of action at the molecular, cellular and in vivo level.
Scandinavian journal of clinical and laboratory investigation. Supplementum 1990;202():159.
1989: R Leemans; Erik Remaut; Walter Fiers
Correlation between temperature-dependent cytoplasmic solubility and periplasmic export of a heterologous protein in Escherichia coli.
Gene 1989;85(1):99-108.
1989: Rudi Beyaert; B Vanhaesebroeck; P Suffys; Frans van Roy; Walter Fiers
Lithium chloride potentiates tumor necrosis factor-mediated cytotoxicity in vitro and in vivo.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(23):9494-8.
1989: Frans van Roy; P Coopman; P Suffys; G Liebaut; K Vleminckx; J Gao; C H Dragonetti; Walter Fiers; Marc M Mareel
Effect of oncogene transfection or passage in vivo on malignant phenotypes of rat2 cells.
Anticancer research 1989;9(6):1553-64.
1989: B Everaerdt; Peter Brouckaert; A Shaw; Walter Fiers
Four different interleukin-1 species sensitize to the lethal action of tumour necrosis factor.
Biochemical and biophysical research communications 1989;163(1):378-85.
1989: B Vanhaesebroeck; Johan Grooten; Walter Fiers
An ongoing in vivo immune response affects the abundancy and differentiation of lymphokine-activated killer cell precursors, but does not influence their broad spectrum target reactivity.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(4):1396-402.
1989: B Jayaram; R Devos; Y Guisez; Walter Fiers
Purification of human interleukin-4 produced in Escherichia coli.
Gene 1989;79(2):345-54.
1989: Johan Grooten; Walter Fiers
Acquisition by the murine host of responsiveness toward various neoplastic cell lines, but not toward self, through adoptive transfer of a helper T-lymphocyte clone with antiself specificity.
Cancer research 1989;49(14):3872-8.
1989: Peter Brouckaert; David Spriggs; George D Demetri; Donald Kufe; Walter Fiers
Circulating interleukin 6 during a continuous infusion of tumor necrosis factor and interferon gamma.
The Journal of experimental medicine 1989;169(6):2257-62.
1989: Shiela E Unkles; E I Campbell; D Carrez; C Grieve; Roland Contreras; Walter Fiers; Cees A M J J van den Hondel; James R Kinghorn
Transformation of Aspergillus niger with the homologous nitrate reductase gene.
Gene 1989;78(1):157-66.
1989: Peter Brouckaert; Claude Libert; B Everaerdt; N Takahashi; Walter Fiers
A role for interleukin 1 in the in vivo actions of tumor necrosis factor.
Lymphokine research 1989;8(3):269-74.
1989: Walter Fiers; F R Balkwill
Future prospects and problems.
Cancer surveys 1989;8(4):921-7.
1989: Peter Brouckaert; B Everaerdt; Claude Libert; N Takahashi; Walter Fiers
Species specificity and involvement of other cytokines in endotoxic shock action of recombinant tumour necrosis factor in mice.
Agents and actions 1989;26(1-2):196-8.
1989: P Suffys; Rudi Beyaert; Frans van Roy; Walter Fiers
TNF in combination with interferon-gamma is cytotoxic to normal, untransformed mouse and rat embryo fibroblast-like cells.
Anticancer research 1989;9(1):167-71.
1988: P Suffys; Rudi Beyaert; Frans van Roy; Walter Fiers
Involvement of a serine protease in tumour-necrosis-factor-mediated cytotoxicity.
European journal of biochemistry / FEBS 1988;178(1):257-65.
1988: X Van Ostade; Jan Tavernier; Walter Fiers
Two conserved tryptophan residues of tumor necrosis factor and lymphotoxin are not involved in the biological activity.
FEBS letters 1988;238(2):347-52.
1988: Marc Mareel; C Dragonetti; J Tavernier; Walter Fiers
Tumor-selective cytotoxic effects of murine tumor necrosis factor (TNF) and interferon-gamma (IFN-gamma) in organ culture of B16 melanoma cells and heart tissue.
International journal of cancer. Journal international du cancer 1988;42(3):470-3.
1988: P De Waele; V Feys; A Van de Voorde; F Molemans; Walter Fiers
Expression in non-lymphoid cells of mouse recombinant immunoglobulin directed against the tumour marker human placental alkaline phosphatase.
European journal of biochemistry / FEBS 1988;176(2):287-95.
1988: Peter Vandenabeele; B Jayaram; R Devos; A Shaw; Walter Fiers
Interleukin 1 alpha acts as an autocrine growth factor for RPMI 1788, an Epstein-Barr virus-transformed human B cell line.
European journal of immunology 1988;18(7):1027-31.
1988: D Huylebroeck; Geert Maertens; M Verhoeyen; C Lopez; A Raeymakers; Willy Min Jou; Walter Fiers
High-level transient expression of influenza virus proteins from a series of SV40 late and early replacement vectors.
Gene 1988;66(2):163-81.
1988: P Suffys; Frans van Roy; Walter Fiers
Tumor necrosis factor and interleukin 1 activate phospholipase in rat chondrocytes.
FEBS letters 1988;232(1):24-8.
1988: Walter Fiers; Rudi Beyaert; Peter Brouckaert; B Everaerdt; C Haegeman; P Suffys; Jan Tavernier; B Vanhaesebroeck
TNF: its potential as an antitumour agent.
Developments in biological standardization 1988;69():143-51.
1988: V Feys; P De Waele; A Van de Voorde; P Casneuf; Walter Fiers
Expression of functional mouse antibodies directed against the tumour marker human placental alkaline phosphatase in non-lymphoid cells.
International journal of cancer. Supplement = Journal international du cancer. Supplement 1988;2():26-7.
1987: P Suffys; Rudi Beyaert; Frans van Roy; Walter Fiers
Reduced tumour necrosis factor-induced cytotoxicity by inhibitors of the arachidonic acid metabolism.
Biochemical and biophysical research communications 1987;149(2):735-43.
1987: Walter Fiers; Rudi Beyaert; Peter Brouckaert; B Everaerdt; Guy Haegeman; P Suffys; Jan Tavernier; Peter Vandenabeele; B Vanhaesebroeck; X Van Ostade
Gene cloning and structure--function relationship of cytokines such as TNF and interleukins.
Immunology letters 1987;16(3-4):219-26.
1987: G Plaetinck; Wim Declercq; Jan Tavernier; Markus Nabholz; Walter Fiers
Recombinant tumor necrosis factor can induce interleukin 2 receptor expression and cytolytic activity in a rat x mouse T cell hybrid.
European journal of immunology 1987;17(12):1835-8.
1987: Walter Fiers; Rudi Beyaert; Peter Brouckaert; B Everaert; P Suffys; Jan Tavernier; B Van Haesebroeck; Frans van Roy
Tumor necrosis factor: a potential antitumor agent?
Journal of interferon research 1987;7(5):627-34.
1987: J Gao; Frans van Roy; Ludwine MESSIAEN; J Cosaert; G Liebaut; P Coopman; Walter Fiers; Marc Mareel
Pathology of tumours produced in syngeneic Fischer rats by fibroblast-like cells before and after transfection with oncogenes.
Pathology, research and practice 1987;182(1):48-57.
1987: Walter Fiers; Peter Brouckaert; A L Goldberg; I Kettelhut; P Suffys; Jan Tavernier; B Vanhaesebroeck; Frans van Roy
Structure-function relationship of tumour necrosis factor and its mechanism of action.
Ciba Foundation symposium 1987;131():109-23.
1986: Frans van Roy; Ludwine MESSIAEN; G Liebaut; J Gao; C H Dragonetti; Walter Fiers; Marc M Mareel
Invasiveness and metastatic capability of rat fibroblast-like cells before and after transfection with immortalizing and transforming genes.
Cancer research 1986;46(9):4787-95.
1986: P Stanssens; Erik Remaut; Walter Fiers
Inefficient translation initiation causes premature transcription termination in the lacZ gene.
Cell 1986;44(5):711-8.
1986: Walter Fiers; Peter Brouckaert; R Devos; L Fransen; G Leroux-Roels; Erik Remaut; P Suffys; Jan Tavernier; J Van der Heyden; F Van Roy
Lymphokines and monokines in anti-cancer therapy.
Cold Spring Harbor symposia on quantitative biology 1986;51 Pt 1():587-95.
1986: Erik Remaut; P Stanssens; G Simons; Walter Fiers
Use of the phage lambda PL promoter for high-level expression of human interferons in Escherichia coli.
Methods in enzymology 1986;119():366-75.
1985: R Devos; B Jayaram; Peter Vandenabeele; Walter Fiers
Recombinant interleukin 2 induces immunoglobulin secretion in Staphylococcus aureus Cowan strain I activated human B-cells.
Immunology letters 1985;11(2):101-5.
1985: P Stanssens; Erik Remaut; Walter Fiers
Alterations upstream from the Shine-Dalgarno region and their effect on bacterial gene expression.
Gene 1985;36(3):211-23.
1983: M Verhoeyen; L Van Rompuy; Willy Min Jou; D Huylebroeck; Walter Fiers
Complete nucleotide sequence of the influenza B/Singapore/222/79 virus hemagglutinin gene and comparison with the B/Lee/40 hemagglutinin.
Nucleic acids research 1983;11(14):4703-12.
1983: Erik Remaut; P Stanssens; Walter Fiers
Inducible high level synthesis of mature human fibroblast interferon in Escherichia coli.
Nucleic acids research 1983;11(14):4677-88.
1983: R Devos; G Plaetinck; H Cheroutre; G Simons; Wim Degrave; Jan Tavernier; Erik Remaut; Walter Fiers
Molecular cloning of human interleukin 2 cDNA and its expression in E. coli.
Nucleic acids research 1983;11(13):4307-23.
1983: D Gheysen; A van de Voorde; R Contreras; J Vanderheyden; F Duerinck; Walter Fiers
Simian virus 40 mutants carrying extensive deletions in the 72-base-pair repeat region.
Journal of virology 1983;47(1):1-14.
1983: Jan Tavernier; D Gheysen; F Duerinck; J Van der Heyden; Walter Fiers
Deletion mapping of the inducible promoter of human IFN-beta gene.
Nature 1983;301(5901):634-6.
1983: Wim Degrave; Jan Tavernier; F Duerinck; G Plaetinck; R Devos; Walter Fiers
Cloning and structure of the human interleukin 2 chromosomal gene.
The EMBO journal 1983;2(12):2349-53.
1982: R Contreras; D Gheysen; J Knowland; A van de Voorde; Walter Fiers
Evidence for the direct involvement of DNA replication origin in synthesis of late SV40 RNA.
Nature 1982;300(5892):500-5.
1982: R Contreras; H Cheroutre; Wim Degrave; Walter Fiers
Simple, efficient in vitro synthesis of capped RNA useful for direct expression of cloned eukaryotic genes.
Nucleic acids research 1982;10(20):6353-62.
1982: L Van Rompuy; Willy Min Jou; D Huylebroeck; Walter Fiers
Complete nucleotide sequence of a human influenza neuraminidase gene of subtype N2 (A/Victoria/3/75).
Journal of molecular biology 1982;161(1):1-11.
1982: Walter Fiers; Erik Remaut; R Devos; H Cheroutre; R Contreras; D Gheysen; Wim Degrave; P Stanssens; Jan Tavernier; Y Taya; J Content
The human fibroblast and human immune interferon genes and their expression in homologous and heterologous cells.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1982;299(1094):29-38.
1982: R Devos; H Cheroutre; Y Taya; Wim Degrave; H Van Heuverswyn; Walter Fiers
Molecular cloning of human immune interferon cDNA and its expression in eukaryotic cells.
Nucleic acids research 1982;10(8):2487-501.
1982: Erik Remaut; P D Waele; A Marmenout; P Stanssens; Walter Fiers
Functional expression of individual plasmid-coded RNA bacteriophage MS2 genes.
The EMBO journal 1982;1(2):205-9.
1982: Walter Fiers; Wim Degrave; R Derynck; R Devos; D Gheysen; Erik Remaut; P Stanssens; Jan Tavernier; J Content; E De Clercq
The human fibroblast interferon gene(s) and their expression in heterologous cells.
Princess Takamatsu symposia 1982;12():227-36.
1982: Y Taya; R Devos; Jan Tavernier; H Cheroutre; G Engler; Walter Fiers
Cloning and structure of the human immune interferon-gamma chromosomal gene.
The EMBO journal 1982;1(8):953-8.
1982: R Devos; H Cheroutre; Y Taya; Walter Fiers
Isolation and characterization of IFN-gamma mRNA derived from mitogen-induced human splenocytes.
Journal of interferon research 1982;2(3):409-20.
1981: R Derynck; R Devos; Erik Remaut; E Saman; P Stanssens; Jan Tavernier; G Volckaert; J Content; E De Clercq; Walter Fiers
Isolation and characterization of a human fibroblast interferon gene and its expression in Escherichia coli.
Reviews of infectious diseases 1981;3(6):1186-95.
1981: Erik Remaut; P Stanssens; Walter Fiers
Plasmid vectors for high-efficiency expression controlled by the PL promoter of coliphage lambda.
Gene 1981;15(1):81-93.
1981: R Fang; W Min Jou; D Huylebroeck; R Devos; Walter Fiers
Complete structure of A/duck/Ukraine/63 influenza hemagglutinin gene: animal virus as progenitor of human H3 Hong Kong 1968 influenza hemagglutinin.
Cell 1981;25(2):315-23.
1981: L Van Rompuy; W Min Jou; D Huylebroeck; R Devos; Walter Fiers
Complete nucleotide sequence of the nucleoprotein gene from the human influenza strain A/PR/8/34 (HON1).
European journal of biochemistry / FEBS 1981;116(2):347-53.
1981: R Contreras; H Cheroutre; Walter Fiers
A simple apparatus for injection of nanoliter quantities into Xenopus laevis oocytes.
Analytical biochemistry 1981;113(1):185-7.
1980: R Derynck; Erik Remaut; E Saman; P Stanssens; E De Clercq; J Content; Walter Fiers
Expression of human fibroblast interferon gene in Escherichia coli.
Nature 1980;287(5779):193-7.
1980: M Verhoeyen; R Fang; Willy Min Jou; R Devos; D Huylebroeck; E Saman; Walter Fiers
Antigenic drift between the haemagglutinin of the Hong Kong influenza strains A/Aichi/2/68 and A/Victoria/3/75.
Nature 1980;286(5775):771-6.
1980: Willy Min Jou; M Verhoeyen; R Devos; E Saman; R Fang; D Huylebroeck; Walter Fiers; G Threlfall; C Barber; N Carey; S Emtage
Complete structure of the hemagglutinin gene from the human influenza A/Victoria/3/75 (H3N2) strain as determined from cloned DNA.
Cell 1980;19(3):683-96.