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Walter Fiers

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
46
Beyaert, Rudi
42
Vandenabeele, Peter
41
Brouckaert, Peter
31
Grooten, Johan
28
van Roy, Frans
26
Remaut, Erik
25
Declercq, Wim
23
Haegeman, Guy
21
Libert, Claude
20
Tavernier, Jan
18
Van de Craen, M
16
Contreras, Roland
15
Saelens, Xavier
15
Jou, Willy Min
13
Devos, R

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Publications

TOP 3
Fiers Walter; De Filette Marina; El Bakkouri Karim; Schepens Bert; Roose Kenny; Schotsaert Michael; Birkett Ashley; Saelens Xavier
M2e-based universal influenza A vaccine.
Schotsaert Michael; De Filette Marina; Fiers Walter; Saelens Xavier
Universal M2 ectodomain-based influenza A vaccines: preclinical and clinical developments.
Roose Kenny; Fiers Walter; Saelens Xavier
Pandemic preparedness: toward a universal influenza vaccine.

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All Publications

2009: Fiers Walter; De Filette Marina; El Bakkouri Karim; Schepens Bert; Roose Kenny; Schotsaert Michael; Birkett Ashley; Saelens Xavier
M2e-based universal influenza A vaccine.
Vaccine 2009;27(45):6280-3.
2009: Schotsaert Michael; De Filette Marina; Fiers Walter; Saelens Xavier
Universal M2 ectodomain-based influenza A vaccines: preclinical and clinical developments.
Expert review of vaccines 2009;8(4):499-508.
2009: Roose Kenny; Fiers Walter; Saelens Xavier
Pandemic preparedness: toward a universal influenza vaccine.
Drug news & perspectives 2009;22(2):80-92.
2008: De Filette Marina; Martens Wouter; Smet Anouk; Schotsaert Michael; Birkett Ashley; Londoño-Arcila Patricia; Fiers Walter; Saelens Xavier
Universal influenza A M2e-HBc vaccine protects against disease even in the presence of pre-existing anti-HBc antibodies.
Vaccine 2008;26(51):6503-7.
2008: De Filette Marina; Martens Wouter; Roose Kenny; Deroo Tom; Vervalle Frederik; Bentahir Mostafa; Vandekerckhove Joel; Fiers Walter; Saelens Xavier
An influenza A vaccine based on tetrameric ectodomain of matrix protein 2.
The Journal of biological chemistry 2008;283(17):11382-7.
2008: Eliasson Dubravka Grdic; El Bakkouri Karim; Schön Karin; Ramne Anna; Festjens Els; Löwenadler Björn; Fiers Walter; Saelens Xavier; Lycke Nils
CTA1-M2e-DD: a novel mucosal adjuvant targeted influenza vaccine.
Vaccine 2008;26(9):1243-52.
2006: De Filette Marina; Fiers Walter; Martens Wouter; Birkett Ashley; Ramne Anna; Löwenadler Björn; Lycke Nils; Jou Willy Min; Saelens Xavier
Improved design and intranasal delivery of an M2e-based human influenza A vaccine.
Vaccine 2006;24(44-46):6597-601.
2006: De Filette Marina; Ramne Anna; Birkett Ashley; Lycke Nils; Löwenadler Björn; Min Jou Willy; Saelens Xavier; Fiers Walter
The universal influenza vaccine M2e-HBc administered intranasally in combination with the adjuvant CTA1-DD provides complete protection.
Vaccine 2006;24(5):544-51.
2005: De Filette Marina; Min Jou Willy; Birkett Ashley; Lyons Katie; Schultz Brian; Tonkyro Anne; Resch Stephanie; Fiers Walter
Universal influenza A vaccine: optimization of M2-based constructs.
Virology 2005;337(1):149-61.
2004: Fiers W; De Filette M; Birkett A; Neirynck S; Min Jou W
A "universal" human influenza A vaccine.
Virus research 2004;103(1-2):173-6.
2004: Brouckaert Peter; Takahashi Nozomi; van Tiel Sandra T; Hostens Jeroen; Eggermont Alexander M M; Seynhaeve Ann L B; Fiers Walter; ten Hagen Timo L M
Tumor necrosis factor-alpha augmented tumor response in B16BL6 melanoma-bearing mice treated with stealth liposomal doxorubicin (Doxil) correlates with altered Doxil pharmacokinetics.
International journal of cancer. Journal international du cancer 2004;109(3):442-8.
2002: Ameloot Paul; Takahashi Nozomi; Everaerdt Bart; Hostens Jeroen; Eugster Hans-Pietro; Fiers Walter; Brouckaert Peter
Bioavailability of recombinant tumor necrosis factor determines its lethality in mice.
European journal of immunology 2002;32(10):2759-65.
2002: Ameloot Paul; Fiers Walter; Buurman Wim A; de Baetselier Patrick; Brouckaert Peter
Characterization of the interaction between murine tumour necrosis factor and monoclonal antibodies.
Cytokine 2002;18(3):158-63.
2001: Fiers W; Neirynck S; Deroo T; Saelens X; Jou W M
Soluble recombinant influenza vaccines.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2001;356(1416):1961-3.
2001: De Wilde G; Mertens N; Boone E; De Vreese B; Van Beeumen J; Fiers W; Haegeman G
Expression in Escherichia coli of the death domain of the human p55 tumor necrosis factor receptor.
Protein expression and purification 2001;23(2):226-32.
2001: Ameloot P; Fiers W; De Bleser P; Ware C F; Vandenabeele P; Brouckaert P
Identification of tumor necrosis factor (TNF) amino acids crucial for binding to the murine p75 TNF receptor and construction of receptor-selective mutants.
The Journal of biological chemistry 2001;276(40):37426-30.
2001: Denecker G; Vercammen D; Steemans M; Vanden Berghe T; Brouckaert G; Van Loo G; Zhivotovsky B; Fiers W; Grooten J; Declercq W; Vandenabeele P
Death receptor-induced apoptotic and necrotic cell death: differential role of caspases and mitochondria.
Cell death and differentiation 2001;8(8):829-40.
2001: Ameloot P; Declercq W; Fiers W; Vandenabeele P; Brouckaert P
Heterotrimers formed by tumor necrosis factors of different species or muteins.
The Journal of biological chemistry 2001;276(29):27098-103.
2000: Schoonjans R; Willems A; Schoonooghe S; Fiers W; Grooten J; Mertens N
Fab chains as an efficient heterodimerization scaffold for the production of recombinant bispecific and trispecific antibody derivatives.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(12):7050-7.
2000: Boone E; Vanden Berghe T; Van Loo G; De Wilde G; De Wael N; Vercammen D; Fiers W; Haegeman G; Vandenabeele P
Structure/Function analysis of p55 tumor necrosis factor receptor and fas-associated death domain. Effect on necrosis in L929sA cells.
The Journal of biological chemistry 2000;275(48):37596-603.
2000: Vancompernolle K; Boonefaes T; Mann M; Fiers W; Grooten J
Tumor necrosis factor-induced microtubule stabilization mediated by hyperphosphorylated oncoprotein 18 promotes cell death.
The Journal of biological chemistry 2000;275(43):33876-82.
2000: Cauwels A; Van Molle W; Janssen B; Everaerdt B; Huang P; Fiers W; Brouckaert P
Protection against TNF-induced lethal shock by soluble guanylate cyclase inhibition requires functional inducible nitric oxide synthase.
Immunity 2000;13(2):223-31.
2000: Steidler L; Hans W; Schotte L; Neirynck S; Obermeier F; Falk W; Fiers W; Remaut E
Treatment of murine colitis by Lactococcus lactis secreting interleukin-10.
Science (New York, N.Y.) 2000;289(5483):1352-5.
2000: Denecker G; Dooms H; Van Loo G; Vercammen D; Grooten J; Fiers W; Declercq W; Vandenabeele P
Phosphatidyl serine exposure during apoptosis precedes release of cytochrome c and decrease in mitochondrial transmembrane potential.
FEBS letters 2000;465(1):47-52.
1999: Fiers W; Beyaert R; Declercq W; Vandenabeele P
More than one way to die: apoptosis, necrosis and reactive oxygen damage.
Oncogene 1999;18(54):7719-30.
1999: Van de Craen M; Declercq W; Van den brande I; Fiers W; Vandenabeele P
The proteolytic procaspase activation network: an in vitro analysis.
Cell death and differentiation 1999;6(11):1117-24.
1999: Neirynck S; Deroo T; Saelens X; Vanlandschoot P; Jou W M; Fiers W
A universal influenza A vaccine based on the extracellular domain of the M2 protein.
Nature medicine 1999;5(10):1157-63.
1999: Van de Craen M; Berx G; Van den Brande I; Fiers W; Declercq W; Vandenabeele P
Proteolytic cleavage of beta-catenin by caspases: an in vitro analysis.
FEBS letters 1999;458(2):167-70.
1999: Libert C; Wielockx B; Grijalba B; Van Molle W; Kremmer E; Colten H R; Fiers W; Brouckaert P
The role of complement activation in tumour necrosis factor-induced lethal hepatitis.
Cytokine 1999;11(8):617-25.
1999: Heyninck K; Denecker G; De Valck D; Fiers W; Beyaert R
Inhibition of tumor necrosis factor-induced necrotic cell death by the zinc finger protein A20.
Anticancer research 1999;19(4B):2863-8.
1999: De Valck D; Jin D Y; Heyninck K; Van de Craen M; Contreras R; Fiers W; Jeang K T; Beyaert R
The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases.
Oncogene 1999;18(29):4182-90.
1999: Heyninck K; De Valck D; Vanden Berghe W; Van Criekinge W; Contreras R; Fiers W; Haegeman G; Beyaert R
The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN.
The Journal of cell biology 1999;145(7):1471-82.
1999: van Criekinge W; Cornelis S; Van De Craen M; Vandenabeele P; Fiers W; Beyaert R
GAL4 is a substrate for caspases: implications for two-hybrid screening and other GAL4-based assays.
Molecular cell biology research communications : MCBRC 1999;1(2):158-61.
1999: Saelens X; Vanlandschoot P; Martinet W; Maras M; Neirynck S; Contreras R; Fiers W; Jou W M
Protection of mice against a lethal influenza virus challenge after immunization with yeast-derived secreted influenza virus hemagglutinin.
European journal of biochemistry / FEBS 1999;260(1):166-75.
1999: van de Craen M; de Jonghe C; van den Brande I; Declercq W; van Gassen G; van Criekinge W; Vanderhoeven I; Fiers W; van Broeckhoven C; Hendriks L; Vandenabeele P
Identification of caspases that cleave presenilin-1 and presenilin-2. Five presenilin-1 (PS1) mutations do not alter the sensitivity of PS1 to caspases.
FEBS letters 1999;445(1):149-54.
1999: Libert C; Wielockx B; Hammond G L; Brouckaert P; Fiers W; Elliott R W
Identification of a locus on distal mouse chromosome 12 that controls resistance to tumor necrosis factor-induced lethal shock.
Genomics 1999;55(3):284-9.
1999: Peppelenbosch M; Boone E; Jones G E; van Deventer S J; Haegeman G; Fiers W; Grooten J; Ridley A J
Multiple signal transduction pathways regulate TNF-induced actin reorganization in macrophages: inhibition of Cdc42-mediated filopodium formation by TNF.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(2):837-45.
1999: Goossens V; De Vos K; Vercammen D; Steemans M; Vancompernolle K; Fiers W; Vandenabeele P; Grooten J
Redox regulation of TNF signaling.
BioFactors (Oxford, England) 1999;10(2-3):145-56.
1998: Decoster E; Cornelis S; Vanhaesebroeck B; Fiers W
Autocrine tumor necrosis factor (TNF) and lymphotoxin (LT) alpha differentially modulate cellular sensitivity to TNF/LT-alpha cytotoxicity in L929 cells.
The Journal of cell biology 1998;143(7):2057-65.
1998: Van de Craen M; Van Loo G; Declercq W; Schotte P; Van den brande I; Mandruzzato S; van der Bruggen P; Fiers W; Vandenabeele P
Molecular cloning and identification of murine caspase-8.
Journal of molecular biology 1998;284(4):1017-26.
1998: De Valck D; Vercammen D; Fiers W; Beyaert R
Differential activation of phospholipases during necrosis or apoptosis: a comparative study using tumor necrosis factor and anti-Fas antibodies.
Journal of cellular biochemistry 1998;71(3):392-9.
1998: Libert C; Hochepied T; Berger F G; Baumann H; Fiers W; Brouckaert P
High-level constitutive expression of alpha 1-acid glycoprotein and lack of protection against tumor necrosis factor-induced lethal shock in transgenic mice.
Transgenic research 1998;7(6):429-35.
1998: Vancompernolle K; Van Herreweghe F; Pynaert G; Van de Craen M; De Vos K; Totty N; Sterling A; Fiers W; Vandenabeele P; Grooten J
Atractyloside-induced release of cathepsin B, a protease with caspase-processing activity.
FEBS letters 1998;438(3):150-8.
1998: Rottiers P; Verfaillie T; Contreras R; Revets H; Desmedt M; Dooms H; Fiers W; Grooten J
Differentiation of EL4 lymphoma cells by tumoral environment is associated with inappropriate expression of the large chondroitin sulfate proteoglycan PG-M and the tumor-associated antigen HTgp-175.
International journal of cancer. Journal international du cancer 1998;78(4):503-10.
1998: Van de Craen M; Van Loo G; Pype S; Van Criekinge W; Van den brande I; Molemans F; Fiers W; Declercq W; Vandenabeele P
Identification of a new caspase homologue: caspase-14.
Cell death and differentiation 1998;5(10):838-46.
1998: Schotte P; Van Criekinge W; Van de Craen M; Van Loo G; Desmedt M; Grooten J; Cornelissen M; De Ridder L; Vandekerckhove J; Fiers W; Vandenabeele P; Beyaert R
Cathepsin B-mediated activation of the proinflammatory caspase-11.
Biochemical and biophysical research communications 1998;251(1):379-87.
1998: Van Criekinge W; van Gurp M; Decoster E; Schotte P; Van de Craen M; Fiers W; Vandenabeele P; Beyaert R
Use of the yeast three-hybrid system as a tool to study caspases.
Analytical biochemistry 1998;263(1):62-6.
1998: Vercammen D; Brouckaert G; Denecker G; Van de Craen M; Declercq W; Fiers W; Vandenabeele P
Dual signaling of the Fas receptor: initiation of both apoptotic and necrotic cell death pathways.
The Journal of experimental medicine 1998;188(5):919-30.
1998: Dooms H; Desmedt M; Vancaeneghem S; Rottiers P; Goossens V; Fiers W; Grooten J
Quiescence-inducing and antiapoptotic activities of IL-15 enhance secondary CD4+ T cell responsiveness to antigen.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(5):2141-50.
1998: Vanlandschoot P; Beirnaert E; Barrère B; Calder L; Millar B; Wharton S; Jou W M; Fiers W
An antibody which binds to the membrane-proximal end of influenza virus haemagglutinin (H3 subtype) inhibits the low-pH-induced conformational change and cell-cell fusion but does not neutralize virus.
The Journal of general virology 1998;79 ( Pt 7)():1781-91.
1998: Declercq W; Denecker G; Fiers W; Vandenabeele P
Cooperation of both TNF receptors in inducing apoptosis: involvement of the TNF receptor-associated factor binding domain of the TNF receptor 75.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(1):390-9.
1998: Desmedt M; Rottiers P; Dooms H; Fiers W; Grooten J
Macrophages induce cellular immunity by activating Th1 cell responses and suppressing Th2 cell responses.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(11):5300-8.
1998: Vercammen D; Beyaert R; Denecker G; Goossens V; Van Loo G; Declercq W; Grooten J; Fiers W; Vandenabeele P
Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor.
The Journal of experimental medicine 1998;187(9):1477-85.
1998: De Vos K; Goossens V; Boone E; Vercammen D; Vancompernolle K; Vandenabeele P; Haegeman G; Fiers W; Grooten J
The 55-kDa tumor necrosis factor receptor induces clustering of mitochondria through its membrane-proximal region.
The Journal of biological chemistry 1998;273(16):9673-80.
1998: Carpentier I; Declercq W; Malinin N L; Wallach D; Fiers W; Beyaert R
TRAF2 plays a dual role in NF-kappaB-dependent gene activation by mediating the TNF-induced activation of p38 MAPK and IkappaB kinase pathways.
FEBS letters 1998;425(2):195-8.
1998: Vanden Berghe W; Plaisance S; Boone E; De Bosscher K; Schmitz M L; Fiers W; Haegeman G
p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways are required for nuclear factor-kappaB p65 transactivation mediated by tumor necrosis factor.
The Journal of biological chemistry 1998;273(6):3285-90.
1998: Decoster E; Vanhaesebroeck B; Boone E; Plaisance S; De Vos K; Haegeman G; Grooten J; Fiers W
Induction of unresponsiveness to tumor necrosis factor (TNF) after autocrine TNF expression requires TNF membrane retention.
The Journal of biological chemistry 1998;273(6):3271-7.
1998: Steidler L; Viaene J; Fiers W; Remaut E
Functional display of a heterologous protein on the surface of Lactococcus lactis by means of the cell wall anchor of Staphylococcus aureus protein A.
Applied and environmental microbiology 1998;64(1):342-5.
1998: Martinet W; Deroo T; Saelens X; Beirnaert E; Vanlandschoot P; Contreras R; Fiers W; Min Jou W
Evaluation of recombinant A/Victoria/3/75 (H3N2) influenza neuraminidase mutants as potential broad-spectrum subunit vaccines against influenza A.
Archives of virology 1998;143(10):2011-9.
1998: Vanlandschoot P; Beirnaert E; Grooten J; Jou W M; Fiers W
pH-dependent aggregation and secretion of soluble monomeric influenza hemagglutinin.
Archives of virology 1998;143(2):227-39.
1997: De Bosscher K; Schmitz M L; Vanden Berghe W; Plaisance S; Fiers W; Haegeman G
Glucocorticoid-mediated repression of nuclear factor-kappaB-dependent transcription involves direct interference with transactivation.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(25):13504-9.
1997: Maras M; Saelens X; Laroy W; Piens K; Claeyssens M; Fiers W; Contreras R
In vitro conversion of the carbohydrate moiety of fungal glycoproteins to mammalian-type oligosaccharides--evidence for N-acetylglucosaminyltransferase-I-accepting glycans from Trichoderma reesei.
European journal of biochemistry / FEBS 1997;249(3):701-7.
1997: Vercammen D; Vandenabeele P; Beyaert R; Declercq W; Fiers W
Tumour necrosis factor-induced necrosis versus anti-Fas-induced apoptosis in L929 cells.
Cytokine 1997;9(11):801-8.
1997: Decoster E; Vandevoorde V; Beyaert R; Haegeman G; Fiers W
Resistance to tumor necrosis factor (TNF) cytotoxicity by autocrine TNF production is independent of intracellular signaling pathways.
FEBS letters 1997;416(2):183-6.
1997: Van Molle W; Libert C; Fiers W; Brouckaert P
Alpha 1-acid glycoprotein and alpha 1-antitrypsin inhibit TNF-induced but not anti-Fas-induced apoptosis of hepatocytes in mice.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(7):3555-64.
1997: Denecker G; Vandenabeele P; Grooten J; Penning L C; Declercq W; Beyaert R; Buurman W A; Fiers W
Differential role of calcium in tumour necrosis factor-mediated apoptosis and secretion of granulocyte-macrophage colony-stimulating factor in a T cell hybridoma.
Cytokine 1997;9(9):631-8.
1997: De Valck D; Heyninck K; Van Criekinge W; Vandenabeele P; Fiers W; Beyaert R
A20 inhibits NF-kappaB activation independently of binding to 14-3-3 proteins.
Biochemical and biophysical research communications 1997;238(2):590-4.
1997: Martinet W; Saelens X; Deroo T; Neirynck S; Contreras R; Min Jou W; Fiers W
Protection of mice against a lethal influenza challenge by immunization with yeast-derived recombinant influenza neuraminidase.
European journal of biochemistry / FEBS 1997;247(1):332-8.
1997: Lucas R; Juillard P; Decoster E; Redard M; Burger D; Donati Y; Giroud C; Monso-Hinard C; De Kesel T; Buurman W A; Moore M W; Dayer J M; Fiers W; Bluethmann H; Grau G E
Crucial role of tumor necrosis factor (TNF) receptor 2 and membrane-bound TNF in experimental cerebral malaria.
European journal of immunology 1997;27(7):1719-25.
1997: Plaisance S; Vanden Berghe W; Boone E; Fiers W; Haegeman G
Recombination signal sequence binding protein Jkappa is constitutively bound to the NF-kappaB site of the interleukin-6 promoter and acts as a negative regulatory factor.
Molecular and cellular biology 1997;17(7):3733-43.
1997: Barge R M; Willemze R; Vandenabeele P; Fiers W; Beyaert R
Differential involvement of caspases in apoptosis of myeloid leukemic cells induced by chemotherapy versus growth factor withdrawal.
FEBS letters 1997;409(2):207-10.
1997: Vandevoorde V; Haegeman G; Fiers W
Induced expression of trimerized intracellular domains of the human tumor necrosis factor (TNF) p55 receptor elicits TNF effects.
The Journal of cell biology 1997;137(7):1627-38.
1997: Laroy W; Maras M; Fiers W; Contreras R
A radioactive assay for sialyltransferase activity using 96-well multiscreen filtration plates.
Analytical biochemistry 1997;249(1):108-11.
1997: Maras M; De Bruyn A; Schraml J; Herdewijn P; Claeyssens M; Fiers W; Contreras R
Structural characterization of N-linked oligosaccharides from cellobiohydrolase I secreted by the filamentous fungus Trichoderma reesei RUTC 30.
European journal of biochemistry / FEBS 1997;245(3):617-25.
1997: Van de Craen M; Van den Brande I; Declercq W; Irmler M; Beyaert R; Tschopp J; Fiers W; Vandenabeele P
Cleavage of caspase family members by granzyme B: a comparative study in vitro.
European journal of immunology 1997;27(5):1296-9.
1997: Beyaert R; Kidd V J; Cornelis S; Van de Craen M; Denecker G; Lahti J M; Gururajan R; Vandenabeele P; Fiers W
Cleavage of PITSLRE kinases by ICE/CASP-1 and CPP32/CASP-3 during apoptosis induced by tumor necrosis factor.
The Journal of biological chemistry 1997;272(18):11694-7.
1997: Van de Craen M; Vandenabeele P; Declercq W; Van den Brande I; Van Loo G; Molemans F; Schotte P; Van Criekinge W; Beyaert R; Fiers W
Characterization of seven murine caspase family members.
FEBS letters 1997;403(1):61-9.
1996: Mertens N; Remaut E; Fiers W
Increased stability of phage T7g10 mRNA is mediated by either a 5'- or a 3'-terminal stem-loop structure.
Biological chemistry 1996;377(12):811-7.
1996: Libert C; Van Molle W; Brouckaert P; Fiers W
alpha1-Antitrypsin inhibits the lethal response to TNF in mice.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(11):5126-9.
1996: Van Criekinge W; Beyaert R; Van de Craen M; Vandenabeele P; Schotte P; De Valck D; Fiers W
Functional characterization of the prodomain of interleukin-1beta-converting enzyme.
The Journal of biological chemistry 1996;271(44):27245-8.
1996: Hack V; Gross A; Kinscherf R; Bockstette M; Fiers W; Berke G; Dröge W
Abnormal glutathione and sulfate levels after interleukin 6 treatment and in tumor-induced cachexia.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1996;10(10):1219-26.
1996: Steidler L; Yu W; Fiers W; Remaut E
The expression of the Photinus pyralis luciferase gene in Staphylococcus aureus Cowan I allows the development of a live amplifiable tool for immunodetection.
Applied and environmental microbiology 1996;62(7):2356-9.
1996: Cauwels A; Fiers W; Brouckaert P
Murine IL-12 is involved in Calmette-Guérin bacillus-induced sensitization and is by itself sufficient to sensitize mice to the lethal effects of human TNF1.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(12):4686-90.
1996: De Valck D; Heyninck K; Van Criekinge W; Contreras R; Beyaert R; Fiers W
A20, an inhibitor of cell death, self-associates by its zinc finger domain.
FEBS letters 1996;384(1):61-4.
1996: Deroo T; Jou W M; Fiers W
Recombinant neuraminidase vaccine protects against lethal influenza.
Vaccine 1996;14(6):561-9.
1996: Beyaert R; Cuenda A; Vanden Berghe W; Plaisance S; Lee J C; Haegeman G; Cohen P; Fiers W
The p38/RK mitogen-activated protein kinase pathway regulates interleukin-6 synthesis response to tumor necrosis factor.
The EMBO journal 1996;15(8):1914-23.
1996: Goossens V; Grooten J; Fiers W
The oxidative metabolism of glutamine. A modulator of reactive oxygen intermediate-mediated cytotoxicity of tumor necrosis factor in L929 fibrosarcoma cells.
The Journal of biological chemistry 1996;271(1):192-6.
1996: Vanlandschoot P; Beirnaert E; Neirynck S; Saelens X; Jou W M; Fiers W
Molecular and immunological characterization of soluble aggregated A/Victoria/3/75 (H3N2) influenza haemagglutinin expressed in insect cells.
Archives of virology 1996;141(9):1715-26.
1995: Takahashi N; Fiers W; Brouckaert P
Anti-tumor activity of tumor necrosis factor in combination with interferon-gamma is not affected by prior tolerization.
International journal of cancer. Journal international du cancer 1995;63(6):846-54.
1995: Declercq W; Vandenabeele P; Fiers W
Dimerization of chimeric erythropoietin/75 kDa tumour necrosis factor (TNF) receptors transduces TNF signals: necessity for the 75 kDa-TNF receptor transmembrane domain.
Cytokine 1995;7(7):701-9.
1995: Mertens N; Remaut E; Fiers W
Versatile, multi-featured plasmids for high-level expression of heterologous genes in Escherichia coli: overproduction of human and murine cytokines.
Gene 1995;164(1):9-15.
1995: Vanlandschoot P; Beirnaert E; Dewilde S; Saelens X; Bestebroer T; De Jong J; Jou W M; Fiers W
A fairly conserved epitope on the hemagglutinin of influenza A (H3N2) virus with variable accessibility to neutralizing antibody.
Virology 1995;212(2):526-34.
1995: Beyaert R; Vanhaesebroeck B; Declercq W; Van Lint J; Vandenabele P; Agostinis P; Vandenheede J R; Fiers W
Casein kinase-1 phosphorylates the p75 tumor necrosis factor receptor and negatively regulates tumor necrosis factor signaling for apoptosis.
The Journal of biological chemistry 1995;270(40):23293-9.
1995: Flamez D; Remaut E; Fiers W
Production in Escherichia coli of a functional murine and murine::human chimeric F(ab')2 fragment and mature antibody directed against human placental alkaline phosphatase.
Journal of biotechnology 1995;42(2):133-43.
1995: Robbens J; Raeymaekers A; Steidler L; Fiers W; Remaut E
Production of soluble and active recombinant murine interleukin-2 in Escherichia coli: high level expression, Kil-induced release, and purification.
Protein expression and purification 1995;6(4):481-6.
1995: Goossens V; Grooten J; De Vos K; Fiers W
Direct evidence for tumor necrosis factor-induced mitochondrial reactive oxygen intermediates and their involvement in cytotoxicity.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(18):8115-9.
1995: Takahashi N; Brouckaert P; Fiers W
Mechanism of tolerance to tumor necrosis factor: receptor-specific pathway and selectivity.
The American journal of physiology 1995;269(2 Pt 2):R398-405.
1995: Decoster E; Vanhaesebroeck B; Vandenabeele P; Grooten J; Fiers W
Generation and biological characterization of membrane-bound, uncleavable murine tumor necrosis factor.
The Journal of biological chemistry 1995;270(31):18473-8.
1995: Vercammen D; Vandenabeele P; Declercq W; Van de Craen M; Grooten J; Fiers W
Cytotoxicity in L929 murine fibrosarcoma cells after triggering of transfected human p75 tumour necrosis factor (TNF) receptor is mediated by endogenous murine TNF.
Cytokine 1995;7(5):463-70.
1995: Los M; Van de Craen M; Penning L C; Schenk H; Westendorp M; Baeuerle P A; Dröge W; Krammer P H; Fiers W; Schulze-Osthoff K
Requirement of an ICE/CED-3 protease for Fas/APO-1-mediated apoptosis.
Nature 1995;375(6526):81-3.
1995: Steidler L; Wells J M; Raeymaekers A; Vandekerckhove J; Fiers W; Remaut E
Secretion of biologically active murine interleukin-2 by Lactococcus lactis subsp. lactis.
Applied and environmental microbiology 1995;61(4):1627-9.
1995: Vandenabeele P; Declercq W; Vanhaesebroeck B; Grooten J; Fiers W
Both TNF receptors are required for TNF-mediated induction of apoptosis in PC60 cells.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(6):2904-13.
1995: Cauwels A; Brouckaert P; Grooten J; Huang S; Aguet M; Fiers W
Involvement of IFN-gamma in Bacillus Calmette-Guérin-induced but not in tumor-induced sensitization to TNF-induced lethality.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(6):2753-63.
1995: Mertens N; Remaut E; Fiers W
Tight transcriptional control mechanism ensures stable high-level expression from T7 promoter-based expression plasmids.
Bio/technology (Nature Publishing Company) 1995;13(2):175-9.
1995: Fiers W; Beyaert R; Boone E; Cornelis S; Declercq W; Decoster E; Denecker G; Depuydt B; De Valck D; De Wilde G; Goossens V; Grooten J; Haegeman G; Heyninck K; Penning L; Plaisance S; Vancompernolle K; Van Criekinge W; Vandenabeele P; Vanden Berghe W; Van de Craen M; Vandevoorde V; Vercammen D
TNF-induced intracellular signaling leading to gene induction or to cytotoxicity by necrosis or by apoptosis.
Journal of inflammation 1995;47(1-2):67-75.
1995: Brouckaert P; Libert C; Cauwels A; Everaerdt B; Van Molle W; Ameloot P; Gansemans Y; Grijalba B; Takahashi N; Truong M J; Van Leuven P; Fiers W
Inhibition of and sensitization to the lethal effects of tumor necrosis factor.
Journal of inflammation 1995;47(1-2):18-26.
1995: Libert C; Van Molle W; Brouckaert P; Fiers W
Platelet-activating factor is a mediator in tumor necrosis factor/galactosamine-induced lethality.
Journal of inflammation 1995;46(3):139-43.
1994: Libert C; Brouckaert P; Fiers W
Protection by alpha 1-acid glycoprotein against tumor necrosis factor-induced lethality.
The Journal of experimental medicine 1994;180(4):1571-5.
1994: Libert C; Takahashi N; Cauwels A; Brouckaert P; Bluethmann H; Fiers W
Response of interleukin-6-deficient mice to tumor necrosis factor-induced metabolic changes and lethality.
European journal of immunology 1994;24(9):2237-42.
1994: Logghe M; Molemans F; Fiers W; Contreras R
The two genes encoding yeast ribosomal protein S8 reside on different chromosomes, and are closely linked to the hsp70 stress protein genes SSA3 and SSA4.
Yeast (Chichester, England) 1994;10(8):1093-1100.
1994: Brouckaert P; Ameloot P; Cauwels A; Everaerdt B; Libert C; Takahashi N; Van Molle W; Fiers W
Receptor-selective mutants of tumour necrosis factor in the therapy of cancer: preclinical studies.
Circulatory shock 1994;43(4):185-90.
1994: Everaerdt B; Brouckaert P; Fiers W
Recombinant IL-1 receptor antagonist protects against TNF-induced lethality in mice.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(10):5041-9.
1994: Takahashi N; Brouckaert P; Bemelmans M H; Buurman W A; Fiers W
Mechanism of induction of tolerance to tumour necrosis factor (TNF): no involvement of modulators of TNF bioavailability or receptor binding.
Cytokine 1994;6(3):235-42.
1994: Vanhoenacker P; Fiers W; Haegeman G
Studies on the induction of the interleukin-6 promoter in cell lines of human and simian origin.
European cytokine network 1994;5(3):283-91.
1994: De Sutter K; Hostens K; Vandekerckhove J; Fiers W
Production of enzymatically active rat protein disulfide isomerase in Escherichia coli.
Gene 1994;141(2):163-70.
1994: Van Ostade X; Vandenabeele P; Tavernier J; Fiers W
Human tumor necrosis factor mutants with preferential binding to and activity on either the R55 or R75 receptor.
European journal of biochemistry / FEBS 1994;220(3):771-9.
1994: De Sutter K; Fiers W
A bifunctional murine::human chimeric antibody with one antigen-binding arm replaced by bacterial beta-lactamase.
Molecular immunology 1994;31(4):261-7.
1994: Beyaert R; Fiers W
Molecular mechanisms of tumor necrosis factor-induced cytotoxicity. What we do understand and what we do not.
FEBS letters 1994;340(1-2):9-16.
1994: Demolder J; Fiers W; Contreras R
Human interferon-beta, expressed in Saccharomyces cerevisiae, is predominantly directed to the vacuoles. Influence of modified co-expression of secretion factors and chaperones.
Journal of biotechnology 1994;32(2):179-89.
1994: Barbara J A; Smith W B; Gamble J R; Van Ostade X; Vandenabeele P; Tavernier J; Fiers W; Vadas M A; Lopez A F
Dissociation of TNF-alpha cytotoxic and proinflammatory activities by p55 receptor- and p75 receptor-selective TNF-alpha mutants.
The EMBO journal 1994;13(4):843-50.
1994: Van Ostade X; Tavernier J; Fiers W
Structure-activity studies of human tumour necrosis factors.
Protein engineering 1994;7(1):5-22.
1993: Steidler L; Remaut E; Fiers W
Pap pili as a vector system for surface exposition of an immunoglobulin G-binding domain of protein A of Staphylococcus aureus in Escherichia coli.
Journal of bacteriology 1993;175(23):7639-43.
1993: Grooten J; Goossens V; Vanhaesebroeck B; Fiers W
Cell membrane permeabilization and cellular collapse, followed by loss of dehydrogenase activity: early events in tumour necrosis factor-induced cytotoxicity.
Cytokine 1993;5(6):546-55.
1993: Vanlandschoot P; Maertens G; Jou W M; Fiers W
Recombinant secreted haemagglutinin protects mice against a lethal challenge of influenza virus.
Vaccine 1993;11(12):1185-7.
1993: Schulze-Osthoff K; Beyaert R; Vandevoorde V; Haegeman G; Fiers W
Depletion of the mitochondrial electron transport abrogates the cytotoxic and gene-inductive effects of TNF.
The EMBO journal 1993;12(8):3095-104.
1993: Beyaert R; Heyninck K; De Valck D; Boeykens F; van Roy F; Fiers W
Enhancement of tumor necrosis factor cytotoxicity by lithium chloride is associated with increased inositol phosphate accumulation.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(1):291-300.
1993: Beyaert R; Vanhaesebroeck B; Heyninck K; Boone E; De Valck D; Schulze-Osthoff K; Haegeman G; Van Roy F; Fiers W
Sensitization of tumor cells to tumor necrosis factor action by the protein kinase inhibitor staurosporine.
Cancer research 1993;53(11):2623-30.
1993: Guisez Y; Demolder J; Mertens N; Raeymaekers A; Plaetinck G; Robbens J; Vandekerckhove J; Remaut E; Fiers W
High-level expression, purification, and renaturation of recombinant murine interleukin-2 from Escherichia coli.
Protein expression and purification 1993;4(3):240-6.
1993: Vandenabeele P; Abramowicz D; Berus D; Van der Heyden J; Grooten J; Donckier V; Hooghe-Peters E L; Goldman M; Fiers W
Increased IL-6 production and IL-6-mediated Ig secretion in murine host-vs-graft disease.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(9):4179-87.
1993: Guisez Y; Robbens J; Remaut E; Fiers W
Folding of the MS2 coat protein in Escherichia coli is modulated by translational pauses resulting from mRNA secondary structure and codon usage: a hypothesis.
Journal of theoretical biology 1993;162(2):243-52.
1993: Vanhaesebroeck B; Reed J C; De Valck D; Grooten J; Miyashita T; Tanaka S; Beyaert R; Van Roy F; Fiers W
Effect of bcl-2 proto-oncogene expression on cellular sensitivity to tumor necrosis factor-mediated cytotoxicity.
Oncogene 1993;8(4):1075-81.
1993: Brouckaert P; Libert C; Everaerdt B; Takahashi N; Cauwels A; Fiers W
Tumor necrosis factor, its receptors and the connection with interleukin 1 and interleukin 6.
Immunobiology 1993;187(3-5):317-29.
1993: De Valck D; Beyaert R; Van Roy F; Fiers W
Tumor necrosis factor cytotoxicity is associated with phospholipase D activation.
European journal of biochemistry / FEBS 1993;212(2):491-7.
1993: Demolder J; De Backer M; Fiers W; Contreras R
Phenotypic effects in Saccharomyces cerevisiae after regulated expression of beta-(1,3)-glucanase from Nicotiana plumbaginifolia.
Journal of biotechnology 1993;27(3):295-305.
1993: Steidler L; Remaut E; Fiers W
LamB as a carrier molecule for the functional exposition of IgG-binding domains of the Staphylococcus aureus protein A at the surface of Escherichia coli K12.
Molecular & general genetics : MGG 1993;236(2-3):187-92.
1993: Van Ostade X; Vandenabeele P; Everaerdt B; Loetscher H; Gentz R; Brockhaus M; Lesslauer W; Tavernier J; Brouckaert P; Fiers W
Human TNF mutants with selective activity on the p55 receptor.
Nature 1993;361(6409):266-9.
1993: Patestos N P; Haegeman G; Vandevoorde V; Fiers W
Activation of the nuclear factor kappa B is not sufficient for regulation of tumor necrosis factor-induced interleukin-6 gene expression.
Biochimie 1993;75(11):1007-18.
1992: Van Lint J; Agostinis P; Vandevoorde V; Haegeman G; Fiers W; Merlevede W; Vandenheede J R
Tumor necrosis factor stimulates multiple serine/threonine protein kinases in Swiss 3T3 and L929 cells. Implication of casein kinase-2 and extracellular signal-regulated kinases in the tumor necrosis factor signal transduction pathway.
The Journal of biological chemistry 1992;267(36):25916-21.
1992: Vandenabeele P; Declercq W; Vercammen D; Van de Craen M; Grooten J; Loetscher H; Brockhaus M; Lesslauer W; Fiers W
Functional characterization of the human tumor necrosis factor receptor p75 in a transfected rat/mouse T cell hybridoma.
The Journal of experimental medicine 1992;176(4):1015-24.
1992: Libert C; Vink A; Coulie P; Brouckaert P; Everaerdt B; Van Snick J; Fiers W
Limited involvement of interleukin-6 in the pathogenesis of lethal septic shock as revealed by the effect of monoclonal antibodies against interleukin-6 or its receptor in various murine models.
European journal of immunology 1992;22(10):2625-30.
1992: Brouckaert P; Libert C; Everaerdt B; Fiers W
Selective species specificity of tumor necrosis factor for toxicity in the mouse.
Lymphokine and cytokine research 1992;11(4):193-6.
1992: De Sutter K; Remaut E; Fiers W
Disulphide bridge formation in the periplasm of Escherichia coli: beta-lactamase:: human IgG3 hinge fusions as a model system.
Molecular microbiology 1992;6(15):2201-8.
1992: Beyaert R; Schulze-Osthoff K; Van Roy F; Fiers W
Synergistic induction of interleukin-6 by tumor necrosis factor and lithium chloride in mice: possible role in the triggering and exacerbation of psoriasis by lithium treatment.
European journal of immunology 1992;22(8):2181-4.
1992: Vanhaesebroeck B; Decoster E; Van Ostade X; Van Bladel S; Lenaerts A; Van Roy F; Fiers W
Expression of an exogenous tumor necrosis factor (TNF) gene in TNF-sensitive cell lines confers resistance to TNF-mediated cell lysis.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(9):2785-94.
1992: Vandevoorde V; Haegeman G; Fiers W
TNF-mediated IL6 gene expression and cytotoxicity are co-inducible in TNF-resistant L929 cells.
FEBS letters 1992;302(3):235-8.
1992: Devos K; Duerinck F; Van Audenhove K; Fiers W
Cloning and expression of the canine interferon-gamma gene.
Journal of interferon research 1992;12(2):95-102.
1992: De Sutter K; Feys V; Van de Voorde A; Fiers W
Production of functionally active murine and murine::human chimeric F(ab')2 fragments in COS-1 cells.
Gene 1992;113(2):223-30.
1992: Brouckaert P; Everaerdt B; Fiers W
The glucocorticoid antagonist RU38486 mimics interleukin-1 in its sensitization to the lethal and interleukin-6-inducing properties of tumor necrosis factor.
European journal of immunology 1992;22(4):981-6.
1992: Schulze-Osthoff K; Bakker A C; Vanhaesebroeck B; Beyaert R; Jacob W A; Fiers W
Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation.
The Journal of biological chemistry 1992;267(8):5317-23.
1992: Patestos N P; Haegeman G; Fiers W
TNF-induced, cytotoxicity-linked IL6 gene expression in L929 cells may require factors other than NF-kappa B.
Biochemical Society transactions 1992;20(1):80S.
1992: Demolder J; Fiers W; Contreras R
Efficient synthesis of secreted murine interleukin-2 by Saccharomyces cerevisiae: influence of 3'-untranslated regions and codon usage.
Gene 1992;111(2):207-13.
1991: Franco L; Jiménez A; Demolder J; Molemans F; Fiers W; Contreras R
The nucleotide sequence of a third cyclophilin-homologous gene from Saccharomyces cerevisiae.
Yeast (Chichester, England) 1991;7(9):971-9.
1991: Vandevoorde V; Haegeman G; Fiers W
Tumor necrosis factor-induced interleukin-6 expression and cytotoxicity follow a common signal transduction pathway in L929 cells.
Biochemical and biophysical research communications 1991;178(3):993-1001.
1991: Libert C; Van Bladel S; Brouckaert P; Fiers W
The influence of modulating substances on tumor necrosis factor and interleukin-6 levels after injection of murine tumor necrosis factor or lipopolysaccharide in mice.
Journal of immunotherapy : official journal of the Society for Biological Therapy 1991;10(4):227-35.
1991: Vleminckx K; Vakaet L; Mareel M; Fiers W; van Roy F
Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role.
Cell 1991;66(1):107-19.
1991: Vandenabeele P; Fiers W
Is amyloidogenesis during Alzheimer's disease due to an IL-1-/IL-6-mediated 'acute phase response' in the brain?
Immunology today 1991;12(7):217-9.
1991: Beyaert R; Schulze-Osthoff K; Van Roy F; Fiers W
Lithium chloride potentiates tumor necrosis factor-induced and interleukin 1-induced cytokine and cytokine receptor expression.
Cytokine 1991;3(4):284-91.
1991: Fiers W
Tumor necrosis factor. Characterization at the molecular, cellular and in vivo level.
FEBS letters 1991;285(2):199-212.
1991: Guisez Y; Tison B; Vandekerckhove J; Demolder J; Bauw G; Haegeman G; Fiers W; Contreras R
Production and purification of recombinant human interleukin-6 secreted by the yeast Saccharomyces cerevisiae.
European journal of biochemistry / FEBS 1991;198(1):217-22.
1991: Vanhaesebroeck B; Van Bladel S; Lenaerts A; Suffys P; Beyaert R; Lucas R; Van Roy F; Fiers W
Two discrete types of tumor necrosis factor-resistant cells derived from the same cell line.
Cancer research 1991;51(9):2469-77.
1991: Takahashi N; Brouckaert P; Fiers W
Induction of tolerance allows separation of lethal and antitumor activities of tumor necrosis factor in mice.
Cancer research 1991;51(9):2366-72.
1991: Mareel M M; Behrens J; Birchmeier W; De Bruyne G K; Vleminckx K; Hoogewijs A; Fiers W C; Van Roy F M
Down-regulation of E-cadherin expression in Madin Darby canine kidney (MDCK) cells inside tumors of nude mice.
International journal of cancer. Journal international du cancer 1991;47(6):922-8.
1991: Van Ostade X; Tavernier J; Prangé T; Fiers W
Localization of the active site of human tumour necrosis factor (hTNF) by mutational analysis.
The EMBO journal 1991;10(4):827-36.
1991: Vanhaesebroeck B; Mareel M; Van Roy F; Grooten J; Fiers W
Expression of the tumor necrosis factor gene in tumor cells correlates with reduced tumorigenicity and reduced invasiveness in vivo.
Cancer research 1991;51(8):2229-38.
1991: Libert C; Van Bladel S; Brouckaert P; Shaw A; Fiers W
Involvement of the liver, but not of IL-6, in IL-1-induced desensitization to the lethal effects of tumor necrosis factor.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(8):2625-32.
1991: Contreras R; Carrez D; Kinghorn J R; van den Hondel C A; Fiers W
Efficient KEX2-like processing of a glucoamylase-interleukin-6 fusion protein by Aspergillus nidulans and secretion of mature interleukin-6.
Bio/technology (Nature Publishing Company) 1991;9(4):378-81.
1991: Beyaert R; De Potter C; Vanhaesebroeck B; Van Roy F; Fiers W
Induction of inflammatory cell infiltration and necrosis in normal mouse skin by the combined treatment of tumor necrosis factor and lithium chloride.
The American journal of pathology 1991;138(3):727-39.
1991: Van Bladel S; Libert C; Fiers W
Interleukin-6 enhances the expression of tumor necrosis factor receptors on hepatoma cells and hepatocytes.
Cytokine 1991;3(2):149-54.
1991: Suffys P; Beyaert R; De Valck D; Vanhaesebroeck B; Van Roy F; Fiers W
Tumour-necrosis-factor-mediated cytotoxicity is correlated with phospholipase-A2 activity, but not with arachidonic acid release per se.
European journal of biochemistry / FEBS 1991;195(2):465-75.
1991: Fiers W
Molecular biology approaches to cancer and to cancer therapy.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 1991;122():1-8.
1990: Vandenabeele P; Declercq W; Libert C; Fiers W
Development of a simple, sensitive and specific bioassay for interleukin-1 based on the proliferation of RPMI 1788 cells. Comparison with other bioassays for IL-1.
Journal of immunological methods 1990;135(1-2):25-32.
1990: Carrez D; Janssens W; Degrave P; van den Hondel C A; Kinghorn J R; Fiers W; Contreras R
Heterologous gene expression by filamentous fungi: secretion of human interleukin-6 by Aspergillus nidulans.
Gene 1990;94(2):147-54.
1990: Van Roy F; Mareel M; Vleminckx K; Beyaert R; Fiers W; Devleeschouwer N; Muquardt C; Legros N; Bracke M; Leclercq G
Hormone sensitivity in vitro and in vivo of v-ras-transfected MCF-7 cell derivatives.
International journal of cancer. Journal international du cancer 1990;46(3):522-32.
1990: Vanhaesebroeck B; Timmers H T; Pronk G J; van Roy F; Van der Eb A J; Fiers W
Modulation of cellular susceptibility to the cytotoxic/cytostatic action of tumor necrosis factor by adenovirus E1 gene expression is cell type-dependent.
Virology 1990;176(2):362-8.
1990: Libert C; Brouckaert P; Shaw A; Fiers W
Induction of interleukin 6 by human and murine recombinant interleukin 1 in mice.
European journal of immunology 1990;20(3):691-4.
1990: Beyaert R; Suffys P; Van Roy F; Fiers W
Inhibition by glucocorticoids of tumor necrosis factor-mediated cytotoxicity. Evidence against lipocortin involvement.
FEBS letters 1990;262(1):93-6.
1990: Van Roy F; Liebaut G; Mareel M; Fiers W
Partial transformation of human tumor cell lines showing defective interaction between unusual p53 gene product and SV40 large-T antigen.
Oncogene 1990;5(2):207-18.
1990: Vanhaesebroeck B; Cragoe E J; Pouysségur J; Beyaert R; Van Roy F; Fiers W
Cytotoxic activity of tumor necrosis factor is inhibited by amiloride derivatives without involvement of the Na+/H+ antiporter.
FEBS letters 1990;261(2):319-22.
1990: Vandenabeele P; Guisez Y; Declercq W; Bauw G; Vandekerckhove J; Fiers W
Response of murine cell lines to an IL-1/IL-2-induced factor in a rat/mouse T hybridoma (PC60): differential induction of cytokines by human IL-1 alpha and IL-1 beta and partial amino acid sequence of rat GM-CSF.
Lymphokine research 1990;9(3):381-9.
1990: Fiers W; Beyaert R; Brouckaert P; Everaerdt B; Grooten J; Lenaerts A; Libert C; Suffys P; Takahashi N; Tavernier J
Tumour necrosis factor: mechanism of action at the molecular, cellular and in vivo level.
Scandinavian journal of clinical and laboratory investigation. Supplementum 1990;202():159.
1989: Leemans R; Remaut E; Fiers W
Correlation between temperature-dependent cytoplasmic solubility and periplasmic export of a heterologous protein in Escherichia coli.
Gene 1989;85(1):99-108.
1989: Beyaert R; Vanhaesebroeck B; Suffys P; Van Roy F; Fiers W
Lithium chloride potentiates tumor necrosis factor-mediated cytotoxicity in vitro and in vivo.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(23):9494-8.
1989: Van Roy F M; Coopman P; Suffys P; Liebaut G; Vleminckx K; Gao J; Dragonetti C H; Fiers W; Mareel M M
Effect of oncogene transfection or passage in vivo on malignant phenotypes of rat2 cells.
Anticancer research 1989;9(6):1553-64.
1989: Everaerdt B; Brouckaert P; Shaw A; Fiers W
Four different interleukin-1 species sensitize to the lethal action of tumour necrosis factor.
Biochemical and biophysical research communications 1989;163(1):378-85.
1989: Vanhaesebroeck B; Grooten J; Fiers W
An ongoing in vivo immune response affects the abundancy and differentiation of lymphokine-activated killer cell precursors, but does not influence their broad spectrum target reactivity.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(4):1396-402.
1989: Jayaram B; Devos R; Guisez Y; Fiers W
Purification of human interleukin-4 produced in Escherichia coli.
Gene 1989;79(2):345-54.
1989: Grooten J; Fiers W
Acquisition by the murine host of responsiveness toward various neoplastic cell lines, but not toward self, through adoptive transfer of a helper T-lymphocyte clone with antiself specificity.
Cancer research 1989;49(14):3872-8.
1989: Brouckaert P; Spriggs D R; Demetri G; Kufe D W; Fiers W
Circulating interleukin 6 during a continuous infusion of tumor necrosis factor and interferon gamma.
The Journal of experimental medicine 1989;169(6):2257-62.
1989: Unkles S E; Campbell E I; Carrez D; Grieve C; Contreras R; Fiers W; Van den Hondel C A; Kinghorn J R
Transformation of Aspergillus niger with the homologous nitrate reductase gene.
Gene 1989;78(1):157-66.
1989: Brouckaert P G; Everaerdt B; Libert C; Takahashi N; Fiers W
Species specificity and involvement of other cytokines in endotoxic shock action of recombinant tumour necrosis factor in mice.
Agents and actions 1989;26(1-2):196-8.
1989: Suffys P; Beyaert R; Van Roy F; Fiers W
TNF in combination with interferon-gamma is cytotoxic to normal, untransformed mouse and rat embryo fibroblast-like cells.
Anticancer research 1989;9(1):167-71.
1989: Brouckaert P G; Libert C; Everaerdt B; Takahashi N; Fiers W
A role for interleukin 1 in the in vivo actions of tumor necrosis factor.
Lymphokine research 1989;8(3):269-74.
1989: Fiers W; Balkwill F R
Future prospects and problems.
Cancer surveys 1989;8(4):921-7.
1988: Suffys P; Beyaert R; Van Roy F; Fiers W
Involvement of a serine protease in tumour-necrosis-factor-mediated cytotoxicity.
European journal of biochemistry / FEBS 1988;178(1):257-65.
1988: Van Ostade X; Tavernier J; Fiers W
Two conserved tryptophan residues of tumor necrosis factor and lymphotoxin are not involved in the biological activity.
FEBS letters 1988;238(2):347-52.
1988: Mareel M; Dragonetti C; Tavernier J; Fiers W
Tumor-selective cytotoxic effects of murine tumor necrosis factor (TNF) and interferon-gamma (IFN-gamma) in organ culture of B16 melanoma cells and heart tissue.
International journal of cancer. Journal international du cancer 1988;42(3):470-3.
1988: De Waele P; Feys V; Van de Voorde A; Molemans F; Fiers W
Expression in non-lymphoid cells of mouse recombinant immunoglobulin directed against the tumour marker human placental alkaline phosphatase.
European journal of biochemistry / FEBS 1988;176(2):287-95.
1988: Vandenabeele P; Jayaram B; Devos R; Shaw A; Fiers W
Interleukin 1 alpha acts as an autocrine growth factor for RPMI 1788, an Epstein-Barr virus-transformed human B cell line.
European journal of immunology 1988;18(7):1027-31.
1988: Huylebroeck D; Maertens G; Verhoeyen M; Lopez C; Raeymakers A; Jou W M; Fiers W
High-level transient expression of influenza virus proteins from a series of SV40 late and early replacement vectors.
Gene 1988;66(2):163-81.
1988: Suffys P; Van Roy F; Fiers W
Tumor necrosis factor and interleukin 1 activate phospholipase in rat chondrocytes.
FEBS letters 1988;232(1):24-8.
1988: Fiers W; Beyaert R; Brouckaert P; Everaerdt B; Haegeman C; Suffys P; Tavernier J; Vanhaesebroeck B
TNF: its potential as an antitumour agent.
Developments in biological standardization 1988;69():143-51.
1988: Feys V; De Waele P; Van de Voorde A; Casneuf P; Fiers W
Expression of functional mouse antibodies directed against the tumour marker human placental alkaline phosphatase in non-lymphoid cells.
International journal of cancer. Supplement = Journal international du cancer. Supplement 1988;2():26-7.
1987: Fiers W; Beyaert R; Brouckaert P; Everaerdt B; Haegeman G; Suffys P; Tavernier J; Vandenabeele P; Vanhaesebroeck B; Van Ostade X
Gene cloning and structure--function relationship of cytokines such as TNF and interleukins.
Immunology letters 1987;16(3-4):219-26.
1987: Suffys P; Beyaert R; Van Roy F; Fiers W
Reduced tumour necrosis factor-induced cytotoxicity by inhibitors of the arachidonic acid metabolism.
Biochemical and biophysical research communications 1987;149(2):735-43.
1987: Plaetinck G; Declercq W; Tavernier J; Nabholz M; Fiers W
Recombinant tumor necrosis factor can induce interleukin 2 receptor expression and cytolytic activity in a rat x mouse T cell hybrid.
European journal of immunology 1987;17(12):1835-8.
1987: Fiers W; Beyaert R; Brouckaert P; Everaert B; Suffys P; Tavernier J; Van Haesebroeck B; Van Roy F
Tumor necrosis factor: a potential antitumor agent?
Journal of interferon research 1987;7(5):627-34.
1987: Gao J; Van Roy F; Messiaen L; Cosaert J; Liebaut G; Coopman P; Fiers W; Mareel M
Pathology of tumours produced in syngeneic Fischer rats by fibroblast-like cells before and after transfection with oncogenes.
Pathology, research and practice 1987;182(1):48-57.
1987: Fiers W; Brouckaert P; Goldberg A L; Kettelhut I; Suffys P; Tavernier J; Vanhaesebroeck B; Van Roy F
Structure-function relationship of tumour necrosis factor and its mechanism of action.
Ciba Foundation symposium 1987;131():109-23.
1986: Van Roy F M; Messiaen L; Liebaut G; Gao J; Dragonetti C H; Fiers W C; Mareel M M
Invasiveness and metastatic capability of rat fibroblast-like cells before and after transfection with immortalizing and transforming genes.
Cancer research 1986;46(9):4787-95.
1986: Stanssens P; Remaut E; Fiers W
Inefficient translation initiation causes premature transcription termination in the lacZ gene.
Cell 1986;44(5):711-8.
1986: Fiers W; Brouckaert P; Devos R; Fransen L; Leroux-Roels G; Remaut E; Suffys P; Tavernier J; Van der Heyden J; Van Roy F
Lymphokines and monokines in anti-cancer therapy.
Cold Spring Harbor symposia on quantitative biology 1986;51 Pt 1():587-95.
1986: Remaut E; Stanssens P; Simons G; Fiers W
Use of the phage lambda PL promoter for high-level expression of human interferons in Escherichia coli.
Methods in enzymology 1986;119():366-75.
1985: Devos R; Jayaram B; Vandenabeele P; Fiers W
Recombinant interleukin 2 induces immunoglobulin secretion in Staphylococcus aureus Cowan strain I activated human B-cells.
Immunology letters 1985;11(2):101-5.
1985: Stanssens P; Remaut E; Fiers W
Alterations upstream from the Shine-Dalgarno region and their effect on bacterial gene expression.
Gene 1985;36(3):211-23.
1983: Verhoeyen M; Van Rompuy L; Jou W M; Huylebroeck D; Fiers W
Complete nucleotide sequence of the influenza B/Singapore/222/79 virus hemagglutinin gene and comparison with the B/Lee/40 hemagglutinin.
Nucleic acids research 1983;11(14):4703-12.
1983: Remaut E; Stanssens P; Fiers W
Inducible high level synthesis of mature human fibroblast interferon in Escherichia coli.
Nucleic acids research 1983;11(14):4677-88.
1983: Devos R; Plaetinck G; Cheroutre H; Simons G; Degrave W; Tavernier J; Remaut E; Fiers W
Molecular cloning of human interleukin 2 cDNA and its expression in E. coli.
Nucleic acids research 1983;11(13):4307-23.
1983: Gheysen D; van de Voorde A; Contreras R; Vanderheyden J; Duerinck F; Fiers W
Simian virus 40 mutants carrying extensive deletions in the 72-base-pair repeat region.
Journal of virology 1983;47(1):1-14.
1983: Tavernier J; Gheysen D; Duerinck F; Van der Heyden J; Fiers W
Deletion mapping of the inducible promoter of human IFN-beta gene.
Nature 1983;301(5901):634-6.
1983: Degrave W; Tavernier J; Duerinck F; Plaetinck G; Devos R; Fiers W
Cloning and structure of the human interleukin 2 chromosomal gene.
The EMBO journal 1983;2(12):2349-53.
1982: Contreras R; Gheysen D; Knowland J; van de Voorde A; Fiers W
Evidence for the direct involvement of DNA replication origin in synthesis of late SV40 RNA.
Nature 1982;300(5892):500-5.
1982: Contreras R; Cheroutre H; Degrave W; Fiers W
Simple, efficient in vitro synthesis of capped RNA useful for direct expression of cloned eukaryotic genes.
Nucleic acids research 1982;10(20):6353-62.
1982: Van Rompuy L; Jou W M; Huylebroeck D; Fiers W
Complete nucleotide sequence of a human influenza neuraminidase gene of subtype N2 (A/Victoria/3/75).
Journal of molecular biology 1982;161(1):1-11.
1982: Fiers W; Remaut E; Devos R; Cheroutre H; Contreras R; Gheysen D; Degrave W; Stanssens P; Tavernier J; Taya Y; Content J
The human fibroblast and human immune interferon genes and their expression in homologous and heterologous cells.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1982;299(1094):29-38.
1982: Devos R; Cheroutre H; Taya Y; Degrave W; Van Heuverswyn H; Fiers W
Molecular cloning of human immune interferon cDNA and its expression in eukaryotic cells.
Nucleic acids research 1982;10(8):2487-501.
1982: Fiers W; Degrave W; Derynck R; Devos R; Gheysen D; Remaut E; Stanssens P; Tavernier J; Content J; De Clercq E
The human fibroblast interferon gene(s) and their expression in heterologous cells.
Princess Takamatsu symposia 1982;12():227-36.
1982: Taya Y; Devos R; Tavernier J; Cheroutre H; Engler G; Fiers W
Cloning and structure of the human immune interferon-gamma chromosomal gene.
The EMBO journal 1982;1(8):953-8.
1982: Devos R; Cheroutre H; Taya Y; Fiers W
Isolation and characterization of IFN-gamma mRNA derived from mitogen-induced human splenocytes.
Journal of interferon research 1982;2(3):409-20.
1981: Derynck R; Devos R; Remaut E; Saman E; Stanssens P; Tavernier J; Volckaert G; Content J; De Clercq E; Fiers W
Isolation and characterization of a human fibroblast interferon gene and its expression in Escherichia coli.
Reviews of infectious diseases 1981;3(6):1186-95.
1981: Remaut E; Stanssens P; Fiers W
Plasmid vectors for high-efficiency expression controlled by the PL promoter of coliphage lambda.
Gene 1981;15(1):81-93.
1981: Fang R; Min Jou W; Huylebroeck D; Devos R; Fiers W
Complete structure of A/duck/Ukraine/63 influenza hemagglutinin gene: animal virus as progenitor of human H3 Hong Kong 1968 influenza hemagglutinin.
Cell 1981;25(2):315-23.
1981: Contreras R; Cheroutre H; Fiers W
A simple apparatus for injection of nanoliter quantities into Xenopus laevis oocytes.
Analytical biochemistry 1981;113(1):185-7.
1981: Van Rompuy L; Min Jou W; Huylebroeck D; Devos R; Fiers W
Complete nucleotide sequence of the nucleoprotein gene from the human influenza strain A/PR/8/34 (HON1).
European journal of biochemistry / FEBS 1981;116(2):347-53.
1980: Derynck R; Remaut E; Saman E; Stanssens P; De Clercq E; Content J; Fiers W
Expression of human fibroblast interferon gene in Escherichia coli.
Nature 1980;287(5779):193-7.
1980: Verhoeyen M; Fang R; Jou W M; Devos R; Huylebroeck D; Saman E; Fiers W
Antigenic drift between the haemagglutinin of the Hong Kong influenza strains A/Aichi/2/68 and A/Victoria/3/75.
Nature 1980;286(5775):771-6.
1980: Jou W M; Verhoeyen M; Devos R; Saman E; Fang R; Huylebroeck D; Fiers W; Threlfall G; Barber C; Carey N; Emtage S
Complete structure of the hemagglutinin gene from the human influenza A/Victoria/3/75 (H3N2) strain as determined from cloned DNA.
Cell 1980;19(3):683-96.

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