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Guido Filacchioni

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Lucia Squarcialupi; Katia Varani; Flavia Varano; Fabrizio Vincenzi; Pier Andrea Borea; Daniela Catarzi; Antonella Ciancetta; Vittoria Colotta; Carmen Corciulo; Lorenzo Di Cesare Mannelli; Guido Filacchioni; Carla Ghelardini; Stefano Moro
2-Arylpyrazolo[4,3-d]pyrimidin-7-amino derivatives as new potent and selective human A3 Adenosine receptor antagonists. Molecular modeling studies and pharmacological evaluation.
Daniela Catarzi; Vittoria Colotta; Pier Andrea Borea; Diego Dal Ben; Guido Filacchioni; Catia Lambertucci; Daniela Poli; Lucia Squarcialupi; Flavia Varano; Katia Varani; Fabrizio Vincenzi; Gloria Cristalli
Pyrazolo[1,5-c]quinazoline derivatives and their simplified analogues as adenosine receptor antagonists: synthesis, structure-affinity relationships and molecular modeling studies.
Ombretta Lenzi; Lucia Squarcialupi; Katia Varani; Flavia Varano; Fabrizio Vincenzi; Diego Dal Ben; Pier Andrea Borea; Daniela Catarzi; Vittoria Colotta; Guido Filacchioni; Catia Lambertucci; Gloria Cristalli
Synthesis, structure-affinity relationships, and molecular modeling studies of novel pyrazolo[3,4-c]quinoline derivatives as adenosine receptor antagonists.

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All Publications

2013: Lucia Squarcialupi; Katia Varani; Flavia Varano; Fabrizio Vincenzi; Pier Andrea Borea; Daniela Catarzi; Antonella Ciancetta; Vittoria Colotta; Carmen Corciulo; Lorenzo Di Cesare Mannelli; Guido Filacchioni; Carla Ghelardini; Stefano Moro
2-Arylpyrazolo[4,3-d]pyrimidin-7-amino derivatives as new potent and selective human A3 Adenosine receptor antagonists. Molecular modeling studies and pharmacological evaluation.
Journal of medicinal chemistry 2013;56(6):2256-69.
2013: Daniela Catarzi; Vittoria Colotta; Pier Andrea Borea; Diego Dal Ben; Guido Filacchioni; Catia Lambertucci; Daniela Poli; Lucia Squarcialupi; Flavia Varano; Katia Varani; Fabrizio Vincenzi; Gloria Cristalli
Pyrazolo[1,5-c]quinazoline derivatives and their simplified analogues as adenosine receptor antagonists: synthesis, structure-affinity relationships and molecular modeling studies.
Bioorganic & medicinal chemistry 2013;21(1):283-94.
2011: Ombretta Lenzi; Lucia Squarcialupi; Katia Varani; Flavia Varano; Fabrizio Vincenzi; Diego Dal Ben; Pier Andrea Borea; Daniela Catarzi; Vittoria Colotta; Guido Filacchioni; Catia Lambertucci; Gloria Cristalli
Synthesis, structure-affinity relationships, and molecular modeling studies of novel pyrazolo[3,4-c]quinoline derivatives as adenosine receptor antagonists.
Bioorganic & medicinal chemistry 2011;19(12):3757-68.
2011: Daniela Poli; Daniela Catarzi; Vittoria Colotta; Flavia Varano; Guido Filacchioni; Simona Daniele; Letizia Trincavelli; Claudia Martini; Silvia Paoletta; Stefano Moro
The identification of the 2-phenylphthalazin-1(2H)-one scaffold as a new decorable core skeleton for the design of potent and selective human A3 adenosine receptor antagonists.
Journal of medicinal chemistry 2011;54(7):2102-13.
2010: Daniela Catarzi; Ombretta Lenzi; Vittoria Colotta; Flavia Varano; Daniela Poli; Guido Filacchioni; Kurt Lingenhöhl; Silvio Ofner
Pharmacological characterization of some selected 4,5-dihydro-4-oxo-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylates and 3-hydroxyquinazoline-2,4-diones as (S)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)-propionic acid receptor antagonists.
Chemical & pharmaceutical bulletin 2010;58(7):908-11.
2009: Ombretta Lenzi; Vittoria Colotta; Daniela Catarzi; Flavia Varano; Daniela Poli; Guido Filacchioni; Katia Varani; Fabrizio Vincenzi; Pier Andrea Borea; Silvia Paoletta; Erika Morizzo; Stefano Moro
2-Phenylpyrazolo[4,3-d]pyrimidin-7-one as a new scaffold to obtain potent and selective human A3 adenosine receptor antagonists: new insights into the receptor-antagonist recognition.
Journal of medicinal chemistry 2009;52(23):7640-52.
2009: Flavia Varano; Daniela Catarzi; Vittoria Colotta; Daniela Poli; Guido Filacchioni; Alessandro Galli; Chiara Costagli
Synthesis and biological evaluation of a new set of pyrazolo[1,5-c]quinazolines as glycine/N-methyl-D-aspartic acid receptor antagonists.
Chemical & pharmaceutical bulletin 2009;57(8):826-9.
2009: Vittoria Colotta; Ombretta Lenzi; Daniela Catarzi; Flavia Varano; Guido Filacchioni; Claudia Martini; Letizia Trincavelli; Osele Ciampi; Anna Maria Pugliese; Chiara Traini; Felicita Pedata; Erika Morizzo; Stefano Moro
Pyrido[2,3-e]-1,2,4-triazolo[4,3-a]pyrazin-1-one as a new scaffold to develop potent and selective human A3 adenosine receptor antagonists. Synthesis, pharmacological evaluation, and ligand-receptor modeling studies.
Journal of medicinal chemistry 2009;52(8):2407-19.
2008: Daniela Catarzi; Vittoria Colotta; Flavia Varano; Guido Filacchioni; Paola Gratteri; Jacopo Sgrignani; Alessandro Galli; Chiara Costagli
Synthesis and biological evaluation of novel 9-heteroaryl substituted 7-chloro-4,5-dihydro-4-oxo-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylates (TQX) as (R,S)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid (AMPA) receptor antagonists.
Chemical & pharmaceutical bulletin 2008;56(8):1085-91.
2008: Vittoria Colotta; Daniela Catarzi; Flavia Varano; Ombretta Lenzi; Guido Filacchioni; Claudia Martini; Letizia Trincavelli; Osele Ciampi; Chiara Traini; Anna Maria Pugliese; Felicita Pedata; Erika Morizzo; Stefano Moro
Synthesis, ligand-receptor modeling studies and pharmacological evaluation of novel 4-modified-2-aryl-1,2,4-triazolo[4,3-a]quinoxalin-1-one derivatives as potent and selective human A3 adenosine receptor antagonists.
Bioorganic & medicinal chemistry 2008;16(11):6086-102.
2008: Flavia Varano; Daniela Catarzi; Vittoria Colotta; Ombretta Lenzi; Guido Filacchioni; Alessandro Galli; Chiara Costagli
Novel AMPA and kainate receptor antagonists containing the pyrazolo[1,5-c]quinazoline ring system: Synthesis and structure-activity relationships.
Bioorganic & medicinal chemistry 2008;16(5):2617-26.
2007: Erika Morizzo; Francesca Capelli; Ombretta Lenzi; Daniela Catarzi; Flavia Varano; Guido Filacchioni; Fabrizio Vincenzi; Katia Varani; Pier Andrea Borea; Vittoria Colotta; Stefano Moro
Scouting human A3 adenosine receptor antagonist binding mode using a molecular simplification approach: from triazoloquinoxaline to a pyrimidine skeleton as a key study.
Journal of medicinal chemistry 2007;50(26):6596-606.
2007: Magdalena Bacilieri; Flavia Varano; Francesca Deflorian; M Marini; Daniela Catarzi; Vittoria Colotta; Guido Filacchioni; A Galli; Chiara Costagli; C Kaseda; Stefano Moro
Tandem 3D-QSARs approach as a valuable tool to predict binding affinity data: design of new Gly/NMDA receptor antagonists as a key study.
Journal of chemical information and modeling 2007;47(5):1913-22.
2007: Vittoria Colotta; Daniela Catarzi; Flavia Varano; Francesca Capelli; Ombretta Lenzi; Guido Filacchioni; Claudia Martini; Letizia Trincavelli; Osele Ciampi; Anna Maria Pugliese; Felicita Pedata; Andrea Schiesaro; Erika Morizzo; Stefano Moro
New 2-arylpyrazolo[3,4-c]quinoline derivatives as potent and selective human A3 adenosine receptor antagonists. Synthesis, pharmacological evaluation, and ligand-receptor modeling studies.
Journal of medicinal chemistry 2007;50(17):4061-74.
2006: Vittoria Colotta; Daniela Catarzi; Flavia Varano; Ombretta Lenzi; Guido Filacchioni; Chiara Costagli; Alessandro Galli; Carla Ghelardini; Nicoletta Galeotti; Paola Gratteri; Jacopo Sgrignani; Francesca Deflorian; Stefano Moro
Structural investigation of the 7-chloro-3-hydroxy-1H-quinazoline-2,4-dione scaffold to obtain AMPA and kainate receptor selective antagonists. Synthesis, pharmacological, and molecular modeling studies.
Journal of medicinal chemistry 2006;49(20):6015-26.
2006: Ombretta Lenzi; Vittoria Colotta; Daniela Catarzi; Flavia Varano; Guido Filacchioni; Claudia Martini; Letizia Trincavelli; Osele Ciampi; Katia Varani; Federico Marighetti; Erika Morizzo; Stefano Moro
4-amido-2-aryl-1,2,4-triazolo[4,3-a]quinoxalin-1-ones as new potent and selective human A3 adenosine receptor antagonists. synthesis, pharmacological evaluation, and ligand-receptor modeling studies.
Journal of medicinal chemistry 2006;49(13):3916-25.
2005: Daniela Catarzi; Vittoria Colotta; Flavia Varano; Ombretta Lenzi; Guido Filacchioni; Letizia Trincavelli; Claudia Martini; Christian Montopoli; Stefano Moro
1,2,4-Triazolo[1,5-a]quinoxaline as a versatile tool for the design of selective human A3 adenosine receptor antagonists: synthesis, biological evaluation, and molecular modeling studies of 2-(hetero)aryl- and 2-carboxy-substituted derivatives.
Journal of medicinal chemistry 2005;48(25):7932-45.
2005: Flavia Varano; Daniela Catarzi; Vittoria Colotta; Francesca Romana Calabri; Ombretta Lenzi; Guido Filacchioni; Alessandro Galli; Chiara Costagli; Francesca Deflorian; Stefano Moro
1-Substituted pyrazolo[1,5-c]quinazolines as novel Gly/NMDA receptor antagonists: synthesis, biological evaluation, and molecular modeling study.
Bioorganic & medicinal chemistry 2005;13(19):5536-49.
2005: Francesca Romana Calabri; Vittoria Colotta; Daniela Catarzi; Flavia Varano; Ombretta Lenzi; Guido Filacchioni; Chiara Costagli; Alessandro Galli
Synthesis and pharmacological studies at the Gly/NMDA, AMPA and Kainate receptors of new oxazolo[4,5-c]quinolin-4-one derivatives bearing different substituents at position-2 and on the fused benzo ring.
European journal of medicinal chemistry 2005;40(9):897-907.
2005: Daniela Catarzi; Vittoria Colotta; Flavia Varano; Francesca Romana Calabri; Ombretta Lenzi; Guido Filacchioni; Letizia Trincavelli; Claudia Martini; Andrea Tralli; Christian Montopoli; Stefano Moro
2-aryl-8-chloro-1,2,4-triazolo[1,5-a]quinoxalin-4-amines as highly potent A1 and A3 adenosine receptor antagonists.
Bioorganic & medicinal chemistry 2005;13(3):705-15.
2004: Vittoria Colotta; Daniela Catarzi; Flavia Varano; Francesca Romana Calabri; Ombretta Lenzi; Guido Filacchioni; Claudia Martini; Letizia Trincavelli; Francesca Deflorian; Stefano Moro
1,2,4-triazolo[4,3-a]quinoxalin-1-one moiety as an attractive scaffold to develop new potent and selective human A3 adenosine receptor antagonists: synthesis, pharmacological, and ligand-receptor modeling studies.
Journal of medicinal chemistry 2004;47(14):3580-90.
2004: Vittoria Colotta; Daniela Catarzi; Flavia Varano; Francesca Romana Calabri; Guido Filacchioni; Chiara Costagli; Alessandro Galli
3-hydroxy-quinazoline-2,4-dione as a useful scaffold to obtain selective Gly/NMDA and AMPA receptor antagonists.
Bioorganic & medicinal chemistry letters 2004;14(9):2345-9.
2004: Daniela Catarzi; Vittoria Colotta; Flavia Varano; Guido Filacchioni; Claudia Martini; Letizia Trincavelli; Antonio Lucacchini
1,2,4-Triazolo[1,5-a]quinoxaline derivatives: synthesis and biological evaluation as adenosine receptor antagonists.
Farmaco (Società chimica italiana : 1989) 2004;59(2):71-81.
2004: Vittoria Colotta; Daniela Catarzi; Flavia Varano; Guido Filacchioni; Claudia Martini; Letizia Trincavelli; Antonio Lucacchini; Vittoria Colotta
Synthesis and structure-activity relationships of 4-cycloalkylamino-1, 2, 4-triazolo[4, 3-a]quinoxalin-1- one derivatives as A1 and A3 adenosine receptor antagonists.
Archiv der Pharmazie 2004;337(1):35-41.
2004: Daniela Catarzi; Vittoria Colotta; Flavia Varano; Francesca Romana Calabri; Guido Filacchioni; Alessandro Galli; Chiara Costagli; Vincenzo Carlà
Synthesis and biological evaluation of analogues of 7-chloro-4,5-dihydro-4- oxo-8-(1,2,4-triazol-4-yl)-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylic acid (TQX-173) as novel selective AMPA receptor antagonists.
Journal of medicinal chemistry 2004;47(1):262-72.
2003: Vittoria Colotta; Daniela Catarzi; Flavia Varano; Guido Filacchioni; Claudia Martini; Letizia Trincavelli; Antonio Lucacchini
Synthesis of 4-amino-6-(hetero)arylalkylamino-1,2,4-triazolo[4,3-a]quinoxalin-1-one derivatives as potent A(2A) adenosine receptor antagonists.
Bioorganic & medicinal chemistry 2003;11(24):5509-18.
2003: Vittoria Colotta; Daniela Catarzi; Flavia Varano; Guido Filacchioni; Claudia Martini; Letizia Trincavelli; Antonio Lucacchini
Synthesis and structure-activity relationships of a new set of 1,2,4-triazolo[4,3-a]quinoxalin-1-one derivatives as adenosine receptor antagonists.
Bioorganic & medicinal chemistry 2003;11(16):3541-50.
2002: Flavia Varano; Daniela Catarzi; Vittoria Colotta; Guido Filacchioni; Alessandro Galli; Chiara Costagli; Vincenzo Carlà
Synthesis and biological evaluation of a new set of pyrazolo[1,5-c]quinazoline-2-carboxylates as novel excitatory amino acid antagonists.
Journal of medicinal chemistry 2002;45(5):1035-44.
2001: Daniela Catarzi; Vittoria Colotta; Flavia Varano; Guido Filacchioni; Alessandro Galli; Chiara Costagli; Vincenzo Carlà
Synthesis, ionotropic glutamate receptor binding affinity, and structure-activity relationships of a new set of 4,5-dihydro-8-heteroaryl-4-oxo-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylates analogues of TQX-173.
Journal of medicinal chemistry 2001;44(19):3157-65.
2001: Flavia Varano; Daniela Catarzi; Vittoria Colotta; L Cecchi; Guido Filacchioni; Alessandro Galli; Chiara Costagli
Synthesis of a set of ethyl 1-carbamoyl-3-oxoquinoxaline-2-carboxylates and of their constrained analogue imidazo.
European journal of medicinal chemistry 2001;36(2):203-9.
2000: Daniela Catarzi; Vittoria Colotta; Flavia Varano; L Cecchi; Guido Filacchioni; Alessandro Galli; Chiara Costagli; Vincenzo Carlà
7-Chloro-4,5-dihydro-8-(1,2,4-triazol-4-yl)-4-oxo-1,2,4-triazolo[1, 5-a]quinoxaline-2- carboxylates as novel highly selective AMPA receptor antagonists.
Journal of medicinal chemistry 2000;43(21):3824-6.
2000: Vittoria Colotta; Daniela Catarzi; Flavia Varano; L Cecchi; Guido Filacchioni; Claudia Martini; Letizia Trincavelli; Antonio Lucacchini
Synthesis and structure-activity relationships of a new set of 2-arylpyrazolo[3,4-c]quinoline derivatives as adenosine receptor antagonists.
Journal of medicinal chemistry 2000;43(16):3118-24.
2000: Vittoria Colotta; Daniela Catarzi; Flavia Varano; L Cecchi; Guido Filacchioni; Claudia Martini; Letizia Trincavelli; Antonio Lucacchini
1,2,4-Triazolo[4,3-a]quinoxalin-1-one: a versatile tool for the synthesis of potent and selective adenosine receptor antagonists.
Journal of medicinal chemistry 2000;43(6):1158-64.
1999: Daniela Catarzi; Vittoria Colotta; Flavia Varano; L Cecchi; Guido Filacchioni; Alessandro Galli; Chiara Costagli
4,5-Dihydro-1,2,4-triazolo[1,5-a]quinoxalin-4-ones: excitatory amino acid antagonists with combined glycine/NMDA and AMPA receptor affinity.
Journal of medicinal chemistry 1999;42(13):2478-84.
1999: Flavia Varano; Daniela Catarzi; Vittoria Colotta; L Cecchi; Guido Filacchioni; Alessandro Galli; Chiara Costagli
Synthesis, glycine/NMDA and AMPA binding activity of some new 2,5,6-trioxopyrazino[1,2,3-de]quinoxalines and of their restricted analogs 2,5-dioxo- and 4,5-dioxoimidazo[1,5,4-de]quinoxalines.
Archiv der Pharmazie 1999;332(6):201-7.
1999: Vittoria Colotta; Daniela Catarzi; Flavia Varano; L Cecchi; Guido Filacchioni; Claudia Martini; Letizia Trincavelli; Antonio Lucacchini
4-Amino-6-benzylamino-1,2-dihydro-2-phenyl-1,2,4-triazolo [4,3-alpha]-quinoxalin-1-one: a new A2A adenosine receptor antagonist with high selectivity versus A1 receptors.
Archiv der Pharmazie 1999;332(2):39-41.
1998: Flavia Varano; Daniela Catarzi; Vittoria Colotta; Guido Filacchioni; L Cecchi; Alessandro Galli; Chiara Costagli
Synthesis of 2-substituted-6,8-dichloro-3,4-dihydro-3-oxo-2H-1,4-benzothiazine-1,1-d ioxides and -1-oxides as glycine-NMDA receptor antagonists.
Farmaco (Società chimica italiana : 1989) 1998;53(12):752-7.
1998: Vittoria Colotta; Daniela Catarzi; Flavia Varano; Fabrizio Melani; Guido Filacchioni; L Cecchi; Letizia Trincavelli; Claudia Martini; Antonio Lucacchini
Synthesis and A1 and A2A adenosine binding activity of some pyrano[2,3-c]pyrazol-4-ones.
Farmaco (Società chimica italiana : 1989) 1998;53(3):189-96.
1997: Vittoria Colotta; Daniela Catarzi; Flavia Varano; L Cecchi; Guido Filacchioni; Alessandro Galli; Chiara Costagli
Tricyclic heteroaromatic systems. 1,2,4-triazolo[4,3-a]quinoxalines and 1,2,4-Triazino[4,3-a]quinoxalines: synthesis and central benzodiazepine receptor activity.
Archiv der Pharmazie 1997;330(12):387-91.
1997: Daniela Catarzi; Vittoria Colotta; Flavia Varano; L Cecchi; Guido Filacchioni; Alessandro Galli; Chiara Costagli
Tricyclic heteroaromatic systems. Pyrazolo[3,4-c]quinolin-4-ones and pyrazolo[3,4-c]quinoline-1,4-diones: synthesis and benzodiazepine receptor activity.
Archiv der Pharmazie 1997;330(12):383-6.
1997: Vittoria Colotta; Daniela Catarzi; Flavia Varano; L Cecchi; Guido Filacchioni; Alessandro Galli; Chiara Costagli
Synthesis and biological evaluation of a series of quinazoline-2-carboxylic acids and quinazoline-2,4-diones as glycine-NMDA antagonists: a pharmacophore model based approach.
Archiv der Pharmazie 1997;330(5):129-34.
1997: Flavia Varano; Daniela Catarzi; Vittoria Colotta; L Cecchi; Guido Filacchioni; Alessandro Galli; Chiara Costagli
Tricyclic heteroaromatic systems. 3-substituted 1,2,3,5,6,7-hexahydro-2,5,6-trioxopyrazino[1,2,3-de]-quinoxalines as novel antagonists at the glycine-NMDA site.
Farmaco (Società chimica italiana : 1989) 1997;52(3):179-82.
1996: Flavia Varano; Daniela Catarzi; Vittoria Colotta; L Cecchi; Guido Filacchioni; Alessandro Galli; Chiara Costagli
Structure-activity relationship studies of novel pyrazolo[1,5-c][1,3]benzoxazines: synthesis and benzodiazepine receptor affinity.
Archiv der Pharmazie 1996;329(12):529-34.
1996: Vittoria Colotta; Daniela Catarzi; Flavia Varano; Guido Filacchioni; L Cecchi; Alessandro Galli; Chiara Costagli
Synthesis and binding activity of some pyrazolo[1,5-c]quinazolines as tools to verify an optional binding site of a benzodiazepine receptor ligand.
Journal of medicinal chemistry 1996;39(15):2915-21.
1995: Daniela Catarzi; L Cecchi; Vittoria Colotta; Guido Filacchioni; Flavia Varano; Claudia Martini; L Giousti; Antonio Lucacchini
Synthesis of some 2-aryl-1,2,4-triazolo[1,5-c][1,3]benzoxazin-5-ones as tools to define the essential pharmacophoric descriptors of a benzodiazepine receptor ligand.
Journal of medicinal chemistry 1995;38(12):2196-201.
1995: Daniela Catarzi; L Cecchi; Vittoria Colotta; Guido Filacchioni; Claudia Martini; P Tacchi; Antonio Lucacchini
Tricyclic heteroaromatic systems. Synthesis and A1 and A2a adenosine binding activities of some 1-aryl-1,4-dihydro-3-methyl[1]benzopyrano[2,3-c] pyrazol-4-ones, 1-aryl-4,9-dihydro-3-methyl-1H-pyrazolo[3,4-b]quinolin-4- ones, and 1-aryl-1H-imidazo[4,5-b]quinoxalines.
Journal of medicinal chemistry 1995;38(8):1330-6.
1994: Daniela Catarzi; L Cecchi; Vittoria Colotta; Fabrizio Melani; Guido Filacchioni; Claudia Martini; Laura Giusti; Antonio Lucacchini
Structure-activity relationships of 1,2,4-triazolo[1,5-a] quinoxalines and their 1-deaza analogues imidazo[1,2-a]quinoxalines at the benzodiazepine receptor.
Journal of medicinal chemistry 1994;37(18):2846-50.
1993: Daniela Catarzi; L Cecchi; Vittoria Colotta; Fabrizio Melani; Guido Filacchioni; Claudia Martini; Laura Giusti; Antonio Lucacchini
Tricyclic heteroaromatic systems 1,2,4-triazolo[1,5-a]quinoxalines: synthesis and benzodiazepine receptor activity.
Farmaco (Società chimica italiana : 1989) 1993;48(8):1065-78.
1993: Vittoria Colotta; L Cecchi; Daniela Catarzi; G Conti; Guido Filacchioni; Claudia Martini; Laura Giusti; Antonio Lucacchini
Tricyclic heteroaromatic systems pyrazolo[1,5-a]quinoxalines: synthesis and benzodiazepine receptor activity.
Farmaco (Società chimica italiana : 1989) 1993;48(8):1051-63.
1993: Daniela Catarzi; L Cecchi; Vittoria Colotta; G Conti; Fabrizio Melani; Guido Filacchioni; Claudia Martini; Laura Giusti; Antonio Lucacchini
Reaction of 1-aminophthalazines with alpha-halocarbonyl compounds: imidazo[2,1-a]phthalazines and their benzodiazepine receptor activities.
Farmaco (Società chimica italiana : 1989) 1993;48(4):447-57.
1993: Daniela Catarzi; L Cecchi; Guido Filacchioni; Alessandro Bartolini; R Carpenedo; Alessandro Galli; F Mori
Synthesis and structure-activity relationships of 1-aminophthalazinium bromides as GABAA receptor ligands.
Drug design and discovery 1993;10(1):23-34.
1993: Vittoria Colotta; L Cecchi; Daniela Catarzi; Fabrizio Melani; Guido Filacchioni; Claudia Martini; P Tacchi; Antonio Lucacchini
Novel adenosine receptor ligands: 1,3-disubstituted[1]benzopyrano[2,3-c]pyrazol-4-ones. Synthesis and structure-activity relationships.
Receptors & channels 1993;1(2):111-9.
1992: Vittoria Colotta; L Cecchi; Fabrizio Melani; Daniela Catarzi; Guido Filacchioni; Claudia Martini; Gino Giannaccini; M Tonelli; Antonio Lucacchini
Tricyclic heteroaromatic systems. Synthesis and benzodiazepine binding activity of 1-substituted-3-methyl- and 3-phenylpyrazolo[4,5-c]quinolin-4-ones.
Drug design and discovery 1992;8(4):325-39.
1991: Vittoria Colotta; L Cecchi; Fabrizio Melani; Guido Filacchioni; Claudia Martini; S Gelli; Antonio Lucacchini
Tricyclic heteroaromatic systems. Synthesis of 1,3 and 1,2 disubstituted [1]benzopyrano[4,3-b]pyrrol-4-ones and structure-activity relationships as benzodiazepine receptor ligands.
Farmaco (Società chimica italiana : 1989) 1991;46(10):1139-54.
1991: Vittoria Colotta; L Cecchi; Fabrizio Melani; Guido Filacchioni; Claudia Martini; S Gelli; Antonio Lucacchini
Tricyclic heteroaromatic systems: [1]benzopyrano-pyrazol-4-ones as benzodiazepine receptor ligands.
Journal of pharmaceutical sciences 1991;80(3):276-9.
1990: Vittoria Colotta; L Cecchi; Fabrizio Melani; Guido Filacchioni; Claudia Martini; Gino Giannaccini; Antonio Lucacchini
Tricyclic heteroaromatic systems. [1]benzopyranopyrrol-4-ones and [1]benzopyrano-1,2,3-triazol-4-ones as benzodiazepine receptor ligands. Synthesis and structure-activity relationships.
Journal of medicinal chemistry 1990;33(9):2646-51.
1989: Fabrizio Melani; L Cecchi; Vittoria Colotta; Guido Filacchioni; Claudia Martini; Gino Giannaccini; Antonio Lucacchini
Dipyrazolo[5,4-b:3',4'-d]pyridines. Synthesis, inhibition of benzodiazepine receptor binding and structure-activity relationships.
Farmaco (Società chimica italiana : 1989) 1989;44(6):585-94.
1989: L Cecchi; Vittoria Colotta; Fabrizio Melani; G Palazzino; Guido Filacchioni; Claudia Martini; Gino Giannaccini; Antonio Lucacchini
Synthesis of 1,5-diaryl-3-methyl-1H-pyrazolo[4,5-c]isoquinolines and studies of binding to specific peripheral benzodiazepine binding sites.
Journal of pharmaceutical sciences 1989;78(6):437-42.
1989: Vittoria Colotta; L Cecchi; Fabrizio Melani; G Palazzino; Guido Filacchioni; Claudia Martini; Gino Giannaccini; Antonio Lucacchini
Tricyclic heteroaromatic systems: synthesis, [3H]flunitrazepam brain membrane binding inhibition, and structure-activity relationships of 2,3-dihydro-2-aryl-4-R-[1]benzopyrano[4,3-c]pyrazole-3-ones.
Journal of pharmaceutical sciences 1989;78(3):239-42.
1988: Vittoria Colotta; L Cecchi; Guido Filacchioni; Fabrizio Melani; G Palazzino; Claudia Martini; Gino Giannaccini; Antonio Lucacchini
Synthesis, binding studies, and structure-activity relationships of 1-aryl-and 2-aryl[1]benzopyranopyrazol-4-ones, central benzodiazepine receptor ligands.
Journal of medicinal chemistry 1988;31(1):1-3.
1987: G Palazzino; L Cecchi; Fabrizio Melani; Vittoria Colotta; Guido Filacchioni; Claudia Martini; Antonio Lucacchini
1,3-Diarylpyrazolo[4,5-c]- and -[5,4-c]quinolin-4-ones. 4. Synthesis and specific inhibition of benzodiazepine receptor binding.
Journal of medicinal chemistry 1987;30(10):1737-42.
1987: L Cecchi; Vittoria Colotta; Guido Filacchioni; Fabrizio Melani; G Palazzino; Alessandro Galli
Synthesis and binding study on pyrazolo[4,5-c] [1,8]naphthyridines.
Il Farmaco; edizione scientifica 1987;42(9):671-80.
1986: Fabrizio Melani; L Cecchi; G Palazzino; Guido Filacchioni; Claudia Martini; E Pennacchi; Antonio Lucacchini
Pyrazolo[4,5-c]quinolines. 3. Synthesis, receptor binding, and 13C NMR study.
Journal of pharmaceutical sciences 1986;75(12):1175-9.
1986: G Palazzino; Fabrizio Melani; L Cecchi; Guido Filacchioni
Pyrrolnitrin analogues. XII. Synthesis and biological activity of some pyrazole carboxylic acids.
Il Farmaco; edizione scientifica 1986;41(7):566-76.
1986: Fabrizio Melani; L Cecchi; G Palazzino; Guido Filacchioni; Claudia Martini; E Pennacchi; Antonio Lucacchini
Pyrazolo[4,5-c]quinolines. 2. Synthesis and specific inhibition of benzodiazepine receptor binding.
Journal of medicinal chemistry 1986;29(2):291-5.
1985: L Cecchi; Fabrizio Melani; G Palazzino; Guido Filacchioni; Claudia Martini; E Pennacchi; Antonio Lucacchini
Synthesis and binding studies of 1-arylpyrazolo[4,5-c]- and 2-arylpyrazolo[4,3-c]quinolin-4-ones. I.
Il Farmaco; edizione scientifica 1985;40(7):509-16.
1984: L Cecchi; Fabrizio Melani; G Palazzino; Guido Filacchioni
Pyrrolnitrin analogues. X. Synthesis and biological activity of 1-chlorophenyl-3- or 5-nitrophenyl-pyrazole-4-carboxylic acids.
Il Farmaco; edizione scientifica 1984;39(11):953-62.
1984: L Cecchi; Fabrizio Melani; Guido Filacchioni; M Tredici
Synthesis and biological activity of some 3-(pyrazol-1'-yl)indazole derivatives.
Il Farmaco; edizione scientifica 1984;39(11):945-52.
1984: L Cecchi; Fabrizio Melani; G Palazzino; Guido Filacchioni; Giulio Cesare Porretta
Pyrrolnitrin analogues. IX. Synthesis and biological activity of 1-tolyl-3-nitrophenyl-5-methylpyrazole-4-carboxylic acids and 1-tolyl-3-methyl-5-nitrophenylpyrazole-4-carboxylic acids.
Il Farmaco; edizione scientifica 1984;39(10):888-900.
1983: Guido Filacchioni; Giulio Cesare Porretta; M Scalzo; M C Giardina; T Giardi
Pyrrolnitrin analogues. VIII - Synthesis and antibacterial activity of new 1,4- and 1,5-diarylpyrroles.
Il Farmaco; edizione scientifica 1983;38(9):630-9.