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David Filpula

Research Profile

Chemicals & Drugs

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Protein Engineering

Anatomy

Tumor Cell Line

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Publications

TOP 3
Lee M Greenberger; Ivan D Horak; David Filpula; Puja Sapra; Majken Westergaard; Henrik F Frydenlund; Charlotte Albaek; Henrik Schrøder; Henrik Ørum
A RNA antagonist of hypoxia-inducible factor-1alpha, EZN-2968, inhibits tumor cell growth.
David Filpula; Hong Zhao
Releasable PEGylation of proteins with customized linkers.
David Filpula
Antibody engineering and modification technologies.

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All Publications

2008: Lee M Greenberger; Ivan D Horak; David Filpula; Puja Sapra; Majken Westergaard; Henrik F Frydenlund; Charlotte Albaek; Henrik Schrøder; Henrik Ørum
A RNA antagonist of hypoxia-inducible factor-1alpha, EZN-2968, inhibits tumor cell growth.
Molecular cancer therapeutics 2008;7(11):3598-608.
2008: David Filpula; Hong Zhao
Releasable PEGylation of proteins with customized linkers.
Advanced drug delivery reviews 2008;60(1):29-49.
2007: David Filpula
Antibody engineering and modification technologies.
Biomolecular engineering 2007;24(2):201-15.
2007: David Filpula; Karen Yang; Amartya Basu; Raffit Hassan; Laiman Xiang; Zhihua Zhang; Maoliang Wang; Qing-Cheng Wang; Mitchell Ho; Richard Beers; Hong Zhao; Ping Peng; John Zhou; Xiguang Li; Gerald Petti; Ahsen Janjua; Jun Liu; Dechun Wu; Deshan Yu; Zhenfan Zhang; Clifford Longley; David FitzGerald; Robert J Kreitman; Ira Pastan
Releasable PEGylation of mesothelin targeted immunotoxin SS1P achieves single dosage complete regression of a human carcinoma in mice.
Bioconjugate chemistry 2007;18(3):773-84.
2006: Maoliang Wang; Amartya Basu; Thomas Palm; Jack Hua; Stephen Youngster; Lisa Hwang; Hsien-Ching Liu; Xiguang Li; Ping Peng; Yue Zhang; Hong Zhao; Zhihua Zhang; Clifford Longley; Mary Mehlig; Virna Borowski; Prakash Sai; Manickam Viswanathan; Eun Jang; Gerald Petti; Sam Liu; Karen Yang; David Filpula
Engineering an arginine catabolizing bioconjugate: Biochemical and pharmacological characterization of PEGylated derivatives of arginine deiminase from Mycoplasma arthritidis.
Bioconjugate chemistry 2006;17(6):1447-59.
2006: Eva-Maria Krinner; julia hepp; Patrick Hoffmann; Sandra Bruckmaier; Laetitia Petersen; Silke Petsch; Larissa Parr; Ioana Schuster; Susanne Mangold; Grit Lorenczewski; Petra Lutterbüse; Stefan Buziol; Inessa Hochheim; Jörg Volkland; Michael Mølhøj; Mirnaalini Sriskandarajah; Markus Strasser; Christian Itin; Andreas Wolf; Amartya Basu; Karen Yang; David Filpula; Poul Sørensen; Peter Kufer; Patrick A Baeuerle; Tobias Raum
A highly stable polyethylene glycol-conjugated human single-chain antibody neutralizing granulocyte-macrophage colony stimulating factor at low nanomolar concentration.
Protein engineering, design & selection : PEDS 2006;19(10):461-70.
2006: Amartya Basu; Karen Yang; Maoliang Wang; Sam Liu; Ramesh Chintala; Thomas Palm; Hong Zhao; Ping Peng; Dechun Wu; Zhenfan Zhang; Jack Hua; Ming-Ching Hsieh; John Zhou; Gerald Petti; Xiguang Li; Ahsen Janjua; Magda Mendez; Jun Liu; Clifford Longley; Zhihua Zhang; Mary Mehlig; Virna Borowski; Manickam Viswanathan; David Filpula
Structure-function engineering of interferon-beta-1b for improving stability, solubility, potency, immunogenicity, and pharmacokinetic properties by site-selective mono-PEGylation.
Bioconjugate chemistry 2006;17(3):618-30.
2006: Hong Zhao; Karen Yang; Anthony Martinez; Amartya Basu; Ramesh Chintala; Hsien-Ching Liu; Ahsen Janjua; Maoliang Wang; David Filpula
Linear and branched bicin linkers for releasable PEGylation of macromolecules: controlled release in vivo and in vitro from mono- and multi-PEGylated proteins.
Bioconjugate chemistry 2006;17(2):341-51.
2005: Deshan Yu; Ping Peng; Sonia S Dharap; Yang Wang; Mary Mehlig; Pooja Chandna; Hong Zhao; David Filpula; Karen Yang; Virna Borowski; Gerrit Borchard; Zhihua Zhang; Tamara Minko
Antitumor activity of poly(ethylene glycol)-camptothecin conjugate: the inhibition of tumor growth in vivo.
Journal of controlled release : official journal of the Controlled Release Society 2005;110(1):90-102.
2003: Karen Yang; Amartya Basu; Maoliang Wang; Ramesh Chintala; Ming-Ching Hsieh; Sam Liu; Jack Hua; Zhenfan Zhang; John Zhou; Mark Li; Hnin Phyu; Gerald Petti; Magda Mendez; haleema janjua; Ping Peng; Clifford Longley; Virna Borowski; Mary Mehlig; David Filpula
Tailoring structure-function and pharmacokinetic properties of single-chain Fv proteins by site-specific PEGylation.
Protein engineering 2003;16(10):761-70.
2003: Richard B Greenwald; Karen Yang; Hong Zhao; Charles D Conover; Stanford Lee; David Filpula
Controlled release of proteins from their poly(ethylene glycol) conjugates: drug delivery systems employing 1,6-elimination.
Bioconjugate chemistry 2003;14(2):395-403.