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Gian Maria Fimia

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Physiology

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Francesca Nazio; Mauro Piacentini; Flavie Strappazzon; Manuela Antonioli; Pamela Bielli; Matteo Bordi; Valentina Cianfanelli; Joern Dengjel; Gian Maria Fimia; Christine Gretzmeier; Francesco Cecconi
mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6.
Francesca Benato; Oliana Carnevali; Fabiola Ciccosanti; Gian Maria Fimia; G Gioacchini; Isabella Moro; Mauro Piacentini; Tatjana Skobo; Luisa Dalla Valle
Ambra1 knockdown in zebrafish leads to incomplete development due to severe defects in organogenesis.
Gian Maria Fimia; G Kroemer; Mauro Piacentini
Molecular mechanisms of selective autophagy.

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All Publications

2013: Francesca Nazio; Mauro Piacentini; Flavie Strappazzon; Manuela Antonioli; Pamela Bielli; Matteo Bordi; Valentina Cianfanelli; Joern Dengjel; Gian Maria Fimia; Christine Gretzmeier; Francesco Cecconi
mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6.
Nature cell biology 2013;15(4):406-16.
2013: Francesca Benato; Oliana Carnevali; Fabiola Ciccosanti; Gian Maria Fimia; G Gioacchini; Isabella Moro; Mauro Piacentini; Tatjana Skobo; Luisa Dalla Valle
Ambra1 knockdown in zebrafish leads to incomplete development due to severe defects in organogenesis.
Autophagy 2013;9(4):476-95.
2013: Gian Maria Fimia; G Kroemer; Mauro Piacentini
Molecular mechanisms of selective autophagy.
Cell death and differentiation 2013;20(1):1-2.
2013: Martina Severa; Pankaj Trivedi; Eleni Anastasiadou; Marco Corazzari; Gian Maria Fimia; Valérie Gafa; Elena Giacomini; Fabiana Rizzo; Alessandra Romagnoli; Eliana Marina Coccia
EBV stimulates TLR- and autophagy-dependent pathways and impairs maturation in plasmacytoid dendritic cells: implications for viral immune escape.
European journal of immunology 2013;43(1):147-58.
2012: Alessandra Romagnoli; Roxane Simeone; Roland Brosch; Marco Corazzari; Giovanni Delogu; Marilena P Etna; Laura Falasca; Gian Maria Fimia; Valérie Gafa; Elena Giacomini; Delia Goletti; Manuela Pardini; Mauro Piacentini; Maria Elena Remoli; Eliana M Coccia
ESX-1 dependent impairment of autophagic flux by Mycobacterium tuberculosis in human dendritic cells.
Autophagy 2012;8(9):1357-70.
2012: V Pagliarini; Alessandra Romagnoli; P Vandenabeele; E Wirawan; Francesco Cecconi; Fabiola Ciccosanti; Marco Corazzari; Gian Maria Fimia; Saskia Lippens; G Lisi; Mauro Piacentini
Proteolysis of Ambra1 during apoptosis has a role in the inhibition of the autophagic pro-survival response.
Cell death and differentiation 2012;19(9):1495-504.
2012: Marco Corazzari; Gian Maria Fimia; Mauro Piacentini
Dismantling the autophagic arsenal when it is time to die: concerted AMBRA1 degradation by caspases and calpains.
Autophagy 2012;8(8):1255-7.
2012: M D'Eletto; Laura Falasca; Maria Grazia Farrace; Gian Maria Fimia; G Di Giacomo; Gerry Melino; S Moreno; Roberta Nardacci; F Rossin; S Sepe; F Strappazzon; F Cecconi; Mauro Piacentini
Type 2 transglutaminase is involved in the autophagy-dependent clearance of ubiquitinated proteins.
Cell death and differentiation 2012;19(7):1228-38.
2012: Elisa Petruccioli; Mauro Piacentini; Alessandra Romagnoli; Ornella Butera; Eliana M Coccia; Marco Corazzari; Giovanni Delogu; Gian Maria Fimia; Enrico Girardi; Delia Goletti
Specific T cells restore the autophagic flux inhibited by Mycobacterium tuberculosis in human primary macrophages.
The Journal of infectious diseases 2012;205(9):1425-35.
2012: Tiziana Vescovo; Tonino Alonzi; Fabiola Ciccosanti; Marco Corazzari; Carmelo Garcia-Monzon; Giuseppe Ippolito; Oreste Lo Iacono; Roberta Nardacci; Ariel Basulto Perdomo; Mauro Piacentini; Alessandra Romagnoli; Marco Tripodi; Gian Maria Fimia
Autophagy protects cells from HCV-induced defects in lipid metabolism.
Gastroenterology 2012;142(3):644-653.e3.
2012: Ariel Basulto Perdomo; Roberto Pisa; Angela Testa; Claudio Angeletti; Giorgio Antonucci; Fabiola Ciccosanti; Marco Corazzari; Nicola Daniele; Gian Maria Fimia; Oreste Lo Iacono; Giuseppe Ippolito; Mauro Piacentini
Liver protein profiling in chronic hepatitis C: identification of potential predictive markers for interferon therapy outcome.
Journal of proteome research 2012;11(2):717-27.
2011: Jane L Armstrong; Marco Corazzari; Shaun Martin; Vittoria Pagliarini; Laura Falasca; David S Hill; Nicola Ellis; Salim Al Sabah; Christopher P F Redfern; Gian Maria Fimia; Mauro Piacentini; Penny E Lovat
Oncogenic B-RAF signaling in melanoma impairs the therapeutic advantage of autophagy inhibition.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(8):2216-26.
2011: Flavie Strappazzon; Matteo Vietri-Rudan; Silvia Campello; Francesca Nazio; Fulvio Florenzano; Gian Maria Fimia; Mauro Piacentini; Beth Levine; Francesco Cecconi
Mitochondrial BCL-2 inhibits AMBRA1-induced autophagy.
The EMBO journal 2011;30(7):1195-208.
2011: D De Zio; M Bordi; E Tino; C Lanzuolo; Elisabetta Ferraro; E Mora; Fabiola Ciccosanti; Gian Maria Fimia; V Orlando; Francesco Cecconi
The DNA repair complex Ku70/86 modulates Apaf1 expression upon DNA damage.
Cell death and differentiation 2011;18(3):516-27.
2011: Gian Maria Fimia; Sabrina Di Bartolomeo; Mauro Piacentini; Francesco Cecconi
Unleashing the Ambra1-Beclin 1 complex from dynein chains: Ulk1 sets Ambra1 free to induce autophagy.
Autophagy 2011;7(1):115-7.
2010: Sabrina Di Bartolomeo; Marco Corazzari; Francesca Nazio; Serafina Oliverio; Gaia Lisi; Manuela Antonioli; Vittoria Pagliarini; Silvia Matteoni; Claudia Fuoco; Luigi Giunta; Marcello D'Amelio; Roberta Nardacci; Alessandra Romagnoli; Mauro Piacentini; Francesco Cecconi; Gian Maria Fimia
The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy.
The Journal of cell biology 2010;191(1):155-68.
2010: Oliver Kepp; Abdelaziz Gdoura; Isabelle Martins; Theocharis Panaretakis; Frederic Schlemmer; Antoine Tesniere; Gian Maria Fimia; Fabiola Ciccosanti; Anne Burgevin; Mauro Piacentini; Paul Eggleton; Philip J Young; Laurence Zitvogel; Peter van Endert; Guido Kroemer
Lysyl tRNA synthetase is required for the translocation of calreticulin to the cell surface in immunogenic death.
Cell cycle (Georgetown, Tex.) 2010;9(15):3072-7.
2010: Carlo Rodolfo; Fabiola Ciccosanti; Giuseppina Di Giacomo; Mauro Piacentini; Gian Maria Fimia
Proteomic analysis of mitochondrial dysfunction in neurodegenerative diseases.
Expert review of proteomics 2010;7(4):519-42.
2010: Francesco Imperi; Federica Tiburzi; Gian Maria Fimia; Paolo Visca
Transcriptional control of the pvdS iron starvation sigma factor gene by the master regulator of sulfur metabolism CysB in Pseudomonas aeruginosa.
Environmental microbiology 2010;12(6):1630-42.
2010: Simona Pedrotti; Pamela Bielli; Maria Paola Paronetto; Fabiola Ciccosanti; Gian Maria Fimia; Stefan Stamm; James L Manley; Claudio Sette
The splicing regulator Sam68 binds to a novel exonic splicing silencer and functions in SMN2 alternative splicing in spinal muscular atrophy.
The EMBO journal 2010;29(7):1235-47.
2010: Carmine Mancone; Beatrice Conti; Laura Amicone; veronica bordoni; Carla Cicchini; Ludovica Calvo; Ariel Basulto Perdomo; Gian Maria Fimia; Marco Tripodi; Tonino Alonzi
Proteomic analysis reveals a major role for contact inhibition in the terminal differentiation of hepatocytes.
Journal of hepatology 2010;52(2):234-43.
2010: Fabiola Ciccosanti; Marco Corazzari; Fabio Soldani; Paola Matarrese; Vittoria Pagliarini; Valentina Iadevaia; Antonella Tinari; Mauro Zaccarelli; Jean-Luc PERFETTINI; Walter Malorni; Guido Kroemer; Andrea Antinori; Gian Maria Fimia; Mauro Piacentini
Proteomic analysis identifies prohibitin down-regulation as a crucial event in the mitochondrial damage observed in HIV-infected patients.
Antiviral therapy 2010;15(3):377-90.
2009: Manuela D'Eletto; Maria Grazia Farrace; Laura Falasca; Valentina Reali; Serafina Oliverio; Gennaro Melino; Martin Griffin; Gian Maria Fimia; Mauro Piacentini
Transglutaminase 2 is involved in autophagosome maturation.
Autophagy 2009;5(8):1145-54.
2009: Francesco Imperi; Fabiola Ciccosanti; Ariel Basulto Perdomo; Federica Tiburzi; Carmine Mancone; Tonino Alonzi; Paolo Ascenzi; Mauro Piacentini; Paolo Visca; Gian Maria Fimia
Analysis of the periplasmic proteome of Pseudomonas aeruginosa, a metabolically versatile opportunistic pathogen.
Proteomics 2009;9(7):1901-15.
2008: Theocharis Panaretakis; Nicholas Joza; Nazanine Modjtahedi; Antoine Tesniere; Ilio Vitale; M Durchschlag; Gian Maria Fimia; O Kepp; Mauro Piacentini; K-U Froehlich; Peter van Endert; Laurence Zitvogel; Frank Madeo; Guido Kroemer
The co-translocation of ERp57 and calreticulin determines the immunogenicity of cell death.
Cell death and differentiation 2008;15(9):1499-509.
2008: Barbara Fazi; Wilfried Bursch; Gian Maria Fimia; Roberta Nardacci; Mauro Piacentini; Federica Di Sano; Lucia Piredda
Fenretinide induces autophagic cell death in caspase-defective breast cancer cells.
Autophagy 2008;4(4):435-41.
2007: Francesco Cecconi; Sabrina Di Bartolomeo; Roberta Nardacci; Claudia Fuoco; Marco Corazzari; Luigi Giunta; Alessandra Romagnoli; Anastassia Stoykova; Kamal Chowdhury; Gian Maria Fimia; Mauro Piacentini
A novel role for autophagy in neurodevelopment.
Autophagy 2007;3(5):506-8.
2007: amedeo columbano; Marco Corazzari; Gian Maria Fimia; Mauro Piacentini
14th Euroconference on Apoptosis: 'death or survival? Fate in Sardinia'.
Cell death and differentiation 2007;14(8):1555-7.
2007: Gian Maria Fimia; Anastassia Stoykova; Alessandra Romagnoli; Luigi Giunta; Sabrina Di Bartolomeo; Roberta Nardacci; Marco Corazzari; Claudia Fuoco; Ahmet Ucar; Peter Schwartz; Peter Gruss; Mauro Piacentini; Kamal Chowdhury; Francesco Cecconi
Ambra1 regulates autophagy and development of the nervous system.
Nature 2007;447(7148):1121-5.
2007: Marco Corazzari; Penny E Lovat; Jane L Armstrong; Gian Maria Fimia; D S Hill; M Birch-Machin; Christopher P F Redfern; Mauro Piacentini
Targeting homeostatic mechanisms of endoplasmic reticulum stress to increase susceptibility of cancer cells to fenretinide-induced apoptosis: the role of stress proteins ERdj5 and ERp57.
British journal of cancer 2007;96(7):1062-71.
2007: Lionel Apetoh; Michel Obeid; Antoine Tesniere; François Ghiringhelli; Gian Maria Fimia; Mauro Piacentini; Guido Kroemer; Laurence Zitvogel
Immunogenic chemotherapy: discovery of a critical protein through proteomic analyses of tumor cells.
Cancer genomics & proteomics 2007;4(2):65-70.
2007: Michel Obeid; Antoine Tesniere; François Ghiringhelli; Gian Maria Fimia; Lionel Apetoh; Jean-Luc PERFETTINI; Maria Castedo; Grégoire Mignot; Theocharis Panaretakis; Noelia Casares; Didier Métivier; Nathanael Larochette; Peter van Endert; Fabiola Ciccosanti; Mauro Piacentini; Laurence Zitvogel; Guido Kroemer
Calreticulin exposure dictates the immunogenicity of cancer cell death.
Nature medicine 2007;13(1):54-61.
2007: Carmine Mancone; Laura Amicone; Gian Maria Fimia; Elena Bravo; Mauro Piacentini; Marco Tripodi; Tonino Alonzi
Proteomic analysis of human very low-density lipoprotein by two-dimensional gel electrophoresis and MALDI-TOF/TOF.
Proteomics 2007;7(1):143-54.
2007: Giuseppe Battaglia; Maria Grazia Farrace; Pier Giorgio Mastroberardino; Irene Viti; Gian Maria Fimia; Jozef Van Beeumen; Bart Devreese; Gerry Melino; Gemma Molinaro; Carla L Busceti; Francesca Biagioni; Ferdinando Nicoletti; Mauro Piacentini
Transglutaminase 2 ablation leads to defective function of mitochondrial respiratory complex I affecting neuronal vulnerability in experimental models of extrapyramidal disorders.
Journal of neurochemistry 2007;100(1):36-49.
2006: Pier Giorgio Mastroberardino; Maria Grazia Farrace; Irene Viti; Flaminia Pavone; Gian Maria Fimia; Gerry Melino; Carlo Rodolfo; Mauro Piacentini
"Tissue" transglutaminase contributes to the formation of disulphide bridges in proteins of mitochondrial respiratory complexes.
Biochimica et biophysica acta 2006;1757(9-10):1357-65.
2006: Natascia Campostrini; Danilo Marimpietri; Andrea Totolo; Carmine Mancone; Gian Maria Fimia; Mirco Ponzoni; Pier Giorgio Righetti
Proteomic analysis of anti-angiogenic effects by a combined treatment with vinblastine and rapamycin in an endothelial cell line.
Proteomics 2006;6(15):4420-31.
2006: Chiara Agrati; Tonino Alonzi; Rafaella De Santis; Concetta Castilletti; Isabella Abbate; Maria Rosaria Capobianchi; Gianpiero D'Offizi; Francesca Siepi; Gian Maria Fimia; Marco Tripodi; Fabrizio Poccia
Activation of Vgamma9Vdelta2 T cells by non-peptidic antigens induces the inhibition of subgenomic HCV replication.
International immunology 2006;18(1):11-8.
2004: Carlo Rodolfo; Elisabetta Mormone; Paola Matarrese; Fabiola Ciccosanti; Maria Grazia Farrace; Elvira Garofano; Lucia Piredda; Gian Maria Fimia; Walter Malorni; Mauro Piacentini
Tissue transglutaminase is a multifunctional BH3-only protein.
The Journal of biological chemistry 2004;279(52):54783-92.
2004: Gian Maria Fimia; Cristina Evangelisti; Tonino Alonzi; Marta Romani; Federica Fratini; Giacomo Paonessa; giuseppe ippolito; Marco Tripodi; Mauro Piacentini
Conventional protein kinase C inhibition prevents alpha interferon-mediated hepatitis C virus replicon clearance by impairing STAT activation.
Journal of virology 2004;78(23):12809-16.
2004: veronica bordoni; Tonino Alonzi; Chiara Agrati; Fabrizio Poccia; Giovanna Borsellino; Giorgio Mancino; Gian Maria Fimia; Mauro Piacentini; Antonio Fantoni; Marco Tripodi
Murine hepatocyte cell lines promote expansion and differentiation of NK cells from stem cell precursors.
Hepatology (Baltimore, Md.) 2004;39(6):1508-16.
2004: Delia Goletti; Stefania Carrara; Donatella Vincenti; Elena Giacomini; Lanfranco Fattorini; Anna Rosa Garbuglia; Maria Rosaria Capobianchi; Tonino Alonzi; Gian Maria Fimia; Maurizio Federico; Guido Poli; Eliana M Coccia
Inhibition of HIV-1 replication in monocyte-derived macrophages by Mycobacterium tuberculosis.
The Journal of infectious diseases 2004;189(4):624-33.
2004: Ryuzo Yanagimachi; Teruhiko Wakayama; Hidefumi Kishikawa; Gian Maria Fimia; Lucia Monaco; Paolo Sassone-Corsi
Production of fertile offspring from genetically infertile male mice.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(6):1691-5.
2003: Dario De Cesare; Gian Maria Fimia; Stefano Brancorsini; Martti Parvinen; Paolo Sassone-Corsi
Transcriptional control in male germ cells: general factor TFIIA participates in CREM-dependent gene activation.
Molecular endocrinology (Baltimore, Md.) 2003;17(12):2554-65.
2003: Roberta Nardacci; Oreste Lo Iacono; Fabiola Ciccosanti; Laura Falasca; Maria Addesso; Alessandra Amendola; Giorgio Antonucci; Antonio Craxì; Gian Maria Fimia; Valentina Iadevaia; Gerry Melino; Luigi Ruco; Guido Tocci; Giuseppe Ippolito; Mauro Piacentini
Transglutaminase type II plays a protective role in hepatic injury.
The American journal of pathology 2003;162(4):1293-303.
2003: Gian Maria Fimia; Marco Tripodi; Tonino Alonzi
Transgenic models for Hepatitis C virus pathogenesis.
Cell death and differentiation 2003;10 Suppl 1():S16-8.
2002: Betina Macho; Stefano Brancorsini; Gian Maria Fimia; Mitsutoshi Setou; Nobutaka Hirokawa; Paolo Sassone-Corsi
CREM-dependent transcription in male germ cells controlled by a kinesin.
Science (New York, N.Y.) 2002;298(5602):2388-90.
2002: Claudia Crosio; Gian Maria Fimia; Romain Loury; Masashi Kimura; Yukio Okano; Hongyi Zhou; Subrata Sen; C David Allis; Paolo Sassone-Corsi
Mitotic phosphorylation of histone H3: spatio-temporal regulation by mammalian Aurora kinases.
Molecular and cellular biology 2002;22(3):874-85.
2001: Gian Maria Fimia; A Morlon; Betina Macho; Dario De Cesare; Paolo Sassone-Corsi
Transcriptional cascades during spermatogenesis: pivotal role of CREM and ACT.
Molecular and cellular endocrinology 2001;179(1-2):17-23.
2001: Gian Maria Fimia; Paolo Sassone-Corsi
Cyclic AMP signalling.
Journal of cell science 2001;114(Pt 11):1971-2.
2001: Igor Martianov; Gian Maria Fimia; Andrée Dierich; Martti Parvinen; Paolo Sassone-Corsi; Irwin Davidson
Late arrest of spermiogenesis and germ cell apoptosis in mice lacking the TBP-like TLF/TRF2 gene.
Molecular cell 2001;7(3):509-15.
2000: Gian Maria Fimia; Dario De Cesare; Paolo Sassone-Corsi
A family of LIM-only transcriptional coactivators: tissue-specific expression and selective activation of CREB and CREM.
Molecular and cellular biology 2000;20(22):8613-22.
2000: Dario De Cesare; Gian Maria Fimia; Paolo Sassone-Corsi
CREM, a master-switch of the transcriptional cascade in male germ cells.
Journal of endocrinological investigation 2000;23(9):592-6.
1999: Dario De Cesare; Gian Maria Fimia; Paolo Sassone-Corsi
Signaling routes to CREM and CREB: plasticity in transcriptional activation.
Trends in biochemical sciences 1999;24(7):281-5.
1999: Gian Maria Fimia; Dario De Cesare; Paolo Sassone-Corsi
CBP-independent activation of CREM and CREB by the LIM-only protein ACT.
Nature 1999;398(6723):165-9.
1998: Andrée Dierich; M R Sairam; Lucia Monaco; Gian Maria Fimia; Anne Gansmuller; Marianne LeMeur; Paolo Sassone-Corsi
Impairing follicle-stimulating hormone (FSH) signaling in vivo: targeted disruption of the FSH receptor leads to aberrant gametogenesis and hormonal imbalance.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(23):13612-7.
1998: Gian Maria Fimia; Dario De Cesare; Paolo Sassone-Corsi
Mechanisms of activation by CREB and CREM: phosphorylation, CBP, and a novel coactivator, ACT.
Cold Spring Harbor symposia on quantitative biology 1998;63():631-42.