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Robert Fine

Research Profile

Chemicals & Drugs

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TOP 3
Robert L Fine; Anthony P Gulati; Benjamin A Krantz; James A Lee; Yuehua Mao; Rebecca A Moss; Kelley B Mowatt; Stephen Schreibman; Beth Schrope; William H Sherman; Peter D Stevens; Dawn A Tsushima; John Allendorf; Richard D Dinnen; John A Chabot
Capecitabine and temozolomide (CAPTEM) for metastatic, well-differentiated neuroendocrine cancers: The Pancreas Center at Columbia University experience.
Richard D Dinnen; Yuehua Mao; Robert L Fine
The use of fluorescent probes in the study of reactive oxygen species in pancreatic cancer cells.
Anthony P Gulati; Benjamin Krantz; Rebecca A Moss; Kelley B Mowatt; Wendy N Moyal; Stephen Schreibman; Dawn A Tsushima; Robert L Fine
Treatment of multiple endocrine neoplasia 1/2 tumors: case report and review of the literature.

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All Publications

2013: Robert L Fine; Anthony P Gulati; Benjamin A Krantz; James A Lee; Yuehua Mao; Rebecca A Moss; Kelley B Mowatt; Stephen Schreibman; Beth Schrope; William H Sherman; Peter D Stevens; Dawn A Tsushima; John Allendorf; Richard D Dinnen; John A Chabot
Capecitabine and temozolomide (CAPTEM) for metastatic, well-differentiated neuroendocrine cancers: The Pancreas Center at Columbia University experience.
Cancer chemotherapy and pharmacology 2013;71(3):663-70.
2013: Richard D Dinnen; Yuehua Mao; Robert L Fine
The use of fluorescent probes in the study of reactive oxygen species in pancreatic cancer cells.
Methods in molecular biology (Clifton, N.J.) 2013;980():321-9.
2013: Anthony P Gulati; Benjamin Krantz; Rebecca A Moss; Kelley B Mowatt; Wendy N Moyal; Stephen Schreibman; Dawn A Tsushima; Robert L Fine
Treatment of multiple endocrine neoplasia 1/2 tumors: case report and review of the literature.
Oncology 2013;84(3):127-34.
2011: Jeffrey N Bruce; Peter Canoll; Emilia Bagiella; Robert L Fine; Benjamin C Kennedy; Rose Lai; Steven S Rosenfeld; Stephen A Sands; Krishna Surapaneni; Candix L Yanes; Jonathan Yun; Robert DeLaPaz
Regression of recurrent malignant gliomas with convection-enhanced delivery of topotecan.
Neurosurgery 2011;69(6):1272-9; discussion 1279-80.
2011: Marie S Thearle; Jeffrey N Bruce; Pamela U Freda; Steven R Isaacson; Yoomi Lee; Robert L Fine
Temozolomide (Temodar®) and capecitabine (Xeloda®) treatment of an aggressive corticotroph pituitary tumor.
Pituitary 2011;14(4):418-24.
2011: Shailendra Joshi; Roberto Reif; Mei Wang; Jane Zhang; Jeffery N Bruce; Aysegul Ergin; Robert L Fine; Irving J Bigio
Intra-arterial mitoxantrone delivery in rabbits: an optical pharmacokinetic study.
Neurosurgery 2011;69(3):706-12; discussion 712.
2010: Elizabeth C Verna; Caroline Hwang; Peter D Stevens; Heidrun Rotterdam; Stavros N Stavropoulos; Carolyn D Sy; Martin A Prince; Wendy Chung; Robert L Fine; John A Chabot; Harold Frucht
Pancreatic cancer screening in a prospective cohort of high-risk patients: a comprehensive strategy of imaging and genetics.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(20):5028-37.
2010: John A Chabot; Wei-Yann Tsai; Robert L Fine; Chunxia Chen; Carolyn K Kumah; Karen A Antman; Victor R Grann
Pancreatic proteolytic enzyme therapy compared with gemcitabine-based chemotherapy for the treatment of pancreatic cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2010;28(12):2058-63.
2008: Frank Schönleben; John Allendorf; Wanglong Qiu; Xiaojun Li; Daniel J Ho; Nancy T Ciau; Robert L Fine; John A Chabot; Helen E Remotti; Gloria H Su
Mutational analyses of multiple oncogenic pathways in intraductal papillary mucinous neoplasms of the pancreas.
Pancreas 2008;36(2):168-72.
2008: John Allendorf; Margaret Lauerman; Aliye Bill; Mary DiGiorgi; Nicole Goetz; Efsevia Vakiani; Helen E Remotti; Beth A Schrope; william sherman; Michael Hall; Robert L Fine; John A Chabot
Neoadjuvant chemotherapy and radiation for patients with locally unresectable pancreatic adenocarcinoma: feasibility, efficacy, and survival.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2008;12(1):91-100.
2008: Shailendra Joshi; Mei Wang; Joshua` Etu; Raymond F Suckow; Thomas B Cooper; Steven J Feinmark; Jeffrey N Bruce; Robert L Fine
Transient cerebral hypoperfusion enhances intraarterial carmustine deposition into brain tissue.
Journal of neuro-oncology 2008;86(2):123-32.
2008: Robert L Fine; David R Fogelman; Stephen M Schreibman; Manisha Desai; william sherman; James Strauss; Susan Guba; Riolan Andrade; John Chabot
The gemcitabine, docetaxel, and capecitabine (GTX) regimen for metastatic pancreatic cancer: a retrospective analysis.
Cancer chemotherapy and pharmacology 2008;61(1):167-75.
2007: Richard D Dinnen; Lisa Drew; Daniel P Petrylak; Yuehua Mao; Nicholas D Cassai; Joseph Szmulewicz; Paul W Brandt-Rauf; Robert L Fine
Activation of targeted necrosis by a p53 peptide: a novel death pathway that circumvents apoptotic resistance.
The Journal of biological chemistry 2007;282(37):26675-86.
2007: Robert L Fine; Samir S Shah; Thomas Moulton; Ing-Ru Yu; David R Fogelman; Michael Richardson; Howard A Burris; Brian L Samuels; Chatchawin Assanasen; Prakash Gorroochurn; Hanina Hibshoosh; Manuela A Orjuela; James Garvin; Frederick D Goldman; Daniel Dubovsky; David Walterhouse; Gregory Halligan
Androgen and c-Kit receptors in desmoplastic small round cell tumors resistant to chemotherapy: novel targets for therapy.
Cancer chemotherapy and pharmacology 2007;59(4):429-37.
2007: Irina Lebedeva; Ilyas Washington; Devanand Sarkar; Jennifer A Clark; Robert L Fine; Paul Dent; David T Curiel; Nicholas J Turro; Paul B Fisher
Strategy for reversing resistance to a single anticancer agent in human prostate and pancreatic carcinomas.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(9):3484-9.
2006: Robert L Fine; Johnson Chen; Casilda Balmaceda; Jeffrey N Bruce; May Huang; Manisha Desai; Michael B Sisti; Guy M McKhann; Robert R Goodman; Joseph S Bertino; Anne N Nafziger; Michael R Fetell
Randomized study of paclitaxel and tamoxifen deposition into human brain tumors: implications for the treatment of metastatic brain tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(19):5770-6.
2006: Josef Michl; Bruce Scharf; Anna Schmidt; Chan Huynh; Raquibul Hannan; Hans Von Gizycki; Fred Friedman; Paul W Brandt-Rauf; Robert L Fine; Matthew R Pincus
PNC-28, a p53-derived peptide that is cytotoxic to cancer cells, blocks pancreatic cancer cell growth in vivo.
International journal of cancer. Journal international du cancer 2006;119(7):1577-85.
2006: Joseph J Carter; Daniel L Feingold; Anthony Oh; Irena Kirman; Peer Wildbrett; George Stapleton; Zishan Asi; Ryan Fowler; Govind Bhagat; Emina H Huang; Robert L Fine; Richard L Whelan
Perioperative immunomodulation with Flt3 kinase ligand or a whole tumor cell vaccine is associated with a reduction in lung metastasis formation after laparotomy in mice.
Surgical innovation 2006;13(1):41-7.
2006: Patrick B Senatus; Yin Li; Christopher E Mandigo; Gwen Nichols; Gaetan Moise; Yuehua Mao; Melandee D Brown; Richard C E Anderson; Andrew T Parsa; Paul W Brandt-Rauf; Jeffrey N Bruce; Robert L Fine
Restoration of p53 function for selective Fas-mediated apoptosis in human and rat glioma cells in vitro and in vivo by a p53 COOH-terminal peptide.
Molecular cancer therapeutics 2006;5(1):20-8.
2006: Johnson Chen; Casilda Balmaceda; Jeffrey N Bruce; Michael B Sisti; May Huang; Ying Kuen K Cheung; Guy M McKhann; Robert R Goodman; Robert L Fine
Tamoxifen paradoxically decreases paclitaxel deposition into cerebrospinal fluid of brain tumor patients.
Journal of neuro-oncology 2006;76(1):85-92.
2005: Joseph J Carter; Daniel L Feingold; Peer Wildbrett; Anthony Oh; Irena Kirman; Zishan Asi; George Stapleton; Emina Huang; Robert L Fine; Richard L Whelan
Significant reduction of laparotomy-associated lung metastases and subcutaneous tumors after perioperative immunomodulation with flt3 ligand in mice.
Surgical innovation 2005;12(4):319-25.
2005: Yin Li; Yuehua Mao; Paul W Brandt-Rauf; Ann C Williams; Robert L Fine
Selective induction of apoptosis in mutant p53 premalignant and malignant cancer cells by PRIMA-1 through the c-Jun-NH2-kinase pathway.
Molecular cancer therapeutics 2005;4(6):901-9.
2005: Yin Li; Yuehua Mao; Ramon V Rosal; Richard D Dinnen; Ann C Williams; Paul W Brandt-Rauf; Robert L Fine
Selective induction of apoptosis through the FADD/caspase-8 pathway by a p53 c-terminal peptide in human pre-malignant and malignant cells.
International journal of cancer. Journal international du cancer 2005;115(1):55-64.
2005: Ramon V Rosal; Paul W Brandt-Rauf; Matthew R Pincus; Hsin Wang; Yuehua Mao; Yin Li; Robert L Fine
The role of alpha-helical structure in p53 peptides as a determinant for their mechanism of cell death: necrosis versus apoptosis.
Advanced drug delivery reviews 2005;57(4):653-60.
2005: Howard Kaufman; Amir Harandi; Matthew C Watson; Eric L Carter; Gail DeRaffele; Mohammad Shahid; Robert L Fine
Panniculitis after vaccination against CEA and MUC1 in a patient with pancreatic cancer.
The lancet oncology 2005;6(1):62-3.
2004: David R Fogelman; Johnson Chen; John A Chabot; John Allendorf; Beth A Schrope; Ronald Ennis; Stephen M Schreibman; Robert L Fine
The evolution of adjuvant and neoadjuvant chemotherapy and radiation for advanced pancreatic cancer: from 5-fluorouracil to GTX.
Surgical oncology clinics of North America 2004;13(4):711-35, x.
2004: Paul W Brandt-Rauf; Ramon V Rosal; Robert L Fine; Matthew R Pincus
Computational protein chemistry of p53 and p53 peptides.
Frontiers in bioscience : a journal and virtual library 2004;9():2778-87.
2004: Ramon V Rosal; Matthew R Pincus; Paul W Brandt-Rauf; Robert L Fine; Josef Michl; Hsin Wang
NMR solution structure of a peptide from the mdm-2 binding domain of the p53 protein that is selectively cytotoxic to cancer cells.
Biochemistry 2004;43(7):1854-61.
2003: Yin Li; Anthony J Raffo; Lisa Drew; Yuehua Mao; Andy Tran; Daniel P Petrylak; Robert L Fine
Fas-mediated apoptosis is dependent on wild-type p53 status in human cancer cells expressing a temperature-sensitive p53 mutant alanine-143.
Cancer research 2003;63(7):1527-33.
2003: Tamara N Do; Ramon V Rosal; Lisa Drew; Anthony J Raffo; Josef Michl; Matthew R Pincus; Fred Friedman; Daniel P Petrylak; Nicholas D Cassai; Joseph Szmulewicz; Gurdip S Sidhu; Robert L Fine; Paul W Brandt-Rauf
Preferential induction of necrosis in human breast cancer cells by a p53 peptide derived from the MDM2 binding site.
Oncogene 2003;22(10):1431-44.
2002: Lisa Drew; Robert L Fine; Tamara N Do; Geoffrey P Douglas; Daniel P Petrylak
The novel antimicrotubule agent cryptophycin 52 (LY355703) induces apoptosis via multiple pathways in human prostate cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(12):3922-32.
2002: Yin Li; Ramon V Rosal; Paul W Brandt-Rauf; Robert L Fine
Correlation between hydrophobic properties and efficiency of carrier-mediated membrane transduction and apoptosis of a p53 C-terminal peptide.
Biochemical and biophysical research communications 2002;298(3):439-49.
2001: Mecheal Kanovsky; Anthony J Raffo; Lisa Drew; Ramon V Rosal; Tamara N Do; Fred Friedman; P Rubinstein; J Visser; Richard Robinson; Paul W Brandt-Rauf; Josef Michl; Robert L Fine; Matthew R Pincus
Peptides from the amino terminal mdm-2-binding domain of p53, designed from conformational analysis, are selectively cytotoxic to transformed cells.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(22):12438-43.
2000: Anthony J Raffo; Arianna L Kim; Robert L Fine
Formation of nuclear Bax/p53 complexes is associated with chemotherapy induced apoptosis.
Oncogene 2000;19(54):6216-28.
2000: Michael G Kaiser; Andrew T Parsa; Robert L Fine; JS Hall; I Chakrabarti; Jeffrey N Bruce
Tissue distribution and antitumor activity of topotecan delivered by intracerebral clysis in a rat glioma model.
Neurosurgery 2000;47(6):1391-8; discussion 1398-9.
2000: Jeffrey N Bruce; A Falavigna; J P Johnson; JS Hall; B D Birch; Jung-Taek Yoon; E X Wu; Robert L Fine; Andrew T Parsa
Intracerebral clysis in a rat glioma model.
Neurosurgery 2000;46(3):683-91.
1999: Arianna L Kim; Anthony J Raffo; Paul W Brandt-Rauf; Matthew R Pincus; Regina Monaco; P Abarzua; Robert L Fine
Conformational and molecular basis for induction of apoptosis by a p53 C-terminal peptide in human cancer cells.
The Journal of biological chemistry 1999;274(49):34924-31.