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Moshe Finel

Research Profile

Chemicals & Drugs

Concepts & Ideas

Genes & Molecular Sequences

Amino Acid Sequences

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Anatomy

Microsomes, Liver

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TOP 3
Nina Sneitz; Mikko Vahermo; Liisa Laakkonen; Johanna Mosorin; Donald Poirier; Moshe Finel
Regiospecificity and stereospecificity of human UDP-glucuronosyltransferases in the glucuronidation of estriol, 16-epiestriol, 17-epiestriol, and 13-epiestradiol.
Nenad Manevski; Paolo Svaluto-Moreolo; Johanna Troberg; Jari Yli-Kauhaluoma; Klaudyna Dziedzic; Moshe Finel
Albumin stimulates the activity of the human UDP-glucuronosyltransferases 1A7, 1A8, 1A10, 2A1 and 2B15, but the effects are enzyme and substrate dependent.
Hongbo Zhang; Jouni Hirvonen; Timo Rousu; AI Soikkeli; Ari Tolonen; Moshe Finel
Highly variable pH effects on the interaction of diclofenac and indomethacin with human UDP-glucuronosyltransferases.

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All Publications

2013: Nina Sneitz; Mikko Vahermo; Liisa Laakkonen; Johanna Mosorin; Donald Poirier; Moshe Finel
Regiospecificity and stereospecificity of human UDP-glucuronosyltransferases in the glucuronidation of estriol, 16-epiestriol, 17-epiestriol, and 13-epiestradiol.
Drug metabolism and disposition: the biological fate of chemicals 2013;41(3):582-91.
2013: Nenad Manevski; Paolo Svaluto-Moreolo; Johanna Troberg; Jari Yli-Kauhaluoma; Klaudyna Dziedzic; Moshe Finel
Albumin stimulates the activity of the human UDP-glucuronosyltransferases 1A7, 1A8, 1A10, 2A1 and 2B15, but the effects are enzyme and substrate dependent.
PloS one 2013;8(1):e54767.
2012: Hongbo Zhang; Jouni Hirvonen; Timo Rousu; AI Soikkeli; Ari Tolonen; Moshe Finel
Highly variable pH effects on the interaction of diclofenac and indomethacin with human UDP-glucuronosyltransferases.
Toxicology in vitro : an international journal published in association with BIBRA 2012;26(8):1286-93.
2012: Nenad Manevski; Jari Yli-Kauhaluoma; Moshe Finel
UDP-glucuronic acid binds first and the aglycone substrate binds second to form a ternary complex in UGT1A9-catalyzed reactions, in both the presence and absence of bovine serum albumin.
Drug metabolism and disposition: the biological fate of chemicals 2012;40(11):2192-203.
2012: Hongbo Zhang; Adrian Goldman; Shin-ichi Ikushiro; Peter I Mackenzie; Anne-Sisko Patana; Moshe Finel
Human UDP-glucuronosyltransferase expression in insect cells: ratio of active to inactive recombinant proteins and the effects of a C-terminal his-tag on glucuronidation kinetics.
Drug metabolism and disposition: the biological fate of chemicals 2012;40(10):1935-44.
2012: Barbara Fedejko-Kap; Moshe Finel; Stacie Bratton; Anna Radominska-Pandya; Zofia Mazerska
Role of human UDP-glucuronosyltransferases in the biotransformation of the triazoloacridinone and imidazoacridinone antitumor agents C-1305 and C-1311: highly selective substrates for UGT1A10.
Drug metabolism and disposition: the biological fate of chemicals 2012;40(9):1736-43.
2012: Paula S Montenegro-Miranda; Nina Sneitz; Lysbeth ten Bloemendaal; Ulrich Beuers; Robert J de Knegt; Dirk R de Waart; Suzanne Duijst; Moshe Finel; Piter J Bosma
Ezetimibe: A biomarker for efficacy of liver directed UGT1A1 gene therapy for inherited hyperbilirubinemia.
Biochimica et biophysica acta 2012;1822(8):1223-9.
2012: Heidi Kidron; Nenad Manevski; Moshe Finel; Marika Häkli; Raimo A Ketola; Gloria Wissel; Henri Xhaard; Marjo Yliperttula; Arto Urtti
Impact of probe compound in MRP2 vesicular transport assays.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2012;46(1-2):100-5.
2012: Liangliang Zhu; Hongbo Zhang; Yanyan Zhang; Peipei Dong; Zhongze Fang; Moshe Finel; Guangbo Ge; Guiyuan He; Sicheng Liang; Huixin Liu; Ling Yang
Characterization of hepatic and intestinal glucuronidation of magnolol: application of the relative activity factor approach to decipher the contributions of multiple UDP-glucuronosyltransferase isoforms.
Drug metabolism and disposition: the biological fate of chemicals 2012;40(3):529-38.
2012: Michael H Court; Xinxin Ding; Leah M Hesse; Karen K Yee; Xiuling Zhang; Moshe Finel
Quantitative distribution of mRNAs encoding the 19 human UDP-glucuronosyltransferase enzymes in 26 adult and 3 fetal tissues.
Xenobiotica; the fate of foreign compounds in biological systems 2012;42(3):266-77.
2011: Camilla Höglund; Liisa Laakonen; Anna Radominska-Pandya; Nina Sneitz; Moshe Finel
Phenylalanine 93 of the human UGT1A10 plays a major role in the interactions of the enzyme with estrogens.
Steroids 2011;76(13):1465-73.
2011: Nina Sneitz; Kathiresan Krishnan; Douglas F Covey; Moshe Finel
Glucuronidation of the steroid enantiomers ent-17β-estradiol, ent-androsterone and ent-etiocholanolone by the human UDP-glucuronosyltransferases.
The Journal of steroid biochemistry and molecular biology 2011;127(3-5):282-8.
2011: Nenad Manevski; Paolo Svaluto Moreolo; Jari Yli-Kauhaluoma; Moshe Finel
Bovine serum albumin decreases Km values of human UDP-glucuronosyltransferases 1A9 and 2B7 and increases Vmax values of UGT1A9.
Drug metabolism and disposition: the biological fate of chemicals 2011;39(11):2117-29.
2011: AI Soikkeli; Marjo Yliperttula; Jouni Hirvonen; Mika Kurkela; Moshe Finel
Fluorescence-based high-throughput screening assay for drug interactions with UGT1A6.
Assay and drug development technologies 2011;9(5):496-502.
2011: Sanna Kaivosaari; Moshe Finel; Mikko Koskinen
N-glucuronidation of drugs and other xenobiotics by human and animal UDP-glucuronosyltransferases.
Xenobiotica; the fate of foreign compounds in biological systems 2011;41(8):652-69.
2011: Hongbo Zhang; Ari Tolonen; Timo Rousu; Jouni Hirvonen; Moshe Finel
Effects of cell differentiation and assay conditions on the UDP-glucuronosyltransferase activity in Caco-2 cells.
Drug metabolism and disposition: the biological fate of chemicals 2011;39(3):456-64.
2010: Päivi Lehtonen; Taina Sten; Olli Aitio; Mika Kurkela; Katariina Vuorensola; Moshe Finel; Risto Kostiainen
Glucuronidation of racemic O-desmethyltramadol, the active metabolite of tramadol.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2010;41(3-4):523-30.
2010: Liisa Laakkonen; Moshe Finel
A molecular model of the human UDP-glucuronosyltransferase 1A1, its membrane orientation, and the interactions between different parts of the enzyme.
Molecular pharmacology 2010;77(6):931-9.
2010: Katriina Itäaho; Liisa Laakkonen; Moshe Finel
How many and which amino acids are responsible for the large activity differences between the highly homologous UDP-glucuronosyltransferases (UGT) 1A9 and UGT1A10?
Drug metabolism and disposition: the biological fate of chemicals 2010;38(4):687-96.
2010: Nenad Manevski; Mika Kurkela; Camilla Höglund; Timo Mauriala; Michael H Court; Jari Yli-Kauhaluoma; Moshe Finel
Glucuronidation of psilocin and 4-hydroxyindole by the human UDP-glucuronosyltransferases.
Drug metabolism and disposition: the biological fate of chemicals 2010;38(3):386-95.
2010: Sanna Siissalo; Laura Laine; Ari Tolonen; Ann Marie Kaukonen; Moshe Finel; Jouni Hirvonen
Caco-2 cell monolayers as a tool to study simultaneous phase II metabolism and metabolite efflux of indomethacin, paracetamol and 1-naphthol.
International journal of pharmaceutics 2010;383(1-2):24-9.
2010: Nina Sneitz; Conny T Bakker; Robert J de Knegt; Dicky J J Halley; Moshe Finel; Piter J Bosma
Crigler-Najjar syndrome in The Netherlands: identification of four novel UGT1A1 alleles, genotype-phenotype correlation, and functional analysis of 10 missense mutants.
Human mutation 2010;31(1):52-9.
2009: Nina Sneitz; Karen K Yee; Xiuling Zhang; Kaisa Laajanen; Michael H Court; Pamela Dalton; Xinxin Ding; Moshe Finel
Human UDP-glucuronosyltransferase UGT2A2: cDNA construction, expression, and functional characterization in comparison with UGT2A1 and UGT2A3.
Pharmacogenetics and genomics 2009;19(12):923-34.
2009: Taina Sten; Mika Kurkela; Tiia Kuuranne; Antti Leinonen; Moshe Finel
UDP-glucuronosyltransferases in conjugation of 5alpha- and 5beta-androstane steroids.
Drug metabolism and disposition: the biological fate of chemicals 2009;37(11):2221-7.
2009: Taina Sten; Moshe Finel; Birgitta Ask; Anders Rane; Lena Ekström
Non-steroidal anti-inflammatory drugs interact with testosterone glucuronidation.
Steroids 2009;74(12):971-7.
2009: Oranun Kerdpin; Peter I Mackenzie; Kushari Bowalgaha; Moshe Finel; John O Miners
Influence of N-terminal domain histidine and proline residues on the substrate selectivities of human UDP-glucuronosyltransferase 1A1, 1A6, 1A9, 2B7, and 2B10.
Drug metabolism and disposition: the biological fate of chemicals 2009;37(9):1948-55.
2009: Anna Alonen; Minna Gartman; Olli Aitio; Moshe Finel; Jari Yli-Kauhaluoma; Risto Kostiainen
Synthesis, structure characterization, and enzyme screening of clenbuterol glucuronides.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2009;37(5):581-7.
2009: Gustav Boije af Gennäs; Virpi Talman; Olli Aitio; Elina Ekokoski; Moshe Finel; Raimo K Tuominen; Jari Yli-Kauhaluoma
Design, synthesis, and biological activity of isophthalic acid derivatives targeted to the C1 domain of protein kinase C.
Journal of medicinal chemistry 2009;52(13):3969-81.
2009: Anna Mazur; Cheryl F Lichti; Paul L Prather; Agnieszka K Zielinska; Stacie Bratton; Anna Gallus-Zawada; Moshe Finel; Grover P Miller; Anna Radomińska-Pandya; Jeffery H Moran
Characterization of human hepatic and extrahepatic UDP-glucuronosyltransferase enzymes involved in the metabolism of classic cannabinoids.
Drug metabolism and disposition: the biological fate of chemicals 2009;37(7):1496-504.
2009: Katriina Itäaho; Michael H Court; Päivi Uutela; Risto Kostiainen; Anna Radominska-Pandya; Moshe Finel
Dopamine is a low-affinity and high-specificity substrate for the human UDP-glucuronosyltransferase 1A10.
Drug metabolism and disposition: the biological fate of chemicals 2009;37(4):768-75.
2009: Taina Sten; Ingo Bichlmaier; Tiia Kuuranne; Antti Leinonen; Jari Yli-Kauhaluoma; Moshe Finel
UDP-glucuronosyltransferases (UGTs) 2B7 and UGT2B17 display converse specificity in testosterone and epitestosterone glucuronidation, whereas UGT2A1 conjugates both androgens similarly.
Drug metabolism and disposition: the biological fate of chemicals 2009;37(2):417-23.
2008: Grover P Miller; Cheryl F Lichti; Agnieszka K Zielinska; Anna Mazur; Stacie Bratton; Anna Gallus-Zawada; Moshe Finel; Jeffery H Moran; Anna Radominska-Pandya
Identification of hydroxywarfarin binding site in human UDP glucuronosyltransferase 1a10: phenylalanine90 is crucial for the glucuronidation of 6- and 7-hydroxywarfarin but not 8-hydroxywarfarin.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(11):2211-8.
2008: Katriina Itäaho; Peter I Mackenzie; Shin-ichi Ikushiro; John O Miners; Moshe Finel
The configuration of the 17-hydroxy group variably influences the glucuronidation of beta-estradiol and epiestradiol by human UDP-glucuronosyltransferases.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(11):2307-15.
2008: Sanna Siissalo; Hongbo Zhang; Eric Stilgenbauer; Ann Marie Kaukonen; Jouni Hirvonen; Moshe Finel
The expression of most UDP-glucuronosyltransferases (UGTs) is increased significantly during Caco-2 cell differentiation, whereas UGT1A6 is highly expressed also in undifferentiated cells.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(11):2331-6.
2008: Anna Alonen; Moshe Finel; Risto Kostiainen
The human UDP-glucuronosyltransferase UGT1A3 is highly selective towards N2 in the tetrazole ring of losartan, candesartan, and zolarsartan.
Biochemical pharmacology 2008;76(6):763-72.
2008: Michael H Court; Suwagmani Hazarika; Soundararajan Krishnaswamy; Moshe Finel; J Andrew Williams
Novel polymorphic human UDP-glucuronosyltransferase 2A3: cloning, functional characterization of enzyme variants, comparative tissue expression, and gene induction.
Molecular pharmacology 2008;74(3):744-54.
2008: Anne-Sisko Patana; Mika Kurkela; Moshe Finel; Adrian Goldman
Mutation analysis in UGT1A9 suggests a relationship between substrate and catalytic residues in UDP-glucuronosyltransferases.
Protein engineering, design & selection : PEDS 2008;21(9):537-43.
2008: Olga Trubetskoy; Moshe Finel; Vladimir Trubetskoy
High-throughput screening technologies for drug glucuronidation profiling.
The Journal of pharmacy and pharmacology 2008;60(8):1061-7.
2008: Sanna Kaivosaari; Päivi Toivonen; Olli Aitio; Julius Sipilä; Mikko Koskinen; Jarmo S Salonen; Moshe Finel
Regio- and stereospecific N-glucuronidation of medetomidine: the differences between UDP glucuronosyltransferase (UGT) 1A4 and UGT2B10 account for the complex kinetics of human liver microsomes.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(8):1529-37.
2008: Anna Alonen; Johanna Jansson; Sirkku Kallonen; Alexandros Kiriazis; Olli Aitio; Moshe Finel; Risto Kostiainen
Enzyme-assisted synthesis and structure characterization of glucuronic acid conjugates of losartan, candesartan, and zolarsartan.
Bioorganic chemistry 2008;36(3):148-55.
2008: Yan Xiong; Anne-Sisko Patana; Michael Miley; Agnieszka K Zielinska; Stacie Bratton; Grover P Miller; Adrian Goldman; Moshe Finel; Matt R Redinbo; Anna Radominska-Pandya
The first aspartic acid of the DQxD motif for human UDP-glucuronosyltransferase 1A10 interacts with UDP-glucuronic acid during catalysis.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(3):517-22.
2008: Laura Riihimäki; Anna Galkin; Moshe Finel; Jonna Heikura; Kaija H Valkonen; Vesa Virtanen; Reijo Laaksonen; J Peter Slotte; Pia Vuorela
Transport properties of bovine and reindeer beta-lactoglobulin in the Caco-2 cell model.
International journal of pharmaceutics 2008;347(1-2):1-8.
2008: Moshe Finel; Mika Kurkela
The UDP-glucuronosyltransferases as oligomeric enzymes.
Current drug metabolism 2008;9(1):70-6.
2008: Agnieszka Zielinska; Cheryl F Lichti; Stacie Bratton; Neil C Mitchell; Anna Gallus-Zawada; Vi-Huyen Le; Moshe Finel; Grover P Miller; Anna Radominska-Pandya; Jeffery H Moran
Glucuronidation of monohydroxylated warfarin metabolites by human liver microsomes and human recombinant UDP-glucuronosyltransferases.
The Journal of pharmacology and experimental therapeutics 2008;324(1):139-48.
2008: Jukka Pätsi; Marko Kervinen; Moshe Finel; Ilmo E Hassinen
Leber hereditary optic neuropathy mutations in the ND6 subunit of mitochondrial complex I affect ubiquinone reduction kinetics in a bacterial model of the enzyme.
The Biochemical journal 2008;409(1):129-37.
2007: Ingo Bichlmaier; Moshe Finel; Wolfgang Sippl; Jari Yli-Kauhaluoma
Stereochemical and steric control of the UDP-glucuronosyltransferase-catalyzed conjugation reaction: a rational approach for the design of inhibitors for the human UGT2B7.
ChemMedChem 2007;2(12):1730-40.
2007: Ingo Bichlmaier; Mika Kurkela; Antti Siiskonen; Moshe Finel; Jari Yli-Kauhaluoma
Eudismic analysis of tricyclic sesquiterpenoid alcohols: lead structures for the design of potent inhibitors of the human UDP-glucuronosyltransferase 2B7.
Bioorganic chemistry 2007;35(5):386-400.
2007: Anne-Sisko Patana; Mika Kurkela; Adrian Goldman; Moshe Finel
The human UDP-glucuronosyltransferase: identification of key residues within the nucleotide-sugar binding site.
Molecular pharmacology 2007;72(3):604-11.
2007: Sanna Kaivosaari; Päivi Toivonen; Leah M Hesse; Mikko Koskinen; Michael H Court; Moshe Finel
Nicotine glucuronidation and the human UDP-glucuronosyltransferase UGT2B10.
Molecular pharmacology 2007;72(3):761-8.
2007: O V Trubetskoy; Moshe Finel; Mika Kurkela; M Fitzgerald; noel peters; F M Hoffman; Vladimir S Trubetskoy
High throughput screening assay for UDP-glucuronosyltransferase 1A1 glucuronidation profiling.
Assay and drug development technologies 2007;5(3):343-54.
2007: Ingo Bichlmaier; Mika Kurkela; Tanmaya Joshi; Antti Siiskonen; Tobias Rüffer; Heinrich Lang; Moshe Finel; Jari Yli-Kauhaluoma
Potent inhibitors of the human UDP-glucuronosyltransferase 2B7 derived from the sesquiterpenoid alcohol longifolol.
ChemMedChem 2007;2(6):881-9.
2007: Ingo Bichlmaier; Mika Kurkela; Tanmaya Joshi; Antti Siiskonen; Tobias Rüffer; Heinrich Lang; Bohumila Suchanova; Mikko Vahermo; Moshe Finel; Jari Yli-Kauhaluoma
Isoform-selective inhibition of the human UDP-glucuronosyltransferase 2B7 by isolongifolol derivatives.
Journal of medicinal chemistry 2007;50(11):2655-64.
2007: Lydia Barre; Sylvie Fournel-Gigleux; Moshe Finel; Patrick Netter; Jacques Magdalou; Mohamed Ouzzine
Substrate specificity of the human UDP-glucuronosyltransferase UGT2B4 and UGT2B7. Identification of a critical aromatic amino acid residue at position 33.
The FEBS journal 2007;274(5):1256-64.
2007: Mika Kurkela; Anne-Sisko Patana; Peter I Mackenzie; Michael H Court; Christopher G Tate; Jouni Hirvonen; Adrian Goldman; Moshe Finel
Interactions with other human UDP-glucuronosyltransferases attenuate the consequences of the Y485D mutation on the activity and substrate affinity of UGT1A6.
Pharmacogenetics and genomics 2007;17(2):115-26.
2007: Athena Starlard-Davenport; Yan Xiong; Stacie Bratton; Anna Gallus-Zawada; Moshe Finel; Anna Radominska-Pandya
Phenylalanine(90) and phenylalanine(93) are crucial amino acids within the estrogen binding site of the human UDP-glucuronosyltransferase 1A10.
Steroids 2007;72(1):85-94.
2006: Marko Kervinen; Reetta Hinttala; Heli M Helander; Sari Kurki; Johanna Uusimaa; Moshe Finel; Kari Majamaa; Ilmo E Hassinen
The MELAS mutations 3946 and 3949 perturb the critical structure in a conserved loop of the ND1 subunit of mitochondrial complex I.
Human molecular genetics 2006;15(17):2543-52.
2006: Taina Sten; Saana Qvisen; Päivi Uutela; Leena Luukkanen; Risto Kostiainen; Moshe Finel
Prominent but reverse stereoselectivity in propranolol glucuronidation by human UDP-glucuronosyltransferases 1A9 and 1A10.
Drug metabolism and disposition: the biological fate of chemicals 2006;34(9):1488-94.
2006: Ingo Bichlmaier; Antti Siiskonen; Mika Kurkela; Moshe Finel; Jari Yli-Kauhaluoma
Chiral distinction between the enantiomers of bicyclic alcohols by UDP-glucuronosyltransferases 2B7 and 2B17.
Biological chemistry 2006;387(4):407-16.
2006: Ingo Bichlmaier; Antti Siiskonen; Moshe Finel; Jari Yli-Kauhaluoma
Stereochemical sensitivity of the human UDP-glucuronosyltransferases 2B7 and 2B17.
Journal of medicinal chemistry 2006;49(5):1818-27.
2006: Yan Xiong; Dan Bernardi; Stacie Bratton; Michael D Ward; Eric Battaglia; Moshe Finel; Richard R Drake; Anna Radominska-Pandya
Phenylalanine 90 and 93 are localized within the phenol binding site of human UDP-glucuronosyltransferase 1A10 as determined by photoaffinity labeling, mass spectrometry, and site-directed mutagenesis.
Biochemistry 2006;45(7):2322-32.
2006: Olga V Trubetskoy; Moshe Finel; Thomas J Burke; Vladimir S Trubetskoy
Evaluation of synthetic polymeric micelles as a stabilization medium for the handling of membrane proteins in pharmaceutical drug discovery.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Société canadienne des sciences pharmaceutiques 2006;9(3):271-80.
2005: Moshe Finel; Xin Li; Dione A Gardner-Stephen; Stacie Bratton; Peter I Mackenzie; Anna Radominska-Pandya
Human UDP-glucuronosyltransferase 1A5: identification, expression, and activity.
The Journal of pharmacology and experimental therapeutics 2005;315(3):1143-9.
2005: Charlotta Sandler; Elina Ekokoski; Ken A Lindstedt; Petri J Vainio; Moshe Finel; Timo Sorsa; Petri T Kovanen; Lorne M Golub; Kari K Eklund
Chemically modified tetracycline (CMT)-3 inhibits histamine release and cytokine production in mast cells: possible involvement of protein kinase C.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2005;54(7):304-12.
2005: Leena Luukkanen; Jyrki Taskinen; Mika Kurkela; Risto Kostiainen; Jouni Hirvonen; Moshe Finel
Kinetic characterization of the 1A subfamily of recombinant human UDP-glucuronosyltransferases.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(7):1017-26.
2005: Saurabh Sen; Veli-Pekka Jaakola; Päivi Pirilä; Moshe Finel; Adrian Goldman
Functional studies with membrane-bound and detergent-solubilized alpha2-adrenergic receptors expressed in Sf9 cells.
Biochimica et biophysica acta 2005;1712(1):62-70.
2005: Kati S Hakala; Bohumila Suchanova; Leena Luukkanen; Raimo A Ketola; Moshe Finel; Risto Kostiainen
Rapid simultaneous determination of metabolic clearance of multiple compounds catalyzed in vitro by recombinant human UDP-glucuronosyltransferases.
Analytical biochemistry 2005;341(1):105-12.
2005: Anna Alonen; Olli Aitio; Kati S Hakala; Leena Luukkanen; Moshe Finel; Risto Kostiainen
Biosynthesis of dobutamine monoglucuronides and glucuronidation of dobutamine by recombinant human UDP-glucuronosyltransferases.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(5):657-63.
2004: Mika Kurkela; Jouni Hirvonen; Risto Kostiainen; Moshe Finel
The interactions between the N-terminal and C-terminal domains of the human UDP-glucuronosyltransferases are partly isoform-specific, and may involve both monomers.
Biochemical pharmacology 2004;68(12):2443-50.
2004: Joanna M Little; Mika Kurkela; Julia Sonka; Sirkku Jäntti; Raimo A Ketola; Stacie Bratton; Moshe Finel; Anna Radominska-Pandya
Glucuronidation of oxidized fatty acids and prostaglandins B1 and E2 by human hepatic and recombinant UDP-glucuronosyltransferases.
Journal of lipid research 2004;45(9):1694-703.
2004: Mika Kurkela; Antti Siiskonen; Moshe Finel; Päivi Tammela; Jyrki Taskinen; Pia Vuorela
Microplate screening assay to identify inhibitors of human catechol-O-methyltransferase.
Analytical biochemistry 2004;331(1):198-200.
2004: Mika Kurkela; Saila Mörsky; Jouni Hirvonen; Risto Kostiainen; Moshe Finel
An active and water-soluble truncation mutant of the human UDP-glucuronosyltransferase 1A9.
Molecular pharmacology 2004;65(4):826-31.
2004: Anke Stroh; Oliver Anderka; Kathy Pfeiffer; Takao Yagi; Moshe Finel; Bernd Ludwig; Anke von Renthe-Fink
Assembly of respiratory complexes I, III, and IV into NADH oxidase supercomplex stabilizes complex I in Paracoccus denitrificans.
The Journal of biological chemistry 2004;279(6):5000-7.
2004: Marko Kervinen; Jukka Pätsi; Moshe Finel; Ilmo E Hassinen
A pair of membrane-embedded acidic residues in the NuoK subunit of Escherichia coli NDH-1, a counterpart of the ND4L subunit of the mitochondrial complex I, are required for high ubiquinone reductase activity.
Biochemistry 2004;43(3):773-81.
2004: Marko Kervinen; Jukka Pätsi; Moshe Finel; Ilmo E Hassinen
Lucigenin and coelenterazine as superoxide probes in mitochondrial and bacterial membranes.
Analytical biochemistry 2004;324(1):45-51.
2003: Tiia Kuuranne; Mika Kurkela; Mario Thevis; Wilhelm Schänzer; Moshe Finel; Risto Kostiainen
Glucuronidation of anabolic androgenic steroids by recombinant human UDP-glucuronosyltransferases.
Drug metabolism and disposition: the biological fate of chemicals 2003;31(9):1117-24.
2003: Mika Kurkela; J Arturo García-Horsman; Leena Luukkanen; Saila Mörsky; Jyrki Taskinen; Marc Baumann; Risto Kostiainen; Jouni Hirvonen; Moshe Finel
Expression and characterization of recombinant human UDP-glucuronosyltransferases (UGTs). UGT1A9 is more resistant to detergent inhibition than other UGTs and was purified as an active dimeric enzyme.
The Journal of biological chemistry 2003;278(6):3536-44.
2002: Pamela David; Marc Baumann; Mårten Wikström; Moshe Finel
Interaction of purified NDH-1 from Escherichia coli with ubiquinone analogues.
Biochimica et biophysica acta 2002;1553(3):268-78.
2000: Sari Kurki; V Zickermann; Marko Kervinen; Ilmo E Hassinen; Moshe Finel
Mutagenesis of three conserved Glu residues in a bacterial homologue of the ND1 subunit of complex I affects ubiquinone reduction kinetics but not inhibition by dicyclohexylcarbodiimide.
Biochemistry 2000;39(44):13496-502.
2000: V Zickermann; Sari Kurki; Marko Kervinen; Ilmo E Hassinen; Moshe Finel
The NADH oxidation domain of complex I: do bacterial and mitochondrial enzymes catalyze ferricyanide reduction similarly?
Biochimica et biophysica acta 2000;1459(1):61-8.
2000: K Björklöf; V Zickermann; Moshe Finel
Purification of the 45 kDa, membrane bound NADH dehydrogenase of Escherichia coli (NDH-2) and analysis of its interaction with ubiquinone analogues.
FEBS letters 2000;467(1):105-10.
1999: R Sousa; Blanca Barquera; Margarida Duarte; Moshe Finel; Arnaldo Videira
Characterisation of the last Fe-S cluster-binding subunit of Neurospora crassa complex I.
Biochimica et biophysica acta 1999;1411(1):142-6.
1998: Moshe Finel
Does NADH play a central role in energy metabolism in Helicobacter pylori?
Trends in biochemical sciences 1998;23(11):412-3.
1998: V Zickermann; B Barquera; Mårten Wikström; Moshe Finel
Analysis of the pathogenic human mitochondrial mutation ND1/3460, and mutations of strictly conserved residues in its vicinity, using the bacterium Paracoccus denitrificans.
Biochemistry 1998;37(34):11792-6.
1998: Moshe Finel
Organization and evolution of structural elements within complex I.
Biochimica et biophysica acta 1998;1364(2):112-21.
1997: Moshe Finel; Tuomas Haltia
[The Nobel prize in chemistry for researchers of Na+, K+ ATPase and ATP synthase].
Duodecim; lääketieteellinen aikakauskirja 1997;113(24):2503-7.
1996: Moshe Finel
Genetic inactivation of the H(+)-translocating NADH:ubiquinone oxidoreductase of Paracoccus denitrificans is facilitated by insertion of the ndh gene from Escherichia coli.
FEBS letters 1996;393(1):81-5.
1996: Margarida Duarte; Moshe Finel; Arnaldo Videira
Primary structure of a ferredoxin-like iron-sulfur subunit of complex I from Neurospora crassa.
Biochimica et biophysica acta 1996;1275(3):151-3.
1996: A Majander; Moshe Finel; Marja-Liisa Savontaus; Eeva Nikoskelainen; Mårten Wikström
Catalytic activity of complex I in cell lines that possess replacement mutations in the ND genes in Leber's hereditary optic neuropathy.
European journal of biochemistry / FEBS 1996;239(1):201-7.
1994: Moshe Finel; A S Majander; Jaana Tyynelä; A M De Jong; Simon P J Albracht; Mårten Wikström
Isolation and characterisation of subcomplexes of the mitochondrial NADH:ubiquinone oxidoreductase (complex I).
European journal of biochemistry / FEBS 1994;226(1):237-42.
1994: Mårten Wikström; A Bogachev; Moshe Finel; JE Morgan; Anne Puustinen; M Raitio; Marina L Verkhovskaya; Michael I Verkhovsky
Mechanism of proton translocation by the respiratory oxidases. The histidine cycle.
Biochimica et biophysica acta 1994;1187(2):106-11.
1994: A Majander; Moshe Finel; Mårten Wikström
Diphenyleneiodonium inhibits reduction of iron-sulfur clusters in the mitochondrial NADH-ubiquinone oxidoreductase (Complex I).
The Journal of biological chemistry 1994;269(33):21037-42.
1994: Moshe Finel; A Majander
Studies on the proton-translocating NADH:ubiquinone oxidoreductases of mitochondria and Escherichia coli using the inhibitor 1,10-phenanthroline.
FEBS letters 1994;339(1-2):142-6.
1993: R Lutter; Matti Saraste; H S van Walraven; Michael J Runswick; Moshe Finel; J F Deatherage; John E Walker
F1F0-ATP synthase from bovine heart mitochondria: development of the purification of a monodisperse oligomycin-sensitive ATPase.
The Biochemical journal 1993;295 ( Pt 3)():799-806.
1993: Moshe Finel
The proton-translocating NADH: ubiquinone oxidoreductase: a discussion of selected topics.
Journal of bioenergetics and biomembranes 1993;25(4):357-66.
1992: Moshe Finel; J M Skehel; Simon P J Albracht; I M Fearnley; John E Walker
Resolution of NADH:ubiquinone oxidoreductase from bovine heart mitochondria into two subcomplexes, one of which contains the redox centers of the enzyme.
Biochemistry 1992;31(46):11425-34.
1992: John E Walker; J M Arizmendi; A Dupuis; I M Fearnley; Moshe Finel; S M Medd; S J Pilkington; Michael J Runswick; J M Skehel
Sequences of 20 subunits of NADH:ubiquinone oxidoreductase from bovine heart mitochondria. Application of a novel strategy for sequencing proteins using the polymerase chain reaction.
Journal of molecular biology 1992;226(4):1051-72.
1991: I M Fearnley; Moshe Finel; J M Skehel; John E Walker
NADH:ubiquinone oxidoreductase from bovine heart mitochondria. cDNA sequences of the import precursors of the nuclear-encoded 39 kDa and 42 kDa subunits.
The Biochemical journal 1991;278 ( Pt 3)():821-9.
1991: Anne Puustinen; Moshe Finel; Tuomas Haltia; Robert B Gennis; Mårten Wikström
Properties of the two terminal oxidases of Escherichia coli.
Biochemistry 1991;30(16):3936-42.
1989: Tuomas Haltia; Moshe Finel; N Harms; T Nakari; M Raitio; Mårten Wikström; Matti Saraste
Deletion of the gene for subunit III leads to defective assembly of bacterial cytochrome oxidase.
The EMBO journal 1989;8(12):3571-9.
1989: Anne Puustinen; Moshe Finel; M Virkki; Mårten Wikström
Cytochrome o (bo) is a proton pump in Paracoccus denitrificans and Escherichia coli.
FEBS letters 1989;249(2):163-7.
1988: Moshe Finel; Mårten Wikström
Monomerization of cytochrome oxidase may be essential for the removal of subunit III.
European journal of biochemistry / FEBS 1988;176(1):125-9.
1988: Moshe Finel
Proteolysis of Paracoccus denitrificans cytochrome oxidase by trypsin and chymotrypsin.
FEBS letters 1988;236(2):415-9.
1988: Tuomas Haltia; Anne Puustinen; Moshe Finel
The Paracoccus denitrificans cytochrome aa3 has a third subunit.
European journal of biochemistry / FEBS 1988;172(3):543-6.
1987: Moshe Finel
Studies on the oligomeric state of isolated cytochrome oxidase using cross-linking reagents.
Biochimica et biophysica acta 1987;894(2):174-9.