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Alison Finnegan

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Rachel Rodeghero; Yanxia Cao; Tibor T Glant; Yoichiro Iwakua; Susan A Olalekan; Alison Finnegan
Location of CD4+ T Cell Priming Regulates the Differentiation of Th1 and Th17 Cells and Their Contribution to Arthritis.
Alison Finnegan; Susan Ashaye; Keith M Hamel
B effector cells in rheumatoid arthritis and experimental arthritis.
Anjali Nair; Greg T Spear; Nikhil Verma; Charles Bush-Joseph; Susan Chubinskaya; Mary K Crow; Alison Finnegan; Tibor T Glant; Veero Kanda; Anne-Marie Malfait; Katalin Mikecz; Carla R Scanzello
Synovial fluid from patients with early osteoarthritis modulates fibroblast-like synoviocyte responses to toll-like receptor 4 and toll-like receptor 2 ligands via soluble CD14.

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All Publications

2013: Rachel Rodeghero; Yanxia Cao; Tibor T Glant; Yoichiro Iwakua; Susan A Olalekan; Alison Finnegan
Location of CD4+ T Cell Priming Regulates the Differentiation of Th1 and Th17 Cells and Their Contribution to Arthritis.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(11):5423-35.
2012: Alison Finnegan; Susan Ashaye; Keith M Hamel
B effector cells in rheumatoid arthritis and experimental arthritis.
Autoimmunity 2012;45(5):353-63.
2012: Anjali Nair; Greg T Spear; Nikhil Verma; Charles Bush-Joseph; Susan Chubinskaya; Mary K Crow; Alison Finnegan; Tibor T Glant; Veero Kanda; Anne-Marie Malfait; Katalin Mikecz; Carla R Scanzello
Synovial fluid from patients with early osteoarthritis modulates fibroblast-like synoviocyte responses to toll-like receptor 4 and toll-like receptor 2 ligands via soluble CD14.
Arthritis and rheumatism 2012;64(7):2268-77.
2011: Keith M Hamel; Marilyn R Kehry; Yumei Wang; Tibor T Glant; Susan Ashaye; Yanxia Cao; Robert Dunn; Alison Finnegan
B cell depletion enhances T regulatory cell activity essential in the suppression of arthritis.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(9):4900-6.
2011: Tibor T Glant; Marianna Radacs; Gyorgy Nagyeri; Katalin Olasz; Anna Laszlo; Ferenc Boldizsar; Akos Hegyi; Alison Finnegan; Katalin Mikecz
Proteoglycan-induced arthritis and recombinant human proteoglycan aggrecan G1 domain-induced arthritis in BALB/c mice resembling two subtypes of rheumatoid arthritis.
Arthritis and rheumatism 2011;63(5):1312-21.
2010: Keith M Hamel; Yanxia Cao; Yumei Wang; Rachel Rodeghero; Tamas Kobezda; Lieping Chen; Alison Finnegan
B7-H1 expression on non-B and non-T cells promotes distinct effects on T- and B-cell responses in autoimmune arthritis.
European journal of immunology 2010;40(11):3117-27.
2010: Paul D Doodes; Yanxia Cao; Keith M Hamel; Yumei Wang; Rachel L Rodeghero; Katalin Mikecz; Tibor T Glant; Yoichiro Iwakura; Alison Finnegan
IFN-gamma regulates the requirement for IL-17 in proteoglycan-induced arthritis.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(3):1552-9.
2009: M Reza Zariffard; Mohammed Saifuddin; Alison Finnegan; Gregory T Spear
HSV type 2 infection increases HIV DNA detection in vaginal tissue of mice expressing human CD4 and CCR5.
AIDS research and human retroviruses 2009;25(11):1157-64.
2009: Paul D Doodes; Yanxia Cao; Keith M Hamel; Yumei Wang; Rachel L Rodeghero; Tamas Kobezda; Alison Finnegan
CCR5 is involved in resolution of inflammation in proteoglycan-induced arthritis.
Arthritis and rheumatism 2009;60(10):2945-53.
2009: Shannon K O'Neill; Margaret L Veselits; Miao Zhang; Christine Labno; Yanxia Cao; Alison Finnegan; Melissa Uccellini; Maria-Luisa Alegre; John C Cambier; Marcus R Clark
Endocytic sequestration of the B cell antigen receptor and toll-like receptor 9 in anergic cells.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(15):6262-7.
2009: Balint Farkas; Ferenc Boldizsar; Oktavia Tarjanyi; Anna Laszlo; Simon M Lin; Gabor Hutas; Beata Tryniszewska; Aaron Mangold; Gyorgy Nagyeri; Holly L Rosenzweig; Alison Finnegan; Katalin Mikecz; Tibor T Glant
BALB/c mice genetically susceptible to proteoglycan-induced arthritis and spondylitis show colony-dependent differences in disease penetrance.
Arthritis research & therapy 2009;11(1):R21.
2008: Gábor Hutás; Eva Bajnok; István Gál; Alison Finnegan; Tibor T Glant; Katalin Mikecz
CD44-specific antibody treatment and CD44 deficiency exert distinct effects on leukocyte recruitment in experimental arthritis.
Blood 2008;112(13):4999-5006.
2008: Alison Finnegan; Paul D Doodes
Pathways for interleukin-1-driven arthritis.
Arthritis and rheumatism 2008;58(11):3283-5.
2008: Miklos Tunyogi-Csapo; Katalin Kis-Toth; Marianna Radacs; Balint Farkas; Joshua J Jacobs; Alison Finnegan; Katalin Mikecz; Tibor T Glant
Cytokine-controlled RANKL and osteoprotegerin expression by human and mouse synovial fibroblasts: fibroblast-mediated pathologic bone resorption.
Arthritis and rheumatism 2008;58(8):2397-408.
2008: Keith Hamel; Paul Doodes; Yanxia Cao; Yumei Wang; Jeffrey A Martinson; Robert Dunn; Marilyn R Kehry; Balint Farkas; Alison Finnegan
Suppression of proteoglycan-induced arthritis by anti-CD20 B Cell depletion therapy is mediated by reduction in autoantibodies and CD4+ T cell reactivity.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(7):4994-5003.
2008: Yanxia Cao; Paul D Doodes; Tibor T Glant; Alison Finnegan
IL-27 induces a Th1 immune response and susceptibility to experimental arthritis.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(2):922-30.
2008: Nadim J Hallab; Marco Caicedo; Alison Finnegan; Joshua J Jacobs
Th1 type lymphocyte reactivity to metals in patients with total hip arthroplasty.
Journal of orthopaedic surgery and research 2008;3():6.
2007: Shannon K O'Neill; Yanxia Cao; Keith M Hamel; Paul D Doodes; Gabor Hutas; Alison Finnegan
Expression of CD80/86 on B cells is essential for autoreactive T cell activation and the development of arthritis.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(8):5109-16.
2007: Yanxia Cao; Frank Brombacher; Miklos Tunyogi-Csapo; Tibor T Glant; Alison Finnegan
Interleukin-4 regulates proteoglycan-induced arthritis by specifically suppressing the innate immune response.
Arthritis and rheumatism 2007;56(3):861-70.
2007: Deri Morgan; Vladimir V Cherny; Alison Finnegan; James Bollinger; Michael H Gelb; Thomas DeCoursey
Sustained activation of proton channels and NADPH oxidase in human eosinophils and murine granulocytes requires PKC but not cPLA2 alpha activity.
The Journal of physiology 2007;579(Pt 2):327-44.
2007: Shannon K O'Neill; Tibor T Glant; Alison Finnegan
The role of B cells in animal models of rheumatoid arthritis.
Frontiers in bioscience : a journal and virtual library 2007;12():1722-36.
2006: Vyacheslav Adarichev; Csaba Vermes; Anita Hanyecz; Katalin Kis-Toth; Miklos Tunyogi-Csapo; Alison Finnegan; Katalin Mikecz; Tibor T Glant
Antigen-induced differential gene expression in lymphocytes and gene expression profile in synovium prior to the onset of arthritis.
Autoimmunity 2006;39(8):663-73.
2006: Bara Sarraj; Katalin Kis-Toth; Tibor T Glant; Alison Finnegan; Katalin Mikecz
Expression of CD44 and L-selectin in the innate immune system is required for severe joint inflammation in the proteoglycan-induced murine model of rheumatoid arthritis.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(3):1932-40.
2005: Edit Buzás; Anikó Végvári; Yanal Murad; Alison Finnegan; Katalin Mikecz; Tibor T Glant
T-cell recognition of differentially tolerated epitopes of cartilage proteoglycan aggrecan in arthritis.
Cellular immunology 2005;235(2):98-108.
2005: Charles D Kaplan; Yancia Cao; Sjef Verbeek; Miklos Tunyogi-Csapo; Alison Finnegan
Development of proteoglycan-induced arthritis is critically dependent on Fcgamma receptor type III expression.
Arthritis and rheumatism 2005;52(5):1612-9.
2005: Shannon K O'Neill; Mark J Shlomchik; Tibor T Glant; Yanxia Cao; Paul D Doodes; Alison Finnegan
Antigen-specific B cells are required as APCs and autoantibody-producing cells for induction of severe autoimmune arthritis.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(6):3781-8.
2004: Dongdong Li; István Gál; Csaba Vermes; Maria-Luisa Alegre; Anita S Chong; Lieping Chen; Qing Shao; Vyacheslav Adarichev; Xuemei Xu; Tamas Koreny; Katalin Mikecz; Alison Finnegan; Tibor T Glant; Jian Zhang
Cutting edge: Cbl-b: one of the key molecules tuning CD28- and CTLA-4-mediated T cell costimulation.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(12):7135-9.
2004: Tibor T Glant; Vyacheslav Adarichev; Andrew B Nesterovitch; S Szanto; J P Oswald; Joshua J Jacobs; Gábor Firneisz; Jian Zhang; Alison Finnegan; Katalin Mikecz
Disease-associated qualitative and quantitative trait loci in proteoglycan-induced arthritis and collagen-induced arthritis.
The American journal of the medical sciences 2004;327(4):188-95.
2003: Vyacheslav Adarichev; Andrew B Nesterovitch; Tamás Bárdos; Darci Biesczat; Raman Chandrasekaran; Csaba Vermes; Katalin Mikecz; Alison Finnegan; Tibor T Glant
Sex effect on clinical and immunologic quantitative trait loci in a murine model of rheumatoid arthritis.
Arthritis and rheumatism 2003;48(6):1708-20.
2003: Charles Kaplan; Alison Finnegan
Osteoclasts, pro-inflammatory cytokines, RANK-L and bone remodeling in rheumatoid arthritis.
Frontiers in bioscience : a journal and virtual library 2003;8():d1018-29.
2003: Jian Zhang; Tamás Bárdos; Qing Shao; Jurg Tschopp; Katalin Mikecz; Tibor T Glant; Alison Finnegan
IL-4 potentiates activated T cell apoptosis via an IL-2-dependent mechanism.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(7):3495-503.
2003: Vyacheslav Adarichev; Juan C Valdez; Tamás Bárdos; Alison Finnegan; Katalin Mikecz; Tibor T Glant
Combined autoimmune models of arthritis reveal shared and independent qualitative (binary) and quantitative trait loci.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(5):2283-92.
2003: Tibor T Glant; Alison Finnegan; Katalin Mikecz
Proteoglycan-induced arthritis: immune regulation, cellular mechanisms, and genetics.
Critical reviews in immunology 2003;23(3):199-250.
2003: Tamas Bardos; Matyas Czipri; Csaba Vermes; Alison Finnegan; Katalin Mikecz; Jian Zhang
CD4+CD25+ immunoregulatory T cells may not be involved in controlling autoimmune arthritis.
Arthritis research & therapy 2003;5(2):R106-13.
2003: Alison Finnegan; Charles D Kaplan; Yanxia Cao; Hermann Eibel; Tibor T Glant; Jian Zhang
Collagen-induced arthritis is exacerbated in IL-10-deficient mice.
Arthritis research & therapy 2003;5(1):R18-24.
2002: Charles D Kaplan; Shannon K O'Neill; Tamas Koreny; Matyas Czipri; Alison Finnegan
Development of inflammation in proteoglycan-induced arthritis is dependent on Fc gamma R regulation of the cytokine/chemokine environment.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(10):5851-9.
2002: Alison Finnegan; Michael J Grusby; Charles D Kaplan; Shannon K O'Neill; Hermann Eibel; Tamas Koreny; Matyas Czipri; Katalin Mikecz; Jian Zhang
IL-4 and IL-12 regulate proteoglycan-induced arthritis through Stat-dependent mechanisms.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(6):3345-52.
2002: Jian Zhang; Tamás Bárdos; Dongdong Li; István Gál; Csaba Vermes; Jianye Xu; Katalin Mikecz; Alison Finnegan; Stan Lipkowitz; Tibor T Glant
Cutting edge: regulation of T cell activation threshold by CD28 costimulation through targeting Cbl-b for ubiquitination.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(5):2236-40.
2002: Nadav Dujovny; Anncy Varghese; Jikun Shen; Dengping Yin; Shaoquan Ji; LianLi Ma; Alison Finnegan; Anita S Chong
Acute xenograft rejection mediated by antibodies produced independently of TH1/TH2 cytokine profiles.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2002;2(6):526-34.
2002: Tamás Bárdos; Katalin Mikecz; Alison Finnegan; Jian Zhang; Tibor T Glant
T and B cell recovery in arthritis adoptively transferred to SCID mice: antigen-specific activation is required for restoration of autopathogenic CD4+ Th1 cells in a syngeneic system.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(12):6013-21.
2002: Charles Kaplan; Juan C Valdez; Raman Chandrasekaran; Hermann Eibel; Katalin Mikecz; Tibor T Glant; Alison Finnegan
Th1 and Th2 cytokines regulate proteoglycan-specific autoantibody isotypes and arthritis.
Arthritis research 2002;4(1):54-8.
2001: Jian Zhang; Tamás Bárdos; Katalin Mikecz; Alison Finnegan; Tibor T Glant
Impaired Fas signaling pathway is involved in defective T cell apoptosis in autoimmune murine arthritis.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(8):4981-6.
2001: Tibor T Glant; Tamás Bárdos; Csaba Vermes; Raman Chandrasekaran; J C Valdéz; Jeffrey M Otto; D Gerard; S Velins; G Lovász; J Zhang; Katalin Mikecz; Alison Finnegan
Variations in susceptibility to proteoglycan-induced arthritis and spondylitis among C3H substrains of mice: evidence of genetically acquired resistance to autoimmune disease.
Arthritis and rheumatism 2001;44(3):682-92.
2000: Jeffrey M Otto; R Chandrasekeran; Csaba Vermes; Katalin Mikecz; Alison Finnegan; S E Rickert; J T Enders; Tibor T Glant
A genome scan using a novel genetic cross identifies new susceptibility loci and traits in a mouse model of rheumatoid arthritis.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(9):5278-86.
2000: Jian Zhang; Katalin Mikecz; Alison Finnegan; Tibor T Glant
Spontaneous thymocyte apoptosis is regulated by a mitochondrion-mediated signaling pathway.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(6):2970-4.
2000: Krisztina Holló; Tibor T Glant; M Garzó; Alison Finnegan; Katalin Mikecz; Edit Buzás
Complex pattern of Th1 and Th2 activation with a preferential increase of autoreactive Th1 cells in BALB/c mice with proteoglycan (aggrecan)-induced arthritis.
Clinical and experimental immunology 2000;120(1):167-73.
1999: Kenneth A Roebuck; Alison Finnegan
Regulation of intercellular adhesion molecule-1 (CD54) gene expression.
Journal of leukocyte biology 1999;66(6):876-88.
1999: Alison Finnegan; Katalin Mikecz; P Tao; Tibor T Glant
Proteoglycan (aggrecan)-induced arthritis in BALB/c mice is a Th1-type disease regulated by Th2 cytokines.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(10):5383-90.
1998: MF Rabbi; Alison Finnegan; Lena Al-Harthi; S Song; Kenneth A Roebuck
Interleukin-10 enhances tumor necrosis factor-alpha activation of HIV-1 transcription in latently infected T cells.
Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association 1998;19(4):321-31.
1998: Tibor T Glant; Edit Buzás; Alison Finnegan; G Negroiu; Gabriella Cs-Szabó; Katalin Mikecz
Critical roles of glycosaminoglycan side chains of cartilage proteoglycan (aggrecan) in antigen recognition and presentation.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(8):3812-9.
1998: K Siemasko; Anita S Chong; Hans-Martin Jäck; H Gong; J W Williams; Alison Finnegan
Inhibition of JAK3 and STAT6 tyrosine phosphorylation by the immunosuppressive drug leflunomide leads to a block in IgG1 production.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(4):1581-8.
1998: X Xu; James W Williams; JiKun Shen; H Gong; Deng-Ping Yin; L Blinder; R T Elder; Howard Sankary; Alison Finnegan; Anita S Chong
In vitro and in vivo mechanisms of action of the antiproliferative and immunosuppressive agent, brequinar sodium.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(2):846-53.
1997: X Xu; L Blinder; JiKun Shen; H Gong; Alison Finnegan; James W Williams; Anita S Chong
In vivo mechanism by which leflunomide controls lymphoproliferative and autoimmune disease in MRL/MpJ-lpr/lpr mice.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(1):167-74.
1997: R T Elder; X Xu; James W Williams; H Gong; Alison Finnegan; Anita S Chong
The immunosuppressive metabolite of leflunomide, A77 1726, affects murine T cells through two biochemical mechanisms.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(1):22-7.
1997: S Song; H Ling-Hu; Kenneth A Roebuck; MF Rabbi; R P Donnelly; Alison Finnegan
Interleukin-10 inhibits interferon-gamma-induced intercellular adhesion molecule-1 gene transcription in human monocytes.
Blood 1997;89(12):4461-9.
1996: K M Nikcevich; D Kopielski; Alison Finnegan
The immunodominant region of Staphylococcal nuclease is represented by multiple peptide sequences.
Cellular immunology 1996;172(2):254-61.
1996: X Xu; James W Williams; H Gong; Alison Finnegan; Anita S Chong
Two activities of the immunosuppressive metabolite of leflunomide, A77 1726. Inhibition of pyrimidine nucleotide synthesis and protein tyrosine phosphorylation.
Biochemical pharmacology 1996;52(4):527-34.
1996: K F Siemasko; Anita S Chong; James W Williams; E G Bremer; Alison Finnegan
Regulation of B cell function by the immunosuppressive agent leflunomide.
Transplantation 1996;61(4):635-42.
1996: Anita S Chong; K Rezai; Howard M. Gebel; Alison Finnegan; P Foster; X Xu; James W Williams
Effects of leflunomide and other immunosuppressive agents on T cell proliferation in vitro.
Transplantation 1996;61(1):140-5.
1996: Alison Finnegan; Kenneth A Roebuck; B E Nakai; D S Gu; MF Rabbi; S Song; A L Landay
IL-10 cooperates with TNF-alpha to activate HIV-1 from latently and acutely infected cells of monocyte/macrophage lineage.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(2):841-51.
1995: X Xu; James W Williams; E G Bremer; Alison Finnegan; Anita S Chong
Inhibition of protein tyrosine phosphorylation in T cells by a novel immunosuppressive agent, leflunomide.
The Journal of biological chemistry 1995;270(21):12398-403.
1995: R F Dennis; K F Siemasko; Q Tang; RL Hendricks; Alison Finnegan
Involvement of LFA-1 and ICAM-1 in the herpetic disease resulting from HSV-1 corneal infection.
Current eye research 1995;14(1):55-62.
1994: K M Nikcevich; D Kopielski; Alison Finnegan
Interference with the binding of a naturally processed peptide to class II alters the immunodominance of T cell epitopes in vivo.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(3):1015-26.
1993: T Mattar; K Kochhar; R Bartlett; E G Bremer; Alison Finnegan
Inhibition of the epidermal growth factor receptor tyrosine kinase activity by leflunomide.
FEBS letters 1993;334(2):161-4.
1993: Anita S Chong; Alison Finnegan; X Jiang; Howard M. Gebel; Howard Sankary; P Foster; James W Williams
Leflunomide, a novel immunosuppressive agent. The mechanism of inhibition of T cell proliferation.
Transplantation 1993;55(6):1361-6.
1993: Anita S Chong; Howard M. Gebel; Alison Finnegan; E E Petraitis; X L Jiang; Howard Sankary; P Foster; James W Williams
Leflunomide, a novel immunomodulatory agent: in vitro analyses of the mechanism of immunosuppression.
Transplantation proceedings 1993;25(1 Pt 1):747-9.
1992: Alison Finnegan; J Regan; K B Seamon; C Lindholm
Identification of single amino acid substitutions in the staphylococcal nuclease protein that enhance and diminish T cell clone recognition of naturally processed peptides.
International immunology 1992;4(12):1399-406.
1992: RL Hendricks; T M Tumpey; Alison Finnegan
IFN-gamma and IL-2 are protective in the skin but pathologic in the corneas of HSV-1-infected mice.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(9):3023-8.
1992: M F Naujokas; E Schmitt; Alison Finnegan
Regulation of freshly isolated, IL-4-producing T cells: IFN-gamma-sensitive and -resistant cells.
Lymphokine and cytokine research 1992;11(3):183-91.